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Ethical Considerations In The Diagnosis And Treatment Of Autism Spectrum Disorder, Ferdinand Okafor

Electronic Theses and Dissertations

This dissertation is an ethical response to the ethical issues in the assessment, diagnosis, and treatment of autism. The problems that underlie the discussion are misconception about autism and Autistics. The misconception about autism and Autistics lead to misinterpretation of the neurological functioning, cognition, and the behaviors of Autistics. Consequently, it influences the approach and model of care in the assessment, diagnosis, and treatment of autism. Currently, the analytic approach and biomedical model of disease are applied in the assessment, diagnosis, and treatment of autism. The motive of the analytic approach and biomedical care is to cure autism. The consequence …

Development Of Methods For Predicting Second Harmonic Generation (Shg) Responses Of New Infrared Nonlinear Optical (Ir-Nlo) Materials, Katherine Colbaugh

Electronic Theses and Dissertations

Dissertation supervised by Dr. Jennifer A. Aitken.

In this work, calculations-based methods were evaluated for use in prediction of second harmonic generation (SHG), specifically χ⁽²⁾ values, of infrared nonlinear optical (IR-NLO) materials. Net dipole moment and dipole moment per volume were calculated by the bond valence sum method. Average F-index, proposed in this research, and group F-index, both representing induced dipole moment were also calculated. Each calculation was evaluated by comparing the results to single crystal and powder χ⁽²⁾ measurements of IR-NLO materials. The selected dataset consisted of ninety-six compounds including polar and nonpolar structures, newly discovered and …

Rna Structural-Dynamical Hierarchy: Sars-Cov, Sars-Cov-2, And Delta/Omicron Variant S2m Monomers, Kissing Complexes, And Extended Duplexes, Adam Kensinger

Electronic Theses and Dissertations

The power and promise of ribonucleic acid (RNA) molecules are only beginning to be realized in living organisms and pharmaceutical intervention. Specifically, defining the chemical physics of RNA’s heterogenous structural ensemble and dynamics, which has experienced expansive growth over the last few years, is central to a complete understanding, yet continues to be a significant challenge. A 41-nucleotide hairpin called the stem-loop II motif (s2m), present in the viral genomes of severe acute respiratory syndrome (SARS), SARS-coronavirus-2 (SARS-CoV-2), and the Delta and Omicron variants responsible for the COVID-19 pandemic, is a potential antiviral target due to its high sequence conservation …

Saudi And American Students’ Motivation And Anxiety In Online Collaborative Learning In The United States, Nawal Alqarni

Electronic Theses and Dissertations

This research study aims to explore motivation and anxiety Saudi and American students in online collaborative learning environments through online courses in U.S. universities and how they relate to their academic performance.

The study utilized a quantitative approach for data collection through an online survey of 99 Saudi students and 39 American students who were enrolled in U.S. universities. The results showed that there was no significant difference in motivation scores between undergraduate Saudi students and their American counterparts. Nor was a significant difference observed in motivation scores between graduate Saudi students and graduate American students. The data also indicated …

Efficient Development Of Density-Insensitive Near-Infrared Methods For In-Line Drug Content Monitoring In Continuous Powder Streams, Natasha L. Velez-Silva

Electronic Theses and Dissertations

A well-defined action plan to respond effectively to sudden changes in product demand is critical for preventing drug shortages within the pharmaceutical industry. An effective way to increase the output of a continuous manufacturing (CM) process is through flow rate adjustments. However, robust analytical methods must be in place to ensure consistent analytical performance across varying flow rates. Existing approaches for mitigating the physical effects of flow rate on Near-Infrared (NIR) measurements are often burdensome. Thus, efficient robust modeling strategies that reduce the current calibration burden and ensure model insensitivity to the physical variations in CM systems are needed. In …

Muslim Spirituality As A Foundation In Bioethics For Patient Encounters In Health Care, Sara Rahman

