Digital Commons Network^™

Long-Read Sequencing Of 945 Han Individuals Identifies Structural Variants Associated With Phenotypic Diversity And Disease Susceptibility, Jiao Gong, Huiru Sun, Kaiyuan Wang, Yanhui Zhao, Yechao Huang, Qinsheng Chen, Hui Qiao, Yang Gao, Jialin Zhao, Yunchao Ling, Ruifang Cao, Jingze Tan, Qi Wang, Yanyun Ma, Jing Li, Jingchun Luo, Sijia Wang, Jiucun Wang, Guoqing Zhang, Shuhua Xu, Feng Qian, Fang Zhou, Huiru Tang, Dali Li, Chinese Pangenome Consortium (Cpc), Fritz J Sedlazeck, Li Jin, Yuting Guan, Shaohua Fan

Faculty, Staff and Students Publications

Genomic structural variants (SVs) are a major source of genetic diversity in humans. Here, through long-read sequencing of 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many with predicted functional importance. By integrating human population-level phenotypic and multi-omics data as well as two humanized mouse models, we demonstrate the causal roles of two SVs: one SV that emerges at the common ancestor of modern humans, Neanderthals, and Denisovans in GSDMD for bone mineral density and one modern-human-specific SV in WWP2 impacting height, weight, fat, craniofacial phenotypes and immunity. Our results suggest that the GSDMD SV could …

Hemodynamics Of Slip Surfaces For Thrombosis Control In Implanted Cardiovascular Devices, Kieun Choi, Weiguang Yang, On Shun Pak, Jongmin Seo

Mechanical Engineering Faculty Publications

Percutaneous medical devices are preferred for the treatment of cardiovascular diseases due to their minimal intervention compared to surgery. However, complications such as thrombosis remain significant challenges. This study aims to investigate the hemodynamic effects of slip surfaces on pacemaker leads and coronary stents using computational fluid dynamics under physiological conditions. Two computational models were developed: a venous anatomical model with a pacemaker lead and a coronary artery model with a stent. Slip boundary conditions were applied to these devices, and we quantitatively analyzed critical hemodynamic parameters, including wall shear stress (WSS) and residence time (RT), which are associated with …

Transhumanism And Artificial Personality, John D. Mayer

UNH Personality Lab

No abstract provided.

Neuronal Network Activation Induced By Forniceal Deep Brain Stimulation In Mice, Bin Tang, Zhenyu Wu, Qi Wang, Jianrong Tang

Faculty, Staff and Students Publications

Background: The fimbria-fornix is a nerve fiber bundle that connects various structures of the limbic system in the brain and plays a key role in cognition. It has become a major target of deep brain stimulation (DBS) to treat memory impairment in both dementia patients and animal models of neurological diseases. Previously, we have reported the beneficial memory effects of chronic forniceal DBS in mouse models of intellectual disability disorders. In Rett syndrome and CDKL5 deficiency disorder models, DBS strengthens hippocampal synaptic plasticity, reduces dentate inhibitory transmission or increases adult hippocampal neurogenesis that aids memory. However, the underlying neuronal circuitry …

Life History, Reproductive, And Demographic Parameters For Bottlenose Dolphins (Tursiops Truncatus) In Sarasota Bay, Florida, Randall S. Wells, Aleta A. Hohn, Michael D. Scott, Jay C. Sweeney, Forrest I. Townsend, Jason B. Allen, Aaron A. Barleycorn, Katherine A. Mchugh, Kim Bassos-Hull, Gretchen N. Lovewell, Deborah A. Duffield, Cynthia R. Smith, A. Blair Irvine

Biology Faculty Publications and Presentations

Studies of the resident community of bottlenose dolphins (Tursiops truncatus) of Sarasota Bay, Florida, have been conducted for more than 50 years. Detailed histories have been collected for resident individuals through integrated observations, systematic photographic identification surveys, tagging and tracking, catch-and-release health assessments, remote biopsy sampling, and stranding response. This has produced a unique dataset documenting life history milestones and vital rates of a small cetacean. Analyses of data from 482 resident Sarasota Bay dolphins have revealed estimated maximum life spans of 67 years for females and 52 years for males. For females, predicted age at sexual maturation …

Impact Of Covid-19 And Right To Healthcare: The Legal Dimensions Of Public Health Issues In India, Azim Hussain Mazumdar

Journal of Law and Public Policy

No abstract provided.

