Digital Commons Network^™

Neurotensin Regulates Primate Ovulation Via Multiple Neurotensin Receptors, Andrew C. Pearson, Jessica S. Miller, Hannah J. Jensen, Ketan Shrestha, Thomas E. Curry Jr., Diane M. Duffy

Department of Biomedical and Translational Sciences Faculty Publications

Neurotensin (NTS), a small neuropeptide, was recently established as a key paracrine mediator of ovulation. NTS mRNA is highly expressed by granulosa cells in response to the luteinizing hormone (LH) surge, and multiple NTS receptors are expressed by cells of the ovulatory follicle. To identify the role of NTS receptors NTSR1 and SORT1 in ovulation in vivo, the dominant follicle of cynomolgus macaques (Macaca fascicularis) was injected with either vehicle control, the general NTS receptor antagonist SR142948, the NTSR1-selective antagonist SR48692, or the SORT1-selective antagonist AF38469. Human chorionic gonadotropin (hCG) was then administered to initiate ovulatory events. …

Interaction Of Cardiac Leiomodin With The Native Cardiac Thin Filament, Madison Little, Cristina M. Risi, Tania M. Larrinaga, Mason D. Summers, Tyler Nguyen, Garry E. Smith Jr., Jennifer Atherton, Carol C. Gregorio, Alla S. Kostyukova, Vitold E. Galkin

Department of Biomedical and Translational Sciences Faculty Publications

Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere. Therefore, the maintenance of thin filament length is crucial for myocardium function. The thin filament is comprised of an actin backbone, the regulatory troponin complex and tropomyosin that controls interactions between thick and thin filaments. Thin filament length is controlled by the tropomodulin family of proteins; tropomodulin caps pointed ends of thin filaments, and leiomodin (Lmod) promotes elongation of thin filaments by a “leaky-cap” mechanism. The broader distribution of Lmod on the thin …

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells, Ashley V. Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu

Department of Biomedical and Translational Sciences Faculty Publications

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy and tumor recurrence, which is primarily driven by breast cancer stem cells (BCSCs). BCSCs behave like stem cells and can self-renew and differentiate into mature tumor cells, enabling the cancer to regrow and metastasize. Key markers like CD44 and aldehyde dehydrogenase-1 (ALDH1), along with pathways like Wingless-related integration site (Wnt), Notch, and Hedgehog, are critical to regulating this stem-like behavior of BCSCs and, thus, are being investigated as targets for various new therapies. This review summarizes marker-dependent strategies for targeting …

Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas

Department of Biomedical and Translational Sciences Faculty Publications

Antibiotic resistance (AR) has become a critical global health crisis, threatening the efficacy of antibiotics and increasing healthcare costs, morbidity, and mortality. The One Health approach, which emphasizes the interconnectedness of human, animal, and environmental health, is increasingly recognized as an essential framework for addressing the complex drivers of AR. This review explores the mechanisms of resistance, such as genetic mutations, horizontal gene transfer, and biofilm formation, along with contributing factors such as the overuse of antibiotics in healthcare and agriculture. We assess both traditional and emerging strategies to combat AR, including antimicrobial stewardship, the development of new antibiotics, and …

Zic1 Is A Context-Dependent Medulloblastoma Driver In The Rhombic Lip, John J Y Lee, Ran Tao, Zhen You, Parthiv Haldipur, Anders W Erickson, Hamza Farooq, Liam D Hendriske, Namal Abeysundara, Cory M Richman, Evan Y Wang, Neha Das Gupta, Jennifer Hadley, Melissa Batts, Christopher W Mount, Xiaochong Wu, Alex Rasnitsyn, Swneke Bailey, Florence M G Cavalli, Sorana Morrissy, Livia Garzia, Kulandaimanuvel Antony Michealraj, Abhi Visvanathan, Vernon Fong, Jonelle Palotta, Raul Suarez, Bryn G Livingston, Miao Liu, Betty Luu, Craig Daniels, James Loukides, Anne Bendel, Pim J French, Johan M Kros, Andrey Korshunov, Marcel Kool, Fernando Chico Ponce De León, Mario Perezpeña-Diazconti, Boleslaw Lach, Sheila K Singh, Sarah E S Leary, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji-Yeoun Lee, Teiji Tominaga, William A Weiss, Joanna J Phillips, Shizhong Dai, Gelareh Zadeh, Ali G Saad, László Bognár, Almos Klekner, Ian F Pollack, Ronald L Hamilton, Young-Shin Ra, Wieslawa A Grajkowska, Marta Perek-Polnik, Reid C Thompson, Anna M Kenney, Michael K Cooper, Stephen C Mack, Nada Jabado, Mathieu Lupien, Marco Gallo, Vijay Ramaswamy, Mario L Suva, Hiromichi Suzuki, Kathleen J Millen, L Frank Huang, Paul A Northcott, Michael D Taylor

