Digital Commons Network^™

Too Cool For Camouflage?: The Effects Of Dive-Related Thermal Loss On Body Coloration In A Semi Aquatic Lizard, Lyra Lu, Alexandra Martin

Research Days Posters 2025

Rapid body color change is well documented in animals, but the variety of environmental factors that induce this change are not fully understood. Anolis aquaticus is a tropical lizard with rapid body color changes and that uses colder-than-average refugia, namely diving underwater for extended periods, to flee from predators. Using underwater refugia causes these lizards to lose several degrees of body heat. This research tested the relationship of low body temperatures on body coloration. First, an observational study was conducted in the field of the correlation between body temperature and body color. Then, body temperature was experimentally reduced in the …

No Evidence For Sex-Specific Visual Acuity In Anolis Aquaticus, Samantha Garnsey, Janelle Talavera, Lindsey Swierk

Research Days Posters 2025

Sex differences in sensory perception are widespread among animals, driven by sex-specific reproductive challenges. Males and females often exhibit different sensory abilities, such as in visual acuity; for example, in Heliconius butterflies, males exhibit greater visual acuity due to their mate-seeking behaviors. This study examined this idea in Anolis aquaticus, a semi-aquatic lizard with sexual dimorphism. Males court females using a colorful throat fan (dewlap), which females use to select mates. It is predicted that females will have greater visual acuity than males, given their reliance on visual signals for mate choice. A custom-built apparatus was used to test 45 …

Class Actions And Environmental Justice: Are Lawsuits Driving Real Change?, Sadie Berg

Research Days Posters 2025

How effective are class action lawsuits in implementing environmental change? In answering this question through meta-analysis, a focus will be placed on cancer clusters as a general theme. Every year there are several different cases by which plaintiffs attempt to obtain compensation for troubles caused by hazardous chemicals such as asbestos, polychlorinated biphenyls (PCBs), perfluoroalkyl and polyfluoroalkyl substances (PFAS), to name a few. The formation of the Environmental Protection Agency (EPA) in the early 1970’s, along with the enforcement of protective litigation, were used to put an end to the use of these dangerous chemicals. All of the data collected …

The Effects Of Prenatal Ethanol Exposure On Development And 24-Hour Ethanol Consumption During Adolescence, Princess Pokharel, Zoe Silverman, Hodaya Katz, Dehaven R. Mccray, Monica M. Juarez-Barnes, Shafin Thahseen, Ani Kuke, Abigail M. Kelley, Marvin R. Diaz, Anushree N. Karkhanis

Research Days Posters 2025

Prenatal ethanol exposure (PAE) disrupts normal brain development resulting in behavioral deficits later in life, including a propensity to develop alcohol use disorder. This study investigated the effects of PAE on adolescent drinking patterns, using a single-bottle-choice drinking paradigm in Long Evans rats. PAE was hypothesized to increase 24-hour ethanol consumption. Interestingly, data showed that PAE female rats consumed less ethanol than their non-exposed counterparts, while male rats exhibited no significant differences in ethanol consumption. All female rats consumed higher amounts of ethanol than male rats, regardless of exposure. Additionally, PAE male and female rats had increased average body masses …

The Effect Of Diet And Exercise On Mood And Self Motivation, Megan Amante, Alex De Vries, Cassidy Howe, Thomas Marto, Christian Pena, Aliya Terrana

Research Days Posters 2025

Eating tyrosine-rich food may promote motivation and mental well-being. The purpose of this study was to evaluate the effectiveness of a tyrosine-rich diet in promoting aerobic, strength training, or both forms of exercise and its impact on positive mood among participants. An anonymous online survey was administered through social media. This included basic demographic questions along with questions about diet, exercise, and self-motivation. The data for this study were analyzed using Pearson’s Correlation Analysis in SPSS version 28. The results showed that a negative correlation exists between eating nuts as well as exercising and feeling hopeless (p < 0.05). There was a significant positive correlation between the length of time exercising per session and the ability to set goals for oneself and keep track of progress (p < 0.01). There is a positive correlation between eating a tyrosine-rich diet and exercising with motivation.

