Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2024

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 3301 - 3330 of 193062

Full-Text Articles in Entire DC Network

Using Bivalves As An Indicator For Fecal Bacteria, Kamala Chuss Dec 2024

Using Bivalves As An Indicator For Fecal Bacteria, Kamala Chuss

Honors Scholar Theses

This project focuses on the integration of fecal bacteria from warm-blooded animals into bivalve tissue, and the utilization of bivalves as an indicator for fecal bacteria in waterways. Bivalves may give a more representative long-term average of fecal bacteria in water as compared to direct water testing. The primary objective is to create a standard operating procedure to use bacterial testing of bivalves as a proxy for bacteria concentration in the water. This method can be used in places where bivalves do not already exist by adding them to a body of water, or by collecting bivalves that already exist …


Grain Boundary Solute Segregation Across The 5d Space Of Crystallographic Character, Lydia Harris Serafin Dec 2024

Grain Boundary Solute Segregation Across The 5d Space Of Crystallographic Character, Lydia Harris Serafin

Theses and Dissertations

Solute segregation in materials with grain boundaries (GBs) has emerged as a popular method to thermodynamically stabilize nanocrystalline structures. However, the impact of varied GB crystallographic character on solute segregation has never been thoroughly examined. This work examines Co solute segregation in a dataset of 7272 Al bicrystal GBs that span the 5D space of GB crystallographic character. Considerable attention is paid to verification of the calculations in the diverse and large set of GBs. In addition, the results of this work are favorably validated against similar bicrystal and polycrystal simulations. As with other work, we show that Co atoms …


Social Status, Economic Development And Female Labor Force (Non) Participation, Kaivan Munshi, Swapnil Singh Dec 2024

Social Status, Economic Development And Female Labor Force (Non) Participation, Kaivan Munshi, Swapnil Singh

Cowles Foundation Discussion Papers

This research provides a status-based explanation for the high rates of female labor force nonparticipation (FLFNP) and the sustained increase in these rates over time that have been documented in many developing economies. This explanation is based on the idea that households or ethnic groups can signal their wealth, and thereby increase their social status, by withdrawing women from the labor force. If the value of social status or the willingness to bear the signaling cost is increasing with economic development, then this would explain the persistent increase in FLFNP. To provide empirical support for this argument, we utilize two …


Staff Education Project Staff Education To A Medical Surgical Unit, Kay-Ann Wilson-Phipps Dec 2024

Staff Education Project Staff Education To A Medical Surgical Unit, Kay-Ann Wilson-Phipps

Walden Dissertations and Doctoral Studies

This Doctor of Nursing (DN) project aimed to educate staff on set protocols for preventing catheter-associated urinary tract infection (CAUTI) in a medical-surgical unit. The CAUTI rates in the unit were rising beyond the national standards. The purpose of this project was to effectively reduce the CAUTI rates by at least 25% by providing knowledge in the form of best practices to the nursing staff about catheter insertion, care, and removal. The practice-focused question attempted to answer whether staff education on CAUTI protocols would increase knowledge. Thirty-seven staff members voluntarily participated in the education project, including nursing staff, infection control …


Exploring Kindergarten Teachers' Perspectives On The Interpretation Of Standards In A Developmentally Appropriate Way In Kindergarten Classrooms, Shawanza Demetrist Lockett Dec 2024

Exploring Kindergarten Teachers' Perspectives On The Interpretation Of Standards In A Developmentally Appropriate Way In Kindergarten Classrooms, Shawanza Demetrist Lockett

Walden Dissertations and Doctoral Studies

Many kindergarten teachers are feeling the effects of standard-based education. The problem is that it is unknown whether teachers implement mandated state standards in a developmentally appropriate way. The purpose of this basic qualitative study was to investigate kindergarten teachers’ perspectives on implementing standards in a developmentally appropriate manner. Shulman’s theory of teacher knowledge was the conceptual framework for the study. The research question focused on kindergarten teachers’ perspectives of implementing standards in a developmentally appropriate way. Twelve kindergarten teachers were recruited from three Title 1 elementary schools in a rural southeastern state in the United States. Thematic data analysis …


