Digital Commons Network^™

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Navigating Ai-Nature Frictions: Autonomous Vehicle Testing And Nature-Based Constraints, Prerona Das, Orlando Woods, Lily Kong

Research Collection College of Integrative Studies

In cities, the application of Artificial Intelligence (AI) is being directed towards transforming different aspects of urban life. These applications take material form in urban spaces, with autonomous vehicles (AVs) providing a prominent example. AI systems rely on large volumes of data on their surroundings to refine the algorithms and enhance the accuracy of prediction for operational efficiency and safety. However, such algorithmic learning and execution can present challenges when dealing with the unpredictable, complex, and dynamic aspects of urban spaces. Nature is a paradigmatic example of such unpredictability, because natural phenomena usually defy consistent patterns and precise data-based modelling. …

A Longitudinal And Multimodal Simulation-Based Curriculum Improved Internal Medicine Residents' Confidence In Procedures, Point-Of-Care Ultrasound, And Clinical Decision-Making., Sarah Grebennikov, Aisha Imam, Megan Kang, Aimee E Willett, Brad Gable, Sanjay Patel

Medical Education Articles

Introduction Internal medicine training has historically relied on classroom-based lectures, typically delivered through morning and noon conferences, which offer broad content coverage but limited experiential learning. Simulation-based education improves resident confidence, procedural ability, and clinical reasoning; yet it is often delivered in brief, standalone activities that lack longitudinal structure or integration within the broader curriculum. Few programs have a longitudinal simulation curriculum that spans the academic year and incorporates multiple modalities and topics. We developed a novel simulation-based curriculum intentionally integrated into the existing resident academic schedule to provide structured hands-on learning across multiple domains. Sessions focused on procedural and …

Mitochondria-Mediated Epigenetic Transfer Between Chondrosarcoma And Wild-Type Cells, Caleb C. J. Wyckoff

Biomedical Sciences Theses & Dissertations

Glioblastoma (GB), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), cholangiocarcinoma, and chondrosarcoma (CS) cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme exhibits transformation of alpha-ketoglutarate (αKG) into the oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers. Mitochondrial-mediated transfer between cancer cells and recipient cells is a significant event that impacts the physiology of the receiving cell, specifically the epigenetic landscape. Previous experiments indicating increased DNA methylation in mesenchymal stem cells exposed to IDH1 or IDH2 conditioned medium underscore the potential role of D2HG to alter methylation states. Additionally, the presence of …

Tracing The Journey Of Dissolved Organic Matter: From Leaf Litter Photodegradation To Microbial Processing In Tropical Streams, Samantha Nicole Sullivan

Chemistry & Biochemistry Theses & Dissertations

Dissolved organic matter (DOM) is a major reservoir of organic carbon in aquatic ecosystems and plays a central role in global carbon cycling through its transformation and remineralization to carbon dioxide (CO₂). As DOM moves from terrestrial environments into streams and rivers, its chemical composition is altered by a combination of microbial and photochemical oxidation processes that regulate both its reactivity and its persistence during transport. However, the molecular mechanisms governing these oxidative transitions, particularly in tropical ecosystems characterized by strong hydrologic seasonality and substantial inputs of plant-derived material, remain insufficiently resolved. This dissertation integrates ultrahigh-resolution mass spectrometry, optical characterization, …

Assessing The Impact Of Maternal Oral Health On The Risk Of Adverse Birth Outcomes, May Amr Salama

Health Services Research Dissertations

Preterm birth (PTB) and low birth weight (LBW) are leading causes of neonatal morbidity and mortality. Maternal periodontal disease (PD) has been increasingly linked to these adverse birth outcomes (ABOs), yet questions about causality and treatment effectiveness persist due to study design heterogeneity and potential unmeasured confounding. These gaps hinder the development of clear clinical and public health guidelines. This dissertation addresses these gaps through three interconnected studies assessing the relationship between maternal oral health and ABOs.

