Digital Commons Network^™

Climate Change And Population Aging, Anastasia Rhule, Michele Dinman, Natalie Galucia

Harvey A. Friedman Center for Aging

Glaciers are shrinking, river and lake ice is melting earlier, plant and animal habitat ranges are changing, and trees and flowers are blooming earlier. Additionally, longer and more severe heat waves are occurring. Droughts, wildfires, and extreme rainfall are happening at a faster rate than previously predicted by scientists.

Assembling Life From Death: Examining The Archaeological Fauna Of Jupiter Inlet Lighthouse’S Past To Preserve Biodiversity For The Future, Victoria Sherwood

Electronic Theses and Dissertations 2020 - Present

This project utilizes an assemblage of faunal remains from a precontact midden at the Jupiter Inlet Lighthouse archaeological site in northern Palm Beach County, Florida. The assemblage was identified and analyzed through the lenses of resource use and paleoenvironmental changes. The Indigenous groups in the area heavily utilized estuarine resources such as fish and marine turtles. The archaeological assemblage was compared to a modern survey of species present at the site. The species identified in the precontact collection are present in the surrounding area today. The archaeological assemblage matching up with modern species speaks to the success of Loxahatchee River …

Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells For Parkinson's Disease: A Randomized Trial., Mya C Schiess, Jessika Suescun, Juan D Martinez-Lemus, Charles Green, Tia S Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B Satani, Jerome G Saltarrelli, Christopher Adams, Marie-Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M Rodarte, Sean I Savitz, Timothy M Ellmore

Faculty, Staff and Student Publications

Background: Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo-hMSCs) may reduce neuroinflammation and improve motor symptoms.

Objectives: To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo-hMSCs in improving motor symptoms in patients with PD (PwP).

Methods: In this phase 2, randomized, placebo-controlled trial (November 2020-July 2023), mild-to-moderate PwP received either three allo-hMSC infusions, one placebo followed by two allo-hMSC infusions, or three placebo infusions at 18-week intervals. Follow-up lasted 88 weeks. The primary outcome was a >70% posterior probability (PP) of a difference in the proportion of participants …

Prone Percutaneous Jungbluth For Reduction Of Irreducible Posterior Pelvic Ring Injuries: A Technical Trick, Joseph M Radley, Jonathan A Copp, Daniel S Gloekler, Jonathan G Eastman

Faculty, Staff and Student Publications

Unstable pelvic ring injuries represent a challenge due to the complex anatomy. Further, surgical access to the pelvic ring is altered by patient positioning in the supine versus prone position. Certain injury patterns present with the posterior pelvis in a fixed displaced position. These injuries can be exceedingly challenging to reduce from a supine position. In the prone position, these injuries can be reduced more directly with an open approach, but this is associated with wound healing complications. The technical trick herein demonstrated a successful technique utilizing a large Jungbluth clamp percutaneously applied to the posterior superior iliac spines with …

Efficacy Of Platelet Rich Plasma Versus Placebo For Improvement In Olfactory Function In Adults With Olfactory Dysfunction: A Systematic Review And Meta-Analysis, Ali B Jafar, Ghabrielle Almeida, Fatima Al Mousawi, Eric Delgado Rendon, Amber U Luong

Faculty, Staff and Student Publications

Background: Olfactory dysfunction significantly impairs quality of life. Conventional treatments such as corticosteroids and olfactory training offer limited and inconsistent efficacy. Platelet-rich plasma (PRP), a biologically active agent, has shown potential regenerative effects in olfactory neuroepithelium. This study systematically evaluates the efficacy of PRP compared to placebo in improving olfactory function.

