Digital Commons Network^™

The Rise, Fall, And Resurgence Of Phage Therapy For Urinary Tract Infection, Jacob J Zulk, Kathryn A Patras, Anthony W Maresso

Faculty, Staff and Students Publications

In the face of rising antimicrobial resistance, bacteriophage therapy, also known as phage therapy, is seeing a resurgence as a potential treatment for bacterial infections including urinary tract infection (UTI). Primarily caused by uropathogenic Escherichia coli, the 400 million UTI cases annually are major global healthcare burdens and a primary cause of antibiotic prescriptions in the outpatient setting. Phage therapy has several potential advantages over antibiotics including the ability to disrupt bacterial biofilms and synergize with antimicrobial treatments with minimal side effects or impacts on the microbiota. Phage therapy for UTI treatment has shown generally favorable results in recent …

December 2024 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council

Graduate Council Minutes

No abstract provided.

Delta Connections Garner Award For Ole Miss Author, Rebecca Lauck Cleary

University of Mississippi News

OXFORD, Miss. – Writing has been a lifelong pursuit for Ralph Eubanks, one that has led him through the publishing world, academia and the Library of Congress. The University of Mississippi alumnus recently received two honors that reflect this success in practicing and supporting the craft of writing.

Custom Cathode Optimization For Electropolishing Additively Manufactured 316l Stainless Steel, Kasandra Escarcega Herrera

Mechanical Engineering ETDs

Laser powder bed fusion (LPBF) has become increasingly popular for its ability to rapidly manufacture complex metallic parts. However, the surface properties of as-built LPBF parts may degrade overall performance due to tortuous surface features. Consequently, post-processing like electropolishing (EP) to reduce the surface asperities is often needed for LPBF parts to perform as expected. Utilizing experimental and computational approaches, this project aims to more uniformly EP complex shaped parts made from LPBF 316L. For the experimental approach, parts with a three-dimensional T-shape were printed out of 316L stainless steel and EP using an acidic-based and a polyethylene glycol/NaCl-based electrolyte. …

Women, Collective Creative Practice, And Community Health, Anne Hensley

Honors Theses

A growing body of research shows that art therapy yields positive outcomes for those experiencing stress and mood disorders. Creative arts therapies have been shown to lower cortisol, improve personal and universal outlook, decrease symptoms of anxiety and depression, increase self-esteem and confidence, alleviate burnout, help individuals to cope with trauma, and support brain function through activity-dependent plasticity. However, little research has been done on collective and collaborative arts, and the enhanced benefits communal practice might bring. Additionally, art therapy is inaccessible to many, due to a dearth of practitioners and cultural and socioeconomic barriers to participation. Peri-, menopausal, and …

Gonadal Absence Of Pig-1: Exploration Of Pig-1 In The Gonad Of Caenorhabditis Elegans, Winston S. Bennah

Undergraduate Theses

Caenorhabditis elegans are model organisms frequently studied to better understand biological processes. They have short life spans and produce a large number of progeny. Additionally, many of their molecular development processes can be found in human, providing insight into cell death and cell fate. In this project, our research aims to create a triple mutant strain to test the importance of the pig-1 gene in the gonad of C. elegans. This strain carries the following alleles: ckb-3::degron; him-8; gfp::pig-1. The pig-1 gene has been previously studied in neuroblast cells in C. elegans and is required for …

Elevated Ambient Temperature Associated With Reduced Infectious Disease Test Positivity Rates: Retrospective Observational Analysis Of Statewide Covid-19 Testing And Weather Across California Counties., Nicholas Wing-Ping Kwok, Joshua Pevnick, Keith Feldman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: From medication usage to the time of day, a number of external factors are known to alter human body temperature (BT), even in the absence of underlying pathology. In select cases, clinical guidance already suggests the consideration of clinical and demographic factors when interpreting BT, such as a decreased threshold for fever as age increases. Recent work has indicated factors impacting BT extend to environmental conditions including ambient temperature. However, the effect sizes of these relationships are often small, and it remains unclear if such relationships result in a meaningful impact on real-world health care practices.

