Digital Commons Network^™

Multi-Locas Gwas Mapping And Candidate Gene Analysis Of Anticancer Peptide Lunasin In Soybean (Glycine Max L. Merr), Rikki Locklear, Jennifer Kusumah, Layla Rashad, Felicia Lugaro, Sonia Viera, Nathan Kipyego, Faith Kipkosgei, Daisy Jerop, Shirley Jacquet, Mythy Addelmajid Kassem, Jiazheng Yuan, Elvira De Mejia, Rouf Mian

Biological Sciences Faculty Publications

Soybean (Glycine max) peptide lunasin exhibits significant cancer-preventive, antioxidant, and hypocholesterolemic effects. This study aimed to identify quantitative trait nucleotides (QTNs) associated with lunasin content and to annotate the candidate genes in the soybean genome. The mapping panel of 144 accessions was gathered from the USDA Soybean Germplasm Collection, encompassing diverse geographical origins and genetic backgrounds, and was genotyped using SoySNP50K iSelect Beadchips. The lunasin content in soybean seeds was measured using the enzyme-linked immunosorbent assay (ELISA) method, with lipid-adjusted soybean flour prepared from seeds obtained from the Germplasm Resource Information Network (GRIN) of USDA-ARS in 2003 and …

Codec-M: The Multi-Lingual Manosphere Subcorpus Of The Corpus Of Digital Extremism And Conspiracies, Rachel Mccullough, Daniel Drylie, Mindl Barta, Cass Dykeman, Daniel Smith

English Faculty Publications

In 2023, the U.S. Surgeon General warned the public of the current “loneliness epidemic” and its potential consequences on physical and mental health. One possible consequence of this epidemic is the growth of a movement defined by loneliness and isolation: the incel (“involuntary celibate”) movement. This warning presents a worrying glimpse at the future, as the incel movement, along with other parts of the manosphere, is one that espouses violently misogynist rhetoric which is intrinsically linked to right-wing extremism. While linguistic studies have been conducted on the speech of incels and other constituent movements of the manosphere, few of these …

Deciphering The Chemistry Of Condensed Aromatic "Black" Carbon And Nitrogen In Amazonian Anthrosols, João Vitor Dos Santos, Aleksandar I. Goranov, Laís G. Fregolente, Marcia C. Bisinoti, Zhenhuan Sun, Klaus Schmidt-Rohr, Patrick G. Hatcher

Chemistry & Biochemistry Faculty Publications

Amazonian anthrosols are renowned for their high fertility and dark color, properties primarily attributed to the abundance of condensed aromatic carbon (ConAC) in the soil organic matter. ConAC, commonly referred to as black carbon, play a key role in the stability and nutrient retention of these soils. However, the processes governing the formation of ConAC and its transformation into oxygenated derivatives remain poorly understood. In this study, we used multiple analytical platforms to investigate the chemistry of ConAC-rich humic acids (HA) extracted from Terra Mulata de Indio, a type of Amazonian anthrosol. The results reveal that ConAC are predominantly …

Assemblage Structure Of Large Carnivorous Coral Reef Fishes At Shallow And Mesophotic Depths In Two Of The Largest And Most Isolated Marine Protected Areas In The Philippines, Rene A. Abesamis, Mikaela L. Salvador, Ryan Murray, Kymry Delijero, Segundo F. Conales, Jean T. Utzurrum, Christopher E. Bird, David T. Gauthier

Biological Sciences Faculty Publications

Overfishing remains a threat to coral reef fishes globally, with large carnivores often the most vulnerable. Marine protected areas (MPAs) can restore fish populations and biodiversity, but their impact has been understudied in mesophotic coral ecosystems (MCEs – extensions of shallow reefs from 30 to 150 m). We analyzed baited remote underwater videos recorded in 2016 to investigate the assemblage structure of large carnivorous fishes at shallow (4–12 m) and mesophotic (45–96 m) depths in two of the largest and most isolated MPAs in the Philippines: Tubbataha Reefs Natural Park (TRNP), a fully no-take MPA enacted in 1988; and Cagayancillo, …

