Digital Commons Network^™

Superstable Lipid Vacuoles Endow Cartilage With Its Shape And Biomechanics, Raul Ramos, Kim T Pham, Richard C Prince, Leith B Leiser-Miller, Maneeshi S Prasad, Xiaojie Wang, Rachel C Nordberg, Benjamin J Bielajew, Jerry C Hu, Kosuke Yamaga, Ji Won Oh, Tao Peng, Rupsa Datta, Aksana Astrowskaja, Axel A Almet, John T Burns, Yuchen Liu, Christian Fernando Guerrero-Juarez, Bryant Q Tran, Yi-Lin Chu, Anh M Nguyen, Tsai-Ching Hsi, Norman T-L Lim, Sandra Schoeniger, Ruiqi Liu, Yun-Ling Pai, Chella K Vadivel, Sandy Ingleby, Andrew E Mckechnie, Frank Van Breukelen, Kyle L Hoehn, John J Rasweiler, Michinori Kohara, William J Loughry, Scott H Weldy, Raymond Cosper, Chao-Chun Yang, Sung-Jan Lin, Kimberly L Cooper, Sharlene E Santana, Jeffrey E Bradley, Michael A Kiebish, Michelle Digman, David E James, Amy E Merrill, Qing Nie, Thomas F Schilling, Aliaksandr A Astrowski, Eric O Potma, Martín I García-Castro, Kyriacos A Athanasiou, Richard R Behringer, Maksim V Plikus

Faculty, Staff and Student Publications

Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct and produced lipids exclusively through de novo lipogenesis. Consequently, lipochondrocytes grew uniform lipid droplets that resisted systemic lipid surges and did not enlarge upon obesity. Lipochondrocytes also lacked lipid mobilization factors, which enabled exceptional vacuole stability and protected cartilage from shrinking upon starvation. Lipid droplets modulated lipocartilage biomechanics by decreasing the tissue's stiffness, strength, and resilience. Lipochondrocytes were found in multiple mammals, including humans, …

Alzheimer’S Disease: Relationship Of Cognition And Behavior To Neurochemistry, Peter J. Whitehouse

Faculty Scholarship

Alzheimer’s disease is characterized by loss of cells and synapses in specific neural systems. The development of more effective therapies will depend on understanding the relationships between this pathology and the cognitive and behavioral impairments. In this review, focusing primarily on work in our laboratory, we will examine both classic and neuropeptide neurotransmitter systems and will discuss conceptual and methodological problems in relating clinical and biological measures.

Joe Rogan Experience #2255 - Mark Zuckerberg, Joe Rogan, Mark Zuckerberg

Zuckerberg Transcripts

No abstract provided.

The Role Of Exosomes In Medical Dermatology: Literature Review And Update, Victoria Dukharan, Milaan Shah, Luke Broughton, Carol Stegura, Luna Samman, Nina Schur, Jacqueline M. Luna, Daniela Gutierrez Mendoza, José Ramón García Lira, Adriana María Valencia-Herrera, Jona Louise D. Macaraeg-Jimenez, Victoria G. Belo, Regina Gabrielle Gatan, Suparuj Lueangarun, Ana Cecilia Amador Ruiz, Karolina Ziemlewski, Zuramis Estrada Blanco, Todd Schlesinger

GME Publications

Background

Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that are primarily derived from stem cells. The contents of exosomes can be incorporated into the tissue in which they are introduced, which presents a unique therapeutic option.

Aims

Exosomes have been investigated as a treatment for a number of medical ailments, but the literature supporting these indications is inconclusive. In addition, much of the study on exosomes and their uses has been recently completed. Thus, this review summarizes the efficacy and implications of exosomes in the treatment of different dermatologic conditions.