Electronic Theses and Dissertations

Spirituality plays a major role in decision making for individuals with faith-based values. There is often hesitation to discuss the role of faith in healthcare as a core value and coping mechanism. The growing cultural diversity amongst patients and physicians has increased the need to understand eastern religious principles and incorporate them into bioethical guidance. Even as the 2nd largest religion in the world, Islam has not been sufficiently integrated into religious bioethics in western medicine. Muslim populations of patients and physicians are growing, increasing the need for better understanding of how Islamic principles impact healthcare delivery. Although Islamic law …

Design, Synthesis, And Characterization Of Multi-Targeting Pyrrolopyrimidine Antifolates As Potential Single Agent Chemotherapeutic Entities, Tejashree Magdum

Electronic Theses and Dissertations

In cancer chemotherapy, the currently marketed antifolates have two major disadvantages: dose-limiting toxicities to normal tissues and susceptibility to drug resistance. These are due to their major transport by the ubiquitously expressed transporter and mutagenesis in enzymes present in cancer cells. This thesis describes an introduction, background, and research progress in antimetabolites-antifolates designed to multi-target (a) one-carbon metabolism and de novo nucleotide synthesis pathway and (b) target overexpressed transporter in cancer cells for selective tumor-targeting.

Cancer cells transport folate through three transporters: ubiquitously expressed reduced folate carrier (RFC), limitedly expressed proton-coupled folate transporter (PCFT), and folate receptors (FRs). The research …

Staff Council Minutes, Georgia Southern University

Staff Council Meeting Minutes & Agendas

No abstract provided.

Staff Council Agenda, Georgia Southern University

Staff Council Meeting Minutes & Agendas

No abstract provided.

Daily Associations Between Minority Stressors And Dissociation For Sexual Minority Women And Transgender/Nonbinary Individuals: The Role Of Interpersonal Trauma, Kriti Behari

Theses - ALL

Sexual minority women (SMW), transgender, and/or gender-diverse (TGD) individuals experience interpersonal traumatic stressors (e.g., childhood abuse, sexual violence) at higher rates than their cisgender, heterosexual counterparts. This population also experiences ongoing stressors related to their minoritized sexual and gender identities (e.g., stigma, discrimination). Dissociation has been positively associated with trauma exposure-related factors (e.g., trauma type, chronicity, and severity) as well as identity-related stressors (e.g., stigma, discrimination) for sexual and gender minority people. Some research suggests that experiencing dissociation in response to traumatic stressors can result in individuals responding to non-traumatic chronic stressors with dissociation. However, no study has yet examined …

Tanzania Petroleum Development Corporation (Tpdc) And Its Role In Self-Reliance And Sustainability, Ladislaus Norbeth Tumbu

Theses - ALL

Tanzania possesses significant natural gas reserves, currently estimated at 57.54 trillion cubic feet, with the potential for further discoveries. This thesis examines the socio-economic impacts of Tanzania’s substantial natural gas reserves, focusing specifically on the Tanzania Petroleum Development Corporation (TPDC) and its engagement with the local communities in Mtwara and Lindi. TPDC is the national oil company and owner of all licenses for energy development in the country, wholly owned by the government of Tanzania with all its shares held by the Treasury Registrar. Through comprehensive literature review and field visits to production sites, the study examines TPDC’s management of …

Examining The Dynamic Nature Of Acceptability In A Performance Feedback Writing Intervention, Tyler J. Young

Theses - ALL

Acceptability, or the perception that an intervention is appropriate, fair, and reasonable, is a critical construct to assess when implementing interventions (Kazdin, 1981). Despite original conceptualizations of acceptability as dynamic, or changing throughout intervention implementation (Foster & Mash, 1999; Schwartz & Baer, 1991), repeated acceptability assessments have been conducted up to only 9.26% of the time in intervention research (Silva et al., 2019). Studies that have previously conducted repeated assessments did not descriptively report or analyze differences in acceptability across sessions (e.g., DuBois et al., 2016; Raggi et al., 2009). No study to date has conducted dynamic assessments of acceptability …

