Digital Commons Network^™

Towards A Comprehensive Model Of Compassion Fatigue In The Animal Welfare Community, Elizabeth Ellis

Browse all Theses and Dissertations

The COVID-19 pandemic highlighted the stress endured by those in caring professions and emphasized the impact that compassion fatigue and burnout have on helping professionals’ well-being and retention (J. Huang et al., 2024; Volk et al., 2022). However, researchers often have failed to adequately distinguish between compassion fatigue and burnout (e.g. Boyle, 2011). Additionally, researchers have overlooked the animal welfare community (e.g., Figley & Roop, 2006) in favor of focusing on human healthcare workers. Thus, the purposes of my study were to 1) examine whether emotional exhaustion and compassion fatigue were related but distinct phenomena and 2) propose and examine …

Characterization Of Atr Kinase Function In Quiescent Keratinocytes Exposed To Solar Simulating Uv Radiation, Mohamed Sameer Cholakkathody

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This study examines the role of Ataxia Telangiectasia and Rad3-related kinase in quiescent human keratinocytes exposed to solar-simulated UV radiation (SSL). The ATR inhibitor VE-822 did not significantly affect cell viability in the absence of UV exposure, showing that ATR kinase activity is not essential for quiescent cell survival in the absence of additional genotoxic stress. After SSL exposure, ATR inhibition did not impact acute cell viability but reduced the cells’ long-term ability to proliferate. Western blot analysis demonstrated that VE-822 potently suppressed phosphorylation of ATR target proteins KAP1 and CHK2 in a dose-dependent manner after SSL exposure, confirming strong …

Reducing Operator Training Time Through Virtual Reality: A Case Study On The Lpkf Protomat E44 Machine, Joshua C. Patel

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This thesis presents the development of an immersive virtual reality (VR) simulation that replicates the operation of the LPKF ProtoMat E44 PCB milling machine. Aimed at reducing operator training time and improving procedural understanding, the simulation offers an interactive and realistic environment where users can safely engage with machine workflows and start-up sequences. The emphasis is on accurate representation, usability, and maintaining immersion to support intuitive learning. Although formal evaluation is outside the scope of this work, the system is designed to serve as a foundation for cost-effective, scalable training in technical and manufacturing contexts, offering a modern alternative to …

Vagus Nerve Stimulation Ameliorates Cognitive Impairment Caused By Hypoxia, Birendra Sharma

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Hypoxia disrupts brain function due to the high demand for oxygen, leading to significant cognitive impairments. While vagus nerve stimulation (VNS) has been shown to enhance cognition, its ability to counteract hypoxia-induced deficits remains unclear. In this study, male Sprague–Dawley rats were assigned to sham, hypoxia, or VNS + hypoxia groups, with VNS delivered during hypoxia (8% oxygen) using biphasic pulses (100 μs, 30 Hz, 0.8 mA). Cognitive performance was evaluated using multiple behavioral paradigms, and hippocampal tissue was analyzed for neurotrophin expression through quantitative PCR and immunohistochemistry. Among the behavioral measures, hypoxia specifically impaired performance on the passive avoidance …

Distinct Forms Of Myotonia In Pharmacologic And Genetic Mouse Models At Room And Body Temperature, Rola Benammar

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Myotonia congenita (MC) is a genetic disorder caused by loss-of-function mutations in the ClC-1 chloride channel, leading to muscle hyperexcitability and symptoms of transient stiffness and weakness. Work in hyperkalemic periodic paralysis (HKPP), a disorder with overlapping clinical features, has shown that myotonia can arise from two distinct mechanisms: a sustained form and a transient post-stimulus form, which have opposite temperature dependence. In HKPP, sustained myotonia worsens at elevated temperatures, whereas transient myotonia is exacerbated by cooling. This study tested whether these two mechanisms also contribute to myotonia in MC. Ex vivo force recordings were performed in extensor digitorum longus …

Determining The Genetic Population Structure Of The Endangered Scirpus Ancistrochaetus Using Genomic Sequences, Kayci Johnson

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Wetlands are biodiverse ecosystems across the world, and they are being lost at alarming rates due to fragmentation and anthropogenic stressors. Many wetland plants are endangered or threatened due to wetland decreasing numbers. Scirpus ancistrochaetus is an endangered wetland species in the northeastern United States. It is most commonly found in lowlands and forested ecosystems. In this study, I used 105 polymorphic loci obtained from double-digest restriction site associated DNA sequencing (ddRAD-seq), a conservation genetics tool, to determine conservation units, gene flow, kinship, and isolation-by-distance patterns. Discrete populations were identified in New England and the southern part of the species’ …

