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2024

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The Development, Implementation And Evaluation Of A Novel Intervention For Delirium Prevention And Management In An Adult Intensive Care Unit: A Mixed Methods Study, Gideon Ugochukwu Johnson Jan 2024

The Development, Implementation And Evaluation Of A Novel Intervention For Delirium Prevention And Management In An Adult Intensive Care Unit: A Mixed Methods Study, Gideon Ugochukwu Johnson

Theses: Doctorates and Masters

Background: Delirium is a prevalent acute brain dysfunction in patients within intensive care units. Delirium is marked by a fluctuating mental state, inattention, and altered consciousness. This condition affects a substantial proportion of patients in intensive care units, and which leads to increased mortality, severe physiological and psychological consequences, and a significant economic burden on healthcare systems. Despite the evidence that supports the use of non-pharmacological interventions to prevent or minimise the impact of delirium such as orientation, sensory stimulation, early mobilisation, and family involvement, their implementation in intensive care units remains inconsistent. The involvement of family members in the …


The Meme Stock Fenzy: Origins And Implications, Dhruv Aggarwal, Albert H. Choi, Yoon-Ho Alex Lee Jan 2024

The Meme Stock Fenzy: Origins And Implications, Dhruv Aggarwal, Albert H. Choi, Yoon-Ho Alex Lee

Articles

In 2021, several publicly traded companies, such as GameStop, Bed Bath & Beyond, and AMC, became “meme stocks,” experiencing a sharp rise in their stock prices through a dramatic influx of retail investors into their shareholder base. Analyses of the meme stock surge and its implications for corporate governance have focused on the idiosyncratic creation of online communities around particular stocks during the COVID-19 pandemic. In this Article, we argue that the emergence of meme stocks is part of longer-running and more structural digital transformations in trading, investing, and governance. On the trading front, the abolition of commissions by major …


Research Access To Social Media Data: Lessons From Clinical Trial Data Sharing, Christopher J. Morten, Gabriel Nicholas, Salomé Vilgoen Jan 2024

Research Access To Social Media Data: Lessons From Clinical Trial Data Sharing, Christopher J. Morten, Gabriel Nicholas, Salomé Vilgoen

Articles

For years, social media companies have sparred with lawmakers over how much independent access to platform data they should provide researchers. Sharing data with researchers allows the public to better understand the risks and harms associated with social media, including areas such as misinformation, child safety, and political polarization. Yet researcher access is controversial. Privacy advocates and companies raise the potential privacy threats of researchers using such data irresponsibly. In addition, social media companies raise concerns over trade secrecy: the data these companies hold and the algorithms powered by that data are secretive sources of competitive advantage. This Article shows …


Rethinking Innovation At Fda, Rachel E. Sachs, Nicholson Price, Patricia J. Zeitler Jan 2024

Rethinking Innovation At Fda, Rachel E. Sachs, Nicholson Price, Patricia J. Zeitler

Articles

In several controversial drug approval decisions in recent years, the Food & Drug Administration (“FDA”) has publicly justified its decision partly on the ground that approving the drugs in question would support innovation in those fields going forward. To some observers, these arguments were surprising, as the Agency’s determination whether a drug is “safe” and “effective” does not seem to depend on whether its approval also supports innovation. But FDA’s use of these innovation arguments in drug approval decisions is just one example of the ways in which the Agency has come to make many innovation-related judgments as part of …


Sins And Omissions: Slavery And The Bill Of Rights, Richard Primus Jan 2024

Sins And Omissions: Slavery And The Bill Of Rights, Richard Primus

Articles

According to the conventional story, the Constitutional Convention declined to include a bill of rights in the Constitution because it trusted the enumeration of congressional powers to do the necessary work of limiting the federal government. That conventional story is historically unfounded. It is not supported by contemporary evidence, and it was roundly disbelieved at the time. Although it is not possible to know for certain why (really, for what mix of reasons) the Framers omitted a bill of rights, it seems likely that one major reason was that formulating a bill of rights would have provoked a bitter fight …


Meme Corporate Governance, Dhruv Aggarwal, Albert H. Choi, Yoon-Ho Alex Lee Jan 2024