Symposium On Leadership Competencies For Peace Leadership: An Overview And Invitation, Whitney Mcintyre Miller

Education Faculty Articles and Research

"This Symposium proposes eight leadership competencies, presented by experts in each area, as examples of ways in which leadership can be aligned with peace in order to bring about sustainable, positive change. This Symposium does not argue for just another list of leadership skills and practices, but rather, illustrates that when leadership competencies are intentionally combined with peace practices, we can engage in the work of peace leadership: leading our communities, organizations, and societies toward peace and equitable justice. Therefore, this Symposium utilizes these competencies as a “jumping off point” to nudge the field of leadership studies to begin to …

“Baking Inclusion Into Everything”: Internal Communication And Black And Latina Women’S Stories Of Intersectionality, Natalie Martell-Concepcion

Student Theses and Dissertations

Internal communications play a major role in creating diverse and inclusive workplace cultures. This study explores the lived experiences of Black and Latina women who work in internal communications, offering unique insights into how their identities intersect with workplace culture and strategic communication. Through a qualitative approach, six intersectional women, three Black and three Latina, were interviewed to examine how gender, racial and ethnic identities influence their work experiences and contributions. The results indicate that while Black and Latina women are treated differently at work compared to other groups, they use their differences to positively contribute to their companies’ internal …

Assembly Of Ppsu-Oligomers, Mariam Nesterov

Student Theses and Dissertations

The development of nanostructures for delivering multiple proteins to targeted antibodies has become a promising avenue in biotechnology, driven by advancements in synthetic polymers like poly(propylene sulfone), PPSU. However, the PPSU polymer faces a major limitation - its high insolubility. To address this challenge, this study investigates whether PPSU oligomers can enhance both the solubility and stability of lysozyme, a model protein that is cost-effective and widely accessible. Using dimer, trimer, tetramer, and hexamer configurations, we analyzed the interactions between PPSU oligomer and lysozyme under varying conditions. Our results show that the dimer and trimer are water soluble (no aggregate …

When Do States Outsource Repression: Evidence From Hong Kong, Ming Kong

Student Theses and Dissertations

What explains the variation in states using state versus nonstate actors in responding to civil unrest? Prior research on state repression has predominantly focused on the direct use of force by state authorities, often neglecting the critical role of third parties, such as organized crime groups, in executing repression. This practice, known as "outsourcing repression", enables states to maintain control while preserving plausible deniability, particularly in contexts requiring substantial coercion. This study aims to elucidate the conditions under which states opt to outsource repression. I propose a two-step logical framework. First, I argue that outsourcing repression depends on the availability …

The Search For Unenumerated Fundamental Rights, Alina Sluzhyvenkova

Student Theses and Dissertations

There are certain rights that are explicitly enumerated in the Constitution, e.g., right to bear arms, right to free speech, right to a speedy and public trial. There are also rights that aren’t specifically written out but are nevertheless enjoyed by people nationwide. Rights that aren’t explicitly mentioned in the Constitution, but which are fundamental to are called the unenumerated rights. Unenumerated rights are just as important and can be derived from natural law, enumerated rights, the Ninth Amendment, precedents, judicial opinions, and substantive due process.

Substantive due process is a principle guaranteed by the Fifth and Fourteenth Amendments, which …

Addressing Over-The-Counter Proton Pump Inhibitor Overuse: Strategies For Pharmacists To Enhance Patient Care, Brenna Hissong, Giang Nguyen, Alexander Defranco, Layla Dials, Jordyn Linfield, Haley Brown, Joshua Honaker, Samantha Mccord, Alaina Kortokrax

Pharmacy and Wellness Review

Proton pump inhibitors (PPIs) are among the most commonly prescribed and widely used medications for the treatment of gastrointestinal (GI) disorders. PPIs irreversibly inhibit the H+/K+-ATPase enzyme, effectively reducing gastric acid secretion and providing sustained relief for acid-related conditions. With the approval of over-the-counter (OTC) PPIs, the number of individuals taking these medications for prolonged periods of time without routine monitoring for the appropriateness of therapy has increased. The overuse of OTC PPIs can be attributed to a number of factors, including ease of access, perceived safety, inadequate understanding of OTC PPI treatment intervals, and a lack of awareness regarding …

