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Investigation Of L-Serine Synthesis And Transport As Stabilizing Feedback Mechanisms Within The Tsetse-Wigglesworthia Symbiosis, Ryan Phillips

Graduate Theses, Dissertations, and Problem Reports (ETD)

Tsetse flies (Glossina morsitans), which are the obligate vectors of Old-World trypanosomes (Trypanosoma spp.) that cause African trypanosomiasis, have a bacteriome that houses the intracellular endosymbiont Wigglesworthia glossinidia. The ancient coevolution of these species has led to the integration of Wigglesworthia metabolism into tsetse physiology and a subsequent reliance on nutrient exchange for maintaining the fitness of both partners. The establishment of this obligate mutualism has facilitated the emergence of feedback mechanisms that stabilize the symbiosis, such as that which involves the exchange of L-serine and B vitamins. The Gammaproteobacteria Wigglesworthia supplement B vitamins lacking …

Individualized Ideological Enclosures: The Generative Ai Crisis And How Consumers Can Reclaim Their Feeds, Sydney Rose

Catholic University Journal of Law and Technology

No abstract provided.

Social Support In Black Individuals: The Moderating Effects On The Relationship Between Resilience And Well-Being, Imani Elise Crosby

College of Graduate Studies: Theses & Dissertations

Black individuals possess numerous strengths and positive contributions that build strong communities and cultivate psychological well-being (Biglan et al., 2012). However, much of the current literature focuses on hardships Black individuals face, skewing the larger discourse of their lived experience. This exclusive focus on adversity often neglects pathways by which Black people thrive and flourish. It is important to consider how Black experiences relate to a sense of well-being. Resilience, or the ability to “bounce back” from adverse experiences is linked well-being outcomes (APA, 2012). However, it is unknown whether the promotive effects of resilience directly contribute to well-being outcomes …

Targeting Pyruvate Metabolism Leads To Distinct Cd8+ T Cell Responses To Virus Infection And Cancer, Taewook Kang

Dartmouth College Ph.D Dissertations

CD8⁺ T cells are crucial immune cells that control viruses and cancers due to their high antigen specificity and proliferative capacity. Consequently, CD8⁺ T cells are being extensively explored in adoptive T cell therapy for cancer, autoimmune diseases, and infections in clinical and pre-clinical studies. Given that T cells rely on nutrient microenvironments and employ various nutrient processing pathways, metabolic intervention presents a promising strategy to enhance CD8⁺ T cell function and differentiation.

Pyruvate dehydrogenase (PDH) serves as a critical bifurcation point in the metabolic pathway, determining whether glucose-derived pyruvate undergoes mitochondrial oxidative phosphorylation (OXPHOS) or cytosolic …

Strategies Teachers Use To Encourage Student Reading Motivation And Engagement In The High School Setting: A Generic Qualitative Study, Shelia Tate

Theses and Dissertations

This applied dissertation was designed to provide an understanding of the practices and strategies used by Title 1 high school teachers to promote student reading motivation and engagement. Engaging students in the curriculum and motivating them to read is essential to a successful classroom experience. As districts move to a more prescribed curriculum with provided scope and sequence, teachers look for ways to engage their students and provide relevant resources to meet their students' needs creatively.

The researcher interviewed teachers to explore their beliefs, strategies, and practices for fostering student reading motivation and classroom engagement in high school. The guiding …

Investigation Of The Essential Oil Constituents Of Pimenta Racemosa Aerial Parts And Evaluation Of Its Antiviral Activity Against Hsv 1 And 2, Fathia S. Elshaarawy, Mohamed I. S. Abdelhady, Wafaa Hamdy, Haitham A. Ibrahim

Trends in advanced sciences and technology

Pimenta racemosa is a well-known plant used in traditional medicine to treat several ailments. Current pharmaceutical industries rely heavily on the discovery of secondary metabolites found in plants to aid in the development of novel drugs with potential biological activity. This study aimed to investigate the essential oil constituents of Pimenta racemose (Mill.) J. W. Moore aerial parts (leaves and small branches) and evaluate its antiviral activity. The essential oil was prepared by conventional hydro distillation method. The prepared oil was analyzed by GC/MS. Identification of the essential oil constituents was achieved by comparing retention indices (RI) relative to standard …

