Digital Commons Network^™

Mir147 Promotes Mucosal Integrity And Healing In Intestinal Inflammation, Agnieszka K Czopik, Arash Dabiri, Chia-Hao Tung, Victoria Vaughn, Xiangsheng Huang, Jinlian Wang, Hui Li, Nicolas F Moreno, Natalia V Piwko, Katherine Figarella, Hongfang Liu, Zhongming Zhao, Xiaoyi Yuan, Holger K Eltzschig

Faculty, Staff and Student Publications

The intestinal mucosal epithelium forms a barrier between luminal contents and the body. MicroRNAs (miRNAs) regulate mucosal homeostasis by controlling inflammatory responses and structural integrity. Here, we discovered a protective role for miR147 in intestinal inflammation using a miR147tdTomato reporter mouse. miR147 was enriched in the intestines, with the highest expression in the colonic epithelial cells at the luminal surface, with prominent expression in differentiated enterocytes. Mice with general or intestinal epithelial deletion of miR147 showed increased intestinal inflammation and diminished mucosal healing during colitis. RNA sequencing of miR147-deficient cells showed dysregulated immune signaling, with upregulated proinflammatory cytokine pathways and …

Myocardial Protection By Acidic Amino Acids And Natural Dipeptides: Potential For An Underused Resource, N. King

School of Biomedical Sciences

Stopping then restarting the blood flow to the heart can cause ischaemia reperfusion (IR) injury. This can happen during revascularisation following a myocardial infarction and during on pump cardiac surgery using cardioplegic arrest. Despite extensive studies to identify cardioprotective interventions, the myocardium continues to sustain significant injury. Therefore, there is a need to identify agents that can be used during IR. This review focuses on the potential cardioprotective role for acidic amino acids and natural dipeptides using evidence from experimental studies and clinical trials with particular emphasis on their membrane transport. Acidic amino acids are present at high concentration in …

Review - Shahzia Sikander: Collective Behavior, Annie Dell'aria

Art Inquiries

Shahzia Sikander’s work spans traditions from multiple continents, eras, and media. Trained in the traditional miniature painting of South Asia and Persia, yet creating monumental pieces that command space both inside and outside the gallery, this artistic polymath maintains a signature style rooted in sumptuous detail and motifs that drip with layers of meaning. In Collective Behavior, a multi-part, career-spanning traveling museum exhibition of works made over the past 35 years, Sikander’s full array of talent and artistic evolution is on display.

Art Inquiries Volume Xx No 1 2025 - Full Issue, Kris K. Belden-Adams

Art Inquiries

No abstract provided.

Defining Endotypes Of Bronchopulmonary Dysplasia In Preterm Infants To Improve Precision-Based Therapies., Megha Sharma, Gangaram Akangire, Noah H. Hillman, Winston M. Manimtim, Mark Ivan Attard, Venkatesh Sampath

Manuscripts, Articles, Book Chapters and Other Papers

Bronchopulmonary dysplasia (BPD) remains a debilitating disease in premature infants. The chronic pathogenesis of BPD with complex prenatal and postnatal programming challenges attempts at precisely defining or treating disease. While existing BPD definitions categorize disease severity, a lack of consideration of disease heterogeneity and endotypes has contributed to the failure of clinical trials to improve BPD outcomes. Recent studies have used advanced lung imaging techniques, echocardiography, and lung function tests to identify airway, parenchymal, and vascular BPD endotypes. These endotypes carry different prognoses and require endotype-specific treatment strategies to optimize infant outcomes. In this Review, we focus on the pathogenic …

2025-10-22 Seattleites Say “No Kings” In Nationwide Rally, Max Schoettmer

The Spectator Online

No abstract provided.