Generative Adversarial Networks (Gans) For High-Dimensional Biological Data, Harigovind Harikumar

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This thesis investigates the application of Generative AI models, mainly Generative Adversarial Network (GAN) models to high dimensional and low sample size biological datasets like Motion Sickness, Breast Cancer, Crohn, and Melanoma. We utilized and compared three generative AI frameworks: Vanilla GAN, Wasserstein GAN (WGAN), Locality-Sensitive Hashing GAN (LSH-GAN) and Omics GAN. To address the challenges associated with high-dimensionality and low sample size, which was leading to very poor outputs of biological synthetic samples, we came up with an approach to stop the model when it reaches its saturation level. That is, we printed the loss plots to see where …

Benthic Algal Biomass And Productivity Across Depth Gradients In Lakes Michigan And Erie, Ahmed Ogidan

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Benthic primary production is poorly quantified in the Laurentian Great Lakes relative to phytoplankton-based production. We measured benthic chlorophyll and benthic primary productivity on soft sediments and Dreissena shells along depth gradients in Lakes Erie (2024) and Michigan (2025) during EPA Cooperative Science and Monitoring Initiative cruises. We measured benthic chlorophyll fluorometrically and estimated benthic primary productivity using non-invasive oxygen exchange incubations. We used PAM fluorometry to characterize photosynthetic-irradiance relationships on mussel shells and sediments in Lake Michigan. In Lake Erie, sediment chlorophyll ranged from 20 to 150 mg m⁻², with highest values in the central basin. In Lake Michigan, …

The Role Of Trpm7 In Mouse Development And Immune Cell Function, Jananie Rockwood

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Transient receptor melastatin 7 (TRPM7) functions both as an ion channel and a protein kinase. TRPM7 has been implicated in Mg2+ homeostasis, embryogenesis, cardiac automaticity, and immunity. The purpose of this research was to deepen our understanding of TRPM7 channel and kinase functions. To this end, we used two transgenic mouse models: the TRPM7 gain-of-function (GOF) and TRPM7 kinase-dead (KD) mice to address the consequences of increased channel activity and kinase inactivation, respectively. Global deletion of TRPM7 or the kinase domain alone are embryonic lethal, therefore, we used the TRPM7 GOF mouse to investigate germline transmission. We examined embryo development …

Induced Reduction Of N-Glycosylation Leads To Heart Failure, Anthony M. Young

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Cardiovascular disease is the leading cause of death and contributes to the increasing global prevalence of heart failure (HF). N-glycosylation is a common co-/post-translational modification where branching oligosaccharides are bound to the extracellular domain of membrane proteins. This creates a diverse range of glycan structures and requires the coordination of hundreds of regulated genes. Inherited mutations in glycan synthesis frequently present with cardiomyopathies leading to HF with reduced ejection fraction (HFrEF). Additionally, gene expression studies of HFrEF patients have shown altered expression of glycosylation-related genes, including alpha-1,3-mannosyl-glycoproten 2-beta-N acetlyglucosaminyltransferase (Mgat1). This gene encodes N-acetylglucosaminyl transferase 1 (GlcNAcT1) which is required …

The Impact Of Ahr And Hs1.2 Enhancer Genetic Variations On Igh Expression And Antibody Production In Human B Cells, Mili Santosh Bhakta-Yadav

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Antibody production is an essential component of the immune response against pathogens. The immunoglobulin heavy chain (IgH) gene codes for the heavy chain of antibodies. The IgH constant regions Cμ, Cδ, Cγ1-4, Cα1-2, and Cε encode the five major classes of antibodies, i.e., IgM, IgD, IgG1-4, IgA1-2, and IgE, respectively. The transcription of the IgH gene and class switch from IgM to other isotypes is regulated by two 3’ IgH regulatory regions (3’IgHRRs), each of which is a cluster of three enhancer regions (hs3, hs1.2 and hs4). The genetic variations in the hs1.2 enhancer have been identified; a ~53 bp …

Characterizing The Microvesicle Particles From Keratinocytes Stimulated With Multiple Stressors, Muslima Begum