Impact Of Glottis Area On Airflow Dynamics In The Human Trachea Using A Simplified Stenosis Pipe Model, Amany M. Kamal, Momtaz Sedrak, Abouelmagd Abdelsamie

Trends in advanced sciences and technology

A complex transitional flow is produced in the larynx during air inhalation process, pivotal for fundamental comprehension and medical advancements in treatment methodologies. This study delves into the influence of the glottis region utilizing a simplified stenosis pipe geometry, examining two distinct cases: (1) the axisymmetric case and (2) the eccentric case. Reynolds-averaged Navier–Stokes equations with shear stress transport (SST) 𝑘 − 𝜔 turbulence model with intermittency transition activated with steady, Newtonian, and incompressible airflow have been used. The analysis underscores the significant impact of the eccentricity on the velocity by increasing 0.6% comparing with axisymmetric case, also particularly affecting …

Insulin Responses, Diet Composition, And Fat Loss, Amanda Finn

All ETDs from UAB

Some but not all studies show participants who have higher baseline insulin responses lose more weight on a low glycemic load compared to a high glycemic load diet. Most prior research tested the relationship between insulin and weight changes with only one insulin response variable, such as insulin from an orally or intravenously (IV) administered metabolic test. We tested whether insulin responses (IV or oral) predicted changes in body fat among participants undergoing diet-induced weight loss. This study was a secondary analysis of a clinical trial. In the parent study, participants were randomized to either a reduced carbohydrate (ReducedCHO) or …

Does Ceo Education Matter? The Relationship Between Doctoral-Educated Hospital Ceos And Organizational Performance, Kofi Ali Cash

All ETDs from UAB

One of the most pressing issues in healthcare strategic leadership research is identifying which hospital chief executive officer (CEO) characteristics possess a significant and favorable relationship to organizational performance. However, little is known about the relationship between hospitals led by doctoral-educated CEOs and organizational performance. This study adds to our knowledge by examining the relationship between doctoral-educated hospital CEOs and selected financial and patient safety outcomes. UET served as the theoretical framework and guided the examination of the relationship between the selected dependent and independent variables. This study’s population included 509 acute-care hospitals across nine states, requiring a minimum four-year …

Utilization Of Romosozumab During Covid-19 Pandemic Among U.S. Medicare Beneficiaries, Ye Liu

All ETDs from UAB

Osteoporosis is increasingly recognized as a major public health issue in the aging U.S. population. Shortly after the licensure of romosozumab, an injectable medication indi-cated for women with postmenopausal osteoporosis at high risk of fracture administered by health care provider monthly, the COVID-19 pandemic broke out, which caused ma-jor disruptions to the delivery of health care across the nation. The pandemic dispropor-tionately affected minority and economically disadvantaged communities, exacerbating many pre-existing health disparities. Romosozumab has the highest dosing frequency among common injectable osteoporosis medications in the U.S. that require an office visit for injection, making romosozumab adherence more susceptible to …

Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter

All ETDs from UAB

Positron emission tomography (PET) imaging agents play a transformative role in personalized medicine through their application in disease diagnosis and immunotherapy monitoring, focusing on chemokine receptors, TH1-activated immune cells, and tuberculosis (TB) diagnostics. In immuno-oncology, accurately assessing TH1-activated immune cells in the tumor microenvironment (TME) is vital for evaluating cancer immunotherapy efficacy. Chemokine receptors, crucial in cellular signaling and inflammatory reactions, play a significant role in TH1 responses, thus serving as a potential area of interest in elucidating these anti-tumor responses. Through our work a novel CXCR3-targeting immunoPET probe, [89Zr]DFO-αCXCR3, was developed to detect and quantify these cells. This probe …

Titanium-45 Radiochemistry For The Development Of Pet Radiopharmaceuticals, Fnu Shefali

