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Articles 17971 - 18000 of 23017
Full-Text Articles in Entire DC Network
Myristoylated Eepd1 Enhances Lipolysis And Thermogenesis Through Pka Activation To Combat Obesity, Suzhen Chen, Yanping Wang, Qian Zhou, Qiqi Qian, Quanxin Jiang, Chuchu Liu, Yan Liu, Peihui Zhou, Jie Xiong, Yao Zhang, Ning Wang, Yang Emma Li, Limin Yin, Hongyuan Yang, Junli Liu
Myristoylated Eepd1 Enhances Lipolysis And Thermogenesis Through Pka Activation To Combat Obesity, Suzhen Chen, Yanping Wang, Qian Zhou, Qiqi Qian, Quanxin Jiang, Chuchu Liu, Yan Liu, Peihui Zhou, Jie Xiong, Yao Zhang, Ning Wang, Yang Emma Li, Limin Yin, Hongyuan Yang, Junli Liu
Faculty, Staff and Student Publications
Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset. Eepd1 is primarily expressed in adipose tissue, where its downregulation or deletion accelerates obesity development. We show that Eepd1 ablation hinders PKA activation, thereby inhibiting lipolysis and thermogenesis in adipose tissue. Notably, cold exposure enhances Eepd1's myristoylation, facilitating its anchorage to adipocyte membranes and subsequent activation of PKA, while a mutation …
A Framework For A Sustainable Archaeology Field School In South Florida, Alanna L. Lecher, Katharine G. Napora, Sara Ayers-Rigsby, Malachi Fenn, Melissa Lehman, Peter De Witt, John Sullivan
A Framework For A Sustainable Archaeology Field School In South Florida, Alanna L. Lecher, Katharine G. Napora, Sara Ayers-Rigsby, Malachi Fenn, Melissa Lehman, Peter De Witt, John Sullivan
Faculty and Staff Publications & Presentations
Entry into the profession of archaeology generally requires the completion of an archaeological field school, which teaches proper field, laboratory, and curation methodologies. Archaeology as a discipline has been making strides towards integrating cross-disciplinary methods to increase the depth and breadth of the subject and enhancing inclusivity. These efforts have been mirrored in the approaches of some archaeological field schools, but not necessarily in a systematic fashion. This paper presents a cohesive framework for an archaeological field school that integrates cross-disciplinary training and inclusivity by model of the United Nations Sustainable Development Goals (UN SDGs), specifically SDGs 11: Sustainable Cities …
Impaired Hydrogen Sulfide Biosynthesis Underlies Eccentric Contraction-Induced Force Loss In Dystrophin-Deficient Skeletal Muscle, W Michael Southern, Erynn E Johnson, Elizabeth K Fasbender, Katherine S Fallon, Courtney L Cavazos, Dawn A Lowe, George G Rodney, James M Ervasti
Impaired Hydrogen Sulfide Biosynthesis Underlies Eccentric Contraction-Induced Force Loss In Dystrophin-Deficient Skeletal Muscle, W Michael Southern, Erynn E Johnson, Elizabeth K Fasbender, Katherine S Fallon, Courtney L Cavazos, Dawn A Lowe, George G Rodney, James M Ervasti
Faculty, Staff and Students Publications
Eccentric contraction-induced (ECC-induced) force loss is a hallmark of murine dystrophin-deficient (mdx) skeletal muscle that is used to assess efficacy of potential therapies for Duchenne muscular dystrophy. While virtually all key proteins involved in muscle contraction have been implicated in ECC force loss, a unifying mechanism that orchestrates force loss across such diverse molecular targets has not been identified. We showed that correcting defective hydrogen sulfide (H2S) signaling in mdx muscle prevented ECC force loss. We also showed that the cysteine proteome of skeletal muscle functioned as a redox buffer in WT and mdx muscle during ECCs, but that buffer …
Sialylated Igg Induces The Transcription Factor Rest In Alveolar Macrophages To Protect Against Lung Inflammation And Severe Influenza Disease, Saborni Chakraborty, Derek E Byers, Philip A Mudd, Michael S Diamond, Et Al.
