Digital Commons Network^™

2024 Conference Program - Integrated Continuous Biomanufacturing Vi (Icb Vi), Ana Azevedo, Aaron Noyes, Kevin Brower

Integrated Continuous Biomanufacturing VI

No abstract provided.

Building The Future Of Icb With Lessons From The Past A Personal Journey In Continuous Bioprocessing, Charles Cooney

Integrated Continuous Biomanufacturing VI

Please click Additional Files below to see the full abstract.

Eco-Design: Alternatives To Process Mass Intensity In Assessing The Impact Of Bioprocessing, Andrew Sinclair, Claire Hill, Yuki Abe, Sa’Ad Ojeilli

Integrated Continuous Biomanufacturing VI

Please click Additional Files below to see the full abstract

Consumer Possessed: A Comment On Assessing Belk’S “Possessions And The Extended Self”, A. Fuat Firat

Marketing Faculty Publications

While outstanding in observing the contemporary experience of being a “consumer” to become a “canonical article” in consumer research, as Thompson deftly analyzes, Belk’s “Possessions and the Extended Self” is subject to varied traps of remaining within the “mainstream marketing’s ideological boat.” This commentary attempts to highlight these ideological traps as we hopefully escape contemporary capitalism’s system of production of consumer subjectivity.

Tunable Blended Collagen I/Ii And Collagen I/Iii Hydrogels As Tissue Mimics, Paulina M. Babiak, Carly M. Battistoni, Leonard Cahya, Rithika Athreya, Jason Minnich Ii, Alyssa Panitch, Julie C. Liu

School of Chemical Engineering Faculty Publications

Collagen (Col) is commonly used as a natural biomaterial for biomedical applications. Although Col I is the most prevalent col type employed, many collagen types work together in vivo to confer function and biological activity. Thus, blending collagen types can better recapitulate many native environments. This work investigates how hydrogel properties can be tuned through blending collagen types (col I/II and col I/III) and by varying polymerization temperatures. Col I/II results in poorly developed fibril networks, which softened the gels, especially at lower polymerization temperatures. Conversely, col I/III hydrogels exhibit well-connected fibril networks with localized areas of fine fibrils and …

Examination Of Musical Sophistication And Working Memory Correlates In High School Students, Abby South

LSU Doctoral Dissertations

Abstract

The purpose of this study was to examine the relationship between musical engagement and cognitive ability in high school students. While musicians’ brains have long been of interest to those who study experience-dependent neuroplasticity, a lack of adolescent data grossly limits our understanding of the relationship between music training and observed neuroplastic changes in the brain. Advances in psychometric testing and brain imaging reveal relationships among musical expertise, changes in brain function, structure, and connectivity, and enhanced cognitive ability, but categorical groupings of dichotomously defined musicians and non-musicians prevent nuanced understanding of these complex relationships. In this study, 83 …

Perioperative Chemoimmunotherapy Induces Strong Immune Responses And Long-Term Survival In Patients With Hla Class I-Deficient Non-Small Cell Lung Cancer, Marta Molina-Alejandre, Francisco Perea, Virginia Calvo, Cristina Martinez-Toledo, Ernest Nadal, Belén Sierra-Rodero, Marta Casarrubios, Joaquín Casal-Rubio, Alex Martinez-Martí, Amelia Insa, Bartomeu Massuti, Santiago Viteri, Isidoro Barneto Aranda, Delvys Rodriguez-Abreu, Javier De Castro, Joaquín Mosquera Martínez, Manuel Cobo, Ignacio I Wistuba, Edwin R Parra, Javier Martín-López, Diego Megías, Rafael Muñoz-Viana, Federico Garrido, Natalia Aptsiauri, Francisco Ruiz-Cabello, Mariano Provencio, Alberto Cruz-Bermúdez

Faculty, Staff and Student Publications

BACKGROUND: Loss of human leukocyte antigen (HLA) class I expression and loss of heterozygosity (LOH) are common events implicated in the primary resistance of non-small cell lung cancer (NSCLC) to immunotherapy. However, there is no data on perioperative chemoimmunotherapy (ChIO) efficacy or response mechanisms in the context of HLA class I defects.

