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2024

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Applicability Of Reducing Valve Timing Overlap For Diesel Engines Under High Exhaust Back Pressure, Chien-Cheng Chen, Yuan-Liang Jeng, Shun-Chang Yen Jan 2024

Applicability Of Reducing Valve Timing Overlap For Diesel Engines Under High Exhaust Back Pressure, Chien-Cheng Chen, Yuan-Liang Jeng, Shun-Chang Yen

Journal of Marine Science and Technology–Taiwan

The exhaust back pressure of diesel engines becomes increasing higher nowadays. As an example, the De-NOx system and DE-SOx system necessitated by the increasingly stringent emission standards, would result in increased exhaust back pressure for those diesel engines adopting such systems. Some ships adopt underwater exhaust system to save space on the working deck and to reduce noise and air pollution, while the hydrostatic pressure under water level has made the exhaust back pressure of diesel engines getting much higher. Under high exhaust back pressure, to keep discharging exhaust unhindered and operating smoothly for diesel engine, it often results in …


Elimination Of Noise In A Ship Cabin Using Multi-Layered Acoustic Boards: An Apso And Sa Approach, Min-Chie Chiu, Ho-Chih Cheng Jan 2024

Elimination Of Noise In A Ship Cabin Using Multi-Layered Acoustic Boards: An Apso And Sa Approach, Min-Chie Chiu, Ho-Chih Cheng

Journal of Marine Science and Technology–Taiwan

A high level of noise, combined with pure tones, is often encountered in ship's cabins, leading to severe psychological and physiological issues for the crew. To address this problem, an indoor noise abatement solution becomes necessary that utilizes efficient acoustic boards integrated with resonators, positioned along the inner walls of the cabin. However, the thickness of the acoustic boards must be strictly limited due to maintenance and operational considerations. This limitation results in insufficient sound absorption capabilities and a restricted range of tuned frequencies, as the resonating frequency of a standard Helmholtz resonator is closely tied to its cavity. A …


Numerical Study On The Aerodynamic Performance Of Four Flettner Rotors By Varying Distance And Spin Ratio, Janghoon Seo, Dong-Woo Park Jan 2024

Numerical Study On The Aerodynamic Performance Of Four Flettner Rotors By Varying Distance And Spin Ratio, Janghoon Seo, Dong-Woo Park

Journal of Marine Science and Technology–Taiwan

The Flettner rotor is a wind-assisted propulsion system applied in eco-friendly ship to reduce greenhouse gas emissions. As the requirements of international regulations on greenhouse gas emissions become increasingly strict, multiple Flettner rotors are being applied, necessitating the evaluation of their performance with varying design parameters. The present study focuses on the aerodynamic performances of four Flettner rotors with variable design parameters of distance and spin ratio. Distances and spin ratios, including relative spin ratios, are considered. The drag and lift coefficients and lift-to-drag ratio of Flettner rotors are determined using Computational Fluid Dynamics (CFD), and the associated flow fields …


Underwater Image Enhancement Algorithm For Dual Color Spaces, Xingsheng Shen, Yalin Song, Shichang Li, Xiaoshu Hu Jan 2024

Underwater Image Enhancement Algorithm For Dual Color Spaces, Xingsheng Shen, Yalin Song, Shichang Li, Xiaoshu Hu

Journal of Marine Science and Technology–Taiwan

Targeting issues related to low contrast, blurring, and loss of detail prevalent in underwater image enhancement algorithms, we propose a dual-color space multiscale residual network (DMR-SCNet) based on SCNet. First, we introduce the HSV color space feature extraction module, which aims to optimize the color representation and saturation of underwater images. Subsequently, we propose the RGB color space denoising module, which focuses on repairing the content and structure of underwater images to enhance their clarity and visual quality. Finally, by designing the residual attention (RAB) module, we aim to further refine the detailed representation and feature extraction of underwater images. …