Methods: A systematic review and meta-analysis was conducted according to PRISMA guidelines and was registered in PROSPERO (CRD 420251045079). The databases searched included PubMed, Scopus, Embase, Central, and Web of Science. Seven studies (four RCTs, three non-RCTs) involving 789 patients were included. Subjective and objective outcomes were extracted and …

Whipple Disease Initial Presentation As Supraclavicular Lymphadenopathy In A Patient With Rheumatoid Arthritis: A Diagnostic Challenge, Sara E Amin, Swati Gite, Audrey Wanger, Violeta Chavez, Jacob Armstrong, Beenu Thakral, Patricia Navarro, Jennifer Makhoul, Amer Wahed, Navneet Narula, Karan Saluja

Faculty, Staff and Student Publications

Whipple disease is a rare systemic disease caused by Tropheryma whipplei. It can present with a wide range of nonspecific symptoms that might overlap with underlying medical conditions, posing a diagnostic challenge. We present a 61-year-old man with a past medical history of rheumatoid arthritis and chronic inflammatory demyelinating polyneuropathy, who presented with persistent leukocytosis and supraclavicular lymphadenopathy. A positron emission tomography scan revealed hypermetabolic activity in the supraclavicular, abdominal, and pelvic lymph nodes along with a myocardial hypermetabolic lesion, concerning a lymphoproliferative disorder versus sarcoidosis. A supraclavicular lymph node excisional biopsy revealed complete architectural effacement by a diffuse foamy …

Combining Pirfenidone With Mycophenolate Mofetil For Systemic Sclerosis-Related Interstitial Lung Disease (Scleroderma Lung Study Iii): An Investigator-Initiated, Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial, Dinesh Khanna, Cathie Spino, Donald P Tashkin, Elana J Bernstein, Jonathan Goldin, Eric C Kleerup, Airi Harui, Grace Ibrahim, Grace Hyun J Kim, Suiyuan Huang, Richard Mclain, Yi-Hsuan Tu, Vivek Nagaraja, Richard M Silver, Virginia D Steen, S Samuel Weigt, Joyce S Lee, Aryeh Fischer, Mary Beth Scholand, Jessica K Gordon, Paul F Dellaripa, Ivan O Rosas, Gary M Hunninghake, Marcin A Trojanowski, Robert W Simms, Jane E Dematte, Vivien M Hsu, Robyn T Domsic, Ganesh Raghu, Maureen D Mayes, Ryan D Boente, Michael D Roth

Faculty, Staff and Student Publications

Objective: Mycophenolate mofetil (MMF) can stabilize or improve lung function in systemic sclerosis-related interstitial lung disease (SSc-ILD). We hypothesized that combining MMF with pirfenidone (PFD) would produce a significantly more rapid and/or greater improvement in lung function.

Methods: A randomized (1:1), double-blind, placebo (PLA)-controlled phase 2 trial was conducted in SSc-ILD in which patients received PFD or PLA (801 mg three times daily) along with MMF (1,500 mg twice daily) for 18 months. The primary outcome was change in percent predicted forced vital capacity (FVC-%). Linear mixed-effects models assessed treatment differences in a modified intention-to-treat population.

Results: Only fifty-one of …

Revisiting Soluble Guanylate Cyclase Pharmacology: Additive Potential Of Stimulators And Activators, Alexandra Petraina, Mahmoud H Elbatreek, Christopher T Neullens, Theodora Saridaki, Vu Thao-Vi Dao, Rebecca D Szepanowski, Emil Martin, Wolfgang Sippl, Ana I Casas, Harald H H W Schmidt

Faculty, Staff and Student Publications

Nitric oxide (NO) is a key gasotransmitter that binds to soluble guanylate cyclase (sGC), thereby stimulating cGMP production. Under disease conditions, reactive oxygen species disrupt this signaling by either: (1) scavenging NO, or (2) promoting heme-free, NO-insensitive apo-sGC due to impaired heme incorporation or oxidative damage. To counteract these conditions, two pharmacological approaches have emerged: sGC stimulators, which allosterically enhance sGC sensitivity to low NO levels; and sGC activators, which directly activate apo-sGC (heme-free sGC) by binding to its empty heme pocket, inducing a conformation that mimics NO-bound sGC. Thus, sGC stimulators are thought to target only sGC. Instead, we …

Utilizing Functional Neuroimaging To Study Early Language Development, Halie A Olson, Trevor K M Day, Kelly J Hiersche, Brittany L Manning, Holly Bradley, Soujin Choi, Gavkhar Abdurokhmonova, Sarah A Mccormick, Amy L Conrad, Dustin Scheinost, Kelly A Vaughn

