Digital Commons Network^™

Evergreening's Empirical Chasm, Erika Lietzan

Faculty Publications

For more than two decades, policymakers have been told that pharmaceutical innovators companies engage in a practice that is called, disparagingly, “evergreening.” The basic idea is that companies introduce new versions of their drugs that have later expiring patents or regulatory exclusivity. This way, the claim goes, the companies effectively block generic entry for years or decades longer than Congress intended and than is socially desirable. Initially these claims were supported by poorly researched anecdotes. In the last decade, some scholars and advocacy organizations have published papers that purport to provide empirical support for the “evergreening” accusation. But these empirical …

Exploring Motivation In Visual Arts: Middle School Art Teachers' Perspectives, Eva V. Coker

Graduate Research Theses & Dissertations

The purpose of this study was to explore pedagogical strategies and curriculum (media and art projects) that 6th through 8th grade middle school art teachers use to motivate students to participate in the visual arts. Specifically, it examined the instructional strategies, media choices, and art projects that teachers perceived as inspirational and motivational for middle school students. This qualitative study included data from 17 middle school art teachers, collected through interviews, video-recorded nonverbal communication cues, and teacher-submitted artifacts. The findings revealed a range of instructional strategies, media and curricular practices, and flow and affective experiences that teachers believed supported student …

Exploring Approaches To Address Racial Discrimination, Stigma, And Provider Communication In Sickle Cell Disease Pain Management Through Interprofessional Education And Collaboration, Ronisha Edwards-Elliott

Graduate Research Theses & Dissertations

This dissertation presents research across three publishable manuscripts that investigate why structural and systemic racism persist among patients with sickle cell disease (SCD) seeking pain management, and how interprofessional collaboration and education can help reduce disparities through shared learning, accountability, and standardized care (Chapters Two through Four). A scoping review identifies current interventions and strategies aimed at sharing the pain experiences and feelings of being unheard by SCD patients (Chapter Two). Findings of the scoping review revealed that although interventions and strategies exist and have been tested, the lack of implementation or buy-in from healthcare professionals has allowed racial discrimination …

Comprehensive Characterization Of Chronic Midazolam Exposure On Neonates And Long-Term Neurodevelopment, Nghi M. Nguyen, Pranavi Athota, Adrian Flores, Andrew Trease, Daniel Meyer, Vamsi K. Singu, Chandan Krishnamoorthy, Victoria L. Schaal, Reeyan Bhakat, Kunal Sualy, Sathish Kumar Natarajan, Kelly L. Stauch, Sowmya V. Yelamanchili, Gurudutt Pendyala

Journal Articles: Anesthesiology

Approximately 1 in 10 U.S. newborns are born preterm (< 37 weeks of gestation), facing risks of low birth weight, respiratory and birth deficits often requiring surgery, mechanical ventilation, and prolonged sedation. Such long-term exposure to sedatives in these babies can potentially pose neurodevelopmental risks and can further impact changes later in life. The present study focused on midazolam (MDZ), a benzodiazepine class drug commonly used as sedative in the neonatal intensive care unit (NICU). Using a robust preclinical rodent model mimicking chronic MDZ exposure, we did a comprehensive characterization on the phenotypic, molecular, biochemical, and behavioral outcomes in these exposed neonates across key developmental milestones. Our findings indicate that long-term MDZ exposure during the neonatal period negatively affects physical attributes in early childhood. While adult bodyweights between control and MDZ-exposed rats remain comparable, the MDZ rats exhibit accelerated and robust weight gain, potentially indicating a predisposition for binge eating behavior. Additionally, dopamine release in MDZ-exposed rats is markedly reduced in adulthood. Elevated levels of pro-inflammatory cytokines and growth factors in the brain during adulthood suggest a shift in development due to early MDZ exposure. Further, trends of heightened anxiety-like behavior and reduced social interaction during early adolescence compared to other stages were observed. Collectively, our study provides a comprehensive assessment of how long-term MDZ exposure during neonatal stages impacts outcomes throughout life, laying the foundation for understanding mechanisms that contribute to neurodevelopmental complications associated with long-term MDZ use in neonates.

