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Of Mice And Men: The Regulation Of Herpes Simplex Virus 1 Latency In Mouse And Human Neurons, Paige N. Canova

Dartmouth College Ph.D Dissertations

Herpes simplex virus 1 (HSV-1) establishes latent infections in sensory neurons, from which HSV sporadically reactivates, often due to external stress and other stimuli. Latency and reactivation are commonly studied using in vivo and ex vivo models in a variety of hosts, as well as in vitro models including primary mouse neurons and neurons derived from human pluripotent stem cells (iPSCs). The criteria for authentically modeling HSV latency include the ability to easily manipulate host genetics and biological pathways, as well as mimicking the immune response and viral pathogenesis in human infections. Presently, there remains a pressing need for …

Substance Use In Justice-Involved Youth: The Roles Of Adhd And Cd, Avery Beatty

Open Access Dissertations

The present study aimed to investigate the relationships between ADHD, CD, and comorbid ADHD and CD on cigarette, cannabis, and alcohol use among justice-involved youth (JIY). Data for the present study were derived from a randomized controlled trial (RCT) that compared the effectiveness of various interventions in reducing cigarette use among youth at a state juvenile correctional facility in the Northeastern United States. The total sample (N = 302) comprised incarcerated and detained youth (n = 243) who ranged in age from 13 to 19 years (M = 16.01, SD = 1.01). Additionally, the present finding revealed that the total …

Advancing Sampling And Expanding Measurement Of Per- And Polyfluoroalkyl Substances In Natural Waters., Jarod Snook

Open Access Dissertations

Per- and polyfluoroalkyl substances (PFAS) have gained much attention over the last several years in environmental science and engineering communities. They pose a unique challenge: persistent and toxic like several other legacy pollutants, but with additional surfactant and amphiphilic properties increasing the complexity of chemical interactions. Thus, many scientific questions remain regarding the environmental transport, fate, and interactions of PFAS released into natural waters. The dissertation research presented here has focused on several of these questions and knowledge gaps in a vast range of scales - from molecular interactions to global transport of PFAS - all addressing the challenge of …

Ischemia-Induced Cytoskeletal And Nuclear Disruptions Drive Neuronal Death And Dysfunction: Insights Into The Connection Between Stroke And Dementia From In Vitro And In Vivo Models Of Stroke, Emily Potts

Open Access Dissertations

Stroke and Alzheimer’s disease and related dementias (ADRD) represent two of the leading causes of neurological disability worldwide, and their prevalence is expected to rise as the global population ages. Although stroke is traditionally viewed as an acute vascular event, a growing body of evidence suggests that transient ischemic injury can trigger lasting cellular disturbances that increase neuronal vulnerability to later neurodegeneration. Understanding how ischemic stress alters neuronal structure and function, and how these changes may overlap with pathways implicated in ADRD, is an emerging focus for stroke and neurodegenerative researchers. This dissertation addresses these questions through an integrated combination …

Resilience And Stress: Trauma, Grit, Resilience And Perceived Organizational Support In First Responders, Paige Gallas Parker

Theses and Dissertations

First responders comprise an underserved and under-researched population, despite consensus that their work involves exposure to potentially traumatic events. Inconsistent definitions of “first responder” and unclear prevalence rates of posttraumatic stress symptoms (PTSS) limit efforts to assess and promote resilience. This study examined the relationships between grit, resilience, perceived organizational support, and trauma symptoms in a sample of 234 first responders (69% firefighters, 29% lifeguards) employed by a large West Coast fire department. Measures included a demographics questionnaire, the Professional Exposure to Traumatic Events (PETE), the Posttraumatic Stress Disorder Checklist (PCL-5), the Connor-Davidson Resilience Scale (CD-RISC-10), the Short Grit Scale …

I Hate Self-Care: A Criminal Defense Lawyer’S Lament, Abbe Smith

Georgetown Law Faculty Publications and Other Works

Don’t get me wrong—I think people should take care of themselves. They should eat well, exercise regularly, and get a good night’s sleep. They should spend time with friends and family. They should have hobbies and interests. With any luck, they should find true love. But in the past decade or two, and especially since the COVID pandemic, there has been a disturbing turn inward. I’m talking about the “self-care” craze, which has become its own pandemic, or at least epidemic.

