Digital Commons Network^™

Structural Variant Allelic Heterogeneity In Mecp2 Duplication Syndrome Provides Insight Into Clinical Severity And Variability Of Disease Expression, Davut Pehlivan, Marwan S Shinawi, Et Al.

2020-Current year OA Pubs

BACKGROUND: MECP2 Duplication Syndrome, also known as X-linked intellectual developmental disorder Lubs type (MRXSL; MIM: 300260), is a neurodevelopmental disorder caused by copy number gains spanning MECP2. Despite varying genomic rearrangement structures, including duplications and triplications, and a wide range of duplication sizes, no clear correlation exists between DNA rearrangement and clinical features. We had previously demonstrated that up to 38% of MRXSL families are characterized by complex genomic rearrangements (CGRs) of intermediate complexity (2 ≤ copy number variant breakpoints <  5), yet the impact of these genomic structures on regulation of gene expression and phenotypic manifestations have not been investigated.

METHODS: To study the role of the genomic rearrangement structures on an individual's clinical phenotypic variability, we employed a comprehensive …

Microglial Cd2ap Deficiency Exerts Protection In An Alzheimer's Disease Model Of Amyloidosis, Lingliang Zhang, David M. Holtzman, Et Al.

2020-Current year OA Pubs

BACKGROUND: The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton and protein trafficking. Single nucleotide polymorphisms (SNPs) in the CD2AP gene have been associated with Alzheimer's disease (AD). However, the functional role of CD2AP, especially its role in microglia during AD onset, remains elusive.

METHODS: CD2AP protein levels in cultured primary cells and in 5xFAD mice was studied. Microglial CD2AP-deficient mice were crossed with 5xFAD mice and the offspring were subjected to neuropathological assessment, behavioral tests, electrophysiology, RNA-seq, Golgi staining, and biochemistry analysis. Primary microglia were also isolated for assessing their uptake and morphology changes. …

Primary Anorectal Mammary-Like Adenocarcinoma: A Potential Diagnostic Pitfall With Conventional Colorectal Adenocarcinoma, Margaret L Axelrod, Xiuli Liu, Pooja Navale

2020-Current year OA Pubs

Anogenital mammary-like glands (AGMLGs) are present in the anogenital region that bear striking morphologic and protein-expression similarities to mammary glands in the breast. AGMLGs can give rise to both benign and malignant lesions which mimic primary breast lesions. Herein, we report two mammary-type adenocarcinomas arising from AGMLGs, including one in the previously unreported site of the rectum. Recognition of mammary-type adenocarcinoma in the rectal and anogenital regions is crucial as clinical management options may differ compared to conventional colorectal adenocarcinomas.

The Improving Treatment Decisions For Patients With Aortic Stenosis Through Shared Decision Making (Impact Sdm) Study: Study Protocol For A Cluster Randomized Stepped Wedge Trial, Karen Sepucha, Nishath Quader, Alexander A Brescia, Et Al.

2020-Current year OA Pubs

BACKGROUND: The American College of Cardiology, American Heart Association, and Centers for Medicare and Medicaid Services recommend shared decision-making (SDM) for patients with severe aortic stenosis choosing between transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). Although tools such as patient decision aids (DAs) and training in SDM have been shown to improve SDM, implementation of SDM and DAs is limited. The IMproving treatment decisions for Patients with AortiC stenosis Through Shared Decision Making (IMPACT SDM) study aims to (1) determine the effectiveness of the interventions (a DA and clinician SDM training) in achieving SDM (primary outcome) …

Addressing Lung Truncation In 99mtc-Maa Spect/Ct For 90y Microsphere Radioembolization Treatment Planning, M Allan Thomas, Richard Laforest, John Karageorgiou, Dan Giardina, Tyler J Fraum, Chris D Malone, Justin K Mikell

2020-Current year OA Pubs

BACKGROUND: Prior studies have established that macroaggregated albumin (MAA)-SPECT/CT offers more robust lung shunt fraction (LSF) and lung mean absorbed dose (LMD) estimates in

METHODS: Lung truncation was simulated in 56 cases with adequate (> 90%, mean: 98%) lung coverage in MAA-SPECT/CT by removing slices in ~ 5 mm increments from the lung apices to the diaphragm. A wide range of lung coverages from 100% to <  1% in ~ 2% increments were created. LSF and LMD were calculated with four methods. (1) 2D planar imaging standard (not truncated), truncated lung SPECT/CT data was: (2) used with no corrections (SPECT