Agricultural Drought Mitigation In Carroll County, Maryland, Teresa Kaltenbacher

The Geographical Bulletin

Carroll County, with its longstanding tradition in agriculture, has had many past experiences with drought. This paper examines drought as it pertains to the farming community in the county. Precipitation statistics for the past 30 years are analyzed in context of the drought occurring in the summer of 1991. Crop loss and the subsequent implementation of federal emergency relief programs by the administering agencies within Carroll County are investigated and an assessment of their overall effectiveness is determined. Various coping strategies and perceptions of drought on an individual level are explored based on a field interview with a Carroll County …

Comentario Año A, Rodolfo Blank

Ayudas para sermones

Comentario Año A

Comentarios Nt-Iii Lucas, Rodolfo Blank

Ayudas para sermones

COMENTARIOS NT-III Lucas

Comentarios Nt-I Mateo, Rodolfo Blank

Ayudas para sermones

COMENTARIOS NT-I Mateo

The Development Of Optical Sensing Techniques As Digital Tools To Predict The Sensory Quality Of Red Meat: A Review, Georgios Anagnostou, Alessandro Ferragina, Emily C. Crofton, Jesus Maria Frias Celayeta, Ruth M. Hamill

Research Outputs: 2025-Present

No abstract provided.

Large Range Sizes Link Fast Life Histories With High Species Richness Across Wet Tropical Tree Floras, Timothy R. Baker, Stephen Adu-Bredu, Kofi Affum-Baffoe, Shin-Ichiro Aiba, Sophie Fauset, Perpetra Akite, Miguel Alexiades, Everton Almeida, Edmar Almeida De Oliveira, Esteban Alvarez Davila, Christian Amani, Ana Andrade, Luiz Aragao, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Peter Ashton, Suspense A. Averti Ifo, Gerardo A. C. Aymard, Michel Baisie, William Balee, Michael Balinga, Lindsay F. Banin, Olaf Banki, Christopher Baraloto, Jorcely Barroso, Hans Beeckman, Jean-Francois Bastin, Serge Begne, Natacha Nssi Bengone

School of Geography, Earth and Environmental Sciences

Understanding how the traits of lineages are related to diversification is key for elucidating the origin of variation in species richness. Here, we test whether traits are related to species richness among lineages of trees from all major biogeographical settings of the lowland wet tropics. We explore whether variation in mortality rate, breeding system and maximum diameter are related to species richness, either directly or via associations with range size, among 463 genera that contain wet tropical forest trees. For Amazonian genera, we also explore whether traits are related to species richness via variation among genera in mean species-level range …

Motor Pool Selectivity Of Neuromuscular Degeneration In Type I Spinal Muscular Atrophy Is Conserved Between Human And Mouse, Justin C Lee, Wendy K Chung, David J Pisapia, Christopher E Henderson

Faculty, Staff and Students Publications

Spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein. Even though SMN is ubiquitously expressed, the disease selectively affects motor neurons, leading to progressive muscle weakness. Even among motor neurons, certain motor units appear more clinically resistant to SMA. To quantitatively survey selective resistance, we studied extensive neuromuscular autopsies of Type I SMA patients and age-matched controls. We found highly divergent degrees of degeneration of neighboring motor units, even within individual cranial nerves or a single anatomical area such as the neck. Examination of a Type I SMA patient maintained on life support …

