Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 21241 - 21270 of 22947

Full-Text Articles in Entire DC Network

Nuclear Destabilisation – A Possible Genesis Of Cancer?, Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal Jan 2025

Nuclear Destabilisation – A Possible Genesis Of Cancer?, Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal

Research outputs 2022 to 2026

This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying trait of this disease. The tight regulation of innate cell mechanical properties raises the possibility that destabilisation of the cell drives tumour formation in an attempt to restore cell mechanical homeostasis. With losses in cell stiffness more pronounced at the cell nucleus, we hypothesise that destabilisation occurs within the nucleus, likely within the …


Varying Vulnerabilities: Seagrass Species Under Threat From Prolonged Ocean Warming, Marnie L. Campbell, Chi T.U. Le Jan 2025

Varying Vulnerabilities: Seagrass Species Under Threat From Prolonged Ocean Warming, Marnie L. Campbell, Chi T.U. Le

Research outputs 2022 to 2026

Understanding the response of various seagrass species to prolonged elevated water temperatures is crucial for effective management and seagrass species restoration amid increasing climate change-induced ocean warming and marine heat waves. This is especially important in intertidal seagrass meadows, where heat can penetrate substrate depths of up to 50 cm. We assessed and contrasted the responses of five intertidal species—Zostera muelleri Irmisch ex Asch, Halophila ovalis (R.Br.) Hook f., Halodule uninervis (Forssk.) Asch, Halophila decipiens Ostenf., and Halophila spinulosa (R.Br.) Asch—over a month of elevated temperatures by examining rhizome growth, number of living shoots, root development, and sprig survival. While …


Volumetric Comparison Of Overall Brain And Neuropil Size Between Social And Non-Social Spiders: Exploring The Social Brain Hypothesis, Vanessa Penna-Gonçalves, Donald James Mclean, Nikolas J. Willmott, Michael B.J. Kelly, Jay R. Black, Elizabeth C. Lowe, Marie E. Herberstein Jan 2025

Volumetric Comparison Of Overall Brain And Neuropil Size Between Social And Non-Social Spiders: Exploring The Social Brain Hypothesis, Vanessa Penna-Gonçalves, Donald James Mclean, Nikolas J. Willmott, Michael B.J. Kelly, Jay R. Black, Elizabeth C. Lowe, Marie E. Herberstein

Research outputs 2022 to 2026

The social brain hypothesis predicts that the relative size of specific brain regions is driven by the cognitive capacity required to manage complex (social) situations. Spiders are intriguing models to test this hypothesis, as sociality is rare in this usually solitary and aggressive group. Here, we used microCT to compare the central nervous system and brain volumes between social and solitary females of the species in two taxonomic groups, huntsman and crab spiders. Overall, we found no difference in relative CNS and brain volume between social and solitary species. However, social huntsman spiders Delena cancerides had larger arcuate and mushroom …


Techno-Economic And Eco-Friendly Msw-Based Strategy To Reduce The Impact Of Rajshahi City Electric Vehicle Power Outage In Bangladesh, Shah Tanvir Alam Rimon, Md Shahriar Mohtasim, Md Golam Kibria, Mim Mashrur Ahmed, Barun K. Das Jan 2025

Techno-Economic And Eco-Friendly Msw-Based Strategy To Reduce The Impact Of Rajshahi City Electric Vehicle Power Outage In Bangladesh, Shah Tanvir Alam Rimon, Md Shahriar Mohtasim, Md Golam Kibria, Mim Mashrur Ahmed, Barun K. Das

Research outputs 2022 to 2026

Population growth, economic expansion, urbanization, and evolving consumer habits are driving a significant increase in municipal solid waste generation, placing Bangladesh under immense societal pressure to manage and dispose of this waste effectively. Numerous studies have examined municipal solid waste management practices in Bangladesh, yet the potential for utilizing the generated energy to charge electric vehicles (EVs) remains unexplored. Therefore, in this study, waste-to-energy technologies such as landfill gas recovery (LGR), incineration (INC) and anaerobic digestion (AD) were assessed for energy recovery, economic feasibility, and global warming potential in Rajshahi City Corporation, Bangladesh, to meet the extra electricity demand imposed …


Circulating Lipocalin-2 Across The Adult Lifespan, Carlie Bauer, Cassandra Smith, Sara Vogrin, Andrew S. Palmer, Mary Woessner, Shanie Landen, Macsue Jacques, Elizabeth Byrnes, Nir Eynon, Marc Sim, Joshua R. Lewis, Itamar Levinger Jan 2025