Building Heat-Resilient Caribbean Reefs: Integrating Thermal Thresholds And Coral Colonies Selection In Restoration, Macarena Blanco Pimentel, Johanna Calle-Triviño, Daniel J. Barshis, Sancia E. T. Van Der Meij, Megan K. Morikawa

Biological Sciences Faculty Publications

Caribbean reefs face increasingly frequent and intense bleaching events, adding to the numerous other threats impacting these ecosystems. Addressing these challenges requires global action to reduce climate drivers, along with local efforts like reef restoration. Active restoration using thermotolerant coral colonies offers a potential strategy to alleviate these impacts; however, gaps remain in identifying context-specific temperature thresholds to guide colony selection and standardize thermotolerance assessment methods. This study addressed these gaps in two phases. First, by determining practical thresholds to differentiate species responses to heat stress; and second, by developing a framework to identify and prioritize resilient colonies for restoration. …

Emerging Nanotechnology Approaches For Blood Disorders: A Comprehensive Review Of Nano-Hematinics And Plant-Based Nanomedicines, Hassan Abdulsalam Adewuyi, Khairat Shamsudeen, Fatima Mahmoud Muhammad, Adeola Kolawole Victor, Sakariyau Adio Waheed, Adepeju Matilda Adekoya, Kashim Ibrahim Muhammad, Blessing Temitayo Longe, Abdulgaffar Abdulquddus

Chemistry & Biochemistry Faculty Publications

Background: Disorders affecting blood components, such as anemia, coagulopathies, and hematologic malignancies, continue to pose significant global health burdens. Traditional therapies often fall short due to adverse effects, limited bioavailability, and insufficient targeting of disease sites.

Objective: This review synthesizes current advances in nano-hematinics and plant-based nanomedicines (phyto-nanomedicines) as innovative strategies for managing blood-related conditions. These nanoscale interventions are designed to enhance therapeutic precision, bioactivity, and safety.

Methods: A systematic review was conducted using major scientific databases including PubMed, Scopus, Web of Science, and ScienceDirect. Search terms were carefully selected to retrieve literature published between 2015 and 2024 that discussed …

Robust Quantification Of Cortical Hemodynamic Response To Tactile Stimulation: A Comprehensive Fnirs Methodology To Mitigate Physiological Confounds, Mohsen Hozan

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation establishes a quantitative framework for studying somatosensory processing using functional Near-Infrared Spectroscopy (fNIRS), with a focus on applications in neurorehabilitation. The central aim is to investigate how the brain's hemodynamic response is modulated by the velocity of patterned tactile stimulation. While fNIRS is a promising neuroimaging tool, its data quality is often compromised by physiological noise and motion artifacts, challenging the reliability of its findings and hindering the development of effective, quantifiable neurotherapeutics.

Two preliminary investigations informed the final experimental design. The first pilot study confirmed that pneumotactile stimulation of the hand, during both passive (somatosensory) and active …

Metamorphosis And Fairy Tale Tropes In Christa Wolf’S Patterns Of Childhood, B. E. Lara

Master's Theses and Doctoral Dissertations

This study is a sociohistorical analysis of East German writer Christa Wolf’s use of fairy tale tropes in her novel Patterns of Childhood, first published in German in 1976 in East Germany as Kindheitsmuster. Wolf uses fairy tale tropes to explore themes that she could not write about openly under East German censorship, which prohibited East German authors from exposing their culpability for prior acts committed under the Nazi Regime. Furthermore, Wolf introduces metamorphosis to explore the intrinsic evil and subsequent guilt of her child protagonist, and she uses the child’s capacity for evil to illustrate the German people’s similar …

Algorithms In Finance: Balancing First Amendment Protections And Regulation, Yusraa Tadj

Fordham Journal of Corporate & Financial Law

As algorithms become a function of decision-making in the financial sector, policymakers, the judiciary, and academics grapple with regulatory questions. With the increased reliance on algorithms in finance, the Securities and Exchange Commission (SEC) proposed a rule to mitigate potential conflicts of interest that can arise out of financial firms using algorithms. Algorithm users, including financial firms, are finding novel ways to protect algorithm use, such as by offering them First Amendment protections.