The first study employed a meta-epidemiological analysis of 62 original studies from nine systematic reviews to evaluate the impact of unmeasured confounding on …

Comparative Analysis Of Emergent Behaviors Of Three Drone Swarm System Models For Targeting Using Agent-Based Modeling And Simulation, Arsenio T. Gumahad Ii

Engineering Management & Systems Engineering Theses & Dissertations

This dissertation introduces a novel computational simulation framework for evaluating the emergent behaviors of three swarm drone models using Agent-Based Modeling and Simulation (ABMS). The three swarm models are a Leader-Follower swarm model based on Bruckstein's antline theory, a Flocking model based on a simplified Reynolds 'Boids’ model, and a Stigmergic model with pheromone-based coordination. The primary objective of the simulation is to evaluate the performance of these models in delivering a user-defined number of drones of each type to a target area of interest in four separate scenarios, resulting in 50,000 separate simulation trials. Each scenario was structured to …

Graduate Physical Therapy Students Perceived Benefit Of Prior Anatomy Experiences Following Their First Semester Graduate Physical Therapy Anatomy Course, Austin Alexander

EVMS School of Health Professions Theses & Dissertations

Human anatomy stands as a cornerstone prerequisite for admission into graduate-level Physical Therapy Programs. As such, prior anatomy experiences need to prepare students for success in graduate-level coursework. However, studies have demonstrated that undergraduate anatomy courses vary in their ability to predict success in graduate Physical Therapy anatomy coursework. This research aimed to utilize students' perceptions of their undergraduate anatomy experiences to predict grades in graduate-level Physical Therapy anatomy coursework. The multinomial logistic regression in this study revealed that the absence of perceived preparedness was a significant predictor of membership in the C graduate anatomy grade group. Students who did …

Benzodioxane-Benzamides Targeting Bacterial Cell Division Protein Ftsz Potentially Disrupt Slma-Mediated Nucleoid Occlusion And Reversible Biomolecular Condensation, Marta Sobrinos-Sanguino, Inés Barros-Medina, Lorenzo Suigo, Alessia Lanzini, Ermanno Valoti, William Margolin, Valentina Straniero, Begoña Monterroso, Silvia Zorrilla

Faculty, Staff and Student Publications

New strategies are urgently needed against antimicrobial resistance, a major health threat, and the different mechanisms regulating the bacterial cell division machinery offer multiple opportunities for developing novel therapeutics. FtsZ, an essential protein of this process, is targeted by multiple small molecules, and benzodioxane-benzamides (BDOBs) are among the most potent inhibitors in several bacterial species. BDOBs mechanisms are however poorly understood, particularly their impact on FtsZ's interplay with partners and ability to assemble phase-separated biomolecular condensates potentially involved in stress sensing. We show that certain BDOBs shielded FtsZ against depolymerization induced by the nucleoprotein complexes of SlmA, which inhibit Z-ring …

Caspase 3-Specific Cleavage Of Ubiquitin-Specific Peptidase 48 Enhances Drug-Induced Apoptosis In Aml, Zhanglin Zhang, Xiang Lin, Yaling Yang, Xuemei Wang, Yi Wang, Xianbao Huang, Miao Hong, Wei Gao, Hua He, M James You, Yi Yang, Guangyao Kong

Faculty, Staff and Student Publications

Dysfunction or dysregulation of deubiquitination is closely related to the initiation and development of multiple cancers. Targeted regulation of deubiquitination has been recognized as an important strategy in tumor therapy. However, the mechanism by which drugs regulate deubiquitinase is not clear. Here, we identified ubiquitin-specific peptidase 48 (USP48), a member of the ubiquitin-specific protease family highly expressed in various tumors, as a specific substrate for the activated caspase-3. During drug induced apoptosis of AML cells, activated caspase-3 cleaves USP48 through recognizing the conservative motif DEQD located at 611-614 sites of human USP48. Subsequent analysis showed that the cleavage USP48 N-terminal …

