Digital Commons Network^™

Advancing Real-World Implementation Of The Well Optimized Linear Finder (Wolf) High-Speed Atmospheric Turbulence Compensation Method, Timothy Evan Coon

Theses and Dissertations

This dissertation advances the real-world implementation of the Well Optimized Linear Finder (WOLF) method for high-speed Atmospheric Turbulence Compensation (ATC). Atmospheric turbulence introduces phase aberrations into optical wavefronts and degrades image quality in terrestrial imaging systems. Traditional phase diversity methods are computationally intensive and poorly suited to real-time operation. The WOLF method addresses these limitations through a novel, point-wise formulation of the optical transfer function (OTF) as a structured autocorrelation of the generalized pupil function (GPF). This formulation enables the estimation of phase aberrations at individual spatial coordinates with distributed computational complexity.

The research begins by developing a MATLAB-based simulation …

Ambient Documentation Technology In Clinician Experience Of Documentation Burden And Burnout, Jacqueline G You, Reema H Dbouk, Adam Landman, David Y Ting, Sayon Dutta, Julie C Wang, Amanda J Centi, Molly Macfarlane, Eran Bechor, Jonathan Letourneau, Gabrielle Choo-Kang, Esther H Kim, Cordula Magee, Brian J Lang, Laura Angelo, Jackson Olin, Michelle Frits, Christine Iannaccone, Angela Rui, Ivana Salmikova, Christopher Holland, Bryan Blanchette, Rachel Silverman, David W Bates, Lisa Rotenstein, Rebecca G Mishuris

Faculty, Staff and Students Publications

Importance: Documentation burden is associated with clinician burnout. To address documentation burden, Mass General Brigham (MGB) in Somerville, Massachusetts, and Emory Healthcare in Atlanta, Georgia, have piloted ambient documentation technology (ADT), which develops artificial intelligence-drafted clinical notes from clinician-patient conversations.

Objective: To examine the prevalence of ADT use and its association with clinicians' experience of documentation burden and burnout before and after use.

Design, setting, and participants: This survey study included clinicians who used ADT for at least 42 days and responded to both the pre- and postsurveys (onboarded February 27 to July 31, 2024, at MGB and July 19, …

The Splicing Factor Kinase Srpk1 Is A Therapeutic Target For Peripheral Vascular Disease, Sohni Ria Bhalla, Mussarat Wahid, Jason O Amartey, Amira Zawia, Federica Riu, Yizhuo Gao, Jyoti Agrawal, Amy P Lynch, Maria J C Machado, Tom Hawtrey, Ryosuke Kikuchi, Kathryn R Green, Lydia Teboul, Claire Allen, Zoe Blackley, Keerthana Rajaji, Jennifer Batson, Steven J Harper, Sebastian Oltean, Winfried Amoaku, Andrew V Benest, Jonathan C Morris, Bruce Braithwaite, David O Bates

Faculty, Staff and Students Publications

In peripheral arterial disease (PAD), antiangiogenic VEGF-A165b isoform overexpression in monocytes contributes to impaired collateralization. Serine-arginine protein-kinase-1 (SRPK1) regulates VEGF splicing. To determine whether SRPK1 controlled monocytic VEGF, impairing collateralization, we investigated SRPK1 inhibition and monocyte-specific knockout in mouse models of and in human monocytes from PAD. VEGF-A165b activity was measured by coculture of monocytes from patients with PAD with endothelial cells with SRPK1 inhibition. Mice with impaired revascularization due to soluble-frizzled-related-protein-5 knockout (Sfrp5-/-), monocyte-specific Wnt5a gain-of-function (LysM-Wnt5aGOF), or obese mice on a high-fat high-sucrose (HF/HS) diet were subjected to femoral artery ligation and treated with …

Nanotechnology For Immuno-Oncology, Adam J Grippin, Daeyong Lee, Eileen E Parkes, Wen Jiang, Betty Y S Kim

Faculty, Staff and Student Publications

Although the first generation of cancer immunotherapeutics produced unprecedented improvements in clinical outcomes for individuals with cancer, novel strategies to increase treatment specificity, delivery efficiency and pharmacokinetics are still needed. In this Review, we describe the potential advantages and current limitations of nanomaterials for cancer immunotherapy and highlight rational uses of nanosystems to generate potent and durable antitumor immune responses. We close with a review of the current state of clinical development of nanomedicine for cancer immunotherapy.