Faculty, Staff and Students Publications

Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma). Overexpression of ZIC1 suppresses the growth of group 3 medulloblastoma models, whereas it promotes the proliferation of SHH medulloblastoma precursor cells. SHH medulloblastoma ZIC1 mutants show increased activity versus wild-type ZIC1, whereas G4 medulloblastoma …

Procedural Terrain Generation: Noise Functions, Modern Methods, And Style Transfer, Hunter Barton

EWU Masters Thesis Collection

Procedural terrain generation, the algorithmic creation of digital terrain, finds use in multiple types of digital media. As the capabilities of modern computation increase, the ability to create more and more realistic terrains fully procedurally at scale improves. Modern methods of procedural generation have also overlapped with these advances, most notably advances in hardware. To account for this, a survey was done of modern methods for procedural terrain generation. Smooth procedural noise functions are one of the backbones of procedural terrain generation. Perlin noise, value noise, and fractal noise were explored in-depth. These noise functions were also tested for capabilities …

Identifying Notch-Regulated Genes Using A Specific Notch Signaling Inhibitor, Hammed Gafar

EWU Masters Thesis Collection

Bone remodeling is a dynamic process that requires a balance between bone resorption by osteoclasts and bone formation by osteoblasts to maintain skeletal integrity. Disruptions to this equilibrium can lead to pathological conditions such as osteoporosis. Osteoclasts originate from macrophages, and their differentiation is regulated by several signaling pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes specifically regulated by Notch. To address this limitation, this study employed IMR-1A, a selective Notch pathway inhibitor that disrupts the assembly of …

Bridging Prairie Restoration And Regenerative Agriculture With Compost Tea / The Rocket Incident: Post-Fire Soil Microbe Recovery On The Eastern Washington University Restoration Site, April Hersey

EWU Masters Thesis Collection

Inland Pacific Northwest prairie is an endangered ecosystem that has been reduced by conversion to agriculture. There is growing interest in the role of soil microorganisms in prairie ecosystems, which may be crucial for restoration of the plant community through interspecies interactions within the rhizosphere. One method for improving soil microorganism community composition is compost tea: enriched liquid compost extract. Compost tea is used in regenerative agriculture to improve crop yields and protect against pathogens. While research has supported compost tea application in regenerative agriculture, it has not been widely studied in the context of ecosystem restoration. After beginning a …

Igf-1 Impacts Neocortical Interneuron Connectivity In Epileptic Spasm Generation And Resolution, Carlos J Ballester-Rosado, John T Le, Trang T Lam, Anne E Anderson, James D Frost, John W Swann

Faculty, Staff and Students Publications

Little is known about the mechanisms that generate epileptic spasms following perinatal brain injury. Recent studies have implicated reduced levels of Insulin-like Growth Factor 1 (IGF-1) in these patients' brains. Other studies have reported low levels of the inhibitory neurotransmitter, GABA. In the TTX brain injury model of epileptic spasms, we undertook experiments to evaluate the impact of IGF-1 deficiencies on neocortical interneurons and their role in spasms. Quantitative immunohistochemical analyses revealed that neocortical interneurons that express glutamic acid decarboxylase, parvalbumin, or synaptotagmin 2 co-express IGF-1. In epileptic rats, expression of these three interneuron markers were reduced in the neocortex. …