Faculty, Staff and Student Publications

Language develops rapidly over the infant and toddler period and has been a key area of research within the field of developmental cognitive neuroscience. Understanding the neural basis of early language development may help us predict delays or disorders, recommend early interventions, and provide a deeper mechanistic understanding of how the brain supports language learning. While the ontogeny of many cognitive functions can be studied in animal models, language development can only be studied in human children. Thus, functional neuroimaging is critical for uncovering the neural basis of language in early development. The purpose of this review is to take …

“Festivity Without Feast”: Autonomy, Prosperity, Mutuality And Inequality In A Mentawai Village, Darmanto Darmanto

Antropologi Indonesia

Among the Mentawai, autonomy, prosperity, and mutuality are core values that foster their egalitarian ethos. In the last few decades, they have reconfigured these values in their quest for equality with outsiders who have consistently looked down upon them. The state encourages and facilitates their pursuit by establishing a centralised village, implementing development projects, and promoting engagement in commodity production. These processes direct productive work results towards household livelihoods, legitimising wealth accumulation and sidelining sharing practices. In seeking equality with outsiders, the realisation of autonomy and productivity increasingly leads to internal inequality, which is the antithesis of their egalitarian quest …

Source-Specific Nitrate Intake And Incident Dementia In The Danish Diet, Cancer And Health Study, Catherine P. Bondonno, Pratik Pokharel, Dorit Wielandt Erichsen, Liezhou Zhong, Jörg Schullehner, Cecilie Kyrø, Kirsten Frederiksen, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Lauren C. Blekkenhorst, Stephanie R. Rainey-Smith, Samantha L. Gardener, Torben Sigsgaard, Ole Raaschou-Nielsen, Anne Tjønneland, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Nicola P. Bondonno

Research outputs 2022 to 2026

Introduction: Dietary nitrate, through conversion to nitric oxide, which supports vascular and nervous system function, may lower dementia risk but may also form neurodegenerative N-nitrosamines, depending on the nitrate source. Methods: We investigated associations between source-specific nitrate and nitrite intake and incident and early-onset dementia (< 65 years) in 54,804 dementia-free participants from the Danish Diet, Cancer and Health Cohort Study over ∼27 years. Nitrate and nitrite intakes were derived from food frequency questionnaires and nitrate and nitrite databases. Results: Higher plant-sourced nitrate intake was non-linearly associated with lower rates of incident dementia (fifth vs first quintile hazard ratio 95% confidence interval: 0.90 [0.83, 0.98]), while increased risk was seen for higher intakes of animal-sourced, additive-permitted meat-sourced, and tap water-sourced nitrate. Similar associations were seen for source-specific nitrite intake and were more pronounced for early-onset dementia. No clear effect modification was observed. Discussion: These findings highlight the importance of nitrate source in dementia risk and warrant further investigation. Highlights: Plant nitrate is associated with a lower risk of incident and early-onset dementia. Animal and tap water nitrate are associated with an increased risk of dementia. Encouraging consumption of plant-based nitrate sources may lower risk of dementia.

Exercise Medicine As Adjunct Therapy During Radiation For Cancer Of The Prostate To Improve Treatment Efficacy – Protocol For The Eradicate Study: A Phase Ii Randomised Controlled Trial, Oliver Schumacher, Robert U. Newton, Colin Tang, Raphael Chee, Sjoerd B. Vos, Ronny S. Low, David Joseph, Dennis R. Taaffe, Daniel A. Galvão

Research outputs 2022 to 2026

Background: Tumour hypoxia resulting from inadequate perfusion is common in many solid tumours, including prostate cancer, and constitutes a major limiting factor in radiation therapy that contributes to treatment resistance. Emerging research in preclinical animal models indicates that exercise has the potential to enhance the efficacy of cancer treatment by modulating tumour perfusion and reducing hypoxia; however, evidence from randomised controlled trials is currently lacking. The ‘Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE’ (ERADICATE) study is designed to investigate the impact of exercise on treatment response, tumour physiology, and adverse effects of treatment in prostate …

