Digital Commons Network^™

Extending The Icb Boundary Beyond Drug Substance (Roundtable Workshop), Michael Coolbaugh, Doug Hausner

Integrated Continuous Biomanufacturing VI

Please click Additional Files below to see the full abstract.

Converting A Commercial Fed-Batch Process To Continuous Manufacturing, Andrea Squeri, Robert Luo, Ken Lee, Jon Coffman

Integrated Continuous Biomanufacturing VI

Please click Additional Files below to see the full abstract

Credentialing Care: Covid-19 And The Bureaucratization Of Doulas, Ellen Block, Julie Johnson Searcy, Angela N. Castañeda

Sociology Faculty Publications

Doulas in the United States offer embodied, informational, and continuous one-on-one care to birthing people. Doulas have historically sought certification to gain knowledge through training and to gain legitimacy for healthcare providers and clients. During the COVID-19 pandemic, hospitals required doulas to provide proof of certification. The COVID-19 pandemic, and the proliferation of state-sponsored doula programs, has sparked a shift in how doulas are viewed and regulated, enabling new forms of bureaucratic oversight and control. Based on participant observation, surveys, and semi-structured interviews, we examine the connection between certification and care including motivations doulas have for certification, the perceived value …

The Rider (2024-10-21), Natalie Lapsley

The Rider Archives

Vol.10 No.9

Ignite Scholarship Helps Mccoy Stowe Fulfill Goal Of Becoming A Neurosurgeon, Office Of University Communications, Makella Knowles

Gardner-Webb NewsCenter Archive

Matthew “McCoy” Stowe, a double major in biomedical sciences and chemistry with a minor in psychology, is a junior dedicated to getting into medical school. Growing up in Lincolnton, N.C., only 40 minutes from campus, Gardner-Webb University was frequently talked about by his family and friends during high school.

Credentialing Care: Covid-19 And The Bureaucratization Of Doulas, Ellen Block, Julie Johnson Searcy, Angela N. Castañeda

Sociology & Anthropology Faculty publications

Doulas in the United States offer embodied, informational, and continuous one-on-one care to birthing people. Doulas have historically sought certification to gain knowledge through training and to gain legitimacy for healthcare providers and clients. During the COVID-19 pandemic, hospitals required doulas to provide proof of certification. The COVID-19 pandemic, and the proliferation of state-sponsored doula programs, has sparked a shift in how doulas are viewed and regulated, enabling new forms of bureaucratic oversight and control. Based on participant observation, surveys, and semi-structured interviews, we examine the connection between certification and care including motivations doulas have for certification, the perceived value …

Magnetic Resonance Imaging Of Ultrasound Fields For Visualization And Measurement Of Pressure Amplitudes, Paul-Emile Victor Passe-Carlus

Theses and Dissertations

In vivo pressure estimations for therapeutic ultrasound has the potential of rendering treatments using non-invasive ultrasound targeting safer and more reliable. By quantifying pressures and their respective spatial locations, better acoustic predictions and models can be made. In this thesis, we aim to measure a pressure field from a piezo-electric transducer through a ballistic gel medium by using an external gradient coil to encode the pressure field in a way that can be read and quantified using an MRI scanner. We describe the methods and the results pertaining to visualizing a pressure field. The setup was able to capture pressure …

Development Of Temperature Measurement And Control Of 3d Printed Microfluidic Devices Towards Biomolecular Analysis, Derek A. Sanchez

Theses and Dissertations

Microfluidics are devices with channels or reservoirs that have dimensions in the range of micrometers. They have an increasing role in biological analysis processes due to their ability to use very small sample volumes. Many microfluidic processes rely heavily on precise temperature measurement and control. Advances in 3D printing have led to high resolution digital light processing stereolithography (DLP-SLA) printers capable of using bio-compatible materials, available at BYU. This custom 3D printer has a resolution of 7.6 µm in the XY plane and 10 µm in the Z axis. Combined with a custom-made resin, we can produce microfluidic features as …

Harnessing The Potential Of Several Local Indonesian Tuber-Derived Starches As Pharmaceutical Excipients, Ronald Horison, Silvia Surini

Pharmaceutical Sciences and Research

Starch is one of the widely required excipients in pharmaceutical dosage forms manufacturing. Indonesia’s rich biodiversity, encompassing tubers like arrowroot, taro beneng, porang, ganyong and yams, harbours the potential for novel starch excipient sources. These tubers provide starch variations with distinct functional properties influenced by the natural starch granules’ properties and amylose-amylopectin ratio. Previous research utilizing natural and modified starches from these tubers has demonstrated their potential in pharmaceutical formulation. These starch tubers have been studied and provided promising results in tablet formulation and film development. Additionally, they could be involved in developing more advanced dosage forms, such as starch …