Predicting 18-Month M-Chat-R/F With Pediatractmv3.0 Motor And Social/Communication/Cognition Domains, Ryan Krebs

Master's Theses and Doctoral Dissertations

Background. The developmental cascade framework suggests early delays in one system can impact others. Infants born preterm or with autism spectrum disorder (ASD) often show such delays. Methods. The study included 498 infants enrolled in PediaTracTM a novel caregiver-report measure. The convergent validity of PediaTrac with the Ages and Stages Questionnaire (ASQ-3) was examined, along with its ability to predict ASD risk at 18 months using cross-sectional (9- and 12-month) and longitudinal (0–12-month) latent traits of motor (MOT) and social/communication/cognitive (SCG) abilities. Results. Strong convergent validity was found between PediaTrac and ASQ-3 domains at both time points. MOT at 9-months …

The Impact Of Facility Dogs On College Students' Stress Management And Emotional Regulation, Anna Reichert

Senior Honors Theses and Projects

College is a demanding transitional time where students experience new friendships and personal growth. During this time, mental health issues can surface, which impact emotional well-being. Studies have shown that dogs reduce stress, anxiety and depression, encourage exercise, lower blood pressure, and raise oxytocin and dopamine levels (American Heart Association, 2021). Eastern Michigan University introduced their own facility dog, Tinker, a two-year-old golden retriever. Since Fall 2024, she has provided emotional comfort and relief to students and the campus community. Students were surveyed on stress levels and if and how Tinker made an impact. Survey results show Tinker’s effect on …

Farm Profit Impacts Of Consecutive Drought Years Under Climate Scenarios In Southwestern Australia, Sud Kharel, Kevin J. Foster, Meredith M. Guthrie, Ross Kingwell

Climate Science Research Articles

Climate projections for southern Australia indicate an increased likelihood of years of consecutive droughts. How resilient are farm businesses and their farming systems to recover from episodic drought? This study assesses the farm economic and financial impacts of consecutive droughts in southwest Australia. Bioeconomic simulation modelling of farm businesses with different farming systems at three locations is used to examine the long-term financial consequences of consecutive droughts. Various key factors affecting those consequences are examined. Farm location, farming system and starting equity are found to be the main determinants of how quickly a farm business can financially recover from the …

Cultural Cognition And The Thoughtful Judge, Jack Whiteley

Indiana Law Journal

That judges follow what the law is, and not what they wish it was, is a requirement of the rule of law. At the same time, scholars, lawyers, and judges often say that judges’ values influence their decisions. Connecting these two ideas has generated a conversation about the relationship between law, ideology, and politics.

Recently, part of this conversation has focused on a theory called cultural cognition. The theory offers an account of how people’s values shape how they interpret things without their noticing. People whose values tend toward hierarchy sometimes perceive facts differently than people whose values tend toward …

Common Law Executive Privilege(S), Jonathan Shaub

Indiana Law Journal

There are few Supreme Court cases that enjoy as much widespread support as the unanimous decision in United States v. Nixon. The recent pitched battles between Congress and the executive branch have made apparent the vast disagreement between the two branches over access to information. But that disagreement does not extend to Nixon, the unquestioned jurisprudential foundation for the doctrine of executive privilege. Closer inspection shows, however, that this foundation is not a stable one, but one constructed from unnecessary, ill-considered dicta.

As this Article demonstrates, Nixon conflated the constitutional question about one branch’s power vis-à-vis another branch with an …

The Anti-Discriminatory Right To Travel, Noah Smith-Drelich

Indiana Law Journal

Travel rights and travel restrictions shape nearly every part of society, moderating where and how we go about our daily lives. Yet a central aspect of travel has gone largely unnoticed in the legal literature. Oppressive governments have routinely restricted free movement as a principal means of effectuating discrimination. And travel rights, as a result, have always had a strong anti-discriminatory valence. From the Magna Carta to Blackstone’s Commentaries to the Constitution itself, rights to travel have consistently emerged from struggles against discrimination.

This Article makes several independent but related contributions. First, the Constitution’s protections of travel have a strong …

Playing Through Music History: The Contextualizing Function Of Western Historical Music In Fantasy Role-Playing Video Games, Laney Abigail Sheehan

Wayne State University Theses

This thesis focuses on the presence of Western historical music in contemporary video games. Through a combination of music-theoretical analysis, iconography, and Peircean semiotics, the author demonstrates that the nondiegetic soundtracks of fantasy role-playing video games utilize elements of major style periods in music history—including the Middle Ages, Renaissance, Baroque, and Classical eras—to enhance existing representations of time and place in their visual environments. This phenomenon is particularly apparent in three games, which serve as case studies: Baldur’s Gate 3 (2023), The Legend of Zelda: Breath of the Wild (2017), and Elden Ring (2022). Ultimately, the project contributes research to …

The Future Of Shipping At The Biodiversity-Climate Nexus : Round Table Report, Mary S. Wisz, Fabio Berzaghi, Mikaela Gomez, Maud C. Quinzin, Renis Auma Ojwala, Emily Nuckolls