Methods

A literature review surrounding the use of …

Languaging The Infrathin Of The Everyday Un/Clear, Claire Walsh, Edward Reardon

School of Law, Humanities and Social Sciences

This paper plays within the moments felt as subject(ivity) formed within actual events, moments Whitehead describes as actual occasions. Moments pulled away from creative becoming, the Deleuze/Guattari conceptualisation of affect, their immanently relational nonbeing, to attune, or retune, into conformations acceptable to what Moten and Harney speak into as logistical capitalism and its assemblage of the ‘proper way to do things’.It is a thinking within the comprehensibility of logistical capitalism aiming “...to straighten us out, untangle [unravel] us...in the constant measure and regulation of flesh and earth,” conversing with Manning’s concept of the clear – the violent colonial destruction of …

Differential Encoding Of Mammalian Proprioception By Voltage-Gated Sodium Channels, Cyrrus M. Espino, Chetan Nagaraja, Serena Ortiz, Jacquelyn R. Dayton, Akash R. Murali, Yanki Ma, Emari L. Mann, Snigdha Garlapalli, Ross P. Wohlgemuth, Sarah E. Brashear, Lucas R. Smith, Katherine A. Wilkinson, Theanne N. Griffith

Faculty Research, Scholarly, and Creative Activity

Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily life, the mechanisms governing proprioceptor activity are poorly understood. Here, we identified nonredundant roles for two voltage-gated sodium channels (NaVs), NaV1.1 and NaV1.6, in mammalian proprioception. Deletion of NaV1.6 in somatosensory neurons (NaV1.6cKO mice) causes severe motor deficits accompanied by loss of proprioceptive transmission, which contrasts with our previous findings using similar mouse models to target NaV1.1 (NaV1.1cKO). In NaV1.6cKO animals, we …

Molecular Dynamics At Immune Synapse Lipid Rafts Influence The Cytolytic Behavior Of Car T Cells, Ahmed Z Gad, Jessica S Morris, Lea Godret-Miertschin, Melisa J Montalvo, Sybrina S Kerr, Harrison Berger, Jessica C H Lee, Amr M Saadeldin, Mohammad H Abu-Arja, Shuo Xu, Spyridoula Vasileiou, Rebecca M Brock, Kristen Fousek, Mohamed F Sheha, Madhuwanti Srinivasan, Yongshuai Li, Arash Saeedi, Kandice R Levental, Ann M Leen, Maksim Mamonkin, Alexandre Carisey, Navin Varadarajan, Meenakshi Hegde, Sujith K Joseph, Ilya Levental, Malini Mukherjee, Nabil Ahmed

Faculty, Staff and Students Publications

Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse (CARIS) could explain differences in their tumor rejection kinetics. We observed that CD28.ζ-CART engaged in brief highly lethal CARIS and mastered serial killing, whereas 4-1BB.ζ-CART formed lengthy CARIS and relied on robust expansion and cooperative killing. We analyzed CARIS membrane lipid rafts (mLRs) and found that, upon tumor engagement, CD28.ζ-CAR molecules rapidly but transiently translocated into mLRs, mobilizing the microtubular organizing center and lytic granules …

Book Review: The Evolving Tax: A Review Essay, Steven M. Sheffrin

Florida Tax Review

Review of: Tax and Government in the Twenty-First Century, Miranda Stewart, Cambridge University Press, 2022, pp. 407.

The Shifting Economic Allegiance Of Capital Gains, Amanda Parsons

Florida Tax Review

Technological advances and the digitalization of the global economy have created an economic environment beyond the imagination of the original designers of the international tax system. Much scholarly attention has been paid to the question of how these economic transformations should affect which country is able to tax a multinational company’s income. But which country should be able to tax capital gains income from the sale of that company’s shares is an important and overlooked question.