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In this Essay, I share my concerns about what I regard to be an excessive focus on self-care …

Recontextualizing Engagement With Data Visualizations In The Context Of The Socio-Ecological, Eva Thanheiser, Laurie Rubel, Beth Herbel-Eisenmann, Courtney Koestler

Mathematics and Statistics Faculty Publications and Presentations

We explore how data visualizations (DVs) are representational tools that can be used to narrate certain aspects of a context but silence others. Using multiple DVs allows for contrasting the DVs and likely provides opportunities for critical reading and exploring the entanglement of political and ecological dimensions of an issue. We start by integrating two sets of practices, Notice, Wonder, Feel, Act and Reimagine (NW-FAR) (Kahn, et al., 2022) and critical graph reading, Framing, Formatting, Narrating (FFN) (Rubel, et al., 2021) towards taking a socio-political stance and supporting students to read data visualizations and develop critical data literacy. We look …

War Crime Or Ecocide? Ukraine’S Prosecution Of Environmental Crimes Committed By Russian Forces, Michael J. Kelly

Emory International Law Review

No abstract provided.

Physicists As Environmental Experts, Rachel Rothschild

Articles

The question of which scientists are qualified to provide expert guidance in legal controversies is a perennial debate among scholars, judges, and lawyers. Scientists who participate in legal disputes can achieve enormous power and influence, not only over the case at hand but over long-term developments in legal doctrine. While these issues arise in many areas of the law, environmental litigation has been a particularly active site of contestations over epistemic authority. Courts have frequently relied on scientists to understand whether the government is justified in regulating pollution and who may be liable for environmental and public health harms.

This …

The Transnationalisation Of Civil Society In East Asia’S War Redress Movement, Timothy Webster

Faculty Scholarship

Transnational human rights litigation is commonly associated with developments in Europe and the Americas during the 1990s. But Asian actors have used legal mobilisation to hold corporate actors to account since at least the 1970s. This chapter charts the first usages of transnational litigation in East Asia’s Word War II redress movement, akin to the Holocaust Restitution movement of the West. Korean and Chinese forced labourers liaised with Japanese attorneys, activists and academics to press compensation claims against Japanese corporations for wartime human rights abuses in Tokyo. Legal mobilisation did not succeed in the traditional sense. Yet, the formation of …

Creative Energies: Unearthing The Role Of Romantic Ecocriticism, Nicole Marie Chambers-Stahl

Graduate Theses, Dissertations, and Problem Reports (ETD)

The literary field of ecocriticism has transcended the boundaries of Academia: excited to connect to their physical environments, many of these scholars are focusing on genres like place-based writing, rhetoric of energy policy, and representations of the Earth in film and media. Interdisciplinary by nature, ecocriticism has demonstrated clear potential in its ability to intersect with concentrations like the history of science, animal studies, and environmental justice.

However, as the language around global crises is heating up —“Today it is scientists, not prophets,” writes Tobias Menely in “‘The Present Obfuscation,’” “who speak the language of apocalypse” (478)—ecocritical scholarship is at …

The People Of The North: Influencer Histories And Miniaturization In Eleventh-Century Italy, Evan Anthony Simonetti

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Norman invasion of Italy in the eleventh century was a process that required political support and legitimacy for its leaders, the Hauteville dynasty. The members of this dynasty either commissioned or financed three individuals as they wrote three respective histories of the Norman conquest in order to accomplish this legitimation. In these sources, each author took inspiration from the classic works of history and poetry of the Greek and Roman world and applied symbolism and direction from their understanding of medieval Christian theology. In addition, these works catalogued examples of events, people, places, animals, and behavior as exotic objects …

Behavioral Effects Of Prenatal Ecig Aerosol Exposure On Sprague-Dawley Rats, Erin Elizabeth Wylie

Graduate Theses, Dissertations, and Problem Reports (ETD)

Maternal electronic cigarette (ECIG) use during pregnancy raises concerns about potential risks to offspring, yet its behavioral effects remain unclear. The present studies were designed to investigate how prenatal exposure to ECIG aerosols, with and without nicotine, influences the behavior of Sprague-Dawley rat offspring. Dams were exposed to aerosols containing base liquid alone, aerosols containing base liquid with 18 mg/ml nicotine, or filtered air (control) throughout gestation. Following postnatal day 65, male offspring from 17 litters completed lever-press acquisition (Experiment 1), sustained-attending (Experiment 2), and nicotine self-administration (Experiment 3) tasks. One-way analyses of variance (ANOVAs) were used to compare task …