Area Of Effect The History And Effects Of Linguistic Choices Made In The Final Fantasy Franchise, Camille Mcdermott

Theses and Dissertations

The Final Fantasy franchise, a seminal role-playing game (RPG) series, has captivated a global audience since its inception in 1987. This thesis, titled "Area of Effect: The History and Effects of Linguistic Choices Made in the Final Fantasy Franchise," explores the intricate use of language that has shaped the series' identity and influenced its worldwide fanbase. The linguistic landscape of Final Fantasy is as diverse and dynamic as its fantastical worlds, evolving from simple text boxes to fully voiced narratives. This study examines the historical context and evolving linguistic choices throughout the series, highlighting how these decisions enrich the gaming …

The Rise Of Israeli Far-Right Politics: A Queer Feminist Analysis, Sa'ed Atshan, K. Galor

Peace & Conflict Studies Faculty Works

No abstract provided.

Evaluating The Condition Of Age-0 Burbot In Relation To Diet, Cian Verbridge

Journal of Earth and Life Science

Burbot are becoming more and more popular for angling and aquaculture. However, populations have been declining across the world. Very little information is available about their early life and their interactions in the ecosystem due to challenges in sampling. Condition estimates and diet metrics were used to better understand the status of burbot in Lake Bemidji. Using backpack electrofishing, 45 young of the year burbot were collected. The lengths ranged from 86 to 146 mm and the wet weights ranged from 4.29 to 24.36 g. The stomach contents were removed and stored in ethanol for later analysis. The burbot were …

Modeling Wild Rice Bed Health: A Dual Metric Approach For Bed Strength And Invasive Impact, Seth Sisneros-Martinez

Journal of Earth and Life Science

Wild rice (mannoomin; Zizania palustris) is an aquatic grain that grows in slow-moving rivers and shallow bays throughout northern Minnesota. In Headquarters Bay on Leech Lake, wild rice has served as a cultural staple for Indigenous communities for centuries. However, its population has declined in recent years due to multiple environmental issues. One potential contributor is Eurasian watermilfoil (Myriophyllum spicatum; EWM), an invasive species that forms dense mats capable of outcompeting native aquatic vegetation, including wild rice. EWM was first recorded on the southern shoreline of Leech Lake in 2005 and has since become widespread. This study …

A Rare Case Of Brucellosis Relapse, Rabia Mahfooz, Grant Patterson, Annmary Behanan, Babivigasan Gunasegaran

Gulf Coast Division GME Research Day 2025

No abstract provided.

Lady Macbeth's Maternity And Morality, Lauren Johnson

Theses and Dissertations

This thesis explores the ways in which adaptations of Lady Macbeth from the seventeenth century to modern day have functioned to vilify or redeem Lady Macbeth based on her connection with her maternity as well as on the contextual, cultural, and political opinions surrounding both a woman’s place in society and the importance of maternity. This thesis examines William D’Avenant’s 1674 stage adaptation of Macbeth, Han Tae-Sook’s 1998 stage adaptation Lady Macbeth, and Lisa Klein’s 2009 novel adaptation Lady Macbeth’s Daughter to capture a range of cultures and the evolution of the character.

“My Pain Was Never More Valuable Than His Potential”: A Rhetorical Thematic Analysis Of Gaslighting Within Sexual Abuse Cases, Makayla Roller

Theses and Dissertations

This thesis examines gaslighting within three prominent sexual abuse cases—Harvey Weinstein, Matt Lauer, and Larry Nassar—uncovered during the #MeToo movement, to better understand the rhetorical function of gaslighting. Using a combination of rhetorical thematic analysis, critical discourse analysis, a feminist lens, and a gaslighting schema, this study identifies the rhetorical tactics, gendered discourse, and power-laden discourse deployed to gaslight victims and the public. I argue that gaslighting must be examined through a rhetorical lens, as discourse is the mechanism through which gaslighting operates, shaping perceptions of truth, credibility, and power. By highlighting how language is weaponized to deny, distort, and …

