Digital Commons Network^™

Investigating The Effects Of Cbd And Caffeine Interaction On Embryonic Development In Xenopus Laevis, Jeanesia M. Pierre

Theses

This study examined the interactive effects of cannabidiol (CBD) and caffeine on Xenopus laevis embryos over a 96-hour exposure period. Developmental toxicity was assessed using toxic unit isobole analysis, with LC₅₀, EC₅₀, and teratogenic index (TI) values calculated for CBD, caffeine, and mixtures at 3:1, 1:1, and 1:3 ratios.

Results showed that mixtures produced concentration-dependent interactions. When caffeine levels were higher, the mixtures displayed synergistic toxicity; as the proportion of CBD increased, the interaction shifted toward a concentration-addition model. Mortality was elevated in mixtures relative to single-compound exposures, while malformation rates decreased, indicating reduced teratogenicity. Overall, findings suggest that CBD …

Genome-Wide Identification Of Essential Genes For Microbial Insecticide Bioremediation, Mary Snook

AES Theses

Insecticides pose a threat to ecological, wildlife and human health when they are carried in runoff water from agricultural fields to surface and ground waters. Microbial bioremediation provides a promising avenue for degrading and removing these pollutants from runoff water before they dissipate into downstream ecosystems. While effective bioremediators for various target pesticides have been identified, we do not yet understand exactly how microbes degrade insecticides in most cases. In this study, I examined three bacterial strains with the ability to metabolize imidacloprid (strain Imidl Y) or malathion (strains Mal4 and Mal6), both common insecticides, and used transposon-mediated mutagenesis to …

Chapter 3: The Freezing Spell, Garon C. Smith

G. Wiz’s Book of Spells

The Freezing Spell is a fun one to pass off as a wizarding feat. A supersaturated solution of sodium acetate trihydrate is nucleated with seed crystals that the demonstrator has cleverly hidden on the tip of his/her middle finger. When the fingers are snapped over the open throat of the flask that holds the solution, a snowy hemisphere of crystallization grows over the next 10 seconds. The flask can then be inverted to show that it is now solid. The flask has also gone from room temperature to a nice handwarmer temperature of about 120^oF due to the …

Assessing The Role Of Ocean Literacy In Liberia's Blue Economy : Pathway To Sustainable Blue Ocean Development In Liberia, Precious Tete Nah

Ocean Sustainability, Governance & Management Dissertations

Ocean literacy involves understanding the fundamental concepts of the ocean's functioning, leading to informed and responsible decisions about the ocean. This understanding is vital for developing responsible ocean citizenship and implementing measures to sustain the ocean, as it highlights the ocean's influence on humans and the impact of human activities on it. Using a qualitative research method with a purposive sampling approach, the research asks focus group representatives from New Kru Town and Westpoint, both closed- and open-ended questions, on the importance of ocean literacy, challenges, prospects, and recommendations to promote sustainable blue ocean development.

The results of the research …

Cannabis Improves Metabolic Dysfunction And Macrophage Signatures In Obese Mice, Brandon N. Vanderveen, Thomas D. Cardaci, Christian A. Unger, Mitchell M. Nesmith, Jeffrey C. Freeman, Arianna V. Bastian, Kasie Roark, Mansi Upadhyay, Andrew G. Levy, Brooke M. Bullard, Sierra J. Mcdonald, Kandy T. Velázquez, Reilly T. Enos, Jason L. Kubinak, Lorne J. Hofseth Ph.D., James Hébert Scd, Daping Fan, E. Angela Murphy

Faculty Publications

Obesity rates continue to rise, highlighting the need for new treatments that are effective, safe, and widely accessible. Aligned with the easing of restrictions on cannabis use, interest in its therapeutic potential is evolving. As such, we examined the effects of the cannabis plant with high cannabidiol (CBD) content or high Δ9-tetrahydrocannabinol (THC) content on metabolic and immune dysregulation in obese mice. Briefly, female C57BL/6 mice were randomized into four groups (n = 15/group): 1) lean, 2) obese placebo, 3) obese CBD, and 4) obese THC. Lean mice consumed a low-fat diet for the study …

Numerical Simulations Of Highly Eccentric Systems Of Binary Neutron Stars With Spin, Victoria White

Harriet L Wilkes Honors College Theses

Binary Neutron Star (BNS) mergers are among the most energetic events in the universe, producing gravitational waves, electromagnetic radiation, and heavy elements. While previous research has utilized simulations for collisions, few studies have accounted for how the spin of the stars affects mergers. This thesis contains a general overview of the topic and a research component conducted in the field of numerical relativity. High-performance computing was used to simulate BNS collisions, examining how spin affects the inspiral, merger, and post-merger phases. Computations used the Einstein Toolkit, Cactus framework, and the numerical tool developed by the FAU Relativity Group, Sgrid. The …