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Many types of environmental and physical stressors act upon the skin and can initiate inflammation, systemic effects, and even damage to internal organs. Recent studies have identified that these harmful events are driven by the release of subcellular microvesicle particles (MVPs), an inflammatory process promoted by the glycerophosphocholines-derived lipid mediator, Platelet-activating Factor (PAF). These harmful effects are driven by the release of MVPs, a process promoted by the inflammatory lipid mediator, PAF. We have previously demonstrated that exposure of human HaCaT keratinocyte and mouse skin to stressors such as thermal burn injury, ultraviolet B (UVB) radiation, and topical photodynamic therapy …

The Effectiveness Of Longitudinal Rumble Strips On Indiana Roads, Mario A. Barahona, Qiming Guo, Vamsi Krishna Bandaru, Mario A. Romero, Andrew P. Tarko

JTRP Technical Reports

Rumble strips are designed and deployed to reduce run-off-road and head-on crashes by alerting drivers about near-lane departures. Although they have been widely used, their operational safety effectiveness still needs to be investigated under various operational conditions. Rumble strips may have different widths and be installed on edge, shoulder, center, or in any combination of these locations. To perform a comprehensive analysis of rumble strips’ safety effectiveness on rural two-lanes roads across Indiana, both statistical analysis and field test were performed. To statistically analyze this problem, a dataset for road segments with installed rumble strips including crash data, strips’ locations, …

Diving Into Watershed Science And Education: Blending Science, Storytelling, And Professional Practice In Northern Michigan, Mara Clare Pellerito

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio expands understanding of the relationship between watershed education and science through storytelling, lived experiences, and research. In northern Michigan, the invasive Myriophyllum spicatum threatens watershed health by forming dense patches that block sunlight, exclude native plants and wildlife, and retain harmful nutrients later released by herbicide treatment. The Lake Leelanau Lake Association has managed this species with preventative and restorative practices since 2020, and this portfolio examines their results through scientific study and practical experience from the summers of 2024 and 25. It also explores how education serves as a stepping stone from childhood curiosity to a lifetime …

Impact Of Sensory Diets On Occupational Performance, Kyndra Holloway, Cassandra Howard, Makena Collin, Princess Pillos

Occupational Therapy | MSOT Capstone Projects

This study investigates the impact of individualized sensory diets on children’s occupational performance in daily life. Sensory diets are structured, child-specific interventions designed to facilitate improved sensory processing by integrating activities into established routines. They involve a tailored home program plan, consistent application, and interventions aligned with the child’s specific sensory needs (Wilbarger, 1995).Using a multiple single-case study design, this research examined the outcomes of sensory diets prescribed alongside direct occupational therapy (OT) services for four white male children aged 3 years, 11 months to 5 years, and 8 months with neurodevelopmental disorders.

Participants were recruited through Developmental FX (DFX) …

How South Dakota Can Criminalize Child Sexual Grooming, Jackson Marnette

South Dakota Law Review

In 2023, the South Dakota Legislature proposed and rejected Senate Bill 94, which would have criminalized child sexual grooming. South Dakota, like most states, lacks a law that effectively deters potential child sexual abusers from initiating the child sexual abuse process. Other states’ grooming laws have been challenged on constitutional grounds with differing results. This article considers the benefits of grooming laws, the pros and cons associated with other states’ passed legislation, and any issues with Senate Bill 94’s language. The article concludes with a legislative proposal based on child sexual grooming academic theory.

Great Lakes And Its Regional Climate In The Future, Miraj Bhakta Kayastha

Dissertations, Master's Theses and Master's Reports

The overarching objective of this dissertation is to enhance our predictive understanding of the Great Lakes regional climate by utilizing advanced modeling techniques and provide comprehensive insights into the future of the Great Lakes. This dissertation focuses on four areas pertinent to the future of the Great Lakes hydroclimate and extreme events, beginning with the derivation of robust water level projections for the Great Lakes in Chapter 2. Using a regional climate modeling system with a two-way coupled three-dimensional (3D) hydrodynamic lake and ice model for the Great lakes, we analyze long-term future changes in the over-lake precipitation, lake evaporation, …

From Conscientious French Canadian To Enterprising American: Making Memory & Measuring Social Mobility Of French Canadians 1880-1940, Brooke S. Schwaderer

Dissertations, Master's Theses and Master's Reports

This thesis studies the social mobility of French-Canadian immigrants to the Keweenaw Peninsula 1880-1940 and memory among their descendants to explain how French-Canadian culture in the Keweenaw faded over time. Oral histories were conducted to gain an understanding of the current French-Canadian culture in the Keweenaw, understand how the current generation perceives changes in culture over time, and provide possible explanations for why French-Canadians thrived in the Keweenaw. Tax records from the Michigan Technological University Archives and social mobility scores, mother tongue, and homeownership information from the United States census was analyzed to measure language loss, and the social mobility …

