Digital Commons Network^™

Hematopoietic Cell Transplant Compared With Standard Care In Adolescents And Young Adults With Sickle Cell Disease, Mark C. Walters, Mary Eapen, Yiwen Liu, Fuad El Rassi, Edmund K. Waller, John E. Levine, John J. Strouse, Joseph H. Antin, Suhag H. Parikh, Nitya Bakshi, Carlton D Dampier, Jennifer J. Jaroscak, Shayla Bergmann, Trish E. Wong, Vamsi K. Kota, Betty Sue Pace, Lazaros J. Lekakis, Premal D. Lulla, Robert Nickel, Kimberly A. Kasow, Uday R. Popat, Wally R. Smith, Lolie C. Yu, Nancy L. Difronzo, Nancy L. Geller, Naynesh Kamani, Elizabeth Sue Klings, Kathryn Hassell, Adam M. Mendizabal, Et Al

School of Medicine Faculty Publications

Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2-years after biologic assignment to a Donor or No Donor (SOC) Arm based on the availability of an HLA-matched sibling or unrelated donor (BMTCTN 1503; NCT02766465). A donor search was commenced after eligibility confirmation. The primary endpoint was the comparison of survival 2 years after biologic assignment between treatment arms. Power calculations required 60 participants on the Donor Arm and 140 on the No Donor Arm to determine if early transplant-related mortality might be balanced …

Child Risk For Obesity And Physical Activity, Bethany Moore

All ETDs from UAB

Childhood obesity is a significant health problem in the United States with consequences presenting themselves in the short- and long-term. Physical activity is a modifiable factor associated with adiposity and can at least partially attenuate the consequences of childhood obesity. There are many factors which influence children’s participation in regular physical activity, some of which are also associated with pediatric obesity. The overarching purpose of this research is to investigate potential influences on the association of obesity and physical activity among typically developing children. Aim 1 used a secondary analysis of n=163 children to explore independent and interactive effects of …

Oyster Grower Perspectives On Green Crab (Carcinus Maenas) Interactions: Using Applied Social Science To Inform Research And Engagement, Kelsey Meyer-Rust, Lindsey Williams, Krystin Ward, Bonnie Brown

Faculty Publications

Research that informs the New Hampshire Aquaculture industry, which has grown significantly over the past few years, and helps the overall associated watershed community to keep Great Bay Estuary healthy is vital. Specific study of green crabs, Carcinus maenas, and their potential effects on oysters, Crassostrea virginica, is important to gain a better understanding of the impact invasive species may have on these ecologically and economically important bivalves. The aim of this study was to document and understand New Hampshire (NH) oyster growers’ perspectives on the issue of green crab predation of oysters. Through a survey, this study documented a …

The Lived Experience Of Psychological Suffering In Animal/Environmental Activists, Pamela Jimenez

Walden Dissertations and Doctoral Studies

Animal agriculture, the second-largest contributor to climate change, poses serious risks to human and global health. Animal/environmental activists work to reduce these risks but often face verbal ridicule and physical violence; however, little is known about the psychological suffering experienced by this group. This interpretative phenomenological analysis (IPA) aimed to explore the experience of psychological suffering in animal/environmental activists committed to ending exploitative animal agriculture and environmental activities. Ecopsychological theory and psychological constructs, such as eco-anxiety, eco-grief, and vicarious trauma, comprised the conceptual framework for this study. Data were collected through semistructured interviews with 18 animal/environmental activists, incorporating participant-selected photographs …

Relationship Between Depression And Stress On Accessing Recovery Capital Among Individuals With Opioid Use Disorder, Deana Luciano

Walden Dissertations and Doctoral Studies

This study addresses the critical need to understand how mental health challenges and external stressors affect long-term recovery from an Opioid Use Disorder (OUD). Grounded in the Recovery Capital Framework, this study analyzed the relationship between depression, stressful life events, and recovery capital (RC) among individuals in recovery from severe OUD. Utilizing a quantitative nonexperimental survey design, data were collected from a purposive sample of 107 adults aged 18 and older who had been in recovery for at least 2 years. Participants completed surveys assessing depression, life stressors, and their RC through established instruments including the Zung Self-Rating Depression Scale, …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Dynamic Dysregulation Of Retrotransposons In Neurodegenerative Diseases At The Single-Cell Level\, Wankun Deng, Citu Citu, Andi Liu, Zhongming Zhao

