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Temperature Driven Variability In Bull Kelp (Nereocystis Luetkeana) Early Life Stages: A Comparative Study Of California Populations, Marzia Fattori

Cal Poly Humboldt theses and projects

This study investigated the effects of elevated temperatures on the reproductive and developmental stages of Nereocystis luetkeana, a crucial brown macroalgae found along the western coast of North America. My objectives were to 1) evaluate the impact of increasing temperature on the abundance of gametophytes from various sites, 2) determine the length of gametophytes that were affected by temperature on day 10 of culture, 3) assess the presence or absence of oocytes, sporophytes (young vs. multicellular), and abnormal cells, to understand the reproductive and stress responses to higher temperatures, and 4) determine if there is variation among early developmental …

Analyzing Science Classroom Design Ideas Of High School Students: Variations Amongst Lgbt-Identifying Students, Abraham A. Lewis

Cal Poly Humboldt theses and projects

The physical design of science classrooms is a leading factor in determining the uses of the classroom and the comfort and engagement of students in the classroom, and if a science classroom is designed with only the majority of students or the average student in mind, the classroom design may have a negative impact on the comfort, engagement, and perceptions of minority groups of students, such as queer students. The purpose of this research is to identify how a science classroom’s design impacts the perceptions, engagement, and comfort of queer students, and to use student suggestions to identify science classroom …

Interactions Between New Zealand Mud Snails (Potamopyrgus Antipodarum) And Toxic Cyanoabacteria (Anabaena) In Baduwa’T (Mad River), Humboldt County, California, Cecilia F. Kennelly

Cal Poly Humboldt theses and projects

Invasive species in freshwater systems are circulated around the globe, wreaking havoc on natural communities. The New Zealand mud snail (Potamopyrgus antipodarum) is a very successful aquatic invader that has established populations in freshwater streams, lakes, and rivers around the globe. The goal of this project was to evaluate the interactions of invasive New Zealand mud snails (NZMS) and toxic cyanobacteria Anabaena in the Mad River in Humboldt County, California. These two species of concern are found in similar habitats along the river, but their whether NZMS consume Anabaena or affect toxin production is unknown. First, I conducted …

Risk Of Depression In Persons With Alzheimer's Disease: A National Cohort Study, Casey Crump, Weiva Sieh, Barbara G Vickrey, Alexis C Edwards, Jan Sundquist, Kristina Sundquist

Faculty, Staff and Student Publications

INTRODUCTION: Depression is a risk factor and possible prodromal symptom of Alzheimer's disease (AD), but little is known about subsequent risk of developing depression in persons with AD.

METHODS: National matched cohort study was conducted of all 129,410 persons diagnosed with AD and 390,088 with all-cause dementia during 1998-2017 in Sweden, and 3,900,880 age- and sex-matched controls without dementia, who had no prior depression. Cox regression was used to compute hazard ratios (HRs) for major depression through 2018.

RESULTS: Cumulative incidence of major depression was 13% in persons with AD and 3% in controls. Adjusting for sociodemographic factors and comorbidities, …

A Qr Code For The Brain: A Dynamical Systems Framework For Computing Neurophysiological Biomarkers, William Bosl, Michelle Bosquet Enlow, Charles Nelson

Nursing and Health Professions Faculty Research and Publications

No abstract provided.

N Y State Dent J January 2024

The New York State Dental Journal

In the January 2024 issue, the reader will find the following feature articles:

• When One Door Closes, Another Opens
• Oral Manifestations of Metastatic Diseases: A Clinical and Histologic Analysis of Seven Cases
• Dentistry Transformed: An Overview of Artificial Intelligence’s Role in Dental Care
• Unlocking the Future of Dentistry: A Summary of AI and Augmented Intelligence in Dentistry from ADA’s White Paper
• Diagnostic Detail: Understanding the Impact of Tooth Rotation in Correcting Mucogingival Defects

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and …

Beside Marriage Equality: Conversations On Supriyo, Danish Sheikh, Rupali Samuel

Socio-Legal Review

This case comment takes the form of an epistolary exchange between the authors as they reflect on the Indian Supreme Court’s 2023 judgment in Supriyo @ Supriya Chakraborty & Anr v Union of India, which denied the existence of a constitutional right to marriage and deferred the responsibility of legalising same-sex marriage to the legislature. Through a staged conversation, the comment explores personal subject positions, legal frameworks, and the intricate entanglements of intimacy and state recognition. The authors consider how the law leaves imprints on our bodies and, in turn, how our embodied lives reshape the law through acts …

