Digital Commons Network^™

Evaluation Of Anti-Epileptic Activity Of Lantana Camara (Linn.) Flowers In Swiss Albino Mice, Kundan Singh Bora, Baldev Singh

The Thai Journal of Pharmaceutical Sciences

Introduction: Globally, approximately 50 million people are being affected by epilepsy and nearly 80% occurring in the developing countries. The plant Lantana camara Linn. (Family: Lamiaceae) is native to the tropical regions of the America, Africa, and Asia. It is found in Kumaon and Garhwal region of Uttarakhand, India. The plant has been used for various ailments in traditional systems of medicines for the treatment of epilepsy, wounds, tumor, stomach ache, and inflammation. Objective: The present study was planned with an objective to evaluate antiepileptic activity of L. camara flowers in mice. Methods: Maximum electric shock (MES) and pentylenetetrazoleinduced (PTZ) …

Parental Strategies For Modifying Behavior: The Positives Of Positive Reinforcement, Benjamin D. Rasmussen

Intuition: The BYU Undergraduate Journal of Psychology

This research investigates the effectiveness of positive reinforcement as a central parenting strategy for modifying children’s behavior, grounded in B.F. Skinner’s operant conditioning theory. Using factor analysis, two key factors emerged: the impact of positive reinforcement on behavior change and its influence on parent-child dynamics. Positive reinforcement, which involves rewarding desirable behaviors with positive stimuli, has been found to promote the repetition of those behaviors and yield beneficial long-term outcomes. The evidence indicates that this approach not only strengthens desirable behaviors but also enhances the quality of relationships between parents and children, and teachers and students. Although some argue that …

A Language Narrative, Jer Xiong

Journal of Southeast Asian American Education and Advancement

"A Language Narrative" is about the author's own journey with the English language, fanfiction, online spaces, and the decision to be a writer.

Literary Orphan, Jer Xiong

Journal of Southeast Asian American Education and Advancement

"Literary Orphan" is a flash creative nonfiction.

Ideological Influences On Skills And Knowledge In Nonprofit Leadership, Faiza Venzant, Julianne Gassman

Journal of Ideology

Understanding the skills and knowledge required for effective nonprofit leadership can be challenging. This position paper suggests that skills and knowledge come from both formal training programs at colleges, universities, professional associations, and consultant presentations but is also based on the personal lived experiences of leaders. While Ideology such as neoliberalism intentionally or unintentionally influence both formal training and lived experiences, common good ideology, an ideology that grounds the idea that nonprofits exist for the betterment of society, should guide leaders of the nonprofit sector and be an important consideration. Embracing common good ideology better centers equity appropriately for the …

The Safety Of Ramadan Fasting In Chronic Heart Failure Patients With Reduced Ejection Fraction, Ahmed Farouk Alaarag, Mahmoud Abd Elkhalek Abou-Omar, Osama Ahmed Amin

Journal of the Saudi Heart Association

Objectives: Even though Islam excludes the sick from Ramadan Fasting (RF), countless Muslims choose to fast throughout this holy month. So, it is of paramount importance to review how RF influences patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF). Our study intended to check the safety of RF in these patients.

Methods: We selected patients under 75 years old with compensated chronic HFrEF. After applying all the exclusion conditions, those who insisted on fasting during the coming Ramadan were enrolled in fasting Group I (90 patients). Those who decided not to fast were listed as control Group …

Commonwealth Times 2025-02-12

Commonwealth Times, 1969-

No abstract provided.

The Impact Of War On Innocence, Khanh Luong

CAFE Symposium 2025

Grave of the Fireflies, directed by Isao Takahata, focuses on the impact of war on innocent civilians, specifically children, rather than on battles or acts of heroism. The film establishes a tone of powerlessness from the start. This poster examines the symbolism of fireflies in the movie and the destruction of innocence throughout the movie. The film reflects the childhood trauma of both the movie's writer and the director.

