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Summary Report: 2006 Tiger Summit - Evidence And Informatics Transforming Nursing, Sigma Theta Tau International

Sigma Resource Papers

This report provides the context for the Summit, descriptions of each of the activities over the two days, notes on the participant experience, and photographs of the event, as well as insights and reflections from speakers. The intention of this format is to provide those who did not have an opportunity to attend a high-level understanding of the process that occurred over the two days to achieve the Summit objectives and outcomes. It is not intented to be a comprehensive document such as a white paper. Rather, the content enclosed incorporates descriptive paragraphs and phrases, as well as statements and …

Lower Urinary Tract Symptoms, Depression And Sleep Problems; A Triple Whammy For Patients’ Health-Related Quality Of Life, Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Jeffery David Hughes, Junaid Habib Khan, Yusra Habib Khan, Tauqeer Hussain Mallhi

Bulletin of Faculty of Pharmacy Cairo University

Introduction: Lower urinary tract symptoms (LUTS) are characterized by voiding, storage and post-micturition symptoms. LUTS can have detrimental effects on various facets of patients’ quality of life. Therefore, this study was aimed to evaluate the association of LUTS with depression and sleep disturbances, and their impact on patients’ health-related quality of life (HRQOL).

Methods: A cross-sectional survey was conducted among a clinical sample of calcium channel blocker-users (n = 410), recruited via convenient sampling. Outcomes were assessed using validated Urdu translated instruments [LUTS: International Prostate Symptom Score; sleep problems: Jenkins sleep evaluation questionnaire (JSEQ); depression: Center for Epidemiologic Studies Short …

Photoluminescence Intensity Enhancement And Stability In Cdte/Sio2 Quantum Dots Through Water Molecule Adsorption And Trap Passivation, Daniil S. Daibagya, Ivan A. Zakharchuk, Sergei A. Ambrozevich, Mikhail S. Smirnov, Anna V. Osadchenko, Oleg V. Ovchinnikov, Alexandr S. Selyukov

Karbala International Journal of Modern Science

The study of the luminescence photostability for colloidal nanocrystals is an important task since the understanding of the corresponding physical processes advances new electronic devices based on semiconductor nanoparticles as well as other important applications such as biomarkers. In this paper, we provide the first study and comprehensive analysis of the photostability of the luminescent properties for colloidal CdTe/SiO₂ core/shell quantum dots prepared by an aqueous-based method. The quantum dots were exposed to continuous laser radiation during two time intervals with prolonged break in between. The photoluminescence intensity of the quantum dots increased over time under continuous laser irradiation. …

Removal Of Selenium Ions From Contaminated Aqueous Solutions By Adsorption Using Lemon Peels As A Non-Conventional Medium, Alanood A. Alsarayreh, Suha Anwer Ibrahim, Salem Jawad Alhamd, Thekra Atta Ibrahim, Mohammed Nsaif Abbas

Karbala International Journal of Modern Science

The disposal of heavy metals from various activities has become a pervasive issue. The investigation of sustain-able, low-cost adsorbents for the remediation of these hazardous pollutants has been widely disregarded. This research emphasizes the recovery of selenium ions from contaminated water using lemon peels as a cost-effective adsorbent. The adsorption was explored in a batch unit under various operational parameters, including initial selenium concentration (1-90 ppm), pH (1-11), agitation speed (100-500 rpm), adsorbent dose (0.4-5.5 g), contact time (5-180 minutes), and temperature (25-55 °C). The BET surface area of the lemon peels was found to be 27.86 m²/g before adsorption …

Cannabinoid-Inspired Inhibitors Of The Sars-Cov-2 Coronavirus 2′ -O-Methyltransferase (2′ -O-Mtase) Non-Structural Protein (Nsp10–16), Menny M. Benjamin, George S. Hanna, Cody F. Dickinson, Yeun-Mun Choo, Xiaojuan Wang, Jessica A. Downs-Bowen, Ramyani De, Tamara R. Mcbrayer, Raymond F. Schinazi, Sarah E. Nielson, Joan M. Hevel, Pankaj Pandey, Robert J. Doerksen, Danyelle M. Townsend, Jie Zhang, Zhiwei Ye, Scott Wyer, Lucas Bialousow, Mark T. Hamann