Meme Corporate Governance, Dhruv Aggarwal, Albert H. Choi, Yoon-Ho Alex Lee

Articles

Can retail investors revolutionize corporate governance and make public companies more responsive to social concerns? Beginning in 2021, there was a dramatic influx of retail investors into the shareholder base of “meme” stock companies such as GameStop, AMC, and Bed Bath & Beyond. Observing the unprecedented, coordinated trading among retail investors, scholars and practitioners predicted that the influx of retail investors would reduce the power of large institutional investors and democratize corporate governance. These predictions were driven by three factors: generational, with assumptions that millennial and Gen Z investors would challenge corporate management; societal, reflecting growing discontent with slow progress …


21st-Century Environmental Challenges And Revitalizing Epa Enforcement, David Uhlmann Jan 2024

21st-Century Environmental Challenges And Revitalizing Epa Enforcement, David Uhlmann

Articles

This is a profound moment for environmental protection efforts in our country. Over the past half-century, under presidents of both parties, we have made great progress addressing the challenges that led to the enactment of our environmental laws during the 1970s. Our air is cleaner, our rivers and streams are healthier, and we have far fewer hazardous waste sites. We have achieved those successes because of conscientious companies across America who meet their environmental obligations and the vigilance of the U.S. Environmental Protection Agency (EPA) and the Justice Department when companies break the law and put their profits before the …


Applying Strict Scrutiny In Termination Of Parental Rights Proceedings: Why Alabama’S Jurisprudence Should Reshape Child Protection Practice, Christopher Church, Vivek Sankaran Jan 2024

Applying Strict Scrutiny In Termination Of Parental Rights Proceedings: Why Alabama’S Jurisprudence Should Reshape Child Protection Practice, Christopher Church, Vivek Sankaran

Articles

“Our decision in [Pierce] holds that parents have a fundamental constitutional right to rear their children . . . . I would apply strict scrutiny to infringements of fundamental rights.” “[S]trict scrutiny leaves few survivors.” Termination of parental rights (TPR) stands as “a unique kind of deprivation” that results in the state irrevocably severing a parent’s fundamental right to care for their child. In The Ties that Bind Us, we scrutinized the child protection system’s overuse of TPR, employing clinical, empirical, and constitutional perspectives. This Article advocates for a constitutionally anchored framework aimed at enforcing strict scrutiny when considering TPR …


Taxation And Corporate Governance, Reuven S. Avi-Yonah, Ariel Siman Jan 2024

Taxation And Corporate Governance, Reuven S. Avi-Yonah, Ariel Siman

Articles

Legal and economic scholars have examined the intersection between corporate governance and taxation; however, recent legal scholarship has generally focused on the interplay between director compensation, management measures in the face of the market for corporate control, and the double taxation of inter-corporate dividends. Other aspects of the relationship between corporate governance and taxation have received limited attention. This article aims to fill this gap in the literature. First, this paper discusses the corporate agency problem and the existing justifications for the corporate tax. Second, this paper argues that the corporate tax can be justified on the ground that it …


Cognitive Dissonance In The Antebellum South About The Lawfulness Of Slavery, Peter K. Westen Jan 2024

Cognitive Dissonance In The Antebellum South About The Lawfulness Of Slavery, Peter K. Westen

Articles

The institution of slavery, by its nature, was necessarily grounded in law. For whenever a society adjudges one class of persons as free and another as enslaved, law-like norms must exist to identify and distinguish the free from the enslaved. And whenever a society institutionalizes slavery, law-like norms must exist to establish the privileges and disabilities possessed by masters, by the enslaved, and by third persons in relation to masters and slaves. Such master-slave norms may not always be enforced. But, until societies disavow or disremember them, they constitute standards of right and wrong that master-slave societies profess to embrace. …


Whither Lob?, Reuven S. Avi-Yonah Jan 2024

Whither Lob?, Reuven S. Avi-Yonah

Articles

On January 1, 2024, the 1979 tax treaty between the United States andHungary was officially terminated.A revised treaty was signed in 2010but was never ratified by the United States, and it is unlikely that it willcome into effect any time soon.This situation is an anomaly because the United States has tax treaties withmost other members of the European Union (EU) and the Organisation forEconomic Co-operation and Development (OECD). Why did the UnitedStates terminate the treaty in July 2022?


