Digital Commons Network^™

Experimental Investigation And Operating Characteristics Of Lhr Engine Using Bio-Fuel Blends With Additives, Suresh R

Theses and Dissertations

The huge energy demand and environmental anxiety are the reasons for the focus on the interest in alternative fuels for diesel engines. This has resulted in a worldwide search for renewable, less pollutant and agricultural-based alternate fuels. Also, attention is given to increasing the efficiency of a conventional diesel engine when operating on alternative fuels. The bio-fuel derived from non-edible oil such as Pongamia oil and Neem seed oil are suggested alternative fuels for this LHR engine.

Diesel engine combustion components viz., the piston crown and liner were coated with Aluminium Titanate thermal barrier coating material. The objective of this …

Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta

Faculty Scholarship

Platelets, traditionally known for their role in hemostasis, have emerged as key players in immune response and inflammation. Sepsis, a life-threatening condition characterized by systemic inflammation, often presents with thrombocytopenia, which at times, can be significant. Platelets contribute to the inflammatory response by interacting with leukocytes, endothelial cells, and the innate immune system. However, excessive platelet activation and consumption can lead to thrombocytopenia and exacerbate the severity of sepsis. Understanding the multifaceted roles of platelets in sepsis is crucial for developing effective therapeutic strategies. Targeting platelet-mediated inflammatory responses and promoting platelet production may offer potential avenues for improving outcomes in …

Swine Origin Probiotics That Promote Health And Growth Performance In Pigs, Jiangchao Zhao, Xiaofan Wang, Tsung Cheng Tsai, Charles V. Maxwell

Patents Granted

The present invention provides probiotic compositions comprising isolated bacterial strains, referred to herein as LactX, StrepX1 and StrepX3. Methods of using the compositions to increase growth rate in pigs and enhance pig production are also provided.

Exploring Genetic Diversity: The Inheritance Of Protein And Mineral Contents In Dwarf Common Beans, Ercan Ceyhan, Ayşegül Korkmaz, Amjad Ali̇, Serdar Karadaş, Mustafa Harmankaya, Duran Şi̇mşek, Tolga Karaköy

Turkish Journal of Agriculture and Forestry

Beans are a vital plant-based protein, containing essential minerals that are necessary for human health. Their protein and mineral compositions vary due to factors including cultivar or variety, growth conditions, and processing methods. Global deficiencies in protein and minerals necessitate fortification, supplementation, and dietary diversification. The present study focuses on common bean (Phaseolus vulgaris) cultivars, aiming to understand their genetic variation and inheritance of protein and mineral contents. Five dwarf common bean cultivars (Lida, Beyzade, Ribera, Albeni, and Garrafol) were used in a full-diallel hybridization method and the experiment was conducted in Konya, Türkiye. The diallel analysis assessed both general …

Nutritional And Microbiological Properties Of Cheese With Dried Elderberry And Red Grape Pomace, Andreea Dodan, Romina Alina Marc, Crina Carmen Mureşan, Carmen Rodica Pop, Delia Michiu, Miuța Rafila Filip, Roxana Nicoleta Rațu, Florina Stoica, Ioana Cristina Crivei, Alina Narcisa Postolache, Melinda Kovacs, Rodica Maria Sima, Mircea Valentin Muntean

Turkish Journal of Agriculture and Forestry

This study aimed to explore the use of grape byproducts such as red grape pomace and elderberry, in the form of bioactive powders to obtain three-month old cheese assortments. Grape pomace powder (GPP) and elderberry fruit powder (EFP) contain antioxidant components such as phenols, anthocyanins and flavonoids, and compounds characterized by high bioactivity. This study investigated not only the potential of incorporating different percentages (1%, 2%, and 3%) of GPP and EFP in cheese, to increase its nutritional value, but also the changes that occur during the 2 months of ripening. The results indicated that the incorporation of GPP and …

Repeat Expansion In A Fragile X Model Is Independent Of Double Strand Break Repair Mediated By Pol Θ, Rad52, Rad54 Or Rad54b, Bruce E Hayward, Geum-Yi Kim, Carson J Miller, Cai Mccann, Megan G Lowery, Richard D Wood, Karen Usdin

Faculty, Staff and Student Publications

Microsatellite instability is responsible for the human repeat expansion diseases (REDs). The mutagenic process differs from classical cancer-associated microsatellite instability (MSI) in that it requires the mismatch repair proteins that normally protect against MSI. LIG4, an enzyme essential for non-homologous end-joining (NHEJ), the major pathway for double-strand break repair (DSBR) in mammalian cells, protects against expansion in mouse models. Thus, NHEJ may compete with the expansion pathway for access to a common intermediate. This raises the possibility that expansion involves an NHEJ-independent form of DSBR. Pol θ, a polymerase involved in the theta-mediated end joining (TMEJ) DSBR pathway, has been …