Impact Of Peripheral Circadian Misalignment And Alcohol On The Resiliency Of Intestinal Barrier And Microbiota, Laura Tran, Maliha Shaikh, Phillip A Engen, Ankur Naqib, Dulce M Frausto, Vivian Ramirez, Malia Gasteier, Zlata Bogin, Kristi Lawrence, Lijuan Zhang, Shiwen Song, Stefan J Green, Faraz Bishehsari, Christopher B Forsyth, Ali Keshavarzian, Garth R Swanson

Faculty, Staff and Student Publications

Circadian organization is involved in many gastrointestinal tract (GIT) functions such as the maintenance of intestinal barrier integrity. There is compelling evidence that perturbation of the circadian clock decreases intestinal epithelial cells' resiliency to alcohol-induced injury. One of the most common causes of circadian misalignment is wrong-time eating (largest meal at dinner) in modern societies. Yet, few studies have examined the importance of peripheral circadian rhythms of the GIT to alcohol consumption. Eating patterns during physiologic rest time, defined as wrong-time eating (WTE), misalign the peripheral circadian clock of the GIT and the body's central clock. This study aims to …

Tubulin Regulates Stability And Localization Of Stmn2 By Binding Preferentially To Its Soluble Form, Xiang Deng, Gary A Bradshaw, Marian Kalocsay, Timothy Mitchison

Faculty, Staff and Student Publications

The small, tubulin-binding protein STMN2 is highly expressed in neurons and is implicated in amyotrophic lateral sclerosis. STMN2 degrades rapidly and accumulates at axotomy sites, suggesting fast turnover is crucial for its neuroprotective function. We show that STMN2 was primarily degraded by the ubiquitin-proteasome system. Its membrane-targeting N-terminal domain promoted fast turnover, whereas its tubulin-binding domain promoted stabilization. Proximity labeling and imaging showed that tubulin binding reduced STMN2 targeting to trans-Golgi network membranes. Pull-down assays showed that tubulin binds preferentially to soluble over membrane-bound STMN2. Our observations suggest that STMN2 interconverts between a soluble, tubulin-bound form and a membrane-bound, tubulin-free …

Molecular Response To The Non-Lytic Peptide Bac7 (1-35) Triggers Disruption Of Klebsiella Pneumoniae Biofilm, Robert L Beckman I V, Berta Martinez, Flor Z. Santiago, Gabriela N. Echeverria, Bruno V. Pinheiro, Marcelo D. T. Torres, Logan Suits, Shantal Garcia, Paeton L. Wantuch, Cesar De La Fuente-Nunez, Prahathees Eswara, David A. Rosen, Renee M. Fleeman

2020-Current year OA Pubs

Klebsiella pneumoniae is becoming increasingly difficult to treat as multidrug-resistant (MDR) strains become more prevalent. The formation of biofilm heightens this threat by embedding bacterial cells in a polysaccharide-rich matrix that limits antibiotic penetration. Here we dissect the anti-biofilm bovine host-defense cathelicidin peptide fragment bac7 (1-35), exploring its anti-biofilm mechanism, evaluating its ability to curb colonization of the vital organs by hypervirulent K. pneumoniae, and testing its breadth of activity against diverse clinical isolates. Transcriptomic profiling revealed that bac7 (1-35) simultaneously compromises the bacterial membrane and inhibits ribosomal function, a dual assault that precipitates rapid biofilm collapse and blocks bacterial …

Knowledge Mapping And Visualized Analysis Of Research Progress In Onconephrology: A Bibliometric Analysis, Yiwei Wang, Shuling Fan, Wei Wang

Faculty, Staff and Student Publications

Objectives: Onconephrology is an expanding subspecialty focused on the management of cancer patients with renal injury. This study used a comprehensive bibliometric analysis to emphasize the need for cooperation between oncologists and nephrologists, exploring current trends and future research areas in onconephrology.