Fda Approves Neffy®- First Nasal Spray For Anaphylaxis, Abigail Carter, Penlope Mazivanhanga, Haylee Whyde, Rileigh Rahrig, Ashley Jacob, Anna Spalvieri, Joshua Honaker, Samantha Mccord, Andrew Roecker

Pharmacy and Wellness Review

Between 1.6 and 5.1% of the United States population have experienced anaphylaxis, a severe allergic reaction.1 Anaphylaxis occurs when someone is exposed to an allergen, most commonly foods, medications, and insect venom. Epinephrine is the first-line agent for anaphylaxis treatment, and it is critical to administer this medication immediately after the onset of anaphylactic symptoms to prevent worsening that could lead to death. Epinephrine, more commonly known as EpiPen® or Auvi-Q®, has historically only been available as an intramuscular (IM) injection. Many people are afraid, anxious, or uneducated on how to properly give someone an IM injection, causing anaphylaxis treatment …

Fda Greenlights Early-Stage Trial For Investigational Long Covid Treatment: Phase Ii Evaluation Pending, Arin Wade, Maria Nguyen, Allie Honigford, Kennedy Kosikowski, Minhwan Yang, Rebecca Willier, Joshua Honaker, Samantha Mccord, Theresa Hempleman

Pharmacy and Wellness Review

Long coronavirus disease (COVID) is a condition that affects millions of individuals worldwide. Long COVID manifests as persistent symptoms following acute COVID-19. These symptoms can include, but are not limited to, fatigue, cognitive dysfunction, and chronic inflammation often lasting for months and significantly impairing patients' quality of life. As the number of Long COVID cases continues to rise and major global health organizations begin to standardize Long COVID’s mechanisms and diagnosis, there is an increasing demand for effective treatments that can address its complex nature. While some therapies, such as metformin and hyperbaric oxygen therapy (HBOT) have shown promise in …

Strict Liability And Coach Employment Contracts, Josh Lens

Seton Hall Law Review

No abstract provided.

Protecting The Integrity Of Sports, Matthew J. Parlow

Seton Hall Law Review

No abstract provided.

Prosecutors At The Front Line Of Nazi-Looted Art Restitution, Timothy O’Connor

Seton Hall Law Review

No abstract provided.

Organ-On-A-Chip Platforms For Drug Development, Cellular Toxicity Assessment, And Disease Modelling, Muhammad Maaz Khurram, Göktürk Ci̇nel, Özlem Yeşi̇l Çeli̇ktaş, Erdal Bedi̇r

Turkish Journal of Biology

Organ-on-a-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to mimic organ structures onto microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions at a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that recapitulate organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to portray their versatility in investigating drug safety, efficacy, and toxicity. We also reflect upon the potential of OoCs to effectively demonstrate disease models for probable novel therapeutics, …

Mechanistic Insights Into Cardiac Regeneration And Protection Through Meis Inhibition, Aynura Mammadova, Gali̇p Servet Aslan, Li Mo, Qifang Wu, Sebastian Clauss, Fati̇h Kocabaş

Turkish Journal of Biology

MEIS1, a member of the TALE-type homeobox gene family, has emerged as a pivotal regulator of cardiomyocyte cell cycle arrest and represents a promising therapeutic target. Our study reveals that inhibition of MEIS1 using two novel small molecules, MEISi-1 and MEISi-2, significantly enhances neonatal cardiomyocyte proliferation and cytokinesis. Specifically, MEISi-1 and MEISi-2 increased the proportion of proliferating cardiomyocytes (Ph3+TnnT cells) upto 4.5 fold and the percentage of cytokinetic cardiomyocytes (AuroraB+TnnT cells) by 2 fold, compared to untreated controls. MEIS1 inhibition resulted in a notable downregulation of MEIS1 target genes and cyclin-dependent kinase inhibitors, demonstrating its effect on key regulatory pathways. …