Suicide Risk Assessment And Student Competency In Cacrep-Accredited Master's Counseling Programs, Meghan Kyle O'Meara Dec 2024

Suicide Risk Assessment And Student Competency In Cacrep-Accredited Master's Counseling Programs, Meghan Kyle O'Meara

Walden Dissertations and Doctoral Studies

Suicide remains a public health issue, demanding proficient training of future counselors in suicide risk assessment (SRA). However, concerns persist regarding the competency of counselors-in-training (CITs) in this crucial area. This study explored the predictive relationship between theory of planned behavior (TPB) constructs and students’ perceived competency in SRA. Grounded in the TPB, the research addressed how attitudes (ATT), subjective norms (SN), and perceived behavioral control (PBC) influence intentions and subsequent behavior, using a nonexperimental survey design to collect data from students in Council for Accreditation of Counseling & Related Educational Programs (CACREP)–accredited master's counseling programs via a comprehensive questionnaire. …


Reducing Attrition In Medication-Assisted Treatment: Strategies From Behavioral Health Leaders, Tony Shaw Dec 2024

Reducing Attrition In Medication-Assisted Treatment: Strategies From Behavioral Health Leaders, Tony Shaw

Walden Dissertations and Doctoral Studies

This qualitative case study explores strategies to reduce attrition rates in medication-assisted treatment programs, drawing on the perspectives of behavioral health leaders and guided by the principles of the Baldridge Excellent Framework. It aims to implement effective strategies to enhance client retention and improve treatment outcomes. Drawing from 18 years of professional experience in behavioral health, this research analyzes current practices and identifies interventions to improve program effectiveness. Data collection includes case studies, surveys, and interviews with behavioral health leaders, providing a comprehensive view of the challenges and opportunities within these programs. The study revealed several key factors affecting retention …


The Psychological And Physical Impact Of The Opioid Crisis On Families, Adrienne Antoinette Hunter Wells Green Dec 2024

The Psychological And Physical Impact Of The Opioid Crisis On Families, Adrienne Antoinette Hunter Wells Green

Walden Dissertations and Doctoral Studies

Many rural areas in the United States have experienced an opioid crisis. Social support programs could be created to address social support for the families affected by opioid addiction. The purpose of this non-experimental, cross-sectional research study was to examine the possible relationship between (a) prescription or non-prescription addiction; (b) opioid addiction or another addiction; (c) the amount of family social support of a family member who has ongoing interactions with the individual struggling with addiction; and (d) stress of the family member in a rural area. Bowen’s family systems theory provided the theoretical framework for the study. A non-probability …


Invasion Stress Mitigates Climate Stress In A Brackish Marsh Amphipod, Lorna E. Haworth, Sarah Nancollas, Susie N. Landa, Anne E. Todgham, Richelle L. Tanner Dec 2024

Invasion Stress Mitigates Climate Stress In A Brackish Marsh Amphipod, Lorna E. Haworth, Sarah Nancollas, Susie N. Landa, Anne E. Todgham, Richelle L. Tanner

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

  1. Organisms in coastal brackish ecosystems face not only highly variable environmental conditions, but the intensity and stochasticity of these environmental conditions are anticipated to increase due to climate change. While environmental changes are often presented unilaterally as stressors, there are some anthropogenic environmental transformations, such as the introduction of habitat forming plant species, that may mitigate physiological stress imposed by warming. In Suisun Marsh in the California Delta, native plant canopies allow light and heat to penetrate to the understory yet the canopies of the introduced Phragmites australis reed block out sunlight and heat for organisms living below.
  2. We set …


Reversing Chronic Disease Through Functional Medicine: Acknowledging Privilege And Seeking Justice, Rosalynn A. Vega Dec 2024

Reversing Chronic Disease Through Functional Medicine: Acknowledging Privilege And Seeking Justice, Rosalynn A. Vega

Anthropology Faculty Publications

This piece is based on twenty-eight months of digital-auto-ethnographic research. While my research methods included traditional ethnographic research in face-to-face settings and digital ethnography, my personal experience is also embedded in the work. In this piece, you will find “interludes” that provide glimpses into my healing journey. When writing in this autoethnographic register, I provide “thick descriptions” (Geertz 3) of how I experienced illness and recovery. By including my own story, I am acknowledging that the observed and the observer are inextricably intertwined. All ethnography is relational. Ethnographic data results from a trusting relationship between ethnographer and participant. Furthermore, in …