Wireless Modular Implantable Neural Device With One-Touch Magnetic Assembly For Versatile Neuromodulation, Inho Kang, John Bilbily, Choong Yeon Kim, Chuanqian Shi, Manish K Madasu, Eun Young Jeong, Kyle E Parker, Do A Kwon, Bum-Joon Jung, Jae-Soon Yang, Juhyun Lee, Noah D L Kabbaj, Wonhee Lee, Jun-Bo Yoon, Ream Al-Hasani, Jianliang Xiao, Jordan G Mccall, Jae-Woong Jeong

2020-Current year OA Pubs

Multimodal neural interfaces open new opportunities in brain research by enabling more sophisticated and systematic neural circuit dissection. Integrating complementary features across distinct functional domains, these multifunctional neural probes have greatly advanced the interrogation of complex neural circuitry. However, introducing multiple functionalities into a compact form factor for freely behaving animals presents substantial design hurdles that complicate the device or require more than one device. Moreover, fixed functionality poses challenges in meeting the dynamic needs of chronic neuroscience inquiry, such as replacing consumable parts like batteries or drugs. To address these limitations, the modular implantable neural device (MIND) is introduced …

Contract To Kill: Gnas Mutation, Pratima Raut, Poompozhil Mathivanan, Surinder K. Batra, Moorthy P. Ponnusamy

Journal Articles: Biochemistry & Molecular Biology

The mutation in Gsα-coding GNAS exons, popular as gsp oncogene, is the most frequent mutation across all heterotrimeric G proteins involved in oncogenesis. GNAS R201, the most frequently mutated, followed by Q227, are found predominantly across various neoplasms and cancers such as IPMN, pituitary, thyroid, appendiceal, colorectal, etc. This review emphasizes the pivotal significance of the gsp oncogene and its ramifications underpinning the sustained addiction to GNAS mutation. Recent studies delineating the mechanistic intricacies that provide solid evidence of the profound impact of oncogenic GNAS on tumor formation, progression, and maintenance are highlighted. We have leveraged the discoveries of Gsα …

Balancing Digital Presents And Futures: Understanding First-Time Parents’ Practices, Plans And Perceptions Of ‘Quality’ And Risk In Young Children's Digital Engagements, Katrin Langton, Emma Jayakumar, Harrison W. See, Catherine Archer, Giselle Woodley

Research outputs 2022 to 2026

Parents in Australia today have to make decisions about what counts as appropriate digital media use for their young children in a cultural context characterised by conflicting advice, impractical screen use recommendations and risk-focussed media messaging. These conditions make it challenging for parents to purposefully approach and plan not only their children's current digital engagements but also their futures as digital citizens. How parents negotiate these tensions in managing their young children's digital presents, and how they approach planning for their digital futures, remains underexplored. This paper presents the findings of two rounds of qualitative interviews and three focus groups …

Design Of An Improved Robust Fractional-Order Pid Controller For Buck–Boost Converter Using Snake Optimization Algorithm, Seyyed Morteza Ghamari, Hasan Molaee, Mehrdad Ghahramani, Daryoush Habibi, Asma Aziz

Research outputs 2022 to 2026

With the increasing complexity of modern power systems, effective control of DC–DC converters has become crucial to ensure stability and efficiency. This paper focuses on optimizing the parameters of a known fractional-order proportional–integral–derivative (FOPID) controller for the control of a DC–DC buck–boost converter. The control of a DC–DC buck–boost converter is achieved using aFOPID approach. The gains of this technique have been enhanced utilizing the snake optimization (SO) algorithm. This converter exhibits unfavourable behaviour due to its non-minimum structure, necessitating a well-regulated controller to guarantee stability. The fractional concept is suggested here to enhance the dynamics of the classical PID …

Determinants Of Social Loneliness And Negative Coping Styles Of The Socially Lonely, Mark A. Facey, Craig P. Speelman