The Attitudes, Perceptions, And Motivations Of Student-Athletes In Intermediate Algebra, Alexandra Green

USF Tampa Graduate Theses and Dissertations

This research delves into the attitudes, perceptions, and motivations of student-athletes enrolled in Intermediate Algebra courses. It focuses on the distinct challenges they encounter in juggling academic and athletic responsibilities at a southeastern university in the United States. Employing a mixed-methods approach, the study gathered quantitative data through surveys to assess students' attitudes, perceptions, and motivations toward learning mathematics, as well as to determine the influence of their instructors on these factors. The qualitative segment provided deeper insights into their personal experiences, shedding light on their prior encounters with mathematics, their most memorable moments during the current course, and their …

Ferroptotic Cardiomyocytes Regulate Angiogenesis In The Regenerative Mouse Heart After Myocardial Infarction Through Direct And Indirect Mechanisms, Rebecca Ashley Stairley

MUSC Theses and Dissertations

Cardiovascular diseases (CVDs) are the leading cause of death in the United States, and heart attack occurs every 40 seconds in the US. A myocardial infarction (MI), or heart attack, results in ischemic injury and cardiomyocyte (CM) death. Mature mammalian CM renewal in the heart is insufficient to repopulate the lost tissue. However, the neonatal mouse heart retains its regenerative capacity through the first week of life, providing a valuable model to identifying regenerative factors.

Recent work by our lab revealed that the main mechanism of CM death in the heart post-MI is ferroptosis. In this study, we investigate the …

Design And Analysis Of Optimal Energy Efficient Routing Protocols For Lifetime Maximization And Qos Enhancement In Wireless Body Area Networks, Karthikeyan S

Theses and Dissertations

In recent times, Wireless Body Area Networks (WBAN) a subsection of Wireless Sensor Networks (WSN) a promising technology for the future healthcare realm with cutting-edge technologies that can assist healthcare professionals like doctors, nurses and biomedical engineers which enables one-to-one care by implementing Tele-Medicine and Tele-Health solutions. Machine Learning (ML) and Internet of Things (IoT) enabled medical big data is the future of the healthcare sector and Medical Technology-based industries leading to applications in other sectors such as fitness tracking for commercial purposes, Sportsperson health monitoring to track their day-to-day activities and wearable devices for critical and emergency care.

Recent …

Current Understanding Of The Impact Of United States Military Airborne Hazards And Burn Pit Exposures On Respiratory Health, Janeen Trembley, Paul Barach, Julie Tomáška, Jedidah Poole, Pamela Ginex, Robert Miller, Jacob Lindheimer, Anthony Szema, Kimberly Gandy, Trishul Siddharthan, Jason Kirkness, Joshua Nixon, Rosie Lopez Torres, Mark Klein, Timothy Nurkiewicz, Tammy Butterick

College of Population Health Faculty Papers

Millions of United States (U.S.) troops deployed to the Middle East and Southwest Asia were exposed to toxic airborne hazards and/or open-air burn pits. Burn pit emissions contain particulate matter combined with toxic gasses and heavy metals. Ongoing research has demonstrated that exposures to the airborne hazards from military burn pits have profound and lasting health and wellness consequences. Research on the long-term health consequences of exposure to open burn pits has been limited. Work continues to understand the scope of the health impacts and the underlying pathobiology following exposures and to establish care standards. The U.S. Sergeant First Class …

Identification Of New Leads Against Ubiquitin Specific Protease-7 (Usp7): A Step Towards The Potential Treatment Of Cancers, Sumaira Javaid, Seema Zadi, Muhammad Awais, Atai-Tul Wahab, Humaira Zafar, Innokentiy Maslennikov, M. Iqbal Choudhary

Pharmacy Faculty Articles and Research

Ubiquitin-specific protease-7 (USP7) is an important drug target as it regulates multiple proteins and genes (such as MDM2 and p53) with roles in cancer progression. Its inhibition can hinder the function of oncogenes, increase tumor suppression, and enhance immune response. The current study was designed to express USP7 in a prokaryotic system, followed by screening of small molecules against it using biophysical methods, primarily STD-NMR technique. Among them, 12 compounds showed interaction with USP7 as inferred from NMR-based screening. These compounds further caused destabilization of USP7 by reducing its melting temperature (T_m) up to 6 °C in …

Sexual Dimorphism In Impairment Of Acetylcholine-Mediated Vasorelaxation In Zucker Diabetic Fatty (Zdf) Rat Aorta: A Monogenic Model Of Obesity-Induced Type 2 Diabetes, Rifat A. Islam, Xiaoyuan Han, Sonali Shaligram, Mitra Esfandiarei, John N. Stallone, Roshanak Rahimian