“The New Force”: The Rhetoric Behind Nana Kwame Bediako's Masked Campaign, Emmanuella Ama Gyamfi

Theses and Dissertations

This study examines Nana Kwame Bediako’s unconventional masked campaign in Ghana’s 2024 presidential election using Norman Fairclough’s three- dimensional Critical Discourse Analysis (CDA). The research analyzes how Bediako employed anonymity through a masked persona on billboards before revealing his identity as a strategic political innovation. The study examines two key moments: Bediako’s unveiling speech after the government of Ghana cancelled his planned convention event, and his subsequent televised interview with JoyNews. The analysis reveals how the mask functioned as a complex symbol that generated public curiosity, challenged Ghana’s NPP- NDC political duopoly, and connected pan-African identity. Through the textual, discursive …

Embracing Digital Disruption In Tanzania: Insights From Mwananchi Communications Ltd's Print-To-Digital Multimedia Journey, Absalom Norman Kibanda

Executive Masters in Media Leadership and Innovation

This capstone study investigates the profound impact of digital transformation on print media, employing Mwananchi Communications Ltd (MCL) in Tanzania as a case study, elucidating the intricate fusion of cultural transformation and strategic shifts in response to this disruption. With an in-depth exploration of theoretical frameworks like Networked Communication Theory and Media Convergence Theory, this study underscores the evolution of MCL's culture and the paradigm shift in the mindset of its staff and readers since the company's strategic embrace of multimedia strategies. MCL's transformative journey, characterized by the adoption of innovative multimedia platforms, including a website, paywall approaches, subscription models, …

What Do They Love? A Study Of Digital Media Consumption By Young University Audiences In Uganda, Allan Chekwech

Executive Masters in Media Leadership and Innovation

The proliferation of computers, smartphones, the Internet, social media, and streaming platforms has led to a surge in digital media consumption. Young audiences, especially those aged between 18 and 34, are increasingly turning to digital platforms for entertainment, information, and social interaction, much to the disadvantage of traditional media platforms such as the newspaper, radio and television. As a result, many media players are concerned about what young people consume, especially if they follow any news. Consequently, the desire to understand their news consumption habits on these digital platforms is paramount. Using a quantitative approach, this study got responses from …

Saving The Arctic: Learning Through Animals And Art, Sara A. Wieschhorster, Andrea J. Goldfarb, Linda Walters Dr

High Impact Practices Student Showcase Fall 2025

The Arctic is one of the most fragile ecosystems on Earth, and protecting it is vital for our planet’s future. For our service‑learning project, we partnered with Ms. Snow and Wedgefield Elementary to engage her first‑grade classroom in learning about Arctic animals and their adaptations. We introduced a variety of species, highlighting unique adaptations, and reinforced this knowledge through a craft activity where students created walrus masks to take home. Beyond animal adaptations, we discussed habitat fragmentation and encouraged students to take action against environmental threats by planting trees, recycling, and staying informed. Our goal was to spark environmental awareness …

Budget For The Fiscal Year Ending June 30, 2025, University Of Arkansas, Fayetteville

Budget for the Fiscal Year

No abstract provided.

[In] Transformation President's Impact Report, Bryant University

Bryant University Communications and Press

The 2025 President's Impact Report highlights Bryant University’s continued excellence in higher education, from its top-tier rankings and dynamic campus life to its hands-on learning experiences and strategic partnerships. Strong financial foundations and visionary leadership solidify its position as an innovative and forward-thinking institution. IN the Lead Bryant's international rankings and thought leadership in prestigious publications reinforce its position as a leader in higher education.

