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The Ethical Requirements To Avoid Clinical Error Via Safety, Augustus Nweze, Augustus Ifeanyi Nweze Fr

Electronic Theses and Dissertations

Establishing safety programs across healthcare organizations will help to eliminate clinical errors and promote patient safety goals such as culture of quality and safety. Following the 1999 IOM Report, To Err is Human: Building a Safer Health System, regarding the high rate of injuries and deaths due to medical errors, healthcare institutions and policymakers at all levels have continued to draw attention to patient safety programs. As a result, patient safety programs have been implemented nationally to avoid clinical error in healthcare. Regulatory agencies like The Joint Commission, which oversees the voluntary accreditation of hospitals in the U.S. continues to …

Investigating Anomalous Experiences In Schizophrenia Spectrum Disorders, Pavan Brar

Electronic Theses and Dissertations

The self-disorder model provides a phenomenological framework for understanding how the core symptoms of Schizophrenia Spectrum Disorders (SSDs) are rooted in an instability of minimal selfhood. This instability involves a range of ‘anomalous experiences’: transformations in an individual’s perceptual field and sense of being an agent of action. The explanatory value of this theoretical model can be summarized in two claims about the role of anomalous experiences in self-disorders: (1) anomalous experiences express a common trait-like disturbance that is characteristic of SSDs, and (2) anomalous experiences contribute to the progression of self-disorders into SSDs. Although hypotheses consistent with the first …

The Ethical Contributions Of Nudges To Healthcare, Ian Doherty

Electronic Theses and Dissertations

“The Ethical Contributions of Nudges to Healthcare” examines the ethical use, implications, and rationale for using nudges in healthcare. The use of nudges in healthcare are being empirically examined. This leaves much to be examined from the ethical perspective. To examine the ethical perspective, the dissertation lays out how nudges interact with and enhance the biomedical principles of autonomy and beneficence. The dissertation then turns to clinical ethics. Nudges, more specifically the framing effect, are paired with trust in the patient-physician relationship to discern how best to aid a patient in his or her medical decision-making. The dissertation then investigates …

The Ethics Of Involuntary Psychiatric Hospitalization: A Comprehensive Analysis Of Policies, Practice, And Ethical Oversight, Mariah Chobany

Electronic Theses and Dissertations

As a specialized field of medicine, psychiatry presents unique ethical challenges and dilemmas distinct from other medical disciplines. A particularly complex aspect of psychiatric care involves the involuntary treatment of patients who may be unable to make informed decisions about their care or participation in research due to the debilitating effects of their psychiatric condition. This presents a significant challenge for providers and researchers, particularly concerning capacity issues and the informed consent process. Despite the intricacies and complexities of ethical dilemmas in psychiatric treatment and research, there is a notable lack of comprehensive guidance in policies and practices on addressing …

The Influence Of Social Media On Adolescent Mental Health, Sally Diomande

Psychology Student Publications

This paper goes through the difficult relationship between social media use and adolescent mental health, focusing on both the positive and negative impacts. It discusses how social comparison, amplified by social media, can lead to feelings of inadequacy, anxiety, and depression, particularly due to the idealized representations of others lives.The paper also highlights the dangers of cyber-bullying, which exacerbates mental health issues and even leads to suicidal thoughts in some adolescents.

Diagnosing And Treating Adhd In Children, Ellie Renner

Psychology Student Publications

The goal of this paper is to raise awareness for the diagnosis and treatment of ADHD in children. ADHD stands for attention deficit hyperactivity disorder. As a parent, when you have reason to believe your child has ADHD, or they were diagnosed with ADHD, it is important to learn more about the diagnosis and the options for treating your child’s ADHD. This paper will provide you with information to help navigate the diagnosis.

Fsec Meeting Minutes December 20, 2024, University Of Rhode Island Faculty Senate

Faculty Senate Executive Committee Minutes

No abstract provided.

Body Study, Annaliese "Ace" Taylor

Theses

A paper chronicling the creation of my graduate thesis film, Body Study.