On The Power Series Method For Solitons And Peakons Of Nonlinear Pde, Erika Olivares, Vesselin Vatchev Dec 2024

On The Power Series Method For Solitons And Peakons Of Nonlinear Pde, Erika Olivares, Vesselin Vatchev

School of Mathematical & Statistical Sciences Faculty Publications

In this paper we discuss the power series method to obtain traveling wave solutions of nonlinear PDE in one space variable. The method, including a recursive procedure for the coefficients and error estimate for the partial sums, is presented for the Camassa-Holm equation. Numerical examples of approximate single soliton and single peakon solutions are included.


Legacy Effects Of Crop Diversity On Weed-Crop Competition In Maize Production, Uriel D. Menalled, K Ann Bybee-Finley, Richard G. Smith, Antonio Ditommaso, Heather M. Darby, Sarah J. Pethybridge, Matthew R. Ryan Dec 2024

Legacy Effects Of Crop Diversity On Weed-Crop Competition In Maize Production, Uriel D. Menalled, K Ann Bybee-Finley, Richard G. Smith, Antonio Ditommaso, Heather M. Darby, Sarah J. Pethybridge, Matthew R. Ryan

Faculty Publications

The legacy effects of crop diversity on maize (Zea mays L.) tissue nutrient composition, weed community structure, and intensity of weed-crop competition were assessed through a field experiment at two sites in the northeastern United States. Fields were conditioned with crop diversity gradients from summer 2016 to spring 2019. The crop diversity gradients ranged from a single cultivar to sixteen intercropped cultivars (four species, four cultivars per species) and were established in organic annual and perennial cropping systems. Following the three-year conditioning phase, maize was planted across the entire experiment, and each conditioning-phase diversity treatment was split into weed-free, ambient-weed, …


Long-Term Measurements Of Seasonal Snowpacks Indicate Increases In Mid-Winter Snowmelt And Earlier Snowpack Disappearance In The Northeastern U.S., Geoff Wilson, Mark Green, John Campbell, Alexandra R. Contosta, Nina Lany, Amey Bailey Dec 2024

Long-Term Measurements Of Seasonal Snowpacks Indicate Increases In Mid-Winter Snowmelt And Earlier Snowpack Disappearance In The Northeastern U.S., Geoff Wilson, Mark Green, John Campbell, Alexandra R. Contosta, Nina Lany, Amey Bailey

Faculty Publications

Snowpacks are changing in northeastern North America as the regional climate warms, yet the relative influence of changes in precipitation compared to changes in ablation on snowpacks is poorly understood. We use 56 years of weekly snow water equivalent (SWE) measurements from three locations within a study site which vary in elevation and aspect, paired with adjacent daily climate measurements, to investigate relationships between climate and snowpack onset, maximum, and disappearance. Maximum snowpack size and snowpack duration are shrinking at all sites, at rates ranging from 4.3 days/decade at the coldest site to 9.6 days/decade at the warmest site. The …


Legacy Effects Of Crop Diversity On Weed-Crop Competition In Maize Production, Uriel D. Menalled, K Ann Bybee-Finley, Richard G. Smith, Antonio Ditommaso, Heather M. Darby, Sarah J. Pethybridge, Matthew R. Ryan Dec 2024

Legacy Effects Of Crop Diversity On Weed-Crop Competition In Maize Production, Uriel D. Menalled, K Ann Bybee-Finley, Richard G. Smith, Antonio Ditommaso, Heather M. Darby, Sarah J. Pethybridge, Matthew R. Ryan

Faculty Publications

The legacy effects of crop diversity on maize (Zea mays L.) tissue nutrient composition, weed community structure, and intensity of weed-crop competition were assessed through a field experiment at two sites in the northeastern United States. Fields were conditioned with crop diversity gradients from summer 2016 to spring 2019. The crop diversity gradients ranged from a single cultivar to sixteen intercropped cultivars (four species, four cultivars per species) and were established in organic annual and perennial cropping systems. Following the three-year conditioning phase, maize was planted across the entire experiment, and each conditioning-phase diversity treatment was split into weed-free, ambient-weed, …