Reports

This report presents the outcomes of a cross-disciplinary Round Table hosted by the World Maritime University (WMU) from May 13-15, 2024, in Malmö, Sweden. The event brought together 51 experts from academia, industry, NGOs, and international organizations, including the IMO, to explore shipping’s role at the biodiversity-climate nexus. The Round Table had a particular focus on the impacts of shipping that are currently unregulated or under-regulated, and opportunities to address biodiversity loss and pollution as the sector decarbonizes. The report highlights the need to apply comprehensive, ecosystem-based approaches to effectively manage shipping's impacts, including cumulative impacts, on the environment, people, …

Arkansas Baseball, 2025, University Of Arkansas, Fayetteville. Athletics Media Relations

Arkansas Baseball

No abstract provided.

Should Copyright Protect Racist Works? A Review Of Intellectual Property And Immorality: Against Protecting Harmful Creations Of The Mind By Ned Snow, Cathay Smith

Texas A&M Journal of Property Law

This Essay reviews Ned Snow’s provocative book, Intellectual Property and Immorality: Against Protecting Harmful Creations of the Mind, and critically examines the intersection of copyright law and morality. It explores the ethical dimensions of copyright protection and examines whether works which fail to advance societal progress, as defined by Snow, should be ineligible for copyright. Drawing parallels between pornography and offensive and racially insensitive classic children’s literature and films, this Essay considers the broader implications of denying copyright to immoral works, including the potential for increased dissemination of harmful content, the challenge of aligning copyright with evolving moral standards, …

From Objects To Relationships: Reviving Connectivity Through Collaborative Artmaking, Carolina Blatt-Gross

Journal of Social Theory in Art Education

A shortage of pro-social opportunities during the pandemic brought to the fore a longer, deeper trend toward disconnection. With the broader emphasis on individualized academic achievement compounding pandemic-induced social disenfranchisement, schools and communities are struggling to revive a sense of connectivity and belonging. The arts, on the other hand, have long been associated with social outcomes, historically generating group cohesion and inherently offering participants a sense of unity and synchronicity through collaborative artmaking. Applied to educational settings, pinpointing the concrete aspects of art education that beget social capital and connectedness is a more difficult task. This investigation examines the potential …

Ovarian Response, Endocrine Environment, And Pregnancy-Associated Glycoproteins In Beef Cows Using The 7 & 7 Synchronization Protocol, Hunter Haberman

Electronic Theses and Dissertations

This Review aims to provide an overview of the bovine estrous cycle and pregnancy establishment, beginning with follicular development, luteolysis, maternal recognition of pregnancy and early embryonic development. Manipulating the estrus cycle with synchronization protocols is a critical aspect of the beef industry and has greatly improved the efficiency of artificial insemination. This review will evaluate various strategies to synchronize estrus from the very basic to more advanced synchronization protocols. There are many factors that affect the success of the protocol, and many studies have been done to evaluate the estrus cycle to reach the highest level of success from …

Borreliosis And Doxycycline Treatment Disrupt Gut Microbiota And Immune Responses In Nonhuman Primates, Ethan G. Napier, Isaac R. Cinco, Sheridan B. Wagner, Ethan V. Stuart, Qi Qiao, Joshua Taylor, Brian Stevenson, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Borrelia burgdorferi (Bb) is the spirochete that causes Lyme disease (LD). Transmission to humans occurs via bites of infected Ixodes spp. ticks. Doxycycline is often used to treat LD patients, which is sometimes delayed due to current diagnostic challenges. Recently, several lines of evidence show dysbiosis of the gut microbiome in LD patients, which may be a host factor contributing to pathogenesis and symp tomology but is still an understudied area in the field. To address this knowledge gap, we longitudinally compared the immune response and gut microbial composi tion of Japanese macaques after intradermal infection with Bb strain 297 …

Feeding The System: A Political Ecology Of Stakeholders In The Soy Value Chain, Calli E. Oneal

Pitzer Senior Theses

This thesis presents a holistic analysis of power dynamics within the global soybean value chain, through the evaluation of the trade relationship between Brazil and the European Union. In order to identify how critical decisions regarding sustainability are concentrated among a few dominant actors. Eight core stakeholder groups are mapped: land-use conversion actors, producers, traders, agro-input providers, financial institutions, regulatory bodies, NGOs, and key consumers, including meatpacking and animal feed companies. Multinational traders, who control approximately 80% of global soy trade, act as sustainability gatekeepers through their lobbying influence and control over supply chain narratives and are disincentivized from human …