Engineered Immunomodulatory Extracellular Vesicles From Epithelial Cells With The Capacity For Stimulation Of Innate And Adaptive Immunity In Cancer And Autoimmunity, Xin Luo, Fernanda G Kugeratski, Dara P Dowlatshahi, Hikaru Sugimoto, Kent A Arian, Yibo Fan, Li Huang, Danielle Wills, Sergio Lilla, Kelly Hodge, Sara R Zanivan, Valerie S Lebleu, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are generated by all cells. Systemic administration of allogenic EVs derived from epithelial and mesenchymal cells have been shown to be safe, despite carrying an array of functional molecules, including thousands of proteins. To address whether epithelial cells derived EVs can be modified to acquire the capacity to induce immune response, we engineered 293T EVs to harbor the immunomodulatory molecules CD80, OX40L and PD-L1. We demonstrated abundant levels of these proteins on the engineered cells and EVs. Functionally, the engineered EVs efficiently elicited positive and negative co-stimulation of human and murine T cells. In the setting of …

Nprl2 Gene Therapy Induces Effective Antitumor Immunity In Kras/Stk11 Mutant Anti-Pd1 Resistant Metastatic Non-Small Cell Lung Cancer (Nsclc) In A Humanized Mouse Model, Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth J Shpall, Jack A Roth

Faculty, Staff and Student Publications

Expression of NPRL2/TUSC4, a tumor-suppressor gene, is reduced in many cancers including NSCLC. Restoration of NPRL2 induces DNA damage, apoptosis, and cell-cycle arrest. We investigated NPRL2 antitumor immune responses in aPD1R/KRAS/STK11^mt NSCLC in humanized-mice. Humanized-mice were generated by transplanting fresh human cord blood-derived CD34 stem cells into sub-lethally irradiated NSG mice. Lung-metastases were developed from KRAS/STK11^mt/aPD1R A549 cells and treated with NPRL2 w/wo pembrolizumab. NPRL2-treatment reduced lung metastases significantly, whereas pembrolizumab was ineffective. Antitumor effect was greater in humanized than non-humanized-mice. NPRL2 + pembrolizumab was not synergistic in KRAS/STK11^mt/aPD1R tumors but was …

Complete Genome Sequence Of A Penicillin-Resistant Fusobacterium Necrophorum Subsp Funduliforme Isolate From A Tonsillitis Patient, Bibek G C, Anders Jensen, Chenggang Wu

Faculty, Staff and Student Publications

We report the complete genome sequence of a penicillin-resistant Fusobacterium necrophorum subsp. funduliforme isolate, AJ79, from a tonsillitis patient. The AJ79 genome consists of a chromosome (2,440,359 bp) and plasmid (9,887 bp), providing insights into the genetic basis of penicillin resistance in F. necrophorum and its implications for treating tonsillitis.

Bbox1 Restrains Tbk1-Mtorc1 Oncogenic Signaling In Clear Cell Renal Cell Carcinoma, Chengheng Liao, Lianxin Hu, Liwei Jia, Jin Zhou, Tao Wang, Kangsan Kim, Hua Zhong, Hongwei Yao, Lei Dong, Lei Guo, Qian Liang, Cheng Zhang, Fangzhou Zhao, Jun Fang, Hongyi Liu, Shina Li, Lin Xu, Jeremy M Simon, Srinivas Malladi, Payal Kapur, James Brugarolas, Ralph J Deberardinis, Qing Zhang

Faculty, Staff and Student Publications

Clear cell renal cell carcinoma (ccRCC), a metabolic disease originating from renal proximal convoluted tubule (PCT) epithelial cells, remains incompletely understood in terms of its initiating signaling events. Here, we identify γ-butyrobetaine hydroxylase 1 (BBOX1), a key enzyme in carnitine synthesis predominantly expressed in PCT cells, as a tumor suppressor in ccRCC. BBOX1 expression is lost during ccRCC malignant transformation, and its restoration reduces cell viability in physiological medium and inhibits xenograft tumor growth. Transcriptomic analyses reveal that BBOX1 suppresses critical metabolic pathways including mTORC1 signaling and glycolysis in ccRCC. Further, we identify TANK-binding kinase 1 (TBK1) as an essential …