Mitophagy’S Impacts On Cancer And Neurodegenerative Diseases: Implications For Future Therapies, Jason Huang, Vincent Truong Pham, Shaozi Fu, Gang Huang, Ya-Guang Liu, Lei Zheng

Faculty, Staff and Student Publications

Substantial evidence supports an inverse relationship between cancer and neurodegenerative diseases (NDDs), but few studies investigate the biological mechanisms underlying this phenomenon. While previous explanations-such as inflammation, reactive oxygen species (ROS), genetic mutations, and cell death-remain significant, they ultimately converge on mitophagy. This review identifies mitophagy as a pivotal factor in the development of both cancer and NDDs, while also evaluating specific mechanisms and processes to clarify how mitophagy connects these opposing disease trajectories. By examining these factors, we aim to uncover the underlying mechanisms that explain the inverse relationship between cancer and NDDs, which will help develop therapeutic strategies …

Pparγ-Induced Upregulation Of Fatty Acid Metabolism Confers Resistance To Venetoclax And Decitabine Therapy In Aml, Kotoko Yamatani, Tatsuro Watanabe, Kaori Saito, Abdullah Khasawneh, Abhishek Maiti, Zhihong Zeng, Kala Hayes, Shinya Kimura, Courtney D Dinardo, Xiaoping Su, Shuko Nojiri, Yasushi Okazaki, Michael Andreeff, Marina Konopleva, Yoko Tabe

Faculty, Staff and Student Publications

The combination of the B-cell lymphoma 2 (BCL2) inhibitor venetoclax (VEN) and the hypomethylating agent decitabine (DEC; VEN/DEC) constitutes a primary therapeutic strategy for treating older adults with acute myeloid leukemia (AML). However, a notable subset of patients exhibits resistance to VEN/DEC, demonstrating either no disease response or relapse after initial remission. This study aimed to elucidate the molecular mechanisms underlying this resistance through analyses of gene expression and DNA methylation profiles. We conducted comprehensive RNA sequencing analysis and DNA methylation profiling on AML samples from 35 patients undergoing VEN/DEC therapy. The RNA sequencing analysis revealed that several genes related …

The Unending Constant, Christopher Banyas

Journal of Humanistic Mathematics

No abstract provided.

Found Poem By Abraham De Moivre, Richard Delaware

Journal of Humanistic Mathematics

No abstract provided.

From Shudu [Sudoku 數獨] To Dushu [Learning Of Mathematics 讀數]?, Man Keung Siu

Journal of Humanistic Mathematics

The puzzle game Sudoku has been popular for over two decades, and even at one time became a craze for the public. This paper will briefly describe what the game is, a little bit of its history, and how to play it, but will leave the details to the many published books about the game. Some interesting and difficult mathematical problems relevant to the game will be highlighted, again leaving the detailed discussion to specific books published on this issue. The main point the paper tries to focus on is a discussion on the cognitive and the psychological aspects of …

A Dualistic Interpretation Of Mathematical Creation Through Art And Argumentation, Sofia Almpani, Petros Stefaneas, Mihir Chakraborty

Journal of Humanistic Mathematics

Creativity, informal reasoning and dynamic exchange of ideas form the pulsating heart of mathematical creation. In this approach, the concept of a mathematical object surpasses conventional boundaries of formal presentation, as they also encompass the intention to prove, significant creative stages within the proving, and the overall experience of prover's journey, which may involve arguments, debates, discovery insights, aesthetic visualizations, and narrative elements. In this paper we present two conceptual frameworks, namely Argumentation-based Proof-Events Calculus (APEC) and Mathematical RUPAs, in order to provide distinct yet interconnected perspectives on informal thinking, knowledge creation, and proving in mathematics. Following the two perspectives, …

On Gödel’S Incompleteness Theorem, David Pierce

Journal of Humanistic Mathematics

Gödel’s Incompleteness Theorem is about the logic of mathematics. It is that a certain mathematical structure is so rich that its theory cannot be completely axiomatized. This means there will always be true statements about the structure that cannot be proved as theorems from previously given axioms. To give meaning to this conclusion, we review some examples of mathematical theorems, and their proofs, in geometry, algebra, and logic; we also give an example of a structure that is so simple (while still being interesting) that its theory can indeed be completely axiomatized. First we look at a couple of popular …

Evaluating Methods Used To Quantify Racial Segregation, Sarah Cannon, Zarina Dhillon

Journal of Humanistic Mathematics

Racial segregation has long been a problem in communities across the United States. One approach to help understand such an important issue is to attempt to describe it quantitatively. Many metrics have been developed, all with various strengths and weaknesses, but none fully capture the nuances of this complicated issue. This work provides an overview of four of the mathematical approaches that have been developed to study segregation, explains how they function using small examples, and compares and contrasts their effectiveness in various situations. We then focus on segregation in Los Angeles (LA) County, including a detailed exploration of the …