Optimizing Microbe-Infected Mosquito Release: A Stochastic Model For Malaria Prevention, Steeven Belvinos Affognon, Henri E.Z. Tonnang, Philip Ngare, Benard Kipchumba Kiplangat, Shirley Abelman, Jeremy K. Herren

All Peer-Reviewed Publications

Malaria remains a critical public health challenge in Africa, demanding innovative control strategies. This study introduces a novel approach using Microsporidia MB-infected mosquitoes and stochastic optimal control within a Lévy process framework to regulate mosquito release strategies. The primary goal is to optimize Microsporidia MB prevalence within mosquito populations to disrupt Plasmodium transmission to humans. By incorporating Lévy noise into the modeling process, we capture the inherent randomness of mosquito dynamics, improving intervention accuracy. The model, guided by the Hamilton–Jacobi–Bellman (HJB) equation, optimizes release protocols while accounting for key environmental factors like seasonality and temperature fluctuations. Results show that intervention …

Immunomodulatory Activity Of Different Polyphenolic Compounds Isolated From Origanum Majorana, Doaa G. El-Hosari, Nermine M. Mohammd, Mohamed F. Barghash, Mohamed I. S. Abdelhady, Reham R. Ibrahim

Trends in advanced sciences and technology

Growing in many Mediterranean nations since antiquity, Origanum majorana L. is an aromatic herb that gained popularity as a spice and medicinal plant during the Middle Ages. Although O. majorana possesses a wide range of pharmacological effects, its immunoreactive components and mechanisms remain unknown. In this study, six compounds were isolated and identified from O. majorana. The isolated compounds were identified on the basis of acid hydrolysis, comparative PC, UV, ESI-MS, 1H- and 13C-NMR spectroscopic analysis and comparing with authentics and previous reported data. The compounds were identified as Cinnamic acid, Gallic acid, Caffeic acid, PCoumaric acid, Apigenin and Luteolin. …

Evaluation Of The Diagnostic Performance Of Nucleocapsid Antigen For Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Doaa Fathy Ahmed, Amal Ahmed Mohamed, Manar S. Fouda, Sara A. Mekkawy, Randa Ibrahim Ahmed, Omar Mohamoud Azzam, Doaa Ghaith, Ahmed El-Kasses, Mostafa Omran

Trends in advanced sciences and technology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) was identified as the aetiological agent of coronavirus disease 2019 (COVID-19). The SARS-COV-2 genome encodes four structural proteins include spike (S) protein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein. nucleocapsid protein is one of the predominantly expressed structural proteins and has been confirmed as an ideal target for early diagnostic detection in SARS-COV-2 infection. In the current study, the diagnostic performance of Nucleocapsid antigen in severe acute respiratory syndrome Coronavirus 2 infected individuals is evaluated in Egypt. Patients and Methods: All human individuals’ samples (n= 106) were collected from El …

Synthesis, Anticancer Activity And Docking Study Of Novel Benzo[H]Quinoline Derivatives, Marwa A. Khodair, Mosaad S. Mohamed, Samir M. Awad, Rania H. Abd El-Hameed

Trends in advanced sciences and technology

Background: Benzo[h]quinolines have attracted a lot of interest because of their biological characteristics, especially their capacity to impede cell proliferation, for this reason it is essential to utilize their high activity for new, powerful anti-cancer agents’ discovery. Objective: The main objectives are to synthesize de-novo benzo[h]quinolines and fused analogues then evaluate their anti-cancer activities. Methods: Our target compounds 1a-d were prepared through Knoevenagel condensation followed by Michael addition. Compounds 1a-d were further cyclized via reactions with different reagents particularly, formic acid, formamide, acetic anhydride and carbon disulfide to obtain fused derivatives 2-5 (a-d) respectively. Structures …

Green Flow-Gradient Micellar High Performance Liquid Chromatograpic Method For Determination Of A Hypertensive Combination ; Azilsartan Medoxomil And Chlorthalidone :Application To Spiked Human Plasma And Urine, Maha M. Abou El-Alamin, Maha A. Sultan, Dina A Mohamed, Marwa M. Azab

Trends in advanced sciences and technology

A green novel cost effective flow-gradient micellar high performance liquid chromatographic method was developed and validated for the simultaneous determination of two antihypertensive drugs,Azilsartan Medoxomil (AZL) and chlorthalidone (CLT) in plasma and urine. The eco-friendly method showed good linearity over the ranges of 15.00-80.00 µg/mL and 12.50-62.50 µg/mL with limits of detection (LOD) of 0.19, 0.12 µg/mL and limits of quantification (LOQ) of 0.59, 0.36 µg/mL for AZL and CLT, respectively. The proposed method was successfully applied for the simultaneous analysis of the studied drugs in their single tablets, laboratory mixed tablets in human plasma and urine without prior extraction …