Methods: Relevant literature on onconephrology published between 1 January 2000 and 27 April 2024 was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection, followed by manual screening. Bibliometric analyses were performed using CiteSpace, VOSviewer, and Bibliometrix software.

Results: A total of 1,853 publications, including 1,647 articles and 206 reviews, by 11,606 authors …

Secretory Iga Dysfunction Underlies Poor Prognosis In Fusobacterium-Infected Colorectal Cancer, Ilseok Choi, Kyung-A Kim, Sang Cheol Kim, Donghwan Park, Ki Taek Nam, Jun Hyung Cha, Seungbyn Baek, Junha Cha, Hye-Yeong Jo, Minsun Jung, Melody Y Zeng, Irina Matei, Susan Bullman, Joong Bae Ahn, Yoon Dae Han, Han Sang Kim, Insuk Lee

Faculty, Staff and Student Publications

Fusobacterium nucleatum (Fn) is commonly enriched in colorectal cancer (CRC) and associated with poor outcomes, though its mechanisms remain unclear. Our study investigated how Fn affects the tumor microenvironment through single-cell transcriptomic analyses of 42 CRC patient tissues, comparing Fn-positive and Fn-negative tumors. We discovered that Fn impairs IgA plasma cell development and secretory IgA (sIgA) production by disrupting communication with tumor-associated macrophages. Additional experiments in germ-free mice, together with our re-analysis of a publicly available single-cell RNA-seq data set from a CRC mouse model with an intact gut microbiome–both models having been orally gavaged with Fn–jointly validated the causal …

Gene Expression Reveals The Pancreas Of Aselli As A Critical Organ For Plasma Cell Differentiation In The Eurasian Common Shrew, William R. Thomas, Cecilia Baldoni, Tanya M. Lama, Yuanyuan Zeng, Angelique P. Corthals, Dominik Von Elverfeldt, John Nieland, Dina K.N. Dechmann, Liliana M. Dávalos

Biological Sciences: Faculty Publications

Background: Almost all mammals rely on the thymus and bone marrow to generate and differentiate B and T cells essential for adaptive immunity. A few members of the family Soricidae, or true shrews within Eulipotyphla, have also evolved an enlarged pancreas of Aselli, a kidney-sized organ hypothesized to serve this primary immune role, and whose gene expression profile is unknown. Results: Here we introduce transcriptomes of juvenile Eurasian common shrews (Sorex araneus, family Soricidae) pancreas of Aselli. We compare these to those of the shrew spleen and chick bursa of Fabricius, an analogous, bird-specific organ, and explore differential expression overlaps …

Effects Of Exercise Or Diet Or Combined Interventions On Treatment Efficacy Of Chemotherapy For Cancer: A Systematic Review, Cristina Crespo-Garcia, Francesco Bettariga, Dennis R. Taaffe, Carolyn J. Peddle-Mcintyre, John P. Campbell, Emily Jeffery, Anna Maria Markarian, Anita Borsati, Alice Avancini, Sara Pilotto, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Purpose of Review: While exercise and dietary interventions in patients with cancer undergoing chemotherapy have been demonstrated to be safe and feasible and improve patient-reported outcomes, the effects on treatment efficacy have not been widely examined and remain unclear. This review aimed to examine the effects of exercise, dietary, and combined interventions on tumour response and time-to-event outcomes in patients with cancer undergoing chemotherapy. Recent Findings: A systematic review of intervention studies was conducted based on PRISMA guidelines Databases searched were PubMed, Medline, CINAHL, Embase, and Web of Science. Methodological quality and risk of bias were assessed using the RoB2 …