Sialylated Igg Induces The Transcription Factor Rest In Alveolar Macrophages To Protect Against Lung Inflammation And Severe Influenza Disease, Saborni Chakraborty, Derek E Byers, Philip A Mudd, Michael S Diamond, Et Al.
2020-Current year OA Pubs
While most respiratory viral infections resolve with little harm to the host, severe symptoms arise when infection triggers an aberrant inflammatory response that damages lung tissue. Host regulators of virally induced lung inflammation have not been well defined. Here, we show that enrichment for sialylated, but not asialylated immunoglobulin G (IgG), predicted mild influenza disease in humans and was broadly protective against heterologous influenza viruses in a murine challenge model. Mechanistic studies show that sialylated IgG mediated this protection by inducing the transcription factor repressor element-1 silencing transcription factor (REST), which repressed nuclear factor κB (NF-κB)-driven responses, preventing severe lung …
Animal Models Of Non-Respiratory, Post-Acute Sequelae Of Covid-19, Abigail Vanderheiden, Michael S Diamond
Animal Models Of Non-Respiratory, Post-Acute Sequelae Of Covid-19, Abigail Vanderheiden, Michael S Diamond
2020-Current year OA Pubs
Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes driven by dysfunction of multiple organ systems that can persist for years and negatively impact the quality of life for millions of individuals. We currently lack specific therapeutics for patients with PASC, due in part to an incomplete understanding of its pathogenesis, especially for non-pulmonary sequelae. Here, we discuss three animal models that have been utilized to investigate PASC: non-human primates (NHPs), hamsters, and mice. We focus on neurological, gastrointestinal, and cardiovascular PASC and highlight advances in mechanistic insight that have been made using these animal models, …
Helminth Infections Affect Host Immune Responses To Viral Infections And Vaccines, Juan García-Bernalt Diego, Pritesh Desai, Stephen T Yeung, Payal Damani-Yokota, Kamal M Khanna, Michael S Diamond, Michael Schotsaert
Helminth Infections Affect Host Immune Responses To Viral Infections And Vaccines, Juan García-Bernalt Diego, Pritesh Desai, Stephen T Yeung, Payal Damani-Yokota, Kamal M Khanna, Michael S Diamond, Michael Schotsaert
2020-Current year OA Pubs
Helminths are highly prevalent in many regions of the world. Due to the chronic nature of most helminth infections, these parasites are proficient immunomodulators of their hosts. This modulation often leads to skewed or even impaired immune responses against unrelated antigens, such as viruses and vaccines, which can be both beneficial and detrimental for the host. The extent of these effects and the impact on the outcomes of viral infection depends on a variety of factors including timing and tropism of both infections, pathological mechanisms, genetic background, and environmental factors. In this review, we dissect these complex interactions between virus …
Ard Es-Samra: A Protohistoric Settlement On The Outskirts Of The ‘Akko Plain / ארד א־סמרה: אתר יישוב פרוטו־היסטורי בשולי מישור עכו, Nimrod Getzov, Jacob Vardi, Nimrod Marom
Ard Es-Samra: A Protohistoric Settlement On The Outskirts Of The ‘Akko Plain / ארד א־סמרה: אתר יישוב פרוטו־היסטורי בשולי מישור עכו, Nimrod Getzov, Jacob Vardi, Nimrod Marom
Qadum: Journal of Excavation Reports from Israel
The excavation at Ard es-Samra revealed a protohistoric site covering an area of c. 200 dunams. Pottery and flint tools found at the site are attributed to a nearby Pre-Pottery Neolithic B–Pottery Neolithic settlement, while remains from the Early Chalcolithic III period suggest the existence of a small settlement at the site. Late Chalcolithic remains include evidence of cave dwellings, a flint knapping workshop and a hewn winepress—the oldest winepress uncovered in Israel to date. Early Bronze Age I remains include an EB IA burial cave and EB IB structures. Scant remains of structures and a rich assemblage of pottery …