Circulating Lipocalin-2 Across The Adult Lifespan, Carlie Bauer, Cassandra Smith, Sara Vogrin, Andrew S. Palmer, Mary Woessner, Shanie Landen, Macsue Jacques, Elizabeth Byrnes, Nir Eynon, Marc Sim, Joshua R. Lewis, Itamar Levinger

Research outputs 2022 to 2026

Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts and renal tubular cells, is implicated in age-related diseases, including cardio-metabolic disease. To understand the role LCN2 may play in pathological states, we first need to elucidate the relationship between circulating LCN2 with indices of cardio-metabolic health during “normal” ageing. This study examined the relationship between serum levels of LCN2, age and cardio-metabolic measures across the adult lifespan in males and females. We conducted a pooled cohort analysis including 124 community-dwelling males (n = 52) and females (n = 72) (age 20 - 87 years, median BMI 25.92 (23.04, 29.81) kg/m2). Serum …


Value Incoherence Precedes Value Change: Evidence From Value Development In Childhood And Adolescence Across Cultures, Ella Daniel, Anat Bardi, Julie A. Lee, Ricarda Scholz-Kuhn, Einat Elizarov, Jan Cieciuch, Ariel Knafo-Noam, Alice Ramos, Michele Vecchione, Rene Algesheimer, Evelia Murcia Alvarez, Avital Ben Dror Lankry, Maya Benish-Weisman, Ricardo Borges Rodriques, Anat Chomsky, Patricia R. Collins, Eldad Davidov, Anna K. Doring, Stefanie Habermann, Dana Katsoty, Martin Kindschi, Elena Makarova, Gilda Marsicano, Kinneret Misgav, Thomas P. Oeschger, Leonor Pereira Da Costa, Joanne Sneddon, Iva Tendais, Louise Twito-Weingarten Jan 2025

Value Incoherence Precedes Value Change: Evidence From Value Development In Childhood And Adolescence Across Cultures, Ella Daniel, Anat Bardi, Julie A. Lee, Ricarda Scholz-Kuhn, Einat Elizarov, Jan Cieciuch, Ariel Knafo-Noam, Alice Ramos, Michele Vecchione, Rene Algesheimer, Evelia Murcia Alvarez, Avital Ben Dror Lankry, Maya Benish-Weisman, Ricardo Borges Rodriques, Anat Chomsky, Patricia R. Collins, Eldad Davidov, Anna K. Doring, Stefanie Habermann, Dana Katsoty, Martin Kindschi, Elena Makarova, Gilda Marsicano, Kinneret Misgav, Thomas P. Oeschger, Leonor Pereira Da Costa, Joanne Sneddon, Iva Tendais, Louise Twito-Weingarten

Research outputs 2022 to 2026

We test the theory that personality incoherence may instigate personality change in the context of personal values. Values’ near-universal organization makes value incoherence assessment straightforward. The study included 13 longitudinal samples from seven cultures (Australia, Israel Palestinian citizens, Israel Jewish majority, Italy, Poland, Portugal, and Switzerland), total N = 7,126, and T1 Mage ranging between 6 and 18. Each participant reported values between two- and six-times. Using unfolding analysis, we calculated the fit of the internal value structure of each participant at the first time point to the value structure in their sample (normative structure) and to the theoretical structure …


Transforming Transitions Ii: Building Children's Engagement In Learning At School, Lennie Barblett, Fiona Boylan, Amelia Ruscoe Jan 2025

Transforming Transitions Ii: Building Children's Engagement In Learning At School, Lennie Barblett, Fiona Boylan, Amelia Ruscoe

Research outputs 2022 to 2026

Building on the success of the Transforming Transitions project conducted with ten Western Australian Independent Schools (Barblett et al., 2023), this study extended the inquiry into school engagement and the transition process. The project was reimagined to deepen collaboration with schools, focusing on two key areas: first, fostering meaningful engagement with young learners and their families during the transition to school by drawing on their funds of knowledge; and second, centering the perspectives of children as active participants in their transition, acknowledging their experiences and the role of family-school engagement in shaping their sense of belonging.