Long-Term Measurements Of Seasonal Snowpacks Indicate Increases In Mid-Winter Snowmelt And Earlier Snowpack Disappearance In The Northeastern U.S., Geoff Wilson, Mark Green, John Campbell, Alexandra R. Contosta, Nina Lany, Amey Bailey Dec 2024

Long-Term Measurements Of Seasonal Snowpacks Indicate Increases In Mid-Winter Snowmelt And Earlier Snowpack Disappearance In The Northeastern U.S., Geoff Wilson, Mark Green, John Campbell, Alexandra R. Contosta, Nina Lany, Amey Bailey

Faculty Publications

Snowpacks are changing in northeastern North America as the regional climate warms, yet the relative influence of changes in precipitation compared to changes in ablation on snowpacks is poorly understood. We use 56 years of weekly snow water equivalent (SWE) measurements from three locations within a study site which vary in elevation and aspect, paired with adjacent daily climate measurements, to investigate relationships between climate and snowpack onset, maximum, and disappearance. Maximum snowpack size and snowpack duration are shrinking at all sites, at rates ranging from 4.3 days/decade at the coldest site to 9.6 days/decade at the warmest site. The …


Unraveling The Relationship Between Sleep Behaviors And Physical Activity In The United States: Insights From 2015 To 2020 Nhanes Data, Deepali K Ernest, Bipin Singh, Fathimath Shamna, Elizabeth A Onugha, Shreela V Sharma Dec 2024

Unraveling The Relationship Between Sleep Behaviors And Physical Activity In The United States: Insights From 2015 To 2020 Nhanes Data, Deepali K Ernest, Bipin Singh, Fathimath Shamna, Elizabeth A Onugha, Shreela V Sharma

Faculty, Staff and Student Publications

Background: Physical activity is an important component of metabolic health. However, little is known about the impact of specific types/intensities of physical activity on sleep health, especially among ethnically diverse populations. We examined the association of various sleep behaviors with moderate to vigorous work/recreational activity.

Methods: Self-reported data from the National Health and Nutrition Examination Survey 2015-2020 were cross-sectionally analyzed for a sample of 11,039 participants in the United States (U.S.). Weighted univariate logistic regressions determined unadjusted associations, while weighted multivariable regression models adjusting for age, sex, ethnicity, BMI categories, and socio-economic status assessed the multivariable associations with moderate and …


Oculomotor Nerve Palsy Recovery Following Microsurgery Vs. Endovascular Treatment Of Posterior Communicating Artery Aneurysms: A Comparative Meta-Analysis Of Short- And Long-Term Outcomes, Rahim Abo Kasem, Conor Cunningham, Sameh Samir Elawady, Mohammad Mahdi Sowlat, Sofia Babool, Saad Hulou, Zachary Hubbard, Atakan Orscelik, Basel Musmar, Alejandro Spiotta Dec 2024

Oculomotor Nerve Palsy Recovery Following Microsurgery Vs. Endovascular Treatment Of Posterior Communicating Artery Aneurysms: A Comparative Meta-Analysis Of Short- And Long-Term Outcomes, Rahim Abo Kasem, Conor Cunningham, Sameh Samir Elawady, Mohammad Mahdi Sowlat, Sofia Babool, Saad Hulou, Zachary Hubbard, Atakan Orscelik, Basel Musmar, Alejandro Spiotta

Department of Neurosurgery Faculty Papers

Recent advancements in endovascular treatment (EVT) and different views on optimal management for posterior communicating artery (PComA) aneurysms with oculomotor nerve palsy (ONP) highlight a need to compare recovery timelines between microsurgery and EVT; heterogeneous outcomes and influencing factors may also affect results. A comprehensive systematic review and meta-analysis were conducted by searching PubMed, Embase, Scopus, and Web of Science databases. The extracted data encompassed patient demographics, details on treatment modalities and timing, and characteristics of PComA aneurysms ONP caused by either unruptured or ruptured aneurysms. The primary outcome was ONP favorable recovery, defined as the resolution of admission symptoms, …