Faculty, Staff and Student Publications

Retrotransposable elements (RTEs) are common mobile genetic elements comprising ∼42% of the human genome. RTEs play critical roles in gene regulation and function, but how they are specifically involved in complex diseases is largely unknown. Here, we investigate the cellular heterogeneity of RTEs using 12 single-cell transcriptome profiles covering three neurodegenerative diseases, Alzheimer's disease (AD), Parkinson's disease, and multiple sclerosis. We identify cell type marker RTEs in neurons, astrocytes, oligodendrocytes, and oligodendrocyte precursor cells that are related to these diseases. The differential expression analysis reveals the landscape of dysregulated RTE expression, especially L1s, in excitatory neurons of multiple neurodegenerative diseases. …

The George-Anne, Georgia Southern University

The George-Anne

• Hoco Recap
• Hurricane Helene greatly impacts Statesboro
• Hidden Gems: Galactic Comics
• Hidden Gems: Gators & Gypsies
• Hidden Gems: The Sweet Impact
• Clock Ticking: the Vault Apartment Building Could Be Condemned Residents Forced to Relocate
• EXCLUSIVE: President Marrero Addresses Georgia Southern's Latest National Achievement
• I Won't Accept "It's Just Another Day As A Teacher" As My Answer To Any Dangerous Situation At School
• Petsboro
• The George-Anne Coloring Page

The Future Of Transcranial Ultrasound As A Precision Brain Interface, Keith Murphy, Elsa Fouragnan

School of Psychology

Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene and restore them. Developing technologies that can precisely interface with any brain region and circuit may combine diagnostics with therapeutic intervention, expediting personalised brain medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution to this challenge, offering focal precision and scalability. By exploiting the biomechanics of pressure waves on brain tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in the cortex and deeper areas alike. In this Essay, we explore the emergent evidence that TUS can functionally test and modify dysfunctional regions, effectively …

Zoographics In The Journal Of The Experimental Analysis Of Behavior: Increasing Inclusion Of Female Animals, Amy L. Odum, Kiernan T. Callister, Mariah E. Willis-Moore, Daniel S. Da Silva, David N. Legaspi, Lucy N. Scribner, Josephine N. Hannah

Psychology Faculty Publications

We examined the zoographics, or the characteristics of nonhuman animal subjects, reported for the entirety of the Journal of the Experimental Analysis of Behavior (JEAB) through the most recent complete year (1958–2023). Animal sex in particular was evaluated to determine whether the lack of inclusion of female subjects in other disciplines extends to JEAB. Through systematic coding of all nonhuman empirical articles, we found consistent underreporting of most zoographics and a disproportionate use of male subjects relative to female subjects. Additionally, animal sex was commonly unreported and the inclusion of both male and female subjects was sparse. …

Assessing The Effects Of Dasatinib On Mesenchymal Stem/Stromal Cells, David P. Heinrichs, Vitali Maldonado, I Kade Karisma Gita Ardana, Ryan M. Porter, Rebekah M. Samsonraj

Biomedical Engineering Faculty Publications and Presentations

Introduction

Progressive aging, or senescence, of mesenchymal stem/stromal cells (MSCs) is a major obstacle faced when trying to culture potent stem cells for use in therapy. Senescent cells are irreversibly nondividing cells that cease performing critical functional effects. Elimination of senescent cells using biochemical means, such as the use of senolytic drugs like dasatinib, may be useful in retaining the viable and proliferating populations of the cells.

Methods

An in vitro approach was used to investigate the effect of dasatinib on phenotypic, genotypic, and immunomodulatory functionality of osteogenic and adipogenic differentiated MSCs. Replicative senescence was achieved through multiple sub-culturing in …

A Stronger Impact On Career Development For Early- And Mid-Career Faculty, Daniel A Gorelick, Jason Gertz, Kaitlin J Basham, Lindsey S Treviño