METHODS: Baseline HLA class I tumor status (HLA-deficient (HLA-DEF) or HLA-proficient (HLA-PRO)) was determined by DNA LOH combined with immunohistochemistry for protein levels in tissue of 24 patients with NSCLC treated with perioperative nivolumab plus chemotherapy from NADIM trial (NCT03081689). We integrated HLA tumor status with molecular data …

Construction Of Almost Unbiased Estimator For Population Mean Using Neutrosophic Information, Rajesh Singh, Anamika Kumari, Florentin Smarandache, Shobh Nath Tiwari

Neutrosophic Sets and Systems

In classical statistics, the population mean is estimated using determinate, crisp data value when auxiliary information is known. These estimates can often be biased. The main objective of this study is to introduce the neutrosophic estimator with the minimum mean squared error (MSE) for the unknown value of the population mean as well as overcome the limitations of classical statistics when dealing with ambiguous or indeterminate data. Neutrosophic statistics was introduced by Florentin Smarandache. It is a generalisation of classical statistics that addresses ambiguous, unclear, vague, and indeterminate data. In this study, we have proposed neutrosophic almost unbiased estimator that …

Natural Bee Space And Comb Cell Dimensions Of Honey Bee Colonies In Mwinkantsi Village, Babati District, Tanzania, Theobald J Theobald, Richard A Kidabaga, Shibonage K Mashilingi

Tanzania Journal of Science

The use of improved beehives in beekeeping is emphasized to facilitate easier colony manipulations. The improved beehives used in Tanzania are either imported or manufactured locally by adopting dimensions for European honey bees. However, the dimensions adopted are faulty to the dimensions of local honey bees, leading to problems such as cross-combing which hinder realization of the expected management advantages. This study assessed the characteristic natural bee space and comb cell dimensions of honey bee colonies occupied the traditional split log hives in Mwinkantsi village, Babati district. Results showed that honey bee colonies in Mwinkantsi village exhibited an overall bee …

Focused On Chinese Life Science Research For 96 Years, Anchoring The Goal Of Scientific And Technological Power To Make New Contributions, Gexia Qiao

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Institute of Zoology (IOZ) is one of the oldest scientific research institutions of Chinese Academy of Sciences (CAS). During its prominent 96-years history, IOZ always serves national strategy and pursues the forefront of science. IOZ has made significant contributions to the discipline development of zoology even life science in China. The major zoological research systems in China are built based on IOZ, as well as several sub-disciplines of zoology and life science in China are derived and flourished from IOZ. IOZ made many critical achievements, including national natural resource investigation, nature reserve establishment, pest insect and rodent management, conservation …

Basic Research: Understanding Leads To Innovation—Exploring Path Of Development Of Center For Excellence In Molecular Plant Sciences, Chinese Academy Of Sciences, Yu Zhang, Zhengxing Yang, Hong Ju, Bin Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

This study summarizes the development path of the Center for Excellence in Molecular Plant Sciences (CEMPS), Chinese Academy of Sciences (CAS), including the developmental trajectories of disciplines and the institutional reform at specific historical opportunities. It also overviews the CEMPS’s strategic orientation (setting sights on the global frontiers of science and technology and the major needs of the country), the scientific achievements, and the core spirits of scientists, thus to provide references to the reform, innovation, and development of scientific research institutions in relevant fields.

"Traditionalizing" Effect Of Parenthood On First Time Mothers: Insights From A Longitudinal Study, Vilma Ražauskienė

The Qualitative Report

Researchers have documented that transitioning to parenthood may have a "traditionalizing“ effect on the gendered division of housework and childcare. The goal of this research is to enhance an understanding of the factors that influence this change in behaviour and attitudes swaying it to the side of traditional gender roles. To achieve this objective, two waves of individual semi-structured interviews were conducted with ten women during pregnancy and four to six months postpartum. Although convenience sampling was employed for data collection, the research participants displayed variation in terms of marital status, educational level, number of children, breastfeeding practices, and other …

Ecological View And Practice Of Chinese Path To Modernization, Yue Shi, Jiangling Zhu, Jingyun Fang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Chinese path to modernization is characterized by emphasizing the harmony between humanity and nature. It upholds the principles of respecting, obeying, and protecting nature to achieve a coordinated integration of economic development and ecological conservation. This ecological view stems from China’s modernization practices, aligns with universal principles of modernization, and roots in features that are unique to China. It stresses a correct understanding of the human–nature relationship, the importance of systematic ecological planning and the central role of ecosystems in ecological conservation, and the necessity of following the laws of nature. Drawing on the experiences and lessons from Western …