Toward Prototypical Vision Clustering, James Chenhao Liang

Theses

Over the past decades, deep learning methods have emerged as the predominant approach in computer vision. Most approaches rely on complex interactions among pixels, involving heavy computations. However, Human vision possesses a unique attention mechanism that selectively focuses on relevant parts of the visual field while disregarding irrelevant information. This can be likened to a clustering approach, in which individual pixel points are decomposed and reorganized into relevant concepts to address various tasks. This dissertation explores the frontier of vision clustering by integrating innovative prototypical learning with advanced Transformer architectures, which heralds a significant paradigm shift applied to vision clustering. …

Administrators

Catholic University Law Review

No abstract provided.

If It Was Good Enough To Work Against The Nazis . . . : Revitalizing The Foreign Agents Registration Act To Regulate Modern Foreign Electioneering, Troy Mccurry

Catholic University Law Review

News headlines from the 2016 election to the present have described an ongoing political scandal that is unmatched in modern history: continued attempts of foreign interference in U.S. elections. It is fairly obvious that the United States lacks adequate restrictions to prevent foreign interference in U.S. elections. It therefore needs a law that—while passing constitutional scrutiny—prohibits more foreign political activity than what is currently covered, especially in relation to social media. This should be a simple and effective legislative fix, a return to the core aspects of the original Foreign Agents Registration Act (FARA) that focuses on potential electioneering of …

Novel Digital Anomalies, Hippocampal Atrophy, And Mutations Expand The Genotypic And Phenotypic Spectra Of Cnksr2 In The Houge Type Of X-Linked Syndromic Intellectual Development Disorder (Mrxshg), Mohammad Reza Ghasemi, Sahand Tehrani Fateh, Afif Ben-Mahmoud, Vijay Gupta, Lara G. Stühn, Gaetan Lesca, Nicolas Chatron, Konrad Platzer, Patrick Edery, Hossein Sadeghi, Bertrand Isidor, Benjamin Cogné, Heidi L. Schulz, Ilona Krauspe-Stübecke, Radhakrishnan Periyasamy, Sheela Nampoothiri, Reza Mirfakhraie, Sahar Alijanpour, Steffen Syrbe, Ulrich Pfeifer, Stephanie Spranger, Kathrin Grundmann-Hauser, Tobias B. Haack, Maria T. Papadopoulou, Tayrine Da Silva Gonçalves, Eleni Panagiotakaki, Alexis Arzimanoglou, Seyed Hassan Tonekaboni, Yves Lacassie, Et Al

School of Medicine Faculty Publications

The Houge type of X-linked syndromic intellectual developmental disorder (MRXSHG) encompasses a spectrum of neurodevelopmental disorders characterized by intellectual disability (ID), language/speech delay, attention issues, and epilepsy. These conditions arise from hemizygous or heterozygous deletions, along with point mutations, affecting CNKSR2, a gene located at Xp22.12. CNKSR2, also known as CNK2 or MAGUIN, functions as a synaptic scaffolding molecule within the neuronal postsynaptic density (PSD) of the central nervous system. It acts as a link connecting postsynaptic structural proteins, such as PSD95 and S-SCAM, by employing multiple functional domains crucial for synaptic signaling and protein–protein interactions. Predominantly expressed in dendrites, …

Glucagon-Like Peptide-1 Receptor Agonist Mediated Weight Loss And Diabetes Mellitus Benefits: A Narrative Review, Alan D. Kaye, Nathan Lien, Christopher Vuong, Matthew H. Schmitt, Yusra Soorya, Bushirat A. Abubakar, Luke Muiznieks, Noah Embry, Harish Siddaiah, Adam M. Kaye, Sahar Shekoohi, Giustino Varrassi

School of Medicine Faculty Publications

Obesity and type 2 diabetes mellitus (T2DM) are chronic diseases with increasing prevalence, underscoring the urgent need for effective treatment and management strategies. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as an essential class of drugs for managing both obesity and T2DM, offering additional benefits for cardiovascular and kidney health. GLP-1 RAs work by targeting GLP-1 receptors, mimicking the effects of the natural hormone GLP-1 to regulate blood glucose levels, promote weight loss, and provide potential benefits for cardiovascular health. This narrative review evaluates the mechanisms of action, clinical efficacy, and broader roles of GLP-1 RAs in promoting weight …

Influence Of Antibody–Drug Conjugate Cleavability, Drug-To-Antibody Ratio, And Free Payload Concentration On Systemic Toxicities: A Systematic Review And Meta-Analysis, Shou Ching Tang, Carrie Wynn, Tran Le, Martin Mccandless, Yunxi Zhang, Ritesh Patel, Nita Maihle, William Hillegass