Research outputs 2022 to 2026

Almost everyone is affected by loneliness at some stage in their lives, and the long-term effects are dire, leading to depression, addiction, and suicide. To date, interventions have focused on external treatments with limited success. In this study, it is argued that underlying antecedents of social loneliness maintain negative behaviour, whereby it becomes chronic and problematic. Four intrinsic antecedents of social loneliness are examined (Secure and Insecure Attachment, Emotional Regulation Problems – Expressive Suppression, Unclear Self-Concept, and Neuroticism) along with negative (Ignoring and Withdrawing) behavioural coping styles. Ninety-six, mainly female (78%), psychology undergraduates were administered a battery of six questionnaires. …

Altering The Intracellular Trafficking Of Necator Americanus Gst-1 Antigen Yields Novel Hookworm Mrna Vaccine Candidates, Athos Silva De Oliveira, Leroy Versteeg, Neima Briggs, Rakesh Adhikari, Maria Jose Villar, Jeanna R Redd, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

Faculty, Staff and Students Publications

BACKGROUND: The antigen Na-GST-1, expressed by the hookworm Necator americanus, plays crucial biochemical roles in parasite survival. This study explores the development of mRNA vaccine candidates based on Na-GST-1, building on the success of recombinant Na-GST-1 (rNa-GST-1) protein, currently assessed as a subunit vaccine candidate, which has shown promise in preclinical and clinical studies.

METHODOLOGY/FINDINGS: By leveraging the flexible design of RNA vaccines and protein intracellular trafficking signal sequences, we developed three variants of Na-GST-1 as native (cytosolic), secretory, and plasma membrane-anchored (PM) antigens. After one immunization in mice, mRNA vaccines induced an earlier onset of antigen-specific antibodies compared to …

Dissemination And Implementation Of Injury Prevention Interventions: A Scoping Review For The Female, Woman And Girl Athlete Injury Prevention (Fair) Consensus, Brooke E. Patterson, Carly D. Mckay, Meghan L. Critchley, Destiny Lutz, Sallie M. Cowan, Nicholas Kolesky, Vanda White, Allison M. Ezzat, Andrew G. Ross, William M. Adams, Eva Ageberg, Clare L. Ardern, Marelise Badenhorst, Molly Coventry, Marc Olivier Dubé, Stacey Emmonds, Libby J. Gracias, K. Alix Hayden, Hanna Lindblom, Merete Møller, Christine Holm Moseid, Nancy Harrington, Dai Sugimoto, Evert Verhagen, Kate K. Yung, Phathokuhle C. Zondi

Research outputs 2022 to 2026

Objective: To synthesise evidence related to the dissemination and implementation (D&I) of injury prevention interventions for female, woman and/or girl (female/woman/girl) athletes. Design Scoping review. Data sources MEDLINE, APA PsycInfo, Cochrane Databases for Systematic Review, Cochrane Central Register for Controlled Trials Registry, EMBASE, CINAHL, SPORTDiscus, ERIC, ProQuest Dissertation and Theses Global. Eligibility Primary research including ≥25% female/woman/girl athletes of any age or people working with them (eg, coaches), participating in sports competition and/or performance, were eligible. Papers reporting D&I outcomes (eg, coach knowledge, adoption and maintenance) related to an injury prevention intervention and/or a factor (eg, coach beliefs) associated with …

Effects Of Multi-Ingredient Protein Supplementation Combined With Exercise Intervention On Body Composition And Muscle Fitness In Healthy Women: A Systematic Review With Multilevel Meta-Analysis, Chengyu Zhou, Muen Qiu, Zhuo Zeng, Qi Xie, Kai Xu, Henghao Yan, Bo Wang, Bopeng Qiu, Guoxin Shi