Chemistry and Biochemistry Student Research

The design and synthesis of antiviral compounds were guided by computationally predicted data against highly conserved non-structural proteins (Nsps) of the SARS-CoV-2 coronavirus. Chromenephenylmethanone-1 (CPM-1), a novel biphenylpyran (BPP), was selected from a unique natural product library based on in silico docking scores to coronavirus Nsps with high specificity to the methyltransferase protein (2′ -O-MTase, Nsp10–16), which is responsible for viral mRNA maturation and host innate immune response evasion. To target the 2′ -O-MTase, CPM-1, along with intermediate BPP regioisomers, tetrahydrophenylmethanones (TPMs), were synthesized and structurally validated via nuclear magnetic resonance (NMR) data and DP4+ structure …

Nasa Awards Ud Geologist $340k To Study Sediment Hazards In Andes Glacial Lakes, Dave Larsen

College of Arts and Sciences Newsroom

Umesh Haritashya will study the potential hazard risk to glacier-fed lakes and rivers in South America.

Japan's Response To The Trade Conflict Between The United States And China, Rikako Watai

Washington International Law Journal

Abstract: Decoupling refers to the strategy of separating and disconnecting economies and markets between different nations. However, in the contest of the ongoing trade conflict between the United States and China, decoupling primarily refers to determining economic dependence on a specific nation as a national security risk, thereby reinforcing vulnerabilities in one’s supply chain. Japan views the United States as its primary partner in national security policy and China as a significant market because of its geographic proximity. As a result, ensuring economic security became a pressing concern for Japan.

Japan refers to the United States’ idea of economic …

University Of Northern Iowa Faculty Senate Meeting Minutes, October 28, 2024, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting minutes from the Faculty Senate of the University of Northern Iowa.

Intouch Week Of October 28, 2024, New York Medical College

InTouch

• Medical Students Run for Charity at the 2024 TCS New York City Marathon
• NYMC Goes Pink for Breast Cancer Awareness Month
• Furry Friends Bring Comfort to the College
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC
• Student Spotlight: AMA Foundation Physicians of Tomorrow Scholarship Recipient

The Role Of Cybersecurity In Bioinformatics For Aviation And Aerospace Safety, Sharon L. Burton

Publications

The intersection of bioinformatics and cybersecurity is critical to ensuring the privacy, integrity, and safety of biological data [1]. Bioinformatics is an interdisciplinary field that embodies the cyber age through its reliance on sophisticated algorithms, cloud computing, and secure data management practices, reflecting the profound digital transformation across various scientific disciplines [2].

Platinum Nanoparticle-Based Collision Electrochemistry For Rapid Detection Of Breast Cancer Mcf-7 Cells, Fu-Xing Qin, Ming-Ke Li, Hui-Long Zhou, Wei Wen, Xiu-Hua Zhang, Sheng-Fu Wang, Zhen Wu

Journal of Electrochemistry

Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer. Circulating tumor cells (CTCs) play a pivotal role in cancer metastasis. However, the content of CTCs in peripheral blood is minimal, so the detection of CTCs in real samples is extremely challenging. Therefore, efficient enrichment and early detection of CTCs are essential to achieve timely diagnosis of diseases. In this work, we constructed an innovative and sensitive single-nanoparticle collision electrochemistry (SNCE) biosensor for the detection of MCF-7 cells (human breast cancer cells) by immunomagnetic separation technique and liposome signal …

Author Spotlight, Fei Li, Yi-Ge Zhou, Yi-Lun Ying, Yong-Xin Li, Yu Huang, Zhen Wu

Journal of Electrochemistry

No abstract provided.

Exploring The Interconnectivity Between Soilless Substrate Hydraulic Properties And Plant Root Morphology, Kristopher S. Criscione

LSU Doctoral Dissertations

Horticultural container production heavily relies upon porous soilless substrates to mass produce specialty crops. Soilless substrates are responsible for continuously maintaining optimal water, mineral nutrients, and air balances to promote healthy root growth and support productive shoot yield (foliage or fruit). Increasing evidence of substrate research continues to highlight the strong relationships associated with root development and substrate physiochemical properties. Despite the importance of the root system for overall plant health, most horticultural research to-date has focused on shoot development. Research tends to report total root biomass as the primary root-growth metric; however, this results in several developmental features becoming …

Modern Lakeshore Processes And Historic Lake And Glacial Changes In Taylor Valley, Antarctica, Michael Stanley Stone