Chelidonic Acid Abrogates Oxidative Stress And Memory Dysfunction In Experimental Aging Rats, Feri̇de Ni̇hal Si̇nan, Emel Serdaroğlu Kaşikçi, Burcu Çevreli̇

Turkish Journal of Biology

Background/aim: In an aging model established in male Wistar albino rats via the administration of D-galactose (D-gal), the aim of this study was to examine the effects of chelidonic acid on cognitive functioning and the levels of glutathione (GSH), malondialdehyde (MDA), Total antioxidant status (TAS), and brain-derived neurotrophic factor (BDNF).Materials and methods: Thirty-two Wistar albino (three month old) male rats (n = 8) were used. Group 1: Control (C), Group 2: Chelidonic acid (CA) (2 mg/kg oral gavage), Group 3: D-galactose (D-gal) (150 mg/kg, s.c.), Group 4: D-gal (150 mg/kg) + CA (2 mg/kg) (DC). Following an overnight fast, the …

Characterization Of Tfiie-Regulated Genes By Transcriptome Analysis, Serdar Baysal

Turkish Journal of Biology

Previous studies on GTF2E showed that it has association with certain group of diseases such as colon cancer and trichothiodystrophy but what is the global effect of GTF2E on cellular processes is not widely characterized. In this regard, this study aimed to investigate and characterize the affect of GTF2E on transcription level of genes and identify the cellular processes and diseases associated with GTF2E. The HCT116 cell line was used in the study and transfected at 30 nM concentration with siGTF2E1 or non-target negative siRNA. After 72 hours, cells were harvested and prepared for further analysis. Whole transcriptome analysis was …

Optimizing Brake Bias In Formula Sae: A Framework For New And Existing Members, Benjamin Swonger

Mechanical Engineering and Materials Science Independent Study

Formula SAE cars undergo various events where different brake biases are beneficial. Brake bias, the percentage of braking force between the front and rear brakes, plays a crucial role in the car’s overall performance and safety. Correct tuning and diagnostic of the brake system greatly improves stability, minimizes wheel lock-up, and reduces the risk of under and oversteer. This report provides a framework methodology and analysis to optimize brake bias in most situations. The objective is to provide a base knowledge of the brake system that gives new team members a step-by-step guide that simplifies the brake bias calculation and …

Optimizing Mechanical Sensor And Actuator Implementation For Student Makerspace Applications, Nathalie Morton

Mechanical Engineering and Materials Science Independent Study

This independent study aims to create an advanced training module for the Makerspace on sensors and actuators for mechanical applications, guiding users toward more effective sensor selection, actuator control, implementation and troubleshooting of common issues. To support the development of the training module, extensive research was conducted on widely available sensors and actuators compatible with Arduino and Adafruit microprocessors, both of which are commonly available in student Makerspaces. In addition to online research, I reviewed popular maker websites and magazines, such as Make Magazine and Instructables, to identify components that are appropriate for introductory and intermediate-level projects. Through this process, …

Development Of Platform And Harness System For In Vivo Rat Elbow Range Of Motion Device And Confirmation Of Ulnar Nerve Integrity In Rats, Genevieve Jarrell

Mechanical Engineering and Materials Science Independent Study

This independent study in Dr. Lake’s Musculoskeletal Soft Tissue Lab focused on two main projects. The first was creating a platform and harness system to secure a rat while its elbow range of motion (ROM) was measured in vivo. Multiple prototypes were designed, 3D printed, and tested on a deceased animal, and each design was improved upon to yield more consistent results. The final prototype yielded semi-consistent results, with further improvements identified and planned. The second project focused on developing a protocol to confirm the integrity of a rat’s ulnar nerve after an ulnar collateral ligament (UCL) transection. Two methods …