The Joy Of The Fight: What Litigators Can Learn From The Martial Arts, Len Niehoff, Tim Lynch Jan 2024

The Joy Of The Fight: What Litigators Can Learn From The Martial Arts, Len Niehoff, Tim Lynch

Articles

You walk into a martial arts training studio (in Japanese styles, a dojo) and you scan the room. Everything going on here looks, well, unpleasant. In one corner, you observe a group of students performing kata, choreographed sequences of kicks, punches, and blocks that simulate the experience of fighting multiple opponents. Sweat pours off them. In another corner, you see two students engaged in sparring exercises, or kumite. The sharp, smacking noise of one student striking the protective pads worn by another carries across the room. In a third corner, you notice students doing push-ups, working their muscles until their …


Brief Of A Former Federal Judge, Fair And Just Prosecution, 17 Law Professors, And 4 Domestic Violence Researchers And Advocates As Amici Curiae In Support Of Petitioner, Jamie Abrams Jan 2024

Brief Of A Former Federal Judge, Fair And Just Prosecution, 17 Law Professors, And 4 Domestic Violence Researchers And Advocates As Amici Curiae In Support Of Petitioner, Jamie Abrams

Amicus Briefs & Court Filings

While amici are not formally affiliated with each other and come from a variety of professional fields, they are all keenly aware of the pernicious effects of gender bias against female defendants in American courtrooms. Each is deeply familiar with the toll that gender bias exacts not only on the individual women whose interactions with the criminal legal system are tainted by it, but also on the quality, reliability, and fairness of the criminal legal system. Together they have a distinct interest in ensuring that inflammatory and prejudicial gendered stereotypes about how women should look, act, and comport themselves are …


The Molecular Landscape Of Sepsis Severity In Infants: Enhanced Coagulation, Innate Immunity, And T Cell Repression, Susie Shih Yin Huang, Mohammed Toufiq, Pirooz Eghtesady, Nicholas Van Panhuys, Mathieu Garand Jan 2024

The Molecular Landscape Of Sepsis Severity In Infants: Enhanced Coagulation, Innate Immunity, And T Cell Repression, Susie Shih Yin Huang, Mohammed Toufiq, Pirooz Eghtesady, Nicholas Van Panhuys, Mathieu Garand

2020-Current year OA Pubs

INTRODUCTION: Sepsis remains a major cause of mortality and morbidity in infants. In recent years, several gene marker strategies for the early identification of sepsis have been proposed but only a few have been independently validated for adult cohorts and applicability to infant sepsis remains unclear. Biomarkers to assess disease severity and risks of shock also represent an important unmet need.

METHODS: To elucidate characteristics driving sepsis in infants, we assembled a multi-transcriptomic dataset from public microarray datasets originating from five independent studies pertaining to bacterial sepsis in infant < 6-months of age (total n=335). We utilized a COmbat co-normalization strategy to enable comparative evaluation across multiple studies while preserving the relationship between cases and controls.

RESULTS: We found good concordance with only two out of seven …


Empowering Providers To Empower Their Patients: One Model To Expand Knowledge, Competency, And Awareness For The Perinatal Substance Use Workforce, Jacqueline Jacobs Jan 2024

Empowering Providers To Empower Their Patients: One Model To Expand Knowledge, Competency, And Awareness For The Perinatal Substance Use Workforce, Jacqueline Jacobs

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Perinatal substance use (PSU) is a serious and growing public health concern. It is associated with a variety of adverse health outcomes for both mother and child and has been shown to negatively impact the parent-child relationship. Despite the growing prevalence of PSU, there are notable deficits in provider knowledge regarding, and comfortability with, PSU. Moreover, providers report feelings of judgment, resentment, fear, and hesitancy related to their work with women with PSU. Subsequently, women with PSU struggle to find appropriate, compassionate, and effective treatment for their substance misuse. Widespread and accessible training is needed to bolster provider knowledge base, …