Extracellular Domain Shedding Of Trop2 Activates Egfr Signaling To Drive Prostate Cancer Metastasis, Shiqin Liu, En-Chi Hsu, Merve Aslan, Fernando Garcia-Marques, Michelle Shen, Alifiani B Hartono, Francisco Solano, Kewei Le, Hyeonji Hwang, Chung S Lee, Abel Bermudez, Rosalie Nolley, Donna M Peehl, James D Brooks, Michael A Liss, Sharon J Pitteri, Tanya Stoyanova

Faculty, Staff and Student Publications

UNLABELLED: Metastasis is the main cause of prostate cancer-associated deaths, highlighting the urgent need to determine the mechanisms underlying prostate cancer progression. TROP2 (also known as tumor-associated calcium signal transducer 2) is an oncogenic transmembrane surface protein that is highly expressed in metastatic prostate cancer. Naturally occurring cleavage of TROP2 leads to a release of the TROP2 extracellular domain (TECD) into the extracellular environment. In this study, we identified an important functional role of TECD in prostate cancer metastasis. TECD was detectable in media from prostate cancer cells and serum from patients with clinically significant prostate cancer. Although shed TECD …

Triggering Sarcomerogenesis: Examining Key Stimuli And The Role Attributed To Eccentric Training—Historical, Systematic, And Meta-Analytic Review, Anthony J. Blazevich, Walter Herzog, João Pedro Nunes

Research outputs 2022 to 2026

Background: Serial sarcomere number (SSN) critically influences muscle function and is hypothesized to protect against injury. While most evidence for SSN addition comes from non-human animal studies, eccentric exercise is often proposed as a key stimulus due to its association with increased fascicle length in humans. However, the most efficient exercise stimuli and the effectiveness of eccentric training in increasing SSN remain unclear. The objective of this study was to provide a detailed historical overview of research exploring the mechanical factors regulating muscle/fiber length and its relationship with function, and to explore more recent evidence that eccentric muscle contractions might …

Hamstring Strength And Architectural Properties Are Associated With Running Biomechanics, Nicholas Ripley, Christopher Bramah, Paul Comfort, John Mcmahon

Research outputs 2022 to 2026

Applied muscular strain and hamstring strain capacity have a joint interaction on hamstring strain injury (HSI) with modifiable risk factors frequently assessed. However, to date there is limited observations on the interaction between these factors. The purpose of the present study was to observe if spatiotemporal characteristics, running kinematics and muscle activation were related to modifiable risk factors of HSI. Twenty-two competitive team sport athletes (24.7 ± 4.3 years, 1.82 ± 0.07 m, 84.9 ± 8.5 kg) participated whereby the Bicep femoris long head (BFLH) fascicle length assessed via ultrasound and isokinetic eccentric hamstring strength was assessed. With running assessment …

The Effects Of Acute And Chronic Exercise On Lipocalin-2 In Middle-Aged And Older Adults: A Randomized Control Trial, Carlie Bauer, Marc Sim, Cassandra Smith, Rhiannon Healy, Andrew Garnham, Navabeh Zare-Kookandeh, Elizabeth Byrnes, Mary N. Woessner, Joshua R. Lewis, Itamar Levinger

Research outputs 2022 to 2026

Objective Chronically elevated circulating lipocalin-2 (LCN2) levels are implicated in poor energy regulation, increased cardio-metabolic disease risk, and poor physical function. Exercise is known to improve these factors, but whether LCN2 is modifiable by exercise is not clear. We examined the effect of acute and chronic exercise on LCN2 levels and whether this relates to glucose regulation, body composition, and physical function. Design and methods Thirty-three middle-aged and older adults (45–84 years, median body mass index 26.21 kg/m²) completed an acute high-intensity interval exercise session (HIIE). Participants were randomized to 4 weeks of high-intensity interval training (HIIT) or …

Is Noise Exposure Associated With Impaired Extended High Frequency Hearing Despite A Normal Audiogram? A Systematic Review And Meta-Analysis, Sajana Aryal, Monica Trevino, Hansapani Rodrigo, Srikanta K. Mishra