Epidemiology Of Lower Extremity Amputations In The United States: An Analysis Of The Global Burden Of Disease Database From 1990 To 2019, Peter B. Spencer, Cameron J. Sabet, Gabrielle Dykhouse, Taylor Manes, Phillip C. Mckegg, Ambrose Loc T. Ngo, Ayah Ibrahim, Jack W. Weick

Student Publications

Background: Lower extremity amputations (LEAs) are medically, psychologically, and functionally devastating. The objective of our study was to evaluate region- and sex-specific differences of unilateral and bilateral LEAs across the United States (US) from 1990 to 2019.

Methods: The Global Burden of Disease database was used to analyze years lived with disability (YLDs), prevalence, and incidence rates per 100,000 people for LEAs in the US from 1990 to 2019. Data were stratified into four US Census Bureau-defined regions: Northeast, Midwest, South, and West. Differences between regions and sexes were assessed, with statistical significance defined as p < 0.05.

Results: From 1990 to …

On The Ecological Impact Of Prehistoric Hunter-Gatherers In Europe: Early Holocene (Mesolithic) And Last Interglacial (Neanderthal) Foragers Compared, Anastasia Nikulina, Anhelina Zapolska, Maria Antonia Serge, Didier M. Roche, Florence Mazier, Marco Davoli, Elena A. Pearce, Jens Christian Svenning, Dave Van Wees, Ralph Fyfe, Katharine Macdonald, Wil Roebroeks, Fulco Scherjon

School of Geography, Earth and Environmental Sciences

Recent studies have highlighted evidence of human impact on landscapes dating back to the Late Pleistocene–long before the advent of agriculture. Quantifying the extent of vegetation transformations by hunter-gatherers remains a major research challenge. We address this challenge by comparing climate-based potential natural vegetation cover with pollen-based vegetation reconstructions for the Last Interglacial and the Early Holocene. Differences between these datasets suggest that climate alone cannot fully explain the pollen-based vegetation patterns in Europe during these periods. To explore this issue, we used an upgraded version of the HUMan impact on LANDscapes (HUMLAND) agent-based model (ABM), combined with a genetic …

Liability In The Pipeline: The Expanding Scope Of Pfas Litigation And Regulation, Rebecca Huckabay

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Walking On Sunshine: A Survey Of Oklahoma Concurrent Land Use Law And How Accommodation Can Fill In Gaps Revealed By Emerging Solar Energy, Nick Halbroeder

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

The Clash Between Oklahoma’S Oil Industry And Overriding Royalty Interests: Why Legislative Action Is Needed, Bryce Cormack

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Not All That Glitters Is Black Gold: Using Stranded Gas To Mine Cryptocurrencies And The Public Regulation Of Waste, Emily Burns

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Renoprotective Potential Of Ciprofloxacin, Prednisolone, And Infliximab In Acetic Acid-Induced Ulcerative Colitis Rats, O. A. Oyesola, O. E. Olayemi, B. I. Kukoyi

AUIQ Complementary Biological System

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with systemic manifestations, including renal impairment mediated by oxidative stress, inflammation, and electrolyte imbalance. This study investigated the renoprotective potential of ciprofloxacin, prednisolone, and infliximab in rats with acetic acid–induced UC. Fifty male Sprague–Dawley rats (180–200 g) were divided into five groups (n = 10): control, UC control, UC + ciprofloxacin (50 mg/kg, p.o.), UC + prednisolone (4 mg/kg, p.o.), and UC + infliximab (5 mg/kg, i.p.). UC was induced by rectal instillation of 4% acetic acid, and treatments were administered for 42 days. Serum urea, creatinine, electrolytes, and malondialdehyde (MDA) …

Sharer Intention Analysis For Content Type Detection, Jieyu Tan, Karlheinz Wurm, Soya Li, Wallice Wang

Defensive Publications Series

In online conference scenarios, shared content detection is widely used to determine whether content being shared is text content or video content. Determining the type of shared content can impact whether the video mode for the online conference favors higher resolution (for text content) or smoother motion (for video content). A system is proposed herein that leverages predictive hints from user actions (e.g., opening applications or files) and contextual audio cues to anticipate upcoming shared content types (e.g., video or text). By combining these hints with real-time content analysis, the system preemptively switches to the appropriate video mode for an …