Aspiration Of Left Atrial Masses Using The Large-Bore Manual Aspiration System: The Aspirate La Procedure, Shaurya Srivastava, Hussam Al Hennawi, Ahmad Abulshamat, Appa Bandi, Mohammed Qintar Dec 2024

Aspiration Of Left Atrial Masses Using The Large-Bore Manual Aspiration System: The Aspirate La Procedure, Shaurya Srivastava, Hussam Al Hennawi, Ahmad Abulshamat, Appa Bandi, Mohammed Qintar

Abington Jefferson Health Papers

Transcatheter mass extraction of left-sided cardiac masses has gained popularity in recent years, with scarce data on effectiveness, safety, and types of devices used. Mostly, left-sided aspirations use mechanical and continuous-flow–mediated devices (the AngioVac [AngioDynamics] and Penumbra systems [Penumbra]). To our knowledge, the use of manual aspiration devices has not been reported yet. Here, we report the first case series on the use of the AlphaVac (AngioDynamics) (a large-bore manual aspiration device) system for left-sided intracardiac masses.


Examining The Internet Hunting Styles Of Violent Sexual Predators Who Rape And Murder Their Victims, Rebecca Meyers Dec 2024

Examining The Internet Hunting Styles Of Violent Sexual Predators Who Rape And Murder Their Victims, Rebecca Meyers

Walden Dissertations and Doctoral Studies

The proposed study sought to explore the impact of the internet on the hunting styles of sexual predators who sexually assault and kill their victims. A sample of 32 cases, divided equally among offenders who used the internet to target adult females and those who did not use the internet, was used for the study. The findings showed that various internet-based platforms were used for targeting, including dating apps such as Grindr, Match.com, Meetme.com, Tinder, Craigslist, Sex chat rooms, Kik Messenger, and BDSM sites. Three themes emerged about the impact of the internet on the hunting styles of sexual predators …


Exploring Kindergarten Teachers' Perspectives On The Interpretation Of Standards In A Developmentally Appropriate Way In Kindergarten Classrooms, Shawanza Demetrist Lockett Dec 2024

Exploring Kindergarten Teachers' Perspectives On The Interpretation Of Standards In A Developmentally Appropriate Way In Kindergarten Classrooms, Shawanza Demetrist Lockett

Walden Dissertations and Doctoral Studies

Many kindergarten teachers are feeling the effects of standard-based education. The problem is that it is unknown whether teachers implement mandated state standards in a developmentally appropriate way. The purpose of this basic qualitative study was to investigate kindergarten teachers’ perspectives on implementing standards in a developmentally appropriate manner. Shulman’s theory of teacher knowledge was the conceptual framework for the study. The research question focused on kindergarten teachers’ perspectives of implementing standards in a developmentally appropriate way. Twelve kindergarten teachers were recruited from three Title 1 elementary schools in a rural southeastern state in the United States. Thematic data analysis …


Strategies Small Business Leaders Use To Retain Employees To Reduce Turnover Costs, Karla Gilchrist-Saunders Dec 2024

Strategies Small Business Leaders Use To Retain Employees To Reduce Turnover Costs, Karla Gilchrist-Saunders

Walden Dissertations and Doctoral Studies

Failure to retain employees negatively affects organizational financial sustainability. Small business leaders become concerned when their organizations fail to retain employees, resulting in increased costs and decreased competitiveness, organizational knowledge, team dynamics, and valuable human resources. Grounded in transformational leadership theory, the purpose of this qualitative pragmatic inquiry study was to identify and explore leadership strategies some small business leaders use to retain employees to reduce turnover costs. The participants were six small business leaders in the Washington, DC, metropolitan area with successful strategies used to retain employees to reduce turnover costs. Data were collected from semistructured interviews and publicly …


The Psychological And Physical Impact Of The Opioid Crisis On Families, Adrienne Antoinette Hunter Wells Green Dec 2024

The Psychological And Physical Impact Of The Opioid Crisis On Families, Adrienne Antoinette Hunter Wells Green