OBJECTIVE: Temperature remains …

Small Molecule With Big Impact: Metarrestin Targets The Perinucleolar Compartment In Cancer Metastasis, Vivek Kashyap, Bhuvnesh Sharma, Divya Pandey, Ajay K. Singh, Godwin Peasah-Darkwah, Bhupesh Singh, Kuldeep K. Roy, Murali Yallapu, Subhash Chauhan

School of Medicine Publications

Metarrestin (ML246) is a first-in-class pyrrole-pyrimidine-derived small molecule that selectively targets the perinucleolar compartment (PNC). PNC is a distinct subnuclear structure predominantly found in solid tumor cells. The occurrence of PNC demonstrates a positive correlation with malignancy, serving as an indicator of tumor aggressiveness, progression, and metastasis. Various promising preclinical results have led to the clinical translation of metarrestin into a first-in-human trial. This review aims to summarize (i) the current understanding of the structure and function of PNC and its role in cancer progression and metastasis, (ii) key findings from studies examining the effect of metarrestin on various cancers …

Why Law "Beyond The State" Need Not Be A Threat To Democratic Values, Paul Schiff Berman

Buffalo Law Review

Discussions of “law beyond the state” almost inevitably run into objections from those who believe that sub- or supranational legal orders necessarily subvert local democratic governance. Self-proclaimed populists and others express concern that the “will of the people” will be unduly subjected to the dictates of “cosmopolitan elites”1 or local factions, or corporate capture. These objections range across the political spectrum. Those on the right tend to focus on concerns that transnational orders will impose human rights or immigration rules on a national polity, while those on the left worry about trade regimes that might impose local labor or environmental …

Review Of Human Anatomy: Self-Assessment Review Questions, Jorge L. Canchola

Open Educational Resources - Reviews

No abstract provided.

Wmu Board Of Trustees Formal Session December 12, 2024, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Acceptance of the Agenda

Approval of the Minutes (September 26, 2024 and October 16, 2024 Meetings)

Remarks by the Chair of the Board

Remarks by the President

Updates by the Faculty Senate President

Updates by the Western Student Association President

Updates by the Graduate Student Association President

Presentation: Advancing EV Technology through Education

Public Comments Regarding Action Items

Action Items

Policy and Procedures for Periodic Assessment of the University President

Presidential Assessment

Consent Item

A. Personnel Report

B. Curriculum Proposals

C. Commercial Lease Agreement - 603 Ransom, Kalamazoo, MI

D. Natural Gas Pipeline Easement at West Hills

E. Membership Change …

Culturally Responsive Social-Emotional Training And Supplemental Resources For Early Childhood Teachers, Danielle Johnson

Masters Projects

Black students are overrepresented in discipline and behavior referrals in the early childhood setting. Given the increasing need for young black children to learn social emotional skills, how can teachers effectively support them with inadequate curriculum? There is significant research that shows the possible reasons why there is an over representation of black students being labeled as a behavior problem in early childhood educational settings. These reasons can create a negative cycle for black students causing much harm to their education and their views of school. Teachers can attempt to resolve this issue by implementing a culturally responsive Social-Emotional Learning …

Performance Evaluation Of Routing Protocols And Ml-Based Enhancements For Uav-Assisted Post-Disaster Communication Networks, Prachi Choudhary

Doctoral Dissertations and Master's Theses

During natural disasters, the existing communication systems collapse, and the disaster-affected areas become disconnected without any means of exchanging information. The collapse of existing communication networks poses challenges for First-Responders (FRs) in locating survivors during Search and Rescue (SAR) operations and for survivors to communicate for emergency aid. To alleviate post-disaster consequences and save lives, Uncrewed Air Vehicles (UAVs), commonly known as drones, can be employed to establish adaptable and reliable emergency communication networks. UAVs offer portability and rapid deployment, making them effective in crises. This thesis presents two main contributions: 1) Evaluation and Comparison of Routing Protocol Performance: The …

Characterizing The Risk Of Meteorite Ejecta To Future Lunar Surface Operations, Jacob Yates

Theses and Dissertations

In-situ materials provided adequate shielding against the risk of meteorite ejecta for future lunar surface operations. Both regolith simulant and simulant-epoxy mixtures stopped simulated ejecta projectiles with velocities at or near lunar escape velocity. Those depth penetrations for those two in-situ related materials were shallow inside 3 cm and may prove to be influential in future mission planning of lunar surface operations. The lunar surface poses a potential risk from meteoroid ejecta for future lunar surface operations. The safety ramifications of long-term crewed missions for the Artemis program, NASA’s lunar program, are being investigated or reconsidered from the previous Apollo …

Silver Bow Creek Butte Area Npl Site 3rd Quarter 2024 Butte Priority Soils Operable Unit Interim Site-Wide Surface Water Monitoring Data Report. Consent Decree- Civil Action No. Cv 89- 039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

25asfc 21st Century Community Learning Centers Grant, Deborah Ivie

Funded Research Records

No abstract provided.