Comparing Microct Staining And Scanning Methodology For Brain Studies In Various Sizes Of Spiders, Vanessa Penna-Gonçalves, Nikolas J. Willmott, Michael B.J. Kelly, Jay R. Black, Elizabeth C. Lowe, Marie E. Herberstein Jan 2025

Comparing Microct Staining And Scanning Methodology For Brain Studies In Various Sizes Of Spiders, Vanessa Penna-Gonçalves, Nikolas J. Willmott, Michael B.J. Kelly, Jay R. Black, Elizabeth C. Lowe, Marie E. Herberstein

Research outputs 2022 to 2026

Recent advances in microCT are facilitating the investigation of microstructures in spiders and insects leading to an increased number of studies investigating their neuroanatomy. Although microCT is a powerful tool, its effectiveness depends on appropriate tissue preparation and scan settings, particularly for soft, non-sclerotized tissues, such as muscles, organs, and neural tissues. As the application of microCT in spiders is only in its infancy, published protocols are often difficult to implement due to substantial size variation of the specimens. The present study was initiated to determine how to account for this variation. Our work builds on previous methods using microCT …


Diverged Populations Admixture Bolsters Genetic Diversity Of A New Island Dibbler (Parantechinus Apicalis) Population, But Does Not Prevent Subsequent Loss Of Genetic Variation, Rujiporn Thavornkanlapachai, Harriet R. Mills, Kym Ottewell, Cathy Lambert, J. Anthony Friend, Daniel J. White, Zahra Aisya, W. Jason Kennington Jan 2025

Diverged Populations Admixture Bolsters Genetic Diversity Of A New Island Dibbler (Parantechinus Apicalis) Population, But Does Not Prevent Subsequent Loss Of Genetic Variation, Rujiporn Thavornkanlapachai, Harriet R. Mills, Kym Ottewell, Cathy Lambert, J. Anthony Friend, Daniel J. White, Zahra Aisya, W. Jason Kennington

Research outputs 2022 to 2026

Translocating individuals from multiple source populations is one way to bolster genetic variation and avoid inbreeding in newly established populations. However, mixing isolated populations, especially from islands, can potentially lead to outbreeding depression and/or assortative mating, which may limit interbreeding between source populations. Here, we investigated genetic consequences of mixing individuals from two island populations of the dibbler (Parantechinus apicalis) in an island translocation. Despite a high level of genetic divergence between the source populations (FST ranges 0.33–0.64), and significant differences in body size, individuals with different ancestries were able to successfully interbreed in captivity and in the wild. However, …


Exploring The Relationship Between Melanopsin Gene Variants, Sleep, And Markers Of Brain Health, Ayeisha Milligan Armstrong, Eleanor O'Brien, Tenielle Porter, Vincent Dore, Pierrick Bourgeat, Paul Maruff, Christopher C. Rowe, Victor L. Villemagne, Stephanie R. Rainey-Smith, Simon M. Laws Jan 2025

Exploring The Relationship Between Melanopsin Gene Variants, Sleep, And Markers Of Brain Health, Ayeisha Milligan Armstrong, Eleanor O'Brien, Tenielle Porter, Vincent Dore, Pierrick Bourgeat, Paul Maruff, Christopher C. Rowe, Victor L. Villemagne, Stephanie R. Rainey-Smith, Simon M. Laws

Research outputs 2022 to 2026

INTRODUCTION: Melanopsin is a photopigment with roles in mediating sleep and circadian-related processes, which are often disrupted in Alzheimer's disease (AD). Melanopsin also impacts cognition and synaptogenesis. This study investigated the associations between melanopsin genetic variants, sleep, and markers of brain health. METHODS: Linear regression analyses examined the relationship of single-nucleotide polymorphisms (SNPs) within the melanopsin gene (OPN4), with cortical amyloid beta (Aβ), cognition, brain volumes, and self-reported sleep traits in cognitively unimpaired older adults. Further analyses assessed whether sleep traits x OPN4 SNP interactions were associated with markers of brain health. RESULTS: OPN4 SNPs rs2355009 and rs3740334 were associated …


Goldenbraid20 E Coli: A Comprehensive And Characterized Toolkit For Enterics, Matthew B Cooke, Kobie T Welch, Laura D Ramirez, Alice X Wen, David C Marciano, Christophe Herman Jan 2025

Goldenbraid20 E Coli: A Comprehensive And Characterized Toolkit For Enterics, Matthew B Cooke, Kobie T Welch, Laura D Ramirez, Alice X Wen, David C Marciano, Christophe Herman

Faculty, Staff and Students Publications

Modular cloning systems streamline laboratory workflows by consolidating genetic 'parts' into reusable and modular collections, enabling researchers to fast-track strain construction. The GoldenBraid 2.0 modular cloning system utilizes the cutting property of type IIS restriction enzymes to create defined genetic 'grammars', which facilitate the reuse of standardized genetic parts and assembly of genetic parts in the right order. Here, we present a GoldenBraid 2.0 toolkit of genetic parts designed to accelerate cloning in the model bacterium


Seeing, Feeling, And Hearing The World. A Regenerative Worldview: Rinyi, Pirlirr And Liyan, Kankawa Nagarra Knight, Anne Poelina, Sandra Wooltorton Jan 2025