Walden Dissertations and Doctoral Studies

Many rural areas in the United States have experienced an opioid crisis. Social support programs could be created to address social support for the families affected by opioid addiction. The purpose of this non-experimental, cross-sectional research study was to examine the possible relationship between (a) prescription or non-prescription addiction; (b) opioid addiction or another addiction; (c) the amount of family social support of a family member who has ongoing interactions with the individual struggling with addiction; and (d) stress of the family member in a rural area. Bowen’s family systems theory provided the theoretical framework for the study. A non-probability …


Leadership Strategies Indigenous Canadian Entrepreneurs Use To Sustain Their Business, Sherry Tyeesum Mattice Dec 2024

Leadership Strategies Indigenous Canadian Entrepreneurs Use To Sustain Their Business, Sherry Tyeesum Mattice

Walden Dissertations and Doctoral Studies

Indigenous Canadian small business entrepreneurs face a high risk of failure within five years of operation. These entrepreneurs encounter challenges such as limited access to capital and skilled employees and must develop strategies to sustain and grow their businesses. Grounded in the theory of constraints, the purpose of this qualitative multiple-case study was to explore strategies employed by Indigenous small business entrepreneurs to effectively sustain their businesses beyond 5 years. The participants were six Indigenous small business entrepreneurs in British Columbia who implemented strategies to sustain their businesses beyond 5 years. Data were collected through semistructured interviews and by reviewing …


Connections Between Household Socioeconomic Status, Modifiable Risk Factors, And Diabetes Status Among Adults In Jamaica, Sheriann Elizabeth Reid Dec 2024

Connections Between Household Socioeconomic Status, Modifiable Risk Factors, And Diabetes Status Among Adults In Jamaica, Sheriann Elizabeth Reid

Walden Dissertations and Doctoral Studies

Globally, diabetes is one of the most prevalent and challenging disorders. In Jamaica, the prevalence of the disease has increased by 42% since 2001. This study explored the connection between household socioeconomic status, modifiable risk factors, and diabetes status among adults in Jamaica using the social-ecological model. The study explored whether household socioeconomic status and modifiable risk factors were associated with diabetes and whether they predicted diabetes among Jamaican adults. A quantitative cross-sectional design was used to analyze data with 11,206 respondents from the Jamaica Survey of Living Conditions 2019 dataset. Binary logistic regression analysis revealed statistically significant associations between …


Utility Of Colposcopy For The Screening And Management Of Cervical Cancer In Africa: A Cross-Sectional Analysis Of Providers’ Training And Practices, Joël Fokom Domgue, Issimouha Dille, Freddy Gnangnon, Sharon Kapambwe, Celine Bouchard, Nomonde Mbatani, Elodie Gauroy, Nathalie Ledaga Ambounda, Robert Yu, Fatoumata Sidibe, Joseph Kamgno, Bangaly Traore, Pierre-Marie Tebeu, Gregory Halle-Ekane, Mohenou Isidore Diomande, Jean-Marie Dangou, Fabrice Lecuru, Isaac Adewole, Marie Plante, Partha Basu, Sanjay Shete Dec 2024

Utility Of Colposcopy For The Screening And Management Of Cervical Cancer In Africa: A Cross-Sectional Analysis Of Providers’ Training And Practices, Joël Fokom Domgue, Issimouha Dille, Freddy Gnangnon, Sharon Kapambwe, Celine Bouchard, Nomonde Mbatani, Elodie Gauroy, Nathalie Ledaga Ambounda, Robert Yu, Fatoumata Sidibe, Joseph Kamgno, Bangaly Traore, Pierre-Marie Tebeu, Gregory Halle-Ekane, Mohenou Isidore Diomande, Jean-Marie Dangou, Fabrice Lecuru, Isaac Adewole, Marie Plante, Partha Basu, Sanjay Shete

Faculty, Staff and Student Publications

Introduction: Cervical cancer is a public health issue in Africa with devastating socioeconomic consequences due to the lack of organized screening programs. The success of screening programs depends on the appropriate investigation and management of women who test positive for screening. Colposcopic assessment following positive screening results is a noteworthy issue in Africa. This study aimed to assess the utilization of colposcopy by providers in the region.

