Digital Commons Network^™

Vitamin D Deficiency And Its Role In Pathologies Of Oxidative Stress: A Literature Review, Philippe Dentino, Johanna Mora, Li Zuo

School of Medicine Publications

Vitamin D (VD) is a key mineral providing critical modulation of reduction-oxidation homeostasis within biological systems. VD and the VD receptor coordinate essential cellular activities, including mitochondrial electron transport, respiration, antioxidation, gene regulation, and calcium transportation. Reactive oxygen species (ROS), a natural by-product of cellular metabolism, play a prominent role in the mechanisms of biological antioxidant systems and form the basis of antioxidant therapies. However, ROS may also perpetuate pathological processes when produced in excess secondary to inflammatory pathways. Aging processes within cells rely on this reduction-oxidation homeostasis. Thus, the interaction with VD, its receptor, mitochondria, and oxidative stress forms …

Isolation, Identification, And Antitumor Activities Of Glucosinolates And Isothiocyanates In Chinese Cabbage Seeds, Bei Zhou, Ying Liu, Xi Feng, Qian Liu, Salam A. Ibrahim, Wen Huang

Faculty Research, Scholarly, and Creative Activity

Isothiocyanates (ITCs), which are derivatives of glucosinolates (GSLs) from Brassica plants, have been investigated as anticancer agents. An extensively studied anticancer ITC is sulforaphane, which is found in low amounts in Chinese cabbage. We aim to investigate the types and content of GSLs (precursors of ITCs with anticancer activity) in Chinese cabbage seeds. GSLs from Chinese cabbage seeds were isolated and purified using acidic Al2O3 column chromatography and preparative HPLC. GSL and ITC profiles were further identified using UHPLC-Q-TOF-MS. The antitumor activities of ITC (produced by exogenous enzymatic hydrolysis of GSLs) were evaluated in vitro. Seventeen GSLs and seven ITCs …

Prenatal Diagnosis Of An Uncommon Form Of A Hypoplastic Left Heart Syndrome Variant., Anmol Goyal, Abigail Phillips, Kelsey Brattrud, Rita France, Maria Kiaffas

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Mitral valve dysplasia syndrome (MVDS) is a rare cardiac defect requiring accurate prenatal identification and appropriate counseling, delivery planning, and postnatal management.

CASE SUMMARY: A 39-year-old woman underwent fetal echocardiography at 34 weeks' gestation owing to cardiomegaly and hydrops. Biatrial enlargement, mild to moderate atrioventricular valve insufficiency, dysplastic mitral valve apparatus, biventricular dilation with systolic dysfunction, endocardial fibroelastosis, hypoplastic aortic outflow, and severely restrictive atrial septum were attributed to MVDS. The plan for critical (class IV) delivery was modified with premature onset of labor at 36 weeks' gestation, leading to urgent cesarean section. Emergent balloon atrial septostomy was performed …

Gastrointestinal Fistulas-What Gastroenterologists Need To Know In 2025, Monjur Ahmed

Division of Gastroenterology and Hepatology Faculty Papers

Gastrointestinal fistulas are increasingly being encountered in our clinical practice because of the increased burden of Crohn's disease, bariatric surgeries, interventional endoscopic procedures, nonsurgical trauma, and war and disaster zones worldwide. Presentation depends on the location and specific type of the fistula. Symptomatic ones can have a tremendous impact on social life and can cause dehydration, electrolyte imbalance, malnutrition, increased morbidity, and mortality. Different imaging studies and endoscopic procedures are done to establish the diagnosis. Treatment modalities to close the fistula depend on the underlying disease and the type of fistula. They include conservative treatment, medical therapy, endoscopic interventions, and …

Effects Of Light Wavelength On Broiler Performance, Blood Cell Profiles, Stress Levels, And Tibiotarsi Morphology, Angela Perretti, Victor J. Oyeniran, Jaelen M. Cherry, Rosemarry H. Whittle, Zachary Grider, Alexander H. Nelson, Seong W. Kang, Gisela F. Erf, Shawna L. Wiemer

Poultry Science Faculty Publications and Presentations

Lighting influences broiler production, health, and behavior. The objective of this study was to examine the effects of three light wavelengths (White [350-780 nm], Blue [450 nm], and Green [560 nm]) on broiler production, activity, fear, stress, blood cell profiles, and tibiotarsi (tibia) morphology. Day-of-hatch male broiler chicks (N = 600) were housed in pens (N = 12) with one lighting treatment for 42 days. Body weight and feed consumption were recorded on day (D) 0, 14, 28, and 42, and the feed conversion ratio was calculated. The Tonic Immobility test was used to assess the latency (seconds) to right …