Faculty, Staff and Students Publications

Nuclear receptors are important in normal physiology and disease. Physicians and scientists who study nuclear receptors organize and attend conferences and symposia devoted to foundational and translational nuclear receptor research, but the field lacks a platform for early-stage investigators and aspiring leaders. In 2019, Zeynep Madak-Erdogan, Rebecca Riggins, and Matthew Sikora founded Nuclear Receptor (NR) Interdisciplinary Meeting for Progress And Collaboration Together (IMPACT, https://nrimpact.com), a collaborative group designed for early- and mid-career faculty who study nuclear receptors in any context or organism [1]. NR IMPACT addresses challenges for early- and mid-career faculty. Here, we review the progress of NR IMPACT …

Mutational Scanning Of Crx Classifies Clinical Variants And Reveals Biochemical Properties Of The Transcriptional Effector Domain, James L Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, Barak A Cohen

2020-Current year OA Pubs

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human

Evaluating Uv-Protective Low-Emissivity Window Films: Implications For Thermal And Visual Comfort In Luminous Office Buildings, Lina M. Shaker

AUIQ Complementary Biological System

This review article explores the integration of thin window films and solar energy systems to enhance thermal comfort in luminous office buildings. Luminous office buildings, which prioritize natural lighting, often face challenges in maintaining thermal comfort for occupants. By integrating solar energy systems, such as photovoltaic (PV) and solar thermal systems, with thin window films, it is possible to optimize thermal comfort while harnessing sustainable energy sources. Thin window films act as a barrier against solar radiation, reducing heat gain while allowing therapeutic blue light (400-520nm) transmission. The advantages of thin window films include improved thermal insulation, glare reduction, and …

Coadministration Of Ketamine And Magnesium: An Integrative Review, Lauren Chiavetta

Group: Bryan College of Health Sciences Doctor of Nurse Anesthesia Practice (DNAP) Collection

Objective: The object of this integrative review was to investigate the analgesic benefit and side effect profile of the coadministration of ketamine and magnesium. Secondary goals were to provide an evidence-based recommendation on the ideal dosing, frequency, and order of administration of the medications. Methods: Relevant articles published between January 2001 and May 2019 were examined for quality, strength, and generalizability. Results: Beginning evidence suggests ketamine may interact with magnesium to provide synergistic NMDA receptor antagonism and analgesia. Evidence from animal studies proposes that order of administration may influence potency, with ketamine prior to magnesium producing better analgesia. Coadministration of …

Anesthetic Management Of Mast Cell Activation Syndrome: A Journal Course Review, Candace Glasgow

Group: Bryan College of Health Sciences Doctor of Nurse Anesthesia Practice (DNAP) Collection

Mast cell activation syndrome (MCAS) is a disorder that has only gained recognition in the past twelve years. Patients that are diagnosed with MCAS are plagued with abnormal acute and/or chronic mild to severe (anaphylaxis) mast cell activation (MCA) symptoms that affect two of four organ systems. Abnormal MCA has varying pathophysiology and is categorized as primary, secondary, or idiopathic. While similar in outcome, the prevention of MCA and medical management will vary by the subset of MCAS. This journal course reviews the pathophysiology behind MCAS and MCA. Different subclasses and treatment options of MCAS are clarified. Lastly, the anesthetic …

The Use Of Thromboelastograpy Guided Transfusion Therapy In Trauma: An Integrative Review, Heidi M. Farnum

Group: Bryan College of Health Sciences Doctor of Nurse Anesthesia Practice (DNAP) Collection

Trauma induced mortality can often be attributed to hemorrhage in the early phase of trauma. Up to one-half of trauma deaths are due to uncontrolled bleeding within the first few hours of injury. Patient survival following a traumatic injury is reliant upon the trauma team's ability to gain early control of bleeding. Ways in which the trauma team can gain control of bleeding include rapid identification of the source of hemorrhage, applying direct pressure to the source of hemorrhage, and aggressive resuscitation. Resuscitation efforts are focused on restoring normal physiology and oxygen delivery to tissues. Resuscitation involves the use of …

Incorporating Dexamethasone With Local Anesthetics In Single-Shot Nerve Blocks: An Integrative Review, Kyle G. Hilsabeck

Group: Bryan College of Health Sciences Doctor of Nurse Anesthesia Practice (DNAP) Collection

Prolonging the duration of analgesia in single-shot nerve blocks (SNBs) continues to be a problem in regional anesthesia. Both IV and perineural dexamethasone have proven to be effective in prolonging the duration of analgesia in SNBs.