A Novel Identity Authentication Mechanism For Unmanned Maritime Vessels Communication Based On Mitre Att&Ck Framework, Junxian He, Shih-Hao Chang Jan 2024

A Novel Identity Authentication Mechanism For Unmanned Maritime Vessels Communication Based On Mitre Att&Ck Framework, Junxian He, Shih-Hao Chang

Journal of Marine Science and Technology–Taiwan

With the development of the smart shipping industry, unmanned vessel technology is rapidly evolving, accompanied by a demand for robust Internet of Things (IoT) communication security practices. Key communication technologies for the operation of unmanned vessels include external vessel communication. One crucial aspect is the verification of the identities of the parties involved in these communication systems, as this ensures secure and trusted interactions between unmanned vessels and port management authorities. Identity authentication plays a vital role in ensuring the secure communication of unmanned vessels.This paper aims to analyze potential risks related to identity authentication technology in unmanned vessel communication …


Corrigendum To “Applicability Of Reducing Valve Timing Overlap For Diesel Engines Under High Exhaust Back Pressure” Jan 2024

Corrigendum To “Applicability Of Reducing Valve Timing Overlap For Diesel Engines Under High Exhaust Back Pressure”

Journal of Marine Science and Technology–Taiwan

No abstract provided.


Distribution And Population Structure Of Corallivorous Drupella Snails In The Coral Reefs Of Kenting In Taiwan, Chih-Jui Tan, Dun-Ru Kang, Li-Lian Liu Jan 2024

Distribution And Population Structure Of Corallivorous Drupella Snails In The Coral Reefs Of Kenting In Taiwan, Chih-Jui Tan, Dun-Ru Kang, Li-Lian Liu

Journal of Marine Science and Technology–Taiwan

The corallivorous Drupella snails are common predators of living hard corals in the Indo-Pacific Ocean, and they can significantly threaten coral reef ecosystems when outbreaks occur. In Taiwan, a Drupella outbreak, which resulted in the dramatic decline of Acropora and Montipora corals, was reported in Penghu in 2002 – 2009. However, the Drupella species involved was not identified, and no further research has been conducted. To obtain current knowledge on the predation pressure of corallivorous snails on hard corals, we investigated benthic communities and the distribution and population structure of Drupella snails in the coral reefs of Kenting, Taiwan. The …


Evaluating The Connectivity Reliability Of The Seaborne Transportation Network Using Uncertainty Theory, Tianshou Liu, Haiyang Bian, Lin Feng, Chenyang Fan, Chaojun Ding, Grifoll Manel, Hongxiang Feng Jan 2024

Evaluating The Connectivity Reliability Of The Seaborne Transportation Network Using Uncertainty Theory, Tianshou Liu, Haiyang Bian, Lin Feng, Chenyang Fan, Chaojun Ding, Grifoll Manel, Hongxiang Feng

Journal of Marine Science and Technology–Taiwan

The shipping network serves as the backbone of international trade. However, due to unstable geopolitical conditions, unexpected events have occurred frequently in recent years that have impacted the global shipping supply chain, and this has placed enormous pressure and had adverse effects on seaborne transportation. To measure the reliability of the global shipping network under unexpected events, we abstract the global shipping network into a small world network using uncertainty theory. A method is proposed for selecting (i) the optimal reliable path and (ii) the optimal reliable path with a maximum measurement under different confidence intervals. Our approach is then …


Mechanical Property Analysis And Three-Dimensional Reverse Reconstruction Based On Corrosion Pit Characteristics Of Strong Corrosion Steel Plate, Qiujun Ning, Xiaosong Lu, Jiawei Lu Jan 2024

Mechanical Property Analysis And Three-Dimensional Reverse Reconstruction Based On Corrosion Pit Characteristics Of Strong Corrosion Steel Plate, Qiujun Ning, Xiaosong Lu, Jiawei Lu