LSU Doctoral Dissertations

Taylor Valley, which opens to the Ross Sea, is one of several ice-free valleys comprising the McMurdo Dry Valleys, Antarctica. The valley is home to several close-basin, perennially ice-covered lakes, whose lake levels largely reflect a balance between meltwater inputs and lake ice ablation; both being driven by climate. A dynamic environment exists where the lake ice covers meet the lakeshore, with the ice grounding to the substrate throughout the cold and dark of winter, and melting to form a perimeter of thin-to-no ice around the lake during the summer. These marginal freeze-thaw regions are known as moats. Here, physical, …

Targeting Trem2 Signaling Shows Limited Impact On Cerebrovascular Calcification, Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller

2020-Current year OA Pubs

Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and a diagnostic criterion for primary familial brain calcification. We previously showed that microglia curtail the growth of small vessel calcification via the triggering receptor expressed in myeloid 2 (TREM2) in the

Bipolar Ionization Did Not Reduce Airborne Bacteria In A Lecture Hall, David A. Kormos, Nishit J. Shetty, Elliott T. Gall, Aaron J. Prussin, Amy Pruden, Linsey C. Marr

Mechanical and Materials Engineering Faculty Publications and Presentations

Ionization treatment of indoor air has attracted attention for its potential to inactivate airborne pathogens and reduce disease transmission, yet its real-world effectiveness remains unverified. We evaluated the impact of an in-duct, bipolar ionization system on airborne particles, including culturable bacteria, in a lecture hall. The ionizer was off with variable fan speed for 1 week, on with variable fan speed for a second week, and on with high and constant fan speed for a third week. We measured ion concentrations and aerosol particle concentrations, and we collected bioaerosol samples for analysis of 16S rRNA gene copies representing total bacteria …

Evaluating Indoor Air Quality In Residential Environments: A Study Of Pm2.5 And Co2 Dynamics Using Low-Cost Sensors, Kabir Bahadur Shah, Dylan Kim, Sai Deepak Pinakana, Mkhitar A. Hobosyan, Armando Montes, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Indoor air quality (IAQ) poses a significant public health concern, and exposures to high levels of fine particulate matter (PM2.5) and carbon dioxide (CO2) could have detrimental health impacts. This study focused on assessing the indoor air pollutants in a residential house located in the town of Mission, Hidalgo County, South Texas, USA. The PM2.5 and CO2 were monitored indoors: the kitchen and the bedroom. This investigation also aimed to elucidate the effects of household activities such as cooking and human occupancy on these pollutants. Low-cost sensors (LCSs) from TSI AirAssure™ were used in this study. They were deployed within …

Cardiovascular Findings In Klippel-Feil Syndrome: A Systematic Review, Abbigail Niewchas, Salma Alkhatib, Christopher Stewart, Mitchell Fisher, Randall Hansen, Alex Otto, Kent Mcintire, Suporn Sukpraprut-Braaten

Student Publications

Klippel-Feil syndrome (KFS) is a congenital disease defined by an abnormal fusion between cervical vertebrae. Due to the rarity of the disorder, its prevalence, along with its pathogenesis and associated conditions, remains to be clearly defined. The aim of this review is to summarize the findings of all case reports of KFS in PubMed over the last 10 years that describe cardiovascular disease, defects, or abnormalities. A total of 43 articles containing 46 reports were included from the 157 case reports considered. Cases were reviewed for commonality in biological sex and vertebral fusion and level using the Samartzis classification system …

Automation, Improvement, And Sensitivity Analysis Of 3d Parameterized Maize Stalk Models, Joseph Steven Carter

Theses and Dissertations

Maize is the most grown crop in the world. Each year, 5% of maize is lost due to a phenomenon known as stalk lodging (breakage of the stalk below the ear). One of the most promising solutions to stalk lodging is to design stalks with superior geometry to increase stalk strength. Researchers have developed a 3D parameterized maize stalk model, but these models take a long time to structurally analyze and are missing important material properties. This thesis addressed these problems by developing an automated package for analyzing the 3D parameterized maize stalk model, and by measuring the longitudinal shear …

Prompting Effective Learning Pathways: Applied Behavior Analysis In Practice, Brandie Ann Kretzschmar