Motivation And Well-Being: A Study Of Wvu Extension Volunteers, Amber Renae Goff

Graduate Theses, Dissertations, and Problem Reports (ETD)

Volunteers are the heart of the land-grant outreach model. They bring education and resources to communities across West Virginia. Volunteers have been relied upon in many aspects of Extension programming and current budget conditions have reduced the level of staffing within WVU Extension. There may be an increased demand for volunteers to help with programming. The purpose of this study was to investigate the relationship between motivation and the perceived level of well-being within the WVU Extension volunteer programs. The study yielded 464 responses from a descriptive survey. Based on the results, WVU Extension volunteers are motivated based on their …

New Treaty Law On Autonomous Weapons? An Opportunity To Reframe The Discourse, Laurie R. Blank

Case Western Reserve Journal of International Law

Calls for a new treaty for autonomous weapons—or for any other new technology—stem from a concern at the most basic level: the concern that LOAC’s existing treaties are not sufficient to fulfill their core purposes of protecting civilians and other vulnerable persons and regulating the conduct of hostilities. Could treaties drafted in 1949—when air power was new and space a distant dream, when the first operational computer ran its first program and navigation relied on the compass and sextant—be sufficient for the complexities and challenges of the electromagnetic spectrum, artificial intelligence, quantum mechanics, machine learning, cyber, anti-satellite weapons, and other …

Japanese Incarceration Memorial As Trauma Portfolio Play, A. J. Faas, Alyssa Singh, Cibella Gamma

Faculty Research, Scholarly, and Creative Activity

In collaboration with the Japanese American Museum of San José, California, we examined their exhibit of WWII-era incarceration of Japanese Americans to understand how the presentation of different positionalities (e.g., Japanese/American, loyal/disloyal) engage with and contest the terms of incarceration and internal politics within the Japanese American community. In our analysis, we focus on the reproduction and contestation of particular narratives of power and identity and treat the memorial exhibit as a variety of community-based “trauma portfolio” that unsettles state bureaucratic constructions of suffering and (in)justice. We conclude by identifying transformative possibilities for engaging with the different positionalities of incarcerated …

Unravelling The Ecological Trade-Offs In Behavioural And Physiological Sexual Traits, Alicia Eveson

School of Biological and Marine Sciences Theses

Animals experience temporally and spatially heterogeneous environments throughout their lives. Therefore, individuals that are able to plastically adjust their behaviour to the current environment, are able to maximise their fitness. These behavioural adjustments are particularly important where there are trade-offs between investment in different life-history traits. Trade-offs between reproduction and survival have been widely documented, in addition to a body of evidence for trade-offs between mating related traits. How an individual adjusts their mating behaviour in response to their social and biotic environments are important aspects of selection. Changes in the social environment, including sex ratio or population density changes, …

Development Of Welfare Assessment Strategies For Indonesian Zoos, Yonathan Yonathan

School of Biological and Marine Sciences Theses

Animal welfare assessment is a core element of zoo management, helping zoos achieve positive welfare state for their animals. Welfare should be assessed regularly to evaluate, monitor, and improve the standards of care. The research on welfare assessment and its development process increased after the World Association of Zoos and Aquariums (WAZA) launched the 2023 Animal Welfare Goals, which include mandatory welfare assessment process for national and regional zoo associations. In Indonesia, many zoos don’t have their own welfare assessment and find it difficult to adapt generic tools due to variation in husbandry, resources, and facilities. This project aims to …

How Do Human-Induced Environmental Stressors Shape The Distribution, Physiology, And Behaviour Of The Lemur Leaf Frog?, Benjamin Hough

School of Biological and Marine Sciences Theses

The Lemur leaf frog (Agalychnis lemur) is a critically endangered species of anuran whose survival is increasingly threatened by human-induced environmental stressors, such as habitat loss, fragmentation, and climate change. This study investigates how those stressors shape the physiology, distribution, and behaviour of the species through combinations of physiological and distributional modelling and a behavioural trial. The study uses a novel approach into understanding how future risk posed by climate change could impact Lemur leaf frogs. By using field spatial data combined with physiological mechanistic modelling, the study is able to predict how Lemur leaf frogs body temperature and geographical …

Effects Of Host-Derived Probiotics On The Growth Performance And Health Of Tilapia And Carp, Sherilyn Abarra