Parasite Sedimentary Dna Reveals Fish Introduction Into A European High-Mountain Lake By The Seventh Century, Elena Fagín, Marisol Felip, Anton Brancelj, Pere Masqué, Jordi Catalan

Research outputs 2022 to 2026

High-mountain lakes were historically fishless due to natural barriers, but human introductions have led to widespread fish presence. Although particularly intensive during the last decades, historical documents indicate introductions in European high mountains already during the 14th and 15th centuries, but they could have occurred before, provided the intensive land use of the high mountain had started earlier. We used ancient environmental DNA from lake sediments (sedDNA) to investigate this hypothesis. Fish ectoparasites from various clades were identified using the 18S rRNA gene in the sediment record of a deep, high-mountain Pyrenean lake, with Ichthyobodo (Kinetoplastea) being of particular interest …

Population Genomics Of Pacific Herring Spawning Aggregations In The Eastern Bering Sea, Sydney A. Almgren

Fisheries

Pacific herring (Clupea pallasii) is a critical forage fish to the marine environment, economy, and culture of Alaska. However, despite the importance of Pacific herring in Alaska and throughout the North Pacific, knowledge gaps exist for foundational genomic characteristics of the species, including genetic population structure and the basis of genetic sex determination. In this thesis, I addressed these knowledge gaps using low coverage, whole genome sequencing. I assessed population structure and genetic diversity across seven sampling sites and found three genetic populations: Unalaska, the farthest south sampling location, Kotzebue, the farthest north, and a third group unassociated with geographic …

Addressing Critiques Refines Global Estimates Of Reforestation Potential For Climate Change Mitigation, Kurt A. Fesenmeyer, Erin E. Poor, Drew E. Terasaki Hart, Joseph W. Veldman, Forrest Fleischman, Pooja Choksi, Sally Archibald, Mohammed Armani, Matthew E. Fagan, Evan C. Fricke, César Terrer, Natalia Hasler, Christopher A. Williams, Peter W. Ellis, Susan Cook-Patton

Geography

Reforestation is a prominent climate change mitigation strategy, but available global maps of reforestation potential are widely criticized and highly variable, which limits their ability to provide robust estimates of both the locations and total area of opportunity. Here we develop global maps that address common critiques, build on a review of 89 reforestation maps created at multiple scales, and present eight reforestation scenarios with varying objectives, including providing ecosystem services, minimizing social conflicts, and delivering government policies. Across scenarios, we find up to 195 Mha (million hectares) are available (2225 TgCO2e (teragrams of carbon dioxide equivalent) per year total …

Real-Time Malaria Detection In The Amazon Rainforest Via Drone-Collected Edna And Portable Qpcr, Yin Cheong Aden Ip, Luca Montemartini, Jia Jin Marc Chang, Andrea Desiderato, Nicolás D. Franco-Sierra, Christian Geckeler, Mailyn Adriana Gonzalez Herrera, Michele Gregorini, Meret Jucker, Steffen Kirchgeorg, Martina Lüthi, Elvira Mächler, Frederik Bendix Thostrup, Guglielmo Murari, Marina Mura, Paola Pulido-Santacruz, Florencia Sangermano, Tobias Schindler, Claus Melvad, Stefano Mintchev, Kristy Deiner

Geography

Zoonotic malaria risk at human-wildlife-environment interfaces requires surveillance that integrates signals from reservoirs, vectors and the environment. We coupled a drone-based environmental DNA (eDNA) canopy swabbing approach with portable quantitative PCR (qPCR) to detect Plasmodium DNA in situ during a 24-h field exercise in the Amazon rainforest. Drone-lowered sterile swabs into the canopy, which were then extracted and subjected to a multiplex pan-Plasmodium assay targeting five human-infecting Plasmodium species (limit of detection 0.2 parasites μL−1). Of 12 samples (10 canopy swabs, 2 field blanks; 13 total runs including repeats), one canopy swab amplified in duplicate (Ct = 28.7 and 29.23), …

Charity Begins With Zoning Reforms, Mark D. Bjelland

University Faculty Publications and Creative Works

When my family moved to Michigan over a decade ago, we were looking for something more than a three-bedroom house in our price range. We wanted a place of beauty, refreshment, and welcome for our children and guests. As newcomers to the state, we took the location seriously. Our previous house lost value due to its small-town setting, so we worried about future property values. As an urban geographer, I mapped changes in demographics and housing prices and created bike and bus travel-time maps from work and schools.