Purple Tomatoes Boost Nutrition Crop Value And Create New Opportunities For United States (U.S) Agriculture, Tariq Alam

Agronomic Crops

The agricultural landscape in the United States is continually evolving, with growers and the tomato industry seeking innovative ways to meet consumer demands while enhancing profitability. The introduction of both bioengineered and classically bred anthocyanins-enriched purple tomatoes presents a unique opportunity for U.S. growers to cultivate a high-value crop that appeals to niche markets and commands premium pricing. Bioengineered purple tomatoes achieve high anthocyanin levels through the introduction of snapdragon transcription factors, while classically bred 'Indigo Rose' purple tomatoes are developed via classical breeding methods, providing an alternative for consumers who prefer traditionally bred products. Specifically, the purple tomato holds …

Dairy And Food Science Student Newsletter, October 21, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

Marigold-Silver Nanoparticles (Agnps) Complex: Characterization, Therapeutic Potential, And Future Approaches For Lung Injury Via Antioxidant And Anti-Inflammatory Effects, Navdeep Kaur

USF Tampa Graduate Theses and Dissertations

Chronic respiratory diseases (CRDs) and other lung conditions are a key cause of the problems facing global health, as they greatly increase morbidity, death, and the financial burden. In order to achieve the third Sustainable Development Goal of the United Nations, which is to reduce premature mortality from non-communicable illnesses by one-third by 2030, updated epidemiological statistics are crucial for directing prevention, control, and treatment measures. One of the major reasons of illness and death globally is chronic obstructive pulmonary disease (COPD). Lung damage and the emergence of CRDs, such as asthma, emphysema, COPD, and other respiratory disorders, are largely …

Longitudinal Case Studies: Using Pat Data To Inform Teaching And Learning, Shani Sniedze, Marc Kralj

Assessment and Reporting

The ACER Progressive Achievement approach includes PAT assessments that measure what students know, understand, and can do across the domains of Reading, Spelling, Vocabulary, Grammar and Punctuation, Maths, Science, Inquiry and Problem Solving in STEM Contexts, and Critical Reasoning. The results of PAT assessments are available immediately to schools. This helps schools diagnose student needs and implement teaching and learning strategies in a timely manner. If PAT assessments are used at recommended intervals, schools can also see student learning growth over time. This collection of Progressive Achievement Test (PAT) case studies conducted across 2022–2024, demonstrates how PAT assessments are used …

Kenyon Collegiate - October 21, 2025

Kenyon Collegiate

No abstract provided.

A Global Overview Of Anatomical Science Education And Its Present And Future Role In Biomedical Curricula, Michael Hortsch, Virginia Claudia Carneiro Girão-Carmona, Ana Caroline Rocha De Melo Leite, Ilias P. Nikas, Margaret K. Gatumu, Nii Koney Kwaku Koney, Benjamin Arko-Boham, Doris George Yohannan, Aswathy Maria Oommen, Yan Li, Jian Yang, Alexandra F. Trollope, Amanda J. Meyer, Sonya E. Van Nuland

School of Medicine Faculty Publications

The four main anatomical sciences, gross anatomy, histology, neuroanatomy, and embryology, are fundamental subjects for most health professionals and biomedical students. Usually taught as part of preclinical basic science training, the anatomical sciences provide a structural understanding of human or animal bodies at both macroscopic and microscopic levels. This overview characterizes how the anatomical sciences are currently taught around the globe, highlighting similarities, differences, and recent curricular transformations that were partially in response to the COVID-19 pandemic. Globally, educators of the anatomical sciences navigate similar pressures, including expectations of curricular integration and reduced time for anatomical teaching. Student-centered teaching approaches …

Executive Committee - Agenda, 10/21/2025, Academic Senate

Academic Senate Agendas

No abstract provided.

