Digital Commons Network^™

Is Modulation Of Immune Checkpoints On Glioblastoma-Infiltrating Myeloid Cells A Viable Therapeutic Strategy?, Ruochen Du, Jianzhong Zhang, Rimas V Lukas, Shashwat Tripathi, Jared T Ahrendsen, Michael A Curran, Crismita Dmello, Peng Zhang, Roger Stupp, Ganesh Rao, Amy B Heimberger

Faculty, Staff and Students Publications

The field of immunology has traditionally focused on immune checkpoint modulation of adaptive immune cells. However, many malignancies such as glioblastoma are mostly devoid of T cells and rather are enriched with immunosuppressive myeloid cells of the innate immune system. While some immune checkpoint targets are shared between adaptive and innate immunity, myeloid-specific checkpoints could also serve as potential therapeutics. To better understand the impact of immune checkpoint blockade on myeloid cells, we systematically summarize the current literature focusing on the direct immunological effects of PD-L1/PD-1, CD24/Siglec-10, collagen/LAIR-1, CX3CL1/CX3CR1, and CXCL10/CXCR3. By synthesizing the molecular mechanisms and the translational implications, …

А Review Of Scorpiofauna Of China: Nomenclatural Notes And Updated Faunistic Catalogue (Arachnida: Scorpiones), Victoria Tang

Euscorpius

Two genera associated with the Chinese scorpiofauna are reviewed, Razianus Farzanpay, 1987 and Reddyanus Vachon, 1972. Holotype female of Razianus xinjianganus Lourenço et al., 2010 is presumed to be lost, as well as all type material of other Chinese scorpions described before 2020. Comments are given on the species composition of genus Reddyanus with a new synonym: Isometrus (Reddyanus) tibetanus Lourenço & Zhu, 2008 = Reddyanus assamensis (Oates, 1888) syn. n. Reddyanus kanak Lourenço, 2023 is tentatively considered as a nomen dubium. An updated catalogue of Chinese scorpiofauna is provided, including their type locality and type depository, protonym, synonym(s), …

Changes In Vertical Stratification Of Neotropical Nymphalid Butterflies At Forest Edges Are Not Directly Caused By Light And Temperature Conditions, Brian K. Oye, Ryan I. Hill

Pacific Faculty Work

Habitat fragmentation and land use changes threaten neotropical habitats and alter patterns of diversity at forest edges. Like other arthropod assemblages, neotropical fruit-feeding butterfly communities show strong vertical stratification within forests, with some recent work showing its potential role in speciation. At forest edges, species considered to be forest canopy specialists have been observed descending to the forest understory, with the similarity in light conditions between the canopy and understory strata at edges hypothesized to be responsible for this phenomenon. We conducted a study using standardized sampling to document and quantify this edge effect, characterize edge and forest strata, and …

Pope Francis On Forced Migration: A Pastoral Of Mercy And Its Relevance In The Indonesian Context, Alexander Hendra Dwi Asmara, Martinus Dam Febrianto

Asia Pacific Mission Studies

Dealing with refugees, was the late Pope Francis’ legacy, during his pontificate, both as the leader of the Catholic Church and a global figure. This article reviews Francis’ pastoral approach of mercy, especially in his concern and advocacy for migrants and refugees, as expressed through his gestures, statements, thoughts, proposals, and policies. Along with issues of global inequality and ecological damage, Francis believed that forced migration can only be addressed through joint efforts based on recognizing human dignity, solidarity, the need for participation, as well as connectivity and inclusivity that encompasses the entire human family. This article then highlights the …

Dissecting The Binding Affinity Of Anti-Sars-Cov-2 Compounds To Human Transmembrane Protease, Serine 2: A Computational Study, Yue-Hui Shi, Jian-Xin Shen, Yan Tao, Yuan-Ling Xia, Zhi-Bi Zhang, Yun-Xin Fu, Ke-Qin Zhang, Shu-Qun Liu

Faculty, Staff and Student Publications

The human transmembrane protease, serine 2 (TMPRSS2), essential for SARS-CoV-2 entry, is a key antiviral target. Here, we computationally profiled the TMPRSS2-binding affinities of 15 antiviral compounds. Molecular dynamics (MD) simulations for the docked complexes revealed that three compounds exited the substrate-binding cavity (SBC), suggesting noncompetitive inhibition. Of the remaining compounds, five charged ones exhibited reduced binding stability due to competing electrostatic interactions and increased solvent exposure, while seven neutral compounds showed stronger binding affinity driven by van der Waals (vdW) interactions compensating for unfavorable electrostatic effects (including electrostatic interactions and desolvation penalties). Positive and negative hotspot residues were identified …

Tyrone Lee Dunn, Sr.