The Valley Of The Wind And Buddhism, Grace Aulicino

CAFE Symposium 2025

Hayao Miyazaki’s Nausicaä of the Valley of the Wind is a philosophical exploration of fulfillment, rooted in Buddhist and Taoist principles. The film contrasts the destructive forces of greed and individualism, embodied by Kushana and the Tolmekians, with the harmonious collectivism of the People of the Valley of the Wind. Nausicaä, the film’s heroine, challenges traditional gender norms by being a strong, selfless leader who seeks peace and balance rather than power. Her journey reflects the Taoist ideal of surrender as a path to enlightenment, ultimately sacrificing herself to unite humanity and nature. Through stunning visuals and rich storytelling, Miyazaki …

Ethical Problems Of Enforcing Justice In Death Note And Psycho-Pass Anime, Aldiyar Alen

CAFE Symposium 2025

What happens when justice is controlled by a single person or a powerful system? This research explores how Death Note and Psycho-Pass show the dangers of extreme justice. In Death Note, Light Yagami takes the law into his own hands, believing he can create a perfect world by eliminating criminals. In Psycho-Pass, an advanced AI system judges people before they even commit crimes, deciding their fate based on predictions. Both systems aim to reduce crime but end up threatening personal freedom and fairness. By comparing these stories, this study highlights the risks of justice without balance, questioning how …

Pom Poko: When Nature Speaks Out Against Urbanization, Sabrina Huynh

CAFE Symposium 2025

Pom Poko highlights the correlation between the survival of nature and the progress of humanity. Therefore, by showing different dynamic relationships like Gonta’s aggressive way of fighting against or peaceful co-existence of Shoukichi, Pom Poko suggests viewers may feel that humans should find a way to live harmoniously with the environment.

Isekai: Discovering Factors That Contributed To Its Success And Diving Into The Mentality Of Contemporary Japanese Citizens, Anh Duc Nguyen

CAFE Symposium 2025

Isekai, an anime and manga genre where characters are transported to another world, has become popular in recent years. This paper examines the factors contributing to this phenomenon, exploring how isekai works resonate with contemporary Japanese citizens. It argues that the genre's appeal lies in its ability to offer escapism from societal pressures, particularly those stemming from economic hardship and a lack of perceived agency. By analyzing important and known isekai works, including Tensei shitara Slime Datta Ken, this paper demonstrates how the genre fulfills a desire of the Japanese for fulfillment and sense of agency. Furthermore, it explores …

The Mir-290 And Mir-302 Clusters Are Essential For Reprogramming Of Fibroblasts To Induced Pluripotent Stem Cells, Julia Ye, Ryan M Boileau, Ronald J Parchem, Robert L Judson-Torres, Robert Blelloch

Faculty, Staff and Students Publications

The miR-290 and miR-302 clusters of microRNAs are highly expressed in naïve and primed pluripotent stem cells, respectively. Ectopic expression of the embryonic stem cell (ESC)-specific cell cycle regulating family of microRNAs arising from these two clusters dramatically enhances the reprogramming of both mouse and human somatic cells to induced pluripotency. Here, we used genetic knockouts to dissect the requirement for the miR-290 and miR-302 clusters during the reprogramming of mouse fibroblasts into induced pluripotent stem cells (iPSCs) with retrovirally introduced Oct4, Sox2, and Klf4. Knockout of either cluster alone did not negatively impact the efficiency of reprogramming. Resulting cells …

Common Threads In Monsters Across Time And Space, Jade Gladue

CAFE Symposium 2025

Fear is an undeniable human emotion, and monsters have always been a way for human societies to grapple with and explain our fears. In this project, common aspects and groupings of monsters across different indigenous cultures and folklores are discussed and dissected to determine inherent human reactions to fear. The project identifies and analyzes types of monsters and what the hidden meaning behind the existence and endurance of these creatures might be.

How To Conduct Serious Affairs Like Reasonable People, Yakov Malkiel

St. Mary's Law Journal

No abstract provided.

The Bg News February 12, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 12, 2025. Volume 104-Issue 17.

The Core Circadian Clock Factor, Bmal1, Transduces Sex-Specific Differences In Both Rhythmic And Nonrhythmic Gene Expression In The Mouse Heart, Xiping Zhang, Spencer B. Procopio, Haocheng Ding, Maya G. Semel, Elizabeth A. Schroder, Mark R. Viggars, Tanya S. Seward, Ping Du, Kevin Wu, Sidney R. Johnson, Abhilash Prabhat, David J. Schneider, Isabel G. Stumpf, Ezekiel R. Rozmus, Zhiguang Huo, Brian P. Delisle, Karyn A. Esser

Physiology Faculty Publications

No abstract provided.