Seeing, Feeling, And Hearing The World. A Regenerative Worldview: Rinyi, Pirlirr And Liyan, Kankawa Nagarra Knight, Anne Poelina, Sandra Wooltorton

Research outputs 2022 to 2026

In this communication, the Australian authors-two Indigenous women and one woman with Anglo-Celtic ancestry-take us into Western Australian Indigenous language and worldviews, to help us reach toward a regenerative worldview. Indigenous words such as rinyi, pirlirr, and liyan are explored to point us in a direction unfamiliar to many English speakers, to Land and Country as living and responsive. The authors notice that it is very difficult to describe these terms in English, because English language does not seem sufficiently capacious to describe the depth of relational being-with Country that Indigenous languages portray. This may be changing, as various Indigenous …


Detection Of Vkorc1 Single Nucleotide Polymorphisms Indicates The Presence Of Anticoagulant Rodenticide Resistance In Australia's Introduced Rats, Alicia F. Gorbould, Quinton F. Burnham, Michael T. Lohr, Annette Koenders Jan 2025

Detection Of Vkorc1 Single Nucleotide Polymorphisms Indicates The Presence Of Anticoagulant Rodenticide Resistance In Australia's Introduced Rats, Alicia F. Gorbould, Quinton F. Burnham, Michael T. Lohr, Annette Koenders

Research outputs 2022 to 2026

BACKGROUND: Anticoagulant rodenticides (ARs) are used globally to manage pest rodent populations. However, resistance to ARs in target rodent populations challenges pest control efforts and can increase risks to nontarget species. Resistance is frequently associated with nonsynonymous single nucleotide polymorphisms (nsSNPs) in the Vkorc1 gene, and this study carried out the first Vkorc1 survey of introduced rats on the Australian mainland. RESULTS: We identified three species of introduced rat using the cytochrome b gene across Brisbane, Melbourne, Perth and Sydney: Rattus rattus (Linnaeus 1758) (Lineage I); Rattus norvegicus (Berkenhout 1769); and Rattus tanezumi (Temminck 1844) (Lineage II). Three nsSNPs were …


Possibilities For Climate Change Adaptation Investments In Ghana: Exploring Private Sector Concerns And Perceptions About Policy Incentives, Jane Osei, Albert Ahenkan, Samuel Weniga Anuga Jan 2025

Possibilities For Climate Change Adaptation Investments In Ghana: Exploring Private Sector Concerns And Perceptions About Policy Incentives, Jane Osei, Albert Ahenkan, Samuel Weniga Anuga

Research outputs 2022 to 2026

Policy incentives can significantly boost private sector investment in climate change adaptation, especially in developing countries. Leveraging private sector resources, including human capital, financial assets, and technological innovations, is crucial for enhancing adaptation efforts. However, many private entities are reluctant to invest due to the perceived business risks associated with climate change. This hesitancy increases vulnerability in developing nations. This study examines the private sector's views in Ghana on policy incentives for climate adaptation investments and the barriers impeding their involvement. The findings show that corporate social responsibility, financial requirements, and access to relevant information are key motivators for private …


Belongingness, Trust And Connection: Arts Teachers In Western Australian Schools Create Safe Learning Spaces, Christina Gray, Lisa Paris, Geoffrey Lowe, Angela Perry, Lara Warwick Jan 2025

Belongingness, Trust And Connection: Arts Teachers In Western Australian Schools Create Safe Learning Spaces, Christina Gray, Lisa Paris, Geoffrey Lowe, Angela Perry, Lara Warwick

Research outputs 2022 to 2026

Central to this phenomenological inquiry is the question of how students’ fundamental needs of belonging, trust and connection are enacted in arts classrooms. Through qualitative semi-structured interviews, this research explores the teaching practices of 23 expert arts teachers in Western Australian schools, revealing strategies to sustain supportive and safe learning environments. The findings highlight the disconnection students face in their schools and the significance of trust in embracing diversity, cultivating quality relationships, and empowering student voice. Understanding these evolving practices can enable less experienced teachers to adapt arts-based approaches to foster inclusive spaces that prioritise student well-being and connection.