Journal of Marine Science and Technology–Taiwan

To investigate the strong corrosion effect of 36% industrial hydrochloric acid on Q370 steel for bridges at room temperature. The surface morphology variations of the Q370 steel for bridges with corrosion time were measured and analyzed using a three-dimensional non-contact scanning profilometer. Subsequently, the standard monotonic tensile test was carried out to obtain the load-displacement curve and analyze the mechanical properties of the heavily corroded steel. Moreover, the constitutive model parameters of the heavily corroded steel were optimized. Furthermore, the heavily corroded steel model base on the actual corroded surface morphology was established, employing three-dimensional reverse reconstruction technology and finite …


Sea Ice Identification And Risk Assessment For Navigation In Ice Regions Based On Shipboard Camera Images, Tsung-Hsuan Hsieh, Xuan Lu, Shengzheng Wang, Wei Liu, Jianan Luo Jan 2024

Sea Ice Identification And Risk Assessment For Navigation In Ice Regions Based On Shipboard Camera Images, Tsung-Hsuan Hsieh, Xuan Lu, Shengzheng Wang, Wei Liu, Jianan Luo

Journal of Marine Science and Technology–Taiwan

In order to guarantee the safe navigation of vessels in icy regions and effectively capture sea ice risk information surrounding ships, this study introduces a sea ice identification and risk assessment process utilizing shipboard camera images. Firstly, based on the distribution characteristics of sea area, a hierarchical region segmentation algorithm is proposed to precisely remove interference factors and extract the region of interest. Then, a multivariate K-means clustering algorithm is proposed to classify sea ice classes based on various characteristics, including spatial similarity, sea ice area, sea ice thickness, gray scale, and other multivariate information. Finally, a method for small …


Optimization On Container Drayage Scheduling In Stochastic Time-Dependent Network, Qi Xu, Jie Huang, Xingyue Chen, Rui Cheng, Xiangyu Yin, Zhongzhen Yang Jan 2024

Optimization On Container Drayage Scheduling In Stochastic Time-Dependent Network, Qi Xu, Jie Huang, Xingyue Chen, Rui Cheng, Xiangyu Yin, Zhongzhen Yang

Journal of Marine Science and Technology–Taiwan

To ensure a reliable operation of container drayage transport system, this paper investigates the drayage scheduling problem in a stochastic time-dependent network. Based on the theory of the robust optimization, a mathematical model considering the attributes of “synchronized operation of multi machines” is built with the aim of minimization of the schedule delay in the whole system. A Simulated Annealing algorithm with Embedded Heuristics (SAEH) is designed for model solution. Comparisons between the results from the robust optimization and traditional expected value approach, and the results from the SAEH and CPLEX are conducted. Based on that, the effectiveness of our …


Offshore Vertical Axis Wind-Photovoltaic Power Plants: Development And Case Study, Victor V. Cheboxarov, Pavel N. Kuznetsov, Shun-Han Yang, Shiu-Wu Chau Jan 2024

Offshore Vertical Axis Wind-Photovoltaic Power Plants: Development And Case Study, Victor V. Cheboxarov, Pavel N. Kuznetsov, Shun-Han Yang, Shiu-Wu Chau

Journal of Marine Science and Technology–Taiwan

This paper examines the potential for the development and implementation of hybrid wind-solar power plants utilizing large-scale offshore vertical-axis wind turbines. The proposed solution aims to increase energy production and reliability through the integration of photovoltaic modules directly into the wind turbine structure. Schematics of photovoltaic modules on the upper annular surface of the respective wind turbine are considered. The operation of the hybrid power plant is described. Equations to estimate the power characteristics of the plant are given. The case study analyzes the potential energy production of a hybrid marine power plant with a diameter of 200 m at …


Harvest By Autoflocculation, Biomass, And Carotenoid Production In Sequential Batch Culture Of Haematococcus Pluvialis Under High Ionic Strength And Macroelements Content, J. Galán-González, I. Quintero-Zapata, M Elías-Santos, L.J. Galán-Wong, U.J. López-Chuken, C Guajardo-Barbosa, J.C Beltrán-Rocha Jan 2024