Walden Dissertations and Doctoral Studies

The purpose of this quantitative study was to contribute to the literature for prompting interventions in the field of applied behavior analysis (ABA). This study examined the clinical utilization of prompting strategies with verbal operant programming across currently credentialed practitioners. Evidence-based practices are well known, but clinical guidance regarding prompting strategies is still emerging. This gap is potentially related to the lack of a prompting assessment to assist practitioners in creating clients' programming. To collect data a 52-question survey was used in this ethnographic study. Data was collected from 62 respondents, with 55 overall completed surveys. Errorless learning was reported …

The Rider (2024-10-28), Natalie Lapsley

The Rider Archives

Vol.10 No.10

Dna-Binding Proteins From Mbd Through Zf To Ben: Recognition Of Cytosine Methylation Status By One Arginine With Two Conformations, Xing Zhang, Robert M Blumenthal, Xiaodong Cheng

Faculty, Staff and Student Publications

Maintenance methylation, of palindromic CpG dinucleotides at DNA replication forks, is crucial for the faithful mitotic inheritance of genomic 5-methylcytosine (5mC) methylation patterns. MBD proteins use two arginine residues to recognize symmetrically-positioned methyl groups in fully-methylated 5mCpG/5mCpG and 5mCpA/TpG dinucleotides. In contrast, C2H2 zinc finger (ZF) proteins recognize CpG and CpA, whether methylated or not, within longer specific sequences in a site- and strand-specific manner. Unmethylated CpG sites, often within CpG island (CGI) promoters, need protection by protein factors to maintain their hypomethylated status. Members of the BEN domain proteins bind CGCG or CACG elements within CGIs to regulate gene …

Developmental-Status-Aware Transcriptional Decomposition Establishes A Cell State Panorama Of Human Cancers, Yikai Luo, Han Liang

Faculty, Staff and Student Publications

Background: Cancer cells evolve under unique functional adaptations that unlock transcriptional programs embedded in adult stem and progenitor-like cells for progression, metastasis, and therapeutic resistance. However, it remains challenging to quantify the stemness-aware cell state of a tumor based on its gene expression profile.

Methods: We develop a developmental-status-aware transcriptional decomposition strategy using single-cell RNA-sequencing-derived tissue-specific fetal and adult cell signatures as anchors. We apply our method to various biological contexts, including developing human organs, adult human tissues, experimentally induced differentiation cultures, and bulk human tumors, to benchmark its performance and to reveal novel biology of entangled developmental signaling in …

Prenatal Opioid And Alcohol Exposures: Association With Altered Placental Serotonin Transporter Structure And/Or Expression, Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Sandra Adele, Armine Darbinyan, Mary F Morrison, C Lindsay Devane, Sammanda Ramamoorthy, Laura Goetzl, Michael E Selzer

Faculty, Staff and Student Publications

Fetal exposures to many drugs of abuse, e.g., opioids and alcohol (EtOH), are associated with adverse neurodevelopmental problems in early childhood, including abnormalities in activity of the serotonin (5HT) transporter (SERT), which transports 5HT across the placenta. Little is known about the effects of these drugs on SERT expression. Pregnant women who used EtOH or opioids were compared to gestational age-matched controls using a structured questionnaire to determine prenatal substance exposure. Following elective pregnancy termination, placental membranous vesicles and exosomes were prepared from first and second trimester human placentas. Changes in EtOH- or opioid-exposed placental SERT expression and modifications were …

Single Nanobubble Formation On Au Nanoelectrodes And Au@Ws2 Nanoelectrodes: Voltammetric Analysis And Electrocatalysis, Xian-Zhun Luo, Xiao-Hu Chen, Yong-Xin Li

Journal of Electrochemistry

Taking advantage of the extremely small size of the gold nanodisk electrode, the single hydrogen nanobubble generated on the surface of the nanoelectrode was studied to evaluate its hydrogen evolution performance. It was found that compared with the bare gold nanodisk electrode, the bubble formation potential of the gold nanodisk electrode modified with tungsten disulfide quantum dots (WS₂ QDs) on the surface was more positive, indicating that its hydrogen evolution activity was higher. Microdynamic model analysis shows that the average standard rate constant of the rate-determining step of the hydrogen evolution reaction of gold nanoelectrodes modified with WS_{2 …}

Highly Sensitive Detection Of Strontium Ions Using Metal-Organic Frameworks Functionalized Solid-State Nanochannels, Xu-Gang Wang, Zheng-Xu He, De-Fang Ding, Xue-Qin Luo, Li Dai, Wei-Qi Zhang, Qun Ma, Yu Huang, Fan Xia