Upholding “Triple Real” Vision For Ocean Negative Carbon Emissions To Advance Global Climate Governance, Nianzhi Jiao, Chuanlun Zhang, Tingwei Luo, Jihua Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Addressing climate change is a formidable challenge for humanity, and achieving the temperature control goals of the Paris Agreement cannot rely solely on greenhouse gas emission reductions—negative emissions are an inevitable solution. The ocean, as the planet’s largest active carbon reservoir, holds immense potential for negative emissions, yet there is no internationally recognized pathway to realize it. The UNESCO-IOC international program of Ocean Negative Carbon Emissions (ONCE) builds on the original theory of the microbial carbon pump (MCP) and integrates known ocean carbon sequestration mechanisms BCMS (standing for biological carbon pump, carbonate counter pump, MCP, solubility carbon pump) to propose …

Joint Subarray Acoustic Tweezers Enable Controllable Cell Translation, Rotation, And Deformation, Liang Shen, Zhenhua Tian, Kaichun Yang, Joseph Rich, Jianping Xia, Neil Upreti, Jinxin Zhang, Chuyi Chen, Nanjing Hao, Zhichao Pei, Tony Jun Huang

Faculty Publications

Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the six fundamental motions (three translational and three rotational motions). This study presents a joint subarray acoustic tweezers platform that leverages acoustic radiation force and viscous torque to control the six fundamental motions of single bioparticles. This breakthrough is significant as our manipulation mechanism allows for controlling the three translational and three rotational motions of single cells, as well as enabling complex manipulation that combines controlled translational and rotational motions. …

Nitrogen Isotope Homogenization Of Dissolved Ammonium With Depth And 15N Enrichment Of Ammonium During Incorporation Into Expandable Layer Silicates In Organic-Rich Marine Sediment From Guaymas Basin, Gulf Of California, Toshiro Yamanaka, Arisa Sakamoto, Kanon Kiyokawa, Jaeguk Jo, Yuji Onishi, Yoshihiro Kuwahara, Ji Hoon Kim, Lucie C. Pastor, Andreas Teske, Daniel Lizarralde, Tobias W. Höfig, Ivano W. Aiello, Jeanine L. Ash, Diana P. Bojanova, Martine D. Buatier, Virginia P. Edgcomb, Christophe Y. Galerne, Swanne Gontharet, Verena B. Heuer

Faculty Research, Scholarly, and Creative Activity

Sedimentary nitrogen isotopic ratios are used as a proxy for ancient biogeochemical cycles on Earth's surface. It is generally accepted that sediment hole tops record primary signatures because organic nitrogen (ON) is predominant in this part of the hole. In contrast to such early to middle diagenetic stages, it is well known that heavier nitrogen isotope 15N tends to enrich in sedimentary rocks during later diagenetic and metamorphic stages. However, there are some critical gaps in our understanding of nitrogen isotopic alteration associated with abiotic processes during early-middle diagenesis. In this study, we examined the isotope ratios of ammonium nitrogen …

Editorial: Exploring The Potential Of Nanobiomaterials In Biomedical Engineering: Assessing Biocompatibility, Toxicity, And Future Prospects, Narsimha Mamidi, Ebrahim Mostafavi, Murali M. Yallapu

School of Medicine Publications

No abstract provided.

Factors Influencing The Faunal Recolonization Of Restored Thornscrub Forest Habitats, Audrey J. Hicks, Jerald T. Garrett, Christopher A. Gabler

School of Earth, Environmental, & Marine Sciences Faculty Publications

Tamaulipan thornscrub forests (thornforests) have high ecological and economic values, yet over 90% of these forests have been lost, and they remain threatened, making them a conservation hotspot. For decades, federal, state, NGO, and corporate entities have been acquiring land and actively or passively restoring these forests, but results have been mixed and seldom monitored. This study characterized and quantified faunal communities of restored thornforest habitats in south Texas and examined the relationships between restored faunal communities and key site characteristics and environmental factors. We surveyed and analyzed mammal, bird, Lepidoptera, and herptile communities within 12 restored sites in the …

Volume 49-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 49-2 Complete Issue

Spring Valley, Washington Dc: Changing Land Use And Demographics From 1900-2000, Benefsheh D. Verell