This Article answers this question. It concludes that taxing authority over capital gains income must be reallocated to the countries in which companies conduct …

The Dubious Constitutional Origins Of Treaty Overrides: A Response To Rosenbloom And Shaheen, Reuven S. Avi-Yonah

Florida Tax Review

In 1888, the Supreme Court decided a case called Whitney v. Robertson, which is generally considered to be the source of the proposition that, under the Constitution, later-in-time statutes can override earlier treaties (the Rule). The Rule is highly controversial because it violates articles 26 and 27 of the Vienna Convention on the Law of Treaties (VCLT), which the United States has accepted as binding on it as customary international law (CIL). Despite that, the United States has since Whitney routinely engaged in treaty overrides, and the Court has repeatedly endorsed the Rule even while narrowing its application to …

Tcas Board Meeting, Laurel Wilson

North Texas Archeological Society Records

Undated board meeting minutes for TCAS.

Tcas Meeting Minutes November 2008, Laurel Nuncio

North Texas Archeological Society Records

TCAS meeting minutes for November 5, 2008.

Tcas Meeting Minutes October 2008, Katrina Nuncio

North Texas Archeological Society Records

TCAS meeting minutes for October 1, 2008.

Advancing The Effectiveness Of Pharmaceutical Quality Systems Via Qrm And Km: A Compilation Of Open Access Literature By The Prst, Martin J. Lipa, Anne Greene (Editor)

Journal of Applied Pharmaceutical Regulatory Science

This paper provides readers a convenient compilation of open access literature including journal articles and PhD theses published by the Pharmaceutical Regulatory Science Team (PRST) over the last several years on the topics of Quality Risk Management (QRM) and Knowledge Management (KM). These topics, established as the dual enablers of a modern pharmaceutical quality system (PQS) as defined in ICH Q10, have been an area of focus of several PhD research studies over the past several years. A common theme across these research studies, as presented across this compilation of papers, is to advance PQS effectiveness and the goals of …

The Degree Of The Possession Of Designing, Managing And Practicing Electronic Courses Competencies By Faculty Members At The Palestinian Universities, Ashraf Al Hennawi

Journal of the Arab American University مجلة الجامعة العربية الامريكية للبحوث

The current study aimed to reveal the degree of the possession of designing, managing and practicing electronic courses competencies by faculty members at the Palestinian universities. The researcher prepared a questionnaire to measure the degree of the possession of those competencies, and achieve the objectives of the study. The researcher followed the descriptive approach to describe the phenomenon under study. The study was applied to a sample of 388 randomly selected faculty members in three Palestinian universities (Al-Aqsa - Khadoori - Islamic). The results of the degree of the possession of designing and managing electronic courses competencies by faculty members …

Met 205-102: Advanced Computer Aided Design, Maximiliano Rodriguez

School of Applied Engineering and Technology Syllabi

No abstract provided.

Species Differences In The Biotransformation Of Aflatoxin B1: Primary Determinants Of Relative Carcinogenic Potency In Different Animal Species, David L. Eaton, David E. Williams, Roger A. Coulombe

Animal, Dairy, and Veterinary Science Faculty Publications

It has been known since the early days of the discovery of aflatoxin B1 (AFB1) that there were large species differences in susceptibility to AFB1. It was also evident early on that AFB1 itself was not toxic but required bioactivation to a reactive form. Over the past 60 years there have been thousands of studies to delineate the role of ~10 specific biotransformation pathways of AFB1, both phase I (oxidation, reduction) and phase II (hydrolysis, conjugation, secondary oxidations, and reductions of phase I metabolites). This review provides a historical context and substantive analysis of each of these pathways as contributors …

Brain Delivery Of Erythropoietin Results In A Significant Reduction Of Brain Aβ And Spatial Memory Deficits In The App Knock-In Mouse Model, Rudy Tieu Chang, Devaraj V. Chandrashekar, Grace-Ann Chuli Roules, Emi Iwasaki, Nataraj Jagadeesan, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Background

Although novel treatments for Alzheimer’s disease (AD) have begun to show modest therapeutic effects, agents that target hallmark AD pathology and offer neuroprotection are desired. Erythropoietin (EPO) is a glycoprotein hormone with neuroprotective effects but is faced with challenges including limited brain uptake and increased hematopoietic side effects with long-term dosing. Therefore, EPO has been modified and bound to a chimeric transferrin receptor monoclonal antibody (cTfRMAb); the latter shuttles EPO past the blood-brain barrier (BBB) into brain parenchyma and reduces its plasma exposure and potential for side effects. Our study sought to characterize the safety and pharmacokinetics (PK) of …