Graphical Timetables As A Real-Life Example Of Different Representations Of Functions, Olav G. Imenes

Journal of Humanistic Mathematics

This paper examines 203 pre-service teachers' reactions and learning when they were introduced to a real-life situation in which it is natural to publish officially both graphs and tables of a given function: the situation of operating a railway. I found that almost all the pre-service teachers managed the easiest tasks, like calculating speeds, distances, and time for train represented by graphs. However, the more complicated tasks, which required interpretations of the graphs and tables, such as planning for a delayed train, finding which trains were locals, freight trains etc., were more difficult for them to grasp. There were few …

Front Matter

Journal of Humanistic Mathematics

No abstract provided.

The Tax Adviser, Volume 12, Number 11, November 1981, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

Washington Report: Tax Division Comments On Sec. 385 Regs., Kenneth F. Thomas, Peter F. Zimmermann, American Institute Of Certified Public Accountants. Federal Tax Division

Tax Adviser

No abstract provided.

Tax Clinic, Darwin Broenen

Tax Adviser

No abstract provided.

Highlights Of The Economic Recovery Tax Act Of 1981, Gerald W. Padwe, David D. Green

Tax Adviser

No abstract provided.

Critique Of Practical Reason, Immanuel Kant

Hannah Arendt Marginalia - All

Indianapolis, IN : Bobbs-Merrill, ©1956

Call #: BF2773.E5 B4 1956

Contains underlining and marginalia

PDF Information: 48 pages – 3 MB

Critique Of Pure Reason, Immanuel Kant

Hannah Arendt Marginalia - All

Macmillan: St Martin’s Press, 1963

Call #: B2778 .E5 S5

Contains marginalia.

PDF Information: 247 pages – 112.5mb

Kant’S Political Writings, Immanuel Kant

Hannah Arendt Marginalia - All

Cambridge, University Press, 1970

Call #: JC181 .K295

Contains marginalia, underlining and marginal lining.

PDF Information: 48 pages – 21mb

Critique Of Judgement, Immanuel Kant

Hannah Arendt Marginalia - All

New York, Hafner Pub. Co. [c1951, 1964]

Call #: B 2783 .E5 B5 1964

Contains underlining, marginal lining

PDF Information: 119 pages – 61 MB

The Complete Jefferson, Thomas Jefferson

Hannah Arendt Marginalia - All

New York, Distributed by Duell, Sloan & Pearce, Inc. [1943]

Call #: E302 .J4564

Contains marginalia, underlining, marginal lining and endpaper notes

PDF Information: 43 pages – 3 MB

The Life And Selected Writings Of Thomas Jefferson, Thomas Jefferson

Hannah Arendt Marginalia - All

New York: The Modern library, 1944

Contains light underlining and marginalia.

Call #: E332 .J47

PDF Information: 35 pages – 13.7mb

The Gnostic Religion; The Message Of The Alien God And The Beginnings Of Christianity, Hans Jonas

Hannah Arendt Marginalia - All

Boston, Beacon Press [1958]

Call #: BT1390 .J62

Contains marginalia, underlining, marginal lining and is inscribed by author

PDF Information: 70 pages – 5 MB

The Phenomenon Of Life: Toward A Philosophical Biology, Hans Jonas

Hannah Arendt Marginalia - All

New York, Harper & Row, 1966

Call #: BD431 .J48

Contains underlining and marginal lining.

PDF Information: 21 pages – 14mb

The Perennial Scope Of Philosophy, Karl Jaspers

Hannah Arendt Marginalia - All

New York, Philosophical Library [c1949]

Call #: B3279.J33 P33

Contains marginalia, underlining, marginal lining and is inscribed by J.M. Cuddihy

PDF Information: 40 pages – 29.6 MB

Aristotle; Fundamentals Of The History Of His Development., Werner Jaeger

Hannah Arendt Marginalia - All

London, Oxford University Press, 1962

Call #: B485 .J33 1962

Contains marginalia, underlining, marginal lining and endpaper notes.

PDF Information: 77 pages – 54 mb

Paideia: The Ideals Of Greek Culture V.1, Werner Jaeger

Hannah Arendt Marginalia - All

New York: Oxford university press, 1939-

Contains endpaper notes.

Call #: DF77 .J27

PDF Information: 64 pages – 64.7mb