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Revisiting The Global Measures Of Overall Neuropsychological Function And The Impact Of Race-Based Normative Data In Clinical And Forensic Populations, Zachary Thomas Dipasquale

PCOM Psychology Dissertations

This research investigated the impact of race-based normative data, the removal of a subtest, and the reason for referral on neuropsychological assessments. Three hypotheses were tested using various statistical methods. The first hypothesis predicted a significant difference in the Average Impairment Rating (AIR) when comparing European American normative data to African American normative data. The second hypothesis posited that the removal of the 12th composite score (Av-1) would significantly alter the classification of brain injury using the AIR. The third hypothesis proposed that a significant difference would be observed in the AIR, General Deficit Scale (GDS), and Halstead Impairment Index …

Influence Of Reduced Salt In Fully Cooked Ham And Sausage Cured With Natural Celery Powder On The Growth Of Listeria Monocytogenes At 4⁰C, Anne Sherod

Electronic Theses and Dissertations

This research evaluated the influence of reducing salt on outgrowth of L. monocytogenes on ready to eat (RTE) deli-style sliced ham cured with natural celery powder, fully cooked sausage links cured with traditional sodium nitrite and sausage links cured with natural celery powder, vacuum packaged and stored at 4⁰C on the outgrowth of L. monocytogenes. Experiment 1 evaluated L. monocytogenes outgrowth on ham over 153 days on the following treatments, current retail ham (HC) 2.0% salt; reduced salt 1 (HRS1) 1.5% salt; reduced salt 2 (HSR2) 1.35% salt; and reduced salt 2 without antimicrobials (HRS2WA) 1.35% salt without potassium lactate …

Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada

Electronic Theses and Dissertations

Leishmaniasis is a protozoan parasitic disease caused by the species Leishmania that affects millions of people around the world. It is a serious public health concern in the developing world with about 1 million cases and 70,000 fatalities occurring each year. It has several forms with visceral, and cutaneous leishmaniasis being the most common forms of the disease. Visceral leishmaniasis, caused by the Leishmania donovani occurs mainly in Brazil, Eastern Africa, and India, and is fatal if left untreated. The current treatments for leishmaniasis such as pentavalent antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and some azoles suffer from serious drawbacks. …

Various Surfactant Soil Conditioner Effect On Plant Nutrient Concentration, Soil Nutrient Depletion, Soil Volumetric Water Content, Plant Biomass And Yield In Corn, Timothy Veldkamp

Electronic Theses and Dissertations

Soil conditioners help improve soil structure by increasing aeration, water infiltration and water holding capacity leading to nutrient availability and reduced irrigation needs. The goal of this study was to evaluate the impact of multiple soil conditioners (SC1, SC2, SC3, SC4, and SC5) on corn (Zea mays L.) and their ability to reduce irrigation by 30%. This was evaluated in the field in 2022 and 2023 by Aurora, SD using a Randomized Complete Block Design with six replications. Conditioners were applied as broadcast pre-emergence treatments with 70% irrigation. Control treatments of 70% and 100% irrigation, respectively were included. SC1 application …

Impact Of Varying Molecular Weights Of Hyaluronic Acid On The Functional Properties Of Process Cheese Product, Rutvi Joshi

Electronic Theses and Dissertations

Hyaluronic acid (HA) is being accepted for use as a food ingredient and/or food supplement. It is available in a wide range of molecular weights (MW) and represents unique moisture retention properties depending on the MW. The moisture retention property of HA would be of great economic potential for the dairy industry. HA is a natural polysaccharide and holds the potential as a functional ingredient in dairy and food applications to modify viscosity and textural properties. The first research objective of the study was to determine the impact of very low to high MW of HA - 8kDa, 320kDa, 980kDa, …

Role Of Production Systems On Carcass And Palatability Attributes Of Bison, Lydia Margaret Hite O'Sullivan