Effect Of The Debrief Component Of The Experiential Learning Model On Attitudes Of 4-H Camp Participants, Creenna Bocksnick

Graduate Theses and Dissertations

This study examined the effect of the debrief/reflection component of the Experiential Learning Model on attitudes of 5 - 12-year-olds (n = 58) and 13 - 15-year-old (n = 22) campers attending a three-day camp session during summer 2022. The 5- 12-year-old campers engaged in canoeing/paddleboarding, archery, rock climbing, leather crafting, and fishing. The 13 - 15-year-old campers engaged in canoeing/paddleboarding, rock climbing/giants ladder, high ropes course, and noodle boat races. Both groups of campers were randomly assigned in approximately equal numbers to either a no-debrief (control) or de-brief (treatment) group. For each camp activity the control group completed a …

Work-Related Pathology At Tell El-Amarna: The Physical Cost Of Building A New Capital City In The New Kingdom, Egypt, Heidi Suzanne Davis

Graduate Theses and Dissertations

This dissertation examines patterns of work-related indicators of physical stress in a skeletal sample from the non-elite adult population of the South Tombs Cemetery (STC) of Amarna, Egypt. Assessing work-related pathology using an integrative model of physical stress, this study considers the interactions of demographic parameters of age, sex, and injury recurrence, along with archaeological and documentary data to provide a biocultural contextual approach to physical stress in this population. The STC sample is compared to other samples from Egyptian and Nubian sites as well as historical samples believed to be under high physical demands and stressful conditions. The STC …

Consequences Of Secondary Traumatic Stress On Individuals Without Formal Psychological Training Working With Trauma-Exposed Children, Juan F. Valdez

Electronic Theses and Dissertations

Literature has suggested that secondary traumatic stress could cause various adverse effects for individuals working with trauma-exposed populations. However, direct care workers performing in shelters designed to serve unaccompanied immigrant children are faced with the task of caring for these minors who may have been exposed to trauma in their home countries, while traveling to the United States, or after arriving in the country. This qualitative case study was conducted to understand and describe the experiences of 15 current employees and five ex-employees who have worked with unaccompanied children for at least a year. These individuals participated in in-depth personal …

Environmental Beliefs Among Evangelical Leadership, Jeffrey Stark

Dissertations

There has been consensus among climate scientists for over a decade about the reality of human caused climate change. Even with this consensus, the public understanding of this issue remains divided based on factors generally unrelated to the science. Evangelical Protestants are one group which consistently polls as more skeptical of climate change. This is true not only when compared to the general population but also when compared to other religious demographics. Most large-scale surveys of evangelicals assume the demographic to be a monolith and do not attempt to break the demographic down further. In this mixed methods study, we …

Judicial Ethics, The Supreme Court, And The Rule Of Law, Charles G. Geyh

Articles by Maurer Faculty

This Essay begins with a short history of judicial ethics regulation in the United States, ending with the adoption of codes of conduct by every state and federal judicial system except the Supreme Court of the United States. It then turns to a series of ethics controversies encircling the Supreme Court and its justices, which culminated in the Supreme Court adopting a Code of Conduct in 2023. Tapping into the social science literature, it argues that for codes to improve the ethical climate of an institution they must encourage psychological ownership of and “buy-in” to a code by those subject …

Administration Plan For Use Of Hippotherapy In Occupational Therapy, Ryanna Blake