The Geographical Bulletin

Spring Valley, located in northwest Washington D.C., has had a dynamic land use history, changing from farmland to military base to residential development during the span of one hundred years. The development and marketing of Spring Valley in the 1930s and 1940s reflects the changing socioeconomics and settlement patterns of D.C. The data suggest a “white flight” out of the inner-city neighborhoods to Spring Valley and the surrounding suburbs. Additionally, Spring Valley, as a Formerly Used Defense Site, presents environmental hazards to the current residential community. The Army’s response to this hazard demonstrates changes in military environmental policies from nonexistent …

Remote Sensing Quantification Of Wetland Habitat Change In South Carolina: Implications For Coastal Resource Policy, John All, Jenna Nelson

The Geographical Bulletin

Increased urbanization of coastal areas has resulted in the pollution and destruction of wetland ecosystems worldwide. The effect of development on local wetland habitat was examined for Mount Pleasant, South Carolina, USA. Changes in the areal extent of wetlands in Mount Pleasant were determined through a quantification of changes in wetland margins from the 1970s to 1990s using Landsat data. The rate of wetland habitat loss accelerated from the 1980s to 1990s compared to the 1970s, even though coastal zone regulations had been strengthened and the rate of population increase was comparable for the decades selected for comparison. This paper …

Assessing A Small Summer Urban Heat Island In Rural South Central Pennsylvania, Danielle Doyle, Timothy W. Hawkins

The Geographical Bulletin

The development of cities potentially has a significant impact on climate. Buildings and infrastructure that replace natural vegetation often create new microclimates through changes in the energy balance associated with the built environment. The urban heat island effect, the phenomenon where air temperatures within an urban area are warmer than the surrounding rural areas, has been thoroughly examined for large urban areas. The purpose of this study is to determine the magnitude and extent of the urban heat island for a small urban area surrounded by agricultural land. Temperature data collected from several urban and rural locations over a four-month …

Review Of Current Trends In Information Technology Concerning Phonetic Similarity”, Zaid Rajih Mohammed, Ahmed H. Aliwy

Al-Bahir

With the increasing availability of textual information in various languages via the Internet in homes and companies through Internet and intranet services, there is an urgent need for the technologies and tools necessary to process this information, phonetic representation, and voice interaction. For example voice to voice machine translation need to phonetic mapping and similarity among the languages especially for names and foreign words. This one example of the importance of phonetic mapping and similarity. This article aims to describe, in detail, the recent surge in interest and advancements in phonetic similarity (PS), phonetic representation, and phonetic mapping researches. PS …

Mutation In Prkra Results In Cerebellar Abnormality And Reduced Elf2Α Phosphorylation In A Model Of Dyt-Prkra, Samuel B. Burnett, Allison M. Culver, Tricia A. Simon, Taylor Rowson, Kenneth Frederick, Kristina Palmer, Stephen A. Murray, Shannon W. Davis

Faculty Publications

Variants in the PRKRA gene, which encodes PACT, cause the early-onset primary dystonia DYT-PRKRA, a movement disorder associated with disruption of coordinated muscle movements. PACT and its murine homolog RAX activate protein kinase R (PKR; also known as EIF2AK2) by a direct interaction in response to cellular stressors to mediate phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Mice homozygous for a naturally arisen, recessively inherited frameshift mutation, Prkra^lear-5J, exhibit progressive dystonia. In the present study, we investigated the biochemical and developmental consequences of the Prkra^lear-5J mutation. Our results indicated that the …

The Giab Genomic Stratifications Resource For Human Reference Genomes, Nathan Dwarshuis, Divya Kalra, Jennifer Mcdaniel, Philippe Sanio, Pilar Alvarez Jerez, Bharati Jadhav, Wenyu Eddy Huang, Rajarshi Mondal, Ben Busby, Nathan D Olson, Fritz J Sedlazeck, Justin Wagner, Sina Majidian, Justin M Zook

Faculty, Staff and Students Publications

Despite the growing variety of sequencing and variant-calling tools, no workflow performs equally well across the entire human genome. Understanding context-dependent performance is critical for enabling researchers, clinicians, and developers to make informed tradeoffs when selecting sequencing hardware and software. Here we describe a set of “stratifications,” which are BED files that define distinct contexts throughout the genome. We define these for GRCh37/38 as well as the new T2T-CHM13 reference, adding many new hard-to-sequence regions which are critical for understanding performance as the field progresses. Specifically, we highlight the increase in hard-to-map and GC-rich stratifications in CHM13 relative to the …

The Role Of Peptides In Combatting Hiv Infection: Applications And Insights, Naiera M. Helmy, Keykavous Parang