The Political Question Of Public Lands, Ryan A. Semerad

Wyoming Law Review

The Property Clause of Article IV of the United States Constitution provides: “Congress shall have Power to dispose of and make all needful Rules and Regulations respecting the Territory or other Property belonging to the United States.” Thus, among other things, the Constitution assigns the disposal of federally owned lands to Congress alone. That means the other branches of the federal government, including the courts, have no jurisdiction to exercise this power or to compel Congress to use it. Put another way, when Congress does not dispose of public lands through sale or transfer, that inaction is not subject to …

Force Of Nature (2024) By Ann E. Burg, Maughn Rollins Gregory

Middle Grades Books

Rachel Carson launched the modern environmental movement with books that combined detailed observations of the natural world, scientific research, and philosophical reflection on humanity’s relationship with nature — all conveyed in poetic language. Ann E. Burg’s fictional biography-in-verse Force of Nature shows how these habits of observation, questioning, reflection, and expression began in Carson’s childhood, and invites readers to follow her lines of inquiry. Can we provide for human well-being without sacrificing the well-being of non-human life? Can we provide for the well-being of certain human populations without sacrificing the well-being of others? Can we indulge our wonder about, and …

Eyes And The Impossible (2023) By David Eggers, Peter Shea

Middle Grades Books

The Eyes and the Impossible joins the genre of talking animal stories, deepening that genre, suggesting new ways that the animal point of view could help humans understand their strivings for limitlessness and their temptations to retreat into a safe world. The dog narrator, Johannes and his animal friends and colleagues are all open to the world beyond their cozy home; they are willing to take great risks to learn something new. The book models the adventure of learning and growing up, without sacrificing the power of a great story.

René Dubos: An Annotated Bibliography, Carol L. Moberg

René Dubos: An Annotated Bibliography

René Dubos (1901–1982), a prominent 20th century scientist, humanist, and philosopher, was a prolific author. Affiliated for more than 50 years with The Rockefeller Institute for Medical Research/The Rockefeller University, his studies ranged from antibiotics and the role of bacteria in human diseases to formulating broad ecological and environmental questions affecting human health and disease. His seminal writings explore a lifelong belief that a living organism—whether microbe, human being, society, or the Earth itself—could be understood only through its relationships with everything else.

This comprehensive bibliography of more than a thousand works by René Dubos includes brief annotations for each …

Germline Genetic Modulator Of Cancer Metastasis, Wenbin Mei

Student Theses and Dissertations

Metastasis formation is the most critical determinant of cancer survival outcome. Identifying patients at risk for metastatic relapse facilitates clinical decision and the use of appropriate adjuvant therapy, thus having a profound impact on patient survival. A central dogma in cancer is that during tumorigenesis, cancer cells acquire somatic mutations that regulate metastatic likelihood during evolution of the primary tumor. However, despite extensive tumor sequencing efforts, such causal somatic metastasis driver mutations have not been found, limiting the discovery of biomarkers, mechanisms and drug targets of cancer metastasis. In this thesis, I report a germline genetic driver of breast cancer …

Sequential Transcriptional Gates In The Thalamo-Cortical Circuit Coordinate Memory Consolidation, Andrea Terceros

Student Theses and Dissertations

How are memories maintained over weeks, months or even years? The molecular mechanisms that enable memories to persist over long time-scales remain poorly understood. As a point of entry, recent work in our lab revealed that beyond the hippocampus, where memories are initially formed over hours/days, the thalamo-cortical circuit is important for the gradual stabilization of memories over weeks/months. In this thesis, I aimed to reveal the molecular mechanisms operating in the thalamo-cortical circuit that may be responsible for extending memory time-scales. I began by developing a virtual reality-based behavioral paradigm where, by varying the frequency of learned associations, mice …

The Evolution Of Ribosome Assembly: Making Ribosomes In The Mitochondria, Chloe Burnside

Student Theses and Dissertations

Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the mitochondrial genome that are assembled into oxidative phosphorylation complexes. As such, the biogenesis of mitoribosomes is essential for ATP production and cellular metabolism. Despite significant progress in elucidating the structures of mature mitoribosomes, a comprehensive understanding of their assembly pathways remains elusive. This thesis presents the first structural characterization of assembly intermediates of the mitochondrial small subunit (mtSSU) in eukaryotes. To gain mechanistic insight into the process of SSU assembly in the mitochondria, I set out to enrich and characterize intermediates of SSU assembly in the mitochondria of S. cerevisiae. By employing …

The Spatiotemporal Dynamics Of Nomadic Behavior In The Clonal Raider Ant, Ooceraea Biroi, Dennis Octavio Melendez