Regulatory Monitoring In The Information Economy, Brenda Dvoskin Jan 2024

Regulatory Monitoring In The Information Economy, Brenda Dvoskin

Scholarship@WashULaw

The administrative state is inadequately structured to define and implement public values related to the design and operation of digital architectures, systems, and processes. The Reimagining the Governance Stack Project at Georgetown Law is a long-term, full-stack effort to reinvent the administrative state so that it is capable of governing the information economy in accordance with public priorities. This first concept paper focuses on regulatory monitoring capacities. Agencies need new tools to monitor compliance with existing public mandates and understand the information economy in order to develop new and more effective regulation.


Police Diversity Theory, Trevor George Gardner Jan 2024

Police Diversity Theory, Trevor George Gardner

Scholarship@WashULaw

In light of both the tragic death of Tyre Nichols in Memphis at the hands of Black police officers and the mixed results of studies of Black same-race policing, this Article proposes a conceptual framework by which to better understand the utility of police diversity. The framework maps the relational possibilities among three factors: (i) the Black officer’s approach to same-race policing; (ii) the Black officer’s performance in the context of same-race policing; and (iii) the policing priorities of the Black communities the Black officer is taken to represent.

Responsive to the conceptual framework for police diversity theory, the Article …


The Vanishing Appeal?, Stefanie A. Lindquist, Kirk Randazzo Jan 2024

The Vanishing Appeal?, Stefanie A. Lindquist, Kirk Randazzo

Scholarship@WashULaw

Appellate filings in the United States Courts of Appeals demonstrate a considerable decline since 2006, following an historical trend in increasing caseloads throughout the twentieth century and early parts of the twenty-first. This phenomenon deserves evaluation. In this Article, we demonstrate the trend using data from the Administrative Office of the U.S. Courts and advance a number of potential hypotheses that might assist in explaining the trend, including decreasing trial rates, unique case type and circuit variations, trends in pro se litigation, and political explanations. Ultimately, the trend in case filings in the federal appellate courts is likely the product …


Diversity And Inclusion Trainings As A Public Relations Imperative: Addressing The Faragher - Ellerth Test Via Interest-Convergence And Targeted Universalism, Mary Marston Jan 2024

Diversity And Inclusion Trainings As A Public Relations Imperative: Addressing The Faragher - Ellerth Test Via Interest-Convergence And Targeted Universalism, Mary Marston

American University Journal of Gender, Social Policy & the Law

This Article argues that courts must adopt a nuanced and culturally sensitive approach when addressing discrimination claims related to culturally and racially significant hairstyles. Specifically, it suggests incorporating immutable characteristics of racial and religious expression as a foundational standard in evaluating such cases. This approach aims to ensure equitable consideration in the adjudication of Title VII sexual harassment claims and Title VII racial discrimination claims.


Queer: Litigating Gender Non-Conformity, Eliot Tracz Jan 2024

Queer: Litigating Gender Non-Conformity, Eliot Tracz

American University Journal of Gender, Social Policy & the Law

Section I of this article provides background information on the complexity of gender identity. This section addresses some of the different terminology used by members of the LGBTQ community to describe their gender identity, including the relatively well-known term “nonbinary” and continuing through to the less concrete term “queer.” Section II looks at the history of state action policing queer bodies and identities. It outlines statutes enacted to prevent individuals from hiding their identities and how such laws were used to target queer individuals. Section III discusses the case of Grimm v. Gloucester County School Boardand the two approaches …


The Very Interstate Nature Of The Internet? Establishing Uniform Requirements For Internet Transmissions Within Interstate And Foreign Commerce, Catherine Beal Jan 2024

The Very Interstate Nature Of The Internet? Establishing Uniform Requirements For Internet Transmissions Within Interstate And Foreign Commerce, Catherine Beal