Children’S ‘Playbour’ As Influencers On Social Media: An Investigation Into The Legal And Ethical Issues Surrounding Kidfluencers, Catherine J. Archer, Kate Mirandilla Delmo Jan 2025

Children’S ‘Playbour’ As Influencers On Social Media: An Investigation Into The Legal And Ethical Issues Surrounding Kidfluencers, Catherine J. Archer, Kate Mirandilla Delmo

Research outputs 2022 to 2026

The legal and ethical concerns around children performing as social media influencers (SMIs) on various social media platforms have been in the spotlight, with the recent world-first decision by the Australian Government to ban social media for those under 16. Social media influence is big business across the globe, with organisations investing in working with influencers to promote their brands and/or ideas. Some children now ‘work’, often managed by their parents, to produce posts that promote brands and ideas on behalf of organisations–not only to other children but also to adults. This paper presents findings of two case studies of …


Joint Channel Allocation And Power Control For Mission-Critical Applications In Sustainable Underwater Acoustic Networks, Sadaf Vahabli, Iftekhar Ahmad, Quoc Viet Phung, Daryoush Habibi Jan 2025

Joint Channel Allocation And Power Control For Mission-Critical Applications In Sustainable Underwater Acoustic Networks, Sadaf Vahabli, Iftekhar Ahmad, Quoc Viet Phung, Daryoush Habibi

Research outputs 2022 to 2026

Underwater Acoustic Networks (UANs) are gaining popularity for underwater communication due to their long-range capabilities. However, they experience significant challenges, including limited bandwidth and spectrum overlap with marine mammal vocalizations, which raises concerns about the sustainable and ethical use of underwater acoustic resources. This study proposes an eco-friendly approach that integrates joint channel allocation and power control to minimize harmful interference with marine life while ensuring reliable communication for mission-critical applications, such as diver safety. To balance marine protection and communication reliability, this work introduces a strategy for intelligent spectrum management, where nodes first sense the acoustic spectrum to detect …


Learning-Associated Astrocyte Ensembles Regulate Memory Recall, Michael R Williamson, Wookbong Kwon, Junsung Woo, Yeunjung Ko, Ehson Maleki, Kwanha Yu, Sanjana Murali, Debosmita Sardar, Benjamin Deneen Jan 2025

Learning-Associated Astrocyte Ensembles Regulate Memory Recall, Michael R Williamson, Wookbong Kwon, Junsung Woo, Yeunjung Ko, Ehson Maleki, Kwanha Yu, Sanjana Murali, Debosmita Sardar, Benjamin Deneen

Faculty, Staff and Students Publications

The physical manifestations of memory formation and recall are fundamental questions that remain unresolved1. At the cellular level, ensembles of neurons called engrams are activated by learning events and control memory recall1-5. Astrocytes are in close proximity to neurons and engage in a range of activities that support neurotransmission and circuit plasticity6-10. Moreover, astrocytes exhibit experience-dependent plasticity11-13; however whether specific ensembles of astrocytes participate in memory recall remains obscure. Here we show that learning events induce c-Fos expression in a subset of hippocampal astrocytes, which subsequently …


Early Cerebrospinal Fluid Elevations Of Ptau-217 In Severe Traumatic Brain Injury Subjects, Hamad Yadikar, Firas H Kobeissy, Claudia Robertson, Spyridoula Tsetsou, John B Williamson, Damon G Lamb, Amy K Wagner, Todd Kibaugh, Shih-Han Kao, Zhifeng Kou, Robert D Welch, Jose-Miguel Yamal, Luis Leon-Novelo, Richard Rubenstein, Kevin K W Wang Jan 2025

Early Cerebrospinal Fluid Elevations Of Ptau-217 In Severe Traumatic Brain Injury Subjects, Hamad Yadikar, Firas H Kobeissy, Claudia Robertson, Spyridoula Tsetsou, John B Williamson, Damon G Lamb, Amy K Wagner, Todd Kibaugh, Shih-Han Kao, Zhifeng Kou, Robert D Welch, Jose-Miguel Yamal, Luis Leon-Novelo, Richard Rubenstein, Kevin K W Wang

Faculty, Staff and Students Publications

Introduction: Tauopathies, including Alzheimer's disease (AD), feature abnormal accumulations of hyperphosphorylated Tau protein; however, their biomarker potential in traumatic brain injury (TBI) is not well-defined. This study investigated whether cerebrospinal fluid (CSF) phosphorylated Tau at threonine-217 (pTau-217) could serve as an early biomarker for severe TBI (sTBI).

Methods: CSF samples from 26 sTBI patients, collected between 6 and 240 h post-injury, and 19 healthy controls were analyzed using an optimized direct enzyme-linked immunosorbent assay (ELISA; sensitivity < 4.7 pg/mL) for pTau-217 detection, complemented by Western blot validation. Temporal analysis, ROC curves, and trajectory clustering were used for interpretation.