Integrating Food Loss And Waste Reduction Policies With Global Dietary Shifts: An Economic Modelling Study, Alessandro Gatto, Maksym Chepeliev

Department of Agricultural Economics Faculty Publications

Background

Methods

A Translation Of Akira Mizubayashi's Reine De Coeur, Zachary N. Knudson-Swain

Department of Modern Languages and Literatures: Dissertations, Theses, and Student Research

Akira Mizubayashi's Reine de Coeur is a story about intergenerational trauma, and the ability music has to mend broken bonds. This translation is an attempt to bring the musicality of his language into English and convey Mizubayashi's unique cultural perspective in an English language context.

Advisor: Jordan Stump

A Better Great Plains: Bridging The Implementation Gap For A Better Future, David W. Sandahl

School of Natural Resources: Dissertations, Theses, and Student Research

The Northern Great Plains is experiencing extensive native grassland loss and landscape degradation, jeopardizing both ecological integrity and the socio-economic systems that rely upon these ecosystems. In an early effort to lessen degradation, the United States Department of Agriculture (USDA) introduced the Conservation Reserve Program (CRP) which generated ecosystem services benefits such as reduced soil erosion, improved water quality, and increased species diversity through the retirement of cropland and rangeland for 10- or 15-year contracts. However, CRP has not fully modernized alongside today’s agriculturalists and adoption remains shaped by an historically fraught socio-political context characterized by deep-seated mistrust between ranchers, …

Illuminated Magazine - Fall 2025, School Of Graduate Studies, East Tennessee State University

Illuminated: Graduate Student Research Magazine

• 2: Editorial Staff
• 5: Graduate Students and Advisors
• 6: ETSU’s First Master of Music Cohort Finds Its Voice on Campus
• 9: Where Are They Now? Jacob Mitchell
• 10: Characterizing and Enhancing Carotenoid Production in Tomato Plants
• 14: Where Are They Now? Jeremiah J. Flake
• 15: In the Gaps of the System: Centering BIPOC Mothers in Maternal Mental Health
• 18: Roles of Female Musicians in Appalachian Bluegrass
• 20: Where Are They Now? Alexis Moser
• 21: From Guyana to Tennessee: Bridging Gaps in Women’s Mental Health Care
• 24: Where Are They Now? Megan Roberts
• 26: Characterizing User Experience in AI Chatbots within …

Nutrition In Context: How Cultural Beliefs, Gender Norms, Social Environments, And Interventions Shape Maternal Nutrition In Nepal, Rebecca Fan

Switzerland: Global Health and Development Policy

Maternal nutrition is recognized as one of the most significant and modifiable determinants of persistent inequities in maternal and neonatal health. In Nepal, what women are able to eat and how they experience pregnancy are all shaped by a complex interplay of cultural beliefs, gendered expectations, household dynamics, structural barriers, and nutrition intervention efforts. This study examines these intersecting factors through ethnographic accounts, peer-reviewed scientific literature, expert interviews, and an analysis of current interventions operating across different levels. Specifically, to understand the social environments shaping maternal nutrition, the paper explores cultural beliefs and misconceptions surrounding food, women’s limited control over …

Strategic Leadership In Security Media: Enhancing Community Safety Against Drug Abuse In Oman, Raed Awashreh, Saif Alshuhoomi,, Viola Gjylbegaj

Journal of Strategic Security

Rapid global development has led to increased security challenges, particularly regarding drug-related crimes. This study examines the role of strategic leadership in security media to enhance community security, focusing on drug abuse in Oman. Despite ongoing efforts to combat drug-related offenses, these crimes remain a significant threat to societal stability. The qualitative research involved in-depth interviews with 14 decision-makers, including 7 experts from Oman’s security media, police, and related institutions. It explores the effectiveness of security media campaigns in raising awareness and reducing drug use. Thematic analysis of the data revealed key challenges, including limited resources, outdated technologies, and insufficient …

'In A Mirror, Dimly, Then Face To Face:' Reflecting On Bodily Sin And Spiritual Purity In The Central Female Figures Of Hugo Van Der Goes' Vienna Diptych, Sara Kluka

Theses

This thesis seeks to examine the so-called Vienna Diptych (1478/1479) by Hugo van der Goes. The two panels of the diptych have been displayed together since the 19th century, yet difficulties in provenance and the dating of the artist’s oeuvre have resulted in the continued questioning of its intended creation as a single campaign. This research seeks to assert the diptych’s thematic unity through a concentrated analysis of its leading female figures, a vantage point that has not yet been fully addressed in the literature. This paper will therefore examine the iconographic precedents for the unique imagery of the panels …