American University Journal of Gender, Social Policy & the Law

This Comment argues that federal statutes, including the jurisdictional nexus of “transmission in interstate or foreign commerce,” should require evidence that a transmission actually traveled through interstate commerce to establish the required federal nexus. Part II of this article describes what threatening internet speech is, the development of the circuit split, and the statutory criteria at issue. Part III analyzes each side of the split and examines when statutory language permits an assumption of interstate or foreign transmission. Part III also proposes adopting a strict definition of “transmission in interstate and foreign commerce” for Internet-based speech and requiring evidence that …


The Prevalence And Characteristic Of Latent Tb In Patients On Immunosuppressant Agents And Biological Treatment, Tuqa Deia Khadhim, Basil Fawzi Jassar Jan 2024

The Prevalence And Characteristic Of Latent Tb In Patients On Immunosuppressant Agents And Biological Treatment, Tuqa Deia Khadhim, Basil Fawzi Jassar

Muthanna Medical Journal

LTTB is a common condition occurring in one fourth of those who were exposed to mycobacterial bacilli with Medically induced immunosuppression stands as a significant risk factor for having LTTB. Aim of the study: To assess the prevalence and characteristics of LTTB in patients on immunosuppressive agents and biological treatment. A cross-sectional research of 150 patients on immunosuppressants and biological therapy for diverse diseases at Baghdad teaching hospital outpatient rheumatology, dermatology, and TB clinics between 2023 and 2024 was done. All patients were examined with a detailed clinical history, physical exam, and chest x-ray or CT scan. IGRA testing was …


Management Of Postprocedural Conduction Disturbances Using A Prespecified Algorithm In The Optimize Pro Study., Kendra J Grubb, Steven J Yakubov, Tamim M Nazif, Suneet Mittal, Hemal Gada, Douglas G W Fraser, Joshua D Rovin, Ramzi Khalil, Robert T Pyo, Samin K Sharma, Mustafa Ahmed, Jian Huang, Josep Rodes-Cabau Jan 2024

Management Of Postprocedural Conduction Disturbances Using A Prespecified Algorithm In The Optimize Pro Study., Kendra J Grubb, Steven J Yakubov, Tamim M Nazif, Suneet Mittal, Hemal Gada, Douglas G W Fraser, Joshua D Rovin, Ramzi Khalil, Robert T Pyo, Samin K Sharma, Mustafa Ahmed, Jian Huang, Josep Rodes-Cabau

Heart and Vascular Articles

BACKGROUND: Lack of standardization in posttranscatheter aortic valve replacement (TAVR) conduction disturbance (CD) identification and treatment may affect permanent pacemaker implantation (PPI) rates and clinical outcomes. The safety and efficacy of a standardized TAVR CD algorithm has not been analyzed. This study analyzes the Optimize PRO post-TAVR CD management algorithm with Evolut PRO/PRO

METHODS: Optimize PRO is a prospective, postmarket study implementing 2 strategies to reduce pacemaker rates: TAVR with cusp overlap technique and a post-TAVR CD algorithm. The 2-hour postprocedural electrocardiogram (ECG) stratified patients to early discharge in the absence of new ECG changes or to CD algorithms for …


The Impact Of Hybrid Working On Employee Way Of Life And The Need To Reshape The Employee Value Proposition, Kanishka Chandanamali Athalage Jan 2024

The Impact Of Hybrid Working On Employee Way Of Life And The Need To Reshape The Employee Value Proposition, Kanishka Chandanamali Athalage

Dissertations

This dissertation details a post-pandemic qualitative investigation conducted to understand the impact of hybrid working solutions on reshaping the employee value proposition (EVP) in the health insurance industry of the UAE. The research aims to evaluate how the introduction of modern hybrid working solutions impacts employees in a post-pandemic environment and, in turn, whether this creates a demand for human resources to refocus drivers of the EVP. Traditionally, EVP is referred to as the overall give-and-get in an employment deal; however, the pandemic was an eye-opener for organizations to redefine what it entails. Since hybrid working has become the new …


Integrating Music In Pk-12 Classrooms To Impact Behavior, Improve Academics, And Support Developmental Milestones In Children, Emily Grace Manis Jan 2024

Integrating Music In Pk-12 Classrooms To Impact Behavior, Improve Academics, And Support Developmental Milestones In Children, Emily Grace Manis