The Tie2 Antagonist Rebastinib Reduces Ovarian Cancer Growth In A Syngeneic Murine Model, Vijayalaxmi G Gupta, Katherine F Roby, Harsh B Pathak, Andrew K Godwin, Sumedha Gunewardena, Dineo Khabele

2020-Current year OA Pubs

BACKGROUND: The receptor tyrosine kinase TIE2 and its ligands, angiopoietins (ANGPTs), promote angiogenesis. In addition to expression on vascular endothelial cells, TIE2 is expressed on M2-like pro-tumorigenic macrophages. Thus, the TIE2 inhibitor rebastinib was developed as a potential therapy to address multiple cancers. The objective of this study was to determine the effects of rebastinib alone and combined with chemotherapy in a syngeneic murine model of ovarian cancer.

METHODS: Female C57Bl6J mice were intraperitoneally injected with syngeneic ID8 ovarian cancer cells. Once tumors were established, mice were untreated (control) or treated with rebastinib, carboplatin plus paclitaxel (chemotherapy), or rebastinib plus …

Restore The Shore: A Guide To Lakeshore Revegetation In The Great Basin, Jes V. Braun, Rae Robinson, Annie L. Henry, Karin M. Kettenring

All Current Publications

Lakeshore vegetation supports many valuable aspects of lake ecosystems: foraging areas for birds, rearing grounds for fish, nutrient cycling, carbon storage, and aesthetic, cultural, and spiritual values. Yet, the vegetation of many lakeshores has been lost or heavily impacted by humans. What can be done to restore lakeshore vegetation to ensure that lakes remain healthy for future generations? In this guide, we summarize best practices for lakeshore revegetation (i.e., the process of actively reintroducing vegetation, usually native species, to a restoration site through seeding and planting) in the Great Basin.

Updated Sc 4-H Presents Packet, Extension

UNH Cooperative Extension

No abstract provided.

Phosphorylation Of Cryab Induces A Condensatopathy To Worsen Post-Myocardial Infarction Left Ventricular Remodeling, Moydul Islam, David R. Rawnsley, Xiucui Ma, Walter Navid, Chen Zhao, Xumin Guan, Layla Foroughi, John T. Murphy, Honora Navid, Carla J. Weinheimer, Attila Kovacs, Jessica Nigro, Aaradhya Diwan, Ryan P. Chang, Minu Kumari, Martin E. Young, Babak Razani, Kenneth B. Margulies, Mahmoud Abdellatif, Simon Sedej, Ali Javaheri, Douglas F. Covey, Kartik Mani, Abhinav Diwan

2020-Current year OA Pubs

Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role in more prevalent heart-failure syndromes remains mechanistically unexamined. We observed mislocalization of desmin and sarcomeric proteins to aggregates in human myocardium with ischemic cardiomyopathy and in mouse hearts with post-myocardial infarction ventricular remodeling, mimicking findings of autosomal-dominant cardiomyopathy induced by the R120G mutation in the cognate chaperone protein CRYAB. In both syndromes, we demonstrate increased partitioning of CRYAB phosphorylated on serine 59 to NP40-insoluble aggregate-rich biochemical fraction. While CRYAB undergoes phase separation to form condensates, the phosphomimetic mutation of serine 59 …

Formulation, Characterization, And In Vitro–In Vivo Evaluation Of Self Microemulsifying Drug Delivery System Of Ebastine By Spray Drying Technology Using Solid Carriers, Vijay Rajaram Mahajan, Ganesh Dinkarrao Basarkar

The Thai Journal of Pharmaceutical Sciences

Aim: The present work was aimed at formulating novel liquid self microemulsifying oil formulation and its solid form by spray drying method for improving the solubility of Ebastine, an antiallergic drug and BCS class II drug, evaluating its in vitro and in vivo potential. Results: The self emulsifying oil formulation was comprised of Rice Bran Oil, Tween 40, Capryol 90. Pseudoternary phase diagrams were used to evaluate the micro emulsification existence area, and the release rate of Ebastine was investigated using an in vitro dissolution test. Accelerated stability testing of the formulation was also assessed at 400C/75% RH for 3 …

Antidepressant-Like Effect Of Minocycline In Mice Forced Swimming Test: Minor Involvement Of The Noradrenergic System, Azadeh Mesripour, Mohsen Kavianpour, Valiollah Hajhashemi