RESULTS: Averaged across simulated lung coverages from 40 to 80%, percent errors relative to non-truncated data for SPECT

CONCLUSION: LSF and LMD can be estimated for

The Biomechanics Of Fibrillin Microfibrils: Lessons From The Ciliary Zonule, Pooja Rathaur, Juan Rodriguez, John Kuchtey, Samuel Insignares, Wendell B Jones, Rachel W Kuchtey, Steven Bassnett

2020-Current year OA Pubs

Marfan syndrome is an inherited connective tissue disorder that affects the cardiovascular, musculoskeletal, and ocular systems. It is caused by pathogenic variants in the fibrillin-1 gene (

Factors Affecting Sport-Related Concussion Non-Disclosure In Women's Rugby-A Multi-Country Qualitative Analysis, Lisa Ryan, Ed Daly, Katherine Hunzinger

Department of Exercise Science Faculty Papers

Background and Objectives: Collision-sport athletes, such as rugby players, are at risk of sport-related concussion (SRC). Women are known to be at higher risk of SRC and may experience more severe and chronic symptomology than men. Knowledge of the factors that affect a player’s disclosure of their concussive symptoms could help to inform strategies to improve compliance with reporting and management of head injuries. The aim of this study was to investigate the factors that may impact women rugby players’ disclosure of a concussion. Methods: Twenty-eight adult (≥18 years of age) elite and semi-elite women rugby players from the UK …

A Topological Route To Engineering Robust And Bright Supersymmetric Laser Arrays, Soujanya Datta, Mohammad Alizadeh Fard, Ramy El-Ganainy, Krishanu Roychowdhury

Michigan Tech Publications

In recent years, several proposals that leverage principles from condensed matter and high-energy physics for engineering laser arrays have been put forward. The most important among these concepts are topology, which enables the construction of robust zero-mode laser devices, and supersymmetry (SUSY), which holds the potential for achieving phase locking in laser arrays. In this work, we show that the relation between supersymmetric coupled bosonic and fermionic oscillators on one side, and bipartite networks (and hence chiral symmetry) on another side can be exploited together with non-Hermitian engineering for building one- and two-dimensional laser arrays with in-phase synchronization. To demonstrate …

Working Within A Perfect Storm: The Current Uk Care Crisis In Community Neurorehabilitation, Alyson Norman, Mark Holloway, Jackie Dean, Andrew Patterson, Ben Needham-Holmes, Valentina Curro, Craig Andrews, Phillipa Feltham-White, Jo Clark-Wilson

School of Psychology

Context: Within the UK there is a shortage of support workers required to meet the needs of individuals with acquired brain injuries who often require extensive care packages. Objective: This study aimed to identify the issues surrounding support worker recruitment and retention and to identify the impact on the care received by individuals with brain injuries and other complex needs. Method: Two surveys were sent out to members of the British Association of Brain and Complex Case Management (BABICM) to better understand retention and recruitment issues within their organisations. Cross-sectional data were collected in January 2022 and again in April …

Social Learning And Cultural Enrichment For Fish Welfare, Chiawen Chiang, Becca Franks

Animal Sentience

This commentary examines how understanding animal culture—shared behaviors and knowledge transmitted through social learning—plays a role in advancing welfare practices for captive fishes. Despite extensive evidence of fishes' complex sociocultural capacities, their psycho-social needs remain underestimated and unmet in zoos and aquaria. We explore what considering fish culture might mean for welfare practices: diverse social learning opportunities, cultural development, and thoughtful group management. More knowledge about wild fishes' lives will help bridge the gap between their full, complex lives and current captive welfare practices.