School of Medicine Faculty Publications

While in theory antibody drug conjugates (ADCs) deliver high-dose chemotherapy directly to target cells, numerous side effects are observed in clinical practice. We sought to determine the effect of linker design (cleavable versus non-cleavable), drug-to-antibody ratio (DAR), and free payload concentration on systemic toxicity. Two systematic reviews were performed via PubMed search of clinical trials published between January 1998—July 2022. Eligible studies: (1) clinical trial for cancer therapy in adults, (2) ≥ 1 study arm included a single-agent ADC, (3) ADC used was commercially available/FDA-approved. Data was extracted and pooled using generalized linear mixed effects logistic models. 40 clinical trials …

Defining The Chondrocyte “Mechanome”: How Mechanosensitive Ion Channels Trpv4 And Piezo1 Drive Changes In Gene Expression To Affect Cell Behavior And Cartilage Health, Daniel Raymond Palmer

McKelvey School of Engineering Graduate Student Theses & Dissertations

Chondrocytes, the only native cell population of cartilage, utilize mechanosensitive transmembrane ion channels to sense mechanical forces. Transient Receptor Potential Vanilloid 4 (TRPV4) is activated by physiologic levels of load (resulting in ~10% tissue deformation) while PIEZO1 is activated by supraphysiologic levels of load (resulting in >50% tissue deformation). TRPV4 activation promotes the expression of a limited number of chondrogenic genes and the production of vital cartilaginous matrix proteins, while PIEZO1 activation drives cell death and senescence, cytoskeletal weakening, and production of catabolic mediators, which contribute to the development of osteoarthritis (OA). However, the path connecting activation of these channels …

Bone-Ivd Crosstalk And The Role Of Rage Signaling In An Ivd Injury Model, Remy Walk

McKelvey School of Engineering Graduate Student Theses & Dissertations

Low back pain (LBP) is the number one musculoskeletal cause of disability with a lifetime prevalence of up to 85%. The causes of LBP are multifactorial with potential contributions from factors such as tissue injury and degeneration as well as social economic and psychological factors. Intervertebral disc (IVD) degeneration is associated with 26-40% of LBP cases and in a 2015 meta-analysis, it was estimated that a total 403 million people suffer from symptomatic IVD degeneration. IVD degeneration is characterized by loss of hydration in the nucleus pulposus (NP), damage accumulation in the annulus fibrosus (AF) and calcification of the cartilaginous …

Developing Naturalistic Precision Functional Mapping For High-Density Diffuse Optical Tomography, Aahana Bajracharya

McKelvey School of Engineering Graduate Student Theses & Dissertations

Advancements in non-invasive imaging have enabled extensive research into higher-order cognitive functions of the brain. Functional Magnetic Resonance Imaging (fMRI) has provided valuable insights into brain networks underlying various cognitive processes. However, limitations such as confined environments and scanner noise pose challenges for fMRI to be broadly applicable across all demographics and experimental conditions, especially in speech and language studies. Because of this, there is a need for complementary techniques that can help understand the brain as it functions during everyday scenarios. High Density Diffuse Optical Tomography (HD-DOT) is an emerging functional near-infrared spectroscopy-based technique with comparative advantages over fMRI, …

Integrating Physics And Deep Learning For Transmission-Less Attenuation Compensation In Clinical Spect, Zitong Yu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Attenuation compensation (AC) is beneficial for visual interpretation and serves as a prerequisite for quantification tasks in single-photon emission computed tomography (SPECT) imaging. However, conventional AC methods typically rely on a separate X-ray CT component, leading to multiple challenges. In this context, studies have shown that scatter-window projection data contains information to estimate the attenuation distribution. Furthermore, large amounts of SPECT emission data in both photopeak and scatter-energy windows and corresponding CT scans are available. The ability of deep learning (DL) to model complex relationships by leveraging large datasets motivates its use for transmission-less AC in SPECT. Building upon the …

Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The discrete element method (DEM) is a widely used numerical approach for simulating and analyzing the behavior of granular materials in various applications. This research focuses on the iron ore beneficiation process, addressing the clumping issue in cohesive iron ores from existing crushing processes through a novel double-layered disperser design. The significance of this study lies in its potential to enhance the efficiency of the existing crushing phase and improve the linkage to subsequent purification stages that target smaller-sized iron ore pellets, thereby enhancing the overall efficiency of the ore beneficiation process and achieving significant energy savings. This research adopts …