All ETDs from UAB

Imaging using nuclear medicine techniques has enabled non-invasive measurements of biomarkers for a wide range of diseases including cancer and neurodegenerative disorders. The production and characterization of new radioisotopes are crucial steps in designing radiopharmaceuticals for nuclear imaging applications. 45Ti is a novel radionuclide with desired physical characteristics for use in Positron Emission Tomography (PET) imaging. The half-life of 3.08 h is ideal for the imaging of small peptides. In addition, the 45Ti decay by positron emission (85 %) and a low mean positron energy (0.439 MeV) offers high spatial resolution. The production route of 45Ti is straightforward due to …

Phosphate Drives Pulmonary Inflammation Through Fgfr1, Erk, And Akt Signaling, Seth Bollenbecker

All ETDs from UAB

Chronic kidney disease (CKD) is characterized as irreversible progressive loss of renal function and affects over one tenth of the global population. Although CKD-associated comorbidities contribute significantly to its mortality, the lungs are often not considered. Lung diseases make up three of the top six leading causes of death worldwide and share many comorbidities with CKD. Clinical reports show that CKD patients are more likely to develop obstructive and restrictive lung diseases, but the mechanisms underlying this propensity for CKD-associated pulmonary complications are unknown. Hyperphosphatemia and associated elevations of fibroblast growth factor (FGF) 23, two of many consequences of reduced …

Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang

All ETDs from UAB

This dissertation focuses on developing predictive modeling using data from two areas: clinical data and microbiome data. Compositional data in real life are mainly represented by relative proportions. With the advancement of next-generation sequencing (NGS) technology, researchers can now collect a large volume of metagenomic sequencing data, which is valuable for investigating associations between the microbiome and host diseases. Current methods for dealing with such data are either constrained by generalization or limited by application. In the first part, to address this, we propose Bayesian compositional generalized linear models for analyzing microbiome data (BCGLM). This model incorporates a structured regularized …

Using Hope To Cope: Chronic Stress, Religious Coping, And Masked Hypertension In African American Adults: The Jackson Heart Study, Miriam Miles

All ETDs from UAB

USING HOPE TO COPE: CHRONIC STRESS, RELIGIOUS COPING, AND MASKED HYPERTENSION IN AFRICAN AMERICAN ADULTS: THE JACKSON HEART STUDY ABSTRACT Chronic stress experienced at home or work has been associated with acute increases in blood pressure (BP) measured in the doctor’s office. Few data are available on the association of chronic stress with BP measured outside of the office setting. Religious coping, applying religious beliefs to adapt to stressful situations, and functional and structural social support may protect against MHT by promoting active coping behaviors and increasing emotional well-being. High levels of religious involvement and high social support have been …

Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray

All ETDs from UAB

USING THE SOCIAL ECOLOGICAL MODEL TO ASSESS THE CORRELATES OF UNPROTECTED SEX AMONG AFRICAN AMERICAN EMERGING ADULTS SHIRLACIA S. GRAY DEVELOPMENTAL PSYCHOLOGY ABSTRACT Background: The Centers for Disease Control and Prevention (CDC) reported that HIV diagnoses for Black/African American men and women are 8x and 15x higher than white individuals, respectively. While the social determinants of health largely influence HIV transmission rates, reducing risky behaviors can lower the risk for HIV. This current study used the Social Ecological Model to investigate correlates of unprotected sex. Methods: Participants were recruited through respondent-driven sampling. Participant's demographics (age, gender, years of education, financial …

Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn

All ETDs from UAB

Resistive squat exercise is a well-established technique to enhance the strength of muscles and bone of the back in humans. Such type of exercise could prove highly beneficial for individuals with pathological condition of the back such as osteoporosis. Notably, the rehabilitation programs aimed at strengthening the muscles and bone of the back require the knowledge of the patient’s one repetition maximum (1RM). Finding the 1RM squat value could lead to injury due to the higher weights involved. In addition, testing for 1RM could be not feasible in older populations or young population with chronic back conditions The isometric squat …

Effect Bioactive Material Have On Tooth Demineralization, Taillk Gomes

All ETDs from UAB

The objective of this in vitro study is to compare the inhibition of demineralization of root dentin caused by the presence of different restorative materials using Vickers Hardness (HV) test (microhardness) test and polarized light microscopy (PLM).