Electronic Theses and Dissertations

The overall objective of this dissertation was to determine the impact of finishing systems on carcass and palatability attributes of bison. The specific objectives were 1) determine the influence of finishing system (grain-finished vs. grass-finished) on the mechanisms of tenderness formation in the longissimus lumborum of bison bulls, 2) determine the influence of diverse finishing systems on carcass characteristics and proximate composition of bison heifers, and 3) determine the influence of diverse finishing systems on palatability of striploin steaks from bison heifers. Results indicate that finishing systems differentially influence carcass characteristics, tenderness, and flavor attributes of bison. Specifically, this is …

Optimizing Large Language Models And Multimodal Approaches For Biomedical Publication And Satellite Imagery, Youngsun Jang

Electronic Theses and Dissertations

This dissertation comprises two main sections: the first focuses on natural language processing (NLP) for extracting key information from scientific literature using large language models (LLMs), and the second addresses remote sensing for detecting natural disasters, such as floods, from satellite imagery using a multimodal approach. The first section investigates methods to enhance Transformer-based models in classifying and extracting information from biomedical scientific publications. Key contributions include the development of a custom dataset for classification and Question and Answering (Q&A) tasks, fine-tuning Transformer models like the Bidirectional Encoder Representations from Transformers (BERT) and addressing multi-span answer issues with the TAg-based …

Genetic And Ecologic Effects Of Seed Dormancy Genes On Seed Aging, Soil Seedbank Longevity, And Microbiome In An Isogenic Background Of Rice ( Oryza Sativa L.), Bhupinder Singh Batth

Electronic Theses and Dissertations

No abstract provided.

Whole Genome Crispr-Cas9 Screens Identify Genes Contributing To Viral Entry And Phagocytosis, Md Saddam Hossain

Electronic Theses and Dissertations

CRISPR/Cas9 is a revolutionary technique for genome editing where Cas9 nucleases can be targeted to specific genomic sites by single-guide RNAs (sgRNAs) containing roughly 20-nucleotide sequences that are complementary to the target region. Double strand breaks created by Cas9 are repaired through non-homologous end-joining (NHEJ) in most cells, resulting in insertions and deletions leading to frame shift mutations in coding regions. Thus, the CRISPR-Cas9 system can be exploited for systematic evaluation of gene function relationships by whole genome screening. We also developed a CRISPR whole‐genome screen and counter‐screen strategy based on a pseudoviral platform that allowed identification of genes specific …

Impacts Of Starter Fertilizer On Corn Development, Nutrient Uptake And Grain Yield In Eastern South Dakota, Larousse Dorissant

Electronic Theses and Dissertations

Cold and wet spring conditions during planting in the Northern Corn Belt can limit nutrient mobility, especially phosphorus (P) due to reduced mineralization. This often triggers the use of starter fertilizers to enhance nutrient availability within the root zone, and as a result improve nutrient uptake and the overall plant growth. Albeit research has shown that starter fertilizer applications can significantly boost corn grain yield potential, the most substantial yield responses from starter fertilization are typically observed in fields where soil test P levels fall below the critical soil test P threshold. This dissertation explores i) the effects of starter …

Analysis Of Toxic Chemical Agents And Therapeutics For Toxic Inhaled Agents’ Exposure, Khadija Bilkis

Electronic Theses and Dissertations

When inhaled, toxic inhalation agents (TIAs) such as cyanide (CN), ammonia and sulfur compounds (e.g. methanethiol (MeSH)) can be fatal. Many TIAs cause cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, neurodegenerative disorder, circulatory collapse, seizures, and potential death by blocking mitochondrial cytochrome c oxidase. All TIA’s have the potential to be employed as chemical warfare agents, terrorist weapons, or dangerous occupational gases. Although many TIAs are potential threats, there are minimal FDA-approved treatments for these substances useful in a mass-casualty situation. Recently, cobinamide (Cbi) has come to light as a potential antidote for MeSH poisoning. However, methods for analyzing MeSH …