Statins Decrease The Risk Of Hepatocellular Carcinoma In Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review And Meta-Analysis, Zahid Ijaz Tarar, Umer Farooq, Faisal Inayat, Sanket D. Basida, Faisal Ibrahim, Mustafa Gandhi, Gul Nawaz, Arslan Afzal, Ammad J. Chaudhary, Faisal Kamal, Ahmad H. Ali, Yezaz A. Ghouri

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease with a significant risk of developing hepatocellular carcinoma (HCC). Recent clinical evidence indicates the potential benefits of statins in cancer chemoprevention and therapeutics. However, it is still unclear if these drugs can lower the specific risk of HCC among patients with MASLD.

AIM: To investigate the impact of statin use on the risk of HCC development in patients with MASLD.

METHODS: A systematic review and meta-analysis of all the studies was performed that measured the effect of statin use on HCC occurrence in patients with …

An Intelligent System Using Deep Learning For Healthcare Monitoring In Light Of The Covid-19 And Future Pandemics Based On Iot, Sara Salman Qasim, Rajaa J. Khanjar, Jamal Nasir Hasoon, Baesher Abdullateff Abad, Ali Hussein Fadil, Shajan.M. Alsowaidi

Al-Esraa University College Journal for Engineering Sciences

Recently, the Internet of Things has become a compelling research field as a new topic of research in various disciplines, particularly in the field of healthcare, because the Internet of Things is rebuilding modern healthcare systems by integrating technology, economics, and social perspectives. The development of healthcare systems from traditional to more personalized systems in which patients can be easily diagnosed, monitored and treated and many people can be helped. People are treated and cared for remotely and this is what some people need in the crisis the world has been through like COVID-19. This epidemic is caused by the …

Speech Coding Based On A Hybrid Approach: Dct, Huffman And Run-Length Coding, Sundos Abdulameer Alazawi, Esraa Jaffar Baker, Shahbaa Mohammed Abdulmaged

Al-Esraa University College Journal for Engineering Sciences

The exponential expansion of data in the digital world necessitates the development of effective methods for data transmission and storage. Data compression (DC) strategies are suggested to reduce the quantity of data stored or conveyed due to constrained resources. As a result of DC ideas' ability to efficiently use existing storage space and transmission capacity, different methods have been developed in various areas. Speech coding is a lossy method of coding; therefore, the output signal differs slightly from the input signal. Speech coding is useful for message encryption, communication over long distances and speech quality. In the fields of digital …

Predictors Of Sedimentary Organic Carbon In Seagrass Vegetated And Unvegetated Sediment In The Tamar Estuary, United Kingdom, Kathryn Pogson

The Plymouth Student Scientist

Seagrass meadows are considered significant natural carbon sinks due to their ability to store large amounts of organic carbon (C_org) in their sediments. ‘Blue carbon strategies’ aim to utilise and enhance this ability to mitigate climate change. However, assessing the C_org content and the habitat characteristics that influence this, in both seagrass vegetated and adjacent unvegetated sediments is needed to improve ‘Blue Carbon’ assessments. Currently, adjacent unvegetated sediments are excluded from Blue Carbon assessments as investigations rarely incorporate them into study design, despite evidence suggesting that they can also store significant amounts of C_org. Mean …

An In-Depth Analysis And Comparison Of Eco And Non-Eco Surfboard Waxes, Markos Kaskaneas - Efthymiou

The Plymouth Student Scientist

Questions regarding the sustainability of petroleum-based surfboard waxes gave rise to the development and marketing of a sustainable alternative called “Eco” surf wax. The chemistry behind surf waxes is generally unknown and there is no published research on the area of surf waxes. In this analysis, the chemical properties of both types of waxes were investigated, to determine the difference between non-eco and eco waxes and between different water temperature rating waxes. 15 surf wax samples (10 non-eco, 5 eco) were extracted into organic and inorganic fractions and analysed by FT-IR, GC-MS, and HTGC-FID/MS. Multivariate statistical analysis was also performed. …

Assessing The Factors That Contribute To Marine Protected Area (Mpa) Effectiveness And Whether Global Protected Areas Of 30% Can Be Achieved By 2030, Jil L. Heinimann