A Conjugate Of An Egfr-Binding Peptide And Doxorubicin Shows Selective Toxicity To Triple-Negative Breast Cancer Cells, Phi-Phung Than, Shih-Jing Yao, Emad Althagafi, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Selective targeting of cancer cells via overexpressed cell-surface receptors is a promising strategy to enhance chemotherapy efficacy and minimize off-target side effects. In this study, we designed peptide 31 (YHWYGYTPERVI) to target the overexpressed epidermal growth factor receptor (EGFR) in triple-negative breast cancer (TNBC) cells. Peptide 31 is internalized by TNBC cells through EGFR-mediated endocytosis and shares sequence and structural similarities with human EGF (hEGF), a natural EGFR ligand. Unlike hEGF, peptide 31 does not induce cell migration in TNBC cells. A novel conjugate of peptide 31 with doxorubicin (Dox) retains selectivity for TNBC cells and exhibits significant toxicity comparable …

The Impact Of Transformational Leadership On Employee Motivation Across Non-Profit And For-Profit Organizations, Kayla L. Lent

M.S. in Leadership

This project examines the impact of transformational leadership on employee motivation within both nonprofit and for-profit organizations. Using a case study approach, the research was inspired by the author’s observations of transformational leadership in practice and its effects on employee engagement, morale, and alignment with organizational goals. A qualitative methodology was employed, featuring a semi-structured interview with a nonprofit leader to explore key components of transformational leadership: idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration. Findings reveal that transformational leadership fosters intrinsic motivation and strengthens organizational culture across sectors. The study concludes with practical recommendations for adopting transformational practices …

Professional Blends, Cameron Neal

Professional Practices (ART 399)

My works explore personal ties to my living environment and need for comfort. Comfort is something that I often think about because I spent so much of my life feeling uncomfortable in my mind and body. My works consist of many materials, but I mainly work in metals and wood, and my process relies heavily on hands-on experimentation. I’ve had experience crafting, but I have never been so meticulous with my work before now.

One of the works I included is a domed ring that mocks the shape of a pillowy or cushioned object even though it is made of …

Professional Practices(Art 399), Ciro Astarita

Professional Practices (ART 399)

The blending of cultures and the fusion of art mediums are both integral components of contemporary art culture. High art, low art, sculpture, fashion, graphic design, animation, traditional drawing and digital illustration are all coming together in today’s world in interesting and unique ways. This parallels my life growing up as an Italian American, one side of my family being from Italy and the other half from America. Growing up, I was inspired by my love of comics and cartoons as well as my frequent trips to Italy and visiting my nonno and nonna. Italy is considered ‘old’ and America …

Estimation Of Prevalence Of Autoimmune Diseases In The United States Using Electronic Health Record Data, Aaron H. Abend, Albert M. Lai, Et Al.

2020-Current year OA Pubs

BACKGROUNDPrevious epidemiologic studies of autoimmune diseases in the US have included a limited number of diseases or used metaanalyses that rely on different data collection methods and analyses for each disease.METHODSTo estimate the prevalence of autoimmune diseases in the US, we used electronic health record data from 6 large medical systems in the US. We developed a software program using common methodology to compute the estimated prevalence of autoimmune diseases alone and in aggregate that can be readily used by other investigators to replicate or modify the analysis over time.RESULTSOur findings indicate that over 15 million people, or 4.6% of …

Genomic Surveillance Of Sars-Cov-2 In Nepal, Binod Khadka, Kathie A Mihindukulasuriya, Lindsay Droit, Anne M Paredes, Scott A Handley, David Wang, Et Al.

2020-Current year OA Pubs

During the COVID-19 pandemic, Nepal, like other countries, faced emerging SARS-CoV-2 variants. To evaluate the circulating variants, 278 samples collected between September 2021 and March 2022 were sequenced in the country. From these, 229 high-quality genomes were obtained (82.97% Omicron and 17.03% Delta) highlighting the genomic diversity of SARS-CoV-2 in Nepal.