Research outputs 2022 to 2026

Objectives: This meta-analysis investigated whether multi-ingredient protein supplements (MIPS) combined with exercise improve body composition and muscle fitness in women. It also examined how participant characteristics, training protocols, and supplementation strategies might influence these outcomes. Methods: A systematic search of five electronic databases was conducted through February 2025 to identify randomized controlled trials evaluating the effects of MIPS combined with exercise training on body composition and muscle-related outcomes in women. A multilevel meta-analysis was performed to pool effect sizes, reported as standardized mean differences (Hedges’ g), with heterogeneity assessed through predefined subgroup analyses. Results: Nine randomized controlled trials involving 408 …

Maboo Liyan Boorroo–Good Spirit Country: Using Participatory Research Frameworks To Manage Indigenous Cultural Landscapes In A Time Of Environmental And Political Uncertainty, Martuwarra Riveroflife, Anne Poelina, Martuwarra River Keepers, Sven Ouzman, Tod Jones, Naomi Joy Godden, Martin Brueckner

Research outputs 2022 to 2026

Management of cultural landscapes has struggled to understand and adapt to Indigenous ways of managing heritage through a reciprocal duty of care. We argue that barriers to Indigenous cultural landscapes are threefold. First, conceptual barriers exist due to the prevalence of inappropriate heritage concepts and frameworks from the Global North. Second are relational barriers in the form of asymmetrical relationships of power between non-Indigenous heritage ‘experts’ and Indigenous individuals and communities. Third, political barriers present in neo-colonial politics are at odds with the goals of Indigenous movements. After introducing Martuwarra RiverOfLife and her co-authors, we review these barriers within a …

The Affective Milieu Of School Market Competition: Using Affect And Governmentality To Study Market Competition, Brad Gobby, Amanda Keddie, Jill Blackmore, Katrina Macdonald

Research outputs 2022 to 2026

This paper integrates insights from affect theory into Foucault’s governmentality framework to analyse school markets. Using a Deleuzian approach to affect, we theorise school markets as an affective milieu that composes the field of competition. Drawing on interviews with staff at two rival high schools, we highlight how an affective milieu that included threat, anxiety, insecurity, resentment and confidence shaped market dynamics. Our analysis shows that affective milieus reflect and reinforce power asymmetries in local school markets and are a condition for generating competitive practices to enhance schools’ capacities to affect and be affected. Our central point is to move …

Blurred Vision: Understanding Barriers To Initiating Collaborative Market Driving, Kim Feddema, Daniel Schepis, Liudmila Tarabashkina, Sharon Purchase

Research outputs 2022 to 2026

Purpose: This paper aims to examine why many producers of origin-bound products struggle to collectively drive increases in market value, despite shared interests. The authors apply a collaborative market driving (CMD) lens to the early stages of collective efforts, to identify the key motivators, visioning processes and explore why CMD can fail to initiate. Design/methodology/approach: The authors present a qualitative case study of the Western Australian monofloral honey industry. Data includes 64 producers’ and distributors’ online content and 30 interviews with stakeholders. Leximancer was used to map marketing communications, and participant narratives were thematically analysed using terroir and authenticity frameworks. …

Behavioral Responses To Underwater Noise, Christine Erbe, Capri Jolliffe, Renee Schoeman, Valeria Senigaglia, Cristina Tollefsen, Rebecca Wellard, Ann Bowles, Dorian Houser, Shyam Madhusudhana, Sarah A. Marley, Angela Recalde Salas, Chandra Salgado-Kent, Leah Trigg

Research outputs 2022 to 2026

This chapter presents an overview of physical and acoustic behavioral responses of marine mammals to underwater sounds. A literature review was undertaken, and data on received levels at the animal when certain types of responses were observed were compiled in an online supplementary spreadsheet. Based on this, an overview of responses was written, organized first by species and then by sound type. In-air and underwater sound sources were considered. The most studied sound types were mid-frequency sonar and acoustic deterrent devices and then impact pile driving and vessels. The most frequently reported response was avoidance, followed by changes in swim …