Results: CSF pTau-217 levels were significantly elevated in sTBI patients at 6, 12, 18, 24, and 48 h post-injury compared to controls (p …


Fractalkine Inhibition Improves Survival And Reduces Tumor Immune Cell Infiltration In Orthotopic Murine Glioma Models, Eric A Goethe, Malcolm Mcdonald, Ashley Puentes, Karina Moreno, Yuhui Yang, Khatri Latha, Ganesh Rao Jan 2025

Fractalkine Inhibition Improves Survival And Reduces Tumor Immune Cell Infiltration In Orthotopic Murine Glioma Models, Eric A Goethe, Malcolm Mcdonald, Ashley Puentes, Karina Moreno, Yuhui Yang, Khatri Latha, Ganesh Rao

Faculty, Staff and Students Publications

No abstract provided.


Ai-Based Detection Of Coronary Artery Occlusion Using Acoustic Biomarkers Before And After Stent Placement, David Anderson Lloyd, Andrei Dragomir, Bulent Ozpolat, Biykem Bozkurt, Yasemin Akay, Metin Akay Jan 2025

Ai-Based Detection Of Coronary Artery Occlusion Using Acoustic Biomarkers Before And After Stent Placement, David Anderson Lloyd, Andrei Dragomir, Bulent Ozpolat, Biykem Bozkurt, Yasemin Akay, Metin Akay

Faculty, Staff and Students Publications

No abstract provided.


Revisiting Icd Therapy For Primary Prevention In Patients With Heart Failure And Reduced Ejection Fraction., Amin Yehya, Jose L Batista, Andrew J Sauer, Jonathan D Davis, Nasrien E Ibrahim, Roderick Tung, Biykem Bozkurt, Gregg C Fonarow, Sana M Al-Khatib Jan 2025

Revisiting Icd Therapy For Primary Prevention In Patients With Heart Failure And Reduced Ejection Fraction., Amin Yehya, Jose L Batista, Andrew J Sauer, Jonathan D Davis, Nasrien E Ibrahim, Roderick Tung, Biykem Bozkurt, Gregg C Fonarow, Sana M Al-Khatib

Faculty, Staff and Students Publications

Implantable cardioverter-defibrillators (ICDs) are recommended to reduce the risk of sudden cardiac death (SCD) in patients with heart failure with reduced ejection fraction (HFrEF). The landmark studies leading to the current guideline recommendations preceded the 4 pillars of guideline-directed medical therapies (GDMTs). Therefore, some have questioned the role of ICDs for primary prevention in current clinical practice. In this paper, the authors provide an overview of the current ICD recommendations, including the instrumental clinical trials, the risk of SCD as observed in clinical trials vs real-world scenarios, disparities in ICD use among different patient populations, the impact of contemporary GDMT …


Recognition And Management Of Persistent Chylomicronemia: A Joint Expert Clinical Consensus By The National Lipid Association And The American Society For Preventive Cardiology, Seyedmohammad Saadatagah, Miriam Larouche, Mohammadreza Naderian, Vijay Nambi, Diane Brisson, Iftikhar J Kullo, P Barton Duell, Erin D Michos, Michael D Shapiro, Gerald F Watts, Daniel Gaudet, Christie M Ballantyne Jan 2025

Recognition And Management Of Persistent Chylomicronemia: A Joint Expert Clinical Consensus By The National Lipid Association And The American Society For Preventive Cardiology, Seyedmohammad Saadatagah, Miriam Larouche, Mohammadreza Naderian, Vijay Nambi, Diane Brisson, Iftikhar J Kullo, P Barton Duell, Erin D Michos, Michael D Shapiro, Gerald F Watts, Daniel Gaudet, Christie M Ballantyne

Faculty, Staff and Students Publications

Extreme hypertriglyceridemia, defined as triglyceride (TG) levels ≥1000 mg/dL, is almost always indicative of chylomicronemia. The current diagnostic approach categorizes individuals with chylomicronemia into familial chylomicronemia syndrome (FCS; prevalence 1-10 per million), caused by the biallelic combination of pathogenic variants that impair the lipolytic action of lipoprotein lipase (LPL), or multifactorial chylomicronemia syndrome (MCS, 1 in 500). A pragmatic framework should emphasize the severity of the phenotype and the risk of complications. Therefore, we endorse the term "persistent chylomicronemia (PC)" defined as TG ≥1000 mg/dL in more than half of the measurements to encompass patients with the highest risk for …


Mutations In Retinal Cyclic Nucleotide-Gated Channels Identified In Familial Cases Of Inherited Retinal Dystrophies From Pakistan, Zainab Akhtar, Kiran Afshan, Yumei Li, Sumaira Altaf, Aleesha Asghar, Ume Sughra, Wajid Ali Khan, Haiba Kaul, Rui Chen, Sabika Firasat Jan 2025