A Review Of The Utilization Of Comics In Research And The Potential For Graphic Medicine Integration In Health Science Communication, Nagatarang Nimmathota

Honors Undergraduate Theses

Communication is a vital part of research, both during its conduction and the dissemination of its findings. This can be difficult to achieve due to factors like knowledge disparity, technical jargon, and differing backgrounds. This narrative literature review draws from databases like PubMed, ScienceDirect, and others to examine the current utilization of graphic medicine in research and its effects on health research communication. This review found that the integration of graphic medicine can help alleviate those issues by simplifying complex topics into engaging visual narratives or comics for consumption by research participants and the public. Additionally, the use of graphic …

Comparative Semiotic Analysis Of Non-Verbal Communication: Apis Mellifera Waggle Dance And Human Kinesic Signaling Systems, Nishtha Tikalal

Honors Undergraduate Theses

There are many parallels between two seemingly disparate forms of non-verbal communication: the waggle dance of Apis mellifera (honeybees) and human kinesic signaling systems. Through a comparative semiotic analysis, this research aims to conduct a comparative semiotic analysis, investigating structural and functional similarities between these communication methods, challenging anthropocentric assumptions about meaning making in the natural world. This research employs a meta-synthesis approach, drawn from a methodological literature review to examine historical representations of bee-human relationships, semiotics of non-verbal communication, and the specific mechanisms of the waggle dance and human kinesics. This methodology involves systematic categorization and analysis of extracted …

A Survival Horror Video Game's Impact On Visual Attention, Alicia D. Sprague

Honors Undergraduate Theses

The current study’s main research question was whether playing a survival horror video game increases the visual selective attention of a player. This project examined how visual attention and anxiety levels differ after playing a survival horror video game and whether an individual’s gaming preferences affect these concepts. The research consisted of the preliminary evaluation of participants’ visual attention abilities and anxiety levels through psychological tasks. Participants then played Resident Evil 4: Chainsaw Demo, the selected survival horror video game for this study. After playing the demo, participants repeated the previous psychological tasks, and their results were assessed. Results …

The Aerodynamics Of Bird Perching: Understanding Wing And Body Interactions In Pigeon Flight, Anirudh Sriram

Honors Undergraduate Theses

During landing, birds often execute a perching maneuver. The perching maneuver refers to the complex series of actions that birds, and pigeons in particular, will perform when landing. They will typically decelerate by pitching their body to a high angle of attack and spreading their wings. It is believed to help achieve better control and reach optimal lift and drag coefficients. This study seeks to better understand the vortex interactions between the main and tail wings during this maneuver. However, it is still an unexplored phenomenon. Thus, two bird models were conceived to analyze it, one with and one without …

Digital Recess, Screen Time Split: The Impact Of Online Schooling On Recreational Screen Time And Their Dual Impact On Anxiety, Meagan Allender

Honors Undergraduate Theses

This study explores the influence of online schooling, anxiety, and recreational screen time in college aged students. Previous studies have shown a positive correlation between screen usage and anxiety scores, assessing either online school or total screen time on anxiety. However, no study had looked at the correlation between online schooling and recreational screen time, nor had any study assessed both their effects on anxiety at the same time. Using a sample of 71 participants, a bivariate regression was conducted to evaluate the correlation of each type of screen time with one another, then another regression was run to assess …

Investigating The Effects Of A Psychoplastogen On Depressive-Like Behaviors In Huntington Disease Model Mice, Kaleigh M. Hanley

Honors Undergraduate Theses

Huntington Disease (HD) is a neurodegenerative disorder caused by an expansion in the trinucleotide CAG repeat on exon 1 of the huntingtin gene. In HD one of the first symptoms is often depression. In cases where SSRIs fail, treatments for treatment-resistant depression often become a patient’s only option. These rigorous treatments, such as electroconvulsive therapy, are not suitable for this patient population as it can worsen motor symptoms. In order to search for potential alternatives, we queried whether depressive-like behavior could be reduced in Hu97/18 and Q175FDN HD mice by administering tabernanthalog, a non-hallucinogenic psychedelic analog. Our study is not …

Comparative Efficacy Of Hallucinogens In Treating Mood Disorders Through A Meta-Analysis Of Symptom Reduction, Dosage, And Duration, John Marco D.F. Muniz