African American Funeral Programs

Tyrone Lee Dunn, Sr.pdf - Funeral program for Tyrone Lee Dunn

The Eastern Oyster Behavioral Response To Low Salinity And Hypoxia In Controlled And Natural Settings, Siyah Yongue

LSU Master's Theses

Oyster aquaculture is expanding in the northern Gulf of Mexico, but climate change may challenge the sustainability of this industry. Projected increases in the frequency and intensity of low salinity and low dissolved oxygen (DO) periods could impact the behavior, metabolism, growth, and survival of oysters. Characterizing how oyster behavior links to environmental stressors could help better identify thresholds in their tolerance and inform predictive tools for aquaculture professionals. In this research, the effect of separate and concomitant exposures to low salinity and DO on the behavioral response of oysters was examined in the lab. The impact of other environmental …

Rethinking Immigration Enforcement, Peter L. Markowitz

Florida Law Review

As the nation turns the page away from the dark chapter of President Trump’s relentless assault on immigrants, it is time to take stock of the nation’s unprecedented immigration enforcement regime. During its relatively short existence, the Immigration and Customs Enforcement agency (ICE) has deported more than twice as many people as were deported in the entire previous history of the United States. The human and fiscal costs of ICE’s mass deportation agenda are astronomical, and there is almost universal agreement across the political spectrum that the United States’ immigration enforcement apparatus is badly broken. That, however, is where the …

Reallocating Redevelopment Risk, Michael C. Pollack

Florida Law Review

Scores of cities across the country face devastating financial crises, and the COVID-19 pandemic has brought even more to the brink. But economically distressed municipalities have few places to turn for help. Saddled by rising unemployment, weak tax bases, and state law limitations on deficit spending and debt assumption, they generally cannot spend their way out. And as conditions deteriorate, mobile capital and labor move to greener pastures, further hollowing out the cities they leave behind. With state and federal lifelines tenuous at best, offers by large developers to redevelop an area of the city can thus appear to be …

Modernizing Capacity Doctrine, Lisa V. Martin

Florida Law Review

Federal capacity doctrine—or the rules establishing whether and how children’s civil litigation proceeds—has largely remained the same for more than a century. It continues to presume that all children are incapable of directing their own cases, and that adults must litigate on children’s behalf. But since that time, our understanding of children, and of adolescents in particular, has significantly evolved. This Article contends that it is well beyond time to modernize the capacity doctrine to better account for the capabilities of adolescents and support their transition to adulthood.

Performance And Emissions Characteristics Of Multi-Cylinder Direct Injection Diesel Engine Fuelled With Diesel/Biodiesel And Toluene Additives, Hagar Alm-Eldin Bastawissi, Medhat Elkelawy Prof. Dr. Eng., Mohammed Osama Elsamadony Dr. Eng., Moustafa Ghazaly Eng.

Journal of Engineering Research

This study explores the impact of using a diesel, biodiesel, and toluene additive fuel blend in a multi-cylinder direct injection diesel engine, focusing on both performance and emissions characteristics. Biodiesel, made from renewable sources like vegetable oils, is often added to diesel to reduce reliance on fossil fuels and improve combustion due to its higher oxygen content. In this work, a 45% biodiesel blend (B45) led to significant reductions in particulate matter (PM) emissions by up to 40% compared to conventional diesel. Additionally, carbon monoxide (CO) and hydrocarbon (HC) emissions decreased by up to 30% and 25%, respectively, due to …

Comparison Of Virtual Vs. Traditional Cycling Exercise On Perceived Duration And Exercise Enjoyment: A Pilot Study, Kyle W. Reason, Lauren G. Killen, T. Scott Lyons, Jean A. Helm Allen, Matt Green

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 147-157, 2025. Participating in regular physical activity has been shown to increases one’s quality of life. Individuals may choose not to participate in regular physical activity because of a perceived lack of time and enjoyment. With the potential of these barriers to decrease exercise adherence, the purpose of this study was to compare perceived exercise duration and enjoyment between a virtually interactive stationary bike and a clamped workload on a standard non-interactive stationary bike. Thirteen active participants completed a VO₂ peak test and four counterbalanced trials (two 20-min, two 40-min) with one trial …

Full Issue, Continental Birdlife

Continental Birdlife

No abstract provided.