Mutations In Retinal Cyclic Nucleotide-Gated Channels Identified In Familial Cases Of Inherited Retinal Dystrophies From Pakistan, Zainab Akhtar, Kiran Afshan, Yumei Li, Sumaira Altaf, Aleesha Asghar, Ume Sughra, Wajid Ali Khan, Haiba Kaul, Rui Chen, Sabika Firasat

Faculty, Staff and Students Publications

Purpose: Cyclic nucleotide-gated (CNG) channels are ligand-gated ion channels that transduce light signals into electrical signals in the retinal photoreceptors. Pathogenic variants in CNG channel genes are reported to cause inherited retinal dystrophies (IRDs). The current study used targeted panel sequencing to describe the mutational spectrum of CNG channel genes in familial cases of IRDs from eight consanguineous Pakistani families.

Methods: The current study included consanguineous Pakistani families with at least two affected members. DNA was extracted from whole blood samples by the phenol-chloroform method. Two affected members from each family were initially analyzed using targeted panel sequencing of 344 …


Diagnostic And Prognostic Value Of Cystatin C In Acute Coronary Syndrome: An Up-To-Date Meta-Analysis, Michal Pruc, Damian Swieczkowski, Basar Cander, Milosz J Jaguszewski, Sagar Galwankar, Salvatore Di Somma, Fatimah Lateef, Indrani Sardesai, Ayman El-Menyar, Michal Zembala, Jacek Kubica, Togay Evrin, Burak Katipoglu, Zubaid Rafique, Frank William Peacock, Lukasz Szarpak Jan 2025

Diagnostic And Prognostic Value Of Cystatin C In Acute Coronary Syndrome: An Up-To-Date Meta-Analysis, Michal Pruc, Damian Swieczkowski, Basar Cander, Milosz J Jaguszewski, Sagar Galwankar, Salvatore Di Somma, Fatimah Lateef, Indrani Sardesai, Ayman El-Menyar, Michal Zembala, Jacek Kubica, Togay Evrin, Burak Katipoglu, Zubaid Rafique, Frank William Peacock, Lukasz Szarpak

Faculty, Staff and Students Publications

Background: The role of Cystatin C (CysC) in the diagnosis and prognosis of cardiovascular disease, particularly acute coronary syndrome (ACS), is increasingly significant. The goal of this meta-analysis was to assess the diagnostic and prognostic value of CysC in patients with ACS, as well as its association with major adverse cardiovascular events (MACE), defined as mortality, myocardial infarction, heart failure, and stroke.

Methods: The present study is a systematic review and meta-analysis. Using PubMed, Web of Science, Cochrane Library, and Embase, a literature review of cohort and case control studies reporting MACE and using the terms ACS and Cystatin C …


Prognostic Value Of The Monocyte-To-High-Density Lipoprotein-Cholesterol Ratio In Acute Coronary Syndrome Patients: A Systematic Review And Meta-Analysis, Michał Pruc, Jacek Kubica, Maciej Banach, Damian Świeczkowski, Zubaid Rafique, William Frank Peacock, Zbigniew Siudak, Stanisław Surma, Prabath Nanayakkara, Krzysztof Kurek, Anne Lepetit, Łukasz Szarpak Jan 2025

Prognostic Value Of The Monocyte-To-High-Density Lipoprotein-Cholesterol Ratio In Acute Coronary Syndrome Patients: A Systematic Review And Meta-Analysis, Michał Pruc, Jacek Kubica, Maciej Banach, Damian Świeczkowski, Zubaid Rafique, William Frank Peacock, Zbigniew Siudak, Stanisław Surma, Prabath Nanayakkara, Krzysztof Kurek, Anne Lepetit, Łukasz Szarpak

Faculty, Staff and Students Publications

Background: Globally, diseases of the cardiovascular system stand as principal contributors to mortality and are expected to show an upward trajectory. The occurrence of acute coronary syndrome (ACS) has been linked to underlying inflammatory processes. The monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) has garnered significant attention as a prognostic biomarker, encapsulating the synergistic roles of inflammation and lipid metabolism in the pathophysiology of cardiovascular diseases, including ACS.

Aims: This meta-analysis examines the prognostic MHR ratio in ACS patients.