School of Mathematical & Statistical Sciences Faculty Publications

Understanding the initial signature of noise-induced auditory damage remains a significant priority. Animal models suggest the cochlear base is particularly vulnerable to noise, raising the possibility that early-stage noise exposure could be linked to basal cochlear dysfunction, even when thresholds at 0.25-8 kHz are normal. To investigate this in humans, we conducted a meta-analysis following a systematic review, examining the association between noise exposure and hearing in frequencies from 9 to 20 kHz as a marker for basal cochlear dysfunction. Systematic review and meta-analysis followed PRISMA guidelines and the PICOS framework. Studies on noise exposure and hearing in the 9 …

Postinactivity Exercise Training Improves Sarcopenia Traits In 40–60-Year-Old Women Regardless Of Fortified Milk Supplementation, Joanne Trezise, Ricardo M. Lima, Sally D. Poppitt, Aaron C. Fanning, Amanda Devine, Anthony J. Blazevich

Research outputs 2022 to 2026

Background: The term sarcopenia was introduced to describe the age-related decline in muscle mass, but current definitions also include measures of muscle strength and function. Menopause increases sarcopenia risk and may exacerbate the adverse effects of physical inactivity. Exercise training is a potent stimulus to restore muscle health, and nutritional supplementation can further improve the outcomes. The purposes of this study were to examine the changes in a set of sarcopenia-related phenotypes induced by a 14-day step-reduction period followed by a 12-week exercise training programme, with or without fortified milk supplementation in healthy 40–60-year-old females, and to determine whether menopausal …

Biochar As Additive And Modifier In Bitumen And Asphalt Mixtures, Chathurika Dassanayake, Nuha S. Mashaan

Research outputs 2022 to 2026

Incorporating biochar into pavement materials is a novel and environmentally sustainable approach that aligns with global sustainability goals and advances greener pavement technologies. Studies have shown that biochar significantly enhances the strength, durability, and stability of pavements, while also contributing to sustainability by lowering the carbon footprint associated with traditional construction materials. Additionally, the incorporation of biochar contributes to the sustainability of asphalt engineering by reducing reliance on petroleum-based products and promoting the valorization of biomass. The primary objective of this review is to critically evaluate and synthesize existing research on the use of biochar in bitumen and asphalt mixtures, …

Zinc-Based Amendments And Zn-Solubilizing Beneficial Bacteria Mitigate Lead-Induced Toxicity In Chickpea (Cicer Arietinum L.), Mohammad Shahid, Mohammad Abul Farah, Khalid Mashay Al-Anazi, Leonard Koolman

Research Outputs: 2025-Present

Lead (Pb) is a toxic metal that disrupts plant physiological processes and poses significant human health risks. Fertilizers, nanomaterials, and mineral-solubilizing plant growth-promoting rhizobacteria (PGPR) support phytoremediation as an emerging, eco-friendly strategy for metal detoxification by improving nutrient availability and minimizing metal toxicity in plants. This study explored the interactions of Zn-fertilizer, zinc-oxide nanoparticles (ZnO-NPs), and Zn-solubilizing Enterobacter cloacae (Zns-Ec) in mitigating Pb-induced phytotoxicity in 50, 100, and 150 mgPbkg ⁻¹ soil-stressed chickpea. Under Pb stress. Zn, ZnO-NP and Zns-Ec significantly (p < 0.05) improved root biomass (23.4, 52.3, and 71.4%), chl a (21.2, 26.5, and 39.8%), and carotenoids (26.7, 29.7 and 45.7%) in chickpea subjected to 50 mgPbkg ⁻¹ soil. Zn, ZnO-NP and Zns-Ec interactions reduced lipid peroxidation (LPO), hydrogen peroxide (H ₂O ₂) …

Performance Study Of A Woody Downdraft Gasifier: Numerical Investigation And Experimental Validation, Md Sanowar Hossain, Showmitro Bhowmik, Mujahidul Islam Riad, Md Golam Kibria, Barun K. Das, Sanjay Paul