A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen

All ETDs from UAB

Transgender individuals experience many challenges within the healthcare system including discrimination, socioeconomic struggles, financial strains, a lack of educated healthcare providers, and a health system framework that makes it even more challenging for them to receive their medical needs (Korpaisarn and Safer). One contributing factor to this lack of education is that on average medical schools in the United States only spend approximately five hours total on the health needs related to lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals (Miller et al.). Another contributing factor is the stigma around LGBTQ individuals within the medical community. The stigma is concerning …

3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark

All ETDs from UAB

Ovarian cancer is the 5th leading cause of cancer deaths for women, primarily due to treatment resistant and/or recurrent disease. Most cases of ovarian cancer are not diagnosed until distant metastases have formed, which drastically reduces overall survival. The median age at diagnosis is 63 and most cases occur in patients who are peri- and post-menopausal. There is a critical gap between the clinical presentation of ovarian cancer and the preclinical models used to study the disease. Most preclinical in vivo investigations use mice who are between 6 and 12 weeks old, which corresponds to roughly a 20-year-old human. Therefore, …

Temporal And Epigenetic Mechanisms Underlying Dietary Phytochemicals In Breast Cancer Prevention, Andrew Brane

All ETDs from UAB

Breast cancer (BC) is a widespread malignancy that, despite advancements in treatments and improvements in survival, had an estimated 297,790 new cases and 43,170 mortalities in 2023. With around 1 in every 8 women in the US expected to be diagnosed with BC at some point in their lives, the economic, societal, and healthcare burdens associated with this disease cannot be understated. Because of this, treatments and preventions that are affordable, efficacious, and easily administered are in high demand. Preventive therapies have shown great promise in reducing disease burden with relatively few serious side effects. BC prevention through the consumption …

The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain

All ETDs from UAB

Background: Fragility fractures pose a significant healthcare and economic burden in the United States. While age and bone mineral density (BMD) are the primary established risk factors for fragility fractures, the relationship between cardiovascular disease (CVD) and fractures remains underexplored. The primary objective of this analysis was to estimate the association of CVD risk with fractures in postmenopausal women. Methods: Utilizing 30 years of data from the WHI, Atherosclerotic Cardiovascular Disease (ASCVD) risk scores were computed using baseline age, race, systolic blood pressure, total cholesterol, high-density lipoprotein, diabetes, anti-hypertension medications, and smoking. Fracture outcomes encompassed any clinical fracture, major osteoporotic …

Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal

All ETDs from UAB

The Hyaluronate Lyase derived from Group A streptococcal bacteriophage H4489A gene (HylP) is known for cleaving the glycosidic bonds of high molecular weight hyaluronic acid (HMWHA), a substance often overexpressed in certain types of cancer cells. This enzymatic action produces HA oligosaccharides. Previous research, conducted by our team, has demonstrated that these oligosaccharides play a significant role in reducing the invasion, migration, and proliferation of breast cancer cells. This effect occurs through the disruption of Erk1/2 activation and RhoA expression. This bacteriophage hyaluronate lyase (HylP), a 40kDa protein, possesses a unique collagen-like sequence, consisting of 30 amino acids in a …

Mixed Martial Arts, Meaning, And Behavioral Peace: Examining Social Relationships In A Diverse Environment, Dana Dawson

All ETDs from UAB

This thesis investigates the manifestation of behavioral peace within the diverse subcultures of mixed martial arts (MMA) gyms, drawing from the operational definition provided by peace ethology, which encompasses more than just the absence of violence. Peace ethology investigates how behavioral peace is achieved through mutual interests, tolerance, helping, sharing, and the avoidance of aggressive confrontation. This thesis explores how behavioral peace manifests in environments characterized by controlled violence and vulnerability, focusing on three MMA gyms in Alabama. Employing an ethnographic and ethological framework, the methodology blends autoethnography with participant observations and semi-structured interviews to comprehend the cultural, environmental, and …

Investigating Impacts Of Caregiving On Cognitive Function: Role Of Social Support, Lu Tian