Harvest By Autoflocculation, Biomass, And Carotenoid Production In Sequential Batch Culture Of Haematococcus Pluvialis Under High Ionic Strength And Macroelements Content, J. Galán-González, I. Quintero-Zapata, M Elías-Santos, L.J. Galán-Wong, U.J. López-Chuken, C Guajardo-Barbosa, J.C Beltrán-Rocha

Journal of Marine Science and Technology–Taiwan

Haematococcus pluvialis is a microalga with significant potential due to its capacity to produce carotenoids with antioxidant and nutraceutical benefits. However, the cost of harvesting this microalga, constituting over 30% of total expenses in large-scale production, is a major concern. Efficient flocculation, aiding in cell separation from the culture medium, is crucial to address this issue. The study contrasted Bold’s Basal Medium (BBM) with Lopez-Chuken & Young nutrient solution (LC-Y). The heightened salt content in LC-Y plays a crucial role in fostering saline stress, which is essential for evaluating H. pluvialis flocculation, biomass yield, and carotenoid production. To assess stability …


Research Progress On Ship Trajectory Prediction In Marine Transportation, Xiangen Bai, Kai Ye, Xiaofeng Xu Jan 2024

Research Progress On Ship Trajectory Prediction In Marine Transportation, Xiangen Bai, Kai Ye, Xiaofeng Xu

Journal of Marine Science and Technology–Taiwan

The prediction of ship navigation trajectories is crucial for ensuring maritime navigation safety and forecasting risk. In recent years, extensive research has been conducted on the prediction of ship navigation trajectories at home and abroad, and some results have been achieved. At present, most research on ship navigation trajectory prediction relies heavily on automatic identification system (AIS) data and the historical trajectories of ships. This study first reviews the research background and current situation of ship navigation trajectory prediction. Second, it provides an overview of ship navigation trajectory prediction, with an emphasis on sorting out and elaborating on artificial intelligence …


Numerical Investigations On Particle Collection And Discharge Of Rounded Rectangle Aquaculture Tank In Dual-Diagonal-Inlet Layout, Xiaozhong Ren, Shupeng Du, Hangfei Liu, Xianying Shi, Meng Li, Xian Wang, Suping Liu Jan 2024

Numerical Investigations On Particle Collection And Discharge Of Rounded Rectangle Aquaculture Tank In Dual-Diagonal-Inlet Layout, Xiaozhong Ren, Shupeng Du, Hangfei Liu, Xianying Shi, Meng Li, Xian Wang, Suping Liu

Journal of Marine Science and Technology–Taiwan

To improve the space utilization rate of aquaculture tanks in aquaculture facilities and investigate the effect of the length-width ratio parameter (abbr. L/W, with L being the length of the tank and W being its width) on the particle collection and discharge characteristics of the rounded rectangle aquaculture tank with diagonal double inlet pipes. The study simulates the particle discharge procedure of the tank using a solidliquid two-phase numerical model (discrete phase model and RNG k-ε turbulence model adopted). The validity of the numerical model was confirmed through physical experiments. The simulation results for two jet condition indicate that when …


Human Platelet Derived Mitochondrial Opa-1 Isoforms And Interaction With Tdp-43 In Neurodegenerative Diseases, Su Han Lee, Duyen Pham, Edina Kosa, Abdulbaki Agbas Jan 2024

Human Platelet Derived Mitochondrial Opa-1 Isoforms And Interaction With Tdp-43 In Neurodegenerative Diseases, Su Han Lee, Duyen Pham, Edina Kosa, Abdulbaki Agbas

Faculty and Staff Publications

Optic atrophy 1 (OPA-1) is a GTPase protein that controls mitochondrial fusion, cristae integrity, and mtDNA maintenance. In neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), the mitochondrial network morphology is compromised. Studies on TAR-DNA binding protein 43 (TDP-43) has been the focus in our lab. OPA-1 and TDP-43 interaction may shed a light on how aberrant TDP-43 interacts with OPA-1, which will lead to mitochondrial dysfunction. The preliminary study tested the idea of whether OPA-1 and TDP-43 are physically interacting in human platelet derived mitochondria obtained from healthy human subjects.


