Digital Commons Network^™

Performing Britishness: Identity And Popular Music Tribute Shows In Perth, Western Australia, Colin Outhwaite

Theses: Doctorates and Masters

This research investigates how and why individuals use popular music tribute shows to construct individual and collective identities within the British expatriate community in Perth, Western Australia. Popular music tribute shows involve recontextualised performances of past musical works and rely on shared first-hand or vicarious experiences between musicians and audiences. By examining how individuals and groups use music as a means for strengthening and maintaining cultural identity, the research investigates how musical activity is both a result and influence on the construction and perpetuation of a symbolic and temporal identity group that revolves around shared tastes and experiences.

Transformative Career Theory: A Grounded Theory Study Into The Long-Term Careers Of Australian Youth Workers, John Sutcliffe

Theses: Doctorates and Masters

This study explores the long-term careers of professional youth workers in Australia with the aim of developing a relevant theory of career grounded in their experiences. Despite the importance of youth work, only a small number of studies has been undertaken on youth work careers both in Australia and internationally. Previous research by the author in 2021 contributed to understanding the long-term youth work career for graduate youth workers in Western Australia, but further data are needed to build a transferable theory or framework. The research problem is clear: what does a career in youth work entail and how can …

Diagnosing Innovation: A Design-Led Approach To Cultivate Innovation In The Western Australian Public Health System, Sash Milne

Theses: Doctorates and Masters

Recent research highlights the significance of design-led approaches, such as human-centred design, in fostering an innovative culture within complex public systems like public health. However, transforming systemic culture on a large scale presents a formidable challenge, constituting its own "wicked problem" that is both a fertile ground for design intervention and exceptionally difficult to tackle.

My research employs a design-led research perspective to investigate the current state of innovation culture within WA Health and to identify potential leverage points for future cultural transformation. Utilising data gathered from interviews and workshops, this research project sheds light on the multifaceted barriers confronting …

Transcriptional Precision In Photoreceptor Development And Diseases - Lessons From 25 Years Of Crx Research, Yiqiao Zheng, Shiming Chen

2020-Current year OA Pubs

The vertebrate retina is made up of six specialized neuronal cell types and one glia that are generated from a common retinal progenitor. The development of these distinct cell types is programmed by transcription factors that regulate the expression of specific genes essential for cell fate specification and differentiation. Because of the complex nature of transcriptional regulation, understanding transcription factor functions in development and disease is challenging. Research on the

Factors Associated With Never Treatment And Acceptability Of Mass Drug Administration For The Elimination Of Lymphatic Filariasis In Guyana, 2021, Claudia Duguay, Reza A. Niles-Robin, Charles R. Thickstun, Horace Cox, Annastacia Sampson, Jean Seme-Fils Alexandre, Nathely Caleb-Mars, Charles W. Goss, Ana Morice, Ronaldo G. Carvalho Scholte, Alison Krentel

2020-Current year OA Pubs

Guyana remains one of four countries in the Americas endemic for lymphatic filariasis (LF). Elimination of LF requires repeated annual mass drug administration (MDA) with sufficient levels of coverage for success. This study assesses the acceptability and never treatment of LF MDA using data from a routine assessment survey in 2021. A subset of individuals, over 20 years of age (n = 2498), were selected to receive an expanded questionnaire to examine factors associated with acceptability and never treatment. Assessed factors include respondent demographics, knowledge, risk perceptions of LF, and opinions on the MDA programme. The majority (73%) of those …

The Response Of Dual-Leucine Zipper Kinase (Dlk) To Nocodazole: Evidence For A Homeostatic Cytoskeletal Repair Mechanism, Laura Devault, Chase Mateusiak, John Palucki, Michael Brent, Jeffrey Milbrandt, Aaron Diantonio

2020-Current year OA Pubs

Genetic and pharmacological perturbation of the cytoskeleton enhances the regenerative potential of neurons. This response requires Dual-leucine Zipper Kinase (DLK), a neuronal stress sensor that is a central regulator of axon regeneration and degeneration. The damage and repair aspects of this response are reminiscent of other cellular homeostatic systems, suggesting that a cytoskeletal homeostatic response exists. In this study, we propose a framework for understanding DLK mediated neuronal cytoskeletal homeostasis. We demonstrate that low dose nocodazole treatment activates DLK signaling. Activation of DLK signaling results in a DLK-dependent transcriptional signature, which we identify through RNA-seq. This signature includes genes likely …

Arid1a Loss Is Associated With Increased Nrf2 Signaling In Human Head And Neck Squamous Cell Carcinomas, Vinh Nguyen, Travis P. Schrank, Michael B. Major, Bernard E. Weissman

2020-Current year OA Pubs

Prior to the next generation sequencing and characterization of the tumor genome landscape, mutations in the SWI/SNF chromatin remodeling complex and the KEAP1-NRF2 signaling pathway were underappreciated. While these two classes of mutations appeared to independently contribute to tumor development, recent reports have demonstrated a mechanistic link between these two regulatory mechanisms in specific cancer types and cell models. In this work, we expand upon these data by exploring the relationship between mutations in BAF and PBAF subunits of the SWI/SNF complex and activation of NRF2 signal transduction across many cancer types. ARID1A/B mutations were strongly associated with NRF2 transcriptional …