Ambiguous Bodies: Third Gender Expressions In Ancient Maya Art, Jayme Horne

Theses

This thesis examines the interpretations of Lintels 23, 24, and 25 from Yachilán, Drawing 18 from Naj Tunich, and Stela H from Copán, with a specific focus on third gender expression. These artworks depict figures that blend masculine and feminine attributes, from costuming to actions, to present intentionally ambiguous representations of the body that all ancient Maya people would have understood. Third gender expression is defined through the blending of masculine and feminine signifiers. It is a gender identity for people who do not identify as male or female, but rather as neither, both, or a combination of male and …

Draft Card Battler, Brian Moore

Theses

This project investigates how design transparency and player interaction mechanics can enhance emotional connection and strategic depth in competitive digital card game environments. Draft Card Battler transforms traditional sequential turn-based Trading Card Game (TCG) gameplay into a structured round-based system featuring asymmetric card-play patterns (1-2-2-1) and simultaneous combat resolution. Beginning with a physical card game prototype, the project evolved through iterative design and digital implementation, informed by research in social capital theory and player psychology. Through reflective playtesting and technical development, this study explores whether visibility, pacing, and commitment mechanics foster trust, fairness, and cooperation alongside competitive tension. The implementation …

Investigating The Effect Of Gene Ncu07872 Deletion On Spore Killing By Neurospora Sk-3, Allison Rimmey

Senior Theses – Biological Sciences

The selfish genetic element Spore killer-3 (Sk-3) is found in some Neurospora fungi. Sk-3 is considered selfish because it has evolved the capacity to bias its transmission to the next generation through spore killing. The mechanism of spore killing requires at least two genes, a gene that produces a resistance protein (an antidote) and a gene that produces a killer protein (a poison). The Sk-3 genetic element is millions of base pairs long and contains hundreds of genes. Although the antidote gene has been identified, the identity of the poison gene has remained elusive. Previous research has identified a DNA …

Not Born A Democracy: Constitutional Preconditions, Martha Minow

William & Mary Law Review

Beneath growing perceptions of constitutional crisis and democratic fragility in the United States lies a fundamental conundrum. Critical preconditions for effective self-government are either weak or missing in action, and our constitutional system, at least for now, stands in the way of actions to strengthen or build those preconditions. This Article focuses on three essential predicates for constitutional democracy that face jeopardy: education, reliable news, and security against lethal violence. As basic as these elements may be, repeated efforts to secure a federal constitutional right to education have failed in the courts. Because of a confluence of legal, technological, and …

Mckee Minute October 2025, Southern Adventist University

McKee Minute – McKee Library This Month

The October 2025 edition of McKee Minute includes information on International Open Access Week, National Book Month, course reserves, and the library's mid-semester break hours.

Curricular Choices: Misconceptions Regarding Law School Courses, Constance Backhouse, Holland Stille, Avery Esford

Dalhousie Law Journal

Canadian law schools offer their upper-year students a wealth of optional curricular choices. Yet many students choose narrowly and poorly. This article addresses the misconceptions that many hold as they select their second- and third-year courses. Often students believe they need certain courses to get a job, to prepare for articling, to pass the bar exams, or to prepare for future legal careers. In most cases, these concerns are erroneous. This article urges students to choose based on factual evidence rather than imagined anxieties and on personal interest rather than the “group think” rigidity that infects much of the curricular …

Border Decriminalization As A State Project: Lessons From Marijuana And Assisted Suicide Legalization Across The United States, Victor C. Romero

William & Mary Journal of Race, Gender, and Social Justice

My prior work argued for the decriminalization of border crossings without proof of specific intent to violate another law (like drug trafficking), which is even less likely to happen now than it was when the piece was published, given the current presidential administration’s zealous deportation strategy and Congress’s seeming acquiescence. As such, I advocate for a second-best solution involving federal-state cooperative agreements wherein border states abutting both Mexico and Canada are given the option by the federal government to pass local legislation decriminalizing border crossings into their states as their communities desire. To the extent that the current presidential administration …

The Demonization Of America's Economic Engine, Ediberto Roman

William & Mary Journal of Race, Gender, and Social Justice

In a 2013 book entitled Those Damned Immigrants: America’s Hysteria Over Undocumented Immigration, I warned of a conservative political trend that I believed would lead to an all-out assault on undocumented immigrants. This trend occurred despite the fact that these immigrants are critical economic boons to our economy.

On his first day in office in 2025, President Trump made the book’s warnings prophetic. That day, President Trump issued a series of executive orders, including 10 focused on limiting entry into the United States and questioning many who previously entered the United States legally. These orders include, 1) enhanced deportation …

Beyond Democracy: How A Free Press Supports The Rule Of Law, Erin C. Carroll

Georgetown Law Faculty Publications and Other Works

Widespread agreement has existed for centuries that a free press is essential to democracy. But legal scholars have spent almost no effort thinking about why else we might need a free press. This article attempts to widen the aperture. It argues that as the free press is essential to democracy, it is just as essential to a separate value: the rule of law.