2024 Conference Program, Georgia Southern University Jan 2024

2024 Conference Program, Georgia Southern University

SoTL Commons Conference

Conference program for 2024


Common Data Set, 2023-2024, Planning, Research, And Policy Analysis Jan 2024

Common Data Set, 2023-2024, Planning, Research, And Policy Analysis

Common Data Set (2001-present)

Common Data Set 2023-2024 for Illinois State University


Host-Defense Piscidin Peptides As Antibiotic Adjuvants Against Clostridioides Difficile, Adenrele Oludiran, Areej Malik, Andriana C. Zourou, Yonghan Wu, Steven P. Gross, Albert Siryapon, Asia Poudel, Kwincy Alleyne, Savion Adams, David S. Courson, Myriam L. Cotten, Erin B. Purcell Jan 2024

Host-Defense Piscidin Peptides As Antibiotic Adjuvants Against Clostridioides Difficile, Adenrele Oludiran, Areej Malik, Andriana C. Zourou, Yonghan Wu, Steven P. Gross, Albert Siryapon, Asia Poudel, Kwincy Alleyne, Savion Adams, David S. Courson, Myriam L. Cotten, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

The spore-forming intestinal pathogen Clostridioides difficile causes multidrug resistant infection with a high rate of recurrence after treatment. Piscidins 1 (p1) and 3 (p3), cationic host defense peptides with micromolar cytotoxicity against C. difficile, sensitize C. difficile to clinically relevant antibiotics tested at sublethal concentrations. Both peptides bind to Cu2+ using an amino terminal copper and nickel binding motif. Here, we investigate the two peptides in the apo and holo states as antibiotic adjuvants against an epidemic strain of C. difficile. We find that the presence of the peptides leads to lower doses of …


Quantification Of Antiretroviral Drug Emtricitabine In Human Plasma By Surface Enhanced Raman Spectroscopy, Marguerite R. Butler, Terry A. Jacot, Sucharita M. Dutta, Gustavo F. Doncel, John B. Cooper Jan 2024

Quantification Of Antiretroviral Drug Emtricitabine In Human Plasma By Surface Enhanced Raman Spectroscopy, Marguerite R. Butler, Terry A. Jacot, Sucharita M. Dutta, Gustavo F. Doncel, John B. Cooper

Chemistry & Biochemistry Faculty Publications

In this study, reproducible label-free detection and quantification of the antiretroviral drug emtricitabine (FTC) down to 78 ng/mL in human plasma by surface enhanced Raman spectroscopy (SERS) is presented. A novel plasma sample pretreatment method using silver nitrate and silver colloidal nanoparticles (Ag CNPs) was used to prepare the plasma samples for analysis. The pretreated plasma samples were evaporated to dryness on an aluminum surface and a computer-controlled Raman scanning system was used to collect spatially resolved SERS spectra of the entire surface. Calibration curves of commercial human plasma samples containing FTC in a concentration range of 5000 to 78 …


Novel Supercritical Biodiesel Plant Design & Process Scale-Up, Ghana Shyam Paudel Jan 2024

Novel Supercritical Biodiesel Plant Design & Process Scale-Up, Ghana Shyam Paudel

Doctoral Dissertations

"Current energy prices, national energy security, and global climate change fuel our momentum to find efficient advanced fuels choices. In this study, biodiesel processing, and a novel design for next generation biodiesel plants are explored. During a National Science Foundation (NSF) I-Corps project we identified three creative and profitable improvements to the process: 1. Incorporating Energy intensive separations and reactions 2. Utilizing Low commodity glycerol and 3. Applying process intensification principles.