Occupational Therapy Doctoral Capstones

The intention of this capstone experience was to promote the use of hippotherapy as a treatment strategy in the occupational therapy profession from an administrative and educational standpoint. Hundreds of research studies have indicated the effectiveness of hippotherapy for a variety of ages and diagnoses. However, there are still barriers that prevent hippotherapy from being more accessible and well-known, both by practitioners, client families, and the community. The project was executed at a startup psychotherapy clinic preparing to offer equine-assisted services in Tulsa, Oklahoma. The mutually beneficial partnership led to the creation of a generalized administration plan for an occupational …

Safe-Sora: Safe Text-To-Video Generation Via Graphical Watermarking, Zihan Su, Xuerui Qiu, Hongbin Xu, Tangyu Jiang, Jun-Hao Zhuang, Chun Yuan, Ming Li, Shengfeng He, Fei Yu

Research Collection School Of Computing and Information Systems

The explosive growth of generative video models has amplified the demand for reliable copyright preservation of AI-generated content. Despite its popularity in image synthesis, invisible generative watermarking remains largely underexplored in video generation. To address this gap, we propose Safe-Sora, the first framework to embed graphical watermarks directly into the video generation process. Motivated by the observation that watermarking performance is closely tied to the visual similarity between the watermark and cover content, we introduce a hierarchical coarse-to-fine adaptive matching mechanism. Specifically, the watermark image is divided into patches, each assigned to the most visually similar video frame, and further …

Stableguard: Towards Unified Copyright Protection And Tamper Localization In Latent Diffusion Models, Haoxin Yang, Bangzhen Liu, Xuemiao Xu, Cheng Xu, Yuyang Yu, Zikai Huang, Yi Wang, Shengfeng He

Research Collection School Of Computing and Information Systems

The advancement of diffusion models has enhanced the realism of AI-generated content but also raised concerns about misuse, necessitating robust copyright protection and tampering localization. Although recent methods have made progress toward unified solutions, their reliance on post hoc processing introduces considerable application inconvenience and compromises forensic reliability. We propose StableGuard, a novel framework that seamlessly integrates a binary watermark into the diffusion generation process, ensuring copyright protection and tampering localization in Latent Diffusion Models through an end-to-end design. We develop a Multiplexing Watermark VAE (MPW-VAE) by equipping a pretrained Variational Autoencoder (VAE) with a lightweight latent residual-based adapter, enabling …

2025 December, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2025.

Three Forks, Virginia Van Enckevort

Theses

Three Forks is a thesis drama series about a 19th-century woman sent West to live with her estranged family in Muscogee, a lawless town where justice bends to power and survival means learning the game — or being buried by it. As we follow our lead, Eleanor Davis, out West and eventually her settlement into town, we gain a look into her new world, one where tribal council contend with encroaching U.S. jurisdiction and where settlers, freedmen, and railroad men jostle for influence in a town on the brink of statehood. The many fabled stories and myths about the West …

Practice?, Pei Chen

Theses

3D animation is a combination of art and technique. Art serves to convey your perspective, express beauty, tell stories, and more. However, to accomplish these goals, we need solid technical support. Only by paying attention to both, can we achieve excellent results. The title of this film is “Practice?”, which is a deliberate pun. On one hand, "practice" refers to the martial arts training sequences of the character, during which his master provides guidance, intervenes in his movements, and progressively increases the difficulty. On the other hand, "practice" also symbolizes my own artistic and technical experimentation—exploring and refining skills in …

Whisper Wall: Transforming Global Superstitions Into A Unified, Sound-Reactive Immersive Experience, Hardika Nitin Patil

Theses

Superstitions, often dismissed as irrational in today’s data-driven world, remain deeply rooted in human culture and behavior, offering meaning and a sense of control amid uncertainty. Whisper Wall is an immersive, sound-reactive installation that invites audiences to explore these enduring beliefs through whispered audio narration and symbolic, shadow-inspired visual storytelling. This project re-engages audiences with rich, cross-cultural superstitions, encouraging reflection beyond skepticism to thoughtfully examine their origins and significance. Blending visual communication, motion design, sound, and interaction, Whisper Wall creates a multisensory experience where users activate intimate stories via interactive elements—whisper-like audio delivered through red paper cups coupled with minimalist, …

Lanthorn, Vol. 60, No. 08, December 1, 2025, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.