12.02.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Email Address Matters

All of Us Researcher Symposium

Welcome Anya Goldman

On The Readership Of Spinoza’S Writing & A Poetics For Thought, Tam Pham

Honors Thesis

This paper invites attention to textual facts and other intricacies in the readership of Spinoza’s writing, which bring to the fore his thinking qua thinking under language, a consideration that seems at least underappreciated, if not misappreciated, by the very readership in question. In so doing, the paper reflects on the possibility—and perhaps necessity—of a poetological purview into a philosophical corpus, in terms of its being written under a sense of Latin as well as of other tongues, generated by and for a thinker to be the linguisticity within which he thinks. To put in differently: if Spinoza were to …

Politics Of Peace: How Social Media Impacts Advocacy In Relation To International Conflict, Madeline Shonholtz, Christopher M. Jackson

Honors Thesis

Social Media is one of the great communicators with hundreds of platforms being used regularly to connect with others, share important life updates, and occasionally see news postings. This paper tackles the question of whether or not social media, with a focus on three platforms: Instagram, Facebook, and X (formerly Twitter), make an impact when it relates to an individual's opinion on International Conflict. Through data comparison and analysis, the answer will be uncovered as to whether or not social media has an impact and if so, how has that impact changed overtime with the comparison of data from 2016 …

Leveraging Machine Learning For Defect Detection In Irrigation Concrete Canal Lining In Egypt: Advancing Construction Quality And Efficiency, Mohamed Nabawy

Civil Engineering

Abstract:

Defects during the construction phase of projects pose significant challenges, particularly in terms of

safety, cost overruns, delays, and labor inefficiencies. In irrigation concrete canal lining construction

with mega investments, early detection of defects is critical to ensuring quality and project success.

This study explores the application of machine learning (ML) for onsite defect detection, focusing

on the development and deployment of an object detection mobile application specifically tailored

for identifying visible defects in concrete canal lining construction. Leveraging the machine learning

capabilities of Microsoft Azure, a custom object detection model was trained and validated to

recognize defects such …

December 12, 2024, The Dakota Student

The Dakota Student

No abstract provided.

The Temporal Construction Of Fossil Fuel Threat In Who Reports: A Corpus-Based Cognitive Pragmatic Study, Nawal M. Abed, Huda H. Khalil

Uruk Journal of Human Sciences

The World Health Organization (WHO) monitors public global health and tries to assist vulnerable populations in their pursue to achieve optimal health. WHO has always voiced concerns regarding health and environmental impacts of fossil fuel consumption. Reviewing WHO website shows various reports on fossil fuel impacts from multiple perspectives. The paper aims to examine the temporal construction of fossil fuel threat in WHO reports. Such construction aims to encourage people to take preventive measures within time span that precedes the impact of the threatening element. To accomplish this aim, the paper employs Cap’s (2013, p. 16) temporal proximization strategy as …

Book Review: Longstreet: The Confederate General Who Defied The South, James "Andy" Nichols

Parameters Bookshelf – Online Book Reviews

Author: Elizabeth R. Varon

Reviewed by Lieutenant Colonel James “Andy” Nichols, US Army War College class of 2024

Lieutenant Colonel James “Andy” Nichols reviews Elizabeth R. Varon’s biography of James Longstreet, which Nichols calls “an engaging, well-researched account of [the general’s] journey through disunion, reconstruction, and reconciliation.” He writes that Varon “lifts Longstreet out of the Lost Cause mythology and, through careful archival work, enables readers understand a man who experienced personal and professional transformation and sought redemption.”

Book Review: Witness To Neptune’S Inferno: The Pacific War Diary Of Lieutenant Commander Lloyd M. Mustin, Uss Atlanta (Cl 51), Jonathan Klug

Parameters Bookshelf – Online Book Reviews

Author: David F. Winkler

Reviewed by Colonel Jonathan Klug (US Army), PhD, associate dean, associate professor, and Admiral William F. Halsey Chair of Naval Studies, US Army War College

Colonel Jonathan Klug (PhD), the US Army War College’s Admiral William F. Halsey Chair of Naval Studies, identifies David F. Winkler’s contribution to the field with this book. Klug writes, “Winkler adds tremendous value to [Lloyd M.] Mustin’s comments by placing them into their proper historical context and providing insight into the development of a mid-career naval officer into a strategic leader.” Klug also notes that “this book would be especially …