Beyond The Surface: Understanding Temperature Polarisation In Dcmd Membranes Through Varied Operational Parameters, Hiras Ahamed Hijaz, Masoumeh Zargar, Abdellah Shafieian, Amir Razmjou, Mehdi Khiadani

Research outputs 2022 to 2026

Conventionally, a single Temperature Polarisation Coefficient (TPC) value is calculated to quantify Temperature Polarisation (TP). In this research, the extent of polarisation is investigated by capturing temperature profiles at specific points along a MD membrane using miniature thermocouples, eliminating the need for TPC calculations. The extent of polarisation at a point is affected by two contributory factors, namely the proximity of flow inlets and the difference in vapour pressure across the membrane at that point. Under this direction, this work examined the influence of permeate temperature, feed salinity, and flow direction on the development of the temperature profiles. Our analysis …

Exploring The Relationship Between Hand Grip Strength And Handwriting Proficiency, Chloe Fields, Rebecca King

Fall 2024 OTD Capstone Symposium

Handwriting remains essential for a child's academic performance despite the rise of technology in classrooms, but overuse of digital tools can hinder the development of essential hand muscles and fine motor skills. This capstone project explores the relationship between handwriting proficiency, hand grip strength, and the impact of excessive technology use on young students.

Mild Traumatic Brain Injuries In Justice-Involved Individuals And Executive Function Consequences On Transition And Reentry Into The Community ​, Alaina L. Randerson, Michael Sutcliffe, Cassandra Nelson, Ariana Gonzalez

Fall 2024 OTD Capstone Symposium

The United States has the highest documented incarceration rate in the world (Carson, 2022), with an increasing number of justice-involved individuals (JII) potentially affected by mild traumatic brain injury (mTBI). Despite the high prevalence of mTBIs in the general population, limited research exists on the prevalence and impact of mTBIs in JII. Preliminary evidence suggests that the prevalence of mTBIs in incarcerated individuals is 50 times higher than in the general public (Siegler et al., 2017). This study aimed to explore the lived experiences of JII with mTBI, focusing on the origin of mTBIs, executive dysfunction, and the occupational barriers …

Agot: Agricultural Guide For Occupational Therapy Practitioners, Kara Smallegan, Meghan Skidmore Otd, Otr, Cns, Angela Labrie Blackwell Phd, Otr

Fall 2024 OTD Capstone Symposium

As agriculture is a hazardous occupation, this project discusses agricultural workers with health conditions/disabilities, experiencing disruption to occupational performance and participation, increasing risk of secondary injuries, and impacting overall well-being and how occupational therapy practitioners can improve these factors through the development of a guidebook. The guide covers population insights, risk factors, assessment guide, conditions, and resources to aid occupational practitioners when assisting the agricultural worker population.

Preoperative Education For Total Hip And Knee Replacements, Molly Whitehead, Cassandra Nelson, Gwen Morris

Fall 2024 OTD Capstone Symposium

An educational program has been developed to implement with total hip or knee replacement patients prior to their procedure to improve function with ADLs, lessen the need for caregiver assistance, and to increase patient satisfaction.

Navigating Life After The Nicu: A Developmental Guide For Preterm And High-Risk Infants And Toddlers, Reagan Lachaussee, Mary Jan Greer Phd, Otr, Theresa Mensi

Fall 2024 OTD Capstone Symposium

Premature and medically fragile infants are at high risk for developmental delays and benefit from ongoing support. Parents often feel overwhelmed and uncertain about how to support their child’s development at home. This project addressed gaps in caregiver education and support by developing the PEARLS Program (Promoting Early Achievements, Resilience, and Life Skills), a practical resource tailored to the needs of families and healthcare providers.

A needs assessment and provider feedback guided the program’s development, identifying challenges such as information overload, confusion around corrected age, and feeding difficulties. The PEARLS Program empowers families with digestible, actionable resources, including …

Older Adult's Fall Prevention Program, Myles Butler, Rebecca King

Fall 2024 OTD Capstone Symposium

The decline in bodily functions with aging increases older adults' vulnerability to falls, which is a leading cause of death within this population. The poster presents an educational based fall prevention program focused on safety awareness and risk management for older adults. In conclusion, implementing a fall prevention program leads to increased awareness regarding risk factors that are detrimental to the safety and well-being of the older adult community

Ergonomics & Environmental Changes Within The Beauty Industry To Decrease Musculoskeletal Conditions, Jessika Eiland, Rebecca King

Fall 2024 OTD Capstone Symposium

Ergonomics, adaptation, and environmental changes within the beauty industry to decrease musculoskeletal conditions in the upper extremities. Musculoskeletal disorders and their effects may limit a hairdressers ability to complete their job duties. For individuals within the beauty industry, health management can become an important factor.