Innovation Through Conceptual Research: Tips For Stoking Curiosity, Jun Wen

Research outputs 2022 to 2026

Conceptual research represents a critical step in the theory-building process and contributes innovative ideas that inspire empirical studies. This feature article highlights the importance of such research in academia with examples drawn from the tourism literature. It also critically discusses issues related to publishing conceptual research in premier journals. By using a five-dimension framework of curiosity (i.e., deprivation sensitivity, joyous exploration, social curiosity, stress tolerance, and thrill seeking), scholars can assess researchers’ conceptual topics and readers’ responses when contemplating “what's new” to gauge a paper's publication potential. Several tips are offered to guide like-minded scholars in conducting sound conceptual research: …

The Careful Project: Evaluating The Acceptability Of Local Virtual Reality Experiences As A Leisure Activity For Residents In Aged Care, Davina Porock, Patricia Cain, Christopher Young, Julieanne Hilbers, Maria Bomm, Manonita Ghosh, Mandy Stanley

Research outputs 2022 to 2026

Objectives: The aim of this project was to evaluate the feasibility and acceptability of virtual reality (VR) as a leisure activity for people living in residential aged care. Virtual reality experiences may offer alternatives for residents with limited mobility, or during times when older people are unable to leave residential care. Methods: The intervention used VR videos delivered via a head-mounted device. Video content was created by a local artist specifically for use with older Western Australian adults and used local content. VR sessions were videotaped for analysis. The evaluation included structured observation of video content to assess mood and …

Kaartdijin Bidi (Learning Journey): Place-Based Cultural Regeneration At University, Sandra Wooltorton, Lauren Stephenson, Kathie Ardzejewska, Len Collard

Research outputs 2022 to 2026

Imagine being in a university that functions in a place-based culturally regenerative way. In this concept paper, the authors bring together theory, practice, and experience, in the service of transforming universities towards place-based cultural regeneration. At present, Australian universities operate using an economic philosophy of neoliberal corporatism characterised by hierarchical management strategies, competitive tendencies, patriarchal values, and discourse characterised by bifurcation or binary thinking. These features illustrate a worldview that is entangled with the meta crises of our times such as climate change, species loss, hatred/intolerance, and unfathomable violence. The authors consider ways of moving towards a place-based, Indigenous-informed, practical, …

Review Of Applications Of Deep Learning In Veterinary Diagnostics And Animal Health, Sam Xiao, Navneet K. Dhand, Zhiyong Wang, Kun Hu, Peter C. Thomson, John K. House, Mehar S. Khatkar

Research outputs 2022 to 2026

Deep learning (DL), a subfield of artificial intelligence (AI), involves the development of algorithms and models that simulate the problem-solving capabilities of the human mind. Sophisticated AI technology has garnered significant attention in recent years in the domain of veterinary medicine. This review provides a comprehensive overview of the research dedicated to leveraging DL for diagnostic purposes within veterinary medicine. Our systematic review approach followed PRISMA guidelines, focusing on the intersection of DL and veterinary medicine, and identified 422 relevant research articles. After exporting titles and abstracts for screening, we narrowed our selection to 39 primary research articles directly applying …

A Moving Cause: Travel Notes Towards Pilgrimage As Creative Writing Process, Elizabeth Reid Boyd

Research outputs 2022 to 2026

Pilgrimage Studies is a growing field across the arts and humanities, yet pilgrimage writing is not established as a distinct genre. In this article I share my exploration of pilgrimage as a creative writing process and potential genre. As a social scientist and a creative writer, my approach is qualitative and interdisciplinary, drawing upon an on-the-ground social constructivist perspective and definitions of genre as social action. This includes an ethnomethodological account of my practice that distils ten narrative and thematic elements in the pilgrimage writing process. These elements hinge on the leitmotif of pilgrimage writing being ‘a moving cause’, with …

Implementation Of A Coach-Supported Mhealth Intervention For Dementia Prevention In China: A Qualitative Study Among Chinese Participants And Coaches In The Prodemos Trial, Jinxia Zhang, Marieke P. Hoevenaar-Blom, Xuening Jian, Haifeng Hou, Siqi Ge, Carol Brayne, Esmé Eggink, Melanie Hafdi, Mingyue He, Guohua Wang, Wenzhi Wang, Wei Zhang, Yueyi Yu, Yixuan Niu, Jihui Lyu, Libin Song, Wei Wang, Youxin Wang, Eric P. Moll Van Charante, Manshu Song