Current biodiesel processes are catalyzed processes using continuous stir reactors with distillation systems to separate material constituents. We tested a lab-scale nocatalyst supercritical biodiesel process using waste cooking oil …


Advanced Mass Spectrometry Method Development And Applications For Assessment Of Traumatic Brain Injury And Legionella Pneumophila Dissinfection With Copper, Austin Chase Sigler Jan 2024

Advanced Mass Spectrometry Method Development And Applications For Assessment Of Traumatic Brain Injury And Legionella Pneumophila Dissinfection With Copper, Austin Chase Sigler

Doctoral Dissertations

"Pathological processes often involve complex biochemical changes which can be assessed using advanced mass spectrometry. In this present dissertation, two fields were studied: traumatic brain injury (TBI), and water contamination by L. pneumophilia. TBI is a pressing public health concern for which current clinical tools remain inadequate. We present newly developed mass spectrometric methods to access metabolites associated with blast induced TBI. We applied these methods to the biofluids of soldiers conducting explosives training. Significant changes in several metabolites were observed between pre- and post-blast specimens, including changes that increased with repeated exposure. These changes point to the possibility of …


Structural And Functional Consequences Of Pde6 Prenylation In Rod And Cone Photoreceptors, Faezeh Moakedi Jan 2024

Structural And Functional Consequences Of Pde6 Prenylation In Rod And Cone Photoreceptors, Faezeh Moakedi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Phosphodiesterase-6 (PDE6) serves as a pivotal component in the phototransduction pathways of both cone and rod photoreceptors. In cones, PDE6 consists of tetrameric subunits: inhibitory (γ') and catalytic (α'). The catalytic subunit, PDE6α', contains a C-terminal prenylation motif. Deletion of this motif is associated with achromatopsia (ACHM), a form of color blindness. The mechanisms underlying the disease and the roles of PDE6 lipidation in vision remain elusive. Meanwhile, rod PDE6 is composed of α and β catalytic subunits and γ inhibitory subunits, with alterations in the C-terminal "prenylation motif" of PDE6β linked to retinitis pigmentosa (RP) pathology. In this comprehensive …


A Legacy Of Labor: Maternity Narratives In 1960s And 1970s North American Life Writing, Katelynn Ann Vogelpohl Jan 2024

A Legacy Of Labor: Maternity Narratives In 1960s And 1970s North American Life Writing, Katelynn Ann Vogelpohl

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

A Legacy of Labor: Maternity Narratives in 1960s and 1970s North American Life Writing

Katelynn Ann Vogelpohl

The phenomenon of maternity has been repeatedly described as an event that shakes the very foundations of social and physical identity. As the flesh of the pregnant person literally divides to produce new life, one subject becomes enclosed within another, dramatically affecting the pregnant person’s sense of self and causing a confluence of intense, and often conflicting, feelings. In North America, there are two dominant, and seemingly opposing, discourses on pregnancy and childbirth: the institutional medical discourse and the natural childbirth discourse. …


An Investigation Into Secondary Transfer Of Trace Dna To Evidentiary Items Via Nitrile Gloves During Crime Scene Examination, Molly G. Younker Jan 2024

An Investigation Into Secondary Transfer Of Trace Dna To Evidentiary Items Via Nitrile Gloves During Crime Scene Examination, Molly G. Younker

Graduate Theses, Dissertations, and Problem Reports (ETD)

An investigation into secondary transfer of trace DNA to evidentiary items via nitrile gloves during crime scene examination

Molly G. Younker, B.S.