Phgdh Inhibition And Foxo3 Modulation Drives Puma-Dependent Apoptosis In Osteosarcoma, Toshinao Oyama, Caitlyn B Brashears, Richa Rathore, Heather Benect-Hamilton, Katharine E Caldwell, Naomi Dirckx, William G Hawkins, Brian A Van Tine

2020-Current year OA Pubs

Osteosarcoma is a bone cancer that has been found to be metabolically dependent on the conversion of glucose to serine through the rate-limiting enzyme 3-phosphoglycerate dehydrogenase (PHGDH). The upregulation of PHGDH has been correlated with poor patient survival, and the inhibition of the serine synthesis pathway using targeted small-molecule inhibition of PHGDH induces a rapid metabolic adaptation that prevents cell death due to pro-survival signaling through the mammalian target of rapamycin complex 1 (mTORC1) pathway. Here, PHGDH inhibition in combination with mTORC1 signaling modulation for the treatment of osteosarcoma was evaluated. When combined with PHGDH inhibition, several non-rapalog inhibitors of …

Jamaican Tertiary Education Lecturers’ Perceptions Of Repurposing Paper Instructional Materials For Blended Learning, Bobsie Sophia Levy

Walden Dissertations and Doctoral Studies

Transitioning from paper-based instructional methods to blended learning has rapidly been implemented across higher education institutions in Jamaica. The problem that was addressed through this study was that little is known about the perceptions of Jamaican lecturers regarding their experiences towards repurposing instructional materials for blended learning. The purpose of this qualitative study was to explore the perceptions of Jamaican tertiary education lecturers regarding the experience of repurposing paper instructional materials into digital form for blended learning. The framework for the study was Davis’s technology acceptance model. For this basic qualitative study, seven semistructured interviews were conducted, and a thematic …

Fiber- And Acetate-Mediated Modulation Of Mhc-Ii Expression On Intestinal Epithelium Protects From Clostridioides Difficile Infection, José L Fachi, Tihana Trsan, Silvia Penati, Susan Gilfillan, Siyan Cao, Krzysztof L Hyrc, Xiuli Liu, Patrick Fernandes Rodrigues, Bishan Bhattarai, Marco Colonna, Et Al.

2020-Current year OA Pubs

Here, we explore the relationship between dietary fibers, colonic epithelium major histocompatibility complex class II (MHC-II) expression, and immune cell interactions in regulating susceptibility to Clostridioides difficile infection (CDI). We find that a low-fiber diet increases MHC-II expression in the colonic epithelium, which, in turn, worsens CDI by promoting the development of pathogenic CD4

Exploring Experience Of Autism Among School Staff And Parents Of Autistic Children, And The Relevance Of Totalising And Non-Totalising Approaches To Facilitate Understandings., Emin Cetinbas

School of Law, Humanities and Social Sciences Theses

This thesis explored how the parents and school staff (teachers and teaching assistants) of primary aged autistic children understand and experience autism, including observation of the children they care for and educate. Totalising was used as a framework for conceptualising their understanding and use of non-totalising approaches such as externalising was also explored. Specific questions centred on a) how parents and teaching staff understand and experience autism in terms of the child being similar or different to other children, b) how relevant totalising is as a concept to aid in understanding of how the parents and teaching staff view autistic …

An Improved Process For The Preparation Of Polysaccharide, Anonymous

Defensive Publications Series

The present disclosure relates to an improved process for preparing polysaccharide.

Book Review: After Sex, Anya Metzer

Journal of International Women's Studies

No abstract provided.

The Ethical Quandaries Of Commercialized Surrogacy In India And Its Representation In Bollywood Films, Shruti Das, Deepshikha Routray

Journal of International Women's Studies

Assisted Reproductive Technology (ART) has been seen as a blessing for couples and individuals who desire to have children and who do not want to adopt. A common technique of ART is surrogacy—the process by which a woman agrees to carry and give birth to another individual’s or couple’s child, often as an act of philanthropy. Because of the costly medical expenses for this process in high-income countries, many clients have sought surrogates in lower-income countries, such as Nepal, Thailand, and India, to lessen the cost. This has contributed to what is known as “surrogacy consumerism,” in which women are …

Motherhood, Infertility, And Femininity In Fadia Faqir’S Pillars Of Salt, Fozia Sheikh, Munejah Khan

Journal of International Women's Studies

In the patriarchal tradition of the Arab world, women are often treated as commodities, and their autonomy and choices are disregarded. Family honour is tied to women’s virginity, leading to strict control over their desires and sexuality (Khan 3). Moreover, women are confined to roles as biological and cultural procreators, reinforcing a narrow understanding of femininity (Chouiten and Khireddine 40) and tightly weaving womanhood with motherhood. This essay examines Fadia Faqir’s novel Pillars of Salt (1996) by using a feminist framework, particularly Adrienne Rich’s theory of motherhood. The narrative reveals the brutal realities faced by Arab women, particularly those incapable …

Clinical Effectiveness Of Biodentine In Adult Pulpotomy Procedures: A Systematic Review, Aditya Deshpande, Shilpa Bhandi, Shankargouda Patil, Frank W. Licari

Annual Research Symposium

This systematic review aimed to evaluate the evidence from randomised clinical trials for the effectiveness of pulpotomy using Biodentine in adult humans, focusing on clinical outcomes of pain after the procedure and radiographic evaluations.