Field Studies Of Bird Migration - A Brief Overview And Someunanswered Questions, Kenneth P. Able

Continental Birdlife

No abstract provided.

The Eastern Bluebird In The Highlands Of Southeastern New York State, Robert Speiser, John Benzinger

Continental Birdlife

No abstract provided.

Tool Use By A Mountain Chickadee, Philip Gaddis

Continental Birdlife

No abstract provided.

Comment On Tool-Using In Birds, Jeffery Boswall

Continental Birdlife

No abstract provided.

Book Reviews, Continental Birdlife

Continental Birdlife

No abstract provided.

Fashionable Sustainable Leather, Özgenur Battal, Mervenur Acar, Muhammet Uzun

Journal of Art, Design and Music

In recent years, there has been a growing interest in the leather industry towards sustainable and innovative alternatives to traditional leather production methods. Alongside this trend, efforts have been made to reduce environmental damage by focusing on natural tanning methods in the production of natural leather, thus adopting more sustainable production techniques. Alternative materials such as apple leather, pineapple leather, banana leather, cactus leather, bacterial cellulose leather and cork leather have emerged as viable options in response to this shift. Additionally, there has been notable development in exotic leather alternatives, with materials like crocodile, puffer fish, and ostrich leather taking …

Morphological And Scanning Electron Microscopy Characterization Of A Spirurid In A Wild Sunda Pangolin (Manis Javanica), Punnarat Vibulchan, Chong Shin Min, Chiharu Okumura, Piyanan Taweethavonsawat

The Thai Journal of Veterinary Medicine

This study identifies and characterizes a spirurid in a wild Sunda pangolin (Manis javanica) using scanning electron microscopy (SEM). Native to Southeast Asia, the Sunda pangolin faces critical threats from poaching, illegal trafficking for its scales and meat, habitat loss, urban conflicts, and disease. Despite this, little is known about the biology of wild Sunda pangolins. In this research, spirurid parasites were recovered from a pangolin fatally injured in a vehicular collision. The parasites were preserved and analyzed with SEM, revealing key morphological features such as papillae, lip-like structures, and an anal opening in females. This study enhances …

The Use Of Ethyl Lauroyl Arginate Encapsulated In Organic Nanoparticles Within Boar Semen Extenders To Control Bacterial Growth And Preserve Sperm Quality During Short-Term Storage Without Antibiotics, Congbang Ngo, Naiyaphat Nittayasut, Teerapong Yata, Junpen Suwimonteerabutr, Nuvee Prapasarakul, Jane M. Morrell, Padet Tummaruk

The Thai Journal of Veterinary Medicine

The aim of the present study was to investigate the effect of adding ethyl lauroyl arginate (ELA), encapsulated in organic nanoparticles, to a semen extender without antibiotics on sperm quality and bacterial load during short-term storage. Three ejaculates from Duroc boars were divided into four equal portions and diluted with Beltsville Thawing Solution to produce semen doses containing 3 billion spermatozoa in 80 ml. The extended semen did not include antibiotics but instead incorporated different concentrations of ELA nanoparticles into the extenders: 0 ppm, 5 ppm, 10 ppm, and 15 ppm. The semen doses were stored for 4 days, with …

Correlation Of Classical Swine Fever (Csf) Antibody Protective Level Detected By Enzyme-Linked Immunosorbent Assay And Serum Neutralization Test, Chairani Ridha Maghfira, Nguyen Thanh Che, Apisit Kittawornrat, Roongroje Thanawongnuwech, Yaowalak Panyasing

The Thai Journal of Veterinary Medicine

Protective antibody against classical swine fever virus (CSFV) is an important parameter used for disease monitoring in CSFV-endemic areas. Enzyme-linked immunosorbent assay (ELISA) is a simple and practical serological assay for CSFV antibody detection. However, the use of CSFV ELISAs in CSFV antibody-positive herds, i.e., CSFVvaccinated or -previously infected herds, was limited by an application of the test results. This study aimed to evaluate the correlation and estimation of protective antibody levels detected by ELISA and serum neutralization assay. A total of 522 negative and positive serums were tested by SN and ELISA in parallel. Comparisons of sample-to-positive (S/P) values …