Review Of Microgravity Biotechnology For Space Applications: The Anujiva Perspective, Saranya Ravva, Yukti Makkar, Abeneth Ramachandran, Sai Kiran Parre

Small Satellite Conference

Biomanufacturing in microgravity presents transformative opportunities for biotechnology beyond the limitations of terrestrial environments. Gravity-driven convection, sedimentation, and contamination risks often hinder biological productivity on Earth. In contrast, space-based conditions enhance protein crystallization, three-dimensional cell culture, and the production of novel biomaterials. This review synthesizes recent advancements in microgravity-enabled biotechnology, drawing from recent peer-reviewed literature and mission data.

We focus on the emerging field of autonomous bioreactor systems for space applications, emphasizing innovations in miniaturization, closed-loop environmental control, and real-time sensing. As a representative case study, we examine the AnuJIVA initiative, a CubeSat-based platform engineered for cultivating microorganisms such as …

The Shorthorn: May 15, 1956

The Shorthorn Newspaper Collection: 1950s

No abstract provided.

Snake Spirits, Fishermen And Water Birds On Lake Victoria: A Case Study Of Cultural Conservation In The Musambwa Islands, Uganda, And Prospects For Tourism To Improve Local Livelihoods, Joel T. Heinen, Henry Batenda

Journal of Ecological Anthropology

Abstract.

Using a combination of site visits, document reviews, focus group and key informant surveys of fishermen, we explore the cultural beliefs, taboos and norms that protect Musambwa Islands, Uganda. The islands form part of a large protected wetland with nesting habitat for thousands of water birds and a large population of highly-venomous forest cobras that coexist in and around fishermen dwellings. There are strong taboos against cutting trees, allowing women on the island, and harming cobras. We present some of our ideas on how to improve the economic situation of fishermen through the promotion of nature-based and cultural tourism …

Moral And Ethical Nature In Confucian Liang-Zhi And Islamic Fitra: Comparative Perspectives On Innate Morality, Yanrong Shi

Comparative Philosophy

This article offers a comparative philosophical analysis of Confucian liang-zhi (innate moral knowledge) and Islamic fitra(primordial nature), focusing on their accounts of innate morality and moral epistemology. Drawing on classical Confucian sources—especially the praxis-oriented interpretation of Wang Yangming—and foundational Islamic texts and commentary, the study demonstrates that both traditions posit an inborn moral faculty grounding ethical universality and responsibility. Wang Yangming’s liang-zhi is conceived as an innate moral principle that, under the imperative of zhi (to actualize or extend), is continually activated through moral practice. In parallel, fitra is understood as a God-given orientation to truth, cultivated and safeguarded through …

Reassessing The Deontological Undercurrents In Mo Zi’S Ethical Thought, Nuno Miranda

Comparative Philosophy

This article reexamines Mo Zi’s ethical philosophy, challenging the dominant interpretation of Mohism as a purely consequentialist or proto-utilitarian system. While Mo Zi’s emphasis on social utility—such as material welfare, population growth, and aversion to warfare—aligns with outcome-oriented reasoning, I argue that his invocation of the will of Heaven introduces a deontological dimension. Heaven’s will serves not merely as a heuristic for maximizing benefits but as an absolute moral standard, demanding adherence to duties like universal love and non-aggression, irrespective of immediate practical gains. Through a close reading of the Mo-Zi corpus, this study reveals a hybrid ethical framework that …

Eshta’Ol: Faunal Remains From The Chalcolithic Period And Bronze Age, Edward F. Maher

Qadum: Journal of Excavation Reports from Israel

This article presents a zooarchaeological study of a small faunal assemblage recovered from Areas B, D and E at Eshta’ol, dating to the Late Chalcolithic period (Stratum IV), Early Bronze Age IB (Stratum III) and Intermediate Bronze Age (Stratum II). A total of 250 bone fragments were analyzed, with 86 identifiable specimens representing eight species, primarily from the EB IB stratum. The assemblage is dominated by domestic animals—especially caprines, cattle and pigs. Mortality profiles based on epiphyseal fusion and dental wear indicate a preference for secondary products—such as wool, milk and dung—over meat consumption. Small-scale farming and agricultural activity may …