School of Biological and Marine Sciences Theses

To address the need for well-characterised probiotic strains for tilapia and carp aquaculture, this study investigated the isolation, characterisation, and application of host-derived candidate probiotics from Nile tilapia (Oreochromis niloticus) and mirror carp (Cyprinus carpio), and their influence on growth, feed utilisation, intestinal integrity and microbiome, and mucosal health of the host.A total of 263 intestinal bacterial isolates were screened in vitro for antagonism against Aeromonas hydrophila and Streptococcus iniae. The top 31 isolates with inhibitory effects underwent screening against three further fish pathogens and were assessed for haemolytic activity and extracellular enzyme production in …

Evaluating The Efficacy Of Brewers’ Yeast-Derived Functional Feed Additives In Mitigating Soybean Meal-Induced Enteritis In Atlantic Salmon, Taofik Adeiza Momoh

School of Biological and Marine Sciences Theses

Aquaculture continues to expand as a vital contributor to global food security, yet this growth introduces new challenges including the need to replace fishmeal with plant-based ingredients without compromising intestinal health. In Atlantic salmon aquaculture, one of the main constraints to plant protein inclusion is soybean meal-induced enteritis (SBMIE), a diet-related inflammatory condition that impairs mucosal function. Meanwhile, the use of functional feed additives such as those derived from brewers’ yeast (Saccharomyces cerevisiae) have emerged as a promising strategy to mitigate such diet-induced pathologies and support immune regulation. This thesis investigates the efficacy of structurally distinct brewers’ yeast-derived additives, including …

Considering Behaviour In Genetic Sampling – A Case Study With Grey Seals, Kathryn Wiltshire

School of Biological and Marine Sciences Theses

Genetic variations are increasingly linked to intra-specific behavioural variations. Advancing our knowledge of behavioural genetics could make screening populations for genetic polymorphisms associated with behavioural variations possible. Genetic-behaviour links have been increasingly discovered in terrestrial mammals, but there are few comparable studies in marine mammals. Developing efficient and cost-effective genetic sampling techniques is essential to allow more studies on behavioural genetics in lesser researched marine mammals. This study explores the potential of a sampling technique, still in its infancy in marine mammal studies, that has potential to cause minimal stress to the animals. Buccal swabs were tested in a group …

An Assessment Of The Dietary Bioavailability Of Tio2 And Inorganically Carbon-Based Nanomaterials In Rainbow Trout, Using The Ex Vivo Gut Sac Technique And A In Chemico Digestibility Assay, Craig Mchardy

School of Biological and Marine Sciences Theses

Abstract. Craig McHardyAn assessment of the dietary bioavailability of TiO2 and inorganically carbon-based nanomaterials in rainbow trout, using the ex vivo gut sac technique and a in chemico digestibility assay.Carbon based engineered nanomaterials (ENMs) are an emerging contaminant within modern society, as such their environmental risk assessment is of high importance. Testing for their persistence, toxicity and bioaccumulation potential is important for regulatory bodies to fully understand the hazard posed. To date, data on the bioaccumulation potential of these ENMs is lacking, especially within fish. A tiered approach to bioaccumulation testing has been posed in which precursory tests such as …

Impact Of Dietary Functional Yeast Additives On Growth Performance And Health Of Selected Key Aquaculture Species, Sheu Odu-Onikosi

School of Biological and Marine Sciences Theses

The aquaculture industry has witnessed remarkable growth in recent decades underscoring its crucial role in global food security. However, this rapid expansion brings challenges, including the need to meet growing fish demand while minimising environmental impacts and managing disease prevalence. Functional feed additives (FFAs) have emerged as sustainable solutions to enhance fish health and performance. Among these, yeast-derived additives have garnered significant attention for their nutritional benefits and proven ability to promote growth and strengthen immune responses in fish.This study evaluates the effects of dietary brewer's yeast-derived additives on fish using a range of in-depth analyses, such as growth performance, …

Dynamically Scaling Biomimetic Robots Through Parallel Viscoelastic Actuators, Foster Olaf Holmquist

Graduate Theses, Dissertations, and Problem Reports (ETD)