The introduction of highly sensitive DNA profiling kits has led to an increase in success with samples containing sub-nanogram amounts of DNA such as touched or handled objects including doorknobs, tools, steering wheels, etc. Such trace DNA is easily transferred between individuals and objects. Studies have shown that in addition to primary transfer due to direct contact, trace DNA can also be indirectly transferred in secondary and tertiary transfer steps which do not require direct contact. Nitrile gloves …


Evaluating The Role Of Glucocorticoids On The Host Response To Helicobacter Pylori Infection, Sara Druffner Jan 2024

Evaluating The Role Of Glucocorticoids On The Host Response To Helicobacter Pylori Infection, Sara Druffner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gastric cancer is the fifth most common cancer and the fifth leading cause of cancer deaths worldwide. Helicobacter pylori infection is the number one risk factor for gastric cancer development. Roughly 50% of the world’s population is infected with H. pylori, though only 1-3% of those infected will develop cancer. H. pylori drives chronic inflammation that creates the requisite environment for carcinogenesis, yet it remains unclear why some individuals develop cancer and others do not. Most mechanistic studies are done in mice, however H. pylori is not a natural mouse pathogen. Research is typically done either with mouse-adapted strains of …


Advanced Techniques In Time Series Forecasting: From Deterministic Models To Deep Learning, Xue Bai Jan 2024

Advanced Techniques In Time Series Forecasting: From Deterministic Models To Deep Learning, Xue Bai

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation discusses three instances of temporal prediction, applied to population dynamics and deep learning.

In population modeling, dynamic processes are frequently represented by systems of differential equations, allowing for the analysis of various phenomena. The first application explores modeling cloned hematopoiesis in chronic myeloid leukemia (CML) via a nonlinear system of differential equations. By tracking the evolution of different cell compartments, including cycling and quiescent stem cells, progenitor cells, differentiated cells, and terminally differentiated cells, the model captures the transition from normal hematopoiesis to the chronic and accelerated-acute phases of CML. Three distinct non-zero steady states are identified, representing …


Evaluating The Efficacy Of The Archaeal Proteasome To Alleviate Protein-Misfolding Retinopathy, Celine Brooks Jan 2024

Evaluating The Efficacy Of The Archaeal Proteasome To Alleviate Protein-Misfolding Retinopathy, Celine Brooks

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nearly all neurodegenerative diseases (NDs) and some eye diseases are characterized by the presence of misfolded and aggregated proteins. The ubiquitin proteasome system (UPS) is responsible for degrading the majority of proteins including misfolded and aggregated proteins. However, in NDs the performance of the UPS is impaired, and this impairment partially comes from these protein aggregates inhibiting the proteasome. This inhibition leads to an accumulation of protein aggregates, more proteasomal inhibition, and fewer chaperones for newly synthesized proteins, triggering a collapse in proteostasis, which is thought to contribute to the pathogenesis of NDs. Consequently, stimulating proteasome function is being investigated …


Investigation Of L-Serine Synthesis And Transport As Stabilizing Feedback Mechanisms Within The Tsetse-Wigglesworthia Symbiosis, Ryan Phillips Jan 2024

Investigation Of L-Serine Synthesis And Transport As Stabilizing Feedback Mechanisms Within The Tsetse-Wigglesworthia Symbiosis, Ryan Phillips

Graduate Theses, Dissertations, and Problem Reports (ETD)

Tsetse flies (Glossina morsitans), which are the obligate vectors of Old-World trypanosomes (Trypanosoma spp.) that cause African trypanosomiasis, have a bacteriome that houses the intracellular endosymbiont Wigglesworthia glossinidia. The ancient coevolution of these species has led to the integration of Wigglesworthia metabolism into tsetse physiology and a subsequent reliance on nutrient exchange for maintaining the fitness of both partners. The establishment of this obligate mutualism has facilitated the emergence of feedback mechanisms that stabilize the symbiosis, such as that which involves the exchange of L-serine and B vitamins. The Gammaproteobacteria Wigglesworthia supplement B vitamins lacking …


Individualized Ideological Enclosures: The Generative Ai Crisis And How Consumers Can Reclaim Their Feeds, Sydney Rose Jan 2024

Individualized Ideological Enclosures: The Generative Ai Crisis And How Consumers Can Reclaim Their Feeds, Sydney Rose

Catholic University Journal of Law and Technology

No abstract provided.