Development Of Emerin Mrna Lipid Nanoparticles To Rescue Myogenic Differentiation., Nicholas Marano, Liza Elif Guner, Rachel S Riley, James M Holaska

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Emery-Dreifuss muscular dystrophy 1 (EDMD1) arises from mutations in EMD. Most EDMD1 patients lack detectable emerin expression. They experience symptoms such as skeletal muscle wasting, joint contractures, and cardiac conduction defects. Currently, physicians rely on treating patient symptoms without addressing the underlying cause-lack of functional emerin protein. Thus, there is a need for therapeutic approaches that restore emerin protein expression to improve patient outcomes. One way would be to deliver emerin mRNA or protein directly to affected tissues to restore tissue homeostasis. Here, we evaluated the utility of lipid nanoparticles (LNPs) to deliver emerin mRNA to diseased cells. LNPs …

Effect Of Whole-Food Plant-Based Diet On Ldl Cholesterol: A Scoping Literature Review, Joel Gregory Mueller

Nursing Capstones

Background: The whole-food, plant-based (WFPB) diet includes whole grains, whole plants, unrefined sugars, beans, and legumes. The diet excludes meat, dairy, and added fats. The diet has been popularized by documentaries .The diet claims to lower total and LDL cholesterol to a safe level as both a primary and secondary mode of prevention.

Purpose: Review existing studies to see whether the WFPB diet will lower LDL cholesterol in adult males over a 14 day or more duration.

Methods: A scoping literature review was completed of the University of North Dakota’s library system for keyword combinations. The returned 102 studies were …

Female Sexual Offenders: An Underrecognized, Underreported, And Underresearched Population, Chelsea H. Henry

Master of Arts in Human Services

This paper explored female sexual offenders and described how their crimes are underrecognized, underreported, and underresearched. Women commit part of all sexual crimes against children, although prevalence rates are hotly debated. Research demonstrates that female offenders are often their victims' mothers, caregivers, or other relatives. This societal role leads to difficulty in recognizing that this type of abuse exists. Media portrayals often cast female offenders in the role of victims themselves or cast the abuse in a positive light. Females are often the producers of online child sex abuse material, and more research is needed on this understudied topic as …

The Experiences Of Middle School Students In A Career And Character-Focused Curriculum: A Phenomenological Study, Don J. Hoover

ATU Theses and Dissertations 2021 - Present

THE EXPERIENCES OF MIDDLE SCHOOL STUDENTS IN A CAREER

AND CHARACTER-FOCUSED CURRICULUM:

A PHENOMENOLOGICAL STUDY

Don Jason Hoover

The purpose of this qualitative phenomenological study was to explore the lived experiences of former middle school students who participated in a two-year character development, career readiness, and leadership program implemented in a public junior high school. Guided by Bandura’s social learning theory, the study focused on how students experienced and internalized the program’s components, which included leadership training, social learning activities, and college and career readiness preparation. The research was conducted using semistructured interviews with 10 participants who had completed the …

Digital Trading Platform Selection Under Neutrosophic Numbers And Multi-Criteria Decision-Making Methodology: An Illustrative Example, Eman Sayed, Karam M. Sallam, Ibrahim Alrashdi

Neutrosophic Systems with Applications

Uncertainty, vagueness, and incomplete information are pervasive in real-world decision-making scenarios, particularly in multi-criteria decision-making (MCDM) contexts involving expert judgments. To address these challenges, this study introduces a comprehensive decision-making framework that integrates Triangular Neutrosophic Numbers (TNNs) with the Weighted Aggregated Sum Product Assessment (WASPAS) method. The framework begins by capturing expert evaluations using TNNs, which effectively represent the degrees of truth, indeterminacy, and falsity inherent in subjective assessments. These evaluations are then transformed into crisp values using a novel score function that preserves the embedded uncertainty. The resulting decision matrices are aggregated into a unified structure to ensure consistency …

The Changing Style Of Change In Style: A Critical Case Study On The Aesthetics Of De-Radicalization Experiences, Bernardo Alba

