Digital Commons Network^™

Molecular And Metabolic Regulation Of Gastrointestinal Cancer Metastasis, Norihiro Yamaguchi

Student Theses and Dissertations

Most of the cancer related mortality caused by metastatic disease rather than primary tumor growth. More than 80% of gastrointestinal cancers initially metastasize to the liver first. While the prognosis of early-stage cancers is improving, a significant proportion of patients have metastatic disease at the time of diagnosis leading to poor survival outcomes. I focused on colorectal cancer and pancreatic cancer, the second and third leading causes of cancer related death in the United States, due to the lack of molecularly targeted therapies available for these cancers. Moreover, understanding the pathophysiological basis of gastrointestinal cancer liver metastasis is of great …

Think Globally And Act Locally: Collaboration Across Borders To Address Climate Change, Allan T. Marks

Denver Journal of International Law & Policy

Climate change is a global challenge. International cooperation is essential yet insufficient. This tension is evident in negotiations of international climate agreements and at global climate conferences. In this context, it is worth asking why international law has so far failed sufficiently to address the global challenge of climate change and whether other types of cross-border collaboration can fill the void. Economic, political, and social factors inhibit accelerated and coordinated responses to climate challenges. The scope and direction of climate mitigation and adaptation are uneven, especially in the energy transition. The failure to reduce greenhouse gas emissions fast or far …

A Scent Of Direction: Exploring Adaptive Olfactory Navigation In Drosophila, Chad Morton

Student Theses and Dissertations

Animals rely on environmental cues, such as odors, to navigate through complex and often dynamic landscapes. While olfactory navigation has traditionally been modeled as a reflexive behavior driven by immediate sensory cues, whether flies can leverage more sophisticated strategies, integrating sensory input with spatial memory and internal representations of their surroundings, remains unclear. A key challenge in studying olfactory navigation lies in the invisible and unpredictable nature of odor plumes, which has made it challenging to accurately assess the ongoing sensory experiences of an animal. To address this challenge, we developed a novel virtual reality (VR) system that head-fixed Drosophila …

Prompt Engineering Guide: Scriptwriting Prompt Guide, Tonya Mcmillion

Generative AI

Prompt engineering guide for scriptwriting. Created as part of Collin College's Prompt Engineering Guide.

Occupational Exposures To Chemicals In Dentistry: A Scoping Review, Geneviève Picard, Tisha Prakash, France Labrèche, Sabrina Gravel

Revues de littérature, synthèses de connaissances

The dental workforce comprises a variety of professions, most of which are predominantly occupied by women. Dental workers can be exposed to numerous toxic chemicals such as mercury, methacrylate polymers, and silica. This scoping review aims to synthesize the scientific literature on quantified chemical exposures and to identify research gaps in occupational chemical hazards faced by dental professionals. This review followed the Joanna Briggs Institute approach and PRISMA-ScR guidelines, using three concepts to search PubMed, Embase, and Web of Science: workers, dental care, and chemicals. Studies from high-income countries, published in French or English between 2000 and 2024 and reporting …

Anime And Luxury Fashion: Studio Ghibli And Loewe's Unorthodox Brand Merchandizing, Theodore Gournelos, David Marutschke

Communication & Theatre Arts Faculty Publications

While they might seem counterintuitive to traditional concepts of “luxury,” collaborations between luxury and anime brands are a growing pattern reflecting the growth of both industries for key demographics. This paper argues that luxury brands use these collaborations to establish brand relevance and cultural connection while also positioning themselves advantageously against other brands in an increasingly social and online environment. Through a qualitative and quantitative content analysis of Instagram posts and user comments from Studio Ghibli and the Spanish luxury brand Loewe regarding their three product collaborations, we argue that there is a significant amount of room for differentiation in …

Optimal Tissue Clearing Of Gastric Cancerous Organoids Imaged Via High Resolution Light Sheet Microscopy, Lauren D. Lieu

2025 Fall Honors Capstones Projects - Archive

While the rate of surviving a myocardial infarction has increased in the past 60 years from 60% to 90%, the rate of Americans developing chronic heart disease such as heart failure, arrhythmias, and hypertensive heart disease has risen. This has led to the development of imaging technology such as Light Sheet Microscopy (LSM) and Light Field Microscopy (LFM) to study heart contractility and congenital heart disease via models such as cancerous organoids or Zebrafish. However, LSM and LFM results are highly dependent on the quality of the staining and cleared samples. This study looks to add to the growing field …

English Department Newsletter 2025, English Department, University Of Southern Maine

Department of English Newsletter

No abstract provided.