Honors Undergraduate Theses

Background: Hallucinogens including psilocybin, lysergic acid diethylamide (LSD), ketamine, N,N-dimethyltryptamine (DMT) (as ayahuasca), have re-emerged as potential rapid-acting treatments for mood disorders. We conducted a meta-analysis of placebo-controlled trials evaluating their efficacy in depression and anxiety disorders. Methods: A systematic review identified 12 trials (Total ≈ 670) meeting inclusion criteria (randomized, placebo-controlled). Data on Cohen’s d and Hedges’ g effect sizes for depression- and anxiety-related outcomes were extracted. We computed pooled effect sizes (weighted by sample size and inverse variance), performed subgroup analyses by drug, diagnosis, follow-up duration, and outcome measure type, and assessed heterogeneity (I², Q …

Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications, Agastya Mittal

Honors Undergraduate Theses

Ceria nanoparticles' capabilities to defend cells against oxidative stress through superoxide dismutase activity are well-documented. Ceria nanoparticles demonstrate a ratio between 3⁺/4⁺ oxidative states on the surface of the particles to exhibit oxygen vacancies, a feature that allows these particles to scavenge Reactive Oxygen Species (ROS) in times of Oxidative Stress. Oxidative stress arises from many wounds in the body, such as wounds in the skin, and can have significant impacts on the health of an individual. Even when receiving treatment for the skin wound, ROS can circulate from around the wound, be generated from an imbalance …

Investigating The Role Of Prostasin In Angiogenesis: A Chorioallantoic Membrane Model Approach, Zaima Aline

Honors Undergraduate Theses

Prostasin, also known as PRSS8 or CAP1, is a glycosylphosphatidylinositol (GPI)-anchored extracellular serine protease involved in various physiological and pathophysiological processes. Prostasin expression is observed during key phases of trophoblast invasion and placental development, critical steps in embryo implantation in Rhesus monkeys. This suggests a role for prostasin in extracellular matrix remodeling and tissue invasion, both essential for a healthy pregnancy. Moreover, prostasin appears vital for development as studies in mice show that a germline knockout of the gene leads to significant placental defects and eventual embryonic death, highlighting its importance in vascular and structural development within the placenta.

Building …

Examining The Effect Of A High Fat Diet On The Expression Of Adipokines In A Murine Model Of Barrett's Esophagus, Saagar A. Shah

Honors Undergraduate Theses

Chronic acid reflux results in injury to the esophagus and the development of Barrett’s Esophagus (BE). BE elevates the lifetime risk for a patient to develop Esophageal Adenocarcinoma (EAC). Clinically, one of the main risk factors for BE and EAC is obesity, which alters the secretion of inflammatory cytokines by adipocytes, also referred to as adipokines. Conflicting reports have been made to the expression of adipokines and their receptors in the progression to esophageal cancer. Utilizing an inflammation-based mouse model for BE, we hypothesize that alterations in the expression of adipokines and their receptors favor an inflammatory environment associated with …

Evaluating Coffee And Caffeine Intake In Adults With Cardiovascular Disease: A Comparative Literature Review, Adam Harrington

Honors Undergraduate Theses

Coffee is among the most commonly consumed beverages worldwide, and its bioactive components, including caffeine, affect the cardiovascular system through multiple physiological mechanisms. Patients with cardiovascular disease are typically advised to limit coffee and caffeine consumption because of potential cardiovascular harm, but emerging research challenges this recommendation. This review evaluates recent evidence regarding consumption of whole coffee, caffeine, or decaffeinated coffee in adults with established cardiovascular disease. Database searches conducted across three platforms for studies published after December 2021 yielded 360 records. Following screening against inclusion criteria, 11 studies were reviewed included in the final review. The studies showed variable …

The Swiping Desire: Intimacy, Libidinal Capitalism, And The Digital Subject In The Tinder Swindler, Chanif Ainun Naim

Masyarakat: Jurnal Sosiologi

This article examines how dating applications operate as libidinal infrastructures that restructure and commodify intimacy within platform capitalism, using The Tinder Swindler as a cultural case study. Employing a visual-narrative approach within the framework of Critical Discourse Analysis, the film is analyzed to reveal the structural exploitation of user affect and desire. Grounded in Lacanian psychoanalysis and Baudrillard’s simulation theory, the study argues that these platforms capitalize on the subject’s ontological lack (manque) which fuels desire as the desire for the Other’s desire. This psychic lack sustains a perpetual pursuit of recognition that can never be fulfilled. The swindler’s hyper-curated …