Pacific Faculty Work

Several reports, including our previous studies, indicate that hyperglycemia and diabetes mellitus exert differential effects on vascular function in males and females. This study examines sex differences in the vascular effects of type 2 diabetes (T2D) in an established monogenic model of obesity-induced T2D, Zucker Diabetic Fatty (ZDF) rats. Acetylcholine (ACh) responses were assessed in phenylephrine pre-contracted rings before and after apocynin, a NADPH oxidase (NOX) inhibitor. The mRNA expressions of aortic endothelial NOS (eNOS), and key NOX isoforms were also measured. We demonstrated the following: (1) diabetes had contrasting effects on aortic vasorelaxation in ZDF rats, impairing relaxation to …

Antibacterial Activity And Phylogeny Of Griseofulvin Producing Aspergillus And Penicillium Species From Kunduchi Mangrove Sediments, Tanzania, Blandina A. Mavoa, Shaaban A. A. Kassuwi, Juma M. Hussein

Tanzania Journal of Science

Marine fungi are an underrated reservoir of bioactive metabolites for drug discovery. This study focused on fungi isolated from Kunduchi mangrove sediments in Tanzania. In an attempt to investigate the antibacterial activities of marine fungi and uncover their bioactive compounds, ethyl acetate crude extracts of fungal isolates were screened for antibacterial activity against human pathogens (Bacillus subtilis, Staphylococcus aureus and Escherichia coli) followed by compounds identification by Gas Chromatography-Mass Spectrometry (GC/MS). A total of seven fungal isolates were obtained from sediments. Crude extracts from isolate 1 and isolate 2 exhibited significant antibacterial activities with a Minimum Inhibitory Concentration ˃ 3.13 …

Α4 Nicotinic Acetylcholine Receptors In Lipopolysaccharide-Related Lung Inflammation, J. Ritzenthaler, Walter H. Watson, Jesse Roman

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

Sepsis remains an important healthcare challenge. The lungs are often affected in sepsis, resulting in acute lung injury characterized by inflammation. Mechanisms involving lipopolysaccharide (LPS) stimulation of toll-like receptor (TLR) signaling with induction of proinflammatory pathways have been implicated in this process. To date, however, studies targeting these pathways have failed to improve outcomes. We have found that LPS may also promote lung injury through the activation of α4 nicotinic acetylcholine receptors (α4 nAChRs) in immune cells. We observed increased expression of α4 nAChRs in human THP-1 monocytic cells exposed to LPS (100 ng/mL, 24 h). We also observed that …

Micrornas Are Enriched At Covid-19 Genomic Risk Regions, And Their Blood Levels Correlate With The Covid-19 Prognosis Of Cancer Patients Infected By Sars-Cov-2, Simone Anfossi, Faezeh Darbaniyan, Joseph Quinlan, Steliana Calin, Masayoshi Shimizu, Meng Chen, Paola Rausseo, Michael Winters, Elena Bogatenkova, Kim-Anh Do, Ivan Martinez, Ziyi Li, Loredana Antal, Tudor Rares Olariu, Ignacio Wistuba, George A Calin

Faculty, Staff and Student Publications

Background: Cancer patients are more susceptible to an aggressive course of COVID-19. Developing biomarkers identifying cancer patients at high risk of COVID-19-related death could help determine who needs early clinical intervention. The miRNAs hosted in the genomic regions associated with the risk of aggressive COVID-19 could represent potential biomarkers for clinical outcomes.

Patients and methods: Plasma samples were collected at The University of Texas MD Anderson Cancer Center from cancer patients (N = 128) affected by COVID-19. Serum samples were collected from vaccinated healthy individuals (n = 23) at the Municipal Clinical Emergency Teaching Hospital in Timisoara, Romania. An in …

Racial Variability In Immune Responses Only Partially Explains Differential Systemic Sclerosis Disease Severity, Kamini E Kuchinad, Ji Soo Kim, Adrianne Woods, Gwen Leatherman, Laura Gutierrez-Alamillo, Maureen D Mayes, Robyn Domsic, Paula S Ramos, Richard M Silver, John Varga, Lesley Ann Saketkoo, Suzanne Kafaja, Victoria K Shanmugan, Jessica Gordon, Lorinda Chung, Elana J Bernstein, Pravitt Gourh, Francesco Boin, Daniel L Kastner, Scott L Zeger, Livia Casciola-Rosen, Fredrick M Wigley, Ami A Shah

Faculty, Staff and Student Publications

Objective: To understand if autoantibodies account for racial variation in disease severity, we compared autoantibody distribution and associated phenotype between self-identified black and white systemic sclerosis (SSc) patients.