The Effect Of Zebra Mussels On Minnesota Fish Communities, Benjamin D. Strei

Journal of Earth and Life Science

Zebra mussels Dreissena polymorpha are an aquatic invasive species that has been spreading quickly throughout Minnesota water bodies since 1989. Zebra mussels are known to change certain morphological conditions in lakes such as turbidity, phytoplankton abundance, and aquatic invertebrate populations. However, studies showing impacts of the infestation of zebra mussels on the health of a fish community have been hard to prove due to a lack of repeated surveys and a suite of other confounding variables such as natural and seasonal variability, plant community, and lake morphometry. Therefore, the objective of this study is to determine whether zebra mussels have …

Quantity Over Quality? What Pupil Dilations Tell Us About Cognitive Effort At Learning., Durna Alakbarova

Psychology Dissertations - Archive

The current study examined whether pupil dilations at encoding reflect cognitive effort participants engage in a task. According to the cognitive effort hypothesis of pupil dilations, increases in cognitive effort cause activation of the locus coeruleus–norepinephrine (LC-NE) system, which is reflected in larger pupil dilations. While task-evoked pupillary responses (TEPRs) have been used as a marker of cognitive effort, it remains unclear whether changes in pupil size reflect encoding success. We proposed that the reason for conflicting findings on the topic is a lack of nuance in examining cognitive effort. Specifically, we suggested that cognitive effort consists of two separate …

Investigating Sex-Specific Role Of The Kynurenine Pathway In Opioid Withdrawal, Blake Brady

Psychology Theses - Archive

The opioid epidemic has led to a surge in opioid use disorder (OUD) and overdose deaths, making opioid withdrawal a critical area of study. Opioid withdrawal is characterized by both somatic and affective symptoms, including anxiety-like behaviors and physical withdrawal signs, yet the underlying neurobiological mechanisms remain insufficiently understood. The kynurenine pathway (KP), a primary metabolic route for tryptophan (TRP), is increasingly implicated in neuroinflammatory responses and neuropsychiatric disorders, yet its involvement in opioid use and withdrawal remains poorly studied, with even less known about potential sex-specific differences. Historically, the predominant use of male subjects in preclinical research has compounded …

Signal Analysis Of Calcium Dynamics In Pancreatic Cells, Abhidha Kunwar

2025 Fall Honors Capstones Projects - Archive

Calcium (Ca²⁺) signaling plays a critical role in insulin secretion from pancreatic βcells. Photo-biomodulation (PBM) of red or near-infrared wavelengths is applied to enhance cellular metabolism and Ca²⁺ activity in pancreatic cells. This study aims to rigorously analyze how PBM influences calcium dynamics in pancreatic cells by applying the Fast Fourier Transform (FFT), converting Ca²⁺ spiking patterns to the frequency domain to determine dominant oscillatory behaviors. Using a calcium-binding fluorophore, Ca²⁺ activity was acquired before and after PBM at 810 nm, processed with a machine learning algorithm, and further analyzed in MATLAB using FFT to assess changes in calcium signal …

Cdh-3/Cadherin, Yap-1/Yap And Egl-44/Tead Promote Syx-2/Syntaxin And Eff-1 Fusogen-Mediated Phagosome Closure, Alec Whited, Aladin Elkhalil, Ginger Clark, Piya Ghose