Dual Activity Of Aromatic And Heterocyclic Compounds As Anti-Inflammatory And Anticancer Promising Agents, Samar Said Fatahala, Rania Helmy Abd El-Hameed, Mosaad Sayed Mohamed, Neama Abdallah Abd El-Tawab

Trends in advanced sciences and technology

As the second leading cause of mortality worldwide, cancer poses a severe threat to human health. Chronic inflammation has recently been linked to an increased risk for a number of malignancies, suggesting that reducing inflammation could be a useful approach to both cancer prevention and treatment. This review delves into the connection between inflammation and cancer and outlines the current use of anti-inflammatory drugs as potentially effective cancer prevention and therapy strategies. we herein describe the main relation and the mechanisms underlying the anti-cancer outcomes of anti-inflammatory agents; namely Non-Steroidal Anti-inflammatory Drugs (NSAIDs), COX-2 inhibitors, LOX-inhibitors, Toll- inhibitors, and antioxidant …

The Decline Of Science In The Early Years: A Diagnosis And A Plan Of Action, Jennifer Bentley

University of the Pacific Theses and Dissertations

Science instruction in the early years of a student’s education career is essential to a student successfully continuing science in their secondary and postsecondary careers. However, the amount of high-quality science instruction students receive at the elementary level has been steadily declining for two decades, resulting in an inequitable imbalance in those who pursue STEM careers, a lack of critical science literacy in the U.S. populace, and a shortage of qualified employees entering the U.S. economy. Much of the lack of science instruction can be traced to decreased training of teachers to teach science during elementary credentialing programs or the …

Exploring The Relative Contribution Of Humans On Genetic Differentiation Among Speyeria Callippe Populations In The California Coast Ranges, Laura K. Heller

University of the Pacific Theses and Dissertations

The distinction between populations due to environmental factors like climate and geography are well-known and expected, therefore it is not illogical to believe more disjunct habitats would also impact genetic structure. Through Restriction Site Associated DNA Sequencing (RADseq) and Mitochondrial DNA (mtDNA) analysis the genetic structure and differentiation (fixation index, Fst) of Speyeria callippe across four regions in California: the North Coast Ranges, Bay Area, Diablo Range, and South Coast Ranges were analyzed. The influence of geographic distance, human population density, and forest cover were explored as factors influencing the genetics of these populations. The combination of mtDNA and RADseq …

Quantitative Shotgun Proteomic Analysis Of Bacteria After Overexpression Of Recombinant Spider Miniature Spidrion, Masp1, Kathryn P. Randene

University of the Pacific Theses and Dissertations

Spider silk has extraordinary mechanical properties, displaying high tensile strength, elasticity, and toughness. Given the high performance of natural fibers, one of the long-term goals of the silk community is to manufacture large-scale synthetic spider silk. This process requires vast quantities of recombinant proteins for wet-spinning applications. Attempts to synthesize large amounts of native size recombinant spidroins in diverse cell types have been unsuccessful. In these studies, we design and express recombinant miniature black widow (Latrodectus hesperus) MaSp1 spidroins in bacteria that incorporate the NTD and CTD, along with varying numbers of codon-optimized internal block repeats. Following spidroin overexpression, we …

Structural And Functional Studies Of The Human Members Of The Macrophage Migration Inhibitory Factor Family, Andrew Parkins

University of the Pacific Theses and Dissertations

Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT) are the two human members of the MIF superfamily, which are implicated in an array of autoimmune disorders, inflammatory diseases, and cancer via their pleiotropic functionality. Despite only sharing 34% sequence identity, MIF and D-DT have high structural homology and overlapping functional traits, including activation of the type II cell surface receptor CD74 and keto-enol tautomerase activity. The MIF and/or D-DT-induced activation of CD74 leads to signaling cascades pivotal for cell growth, proliferation, and inhibition of apoptosis. Such characteristics make MIF and D-DT attractive molecular targets for drug discovery.