Making An Easy Return To School After An Extended Illness Diagnosis, Ashlyn Eads, Mary Jan Greer, Julie Boykin

Fall 2024 OTD Capstone Symposium

This poster provides information on the capstone program created at a pediatric site. This program addresses how play-based therapy can help children with an extended illness transition back into the school setting. Both the children and their caregivers need support before, during, and after the return to school. The goals of this program were to educate caregivers on how to advocate for their child for positive outcomes, provide caregivers with resources to promote successful transition to school, provide play-based strategies for children addressing handwriting, social Skills, upper body strength, education, fine Motor Skills, and provide the site and caregivers with …

Helping Children With Adhd Thrive At Home And In The Classroom, Lindsey Lott, Mary Greer, Lisa Griggs-Stapleton

Fall 2024 OTD Capstone Symposium

Attention-Deficit/Hyperactivity Disorder (ADHD) is the most common neurobiological disorder in the U.S. Yet, 69% of parents and 70% of teachers feel underprepared in their ability to support children with ADHD (Miller, 2021; Asherson, 2024). This capstone program aimed to address this issue by creating a strengths-based, family-centered program rooted in the Ayres Sensory Integration framework, designed for caregivers and teachers of children with ADHD (Ayres, 2005). Conducted at a pediatric outpatient clinic, nearly 40 parents /caregivers and teachers of children with ADHD participated in this program. Participants received an ongoing educational experience covering topics such as the neurology and neuronal …

Development Of A Virtual Reality Program To Promote Occupational Participation And Decreased Psychosocial Deficits In Persons With A Brain Injury, Nicole Arneson, Rebecca King

Fall 2024 OTD Capstone Symposium

Stroke is one of the leading causes of disabilities including problems with balance, muscle weakness, abnormal muscle tone, mental health, as well as deficits in visual function and sensory function The purpose of this capstone is to develop a virtual reality program that will be used with the stroke population to address ADLs, IADLs, and quality of life.

Occupational Therapy Role In Aiding Health Management For Caregivers Of Children With Neurological Conditions, Peyton Mcgee, Mary Jan Greer, Caitlin Boyd

Fall 2024 OTD Capstone Symposium

Neurological disorders are identified as a dysfunction on any part of the nervous system that cause disability (Kumar et al., 2022). In order to enhance the outcome of children with neurological conditions, there should be an emphasis on the role and well-being of their caregivers. Common symptoms of neurological disorders among children include delayed developmental milestones, seizures and epilepsy, regression of skills, abnormal movements and behaviors, headaches, sensory processing issues, and communication difficulties. Adjusting to a new normal can be overwhelming for caregivers, especially when children transition out of rehab. The aim of the proposed capstone project is to aid …

Improving Adls, Iadls, And Qol In Breast Cancer Survivors, Tincy Samuel, Rebecca King

Fall 2024 OTD Capstone Symposium

Breast cancer and its treatment can significantly impact breast cancer survivor’s ability to perform Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), and Quality of Life (QoL). Physical activity programs have been found to positively impact various aspects of quality of life in breast cancer patients, including physical condition, state of mind, and selfesteem. However, there is a gap in the OT practice and the literature regarding how to improve independence in ADLs, IADLs, and overall quality of life in breast cancer survivors. A program was created to improve Activities of Daily Living (ADLs), Instrumental Activities of …

Type 2 Diabetes Mellitus Health Management Within The Adult Population: A Road Toward Occupational Engagement, Valeria Martinez, Cassandra Nelson, Otd, Otr/L, Mba, Cns, Ceas I

Fall 2024 OTD Capstone Symposium

Approximately 37 million Americans have been diagnosed with Type 2 Diabetes Mellitus (T2DM) (CDC, 2023). As a result, DM is ranked as the eighth leading cause of mortality in the United States, yet the management of symptoms and overall condition is frequently neglected by a significant portion of the American population (CDC, 2023). A contributing factor to this issue is the insufficient access to resources for underserved communities, particularly among the Hispanic population with low health literacy. This capstone project focuses on health management and educating the adult population with a goal of enhancing activities of daily living (ADL) and …

Evaluations Of Digital Public Health Interventions In The Who Southeast Asia Region: A Systematic Literature Review, Nachiket Gudi, Elstin Anbu Raj, Beate Jahn, Uwe Siebert

