Digital Commons Network^™

An In Vivo Screen Identifies Nat10 As A Master Regulator Of Brain Metastasis, Jocelyn F Chen, Peng Xu, Wesley L Cai, Huacui Chen, Emily Wingrove, Xiaojian Shi, Wenxue Li, Giulia Biancon, Meiling Zhang, Amer Balabaki, Ethan D Krop, Elianna Asare, Yangyi Zhang, Mingzhu Yin, Toma Tebaldi, Jordan L Meier, Thomas F Westbrook, Stephanie Halene, Yansheng Liu, Hongying Shen, Don X Nguyen, Qin Yan

Faculty, Staff and Students Publications

Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis, the major cause of cancer-related deaths. Here, we conducted an in vivo screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) as a driver of brain metastasis. Knockdown of NAT10 restrains cancer cell proliferation and migration in vitro and tumor growth and brain metastasis in vivo. The poorly characterized RNA helicase domain of NAT10 is critical for cell growth in vitro, while both RNA helicase and NAT domains are essential for primary tumor growth and brain metastasis in vivo. Mechanically, NAT10 promotes the …

The Emergence Of Human Primordial Germ Cell-Like Cells In Stem Cell-Derived Gastruloids, Jitesh Neupane, Gabriele Lubatti, Theresa Gross-Thebing, Mayra Luisa Ruiz Tejada Segura, Richard Butler, Sargon Gross-Thebing, Sabine Dietmann, Antonio Scialdone, M Azim Surani

2020-Current year OA Pubs

Most advances in early human postimplantation development depend on animal studies and stem cell-based embryo models. Here, we present self-organized three-dimensional human gastruloids (hGs) derived from embryonic stem cells. The transcriptome profile of day 3 hGs aligned with Carnegie stage 7 human gastrula, with cell types and differentiation trajectories consistent with human gastrulation. Notably, we observed the emergence of nascent primordial germ cell-like cells (PGCLCs), but without exogenous bone morphogenetic protein (BMP) signaling, which is essential for the PGCLC fate. A mutation in the

Patient Selection, Ventricular Tachycardia Substrate Delineation, And Data Transfer For Stereotactic Arrhythmia Radioablation: A Clinical Consensus Statement Of The European Heart Rhythm Association Of The European Society Of Cardiology And The Heart Rhythm Society, Katja Zeppenfeld, Clifford Robinson, Et Al.

2020-Current year OA Pubs

Stereotactic arrhythmia radioablation (STAR) is a novel, non-invasive, and promising treatment option for ventricular arrhythmias (VAs). It has been applied in highly selected patients mainly as bailout procedure, when (multiple) catheter ablations, together with anti-arrhythmic drugs, were unable to control the VAs. Despite the increasing clinical use, there is still limited knowledge of the acute and long-term response of normal and diseased myocardium to STAR. Acute toxicity appeared to be reasonably low, but potential late adverse effects may be underreported. Among published studies, the provided methodological information is often limited, and patient selection, target volume definition, methods for determination and …

Studies On Cell Cycle Regulation And Ecm Modification During Tubular Organ Formation In Drosophila Embryos, Jeffrey Matthew

LSU Doctoral Dissertations

The formation of tubular organs—such as the heart and kidneys—is a complex developmental process that requires the precise coordination of tissue remodeling with dynamic changes in cellular behavior. Key processes including cell proliferation, apoptosis, and extracellular matrix (ECM) formation must be tightly synchronized with mechanisms that generate and transmit physical forces, transforming a flat epithelial sheet into a three-dimensional organ. Disruptions in the homeostasis of these processes during organogenesis can lead to congenital defects, such as pulmonary atresia and renal hypoplasia.

To investigate the mechanisms underlying epithelial morphogenesis, the Chung laboratory employs the Drosophila embryonic salivary gland (SG) as a …

Voices Of Heritage And Resilience: A Performance Guide To Soprano Arias Celebrating The Black Experience In Opera, Imani S. Francis

LSU Doctoral Dissertations

Voices of Heritage and Resilience: A Performance Guide for Soprano Arias Celebrating the Black Experience explores a selection of soprano arias that illuminate the depth, complexity, and resilience of Black identity through opera. This study provides historical context, musical style, and vocal performance strategies for works that center around the African American experience, spanning both traditional and contemporary repertoire.

By examining the relations between text, music, and historical significance, this dissertation highlights how these arias convey themes of struggle, conflict, oppression, love, and perseverance. It also supplies guidance to the singer through the use of vocal methods, interpretation, and stylistic …

Characterization Of Hepatic Pathology During Azoxymethane-Induced Acute Liver Failure, Shadikchhya Maya Bhattarai, Ashwin Jhawer, Gabriel Frampton, Eleonora Troyanovskaya, Sharon Demorrow, Matthew Mcmillin

Faculty, Staff and Students Publications

Background: Acute liver failure (ALF) is a loss of liver function due to a severe hepatic insult. Studies utilizing the azoxymethane (AOM) mouse model of ALF, which also generates hepatic encephalopathy, have primarily focused on development of neurological deficits. However, the molecular processes that generate liver damage have not been fully characterized. Therefore, a more comprehensive characterization of the hepatic consequences of AOM toxicity is needed to better understand this disease model.

Aim: To identify molecular pathology contributing to hepatic injury during the progression of AOM-induced ALF.