Currently, all …

Elaboration Of Diquinanes To Access Trifunctional Angular Triquinanes And Designed Dna Polymerase Α Inhibitors, Spencer M. Webber

University of the Pacific Theses and Dissertations

Natural products are of great significance to the pharmaceutical industry in the development of new drugs. Diquinane or bicyclo[3.3.0]octane is a conspicuous structural unit existing in the carbo-frameworks of a wide range of natural products such as alkaloids and terpenoids. These diquinane-containing molecules not only exhibit intriguing architectures, but also showcase a broad spectrum of significant bioactivities, which draw widespread attention from the global synthetic community. A more specific group of compounds containing a diquinane moiety with one extra 5-membered ring are called the angular triquinanes.In this work, we have developed a general synthetic scheme to the angular triquinanes. We …

From Elementary School To Doctoral Education: An Autoethnographic Journey, Gwendolyn D. Dailey

University of the Pacific Theses and Dissertations

Every child has a right to education, and their skin color should not determine their education quality. However, since the landmark case of Brown v. Board of Education (1954), it has been proven that race continues to matter in the success and failure of education (Delgado & Stefancic, 2001). The persistent achievement gaps between students of different racial and ethnic backgrounds, as well as the disparities in access to high-quality educational opportunities, demonstrate how race and ethnicity shape the educational experiences of students of color (Stanford Center for Education Policy Analysis, 2012). Unfortunately, stories such as Ruby Bridges of New …

Effects Of Glyphosate-Based Herbicide Exposure On Life History, Stress Tolerance, And Microbiome—From Plasticity To Evolution, Jacob R. Whitlock

University of the Pacific Theses and Dissertations

Glyphosate (GLY) is the most used pesticide worldwide, and GLY-based herbicides (GBHs) can affect animals’ microbiomes and, in turn, their physiology and morphology. Environmental stressors can be mitigated by flexibility in life-history strategies, which can also dictate animal physiology and morphology. However, we lack an understanding of how GBH influences life-history strategies and stress tolerance, in addition to its effects across generations. Thus, I exposed the variable field cricket, Gryllus lineaticeps, to GBH within- and across-generations to examine the role of GBH in developmental plasticity and evolution. Specifically, I measured its effects on life-history traits (e.g., developmental duration and a …

Effects Of Fetal Bovine Serum On The Proteome And Secretome Of Pichia Pastoris, Kenneth L. Nguyen

University of the Pacific Theses and Dissertations

Komagataella pastoris, formerly known as Pichia pastoris, and hereafter referred to as Pichia, is a methylotrophic yeast widely employed as a recombinant protein factory for biotechnical and industrial purposes. P. pastoris boasts the ability to thrive at high cell densities, executes numerous post-translational modifications, and exhibits minimal secretion of endogenous proteins, thus greatly facilitating the expression and purification of recombinant proteins. Despite these advantages, Pichia still presents certain challenges as an expression system. Occasionally, recombinant proteins are retained within the cell and subject to degradation. Furthermore, Pichia falls short in matching the production capabilities of more widely used systems like …

The Role Of The Unfolded Protein Response In Fatty Liver Disease, Anusha L. Murshed

University of the Pacific Theses and Dissertations

The unfolded protein response (UPR) is composed of three highly conserved pathways (ATF6, IRE1, PERK). Cellular stressors induce protein misfolding and aggregation in the endoplasmic reticulum (ER). This signaling pathway maintains protein homeostasis when there is stress in the ER. When the UPR is activated, the eukaryotic initiation factor 2 alpha (eIF2α) becomes phosphorylated, which inhibits global mRNA translation. If ER stress remains chronically unmitigated, the UPR induces apoptosis. GADD34 and CReP shift in expression when the UPR is activated and work as phosphatases and dephosphorylate eIF2α in a feedback loop, allowing protein synthesis to resume. Several human diseases, including …

Insight Into A Sexually Dimorphic Ostracod Crustacean By Mass Spectrometry And Microtomography, Cindy D. Davis

University of the Pacific Theses and Dissertations

The importance of the central nervous system cannot be understated. An array ofmolecules associated with the brain regulate basic behaviors as well as sex specific behaviors. Describing the molecular background is not the only way that I can learn more of the central nervous system. Describing the anatomy of the central nervous system can be crucial in understanding what regions of the brain is particularly key to the animal. Euphilomedes carcharodonta is a small marine crustacean native to the subtidal zone of the California coast. This ostracod makes for a compelling candidate to explore these research interests as this organism …

Filipina American Mothers’ Experiences Obtaining Services For Their Children With Autism Spectrum Disorder, Nina Chelle Boling

University of the Pacific Theses and Dissertations

Autism spectrum disorder (ASD) is a multifaceted developmental condition that manifests in early childhood, affecting various aspects of neurologic, biological, adaptive, social, linguistic, and cognitive functions. A timely and accurate diagnosis of ASD is crucial for effective intervention, promoting personal and social growth, and fostering independent adulthood. However, obtaining this diagnosis can pose challenges, particularly for people of color, who often encounter disparities in healthcare access compared to their White counterparts. This study aims to investigate the experiences of Filipina mothers raising children with ASD, specifically focusing on their journey to access appropriate autism services.