Open Access archive

Introduction Digital health technologies have been enhancing the capacity of healthcare providers and, thereby, the delivery of targeted health services. The Southeast Asia Region (SEAR) has invested in strengthening digital public health. Many digital health interventions have been implemented in public health settings but are rarely assessed using the holistic health technology assessment (HTA) approach. Methods A systematic literature review was performed to provide an overview of evaluations of digital public health interventions in the World Health Organization (WHO) SEAR. Searches were conducted on four electronic databases. Screening title abstracts and full texts was independently conducted by two reviewers, followed …

Rêvê La Drame, Pranjal Yogendra Sawai

Theses

Rêvê La Drame envisions the future of luxury branding by merging Audrey Hepburn's timeless elegance with the transformative capabilities of augmented reality (AR). This thesis addresses the growing demand for immersive and personalized consumer experiences, proposing a pioneering model that integrates traditional design principles with advanced technology to redefine engagement in the fashion industry. The project includes an innovative identity system featuring cinematic storytelling and AR interactions, such as a giant virtual shopping bag installation showcased at flagship locations like the MET. This thesis presents Rêve La Drame as a transformative approach to branding in the evolving luxury fashion landscape …

Rental Property Demand And Supply Analysis Using Machine Learning, Ahmed Amiri

Theses

The real estate market in Dubai is famous for its activity and stimulating potential due to the geographical position of the emirate, well-developed transport and legal framework. Timely determination and prediction of rental price is crucial for investors, property owners and managers, tenants and authorities in their decision making to maximize returns and ensure market stability. Traditional approaches are insufficient for the analysis of the temporal and spatial relations between property characteristics and market processes, which require the use of sophisticated machine learning algorithms. This paper aims to predict the rental prices of properties in Dubai using machine learning models …

Amorfe: An Ai-Integrated Interactive Brainstorming Interface, Ipshita Pal

Theses

Amorfe is an interactive multi-touch digital interface that reimagines brainstorming and collaboration using artificial intelligence (AI). Designed to make ideation more dynamic, the platform allows participants to explore, merge, and refine ideas in real time. AI is a creative catalyst, offering unpredictable outcomes and streamlining the brainstorming process. This makes Amorfe engaging, intuitive, and inclusive, encouraging active participation. The platform’s potential was demonstrated through a hypothetical scenario: “How do we create more green spaces on the RIT campus?” Four participants explored various brainstorming phases through touch interaction, leading to the creation of a prototype simulation video and a promotional video. …

Dissonance, Shreya Talegaonkar

Theses

Cognitive dissonance represents a profound psychological phenomenon where conflicting beliefs create mental tension. My thesis, Dissonance, transforms this abstract concept into an immersive multimedia installation that visually explores the human mind's intricate journey of reconciling internal contradictions. Using Cinema 4D, Adobe AfterEffects, and Resolume Arena, the project creates dynamic 3D animations projection-mapped across an 8x8x6 cubic feet space. Carefully designed blackout curtains and strategic seating immerse participants in a transformative narrative of psychological exploration. Audiences navigate through four distinct phases: Consistency, Chaos, Turmoil, and Adaptation. Each phase invites viewers to experience the unsettling yet profound journey of internal conflict resolution, …

Pyrophosphate-Free Glycolysis In Clostridium Thermocellum Increases Both Thermodynamic Driving Force And Ethanol Titers, Bishal Dev Sharma, Shuen Hon, Eashant Thusoo, David M. Stevenson, Daniel Amador-Noguez, Adam M. Guss, Lee R. Lynd, Daniel G. Olson

Dartmouth Scholarship

Background

Clostridium thermocellum is a promising candidate for production of cellulosic biofuels, however, its final product titer is too low for commercial application, and this may be due to thermodynamic limitations in glycolysis. Previous studies in this organism have revealed a metabolic bottleneck at the phosphofructokinase (PFK) reaction in glycolysis. In the wild-type organism, this reaction uses pyrophosphate (PPi) as an energy cofactor, which is thermodynamically less favorable compared to reactions that use ATP as a cofactor. Previously we showed that replacing the PPi-linked PFK reaction with an ATP-linked reaction increased the thermodynamic driving force of glycolysis, but only had …