Corchorus Olitorius Exhibits Antiproliferative Potential Supported By Metabolic Profiling And Integrative Biological Analyses, Maha R.A. Abdollah, Salma Sameh, Ahmed Elissawy, Eman Al-Sayed, Rola Labib, Lan Ye, Fang-Rong Chang, Abdel Nasser B. Singab

Pharmacy

Herbal nutraceuticals could be employed as alternative or complementary routes for alleviating cancer. Corchorus olitorius (Malvaceae) was employed traditionally in the management of tumors. The study aimed to investigate the antiproliferative activity of C. olitorius leaves. In vitro cytotoxic and anti-angiogenic activities of C. olitorius were estimated. The bioactive fraction was subjected to in vivo study on BALB/ c female mice using Ehrlich Ascites Carcinoma model. UPLC-ESI-MS/MS analysis was done to determine the phytometabolites followed by in silico studies on the major identified compounds. The bioactive fraction possessed potent in vitro activity against A549 cells with IC50 = 7.8 µg/mL …

Reducing Food Waste Among College Students Through Educational Messaging, Olivia Husmann

Schultz-Werth Award Papers

The environmental and societal impacts of food waste continue to be demonstrated in reports, governmental documents, and independent research. While it is not the leading source of food waste, the foodservice industry has an important role in bringing awareness of the detriments of waste to its consumers. The following paper offers observations on food waste behaviors in college students at South Dakota State University (SDSU), specifically at Larson’s Commons dining hall during the 2024 spring semester. The study explores whether advocating for decreased food waste through infographics at dining tables changes the amount of food and drink wasted during the …

Aluminum In Beverages And Foods: A Comprehensive Compilation Of Regulations; Concentrations In Raw, Prepared, And Stored Beverages And Foods; And Intake, Robert Yokel

Pharmaceutical Sciences Faculty Publications

The history and controversy concerning aluminum use in beverage and food preparation and storage are reviewed. This review on aluminum in drinking water, foods, and beverages updates and exceeds prior reviews. Country and international organization regulations that permit incorporation of aluminum containing food additives, their use limit, and purposes are presented. The aluminum concentration in beverages and foods consumed worldwide was gleaned from approximately 2100 sources available to the author. The approximately 17700 values are compiled in 175 tables by beverage or food category that include the analytical method used, sample source, and reference. The tables are posted on the …

Development Of A Ghrelin Deacylase To Attenuate Drug Reward And Associated Effects Of Methamphetamine, Madeline J. Stewart, Huimei Wei, Nellore Bhanu Chandar, Fang Zheng, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Publications

All addictive substances directly or indirectly interact with the dopamine reward system to alter the brain’s dopamine receptor activities. It is essential for a truly effective addiction medication to attenuate substance reward and normalize the brain’s physiological functions. Conventional pharmacological intervention approaches to the treatment of substance addiction usually aim to develop and deliver a potential therapeutic agent to the brain to directly block or decrease actions of the substance or its therapeutic target in the brain. However, it is a grand challenge to attenuate the substance reward without affecting the normal physiological functions of brain receptors or transporters. Here, …

Effects Of Biased Analogues Of The Kappa Opioid Receptor Agonist, U50,488, In Preclinical Models Of Pain And Side Effects, Ross Van De Wetering, Loan Y. Vu, Lindsay D. Kornberger, Dan Luo, Brittany Scouller, Sheein Hong, Kelly F. Paton, Thomas E. Prisinzano, Bronwyn M. Kivell

Pharmaceutical Sciences Faculty Publications

Kappa opioid receptor (KOR) agonists have well-established antinociceptive effects. However, many KOR agonists have negative side effects, which limit their therapeutic potential. Some researchers have suggested that the development of biased agonists that preferentially stimulate KOR G-protein pathways over β-arrestin pathways may yield drugs with fewer adverse side effects. This was investigated in the current study. We describe the synthesis and characterization of three U50,488 analogues, 1, 2, and 3. We evaluated the acute and chronic antinociceptive effects of these compounds in mice using the warm-water tail flick assay and in a paclitaxel-induced neuropathic pain model. Side …

Effects Of Fentanyl-Adulterated Methamphetamine On Circulating Ghrelin In Rats, Huimei Wei, Elise C. Maul, Shawn Park, Kaniz Fatema, Daniel J. Peter, Chang-Guo Zhan, Fang Zheng

Pharmaceutical Sciences Faculty Publications

The appetite hormone ghrelin influences biological processes that are responsible for substance use disorder, which is related to alcohol and most abused drugs including cocaine, methamphetamine, nicotine, etc. In general, upregulation of the ghrelin system enhances drug cravings and substance use. Studies reported in the literature consistently demonstrated that the ghrelin system is associated with stimulants. However, research on opioids in combination with methamphetamine has not been reported. In this study, we examined the relationship of circulating ghrelin with the polydrug use of fentanyl and methamphetamine in male Sprague-Dawley rats, demonstrating for the first time that concurrent use of fentanyl …