The Plymouth Student Scientist

The urgency for effective conservation to mitigate the rapid deterioration of our marine habitats, which provide ecological, social, and economic benefits, is widely recognised. Marine Protected Areas (MPAs) have emerged as a pivotal tool in marine conservation. However, global MPA performance varies, and employed management schemes differ. This report aims to investigate the factors which contribute to MPA effectiveness, therefore success, and assess the feasibility of achieving the global target to conserve 30% of habitats by 2030; outlined in the Kunming-Montreal Global Biodiversity Framework (GBF, Target 3). To achieve this, a systematic literature review was conducted, employing search-strings, inclusion/exclusion criteria, …

Developing A Method To Identify Tyre Particles By Detecting Benzothiazole Via Gc-Ms, Emma Paull

The Plymouth Student Scientist

Tyre particles are a dominant source of microplastic pollution in our environment. However, their chemical and physical properties are poorly understood and no standardised methods for identifying and quantifying them exist. This study looked to develop a method to identify tyre particles using two tyre samples of differing particle sizes, fine (62 - 125 µm) and coarse (250 – 500 µm). Both samples underwent ultrasound-assisted extraction before being analysed via gas chromatography-mass spectrometry (GC-MS) in both full scan and SIM mode, using benzothiazole as a marker. Both samples were also analysed via particle size analysis, scanning electron microscopy (SEM) and …

An Investigation Into The Current Knowledge And Consumption Frequencies Of Probiotic Products Amongst Uk-Based Athletes, Ella J. Myers

The Plymouth Student Scientist

Growing evidence supports the role of probiotics as modulators of the gut microbiome and subsequent beneficial effects on health, adaptations to exercise, and performance amongst athletes. Despite this, limited literature exists concerning athletes’ current understanding or consumption habits of such products. Therefore, the present study aimed to investigate the knowledge and consumption frequencies of probiotic products amongst UK-based recreational and competitive athletes using a three-part online questionnaire. A scoring system based on the number of correct responses to questions regarding probiotics was employed to assess athlete knowledge. Subsequent questions allowed for the collection of data regarding respondents’ current consumption habits …

The Impact Of Artificial Light At Night On The Distribution Of Sea Turtles In The Mediterranean, Molly R. Blyth

The Plymouth Student Scientist

Artificial light at night (ALAN) poses a significant threat to a wide array of species across the world. In coastal areas, artificial lighting is known to disrupt sea-finding behaviour of sea turtle hatchlings and to deter females from nesting beaches. Yet, sea turtles spend the majority of their lifetimes in the sea, where the influence of ALAN on sea turtle distribution has not previously been studied. Using a recently published atlas of ALAN under the sea, this study analysed an online dataset of sea turtle sightings throughout the Mediterranean Sea, to look for a relationship using a binomial generalised linear …

The Weight Of Words: An Investigation On The Impact Of Stereotypical Body Language On Body Dissatisfaction, Hannah M. Brown

The Plymouth Student Scientist

Body image research is extensive, producing various tools to assess body dissatisfaction and related factors. Despite this, eating disorder rates remain high. This study investigates the relationship between self-schemas, the lexical frameworks of body-related words, and their impact on body shape dissatisfaction. Sociocultural pressures to conform to beauty standards make body image talk ubiquitous and influential. Previous studies primarily used explicit measures, like self-reports, which are subject to biases, whereas implicit measures reveal underlying cognitive mechanisms. This study employed the Stunkard Figure Scale to measure body dissatisfaction and the Body Appreciation Scale 2 to assess body appreciation, examining cognitive biases …

Measurement Of The Mechanical Properties Of Blood Vessels Using A Vascular Simulation Rig, Jack Lockyer

The Plymouth Student Scientist

Understanding the mechanical properties of blood vessels is crucial for reconstructive surgeons who connect donor tissue flaps to recipient sites. This paper describes the development of a vascular simulation test rig that delivers pulsatile flow to a blood vessel sample while continuously monitoring system pressure and sample diameter. These measurements allow for the calculation of the viscous coefficient, an important mechanical property for comparing blood vessels. A pilot test using the rig demonstrates its ability to measure pressure and diameter and highlights necessary improvements to enhance data quality. The pilot test shows that the current rig can measure 5 mm …