As of 2019, there were …

Plasticity In Response To Temperature Magnitude And Variation---From Life History To Thermal Tolerance And Coloration, Austin Rex Hoffman

University of the Pacific Theses and Dissertations

Warming associated with climate change has many direct and downstream effects on animals. For example, warmer developmental temperatures can improve heat tolerance and reduce insect melanization, which is related to coloration, thermoregulation, immunity, desiccation resistance, and potentially life-history traits, such as investment into reproduction and dispersal. Increased temperature variation is also a feature of climate change, and it may have a larger impact on animals than warming. However, I lack insight into the combined effects of temperature magnitude and variability on important traits of life history, thermal tolerance, and coloration. Thus, I integrated temperature variation into thermal performance using a …

Transgenerational Effects Of Stress On The Plasma Proteome Of A Marine Mammal, Emily Voelkner

University of the Pacific Theses and Dissertations

The physiological stress response enables animals to respond to changes in their environment, and is mediated by the hypothalamic-pituitary-adrenal (HPA) axis in mammals. Increased activation of the HPA axis by repeated stress during critical life stages like reproduction could affect fitness. Information about a stressor can be communicated to offspring via hormone signals prenatally, or postnatally via milk, and affect offspring development and stress reactivity. Experimentally activating the HPA axis by adrenocorticotropic hormone (ACTH) administration results in the synthesis of the major glucocorticoid hormone cortisol, which has well-studied far-reaching effects on growth, metabolism, and immunity. Beyond cortisol levels alone, biomarkers …

Smu Welcomes Two New Members To Its Board Of Trustees, Singapore Management University

SMU Press Releases and News

The Singapore Management University is pleased to announce the appointment of two new members to its Board of Trustees with effect from 12 January 2024. Their appointment will be for an initial term of three years. The new members are: (1) Dr Andrew David Hamilton – President Emeritus, New York University, (2) Mr Don Lam – Chief Executive Officer & Founding Partner, VinaCapital Group.

Opioid Use Disorder In Missouri: An Evidence-Based, Public Health-Oriented Approach, Benjamin Grin

Faculty and Staff Publications

Opioid use disorder (OUD) represents a growing public health crisis in Missouri and nationwide. Reversing the trend of rising OUD-associated morbidity and mortality will require implementing evidence-based approaches grounded in public health principles. Key evidence-based interventions include medications for opioid use disorder, naloxone distribution, overdose education, and syringe services programs. The increasing presence of fentanyl and xylazine in the drug supply represent new challenges to the OUD crisis in Missouri. Optimal implementation of evidence-based interventions will require action at the individual physician, community, and state policy level.

Fretting Corrosion Wear Of Titanium-Based Alloy (Ti-6al-4v) In 0.9 Wt.% Nacl Solution, Chen-En Lu, Wen-Ken Li, Hung-Hua Sheu, Jeou-Long Lee, Hung-Bin Lee

Journal of Marine Science and Technology–Taiwan

In this study, a high precision fretting tribo-corrosion tester used to analyze the wear and corrosion behavior of Ti alloys in a fretting motion condition. The tester, operated in a ball-on-plate mode, was employed in the fretting corrosion study of metallic bio-materials (Ti and Ti-6Al-4V) under different loads (0 and 10 N), electrolytes (0.9 wt% NaCl and SBF) and fixed displacement frequency (1 Hz). Using profilometer, optical microscope in the experimental analysis and three-body mechanism in the theoretical analysis, the fretting corrosion performances of these bio-medical metals, such as velocity accommodation characteristics, friction, wear, and scratch profile were examined in …

A New-Type Deep Learning Model Based On Shapley Regulation For Containerized Freight Index Prediction, Yen-Chang Shih, Ming-Shue Lin, Taih-Cherng Lirn, Jih-Gau Juang

Journal of Marine Science and Technology–Taiwan

In this study, we have crafted an innovative methodology that represents a groundbreaking synthesis of deep learning techniques with cooperative game theory. In this study, we use the accuracy of data prediction by different LSTM models as a measurement index and assign different LSTM models corresponding weights through the Shapley value calculation method to construct a more accurate predictive analysis model. We use this improved Shapley regulation model to calibrate a long short-term memory (LSTM) neural network by using historical freight data to predict the China Container Freight Index (CCFI), the leading export container freight index commonly used in China. …