Thought And Exemplary Islamic Nationalism Of The Early Days Of Independence Indonesia: Learning From Ki Bagus Hadikusumo, Dikdik Baehaqi Arif, Sapriya Sapriya, Dasim Budimansyah, Syaifullah Syaifullah

Jurnal Civics: Media Kajian Kewarganegaraan

Indonesian nationalism is characterised by a blend of religious and national identities that coexist and reinforce each other. This paper presents a profile of the background of Ki Bagus Hadikusumo's thoughts, life, and nationalism during the early days of Indonesian independence. Ki Bagus Hadikusumo is one of Indonesia's national heroes who can be classified as an Islamic nationalist during the formulation of the Indonesian state. This figure, active in the Muhammadiyah Islamic movement organisation, has significantly contributed to the formulation and establishment of Pancasila as the basis of the state. The life background thought, and Muhammadiyah as the organisation of …

Preserving State Police Powers: Why The Supreme Court’S National Pork Producers Council V. Ross Decision Is Correct, Anna Kate Cagle

Journal of Health Care Law and Policy

No abstract provided.

High Hopes: Legal And Ethical Issues With Post-Trial Access To Psychedelic Drugs, Callie Terris, Emma Tumilty

Journal of Health Care Law and Policy

No abstract provided.

A Stewardship Of Land And Creatures, Jeremy Hummel

Faculty Work Comprehensive List

"A fuller, richer vision of agriculture is no less than one that supplies varied types of services for humans while also ministering to the need for creation to praise its Creator through its own being."

Posting about the calling of agriculture from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

A Stewardship of Land and Creatures

Securing A Virtual Reality Classroom Using Unity, Okemute Samuel Idonor

Theses and Dissertations

This study examines how security features might be incorporated into a Unity created virtual reality (VR) classroom, with a particular emphasis on important concerns including user privacy, data security, and illegal access. The increasing usage of virtual reality (VR) technology in educational settings has made it crucial to ensure the security of these immersive systems, especially when it comes to safeguarding sensitive user data. Designing and implementing a secure VR classroom prototype that could successfully protect against common security concerns, such as unauthorized access and data breaches, was the main goal of this project. Multi-Factor Authentication (MFA), Role-Based Access Control …

Heavy Metals Pollution In Roadside Ecosystems, Lilian Matafu

Tanzania Journal of Engineering and Technology (TJET)

Heavy metals refer to metallic elements that are characterized by having a relatively high density and they are toxic or poisonous even at low concentration. They are environmental pollutant owing to toxicity and longevity in atmosphere and ability to accumulate in living things via bioaccumulation. They tend to enter in different system such as food chain. Analyses of water, soil sediment and the surrounding growing plants (Cynodon dactylon and Cyperus species) for selected heavy metals (Cd, Pb, Zn and Cu) were conducted on a roadside pond located at Boko MSB, Dar es Salaam. Pond water, soil sediments and plant samples …

Assessment Of Adaptation And Diffusion Of Biogas Technology A Case Study Of Dar Es Salaam City, Tanzania, Doreen L. Tarimo

Tanzania Journal of Engineering and Technology (TJET)

This study investigated the adaptation and diffusion of biogas technology in Dar es Salaam, driven by the increasing need for sustainable energy solutions. The study’s is rooted in addressing urban energy challenges and providing an eco-friendly waste management alternative. Various factors, including socioeconomic variables, technical efficiencies, and community-level acceptability, were examined to assess the technology’s adaptability and diffusion. Data collection methods and techniques included lab analysis using American public health association (APHA) standard methods, interviews, questionnaire administration the data analysis was undertaken using statistical package for the social sciences (SPSS) with a sample size comprising 100 household heads from Mburahati, …

The State Of Global And African Ecology, Peter Knox

Landas

This article recounts the growth of concern for the environment in the latter half of the 20th Century, and its entry into Catholic magisterial theology. It expands on the ecological theory of planetary boundaries, and identifies how the theory surfaces in Pope Francis’ 2015 encyclical Laudato Si’. Based upon solid contemporary science, the encyclical is well founded to outline an appropriate and compassionate moral theology of care for creation. The article cites multiple instances where African people are at the nexus of environmental and social crises, focusing on how contemporary ecological factors affect women in particular. Environmental crises should not …