This Note considers to what extent algorithms can be considered protected speech amidst the complexity of algorithms and relationship within the financial sector. The Note argues that …

Nicorandil Treatment Improves Survival And Spatial Learning In Aged Granulin Knockout Mice, Dana M. Niedowicz, Wang-Xia Wang, Paresh Prajapati, Yu Zhong, Shuling X. Fister, Colin B. Rogers, Pradoldej Sompol, David K. Powell, Indumati Patel, Christopher M. Norris, Kathryn E. Saatman, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Mutations in the human granulin (GRN) gene are associated with multiple diseases, including dementia disorders such as frontotemporal dementia (FTD) and limbic-predominant age-related TDP-43 encephalopathy (LATE). We studied a Grn knockout (Grn-KO) mouse model in order to evaluate a potential therapeutic strategy for these diseases using nicorandil, a commercially available agonist for the ABCC9/Abcc9-encoded regulatory subunit of the “K⁺ATP” channel that is well-tolerated in humans. Aged (13 months) Grn-KO and wild-type (WT) mice were treated as controls or with nicorandil (15 mg/kg/day) in drinking water for 7 months, then tested for neurobehavioral …

Disrupted Calcium Dynamics In Reactive Astrocytes Occur With End Feet–Arteriole Decoupling In An Amyloid Mouse Model Of Alzheimer’S Disease, Blaine Weiss, John C. Gant, Ruei-Lung Lin, Jenna L. Gollihue, Colin B. Rogers, Susan D. Kraner, Edmund B. Rucker, Yuriko Katsumata, Yang Jiang, Peter T. Nelson, Donna M. Wilcock, Pradoldej Sompol, Olivier Thibault, Christopher M. Norris

Sanders-Brown Center on Aging Faculty Publications

While cerebrovascular dysfunction and reactive astrocytosis are extensively characterized hallmarks of Alzheimer's disease (AD) and related dementias, the dynamic relationship between reactive astrocytes and cerebral vessels remains poorly understood. Here, we used jGCaMP8f and two-photon microscopy to investigate calcium signaling in multiple astrocyte subcompartments, concurrent with changes in cerebral arteriole activity, in fully awake 7- to 8-month-old male and female 5xFAD mice, a model for AD-like pathology, and wild-type (WT) littermates. In the absence of movement, spontaneous calcium transients in barrel cortex occurred more frequently in astrocyte somata, processes, and perivascular regions of 5xFAD mice. However, evoked arteriole dilations (in …

Gender Disparity In Social Security, Kathryn L. Moore

Law Faculty Scholarly Articles

Facially neutral, the U.S. Social Security system structurally discriminates against women because it prefers those who successfully fulfill the traditional male breadwinner role rather than the traditional female caregiving role. Overall, women receive lower worker benefits, are much more likely to claim spouse and surviving spouse benefits, and are more dependent on Social Security for their retirement benefits than are men.

This Article assesses Social Security’s disparate treatment of women and how Social Security might be reformed to enhance benefits for women. It begins by providing a broad overview of Social Security benefits. It then discusses how women and couples …

The Migration Of Abolition Theory, Matthew Boaz

Law Faculty Scholarly Articles

This Article considers whether and how theories of abolition developed by criminal law scholars are transferrable to the realm of immigration enforcement. A key question is how abolitionist principles might be employed in support of critiques of the United States’ immigration regulatory regime in the same way that these principles have been deployed in denouncing racialized policing and an injurious, industrialized prison system.

This Article makes two contributions: First, it identifies and illuminates a methodology adopted by critical and decarceral criminal law scholars: (i) denouncing the harms of a structural system, (ii) identifying the normative justification(s) for this system, and …

Knee Health Is A Major Determinant Of Mobility Across The Healthspan, Brandon M. Peoples, Kenneth Harrison, Michael A. Samaan, Christopher B. Mobley, David T. Redden, Jaimie A. Roper

Kinesiology and Health Promotion Faculty Publications

Knee health constitutes a pivotal determinant of locomotor function and overall mobility throughout the healthspan. Impairments in knee function lead to a series of biomechanical and physiological alterations that pose substantial public health challenges and economic burdens worldwide. This review synthesizes evidence that delineates the complex and multifaceted relationship between knee health and mobility, emphasizing the interplay across various domains in adult populations. Knee health is conceptualized as a dynamic, interconnected system whereby structural integrity, neuromuscular mechanisms, biomechanical adaptations, and functional mobility are intricately interrelated through cascades of mechanistic processes operating across different temporal stages. A comprehensive understanding of these …

The Black Panther Party: From Militancy To Social Activism, De'andre Brown Jr.