Robots provide a unique proving ground for testing scientists’ understanding of neuromuscular systems. Synergistically, mimicking biological control laws and mechanics could offer robotics the robust and adaptive locomotion of animals. Previous work has utilized the wealth of research on insect biomechanics to develop scaled robotic models but doing so presented a problem: while these robots’ larger scale has simplified manufacturing, the scale has also shifted its mechanics from those of the modeled organisms. While animals walk, forces are generated that describe their mechanics and influence motor control. The musculoskeletal structure and stretch of muscles result in viscous and elastic forces, …

The Effect Of Cerebellar Feedback On The Spatial Processing Of Conspecific Signals In The Electrosensory System, Dakota Ray Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Animals have evolved sensory systems to help decipher important environmental signals that are vital for their survival. Feedback pathways are necessary to allow these signals to stand out in a noisy background, enabling the animal to focus on them more effectively. The electrosensory system of Apteronotus leptorhynchus allows the fish to sense the modulations caused by other conspecifics to allow for proper responses during social interactions. Electroreceptors detect these EODs, and afferent nerves project these signals to the ELL, where electrosensory information is projected to other parts of the brain. Cerebellar feedback to the ELL allows the suppression of lower …

Clinical Criteria For Limbic-Predominant Age-Related Tdp-43 Encephalopathy, David A. Wolk, Peter T. Nelson, Liana Apostolova, Konstantinos Arfanakis, Patricia A. Boyle, Cynthia M. Carlsson, Nick Corriveau-Lecavalier, Penny Dacks, Bradford C. Dickerson, Kimiko Domoto-Reilly, Brittany N. Dugger, Rebecca Edelmayer, David W. Fardo, Michel J. Grothe, Timothy J. Hohman, David J. Irwin, Gregory A. Jicha, David T. Jones, Claudia H. Kawas, Edward B. Lee, Karen Lincoln, Gladys E. Maestre, Elizabeth C. Mormino, Chiadi U. Onyike, Ronald C. Petersen, Gil D. Rabinovici, Rosa Rademakers, Rema Raman

Biostatistics Faculty Publications

Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course. With the emergence of anti-amyloid therapeutics, discrimination of LATE-NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co-pathology with LATE-NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE-NC. We propose criteria for clinical diagnosis of …

A Myostatin Inhibitory Antibody Combined With Insulin, Partially Rescues The Musculoskeletal Phenotype Of Female Insulin-Deficient Diabetic Mice, R. Clay Bunn, Reuben Adatorwovor, Philip D. Ray, Alexander R. Keeble, Christopher S. Fry, Sasidhar Uppuganti, Jeffry S. Nyman, John L. Fowlkes, Evangelia Kalaitzoglou

Biostatistics Faculty Publications

Introduction: Type 1 diabetes is associated with deficits in both skeletal muscle and bone. Inhibition of myostatin, a negative regulator of muscle mass, was explored as a druggable target to improve the musculoskeletal phenotype associated with insulin-deficient diabetes in female mice. Methods: We investigated whether administration of an inhibitory myostatin antibody (MyoAb) in streptozotocin-induced diabetes in female mice is protective for skeletal muscle and bone. DBA/2J female mice were injected with low-dose streptozotocin or with citrate buffer (vehicle). Subsequently, mice were implanted with insulin-containing or vehicle pellets, with groups being randomized to myostatin or control antibody for 8 weeks. At …

The Inevitable Rise And Liberation Of Bipoc Community At Cal Poly Humboldt: A Historical Storytelling Timeline, Fernando Paz

Humboldt Journal of Social Relations

"The Historical Storytelling Timeline (HST) emerged as a central initiative in Cal Poly Humboldt's efforts to support and inform the Institutional Anti-Racism Call to Action Plan (IARCAP). Guided by the Office of Diversity, Equity, and Inclusion (ODEI), the HST not only chronicles the university's history of activism but also digitizes these efforts to ensure accessibility for future generations. This timeline is a commitment to honoring past struggles and successes..."

Intergenerational Arts In The Classroom: A Win-Win, Audrey Klunenberg

Graduate Research Papers

This paper suggests that intergenerational arts programs, particularly those conducted in public schools, can help participants build empathy, a sense of community and belonging. Evidence of these changes was collected through informal observations during three intergenerational art classes in a first grade classroom, as well as through discussions with participants before and after their participation in the intergenerational arts programming. Empathy and community can be built through carefully planned collaborative art-making opportunities and the effect can be evidenced in the forming of relationships, the absence of behavioral problems, and the building of the facilitator’s personal network. The paper concludes that …