Effects Of Pericarp Removal And Different Germination Conditions On Seed Germination And Saline-Alkali Tolerance Of Amorpha Fruticosa, Zhan-Wu Gao, Yong-Guang Mu, Feng Chen, Li-Jie He, Xin-Ning Li, Jia-Tong Li, Ke-Jia Ding, Yan-Hui Cu, Chun-Sheng Mu, Adnan Rasheed

Turkish Journal of Botany

In this paper, neutral salt NaCl and basic salt Na2CO3 were used to simulate salt stress and alkali stress respectively, and the effects of salt stress and alkali stress on seed germination and growth changes in natural saline-alkali soil were studied, in order to provide theoretical basis for making full use of plant resources and improving production efficiency. The fruit peel of Amorpha fruticosa contains a lot of lipids, which has a significant effect on seed germination. Under salt stress, removal of pericarp significantly increased germination rate, germination potential and germination index (P< 0.05), and significantly shortened germination time of seeds (p< 0.05), which accelerated the establishment of seedlings, reduced the stress time during germination, and advanced the transition from heterotrophic to autotrophic, accumulating more anions and organic solutes to adapt to salt stress. Therefore, when planting in neutral salt soil, it can be used to remove the peel for sowing to improve the planting effect. However, under alkali stress, the growth is inhibited by the absorption of a large amount of Na+ and high pH value, so it is not suitable for removing the peel for sowing. Different germination conditions had significant effects on seed germination. The length and biomass of radicle and germ in sand culture were significantly higher than those in paper culture (P< 0.05). Under the condition of sand culture, the concentration of the treatment solution can be well maintained, which is conducive to fixing the seedlings and reducing the interference of other mineral elements. Therefore, sand culture method is recommended for seed germination experiments under stress, especially for plants with developed roots.

Impact Of Anoxygenic Phototrophic Bacteria On The Growth Of Arabidopsis Thaliana Under Salt Stress, Behi̇ye Nur Aksoy, Hamza Ettadili, Caner Vural

Turkish Journal of Botany

The effect of a microbial mixture containing anoxygenic phototrophic bacteria (APB) on the growth of Arabidopsis thaliana ecotype Col-0 under salt stress was investigated. To induce salt stress, 150 mM NaCl was applied to A. thaliana. Four treatments were employed to assess the impact of APB: (1) control plants, (2) plants inoculated with a mixture of enriched photosynthetic bacteria, (3) plants inoculated with a mixture of enriched photosynthetic bacteria and irrigated with 150 mM NaCl solution, and (4) plants irrigated with 150 mM NaCl solution. The analysis demonstrated that the inoculated plants exhibited increased leaf formation and leafsize. Furthermore, an …

Microrna 133a Regulates Squalene Epoxidase Expression In Colorectal Cancer Cells To Control Cell Proliferation And Cholesterol Production, Ji Su Mo, Santosh Lamichhane, Grinsun Sharma, Soo Cheon Chae

School of Medicine Faculty Publications

Background/Objectives: Colorectal cancer (CRC) is one of the most common cancers worldwide, with high incidence and mortality rates. MicroRNAs are endogenous and non-coding RNAs that play a pivotal role in the development and progression of various cancers by targeting specific genes. Previously, we identified MIR133A to be significantly decreased in human CRC tissues. This study aims to identify the relationship with SQLE, one of the candidate target genes of MIR133A, and study their interaction in CRC cells. Methods: Through the luciferase reporter assay, quantitative RT-PCR (qRT-PCR), and Western blot analysis. Results: We identified SQLE as a direct target gene of …

Acetylcholine Treatments Enhance Growth, Photosynthesis Efficiency And Stress Resilience In Maize Seedlings Exposed To Arsenic, Büşra Arikan-Abdulveli