History and Political Science | Senior Theses

This research project examines the ways in which the Black Panther Party (BPP) was negatively portrayed by the media and targeted by the government from the moment of the organization's inception in 1966. The BPP’s shift in rhetoric style from militancy to social activism is emphasized by examining the organization’s “survival” programs, such as the Free Breakfast Programs, Free Health Clinics, and Education Programs, and their impact on black communities around the country. Past scholarly opinions about the BPP were driven by a fear from white America toward the organization’s aggressive style of protest and social activism. The government looked …

Averting "Death By Powerpoint", Nora Xinyi Cai

ENGS 15.11: Design and Education

This lesson empowers students to design presentation slides that effectively communicate their ideas to unfamiliar audiences. The lesson emphasizes the key guiding principle for slide design, one message per slide, along with four steps to implement it. Students will develop the vocabulary to assess the quality of others' presentation slides and apply these four steps in creating their own. The lesson seeks to cultivate a dynamic, collaborative, and creative learning environment by design.

Systematic Review Of Immunohistochemistry Protocols, Arpitha Parthasarathy

Pitzer Senior Theses

Immunohistochemistry (IHC) is an essential technique in biological research that allows for the visualization and localization of proteins within tissue samples. This systematic review analyzes the most effective, efficient and reproducible protocols for IHC. It focuses on three critical steps: freezing, cryosectioning, and staining of skeletal muscle tissues in mice models. A total of 41, 44, and 48 articles on freezing, cryosectioning, and staining techniques, respectively, were analyzed, from reputable sources in biology like PubMed and Web of Science. Results showed the following. For freezing, the use of isopentane combined with liquid nitrogen appeared to be the best method, minimizing …

Crisis In The Current: A Proposed Study On The Impact Of Columbia River Basin Water Quality On Juvenile Chinook Salmon Survival, Olivia Buist-Thuillier

Pitzer Senior Theses

Salmon occupy a vital role in the ecosystem, economy, and indigenous culture of the Pacific Northwest of the United States, specifically within the Columbia River Basin. Of the five species of Pacific Salmon that live in the basin, Chinook salmon (Oncorhynchus tshawytscha) are the most widely commercially fished and are the largest. In recent years, Chinook Salmon populations have heavily declined from human influence. Rising temperatures from anthropogenic climate change, habitat destruction (dams, human presence), runoff from agricultural practices, and overfishing have all contributed to this decline. Because of their role as a keystone species and their cultural significance, there …

Space For The Departed: Burial, Land Scarcity, And Bone-Ash Apartments In China, Xinyi Wu

Pitzer Senior Theses

The rise of bone ash apartments in China reflects a layered response to urban land scarcity, shifting funeral policies, and real estate speculation. As the state mandates cremation and restricts private cemetery development, traditional burial customs are increasingly reshaped by spatial limitations, economic pressures, and political regulation.

For some families, bone ash apartments function as modern ancestral halls—domestic spaces for remembrance and ritual continuity. For others, they represent a pragmatic investment strategy, offering long-term storage of ashes within assets that retain market value.