Methods: 803 black and 2178 white SSc patients had systematic testing for autoantibodies using Euroimmun (centromere (ACA), RNA-polymerase III (POLR3), Scl70, PM/Scl, NOR90, Th/To, Ku, U3RNP and Ro52) and commercial ELISA (U1RNP). In this observational study, logistic regression was performed to assess the association between self-identified race and outcomes, adjusting for autoantibodies. To estimate whether the effect of race was mediated by autoantibody status, race coefficients from multivariate models including and excluding …

October 21, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Impaired Updating Of Working Memory Representations In Individuals With High Bmi: Evidence For Dopaminergic Mechanisms, Nadine Herzog, Hendrik Hartmann, Lieneke K. Janssen, Arsene Kanyamibwa, Maria Waltmann, Peter Kovacs, Lorenz Deserno, Sean Fallon, Arno Villringer, Annette Horstmann

School of Psychology

Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory gating mechanism. Prior research indicates that obesity may elevate the risk of working memory deficits, yet the underlying mechanisms remain elusive. Dopaminergic abnormalities have emerged as a potential mediator. However, current models suggest these abnormalities should only shift the balance in working memory tasks, not produce overall deficits. The empirical support for this notion is currently lacking, however. To address this gap, we pooled data from three studies …

Psychological And Social Well-Being Of Bony Fishes In Zoos And Aquariums (Ii), Ronald G. Oldfield

Faculty Scholarship

Research on the behaviour of animals in zoos has been conducted for decades, and observations have provided information that has improved the psychological and social well-being of animals. However, research on fishes in zoos and aquariums seems to be lacking. Here, we assess the current state of research on fishes in zoos and aquariums by surveying the peer-reviewed literature. Our assessment differs from previous surveys in that we examine the taxonomic classes Chondrichthyes (sharks and rays) and Osteichthyes (bony fishes) separately. Our survey finds that bony fishes have been drastically underrepresented in zoo journals, more drastically than chondrichthyans, revealing an …

Parrotfeather (Myriophyllum Aquaticum) Identification And Management In Waterways, Jacob Hadfield, Cody Zesiger, Michael Pace, Mirella Ortiz, Corey Ransom

All Current Publications

Parrotfeather (Myriophyllum aquaticum) is an invasive aquatic plant species that grows in ditches, ponds, lakes, and other freshwater habitats. Due to its aggressive nature, parrotfeather will often take over freshwater settings by creating a thick mat covering that prevents sunlight for native aquatic organisms and inhibits regular water flow. This fact sheet discusses identification and management options.

Anthropology & Aging From The Editor-In-Chief, Manonita Ghosh

Research outputs 2022 to 2026

No abstract provided.

Volume 48-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 48-2 Complete Issue

An All-Hazards Approach To Us Military Base Camp Site Selection, Mark Corson, Christopher Jasperro

The Geographical Bulletin

Throughout history, military forces have built encampments and bases in hostile areas to defend and sustain themselves while on campaign. The predominant criteria for site selection were and continue to be tactical and logistical concerns. This article applies a geographic perspective to US military base camp site selection in contingency operations such as Bosnia, Kosovo, Iraq, or Afghanistan. In particular, it argues that an all-hazards approach should be employed in the site selection process, and that the all-hazards approach be an integral part of the planning phase of base camp development and emerging site selection doctrine. This project begins with …

Volume 48-1 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 48-1 Complete Issue

Environment And Security Conflicts: The U.S. Military In Okinawa, Jonathan Taylor

The Geographical Bulletin

This paper explores the effects of ongoing environmental issues related to U.S. military bases in Okinawa. Okinawa’s history, particularly the damage it suffered during World War II has led to an active anti-military movement on the island. The U.S. bases exist in a context of anti-military and environmental movements which seek to dislodge the bases from their current location. At the same time the U.S. military bases have had both direct and indirect effects upon Okinawa’s environment: some positive, though many negative. Some steps the U.S. military could take to lessen its environmental impacts upon Okinawa are suggested.

Workshop - Sustainability (Training Workshop), Sponsored By Evotec, Sara Badr, Priyanka Gupta

Integrated Continuous Biomanufacturing VI

No abstract provided.

The Rabbit Jumps Ahead - Rapid A Biosmb Biolayer Interferometry Technology, Thomas Kruse, Markus Kampmann, Fabian Schmitz

Integrated Continuous Biomanufacturing VI

Please click Additional Files below to see the full abstract.