Methods: We systematically searched PubMed, Embase, Scopus, Web of Science, and the Cochrane Library databases to identify the relevant meta-analyses published before February 26, …


Playgrounds On Paper: Children’S Drawings As A Window Into Outdoor Play Preferences, Sebnem Cetken-Aktas, Serap Sevimli-Celik Jan 2025

Playgrounds On Paper: Children’S Drawings As A Window Into Outdoor Play Preferences, Sebnem Cetken-Aktas, Serap Sevimli-Celik

Research outputs 2022 to 2026

Children’s creativity in expressing themselves through traditional media, such as drawing, remains strong and reflects their keen awareness of their surroundings. Involving children in the design process provides a valuable opportunity to understand their perspectives. This study engaged 47 five-year-old children to explore their preferences for outdoor play environments through their drawings. The methodology involved analysing these drawings to gain insights into the children’s understanding and desires related to playground experiences. Conducted in multiple stages, the study revealed significant aspects of children’s preferences. The findings highlighted the children’s interest in imaginative features that extend beyond traditional playground structures, as well …


Sorghum And Sorghum-Based Products: Nutritional Composition, Prebiotic Potential And Health Benefits In Gut Microbiota Interactions, W. M.A.D.Binosha Fernando, Rasheed A. Abdulraheem, Kalmee Pramoda Kariyawasam, Amal Sudaraka Samarasinghe, W. M.Kendrea T. Fernando, Hannah Barnes, Malina Robertson, D. P.W. Jayatunga, B. G.D.N.K. De Silva, Vijay Jayasena Jan 2025

Sorghum And Sorghum-Based Products: Nutritional Composition, Prebiotic Potential And Health Benefits In Gut Microbiota Interactions, W. M.A.D.Binosha Fernando, Rasheed A. Abdulraheem, Kalmee Pramoda Kariyawasam, Amal Sudaraka Samarasinghe, W. M.Kendrea T. Fernando, Hannah Barnes, Malina Robertson, D. P.W. Jayatunga, B. G.D.N.K. De Silva, Vijay Jayasena

Research outputs 2022 to 2026

Sorghum (Sorghum bicolor L.) is a member of the Poaceae family and is the fifth most important crop globally. Sorghum grains (SGs) are rich in health-promoting macro- and micronutrients and phytochemicals. SGs are commonly consumed as food or as ingredients in food, especially in African countries. Therefore, food products such as ogi, bread and flour have been and are still being developed from SGs to provide nutritional and health benefits. However, the nutritional and prebiotic potential of SGs, especially the pigment pericarps, has not been fully exploited. This review describes micronutrients in different varieties of sorghum and the health benefits …


The Impact Of Film Factors On Destination Image And Travel Intention: A Comparative Study Between Vietnamese And Korean Film Industry, Gavin Northey, Hoa Hong Pham, Colette Gallagher, Steve D’Alessandro, Phan Thi Minh Thu, Quan Ha Minh Tran, Trang Thị Thùy Dương Jan 2025

The Impact Of Film Factors On Destination Image And Travel Intention: A Comparative Study Between Vietnamese And Korean Film Industry, Gavin Northey, Hoa Hong Pham, Colette Gallagher, Steve D’Alessandro, Phan Thi Minh Thu, Quan Ha Minh Tran, Trang Thị Thùy Dương

Research outputs 2022 to 2026

Film tourism represents a growing opportunity for destination marketers, yet limited research examines how specific filmic components within a film’s dramatic architecture influence destination image and travel intention. This study addresses this gap through a sequential explanatory mixed-methods design comprising three phases. First, a pre-test (n = 360) using exploratory factor analysis identified and validated four film components: plot, culture and tradition, scenery, and humanism. Second, a between-subjects quasi-experimental study with Vietnamese viewers (n = 792) employed partial least squares structural equation modeling to test how Korean versus Vietnamese films differentially influence domestic and international travel intentions. Third, semi-structured interviews …


The Perceptions Of Australian Identity By Year 5 And Year 6 Students In An Australian Independent School, Renae Nahajski, Dianne Chambers, Shane Lavery Jan 2025

The Perceptions Of Australian Identity By Year 5 And Year 6 Students In An Australian Independent School, Renae Nahajski, Dianne Chambers, Shane Lavery

Research outputs 2022 to 2026

The study described here explored the perceptions of eight Year 5 and Year 6 students of their Australian identity in an independent Western Australian metropolitan school. The epistemological approach for this research was constructivism with an interpretivist theoretical perspective. We aimed to understand the perspectives of the eight student participants by use of a phenomenological methodology. Semi-structured interviews and student drawn pictures provided the data. Results revealed common values, citizenship, and a strong sense of belonging as important attributes of the participants’ perceptions of their own Australian national identity. The results provide insights into how students perceive their sense of …