This thesis examines how urban planning, state funeral policy, real estate dynamics, and the disintegration of neighborhood …

Beyond The Bin: Transforming Relationships With Waste Through A Collaborative Inquiry-Based Environmental Education Curriculum, Kaylee V. Morris

Pitzer Senior Theses

This thesis presents Beyond the Bin, a collaborative inquiry-based environmental education curriculum designed to transform how young learners understand and interact with waste. Motivated by the limitations of current downstream waste education—focused primarily on consumer behavior and individual disposal practices—this project argues for an upstream approach that identifies the underlying cause of these prevalent systems of disposability. Grounded in environmental education theory, affective learning, and ecological literacy, the curriculum encourages students to rethink waste as a material with creative potential rather than something to discard. Through creative engagement, experiential learning, and community-based initiatives, the curriculum fosters collaboration between students, teachers, …

The Solar Maya: Resilience And Strength In The Face Of Climate Change, Anna Frances Paradise

Pitzer Senior Theses

The solar maya of Yucatán, Mexico is an example of a sustainable agroecosystem that holds the potential to embed resilience in the livelihoods of those who utilize it. However, this traditional and indigenous system of agriculture is threatened by the immense forces of urbanization and modernization imposed on the area. I conducted research that included 14 different in-person and online interviews of academic and local personnel in Mérida and in nearby Yucatecan municipalities as well as visited seven different solares mayas, documenting my findings through audio recordings and photographs. With this collection of qualitative data, I found trends in the …

Farming As Life: Reframing Smallholder Farming As A Site Of Self-Sufficiency And Cultural Heritage In Botswana, Natasha Yen

Pitzer Senior Theses

Dominant neoliberal frameworks often frame smallholder farming through a deficiency lens, reducing it to metrics of productivity, efficiency, and profitability. These perspectives overlook the deeper material, cultural, and social significance that farming holds in the lives of smallholder farmers. In Botswana—where approximately 70% of the rural population engages in smallholder farming—farming remains a vital part of everyday life, yet few studies adopt a culturalist or holistic lens to examine its meaning. To center smallholder farmers’ lived experiences and perspectives, this study is based on semi-structured interviews with ten smallholder farmers in southeast Botswana. Grounded in a culturalist framework and critical …

Public Land And Political Identity: Problematizing Open Space Preserves In Marin County, California, Samantha Gottsegen

Pitzer Senior Theses

This thesis is an interdisciplinary exploration of the role of protected natural areas—namely county-run open space preserves—in shaping political identity in Marin County, California. I critically examine the politicization of public lands and the sociorelational dynamics that emerge within local communities surrounding protected open space. I seek to deconstruct dominant understandings of landscape and nature as apolitical, neutral, or untouched, instead approaching public land as a site of ongoing meaning-making, identity formation, and power negotiation. I further place emphasis on the role of the state, through county governing bodies and affiliated organizations, in mediating access, constructing narratives of ownership, and …

Hope For A New Us/Earth Via E-Co-Aectivity And Jeong (정 情), Jea Sophia Oh

Philosophy Faculty Publications

In E-Co-Affectivity, Marjolein Oele explores the deep connectivity and relational entanglements of plants, animals, humans, and the soil as elemental components of a co-affective community. Her deconstructive reading of the Aristotelian conception of degrees of three souls, with such hierarchy of humans-animals-vegetables via what she calls categorical contamination,” is a brilliant example of how re-reading the western canon can cast important interpretive light upon contemporary ethico-political questions. Oele’s work shows how it is crucial to foreground (eco)feminist re-interpretations of the writings of major figures in the western philosophical traditions. It is reconstruction and construction of feminist hermeneutics so that it …

Between A Rock And A Wet Place: Analyzing Mangrove Expansion On Intertidal Oyster Reefs, Lindsay Dolan, Andre Wicks, Lina Souza, Jenna Hodgson, Gabriella Zigler, Ethan Gau, Meagan Pack, Antonia Ferguson, Gwyn Kirby, Mako Rosario, Lee Nguyen, Dwartney Wortham, Jack Budd, Michelle Ganuza, Abby Greene, Cori Mcwilliams, Dyllon Thompson, Emma Quade, Dani Andrews, Jessie Shaffer, Abigail Bond, Julia Murray

High Impact Practices Student Showcase Spring 2025

As global temperatures rise due to climate change, tropical mangroves have spread poleward and now impact many other ecosystems, including salt marshes and oyster reefs in central Florida. A recent study documented a 198% increase in mangrove numbers on intertidal reefs of the eastern oyster (Crassostrea virginica) since 1984 in the Indian River Lagoon (IRL). Our field research project had two goals. First, to collect 2025 data as part of a long-term study to understand the current dimensions, densities, and spatial distributions of red mangroves (Rhizophora mangle) on intertidal oyster reefs in Mosquito Lagoon (north IRL), and second, to compare …