Methods: A cross-sectional study was conducted in 2021-2022 among healthcare providers involved in cervical cancer prevention activities in Africa. They were invited to report prior colposcopy training, whether they performed colposcopy and the …


Feasibility Of Large Language Models For Ceus Li-Rads Categorization Of Small Liver Nodules In Patients At Risk For Hepatocellular Carcinoma, Jiayan Huang, Rui Yang, Xiaotong Huang, Keyu Zeng, Yan Liu, Jun Luo, Andrej Lyshchik, Qiang Lu Dec 2024

Feasibility Of Large Language Models For Ceus Li-Rads Categorization Of Small Liver Nodules In Patients At Risk For Hepatocellular Carcinoma, Jiayan Huang, Rui Yang, Xiaotong Huang, Keyu Zeng, Yan Liu, Jun Luo, Andrej Lyshchik, Qiang Lu

Department of Radiology Faculty Papers

BACKGROUND: Large language models (LLMs) offer opportunities to enhance radiological applications, but their performance in handling complex tasks remains insufficiently investigated.

PURPOSE: To evaluate the performance of LLMs integrated with Contrast-enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) in diagnosing small (≤20mm) hepatocellular carcinoma (sHCC) in high-risk patients.

MATERIALS AND METHODS: From November 2014 to December 2023, high-risk HCC patients with untreated small (≤20mm) focal liver lesions (sFLLs), were included in this retrospective study. ChatGPT-4.0, ChatGPT-4o, ChatGPT-4o mini, and Google Gemini were integrated with imaging features from structured CEUS LI-RADS reports to assess their diagnostic performance for sHCC. …


Influenza Knowledge And Barriers To Vaccination In Immunosuppressed Patients In The Pediatric Rheumatology Clinic., Julia G. Harris, Leslie Favier, Jordan T. Jones, Maria Ibarra, Michael J. Holland, Emily Fox, Kelly Jensen, Ashley K. Sherman, Ashley M. Cooper Dec 2024

Influenza Knowledge And Barriers To Vaccination In Immunosuppressed Patients In The Pediatric Rheumatology Clinic., Julia G. Harris, Leslie Favier, Jordan T. Jones, Maria Ibarra, Michael J. Holland, Emily Fox, Kelly Jensen, Ashley K. Sherman, Ashley M. Cooper

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Most patients with a pediatric rheumatic disease are at increased risk of influenza due to immunosuppressive medication use. Despite initial quality improvement efforts, our influenza vaccination rate plateaued at 72%, which prompted a survey of patients and families to assess provider vaccine recommendations, influenza knowledge, and barriers to influenza vaccination.

METHODS: Patients on immunosuppressive medication or their parent were eligible to complete a survey between July 2019 and January 2020. Survey questions assessed demographics, rheumatology diagnosis, immunosuppressive medication(s), influenza vaccination recommendation, patient/parent influenza knowledge, and barriers to influenza vaccination. Influenza vaccination rates for immunosuppressed patients were acquired each influenza …


Structural Variant Allelic Heterogeneity In Mecp2 Duplication Syndrome Provides Insight Into Clinical Severity And Variability Of Disease Expression., Davut Pehlivan, Jesse D. Bengtsson, Sameer S. Bajikar, Christopher M. Grochowski, Ming Yin Lun, Mira Gandhi, Angad Jolly, Alexander J. Trostle, Holly K. Harris, Bernhard Suter, Sukru Aras, Melissa B. Ramocki, Haowei Du, Michele G. Mehaffey, Kyunghee Park, Ellen Wilkey, Cemal Karakas, Jesper J. Eisfeldt, Maria Pettersson, Lynn Liu, Marwan S. Shinawi, Virginia E. Kimonis, Wojciech Wiszniewski, Kyle Mckenzie, Timo Roser, Angela M. Vianna-Morgante, Alberto S. Cornier, Ahmed Abdelmoity, James P. Hwang, Shalini N. Jhangiani, Donna M. Muzny, Tadahiro Mitani, Kazuhiro Muramatsu, Shin Nabatame, Daniel G. Glaze, Jawid M. Fatih, Richard A. Gibbs, Zhandong Liu, Anna Lindstrand, Fritz J. Sedlazeck, James R. Lupski, Huda Y. Zoghbi, Claudia M B Carvalho Dec 2024