Pharmacy Faculty Articles and Research

Peptide-based inhibitors represent a promising approach for the treatment of HIV-1, offering a range of potential advantages, including specificity, low toxicity, and the ability to target various stages of the viral lifecycle. This review outlines the current state of research on peptide-based anti-HIV therapies, highlighting key advancements and identifying future research directions. Over the past few years, there has been significant progress in developing synthetic peptide-based drugs that target various stages of the viral life cycle, including entry and replication. These approaches aim to create effective anti-HIV therapies. Additionally, peptides have proven valuable in the development of anti-HIV vaccines. In …

Adverse Childhood Experiences Moderate The Association Between Sensory Processing Sensitivity And Depression, Grant Benham

Psychological Science Faculty Publications

Investigations of the link between personality and depression provide a path to identifying at-risk individuals and developing tailored treatment. Sensory processing sensitivity, reflecting individual differences in processing of internal and external stimuli, has been found to predict depression severity. Based on a diathesis-stress model, the present study examines whether this association is moderated by adverse childhood experiences. An online survey containing standardized measures of adverse childhood experiences, sensory processing sensitivity, and depression severity, was administered to 558 college students. The sample was predominantly Hispanic (92%) and female (70%) with a mean age of 20.2 years. In support of the diathesis-stress …

Nesting Of An Alien Invasive House Crow Corvus Splendens In Verges Along Arterial Roads In Dar Es Salaam, Tanzania, Jasson R. John

Tanzania Journal of Science

In most cities where little of the original natural vegetation remains, road verges act as home to many urban wildlife. However, the use of road verges for alien avifauna such as House Crow (Corvus splendens) has not been fully documented. This study, conducted between June and July 2021 investigated nesting preferences of the House Crow with particular regards to different verge subdivisions of arterial roads and tree species in Dar es Salaam, Tanzania. Nests were searched in 1813 trees (=42 species) along a stretch of 20 km, and 159 trees (=15 species) were nested with C. splendens. Overall, a total …

Policy-Relevant Differences Between Secondhand And Thirdhand Smoke: Strengthening Protections From Involuntary Exposure To Tobacco Smoke Pollutants, Georg E Matt, Lydia Greiner, Rachael A Record, Heather Wipfli, Jamie Long, Nathan G Dodder, Eunha Hoh, Nicolas Lopez Galvez, Thomas E Novotny, Penelope J E Quintana, Hugo Destaillats, Xiaochen Tang, Antoine M Snijders, Jian-Hua Mao, Bo Hang, Suzaynn Schick, Peyton Jacob, Prue Talbot, E Melinda Mahabee-Gittens, Ashley L Merianos, Thomas F Northrup, Lara Gundel, Neal L Benowitz

Faculty, Staff and Student Publications

Starting in the 1970s, individuals, businesses and the public have increasingly benefited from policies prohibiting smoking indoors, saving thousands of lives and billions of dollars in healthcare expenditures. Smokefree policies to protect against secondhand smoke exposure, however, do not fully protect the public from the persistent and toxic chemical residues from tobacco smoke (also known as thirdhand smoke) that linger in indoor environments for years after smoking stops. Nor do these policies address the economic costs that individuals, businesses and the public bear in their attempts to remediate this toxic residue. We discuss policy-relevant differences between secondhand smoke and thirdhand …

Excess Potassium Promotes Autophagy To Maintain The Immunosuppressive Capacity Of Myeloid-Derived Suppressor Cells Independent Of Arginase 1, Ramesh Thylur Puttalingaiah, Matthew J. Dean, Liqin Zheng, Phaethon Philbrook, Dorota Wyczechowska, Timothy Kayes, Luis Del Valle, Denise Danos, Maria Dulfary Sanchez-Pino

School of Medicine Faculty Publications

Potassium ions (K+) are critical electrolytes that regulate multiple functions in immune cells. Recent studies have shown that the elevated concentration of extracellular potassium in the tumor interstitial fluid limits T cell effector function and suppresses the anti-tumor capacity of tumor-associated macrophages (TAMs). The effect of excess potassium on the biology of myeloid-derived suppressor cells (MDSCs), another important immune cell component of the tumor microenvironment (TME), is unknown. Here, we present data showing that increased concentrations of potassium chloride (KCl), as the source of K+ ions, facilitate autophagy by increasing the expression of the autophagosome marker LC3β. Simultaneously, excess potassium …