Effects Of Fentanyl-Laced Cocaine On Circulating Ghrelin, Insulin, And Glucose Levels In Rats, Huimei Wei, Elise C. Maul, Annet Kyomuhangi, Shawn Park, Maddilynn L. Mutchler, Chang-Guo Zhan, Fang Zheng

Pharmaceutical Sciences Faculty Publications

Opioid mixed with cocaine has been increasingly implicated in overdose deaths, including both intentional co-use of opioid and cocaine and fentanyl-adulterated drug supply. As ghrelin plays an important role in drug reward and can also influence insulin, this study aimed to assess responses of the circulating ghrelin, insulin, and glucose levels to the combined use of fentanyl and cocaine (a polydrug) in rats by performing combined animal behavioral experiments and biochemical analysis. The experimental data consistently revealed that the fentanyl and cocaine co-use can significantly elevate both the acyl-ghrelin and desacyl-ghrelin levels and significantly decrease the insulin level without significant …

Fluorescence-Guided Resection Of Gl261 Red-Fluc And Trp-Mcherry-Fluc Mouse Glioblastoma Tumors, Louis T. Rodgers, Bryan J. Maloney, Anika M. S. Hartz, Björn Bauer

Pharmaceutical Sciences Faculty Publications

Background: Most preclinical studies on glioblastoma (GBM) fail to provide translational utility in the clinic. Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) improves tumor resection, disease prognosis, and, thus, patient outcomes. Given the critical role of surgery in managing recurrent GBM, it is essential to incorporate surgical elements into preclinical models to accurately reflect clinical scenarios and enhance translational success. However, existing protocols for 5-ALA-guided resection in preclinical models are limited and often lack clinical relevance.

Methods: To address this gap, we developed a novel protocol for the 5-ALA-guided resection in two mouse GBM models: TRP-mCherry-FLuc and GL261 Red-FLuc.

Results: The …

Development Of Zafirlukast Analogues For Improved Antithrombotic Activity Through Thiol Isomerase Inhibition, Justine A. Keovilay, Kaitlind C. Howard, Kirk A. Taylor, Sabeeya Khan, Sienna E. Wurl, Melanie K. Szahaj, Tanya Sage, Nishad Thamban Chandrika, Caixia Hou, Oleg V. Tsodikov, Jonathan M. Gibbins, Sylvie Garneau-Tsodikova, Daniel R. Kennedy

Pharmaceutical Sciences Faculty Publications

Background:   Thiol isomerases play essential and nonredundant roles in platelet activation, aggregation, and thrombus formation. Thiol isomerase inhibitors have the potential to overcome the 2 major drawbacks of current antithrombotic therapies, as they target both arterial and venous thrombosis without enhancing bleeding risks. Recently, a Food and Drug Administration–approved drug, zafirlukast (ZAF), was shown to be a promising pan-thiol isomerase inhibitor. The objective of this study is to develop analogues of ZAF with optimized thiol isomerase inhibition and antithrombotic activity.   Methods:   Thirty-five ZAF analogues were tested in an insulin turbidometric assay for thiol isomerase inhibition. Analogues were tested for platelet …

Enhancing Topical Delivery Of N-Acetylcysteine And Collagen Via A Novel Electrospun Collagen/Pmma Nanofibrous Mats As Facial Mask Development: Nanofibers Optimization And In Vitro Experiments, Abdullah Elbadry, Elbadawy Kamoun, Mahmoud Sabahy, Mohamed Helmy, Mahmoud Khaled, Shahira Elmosalamy, Noura Eissa

Nanotechnology Research Centre

No abstract provided.

Identification Of Host-Pathogen Protein Interactions: Yeast Two-Hybrid Analysis Of Sars-Cov-2 Nsp10 And Human Cellular Proteins, Antonios Argyriou

Selected Full-Text Master Theses 2021-

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has resulted in over 774 million cases and 7 million deaths worldwide, establishing it as one of the most devastating pandemics in recorded history. While current therapeutic approaches primarily target viral entry mechanisms and specific enzymes, the limited understanding of non-structural protein functions hinders the development of comprehensive antiviral strategies. This research focuses on Nsp10 (non-structural protein 10), a highly conserved 139-amino acid protein essential for viral mRNA capping and replication. Nsp10 serves as a critical cofactor in the formation of methyltransferase complexes with Nsp14 and Nsp16, playing a vital role in viral …