Research outputs 2022 to 2026

Biomass gasification is an established and widely utilized renewable energy system. The research work aims to develop and construct a downdraft gasifier to investigate gasifier performance. The gasifier’s performance and cold gas efficiency were calculated for three volumetric airflow rates: 7.16 m3/h, 5.97 m3/h, and 4.78 m3/h. The efficiency was found maximum of 69.6% for an airflow rate of 7.16 m3/h. The oxidation zone and neck region of the gasifier reactor had the maximum recorded temperatures of 845 °C and 823 °C for Swietenia macrophylla (SM) and Mangifera indica (MI), respectively. A two-dimensional computational fluid dynamics (CFD) model for a …

Dendrimer Gel Nanoparticles With Dual-Targeting Of Upar And Ribonucleotide Reductase R2 Influence Necrosis, Apoptosis, And Cell Cycle Arrest In Triple-Negative Breast Cancer, Hsin Yin Chuang, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited treatment options due to the absence of estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) receptors. We previously developed highly adaptable polyamidoamine (PAMAM) dendrimer-based gel nanoparticles (GDP-uPA/GTI) with dual-targeting capabilities against urokinase-type plasminogen activator receptor (uPAR) and ribonucleotide reductase R2 (R2) to achieve selective antitumor effects. In this study, we investigated the underlying mechanisms of GDP-uPA/GTI-induced tumor inhibition. In vivo, GDP-uPA/GTI significantly downregulated R2 expression and activated caspase 8 and caspase 3, indicating caspase-dependent apoptosis. Histological evaluation of major organs revealed no observable toxicity. …

Presenting The Inner Triangle Outer Diamond (Itod) Framework Of Educational Ecosystems And Its Applications To The Integration Of Educational Technologies And Innovations., Joshua Owolabi

PCOM Scholarly Works

Educators are leveraging technologies and innovations, including artificial intelligence (AI), to support learners and deliver quality medical education. Many of these initiatives have reportedly yielded positive impacts. There have also been publications and reports highlighting the success of educational technologies (EdTech) and innovations, as well as their potential to not only enhance the outcomes of educational programs but also define the future of medical education and practice. Proponents of EdTech and innovations argue that the significant introduction of EdTech and innovations into programs can enhance learners' experiences, improve programme outcomes, and prepare learners for a future of work and practice …

Evaluating The Efficacy Of Extracorporeal Shockwave Therapy In Postoperative Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Meta-Analysis, Maryam Salimi, Alireza Keshtkar, Seyedarad Mosalamiaghili, Walter Lowe, Aamir Ahmad, Arash Sharafatvaziri

School of Medicine Publications

Background: Recovering from anterior cruciate ligament (ACL) reconstruction can be challenging. While standard rehabilitation helps restore knee function, many patients still face a slow or incomplete recovery. Extracorporeal shockwave therapy (ESWT) has recently gained attention as a potential way to speed up healing and improve outcomes when added to traditional rehab.

Aim: To explore whether combining ESWT with standard postoperative rehabilitation truly leads to better recovery compared with rehab alone.

Methods: A systematic review and meta-analysis were conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, evaluating participant status following ACL reconstruction with standard rehabilitation and without …

Genocidal Accusation, Steven Arrigg Koh

Faculty Scholarship

To accuse of genocide — what does it mean? Genocidal accusation is ubiquitous today, evident more in the public square than in any courtroom. At first glance, such accusation seemingly relies on a central assumption: genocidal accusation is critical to preventing atrocity. This Article argues that this widespread assumption is incomplete, obscuring genocidal accusation’s dual nature. In fact, genocidal accusation encompasses not only laudable atrocity prevention (for example, the Rwandan genocide), but also problematic punitive, carceral discourse that brands the “other” as morally polluted (such as President Putin’s Ukraine invasion). It is thus challenging to evaluate such accusation in the …