Research outputs 2022 to 2026

Background Modifiable risk factors have been linked to 45% of dementia cases. Mobile health (mHealth) interventions targeting lifestyle-related risk factors with remote coaching have the potential to reach underserved high-risk populations globally. To date, little is known about the implementation of such interventions in China. Methods Fifty semi-structured interviews were conducted with 14 participants and 11 health coaches involved in the PRODEMOS trial. This trial investigated whether a coach-supported mHealth application intervention can reduce dementia risk in people aged 55–75 years with multiple risk factors. Interviews were conducted three months and 12–18 months into the intervention, focusing on implementation outcomes …

Ecological Resources Of A Heavily Modified And Utilised Temperate Coastal Embayment: Cockburn Sound, Peter J. Mitchell, Daniel E. Yeoh, Kurt N. Krispyn, Claire N. Greenwell, Sorcha Cronin-O’Reilly, Delphine B.H. Chabanne, Glenn A. Hyndes, Danielle Johnston, David V. Fairclough, Claire Wellington, Alan Cottingham, Gary Jackson, Jeffrey V. Norriss, Matias Braccini, Hector Lozano-Montes, Chandra P. Salgado Kent, Erin Clitheroe, Alissa Tate, James W. Penn, Marion Massam, Neil R. Loneragan, James R. Tweedley

Research outputs 2022 to 2026

Coastal environments and their associated biota provide numerous environmental, economic and societal services. Cockburn Sound, a temperate embayment on the lower west coast of Western Australia, is immensely important for the State and adjacent capital city of Perth. However, urbanisation and associated terrestrial and marine development has the potential to threaten this important ecosystem. This study collated published and unpublished data to review the current state of the ecological resources of Cockburn Sound and describe how they have changed over the past century. Post-WWII, the embayment began undergoing pronounced anthropogenic changes that limited oceanic water exchange, increased nutrient load, modified …

Global Patterns And Drivers Of Seagrass Biomass, Net Primary Production And Meadow Structure, Nicole R. Foster, Enric Gomis, Diana I. Montemayor, Simone Strydom, Miguel Angel Mateo, Eduard Serrano, Aurora M. Ricart, Martin Dahl, Ines Mazarrasa, Paulina Cisternas, Harry Whiteley, Elliott J. Bates, Viena Puigcorbé, Uxue Moreda, Mar Truc, Karina Inostroza, Rafael Huertas, Roisin Mccallum, Anna Lafratta, Chanelle L. Webster, Caitlyn M. O'Dea, Nicole E. Said, Carlos M. Duarte, Paul S. Lavery, Oscar Serrano

Research outputs 2022 to 2026

Aim: We decipher global patterns in seagrass growth and structure to advance seagrass science, facilitate multidisciplinary research, and promote effective management strategies and policy development for seagrass habitats. Location: Global. Time period: 1975 to 2024. Major taxa studied: Seagrasses—marine angiosperms. Methods: A global data set on seagrass total biomass, total net primary productivity (NPP), shoot density, and percent cover was compiled across 11 genera. We tested how these variables change across seagrass genera, life-history strategy, and geographic location; and then modelled the environmental drivers (temperature, nutrients, light availability) of the patterns observed. Results: The mean (±SE) total biomass of seagrasses …

Indigenous Wisdom For Regeneration: Reducing The Knowledge Gap, Sandra Wooltorton

Research outputs 2022 to 2026

The author of this paper uses Indigenous-informed literature and explores the use of a Multispecies Collaboratory to hear place-based voices and practice ways of knowing often denied value by the mainstream. In the Indigenous nation of Australia, the author sets out to learn ways to practice environmental education that build upon aeons of experience at caring for and responding to Country. The starting point is a 2024 paper with three claims, which are: a culture of epistemic violence and denial support the mainstream paradigm which silences Indigenous voices; an Indigenous-informed way of being with living-places can inform the core of …