Biology Theses - Archive

Physical interactions between cells, such as cell-cell junctions, can profoundly impact cell fate. A vital cell fate for normal development and homeostasis is programmed cell death. Cells fated to die must be efficiently cleared away via phagocytosis, and defects are associated with a variety of diseased states. Whether cell-cell physical associations affect programmed cell elimination has not been well-explored. Here we describe, in vivo, a cell-cell adhesion-driven signaling pathway that ensures compartment-specific cell clearance during development. We previously described the specialized cell death program “Compartmentalized Cell Elimination” (CCE) in the C. elegans embryo. During CCE, the tail-spike cell (TSC), a …

The Impact Of Inter-Subunit Communication On F420h2:Nadp+ Oxidioreductase: A Kinetic Approach, Jamariya A. Howard

Chemistry & Biochemistry Dissertations - Archive

F₄₂₀H₂:NADP⁺ Oxidoreductase (Fno) catalyzes the reversible reduction of NADP⁺ to NADPH using reduced F₄₂₀ as the hydride donor. Both NADPH and the F₄₂₀ cofactor play significant roles in various metabolic pathways, including glycolysis and methanogenesis, particularly in methanogenic and sulfate-reducing archaea. These organisms play an essential role in global carbon cycling by converting carbon dioxide to methane through the methanogenic pathway, which is directly tied to energy production. This thesis investigates the hydride transfer mechanism of Fno from the extreme thermophile Archaeoglobus fulgidus, using fluorescence binding, steady-state and pre steady-state kinetics.

Chapter 1 outlines the structural and spectral characteristics …

The Alienated Self: A Solo Exhibtion, Kade Winterton

2025 Fall Honors Capstones Projects - Archive

Exhibiting works is an essential step for every artist; this capstone is a creative research project that explores feelings of alienation and otherness, as well as the multiple causes they stem from, resulting in a body of work ready for exhibition. First, research was conducted on exhibiting and curating works. Next, works by contemporary artists who also explored the same topic were examined. Completed works were curated, and an inventory of what was needed to create an exhibition-ready body of work was defined. After this was done, new works were uniquely created, each starting with an idea and a sketch. …

Impact Of Glufosinate On Soil Microbial Community Dynamics, Sarobi Das

Biology Dissertations - Archive

The increasing global regulations of glyphosate due to its possible carcinogenicity and environmental hazards have necessitated the search for alternative herbicides. Glufosinate-ammonium offers a sustainable attribute due to its low toxicity and limited reported herbicide resistance cases. Despite its increasing agricultural importance, very limited studies are done on its environmental impact, especially on the soil systems. This thesis examines the ecological behavior of glufosinate in soil, precisely focusing on its effect on the dynamics of soil microbiome and the potential use of Bradyrhizobium japonicum USDA110 for bioremediation by reversing the effect of microbial dysbiosis. A series of 30-day mesocosm studies …

How Individual Traits Predict Distribution Patterns And Community Convergence, Zachary K. Lange

Biology Dissertations - Archive

One of the fundamental questions in biology is whether natural conditions lead species and communities toward predictable outcomes. Answering this question requires understanding how traits of individual organisms are connected to species- and community-level patterns. In Chapter 2, I examined how thermal physiology and environmental temperatures interact to determine the distribution patterns of Anolis lizards on the Greater Antilles. I combined lab-measured thermal traits (critical thermal minimum: CT_min, critical thermal maximum: CT_max, thermal preference: T_pref) with occurrence and abundance data from 21 species of Anolis lizards collected from extensive mark-resight surveys of communities across …

Excitation And Polarization Of Isolated Neurons By High-Frequency Sine Waves For Temporal Interference Stimulation, Iurii Semenov, Vitalii Kim, Giedre Silkuniene, Andrei G. Pakhomov

Bioelectrics Publications

The capacity of temporal interference (TI) stimulation to target deep brain regions without affecting nearby surface electrodes remains uncertain. Using artifact-free optical recording, we compare excitation patterns and thresholds in hippocampal neurons stimulated by “pure” and amplitude-modulated sine waves, representing TI waveforms near electrodes and at the target, respectively. We show that pure 2- and 20-kHz sine waves induce repetitive firing at rates that increase up to 60–90 Hz with stronger electric fields. Beyond this limit, action potentials merge into sustained depolarization, resulting in an excitation block. Modulating the sine waves at 20 Hz aligns firing with amplitude “beats” and …