Student Theses and Dissertations

Nest relocation is integral to the lives of many social insects. Army ants have taken this behavior to the extreme, with many species relocating an entire colony of over 100,000 ants plus brood almost daily. Despite its prevalence, the question of how army ant colonies emigrate has been debated for many decades, and still awaits a definitive answer because conducting well-controlled field experiments with their massive and aggressive colonies is challenging. In ants, the Dorylinae subfamily has given rise to most known army ants. Therefore, performing experiments in non-army ant dorylines that can be maintained in a laboratory setting presents …

Serotonin-Mediated Sickness Behavior, Audrey Harnagel

Student Theses and Dissertations

Serotonin is an ancient and powerful neuromodulator that regulates diverse processes from fundamental physiology to complex emotions. Due to the many functions of serotonin distributed throughout the body and brain, governing principles of serotonin signaling have remained elusive. There is particular interest in how serotonin modulates internal states given that serotonin dysregulation is a feature of many psychiatric diseases. In this thesis, I use the simplified serotonergic system of C. elegans to explore how serotonin governs the internal state of sickness. In addition to activating the immune system and remodeling physiology, pathogenic infection results in adaptive behavioral changes that promote …

A Neuronal Circuit Motif For Leaky Vector Integration, Abby Janke

Student Theses and Dissertations

To efficiently navigate their environments, animals ranging from insects to humans can keep track of their trajectory by continuously summing their direction and distance traveled over time. It is not clear how brains perform this fundamental computation––known as path integration––even though neural correlates and computer models abound. In arthropods, spatial-cognition related processes such as path integration are thought to be implemented in the central complex. Experimenters have shown that contiguously arrayed populations of neurons in the Drosophila fan-shaped body, a substructure of the central complex, display sinusoidally shaped bumps of calcium activity that signal vectors relevant for spatial navigation. The …

Mechanisms And Evolution Of Mitoribosomal Small Subunit Biogenesis, Nathan Harper

Student Theses and Dissertations

The ribosome is the macromolecular machine responsible for all protein synthesis in the cell and is one of the ancient molecular machines involved in the transfer of genetic information to functional molecules. The ribosome is made up of two conserved ribonucleoprotein complexes: the large subunit, responsible for peptide bond synthesis, and the small subunit, responsible for interrogating the match between mRNA codon and tRNA anti-codon. The assembly of the ribosome is a complex process which is tightly controlled to generate functional subunits which exhibit high translational accuracy and processivity. During ribosome biogenesis, ribosomal proteins and a multitude of additional assembly …

Neuromast Optogenetics Reveals Rules Of Spatial Encoding In The Zebrafish Lateral Line, Nicolas Velez-Angel

Student Theses and Dissertations

For animals to respond effectively to their environment, their sensory circuits must learn to distinguish between similar patterns of sensory information. A lingering question in neuroscience is how neuronal circuits achieve this performance. In this study, I use the posterior lateral line (pLL) of larval zebrafish to address this question. In the wild, the pLL must differentiate among a variety of hydrodynamic stimuli. However, understanding how fish distinguish between different water-flow stimuli has been challenging due to difficulties in stimulating individual neuromasts. To tackle this, I introduce a novel method in this thesis that combines single-neuromast optogenetics with whole-brain calcium …

Decoding Dynamic Gene Regulation In Hair Cell Development And Regeneration, Caleb C. Reagor

Student Theses and Dissertations

Identifying the causal interactions between genes and their proteins during the differentiation of specialized cells such as mechanosensory hair cells in vertebrates' inner ears and fishes' lateral lines requires an accurate description of the time-lagged relationships between transcription factors and their target genes. Here I describe Depicting Lagged Causality (DELAY), a convolutional neural network for the inference of gene-regulatory relationships across pseudotime-ordered single-cell trajectories. I first show that combining supervised deep learning with joint probability matrices of pseudotime-lagged trajectories allows the neural network to overcome important limitations of ordinary Granger causality-based methods, for example, the inability to infer cyclic …