Journal of Electrochemistry

Strontium-90, a highly radioactive isotope, accumulates within the food chain and skeletal structure, posing significant risks to human health. There is a critical need for a sensitive detection strategy for Strontium-90 in complex environmental samples. Here, solid-state nanochannels, modified with metal-organic frameworks (MOF) and specific aptamers, were engineered for highly sensitive detection of strontium ion (Sr²⁺). The synergistic effect between the reduced effective diameter of the nanochannels due to MOF and the specific binding of Sr²⁺ by aptamers amplifies the difference in ionic current signals, enhancing detection sensitivity significantly. The MOF-modified nanochannels exhibit highly sensitive detection of …

Using A Natural Capital Risk Register To Support The Funding Of Seagrass Habitat Enhancement In Plymouth Sound, Guy Hooper, Matthew Ashley, Tom Mullier, Martin Attrill, Amelia Sturgeon, Zoe Sydenham, Mark Parry, Katey Valentine, Sian Rees

School of Biological and Marine Sciences

Seagrass is an important marine habitat that provides benefits to society in the form of ecosystem services. Services include the provision of food via fisheries, the regulation of water quality and the ability to sequester and store carbon. In the UK, seagrass beds are in decline, increasing the risk of ecosystem service loss. Current efforts to protect, restore and create seagrass habitat, beyond spatial management measures, rely on grant funding and donations. Emerging carbon, biodiversity and wider ecosystem service markets offering potential revenue sources could facilitate the enhancement of seagrass habitat at scale. Participation in ecosystem service markets, requires that …

Engineered Cas9 Variants Bypass Keap1-Mediated Degradation In Human Cells And Enhance Epigenome Editing Efficiency, Jianfeng Chen, Siyuan Su, Adrian Pickar-Oliver, Anna M Chiarella, Quentin Hahn, Dennis Goldfarb, Erica W Cloer, George W Small, Smaran Sivashankar, Dale A Ramsden, Michael B Major, Nathaniel A Hathaway, Charles A Gersbach, Pengda Liu

2020-Current year OA Pubs

As a potent and convenient genome-editing tool, Cas9 has been widely used in biomedical research and evaluated in treating human diseases. Numerous engineered variants of Cas9, dCas9 and other related prokaryotic endonucleases have been identified. However, as these bacterial enzymes are not naturally present in mammalian cells, whether and how bacterial Cas9 proteins are recognized and regulated by mammalian hosts remain poorly understood. Here, we identify Keap1 as a mammalian endogenous E3 ligase that targets Cas9/dCas9/Fanzor for ubiquitination and degradation in an 'ETGE'-like degron-dependent manner. Cas9-'ETGE'-like degron mutants evading Keap1 recognition display enhanced gene editing ability in cells. dCas9-'ETGE'-like degron …

Scale-Dependent Drivers Of Air-Sea Co2 Flux Variability, Amanda R. Fay, Dustin Carroll, Galen A. Mckinley, Dimitris Menemenlis, Hong Zhang

Faculty Research, Scholarly, and Creative Activity

In climate studies, it is crucial to distinguish between changes caused by natural variability and those resulting from external forcing. Here we use a suite of numerical experiments based on the ECCO-Darwin ocean biogeochemistry model to separate the impact of the atmospheric carbon dioxide (CO2) growth rate and climate on the ocean carbon sink — with a goal of disentangling the space-time variability of the dominant drivers. When globally integrated, the variable atmospheric growth rate and climate exhibit similar magnitude impacts on ocean carbon uptake. At local scales, interannual variability in air-sea CO2 flux is dominated by climate. The implications …

Adapting To Drought And Floods In The Semi-Arid Landscape Of Santa Cruz County, Arizona, Cynthia L. Sorrensen

The Geographical Bulletin

This paper analyzes the actions of key interest groups and major institutional regulatory agreements that influence land use change and water demand in Santa Cruz County, Arizona, in order to better understand the capacity of residents in the county to adapt to hydroclimatic hazards (drought and flooding). We found that there are strong special interest groups working in the region to ensure their own livelihoods and interests. At times, the actions of these groups enhance the adaptive capacity of the county, but their actions can also conflict with each other, producing a less-clear outcome for adaptation. We also note that …