The Thai Journal of Pharmaceutical Sciences

Introduction: Minocycline is a tetracycline antibiotic drug that is receiving attention as an alternative for the treatment of depression. Several mechanisms have been proposed for this effect. The current study evaluated the involvement of the noradrenergic system in the antidepressant-like effect of minocycline. Materials and Methods: The total immobility time was evaluated as an index of depression in mice forced swimming test (FST). Minocycline (40 mg/kg) was injected for 3 days. Imipramine (5 mg/kg, a tricyclic antidepressant), prazosin (1 mg/kg, an α1-adrenoceptor antagonist), yohimbine (1 mg/kg, an α2-adrenoceptor antagonist), and propranolol (2 mg/kg, a β-adrenoceptor antagonist) were injected 30 min …

Use Of Synthetic Water-Soluble Kcc2 To Modulate Chloride Homeostasis In Cultured Dopamine-Neuron-Like Cells, Mason Terry, Andrew Payne, Dario Mizrachi

Annual Research Symposium

No abstract provided.

Religious Moral Suasion And Material Support For The Environmental Justice Movement, Sarah Elizabeth Nahar

International Journal on Responsibility

The Environmental Justice (EJ) movement in the United States is comprised of diverse groups of people with a variety of environmental grievances and interests coming together to obtain equal distribution of pollution burdens across communities, reduce environmental hazards, and ensure fair enforcement of laws and policies meant to safeguard the environment for all. The 17 Principles of Environmental Justice developed in 1991 at the First National People of Color Environmental Leadership Summit remains a touchstone document today. In addition to Indigenous and Black leadership, religious communities also made the Summit possible. Religious adherents and institutions have always influenced the movement …

Complete Issue - Mend (Spring 2025), Mend Journal

Mend

No abstract provided.

Running, Sergey Medvedev

Mend

No abstract provided.

The Fall, Dymitri Hubert Haraszewski

Mend

No abstract provided.

Falling, Michael Shane Hale

Mend

No abstract provided.

Pavlov's Dogs, Gary K. Farlow

Mend

No abstract provided.

Section Ii: Listen Up!, Marion Rodriguez, Patrick W. Berry

Mend

No abstract provided.

Time And Prison: Are They Mutually Exclusive?, Marvin Wade

Mend

No abstract provided.

Characterization Of 1,8-Cineole (Eucalyptol) From Myrtle And Its Potential Antibacterial And Antioxidant Activities*, Humera Khan

Karbala International Journal of Modern Science

1,8-Cineole is a naturally occurring chemical molecule predominantly found in fragrant plants, particularly Myrtle. Its aroma is distinctive and has been the subject of numerous investigations due to its various biological actions. This study examines the characterization of 1,8-Cineole derived from Myrtle and investigates its antibacterial and antioxidant properties. This study seeks to compare 1,8-Cineole with antibiotics like Amoxicillin and Tetracycline, and moreover, to investigate its antioxidant capabilities against diverse bacterial strains (both Gram-positive and Gram-negative). 1,8-Cineole exhibits the most effective antibacterial properties, demonstrating an inhibition zone of 12.00 mm against Staphylococcus aureus and 10.00 mm against Pseudomonas aeruginosa. …

Impact Of Resistance Training On Bone During 40% Caloric Restriction In Growing Female Rats, Ken D. Sumida, Daniel L. Smithers, Aaron Gerston, Kim A. Lagerborg, S. Victoria Jaque, Fred Caporaso

Food Science Faculty Articles and Research

There is a growing trend in the use of severe caloric restrictive diets among normal weight young females that can jeopardize bone health. Using an animal model, the purpose of this study was to determine whether resistance training (RT) could maintain bone health during a 6-week severe caloric restrictive (CR) diet in growing female rats. Twenty-four female rats (~ 8 weeks old) were randomly divided into the following groups: sedentary rats fed a normal diet (N = 8), sedentary rats fed a 40% CR diet (D = 8), and an RT group fed a 40% CR diet (DT …

Curricular Changes Proposed For 2025-2027 Morris Catalog, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

The Joy Of Embodied Learning, Leslie Bayers

Academic Affairs Faculty and Staff Books and Book Chapters

The science of embodied cognition has established that thinking involves dynamic exchanges between the body and the brain and webs of interaction between humans and their environments. While learning draws on these connected ecosystems, persistent notions of the brain as separate from and hierarchically managing the body—an enduring legacy of Cartesian dualism—perpetuate static teaching and learning mindsets. Disregard for the body’s role in learning fuels disengagement, isolation, and inequity. This chapter weaves key findings from embodied learning research together with scenes from the author’s own academic journey to illustrate how leveraging brain–body connections can foster educational well-being. The author shares …

The Rider (2025-02-10), Rebeca Salinas

The Rider Archives

Vol. 10, No. 18