Methods: C57BL/6 mice were injected with AOM to produce ALF and hepatic encephalopathy. …

Data Collection And Field Research Opportunities And Problems In India, A. K. Chakravarti

The Geographical Bulletin

There are few countries in the world which can provide such a wide range of problems for field study as India. For both macro and micro level studies, spatial variations in physical, cultural, economic and political conditions within a short distance may be phenomenal and provide a complex matrix for analysis. India is divided into linguistic states. A linguistic state in turn may contain tertiary subcultures, each with a different set of conditions within its boundaries. On a linguistic state may be superimposed three distinct areas of tertiary subcultures, viz., urban, rural-and tribal, each with different levels of education, standard …

Astronomical Geography: An Examination Of The Early American Literature, James W. Vining

The Geographical Bulletin

Judging from textbooks in geography, there must be educational value in starting with the general and proceeding to the specific, an application of the deductive approach. It is not uncommon today for introductory physical geography and earth science textbooks to precede the examination of the planet's interior, land-water surface, and atmosphere with a brief survey of the fundamentals of astronomy. Not only is this true today, it has been true from the beginnings of American geography, as this study documents. Specifically, this paper examines the information on astronomy in geography school books published before 1850 for the purposes of determining …

The Shorthorn: May 16, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: May 02, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: April 18, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: March 21, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: March 14, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: February 28, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: February 14, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: February 21, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: December 20, 1932

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: October 18, 1932

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

Monitoring Population Pressure In The Semiarid Zone Of Kenya, Isaac Sindiga

The Geographical Bulletin

Population pressure is a maladjustment between resources of a community and its population. This maladjustment worsens when the population increases at a faster rate than the development of the economy. The pressure leads to the deterioration of land resources and low, risky income opportunities and widespread poverty. Kenya's population growth rate of 4 percent per year is one of the highest in the world. Its populationresource relations are deteriorating and foreshadow the country's future. In the semi-arid and arid parts of the country, especially those occupied by traditional pastoral people, population pressures are particularly serious. Here, the pressures of people …

A History Of Urban Development In The U.S.S.R., Ernest T. Hendrix

The Geographical Bulletin

It need hardly be emphasized that a nation the size of the Soviet Union consolidation under a central government was not a simple task, but the culmination of an ongoing historical process. In order to consider the present stage of development, it should be viewed in its historical context. This will aid in understanding the reasons for the communist revolution and the central planning scheme which resulted. EARLY RUSSIAN HISTORY Early Russian history began in approximately 400 AD. when eastern Slavonic tribes (Russians) called Antae migrated to what became Russian territory from the vicinity of the Prepit marshes and neighboring …

Guiding Principles And Use Of Government Subsidies In The Development Of The High Mountain Regions Of Switzerland And Bavaria, Elsa T. Schmidt

The Geographical Bulletin

The major contention of this paper is that the development incentive programs of German and Swiss national governments are justified if they bring about an increase in productivity and national income. However, they must also preserve the ecological environment, cultural landscape, and nature areas of the Alpine setting. A comparative study of regional development policies of Switzerland and the German State of Bavaria is used to determine how each national government allocates its regional development subsidies and the results they hope to obtain.

Volume 26 Complete Issue, Robert M. Ward

The Geographical Bulletin

Volume 26 Complete Issue

The Syrian Tabqa Dam: Its Development And Impact, Monib Ei-Khatib

The Geographical Bulletin

The Euphrates River has its sources in eastern Turkey's Anatolian Plateau and extends 3,000 kilometers through Syria and Iraq before it discharges into the river's delta at Shat AI-Arab in the Arabian Gulf. It is an exotic river, a center of past civilization and population, and a managed river with an extensive delta. It floods in early summer but its flooded area dries-out very quickly in the semiarid climate. The Euphrates River can maintain an annual flow throughout its course because of relatively high rainfall and snow-melt at higher elevations. Utilization of its drainage basin has been intensified from its …

Volume 27 Complete Issue, Robert M. Ward

The Geographical Bulletin

Volume 27 Complete Issue

The Nowruz Oil Spill In The Arabian Gulf: Case Study Of Saudi Arabia, Abdullah S. Ai-Amirah

The Geographical Bulletin

The Arabian Gulf has suffered from hundreds of oil spills, some of them reported but most unreported. In many cases the amounts of the spills and their causes are usually undetermined. During 1978-1979, tanker captains reported to the Japan Oceanographic Data Center about 412 oil slicks in the Gulf and its approaches.' Table 1 shows major oil spills exceeding 3,000 barrels which occurred between August, 1980, and August, 1982. Although these are relatively current, it should be noted that other significant oil spills have occurred since oil was discovered in the region by Iran in 1908.

Web Application For Simulation Of An Agent-Based Model In Netlogo3d, Chris Davis Perumal, Abraham Nofal, Benedict J. Kolber, Rachael Miller Neilan

Spora: A Journal of Biomathematics

Agent-based models (ABMs) are computer simulation models for studying systems of autonomous agents. Modelers often use specialized software like NetLogo to develop ABMs, but this software poses barriers to researchers in other disciplines with no prior programming experience. To address this issue, we developed a web application that allows users to simulate our ABM via a web browser, eliminating the need for the user to download and use specialized software. While presented in the context of a specific ABM, our approach can be applied to other ABMs to enhance accessibility. The ABM presented here was developed in NetLogo3D. The model …

The Shorthorn: April 19, 1932

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: April 05, 1932

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: March 22, 1932

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: March 08, 1932

The Shorthorn Newspaper Collection: 1930s

No abstract provided.