The Effectiveness Of Augmented Reality Technology (Metaverse) On Mathematics Achievement Among Students With Learning Difficulties, Somaia Al-Nawaiseh
The Effectiveness Of Augmented Reality Technology (Metaverse) On Mathematics Achievement Among Students With Learning Difficulties, Somaia Al-Nawaiseh
Jordan Journal of Applied Science-Humanities Series
The study aimed to assess the effectiveness of using augmented reality (Metaverse) technology on the academic achievement in mathematics among fifth-grade students with learning difficulties in the Southern Al-Mazar district. An experimental approach was employed, utilizing an application based on augmented reality to teach a mathematics unit, along with an achievement test to evaluate the treatment's effects. A purposive sample of 60 male and female students with learning difficulties was used. After implementing the measurement tools during the academic year 2022/2023, where validity and reliability were verified through appropriate methods, statistically significant differences were observed between the means of the …
ʽAmqa: Faunal Remains From The Late Fatimid–Early Crusader Periods, Nimrod Marom
ʽAmqa: Faunal Remains From The Late Fatimid–Early Crusader Periods, Nimrod Marom
Qadum: Journal of Excavation Reports from Israel
This report analyzes faunal remains found in a building complex at ‘Amqa, primarily from the late Fatimid–early Crusader periods (eleventh–twelfth centuries CE). The assemblage consists mainly of cattle, sheep and goats, with a smaller number of camel, wild boar, equid, chicken and tortoise remains. Cattle bones, particularly from young individuals, are most prevalent, suggesting a focus on cattle rearing. Butchery marks indicate the use of tools for carcass processing, and bone fragmentation patterns suggest both intentional breakage and natural weathering. Comparisons with other sites from the same period highlight the unique predominance of cattle in ‘Amqa, possibly due to the …
ʽAmqa: Settlement Remains From The Iron Age, Hellenistic, Roman, Byzantine And Early Islamic Periods, Yardenna Alexandre, Michael Cohen
ʽAmqa: Settlement Remains From The Iron Age, Hellenistic, Roman, Byzantine And Early Islamic Periods, Yardenna Alexandre, Michael Cohen
Qadum: Journal of Excavation Reports from Israel
A salvage excavation at ‘Amqa, on the northern part of a hill located at the juncture of the ‘Akko coastal plain and the foothills of western Upper Galilee, revealed archaeological remains from the Pre-Pottery Neolithic, Iron II, Hellenistic, Roman, Byzantine, Early Islamic and Ottoman periods. Small excavation areas distributed over the hill exposed fragmentary architectural remains from Iron II, and a coastal pottery assemblage from the Hellenistic period. The Roman-period remains of a village included the walls of four buildings associated with Galilean pottery. Larger-scale Byzantine-period building remains, including a public building and a storage complex, as well as an …
Quality Criteria In Narrative And Script Writing For Children’S Television (Ages 0–6), Valerio Fuenzalida
Quality Criteria In Narrative And Script Writing For Children’S Television (Ages 0–6), Valerio Fuenzalida
Communication Research Trends
No abstract provided.
Unbeatable? Debates And Divides In Gender And Video Game Research, Carolyn Cunningham
Unbeatable? Debates And Divides In Gender And Video Game Research, Carolyn Cunningham
Communication Research Trends
No abstract provided.
Nonverbal Communication, Paul A. Soukup S.J.
Nonverbal Communication, Paul A. Soukup S.J.
Communication Research Trends
No abstract provided.
Parasocial Interactions And Relationships With Media Characters–An Inventory Of 60 Years Of Research, Nicole Liebers, Holger Schramm
Parasocial Interactions And Relationships With Media Characters–An Inventory Of 60 Years Of Research, Nicole Liebers, Holger Schramm
Communication Research Trends
No abstract provided.