Naturalizing Motherhood: Neoliberal Femininity And The Re-Traditionalization Of Gender In Turkey, Canan Tanir

Sociology Faculty Publications

The recent trends in the social construction of “good mothering” through “naturalism” have become remarkably definitive in Turkey in the last decade. This study presents data from in-depth interviews with naturalist mothers in Istanbul demonstrating four operative mechanisms in their narratives with regard to their conception of gender. Practices of naturalist motherhood depart from systemic criticism and opposition to the ongoing neoliberal conservatization process in Turkey. However, at the same time, they are congruent with the normalization of a patriarchal gender order in this context. I propose that addressing this controversy is contingent on problematizing the focus on choice and …

Proteomic Analysis Of Central Amygdala Systems Regulated By Mifepristone In The Context Of Alcohol Dependence, Stephanie S. Lee, Laura Monteagudo Romero, John W. Lammons, Jennifer M. Klein, Kimberly N. Edwards, Jessie J. Guidry, Scott Edwards

School of Graduate Studies Faculty Publications

Alcohol use disorder (AUD) is a psychiatric disorder characterized by escalated alcohol use and the emergence of negative affective symptoms. Studies have described a dysregulation of glucocorticoid receptor (GR) signaling in the context of AUD at the levels of the hypothalamic-pituitary-adrenal (HPA) axis and central amygdala (CeA). A functional increase in CeA GR activity occurs during alcohol withdrawal in alcohol-dependent animal models, and the GR antagonist mifepristone reduces alcohol-seeking and drinking behaviors in both rodents and humans. The aims of this study were to determine differential CeA protein expression in alcohol-dependent rats and examine the effects of mifepristone treatment in …

Spartan Daily, October 21, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 25

Sexually Dimorphic Sail Feathers In The Mandarin Duck As A Model For Lifelong Developmental Modulation, Pin-Chi Tang, Hsu-Chen Cheng, Gee-Way Lin, Yung-Chih Lai, Ya-Chen Liang, Ping Wu, Tzu-Chiao Lin, Chen Siang Ng, Isheng Jason Tsai, Ang Li, Wen Hsiung Li, Chih-Feng Chen, Cheng-Ming Chuong, Randall Widelitz

Faculty, Staff and Student Publications

Developmental processes extend beyond embryogenesis to support lifelong tissue adaptations. Avian feather follicles, with their resident stem cells and capacity for cyclic regeneration, provide a dynamic model for postnatal tissue remodeling. Here, we propose the Mandarin duck (Aix galericulata) as an ideal model to study lifelong developmental modulation, focusing on the sexually dimorphic "sail feather"-a secondary flight feather in males that undergoes seasonal transformation into a strikingly asymmetric, ornamented phenotype during the breeding season. We identified asymmetric morphogen expression in regenerating male sail feathers and used transcriptome and H3K27ac ChIP-seq to uncover male and female signaling pathways and regulatory elements. …

Fort Brooke After 200 Years: A Public Heritage Approach, Alex F. Fawbush

USF Tampa Graduate Theses and Dissertations

Fort Brooke, established in 1824 at the mouth of the Hillsborough River, shaped the growth of Tampa and Florida’s west coast for nearly sixty years and served as the nucleus for the forced removal of Indigenous people. Though the Fort itself has long since vanished beneath the modern city, archaeology has preserved its legacy. Excavations since the 1970s have uncovered rich assemblages of ceramics, glass, military equipment, faunal remains, and domestic refuse. These materials reveal daily life at the post, highlighting the interactions of soldiers, Seminoles, African Americans, white settlers, and Cuban fishermen, while also uncovering the deeper prehistoric, referred …

The Impact Of Sglt2 Inhibitors On Pulmonary Artery Pressures And Pulmonary Hemodynamics In Patients With Heart Failure: A Systematic Review, Kritick Bhandari, Maria Qadri, Rochak Dhakal, Sagun Ghimire, Gyanendra Jora, Santosh Basyal, Et. Al.