Turkish Journal of Botany

Arsenic (As) is a widespread and highly toxic metalloid that adversely affects plant health, leading to reduced yields, impaired photosynthesis, and compromised root structures. Although acetylcholine (ACh), a neurotransmitter implicated in plant growth and stress responses, has shown potential in mitigating heavy metal stress, its effects on As stress in maize (Zea mays L.) remain largely unexplored. This study investigated the impact of ACh treatments on maize seedlings exposed to As stress (100 µM), focusing on physiological responses, growth rates, photosynthesis, and the antioxidant system. Our findings revealed that ACh treatments conferred differential protective effects against As stress. The lowest …

Ghost Fishing Due To Derelict Crab Traps In Louisiana’S Barataria Basin, Emma C. Villemarette

LSU Master's Theses

Ghost fishing, the unintentional entrapment of sea life by derelict fishing gear, is an ecologic and socioeconomic concern in Louisiana's crabbing industry (blue crab, Callinectes sapidus). These ghost fishing traps cause unknown and unaccounted for mortality in blue crab and bycatch species. I aimed to track changes to derelict crab trap catch and trap deterioration over seasons and between habitats. I set and monitored 33 simulated derelict crab traps over 367 soak days in three varying habitats along Barataria Bay, Louisiana. Traps were checked once every two weeks and an additional daily check for five days per season. Blue …

Could Manure Help Cool-Climate Farmers Get Closer To Year-Round Farming?, Nicholas Gosling

UNH Today Archive

No abstract provided.

Contacts And Continuities: 500 Years Of Asian-Iberian Encounters, Conference Program And Abstracts

Perspectives in the Arts and Humanities Asia

No abstract provided.

Mlk Day Of Service, Events To Honor Civil Rights Leader's Legacy, Marvis Herring

University of Mississippi News

OXFORD, Miss. – The University of Mississippi community will honor the life and legacy of the Rev. Martin Luther King Jr. through its annual MLK Day of Service and a memorial dinner and celebration.

"Safe Third Country": Democratic Responsibility And The Ends Of International Human Rights, Paul Linden-Retek

Contributions to Books

Published as Chapter 3 in Lawless Zones, Rightless Subjects: Migration, Asylum, and Shifting Borders, Seyla Benhabib & Ayelet Shachar, eds.

Perinuclear Organelle Trauma At The Nexus Of Cardiomyopathy Pathogenesis Arising From Loss Of Function Lmna Mutation, Jason C. Choi

Center for Translational Medicine Faculty Papers

Over the past 25 years, nuclear envelope (NE) perturbations have been reported in various experimental models with mutations in the LMNA gene. Although the hypothesis that NE perturbations from LMNA mutations are a fundamental feature of striated muscle damage has garnered wide acceptance, the molecular sequalae provoked by the NE damage and how they underlie disease pathogenesis such as cardiomyopathy (LMNA cardiomyopathy) remain poorly understood. We recently shed light on one such consequence, by employing a cardiomyocyte-specific Lmna deletion in vivo in the adult heart. We observed extensive NE perturbations prior to cardiac function deterioration with collateral damage in the …

Volume 12, Numbers 1-2, 2022, Full Issue

Perspectives in the Arts and Humanities Asia

No abstract provided.

On Translating Adelina Gurrea’S “La Doncella Que Vivió Tres Vidas”, Jonathan Chua, Ma. Luisa Young

Perspectives in the Arts and Humanities Asia

This is an account of the translation process that went into the English translation of the story “La doncella que vivió tres vidas” (1943) by Adelina Gurrea, a writer of Spanish and Filipino descent. Gurrea’s Cuentos de Juana, from which the story is taken, occupies a liminal space in the literary history of the Philippines, as it was published in Spain for a Spanish-reading audience, yet it is borne of her childhood in Negros, in the Philippines. The story illustrates Maria Tymoczko’s observation that postcolonial writing and interlingual translation are similar. Both are acts of representing the “foreign,” a linguistic …