Queen's Pride: A Queer Reading Of Star Wars Character Padmé Amidala, Madeleine Loewen
Queen's Pride: A Queer Reading Of Star Wars Character Padmé Amidala, Madeleine Loewen
Mythopoeic Society Seminar Proceedings
Ever since Luke Skywalker and Han Solo first appeared onscreen together in 1977, LGBTQ+ Star Wars fans have harnessed the power of queer reading to write themselves back into a galaxy far, far away, despite Lucasfilm’s long-term disapproval of such practices. Nonetheless, there exists little scholarly literature on queerness in the franchise, and even less on the potentially sapphic characters. Queen Padmé Amidala, first introduced onscreen in Episode I: The Phantom Menace, proves a surprising—but no less salient—queer figure in Star Wars. From her intimate relationships with her handmaidens, to her experimentation with gender performativity, to her quiet yet …
Trans Inequity, Intersectional Ritual, And Jewish Tikkun Olam (Healing Of The World), Valerie Estelle Frankel
Trans Inequity, Intersectional Ritual, And Jewish Tikkun Olam (Healing Of The World), Valerie Estelle Frankel
Mythopoeic Society Seminar Proceedings
As Jewish science fiction expands into twenty-first-century questions of identity, some authors explore the trans experience and build bridges towards intersectionality. Ritual and tradition become popular subjects. In the post-apocalyptic Fragments of the Brooklyn Talmud by Andrew Ramer, diverse rabbis create new prayers and practices. A Half-Built Garden by Ruthanna Emrys offers protagonists from a diverse commune who welcome aliens and rise up against the corporations. Bogi Takács’ short story “Three Partitions” questions where to segregate the shapeshifting Adira, and how the Orthodox space colony can change. Several of these stories ask how comfortable Jewish protagonists are with alien rituals …
The Mariner (And His Wife): Rethinking Aldarion's (A)Sexuality, Rory M. Queripel
The Mariner (And His Wife): Rethinking Aldarion's (A)Sexuality, Rory M. Queripel
Mythopoeic Society Seminar Proceedings
“Aldarion and Erendis” (Unfinished Tales) is a rare example in Tolkien’s work of a marriage gone severely awry. Many readings of the tale apportion blame to Aldarion, who is seen as “unwilling” to make the marriage work, and cruel and unfeeling towards Erendis, who herself is characterised as resentful and unaccepting. However, these readings rely on an assumption of a cisheteronormative and, more importantly, allosexual relationship between the couple. This paper proposes an alternate view of Aldarion and his role in the story, suggesting the possibility that he is asexual and/or aromantic (i.e., he does not experience sexual …
Myth, Murder, And Mayhem: Discerning The ‘Other’ In Our Flag Means Death, Sara Brown
Myth, Murder, And Mayhem: Discerning The ‘Other’ In Our Flag Means Death, Sara Brown
Mythopoeic Society Seminar Proceedings
Although the television series Our Flag Means Death presents on the surface as a romantic comedy, it is enhanced by mythic elements that infuse the narrative with a clear sense of the fantastic. Here, the pirates exist in a Secondary World that openly draws upon the Primary (both in terms of historiography and legend); hence 18th-century piracy and British colonialism can interact seamlessly with human-to-animal-transformations (paying homage to the Greek myth of Ceyx and Alcyone) without seeming either disconcerting or anomalous – all co-exist comfortably in Faerie. OFMD both inverts and deconstructs mythopoeia; the Primary World myths of the Gentleman …
Cruising Faërie: Further Notes On Queering Faith In Fantasy Literature, Taylor Driggers
Cruising Faërie: Further Notes On Queering Faith In Fantasy Literature, Taylor Driggers
Mythopoeic Society Seminar Proceedings
In Queering Faith in Fantasy Literature (2022), I argue that fantasy affords sexually marginalized people the ability to re-vision Christian theology in queer ways, thanks to its fixation on strange bodies, its longing for other worlds, and the ways in which both of these may reflect back on theological narratives of incarnation and salvation. Yet this project raises further questions that remain unresolved: namely, how might the framework of Christian theology constrain, as well as illuminate, queer imaginaries? If fantasy allows us to envision livable lives for ourselves as unruly bodies, just what forms of relating may those lives entail? …
Studying The Impact Of Weather Changes On Bird Breeding., Perle Suana, Yangyang Tao
Studying The Impact Of Weather Changes On Bird Breeding., Perle Suana, Yangyang Tao
Posters-at-the-Capitol
Climate change start to impact our daily life recently. The shifting climate introduces frequent and unpredictable temperature fluctuations. For species like birds, particularly those that reproduce through eggs, maintaining stable temperatures during incubation is crucial for reproductive success. Despite the significance of temperature stability, limited research has delved into understanding the thresholds of temperature tolerance during incubation. In this investigation, we will apply the data science tools to analyze the local temperature dataset over the past decade and the birds incubation dataset. Our aim was to explore potential correlations between extreme temperature swings coinciding with the breeding season and instances …
Bots, Paul A. Soukup S.J.