Structural Variant Allelic Heterogeneity In Mecp2 Duplication Syndrome Provides Insight Into Clinical Severity And Variability Of Disease Expression., Davut Pehlivan, Jesse D. Bengtsson, Sameer S. Bajikar, Christopher M. Grochowski, Ming Yin Lun, Mira Gandhi, Angad Jolly, Alexander J. Trostle, Holly K. Harris, Bernhard Suter, Sukru Aras, Melissa B. Ramocki, Haowei Du, Michele G. Mehaffey, Kyunghee Park, Ellen Wilkey, Cemal Karakas, Jesper J. Eisfeldt, Maria Pettersson, Lynn Liu, Marwan S. Shinawi, Virginia E. Kimonis, Wojciech Wiszniewski, Kyle Mckenzie, Timo Roser, Angela M. Vianna-Morgante, Alberto S. Cornier, Ahmed Abdelmoity, James P. Hwang, Shalini N. Jhangiani, Donna M. Muzny, Tadahiro Mitani, Kazuhiro Muramatsu, Shin Nabatame, Daniel G. Glaze, Jawid M. Fatih, Richard A. Gibbs, Zhandong Liu, Anna Lindstrand, Fritz J. Sedlazeck, James R. Lupski, Huda Y. Zoghbi, Claudia M B Carvalho

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: MECP2 Duplication Syndrome, also known as X-linked intellectual developmental disorder Lubs type (MRXSL; MIM: 300260), is a neurodevelopmental disorder caused by copy number gains spanning MECP2. Despite varying genomic rearrangement structures, including duplications and triplications, and a wide range of duplication sizes, no clear correlation exists between DNA rearrangement and clinical features. We had previously demonstrated that up to 38% of MRXSL families are characterized by complex genomic rearrangements (CGRs) of intermediate complexity (2 ≤ copy number variant breakpoints < 5), yet the impact of these genomic structures on regulation of gene expression and phenotypic manifestations have not been investigated.

METHODS: To study the role of the genomic rearrangement structures on an individual's clinical phenotypic variability, we employed a comprehensive …


Embolic Stroke In A Patient With Left Atrial Myxoma, Muhammad Sabri, Sheraz Qamar, Naila Ijaz, Mark Decaro Dec 2024

Embolic Stroke In A Patient With Left Atrial Myxoma, Muhammad Sabri, Sheraz Qamar, Naila Ijaz, Mark Decaro

Division of Cardiology Faculty Papers

We present a case of a patient with a left atrial myxoma who presented with an ischemic stroke. Her cardiac myxoma had an irregular contour and was highly mobile, both features that have been associated with a greater risk of thrombo- embolism. She was treated with prompt surgical resection


Functional Properties Of Corticothalamic Circuits Targeting Paraventricular Thalamic Neurons, Guillermo Aquino-Miranda, Dounya Jalloul, Xu O Zhang, Sa Li, Gilbert J Kirouac, Michael Beierlein, Fabricio H Do Monte Dec 2024

Functional Properties Of Corticothalamic Circuits Targeting Paraventricular Thalamic Neurons, Guillermo Aquino-Miranda, Dounya Jalloul, Xu O Zhang, Sa Li, Gilbert J Kirouac, Michael Beierlein, Fabricio H Do Monte

Faculty, Staff and Student Publications

Corticothalamic projections to sensorimotor thalamic nuclei show modest firing rates and serve to modulate the activity of thalamic relay neurons. By contrast, here we find that high-order corticothalamic projections from the prelimbic (PL) cortex to the anterior paraventricular thalamic nucleus (aPVT) maintain high-frequency activity and evoke strong synaptic excitation of aPVT neurons in rats. In a significant fraction of aPVT cells, such high-frequency excitation of PL-aPVT projections leads to a rapid decay of action potential amplitudes, followed by a depolarization block (DB) that strongly limits aPVT maximum firing rates, thereby regulating both defensive and appetitive behaviors in a frequency-dependent manner. …