Legal Dimensions Of Rights Of Nature Applied In The Context Of The River Plym: River Plym Project Phase 1 Appendix, Jason Lowther

School of Law, Humanities and Social Sciences

This review of the literature and legal framing of so-called river rights – loosely understood by reference to the extension of certain characteristics or a particular status upon the river – has been collated in the context of the River Plym-citizenship advocacy project. It aims to examine the legal and policy potential for the attribution of ‘rights’ upon the River Plym. It does so by outlining the challenges facing the waterway, in common with many others, and noting the limitations of the current regulatory systems applied to it. The paper then offers a commentary of legal alternatives to the current …

What's New, Daniel?, Leah D. Carruth

Lorgnette: Quarterly Review of Children's and Young Adults' Books

No abstract provided.

The Iguanodon's Horn: How Artists & Scientists Put A Dinosaur Back Together Again & Again... & Again!, Pam Blake

Lorgnette: Quarterly Review of Children's and Young Adults' Books

No abstract provided.

Perla The Mighty Dog, Erica Pye

Lorgnette: Quarterly Review of Children's and Young Adults' Books

No abstract provided.

One Day This Tree Will Fall, Leah D. Carruth

Lorgnette: Quarterly Review of Children's and Young Adults' Books

No abstract provided.

News From The Chapters 1994-1995, C. Nicholas Raphael

The Geographical Bulletin

Alpha Chapter did an excellent job promoting geography this year. With 27 active members this was easy to do. We had several big projects that we took on. One was the restoration of the ISU Nature Trail which has been defunct for 10 years. The members enjoyed this outdoor project, picking up trash, old furniture and clearing the path. This project will continue to be on-going. We hope to write a selfguided tour book, create lesson plans for the local school teachers and add picnic tables and rebuild markers and signs. Our second project was to contact a local school …

2025 Sdsu Data Science Symposium Abstracts, South Dakota State University

SDSU Data Science Symposium

Abstracts for keynotes, invited sessions, and posters for the 2025 SDSU Data Symposium.

Artificial Intelligence (Ai) In Pharmacy, Giang Nguyen, Elizabeth Sartschev, John Reyes, Allie Honigford, Marisa Petrunich, Kiley Devoll, Brianna Lu, Joshua Honaker, T'Bony M. Jewell

Pharmacy and Wellness Review

Artificial Intelligence (AI) has transformed the pharmaceutical field by enabling computer software systems to learn and perform human behavior. Specifically, AI has revolutionized chronic diabetes management through continuous glucose monitoring, showcasing its immense potential in healthcare. However, alongside its transformative impact, AI’s increasing role in healthcare has prompted concerns over privacy and its premature integration. Despite these challenges, AI offers limitless opportunities to improve medication management and treatment regimens, driving advancements across various domains. From improving CT imaging to enhancing adenoma detection in colonoscopies and facilitating medication adherence, AI’s impact on healthcare is profound. Furthermore, AI plays a pivotal role …

Effect Of Vitamin K Supplementation On Insulin Resistance: A Review, Samantha Mccord, Rebecca Willier, Kaitlyn Kirby, Kaylin Mahoney, Lance Dillon, Rileigh Rahrig, Brianna Lu, Joshua Honaker, Emily Eddy

Pharmacy and Wellness Review

Insulin resistance is one of the pathological hallmarks that leads to the development of type II diabetes mellitus (T2DM). Around 40% of people aged 18 to 44 living in the United States have insulin resistance. Recent research, coupled with a better understanding of how vitamin K functions in the body, suggests that this vitamin could potentially help reduce insulin resistance. Vitamin K is not included in the American Diabetes Association (ADA) guidelines for the treatment of insulin resistance, but it has been shown to have some benefits in patients with T2DM. It may also serve as a treatment option for …