Recognizing and investigating the connections between the free press and the rule of law is essential right now. It can help us discern how the press can create friction against the erosion of both rule of law …

Exploring Undergraduate Early Childhood Education Students' Conceptualizations Of Stem In Early Learning Contexts, Melany Spiehs

Educational Leadership Theses, Dissertations, and Student Creative Activity

Early childhood is widely recognized as a critical stage for STEM (science, technology, engineering, and mathematics) learning, yet many teachers feel underprepared to support children’s foundational knowledge and skills. This study examines how undergraduate students in early childhood education conceptualize STEM within early learning environments through an analysis of their coursework and field experiences. The investigation explores both students’ articulated beliefs about STEM (espoused theories) and how they enacted STEM teaching and learning in practice (theories-in-use). Data were drawn from course artifacts including journals, reflections, learning stories, lesson plans, and field observation notes. While much of the existing literature emphasizes …

Venturing Into Health, Rachel E. Sachs

Fordham Law Review

In recent years, the landscape of venture capital (VC) investment in healthcare technologies has been altered by the introduction of new types of VC firms: those that have emerged from hospital systems and health insurers. However, the legal literature has not yet analyzed these new VC firms, the role they may play in healthcare innovation, and how innovation law and policy ought to consider their involvement. Hospital system and health insurer VC firms operate very differently than traditional VC firms, even those that have historically developed healthcare specializations. Instead of simply investing capital into start-up firms, hospital system and health …

Table Of Contents (V. 50, No. 1)

William & Mary Environmental Law and Policy Review

No abstract provided.

Subsistence As Resistance: Reconceptualizing The Theory Of Progressive Property To Incubate Resistance To Consumerism, D.S. Pensley

William & Mary Environmental Law and Policy Review

This Article reconceptualizes the theory of progressive property by juxtaposing legal theory with the empirical study of a subsistence economy in the U.S. Subarctic. Progressive property holds that owners are bound by obligations to non-owners as a means to achieve human flourishing. The theory is constrained by the primacy of private property in Western thought, and it also lacks the ecological ethic required for sustainability. Drawing from my fieldwork, I suggest that human flourishing must additionally incubate resistance to consumerism.

Federal statute, 16 U.S.C. § 3113, defines subsistence as “the customary and traditional uses by rural Alaska residents of wild, …

Let's Bee Pragmatic: The Economic Case For Neonicotinoid Regulation In Conservative States, Annie Rosenstein

William & Mary Environmental Law and Policy Review

The importance of bees in our ecosystem and to our food system in the United States cannot be overstated. In fact, 35% of global crop production depends on bees and other pollinating insects. Pollinators not only influence the production of many foods that we hold dear and rely on, such as apples, chocolate, potatoes, and coffee, but also influence the quality of these products.

Currently, the most insidious threat against bees in the United States is neonicotinoid pesticides (neonics). While neonics are effective at killing the target populations of beetles, aphids, and flies, they are equally effective at killing pollinators, …

From Disruption To Renewal: Harnessing Divine Interruptions And Strategic Leadership For Transforming Church Culture, Ryan Johnson

Great Commission Research Journal

Church revitalization is a field that addresses refreshing the church’s mission and vision by leaders who assess internal and external factors affecting the congregation’s current state. However, researchers in organizational culture argue that refreshed strategies will be ineffective without also addressing underlying cultural issues. This essay addresses the need for and the process of transforming church culture during the revitalization process. Pastors and leaders bring about cultural change by disrupting the status quo. This disruptive leadership is achieved through two approaches. First, leaders proactively and incrementally disrupt the status quo to influence cultural change through faithful pastoral practices. Secondly, leaders …

Fall 2025 Complete Issue, David R. Dunaetz

Great Commission Research Journal

No abstract provided.

Proteomic Approaches To Investigate Pp2a-B55 Substrates And Cellular Function, Brennan C. Mcewan

Dartmouth College Ph.D Dissertations

Cell division is controlled in large part by reversible protein phosphorylation. The phosphorylation state of proteins during mitosis and other phases of the cell cycle represents a careful balance of activity between kinases and opposing phosphatases. The phosphoprotein phosphatase (PPP) family is responsible for the majority of serine and threonine dephosphorylation. Members of the PPP family are composed of a catalytic subunit paired with a regulatory subunit that targets them towards specific substrates.

The most abundant PPP, PPP2A, paired with its regulatory B55 subunit, is thought to be the phosphatase responsible for the dephosphorylation of substrates during mitotic exit. Despite …