Intensive Lifestyle Intervention, Cardiac Biomarkers, And Cardiovascular Outcomes In Diabetes: Look Ahead Cardiac Biomarker Ancillary Study, Kershaw V Patel, Zainali Chunawala, Subodh Verma, Matthew W Segar, Katelyn R Garcia, Chiadi E Ndumele, Thomas J Wang, James L Januzzi, Antoni Bayes-Genis, Javed Butler, Carolyn S P Lam, Christie M Ballantyne, James A De Lemos, Alain G Bertoni, Mark Espeland, Ambarish Pandey

Faculty, Staff and Students Publications

Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) are associated with cardiovascular outcomes and are recommended for measurement in type 2 diabetes (T2D). However, the effects of an intensive lifestyle intervention (ILI) targeting weight loss on cardiac biomarkers and the prognostic association of changes in these biomarkers with risk of adverse cardiovascular outcomes in T2D are not well-established.

Objectives: This study sought to evaluate the effects of an ILI on cardiac biomarkers and the association of changes in cardiac biomarkers with risk of cardiovascular outcomes in T2D.

Methods: Participants of the Look AHEAD (Action for Health …

Mbnl Overexpression Rescues Cardiac Phenotypes In A Myotonic Dystrophy Type 1 Heart Mouse Model, Rong-Chi Hu, Yi Zhang, Larissa Nitschke, Sara J Johnson, Ayrea E Hurley, William R Lagor, Zheng Xia, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a CTG repeat expansion in the dystrophia myotonica protein kinase (DMPK) gene. The expanded CUG repeat RNA (CUGexp RNA) transcribed from the mutant allele sequesters the muscleblind-like (MBNL) family of RNA-binding proteins, causing their loss of function and disrupting regulated pre-mRNA processing. We used a DM1 heart mouse model that inducibly expresses CUGexp RNA to test the contribution of MBNL loss to DM1 cardiac abnormalities and explored MBNL restoration as a potential therapy. AAV9-mediated overexpression of MBNL1 and/or MBNL2 significantly rescued DM1 cardiac phenotypes including conduction delays, contractile …

Chemical Composition And Larvicidal Toxicity Of Ricinus Communis L. (Euphorbiaceae) Extracts Against Larvae Of Thaumetopoea Pityocampa (Denis & Schiffermüller, 1775) (Lepidoptera: Notodontidae), Memi̇ş Kesdek, Şaban Kordali, Selçuk Küçükaydin

Turkish Journal of Agriculture and Forestry

In this study, the toxicities of extracts obtained from the seeds and leaves of castor bean (Ricinus communis L.) (Euphorbiaceae) plant against five larval stages of the pine processionary moth (PPM) (Thaumetopoea pityocampa (Denis & Schiffermüller, 1775) (Lepidoptera: Notodontidae)) were investigated under laboratory conditions. Petroleum ether, acetone, and methanol extracts were prepared at various concentrations (0.25, 0.5, and 1 mg/mL) and sprayed on each larval stage. Each test was performed with three replications and two repetitions. Sterile water + ethanol was used as a negative control and the commercial chemical Kormilin 25 WP (25% diflubenzuron) was used as a positive …

Phytochemical Analysis And In Vitro And In Vivo Pharmacological Activities Of Cordia Myxa Extracts, Tatheer Fatima, Mirza Imran Shahzad, Adnan Noor Shah, Zhang Yi, Bushra Gillani, Iqra Hussain, Adina Gillani, Zeli̇ha Çi̇ftçi̇, Marcello Locatelli, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary

Turkish Journal of Agriculture and Forestry

Cordia myxa is found in tropical regions of Pakistan, where it is commonly known as lasura. This study aimed to assess the preliminary results of phytochemical analysis and the pharmacological activities of C. myxa. After pulverizing the fresh plant, extracts were prepared using different solvents, including aqueous, methanol, ethanol, dichloromethane, ethyl acetate, and n-hexane extracts. These extracts were examined for total phenolic contents using standard biochemical tests and high performance liquid chromatography with a photodiode array. In further evaluations, antioxidant, antibacterial, antiviral, hen’s egg test on chorioallantoic membrane (HETCAM) assay, antipyretic, antiinflammatory, and antidiabetic activities were monitored. Using ferric reducing …