All ETDs from UAB

Study Aim: Using the stress process model as a framework, this dissertation aims to investigate the role of social support on the influence of informal caregiving on cognitive function of caregivers aged 50 years and older and to look at potential gender and racial differences in this association. Method: Leveraging data from the 2016 to 2020 waves of the Health and Retirement Study (HRS), this research employs Ordinary Least Squares (OLS) regression analysis to examine the influence of caregiving on the cognitive function of older adults. To comprehensively understand the pathways through which caregiving impacts cognitive outcomes, I use mediation …

Novel Roles Of Rab35 In Development And Disease, Kelsey Ruth Clearman

All ETDs from UAB

As the largest and most dynamic family of GTPases within the mammalian cell, Rabs play an essential role as molecular switches in regulating intracellular vesicular trafficking and serve as significant signaling transducers. Over the last few decades, Rabs have been identified to regulate endocytic, transcytosis, and exocytotic pathways, and mutations in Rabs, or alterations in downstream effectors lead to embryonic lethality and diseases such as cancer and ciliopathies. Ciliopathies are a class of pathologies that result from defects in structure or function of the primary cilia. Primary cilia, found on virtually all mammalian cells, is a microtubule-derived appendage that relies …

Catecholamines And Catecholamine Resistance In Animal Models Of Metabolic Syndrome, Robert Follett Rosencrans

All ETDs from UAB

The sympathetic nervous system is a key regulator of energy homeostasis, in part, through the control of white adipose tissue lipolysis. Sympathetic nerves modulate adipose tissue physiology through the release of catecholamines, particularly norepinephrine, onto alpha- and beta-adrenergic receptors (a-AR; B-AR). Lipolysis refers to the breakdown of triglycerides into glycerol and free fatty acids, often in response to activation of B2/3-AR. Beta adrenergic activation of lipolysis is widely known to be impaired in patients with metabolic syndrome and animal models thereof (catecholamine resistance). Recent studies have demonstrated that catecholamine regulation of adipokine release is also disrupted, suggesting that catecholamine resistance …

Fentanyl Overdoses And Use Of Randox Multistat For Investigative Purposes, Clarissa Danielle Lawen

All ETDs from UAB

The opioid epidemic started in the early 1990s with the rise of prescription overdoses. In more recent years, heroin and fentanyl use has rapidly increased. Fentanyl, specifically, is 50 to 100 times more potent than morphine. To keep up with the ever-evolving epidemic, the Randox MultiSTAT was validated for use in the medical examiner autopsy suite for the potential to aid medical examiners in triaging the need for a full autopsy versus an external examination with toxicology testing. The Randox MultiSTAT is a triage tool and investigatory screen designed to provide presumptive test results across multiple matrices. It can detect …

Optimizing Tomato Seedling Growth With Indigenous Mangrove Bacterial Inoculants And Reduced Npk Fertilization, Soumaya Tounsi-Hammami, Munawwar Ali Khan, Aroosa Zeb, Aneesa Rasheed Anwar, Naman Arora, Muhammad Naseem, Sunil Mundra

All Works

The search for ecofriendly products to reduce crop dependence on synthetic chemical fertilizers presents a new challenge. The present study aims to isolate and select efficient native PGPB that can reduce reliance on synthetic NPK fertilizers. A total of 41 bacteria were isolated from the sediment and roots of mangrove trees (Avicennia marina) and assessed for their PGP traits under in vitro conditions. Of them, only two compatible strains of Bacillus species were selected to be used individually and in a mix to promote tomato seedling growth. The efficiency of three inoculants applied to the soil was assessed in a …

Prevalence Of Premenstrual Syndrome And Its Associations With Dietary And Other Lifestyle Factors Among University Female Students In Dubai: A Cross-Sectional Study, Haleama Al Sabbah, Noof Al Mutawa, Enas A. Assaf

All Works

Background: Premenstrual syndrome is a relatively prevalent condition that affects a significant number of menstruating women worldwide. It can range from mild to severe and may interfere with daily activities. Objective: This study aims to investigate the prevalence of premenstrual syndrome and its associated factors among female university students in Dubai. Design: This study was designed as a cross-sectional study. Methods: The analysis for this study involved 217 female university students (aged ⩾18 years old) who completed a self-reported online questionnaire. Participants were recruited through simple random sampling, and the study received ethical approval from the Zayed University Ethical Committee. …