The Affordable Diy Mandeye Lidar System For Surveying Caves, And How To Convert 3d Clouds Into Traditional Cave Ground Plans And Extended Profiles, Loris Redovniković, Antun Jakopec, Janusz Będkowski, Jurica Jagetić
The Affordable Diy Mandeye Lidar System For Surveying Caves, And How To Convert 3d Clouds Into Traditional Cave Ground Plans And Extended Profiles, Loris Redovniković, Antun Jakopec, Janusz Będkowski, Jurica Jagetić
International Journal of Speleology
The paper examines the potential use of low-cost LiDAR for cave surveying. Mobile mapping using LiDAR complements traditional speleological surveying using a polygonal traverse. These methods assist each other, with one serving as an independent control measurement for the other, ultimately resulting in a more accurate 3D model. The testing results show that achieving high accuracy and detailed cave representation is possible using open hardware and open-source software. Both spacious and well-indented cave sections and narrow passages barely passable by humans were successfully mapped. The surveying process is significantly faster than traditional cave mapping, as drawing cave sketches by hand …
Comparative Analysis Of The Environmental Impact Of Biopolymer-Based And Conventional Plastic Packaging In Food Engineering Applications, Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie, Ogunyemi Ayobami Joshua, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Arthur Efeoghene Athan Essaghah
Comparative Analysis Of The Environmental Impact Of Biopolymer-Based And Conventional Plastic Packaging In Food Engineering Applications, Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie, Ogunyemi Ayobami Joshua, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Arthur Efeoghene Athan Essaghah
Al-Mustaqbal Journal of Sustainability in Engineering Sciences
The paper presents a comparative analysis of the environmental impacts of biopolymer-based packaging versus conventional plastic packaging in food engineering applications. It begins by highlighting the critical role of packaging in food preservation and safety, while addressing the environmental challenges posed by traditional plastic packaging, including pollution, waste accumulation, and the generation of microplastics. The review compares conventional plastics like PET and HDPE with biopolymers such as PLA and PHA, discussing the environmental advantages of biopolymers in terms of carbon footprint reduction, renewable resource utilization, and enhanced biodegradability. A life cycle assessment is employed to evaluate the resource usage, emissions, …
The Utah Statesman, January 13, 2025, Utah State University
The Utah Statesman, January 13, 2025, Utah State University
The Utah Statesman
Weekly student newspaper of Utah State University in Logan.
Exploring The Role Of Cyclin D1 In Regulating Thermogenic Program In Brown Adipose Tissue, Chengrui Qiu
Exploring The Role Of Cyclin D1 In Regulating Thermogenic Program In Brown Adipose Tissue, Chengrui Qiu
Biochemistry and Molecular Biology Scholarship
Adipose tissue plays a multifaceted role in regulating metabolic health and contributing to the pathophysiology of various diseases. Brown Adipose Tissue (BAT), a vital organ that senses different environment cues such as cold stress and diet and then undergoes non-shivering thermogenesis in mammalian animals, enhancing energy expenditure to combat obesity. In our recent published study, we found that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway exhibits doubleedge effects in regulating thermogenic function, with opposite role in BAT and white adipose tissue (WAT). To further investigate the molecular mechanisms underlying the dual role of mTORC1 in thermogenic regulation, …
Antibacterial And Antifungal Activities Of Linear And Cyclic Peptides Containing Arginine, Tryptophan, And Diphenylalanine, David Salehi, Eman H. M. Mohammed, Naiera M. Helmy, Keykavous Parang
Antibacterial And Antifungal Activities Of Linear And Cyclic Peptides Containing Arginine, Tryptophan, And Diphenylalanine, David Salehi, Eman H. M. Mohammed, Naiera M. Helmy, Keykavous Parang
Pharmacy Faculty Articles and Research