Honors Program Theses

As a child, music was always a part of my life, and I believe this immersion has greatly impacted how I view music’s role in the world of education. I’ve always wanted to be a teacher, but it wasn’t until I started courses at the University of Northern Iowa that I really decided to focus on early childhood and social emotional learning. My desire to teach, combined with my passion for all things music, led to my decision to focus on how music integration can be a useful tool in every classroom. Specifically I want to focus the research and …


Why Play? Exploring The Realities Of Play-Based Learning In Kindergarten, Sofia Josephine Steele Jan 2024

Why Play? Exploring The Realities Of Play-Based Learning In Kindergarten, Sofia Josephine Steele

Honors Program Theses

By nature, children are curious and love to explore the world around them. Play is one way that children can fulfill that innate curiosity. Through play-based learning, educators can utilize that innate curiosity and wonder in children to create valuable learning experiences that will engage and teach them. This pedagogical approach is used in early childhood education to help children develop their academic, social, and emotional skills through appropriate learning experiences that consider their abilities and interests. However, in recent years, there has been a shift away from play-based learning in kindergarten classrooms. The reasoning behind this shift may be …


The Relationship Between Athletes' Competitive State Anxiety And Self-Confidence And Coaches' Behaviors, Derek Anderson Jan 2024

The Relationship Between Athletes' Competitive State Anxiety And Self-Confidence And Coaches' Behaviors, Derek Anderson

Honors Program Theses

Competitive state anxiety (CSA) and self-confidence are prominent issues in athletics and can cause detrimental effects on athletic performance. The purpose of this study is to analyze the effects of perceived coach anxiety and perceived coach self-confidence on athlete competitive state anxiety and self-confidence. It was predicted that as perceived coach anxiety increases, athlete competitive anxiety will increase. Furthermore, as perceived coach self-confidence decreases, athlete self-confidence will decrease. Ninety-six Division I athletes from three sports (men’s/women’s track and field, women’s soccer, women’s softball) were recruited. Participants ranged in age from 18 to 25 years of age (M = 20.33, SD …


The Ncaa's Challenge In Determining Nil Market Value, Meg Penrose Jan 2024

The Ncaa's Challenge In Determining Nil Market Value, Meg Penrose

Faculty Scholarship

This Article proceeds in three parts. Part II discusses the changes that NIL has wrought in college athletics. It briefly explains collectives and their impact on NIL. Part III discusses the impossibility of limiting athletes’ “fair market value” given market value depends on what the market is willing to pay. Congress has failed to pass national legislation. Yet the mosaic of state laws is simply unfit to stand in for national legislation. And, following multiple litigation losses, the NCAA cannot be trusted to “value” the athletes themselves. Market value, if one is to be established, must be uniform and assessed …


North American Energy In The Crossfire, Guillermo J. Garcia Sanchez, James W. Coleman Jan 2024

North American Energy In The Crossfire, Guillermo J. Garcia Sanchez, James W. Coleman

Faculty Scholarship

North America is the beating heart of global energy markets un-dergoing a terrible energy crisis that threatens to upend both the economy and global security. The clearest path out of this global crisis is increasing energy supplies from North America, which can restore energy security and drive a transition to cleaner energy sources. The U.S., Mexico, and Canada have abundant and varied resources to surmount this challenge but are in dire need of stronger cooperation across borders, and between private and public actors to achieve this goal. This Article shows how energy law changes in the U.S. and Mexico present …


Virtual Energy, Joel B. Eisen, Felix Mormann, Heather E. Payne Jan 2024

Virtual Energy, Joel B. Eisen, Felix Mormann, Heather E. Payne

Faculty Scholarship

From employment to education, many areas of our daily lives have gone virtual, including the virtual workplace and virtual classes. By comparison, the way we generate, deliver, and consume electricity is an anachronism. And the electric industry’s outdated business model and regulatory framework are failing. For the last century-and-a-half, we have relied on ever larger power plants to generate the electricity we consume, often hundreds of miles away from the point of production. But the outsized carbon footprint of these power plants and the need to transmit their output over long distances threaten the electric grid’s reliability, affordability, and long-term …