Predicting Milk Quality With Machine Learning, Franco Vidal, Matthew Nighting-Henderson​

High Impact Practices Student Showcase Spring 2025

Milk is a critical component of diets around the world, offering essential nutrients such as protein, calcium, and vitamin B12. However, in many low-income and rural regions, milk quality is often compromised due to poor storage conditions, lack of pasteurization, and even intentional adulteration. Low-quality milk poses serious health risks, including bacterial infections, toxin exposure, and long-term organ damage. These challenges highlight the need for reliable, accessible methods to assess milk quality without relying on costly laboratory testing.

In this study, we propose a data-driven approach to predict milk quality using ordered logistic regression. The dataset used, sourced from Kaggle, …

Musical Analysis Of Chanting Melodies In The Teochew Chinese Yoga Tantra Ritual In Thailand, Rachan Sornchai, Narongchai Pidokrajt, Poonpit Amatyakul

Journal of Urban Culture Research

This study explores the musical elements of the Dharma Sankhita chants in the Mahayana Teochew Chinese Yoga Tantra ritual at Kak Hang Niam Huk Lim Monastery, Bangkok, Thailand. It examines the ritual’s background and musical analysis. Practiced by both Teochew and Cantonese Chinese, the ritual known in Teochew as “Bang Iem Kao” is a profound act of filial piety and ancestor veneration, rooted in the Eight Cardinal Virtues of Chinese ethics. The ceremony is held to dedicate merit to deceased ancestors and preserve cultural traditions. It can be performed at both family and community levels, encouraging intergenerational participation and solidarity. …

An Initial Report On The Search For The Missing Gamelan Heritage Of The Sumenep Palace, Madura, East Java-Indonesia, Aris Setiawan, Zulkarnain Mistortoify

Journal of Urban Culture Research

This research endeavors to locate the long-lost heirloom gamelan from the Sumenep Palace. Since the abolition of aristocratic status in 1883, the Sumenep Palace has lost political and economic legitimacy. To maintain the luxurious lifestyle of the aristocratic court, valuable items, including gamelans, were sold. The heirloom gamelans in the Sumenep Palace are believed to have been gifts from the Mataram Palace, often exchanged during various events, such as marriages. Employing an investigative ethnographic approach, this study gathered data through in-depth interviews with cultural practitioners, palace descendants, and private collectors; direct observation of remaining artifacts; and analysis of historical documents …

Exploring National Identity Through Modern Monumental And Decorative Tapestry Of Kazakhstan, Baurzhan Doszhanov, Ainash Nauryzbayeva, Yerbol Kairanov, Mukhamejan Suleimenov, Malik Mukanov

Journal of Urban Culture Research

In the context of technical and global transformations, art persists in articulating national identity. The aim of this study is to analyze in depth the art of monumental decorative tapestry in Kazakhstan, with a focus on its contribution to the search for a new paradigm and national identity in contemporary visual arts. Methods of analyzing and comparing artistic works of tapestry artists of contemporary Kazakhstan were used. This research analyses chosen works and their impact on the cultural environment, demonstrating that current monumental and decorative tapestries in Kazakhstan serve not merely as aesthetic objects but also actively contribute to the …

The Battle Spirit : The Cultural Essence Of Buddhist Temple Murals In Northeast Thailand, Ya-Liang Chang

Journal of Urban Culture Research

The murals found in Buddhist temples across Thailand play a significant role in the country's social fabric and are integral to the safeguarding efforts of Thailand's intangible cultural heritage. The research aims to explore the essence of murals in 24 Buddhist temples in Isan, delving into the principles guiding their creation. The author explores the intrinsic meanings embedded in these murals and deconstructs the cultural essence of Isan through a qualitative study. The investigation reveals the core essence of Isan's murals as the “battle spirit,” intricately woven across individual, societal, and national levels. Serving as conduits for Buddhist teachings on …