Background. We have previously reported peptides composed of sequential arginine (R) residues paired with tryptophan (W) or 3,3-diphenyl-L-alanine residues (Dip), such as cyclic peptides [R4W4] and [R4(Dip)3], as antibacterial agents. Results. Herein, we report antibacterial and antifungal activities of five linear peptides, namely ((DipR)4(WR)), ((DipR)3(WR)2), ((DipR)2(WR)3), ((DipR)(WR)4), and (DipR)4R, and five cyclic peptides [(DipR)4(WR)], [(DipR)3(WR)2], [(DipR)2(WR)3], [(DipR)(WR)4], and [DipR]5, containing alternate positively charged R and hydrophobic W and Dip residues against fungal, Gram-positive, and Gram-negative bacterial pathogens. The minimum inhibitory concentrations (MICs) of all peptides were determined by the micro-broth dilution method against Methicillin-Resistant Staphylococcus aureus, Klebsiella pneumoniae, …
Supporting Wildlife Restoration In Eastern States Via State Wildlife Action Plans, L. Mark Elbroch, John Vucetich, Christa Rose, Jeremy T. Bruskotter
Supporting Wildlife Restoration In Eastern States Via State Wildlife Action Plans, L. Mark Elbroch, John Vucetich, Christa Rose, Jeremy T. Bruskotter
Michigan Tech Publications
The biodiversity crisis is driven by extinction at two scales: the global extinction of species and the local extirpation of populations (i.e., range contraction). Local extirpations are especially acute in the eastern United States, which has lost a substantial portion of its native mammalian fauna. Species restoration in the U.S., therefore, should be utilised more to revitalise and restore degraded systems. State wildlife agencies can elevate discussions about species restoration and facilitate internal capacity to conduct restoration projects by including locally extirpated species in State Wildlife Action Plans, which are currently under revision, and will guide state conservation programs for …
Sentimental Aesthetics In D-Flat Major: Adagio Of Haydn’S Hob. Xvi:46, Keri Hui
Sentimental Aesthetics In D-Flat Major: Adagio Of Haydn’S Hob. Xvi:46, Keri Hui
HAYDN: Online Journal of the Haydn Society of North America
Although the concept of key characteristics was widely affirmed in the eighteenth century, the key of D-flat major was rarely adopted by composers. The so-called Romantic period, however, saw a remarkable increase in the use of this key, as demonstrated in the many well-known pieces written by composers such as Chopin. The article first reviews the different receptions of D-flat major in the eighteenth century and explores how the clavichord might have allowed Haydn to hear D-flat major as a key of sentimentality, one that echoes Christian Daniel Friedrich Schubart’s interpretation. It then examines ways in which Haydn presents the …
First In Time Since Time Immemorial: Tribal Instream Rights Undercut Water Taking Claims, Paul Stanton Kibel, L. Victoria Wang
First In Time Since Time Immemorial: Tribal Instream Rights Undercut Water Taking Claims, Paul Stanton Kibel, L. Victoria Wang
American Indian Law Journal
Courts have held that American Indian tribal fishery rights can give rise to tribal instream flow rights. They have also held that the curtailment of rights of diversion to protect fisheries under the Federal Endangered Species Act may give rise to potential takings claims under the Fifth Amendment of the United States Constitution. In its 2019 decision in Baley v. United States the federal circuit court of appeals held that minimum instream flows under the ESA were needed to fulfill American Indian tribal fishery rights, and these rights carried a priority date of “time immemorial” that was senior to any …
The Rhythms Of Our Bones, Thomas Henry Bowling
The Rhythms Of Our Bones, Thomas Henry Bowling
Online Theses and Dissertations
Grief is universal. It permeates all things. This collection is organized into four sections, each concerned with such universality, such permeability, and how the “small,” personal griefs of human relationships echo and form dialogues with the larger, more global griefs of war and violence. Ultimately, at the core of this collection, lies an investigation of family, masculinity, and how all griefs are absorbed and passed down by the generations that have preceded us.