Objective: The purpose of this integrative review was to determine how IV and perineural dexamethasone effect duration of analgesia, pain scores, opioid consumption, and complications in patients undergoing SNB.

Methods: An integrative review that included 12 peer-reviewed randomized-controlled trials (RCTs) and one meta-analysis was performed.

Results: The results of the integrative review found that perineural dexamethasone prolonged the duration of analgesia, reduced pain scores, …

The Effects Of Preoperative Carbohydrate Loading On Postoperative Nausea And Vomiting: An Integrative Review, Jennifer Meyer

Group: Bryan College of Health Sciences Doctor of Nurse Anesthesia Practice (DNAP) Collection

Background: Postoperative nausea and vomiting (PONV) is a very common problem among surgical patients. Despite improved methods of risk identification, the incidence of PONV remains as high as 20-40%. It can increase hospital length of stay and greatly reduce patient satisfaction. The purpose of this integrative review is to examine the effects of both oral and IV preoperative carbohydrate loading on the incidence of postoperative nausea and vomiting in surgical patients. Methods: A review the literature was completed by searching for the terms related to preoperative carbohydrate loading and PONV. Results: Twenty studies met the criteria and were analyzed for …

Iv Ketamine Infusions For The Treatment Of Depression: An Evidence Based Practice Analysis, Sergio A. Quinones

Group: Bryan College of Health Sciences Doctor of Nurse Anesthesia Practice (DNAP) Collection

According to the World Health Organization, major depressive disorder (MDD) is a mental health condition which affects a significant portion of the worldwide population and is projected to become the leading cause of disability by 2020. There are several treatment options for the diagnosis of depression, with the most popular being antidepressant drugs such as the selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs); and electroconvulsive therapy (ECT). The significant drawbacks to the current treatments are the extended timeframe required for drugs to reach therapeutic efficacy and resistance to ECT over time. These disadvantages can lead to increased risk …

Efficacy Of Chlorhexidine Versus Listerine Perioperative Mouthwash In Preventing Ventilator-Acquired Pneumonia: An Integrative Review, James Owen Clements

Group: Bryan College of Health Sciences Doctor of Nurse Anesthesia Practice (DNAP) Collection

Objective: To compare the safety and efficacy of chlorhexidine versus Listerine in perioperative and intensive care settings in preventing ventilator-acquired pneumonia (VAP).

Methods: An integrative review using a keyword search was conducted in Cochrane, Cinahl, and Google Scholar databases. Data was collected regarding the efficacy of chlorhexidine and Listerine in preventing ventilator-acquired pneumonia, safety and side effect profiles, and in vivoin vitro secondary outcome measures.

Results: Chlorhexidine demonstrates superiority to Listerine in reducing ventilator-acquired pneumonia. Secondary in vivo tests including plaque and gingivitis reduction, and in vitro tests measuring the effect on bacterial loads, also favors chlorhexidine over Listerine. …

Multi-Site Research Playbook: A Practical Guide To Support Multi-Site Research Studies For Greater Impact, Maria Shirey, Jen Bonamer, Sean Clarke, Sheila Haas, Catherine Ivory, Simon Kitto, David Price, Marianne Weiss, Olga Yakusheva, Kathy Chappell, Meg Johantgen

Group: American Nurses Credentialing Center (ANCC)

Rigorous, high-quality nursing research creates an evidence base that advances nursing practice, shapes health policy, and contributes to improving nurse, patient, and system outcomes. Yet, too often, nurse researchers conduct studies that are narrow in scope, underpowered, or lack elements such as a comparison group, thereby limiting generalizability of results and application in practice. Multi-site studies offer the opportunity to increase the rigor of research and the generalizability of findings.