Comparative Life Cycle Assessment Of Conventional Open-Cut Pipeline Replacement With Trenchless Cured-In-Place Pipe Renewal Method For Wastewater Applications Using Midpoint Approach, Eesha Nilesh Karkhanis

Civil Engineering Theses - Archive

Underground infrastructure development has a significant impact on society, leading to continuous technological advancements. With the rising environmental concerns, novel technology is leaning towards adapting to sustainable practices for pipeline rehabilitation. Conducting a comparative study of environmental impacts produced by pipe renewal and replacement processes is a vital step towards sustainable development of underground infrastructure. Open-cut Pipeline Replacement (OCPR) is the conventional method used for pipeline rehabilitation, which involves the excavation of the ground surface to place a new pipe underground or replace an existing one. This process includes the trenching of ground, followed by surface reinstatement through backfill. The …

Assessing Stress, Anxiety, And Burnout In Undergraduate Veterinary Technology Students, Dean Ann Daughaday-Provine

Murray State Theses and Dissertations

Academic stress, anxiety, and burnout can negatively impact the mental health and well-being of students pursuing degrees in veterinary medicine. This quantitative study was designed to investigate the effects of academic stress, anxiety, and burnout on undergraduate students enrolled in Veterinary Technology programs. This study gained critical insight from current students transitioning through a rigorous curriculum of standards designed by the American Veterinary Medical Association (AVMA). The AVMA Committee on Veterinary Technician Education and Activities (CVTEA) has established standards, outlined in policies and procedures, to ensure the quality of assessments and enhancements in veterinary education within accredited Veterinary Technology programs.

Exploring A Collective Grief Experience In The U.S.: Qualitative Findings From Older Parents Whose Only Child Has Died, Yongqiang Zheng, Leslie Wuest, Jeongah Kim, Rebecca Rodriguez

Faculty Publications - College of Social Work

Despite its profound physical and mental health impacts, research on the loss of an only child in later life among older U.S. adults remains scarce. This phenomenological qualitative study explores the lived experiences and meanings older bereaved parents attribute to their loss. Data from 24 participants were collected through written narratives guided by structured questions, and online focus groups. Inductive thematic analysis revealed 6 themes: the enduring intensity of grief, significant secondary losses, feelings of isolation and alienation, the role of social support in coping, and spirituality and religion’s influence on their journey. By amplifying these parents’ voices, the study …

Denile On The Nile: Balancing Ethiopia's Equitable And Reasonable Utilization Of The Nile And Egypt's Desire To Maintain The Status Quo, Tyler Tipton

Case Western Reserve Journal of International Law

For nearly one hundred years, Egypt has maintained complete control and utilization of the Nile River under the 1929 Nile Agreement signed by Egypt and the United Kingdom. This agreement was amended in 1959, making Sudan a party but alienating the remaining Nile Basin States. Ethiopia has now posed the greatest challenge to the validity of these Agreements by constructing the Grand Ethiopian Renaissance Dam. This Note argues that the longstanding bilateral 1929 and 1959 Nile Agreements can no longer maintain their enforceability against the rest of the Nile Basin because they violate customary international water law and infringe on …

Abundance And Other Food Fixations, Margot J. Pollans

Elisabeth Haub School of Law Faculty Publications

Although most people in the United States no longer devote the majority of their time to food production, processing, and distribution, food remains a daily fixation. This Article explores three driving food fixations--abundance, thinness, and health--and situates each against an inverse fear--scarcity, fatness, and illness, respectively. Mapping these threats onto U.S. food policy, this Article examines, among other policy arenas, food waste policy, nutrition and health claim labeling law, and food additive regulations. Across food policy, these fixations feed what this Article calls the “politics of abundance.” This politics helps to insulate the food industry from deeper systemic reform aimed …

Vol. 28, No. 1: Full Issue, Water Law Review

Water Law Review

No abstract provided.