The Melanesian Triad Of Unity, Ibrahim Peyon

Antropologi Indonesia

In the Melanesian worldview, humans, land, waters, plants, animals and the entire universe were created by the Creator God, and this is the essence of the original religions in Melanesia. This paper investigates this basic Melanesian philosophy, which is called the Melanesian Triad of Unity here. Oneness denotes God the Creator as the core entity, the parts of his body constituting all beings and the universe. The three principles are 1) one nation, 2) one soul and one spirit, and 3) one land and nature. All the elements are composed naturally in these three principles. As argued in this paper, …

Epr Imaging Workshop: From Theory And Practice To Applications, Arthur H. Heiss, Ralph T. Weber, Sandra S. Eaton, Gareth R. Eaton

TeachEPR Submissions

Methods of imaging and insights from imaging are described. Practical aspects of sample type and dimensions are described.

Workshop presented at the 27th International EPR Symposium, sponsored by Bruker BioSpin EPR Division and the University of Denver, in Denver, Colorado on August 1, 2004.

The Beacon, February 7, 2025, Beacon Staff

The Beacon, 2024-2025

Unsung Hero: Dr. Doug Anderson; County coffee shop showdown; Flipturn's album highlights vocal range; "Mufasa" deemed a crime against the original; Senior spotlight: double major Elliana Zerr; Dr. Bates leads youth program launch in Kenya; Beacon staff highlights and changes; Local brews and fresh reviews; Practical benefits of studying abroad; Archives hero at NW; The greatest romance story; Living a monastic life; The big game: Predictions from NW staff; Softball off to a great start to 2025 season; Students enjoy winter intramurals at NW; DeepSeek: a new AI competitor; Orange City to host RAGBRAI;

Scènes À Faire: Archetype, Innovation, And The Philosophy Of Trust, Marc Levan

Journal of Business & Technology Law

No abstract provided.

The Feasibility Of Flipbook-Based Wawasan Nusantara Teaching Materials In Citizenship Learning, Sri Yunita, Sugiharto Sugiharto, Sri Hadiningrum, Julia Ivanna, Alif Firdaus

Jurnal Civics: Media Kajian Kewarganegaraan

Learning media has a significant influence on learning outcomes. Using appropriate media can increase motivation, understanding, retention, practical skills, accessibility and collaboration in learning. However, the effectiveness of media also depends on design, implementation and learning context. Therefore, educators need to choose and design media that suits the goals and needs of students. This research aims to (1) produce flipbook-based Wawasan Nusantara teaching material products and (2) Understand the feasibility of flipbook-based Wawasan Nusantara teaching materials. The development model used in this research is ADDIE. The needs analysis results of lecturers and students show that the need for flipbook-based Indonesian …

The Student Movement Volume 109 Issue 13: Building Purpose During Week Of Prayer, Ayanda Dewa, Esther Martin, Andrew Francis, Audrey Lim, Melanie Webb, Nate Miller, Natalie Mendonça, Lia Glass, Amelia Stefanescu, Katherine Pierre, Anna Rybachek

The Student Movement V. 109 (2024-2025)

HUMANS

Are We There Yet? Michigan's Long-winded Winter, Ayanda Dewa

Ysa Dennis on Caribbean Club Goals and Events, Esther Martin

Andrews Black History: World Changing from Motown to Broadway, Andrew Francis

ARTS & ENTERTAINMENT

The Brutalist and AI in Hollywood (Part One), Audrey Lim

The King's Singers at HPAC, Melanie Webb

When I Call an Orange Good, Nate Miller

NEWS

Beyond the Headlines: The Overlooked Reality of a Community's Recovery, Natalie Mendonça

New President, New Changes, Lia Glass

Andrews University Week of Prayer Fosters Faith and Community, Amelia Stefanescu

IDEAS

DEI Initiatives: Where Do We Go From Here?, Katherine Pierre …

The Scarlet - Volume Ciii, No. 8 (February 7, 2025), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The February 7, 2025 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

2025-02-07 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of February 7, 2025, which includes the meeting minutes of the meeting held on November 15, 2024.