Electronic Theses and Dissertations Archive

This dissertation explores how aesthetic experiences—not just belief-systems or ideologies—influence both the process of radicalization into, and de-radicalization out of, Far-right nationalist subcultures. It introduces the concept of “aesthetic conversion”: a profound transformative shift in how people experience and express themselves through artistic media and stylistic taste broadly understood (including but not limited to fashion, tattoos, music, dance, creative writing, public speaking, etc.). I argue that such transformations in aesthetic sensibility can spark profound ideological changes, including the possibility of fostering disengagement from such far-right movements. With this concept, I aim to show that aesthetic concerns, far from being incidental …

Comparative Analysis Of Risk Factors Associated With Guinea Worm Disease In Five Endemic Countries, Junerlyn Virrey Agua

Walden Dissertations and Doctoral Studies

Guinea worm disease (GWD) has persisted in a small number of endemic countries despite decades of eradication efforts. Ongoing GWD transmission in these countries underscores the need to examine behavioral, environmental, and surveillance-related drivers. The purpose of this quantitative study was to assess associations among risk factors, including dog tethering, pond treatment with Abate, and community awareness, and GWD incidence. The study also examined the relationship between climate-related environmental factors and GWD case distribution, as well as the influence of awareness levels on GWD rumor reports. Guided by the PRECEDE–PROCEED framework, this retrospective secondary analysis used data from national eradication …

Volume Ii | Issue I | 2025

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

No abstract provided.

Note For Quadripartitioned Neutrosophic Offset, Pentapartitioned Neutrosophic Offset, And Heptapartitioned Neutrosophic Offset, Takaaki Fujita

Neutrosophic Systems with Applications

Neutrosophic sets assign each element three independent membership values—truth, indeterminacy, and falsity—and their partitioned extensions introduce additional components subject to sum-bounded constraints. Notable examples include quadripartitioned, pentapartitioned, and heptapartitioned neutrosophic sets. The O set concept further extends this framework by allowing membership values outside the standard [0, 1] interval, including negative values and values exceeding one. In this paper, we introduce and analyze the Quadripartitioned Neutrosophic O set, Pentapartitioned Neutrosophic O set, and Heptapartitioned Neutrosophic O set. These extensions are intended to enhance the expressiveness of neutrosophic theory and to stimulate further research in neutrosophic and fuzzy uncertainty.

Restrictions On Veto Power: Holding The Permanent Five Accountable In The Face Of Intervention And Peacekeeping Operations, Theo Aldrighi

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

ABSTRACT: This article examines the structural constraints of the United Nations Security Council, with a focus on the veto power of its permanent members and its implications for intervention and peacekeeping. Through a realist lens and grounded in structural analysis, it contends that the recurrent paralysis of the Council in the face of mass atrocities stems from entrenched power asymmetries. The paper advances a bifold proposal: the adoption of the French-Mexican initiative to suspend veto use in cases of mass atrocities, and the entrenchment of the Council’s authority to authorize the use of force under defined conditions. Drawing on case …

Clickbait Economics: When Narratives Outshine Fundamentals, Esther Eisenstat

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

No abstract provided.

Development Analysis Of South Africa: Potential Impacts Of The Democratic Alliance’S Presence In The New Coalition, Mitchell Susswein

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

No abstract provided.

Quality Improvement Project Implementing Test Anxiety-Reducing Methods In Senior-Level Nursing Students, Ashley Brooke Gray

Doctor of Nursing Practice Projects

Test anxiety is a common occurrence among university students, particularly nursing students. The purpose of this Doctor of Nursing Practice (DNP) quality improvement project was to address the problem of test anxiety among senior-level nursing students and the lack of faculty intervention in a Bachelor of Science in Nursing (BSN) program. This DNP project aimed to increase awareness of test anxiety among nursing students and provide faculty development training on identifying symptoms, utilizing the Westside Test Anxiety Scale (WTAS), and implementing test anxiety-reducing measures in the classroom. The DNP student provided training to senior-level nursing faculty in integrating relaxation methods, …

Ai-Enabled Innovations In Automated Essay Scoring And Feedback Systems, Michael J. Murff

Theses and Dissertations

This dissertation examines the evolution and educational implementation of Automated Essay Scoring (AES) systems, with particular focus on generative artificial intelligence integration in educational assessment. Through a two-article format, this research addresses the persistent gap between technical capability and educational adoption that has characterized AES development over seven decades. The first article presents a comprehensive methodological review analyzing 122 studies spanning AES evolution from foundational computational linguistics through contemporary hybrid systems. Despite achieving strong correlations with human scoring, modern AES systems face resistance due to validity concerns and misalignment with pedagogical values, revealing an "adoption paradox" where technical sophistication often …