Regionality In Heart Failure Self-Care Behaviors Using The Medical Expenditure Panel Survey, Gretchen K. Wendt

Nursing Dissertations - Archive

Heart failure (HF) risks increase as patients age, with most of the HF patients having at least one chronic condition and 40% having two or more. Further confounding the HF morbidity and chronic medical conditions are psychiatric conditions like depression and anxiety. For most Americans with HF, managing the diagnosis and chronic conditions can be overwhelming. To formalize the definitions of HF disease management, the concepts of self-care from the situation-specific theory of HF self-care (SST-HFSC) were applied.

The medical complexity of HF self-care during the pandemic was shown to vary based on the US region where the individual resided. …

Field Trials Report 2024: Wa Farming Systems Project (Daw2204-003rtx), Department Of Primary Industries And Regional Development, Western Australia

Farm Systems and Economics research reports

Within the Western Australian Faming Systems Project, a program of 11 field trials were conducted in 2024 from Ogilvie in the north to Wittenoom Hills in the south.

The season was a challenging one with a late break to the season at all sites and varying conditions from decile 3 to decile 10 growing season rainfall across the sites.

Iactor: Integrating Flow Theory And Habit Principles To Combat Decision Fatigue In Audition Management, Colby L. Bell

Graduate Thesis and Dissertation post-2024

For many actors, the audition process can feel like a never-ending series of decisions—what to prepare, what to wear, what to bring, and how to keep track of it all. Each choice, though seemingly small, accumulates into a form of cognitive overload that can lead to burnout and disengagement. My fascination lies not only with how actors navigate this process but how we might reframe it. This thesis explores the question: How can I design a digital space that reduces decision fatigue and restores agency to actors preparing for auditions? Drawing from Mihaly Csikszentmihalyi’s Flow Theory, James Clear’s Atomic Habits …

Journeys Across Worlds, Carolina Guzman

Graduate Thesis and Dissertation post-2024

Journeys across Worlds is a collection of five short stories that transport readers into otherworldly landscapes. Each narrator embarks on a transformative journey, encountering adventure, wonder, and self-discovery. In “Through Borrowed Eyes,” a blind sorceress wields a powerful curse to see through the eyes of others, only to realize the cost of her magic may be too great. “A Gaze Across Dreams” follows a lonely Dreamweaver who, after an eternity of being unseen, is suddenly perceived by a lucid dreamer. The collection concludes with “Where the Skies Are Blue,” a tale of two sisters navigating a post-apocalyptic world, where the …

The Unindexed Marginalia Of Historical American Cookery Books Digital Public History Project: Domestic Technical Communication Labor Contributions, Alessandra Zinicola Lopez

Graduate Thesis and Dissertation post-2024

This dissertation includes a traditional written portion, and a non-traditional digital humanities public history online digital archive project created through Omeka which showcases examples of hand-written recipes found within commercial cookbooks, called marginalia. The understanding of modern technical communication is affected by the perceived history of the field and currently, that history is biased toward non-domestic pursuits. The project explores what collecting, digitizing, and archiving examples of historical hand-written marginalia found within commercially printed American receipt books indicate about the presence, participatory nature, value, and contributions of domestic technical communications and their user-authors in the 19th century. The examples collected …

Examination Of Users’ Privacy Issues In Live Streaming Information Disclosure, Yanlai Wu

Graduate Thesis and Dissertation post-2024

Live streaming has gained global popularity, raising significant privacy concerns due to its performance-driven, real-time, on-camera, and public nature. Increasing reports highlight privacy violations in live streaming, including streamers facing harassment from malicious viewers and bystanders being inadvertently exposed to audiences. Despite these challenges, research on privacy in live streaming remains limited. This dissertation addresses this gap by examining users' privacy concerns and strategies in information disclosure and exploring design solutions to enhance privacy management on live streaming platforms.

To achieve these objectives, I conducted three qualitative studies: two interview studies (Study 1: Chapter 4 and Study 2: Chapter 5) …