Multi-site studies leverage the power of Magnet® and other research-engaged nursing organizations to conduct research across multiple units and settings. Options for research designs are expanded with larger and more …

Incorporating Ecosystem Information Into The Federal Fisheries Management Process, Adelle Molina

Sustainability Seminar Series

The goal of fisheries management is to maintain sustainable fisheries and preserve their value. Fisheries management councils set fishing rules and regulations based on scientific advice in the form of a stock assessment. Stock assessments collect and analyze data, produce reports on the condition or status of an exploited stock, and estimate sustainable yield. Stock assessment scientists use analytical approaches and quantitative methods to develop stock assessment models that describe the population dynamics of a stock. Traditionally, stock assessments have not accounted for either ecological interactions, such as predation, or the environment. In this presentation, I will briefly describe the …

Decreasing Primary Care Providers' Stigma Of Mental Illness, Nicole Hoogasian

General Submissions: Clinical Settings Materials

A recent study has indicated that primary care providers hold comparable and possibly more negative attitudes towards persons with mental illness than the general public (Mittal et al., 2016b). Because of their regular interactions with patients with mental illness, providers stigmatizing attitudes has been implicated as a primary factor behind healthcare disparities for this population (Flanagan et al., 2016; Lebowitz & Ahn, 2016). Effective interventions at decreasing mental health stigma needs to be researched, evaluated, and implemented in primary care settings (Beaulieu et al., 2017). An analysis of the literature was done to answer the question,"What interventions are effective in …

70% Ethanol For Decontamination Of Central Venous Lines Exposed To Calcineurin Inhibitors, Jessica Ann Copacia, Kimberly Taylor, Melissa Laudick, Rolla Abu-Arja, Jeffery J. Auletta, Hemalatha G. Rangarajan, Amy Pyle-Eilola, Joseph Stanek, Vinta B. Pai, Rajinder Bajwa

General Submissions: Clinical Settings Materials

Tacrolimus, commonly used for GvHD prophylaxis is usually administered via a dedicated CVL and trough levels drawn from the unexposed lumen. Being an oil-based medication, it may be adsorbed to the inside lumen of the CVL and result in falsely high levels drawn from an inadvertently exposed lumen. There is no treatment for decontamination of such CVLs and natural decay occurs over months before the CVL can be used to draw reliable trough levels.

Breathing Techniques Associated With Improved Health Outcomes, Kathleen Benjamin Rickard, Dorothy J. Dunn, Virginia M. Brouch

General Submissions: Clinical Settings Materials

The purpose of this study was to determine if there is evidence to support teaching purposeful breathing techniques to patients for the improvement of health outcomes.

Establishing Therapeutic Relationships, Registered Nurses' Association Of Ontario

General Submissions: Clinical Settings Materials

This nursing best practice guideline will address the therapeutic relationship and its central importance to nursing practice. Effective nursing practice is dependent on an effective therapeutic relationship between the nurse and the client. The guideline addresses the qualities and capacities of an effective therapeutic relationship, the state of knowledge, and the knowledge needed to be effective in a therapeutic relationship. To implement a therapeutic relationship successfully, an organization's characteristics and workplace values must be supportive and in place (see Recommendations 5 to 14). The recommendations in this guideline, therefore, focus on practice, education, organization and policy

The Intensity Of Pain Experienced By Respondents Given Intramuscular (Im) Injection With/Without Skin Tapping Technique, Rita Lakhani, Mini Chacko, Shimon Ghatge, Sharmila Jadhav, Soumya M.K., Supriya Patkar, Vinod Patil

General Submissions: Clinical Settings Materials

A study to evaluate the intensity of pain experienced by respondents given intramuscular (IM) injection with/without skin tapping technique in a selected hospital in Mumbai.

A Qualitative Exploration Of Spiritual Practices Of Simplicity Among Emerging Adults, Falon Opsahl Barton

Discernment: Theology and the Practice of Ministry

This article explores how emerging adults (18 to 29‐year‐olds) integrate pro‐environmental behaviors and spiritual practices of simplicity. First, this article synthesizes the research on emerging adulthood, including what it is, how they experience and express their spirituality, and their emotional and practical behaviors in response to the climate crisis. Then, this article explores how a small sample of Western Protestant emerging adults practice pro‐environmental simplicity in their daily lives. As a result of integrating spiritual practices that focus on simplicity and pro‐environmental behaviors into their spiritual expressions, emerging adults experience profound spiritual formation and a meaningful way of participating in …

Spirituality Of Emerging Adulthood, Falon Opsahl Barton

Discernment: Theology and the Practice of Ministry

This article synthesizes the research on emerging adulthood. After defining the term, this work explores the causes of this phenomenon, the demographic that constitutes it, and how those in this phase of life experience and express their spirituality. Among the significant issues for this demographic are their emotional and practical behaviors in response to the climate crisis.