Under The Sea And Into The Future With Darwin, Verne, & Wells: Evolutionary Ideas In Early Science Fiction Literature And Atomic Age Adaptations, Suzette K. Forston

Theses and Dissertations

In the latter half of the nineteenth century, Charles Darwin's theories challenged traditional ways of thinking about the world so dramatically that his writings inspired the formation of a new genre: science fiction. Two pioneering authors, Jules Verne and H. G. Wells drew from Darwin's writings in their classic novels, 20,000 Leagues Under the Seas (1870) and The Time Machine (1895). Though the two authors are often compared because they were both early science fiction authors, they approached Darwinian theory in different ways. Verne uses a more extrapolative approach and focusing on specific details of Darwin's texts to tell a …

Gamete Size Is Essential For Understanding Sex And Sexual Selection In Humans, Animals, Plants, And Algae But Configurations Of Sex-Linked Traits Are Practically Important For Understanding Sex, David A. Frederick

Psychology Faculty Articles and Research

"First, I briefly highlight recent discussions of sex and how they contrast with a gametic central understanding of sex in the executive order. I then provide some background on why gametes have been central to defining sex across species in evolutionary biological sciences. Understanding this perspective is important because it helps understand the competing frames people are using when they talk of sex as binary instead of as a spectrum or a multidimensional configuration of traits. The gametic central framing is essential for understanding sex and sexual selection across species, whereas the multidimensional configuration framing is practically useful in medical, …

Some Properties Of Neutrosophic Cubic Hypersoft Sets, Lubna Nayab, Muhammad Gulistan, Fawad Hussain

Neutrosophic Systems with Applications

This study addresses the limitations of NCS in managing uncertainties associated with multiple attributes and their further bifurcation. To address this challenge, we propose a generalization of the neutrosophic cubic soft set, introducing the concept of "neutrosophic cubic hyper soft set." Within this framework, we define internal and external neutrosophic cubic hypersoft sets, along with operations such as P-intersection, P-union, P-restricted union, P-extended intersection, P-OR operator, P-AND operator, R-intersection, R-union, R-restricted union, R-extended intersection, R-OR operator, R-AND operator, complement, and relative complement of neutrosophic cubic hyper soft sets. The study explores and presents relevant results, demonstrating the enhanced capability of …

Application Of Multi-Criteria Decision Analysis For Quantifying Responsibility In Ml-Based Intrusion Detection System, Mona Mohamed, Zekra Sakr

Neutrosophic Systems with Applications

With the swift growth in Internet of Things (IoT), certifying secure and trustworthy networks has turned to be a critical challenge, particularly as IoT devices are increasingly vulnerable to sophisticated cyberattacks. As a remedy, intelligent intrusion detection systems (IDS) evolved as promising solutions in recent years, but deciding on the appropriate model remains difficult because of competing performance and trustworthiness criteria. To this end, this paper explores a novel application of an ML-augmented decision-making framework to enhance security-related decision-making in IoT environments. The framework systematically evaluates and ranks ML-based IDS systems according to different evaluation criteria with distinct trade-offs, including …

Extracellular Vesicles For Clinical Diagnostics: From Bulk Measurements To Single-Vesicle Analysis, Hai Linh Tran, Wenshu Zheng, David A Issadore, Hyungsoon Im, Yoon-Kyoung Cho, Yuanqing Zhang, Dingbin Liu, Yang Liu, Bo Li, Fei Liu, David Tai Wai Wong, Jiashu Sun, Kun Qian, Mei He, Meihua Wan, Yong Zeng, Ke Cheng, Tony Jun Huang, Daniel T Chiu, Luke P Lee, Lei Zheng, Andrew K Godwin, Raghu Kalluri, Steven A Soper, Tony Y Hu

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) play a crucial role in intercellular communication, signaling pathways, and disease pathogenesis by transporting biomolecules such as DNA, RNA, proteins, and lipids derived from their cells of origin, and they have demonstrated substantial potential in clinical applications. Their clinical significance underscores the need for sensitive methods to fully harness their diagnostic potential. In this comprehensive review, we explore EV heterogeneity related to biogenesis, structure, content, origin, sample type, and function roles; the use of EVs as disease biomarkers; and the evolving landscape of EV measurement for clinical diagnostics, highlighting the progression from bulk measurement to single vesicle …