Michigan Tech Publications

Background: Heart failure is a major global health burden associated with high morbidity and mortality. Elevated pulmonary artery pressures (PAP) are linked to worse outcomes in heart failure patients. Sodium–glucose cotransporter 2 (SGLT2) inhibitors, initially developed for diabetes, have demonstrated cardiovascular benefits, but their specific effects on pulmonary hemodynamics remain unclear.

Methods: This systematic review analyzed randomized controlled trials and observational cohort studies evaluating the effects of SGLT2 inhibitors on mean pulmonary artery pressure (mPAP) and pulmonary artery systolic pressure (PASP) in heart failure patients. A comprehensive search of PubMed, Embase, Cochrane Library, and Scopus databases was conducted until August …

Occurrence Of Delphinids Off Egmont Atoll, Chagos Archipelago: Detection, Characterisation, And Temporal Variability Of Vocalisations, Udayanga Sampath, Clare B Embling, Danielle V Harris, Tom B Letessier, Isha Shyam, Simon N Ingram, M F M Fairoz, Samina Sharmin Rouf, Asha De Vos

School of Biological and Marine Sciences

Passive acoustic monitoring techniques are useful for studying vocally active marine species, particularly in remote and difficult to access areas. In this study, three months of acoustic recordings were collected off Egmont Atoll, Chagos Archipelago in the central Indian Ocean to detect, characterise, and investigate temporal variability of delphinid whistles. A subsample (3.6% of the total dataset) was used to manually annotate whistles and test automated whistle detectors. Higher frequency whistles (6-25 kHz, n = 126) were manually classified into six categories: upsweep (56%), convex (19%), downsweep (13%), concave (5%), sine (4%), and constant frequency (3%). An automated whistle detector …

Apoa1 Binding Protein Promotes Lymphatic Cell Fate And Lymphangiogenesis By Relieving Caveolae-Mediated Inhibition Of Vegfr3 Signaling, Jun-Dae Kim, Surbhi Chaudhary, Weiqing Chen, Jonathan Astin, Philip S Crosier, Pengchun Yu, John P Cooke, Henry J Pownall, Hugo J Bellen, Nhat-Tu Le, Daniel L Kiss, Guangyu Wang, Stanley G Rockson, Hong Chen, Longhou Fang

Faculty, Staff and Students Publications

The lymphatic system maintains tissue fluid balance, and its dysfunction can result in lymphedema. Although cholesterol is essential for cellular function, its role in lymphatic development has remained unknown. Here, we identify APOA1 binding protein (AIBP) as a key regulator that promotes lymphatic endothelial cell fate specification and lymphangiogenesis. Mechanistically, AIBP reduces plasma membrane cholesterol content, thereby enhancing VEGFR3 signaling by disrupting caveolae—small plasma membrane invaginations formed by the scaffolding protein caveolin-1 (CAV-1)—and relieving CAV-1–mediated inhibition. In zebrafish and mice, AIBP loss impairs VEGFR3 signaling and lymphatic development, defects that can be rescued by CAV-1 deletion or by a VEGFR3 …

Sperm And Offspring Production In A Nonobstructive Azoospermia Mouse Model Via Testicular Mrna Delivery Using Lipid Nanoparticles, Daisuke Mashiko, Chihiro Emori, Yuki Hatanaka, Daisuke Motooka, Chen Pan, Yuki Kaneda, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Microsurgical testicular sperm extraction (microTESE) with intracytoplasmic sperm injection (ICSI) represents the current standard treatment for nonobstructive azoospermia (NOA). However, cures remain unavailable for NOA patients lacking retrievable haploid cells. mRNA supplementation could be a potential treatment for genetic defects leading to impaired spermatogenesis. Lipid nanoparticles (LNPs) have emerged as mRNA delivery vehicles with minimal risk of genome integration; however, their ability to selectively deliver mRNA to specific cell types remains limited. To overcome this, microRNA (miRNA) target sequences were incorporated into mRNA constructs to restrict expression specifically to germ cells. Using pyruvate dehydrogenase E1 subunit alpha 2 (PDHA2) knockout …