ผลของโปรแกรมการจัดการอาการร่วมกับการควบคุมความโกรธต่อพฤติกรรมก้าวร้าวของผู้ป่วยจิตเภท, พรประภา เหล็กกล้า

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้เป็นการวิจัยแบบกึ่งทดลองศึกษาแบบสองกลุ่มวัดผลก่อนและหลังการทดลอง มีวัตถุประสงค์เพื่อเปรียบเทียบพฤติกรรมก้าวร้าวของผู้ป่วยจิตเภทก่อนและหลังได้รับโปรแกรมการจัดการอาการร่วมกับการควบคุมความโกรธ และเปรียบเทียบพฤติกรรมก้าวร้าวระหว่างกลุ่มที่ได้รับโปรแกรมการจัดการอาการร่วมกับการควบคุมความโกรธ กับกลุ่มที่ได้รับการพยาบาลตามปกติ กลุ่มตัวอย่าง คือ ผู้ป่วยจิตเภทที่เข้ารับการรักษาในแผนกผู้ป่วยใน โรงพยาบาลสวนสราญรมย์ จำนวน 50 คน โดยใช้วิธีการเลือกกลุ่มตัวอย่างแบบเจาะจง เพื่อคัดกรองให้ได้กลุ่มเป้าหมายที่ต้องการศึกษาและควบคุมความแปรปรวน แล้วนำมาจับสลากหากลุ่มควบคุมและกลุ่มทดลอง หลังจากนั้นคัดเลือกผู้ป่วยที่มีคุณสมบัติตามเกณฑ์การคัดเข้า และจับคู่ที่มีลักษณะคล้ายคลึงกันในด้านเพศ และ คะแนนทางบวก แบ่งเป็นกลุ่มทดลอง 25 คน กลุ่มควบคุม 25 คน กลุ่มทดลองได้รับกิจกรรมการจัดการอาการร่วมกับการควบคุมความโกรธ กลุ่มควบคุมได้รับการพยาบาลตามปกติ เครื่องมือวิจัยประกอบด้วย โปรแกรมการจัดการอาการร่วมกับการควบคุมความโกรธ แบบบันทึกข้อมูลส่วนบุคคล แบบประเมินพฤติกรรมก้าวร้าว (KR-20 = .85) แบบวัดการแสดงความโกรธ (α = .81) และแบบประเมินความสามารถในการจัดการกับอาการทางบวก (α = .82) และแบบประเมินอาการทางบวก (α = .83) ซึ่งผ่านการตรวจสอบความตรงเชิงเนื้อหาโดยผู้ทรงคุณวุฒิจำนวน 5 ท่าน มีค่าความตรงเชิงเนื้อหาเท่ากับ 1 (CVI = 1.00) วิเคราะห์ข้อมูลโดยใช้ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และสถิติค่าที ผลการวิจัยสรุปได้ ดังนี้ 1. ค่าเฉลี่ยคะแนนพฤติกรรมก้าวร้าวของผู้ป่วยจิตเภทของกลุ่มทดลองภายหลังได้รับการจัดการอาการร่วมกับการควบคุมความโกรธต่ำกว่าก่อนได้รับการจัดการอาการร่วมกับการควบคุมความโกรธ อย่างมีนัยสำคัญทางสถิติที่ระดับ .05 2. ค่าเฉลี่ยคะแนนพฤติกรรมก้าวร้าวของผู้ป่วยจิตเภทที่เข้าร่วมโปรแกรมการจัดการอาการร่วมกับการควบคุมความโกรธต่ำกว่าผู้ป่วยจิตเภทที่ได้รับการพยาบาลตามปกติ อย่างมีนัยสำคัญทางสถิติที่ระดับ .05

[Ordered] Liberty And Justice For All? The Elusive "Right To Privacy" And A Comparison Of American And Canadian Women's Rights Schemes, Caroline Wakefield

South Carolina Journal of International Law and Business

No abstract provided.

Association Of Genetic Polymorphisms With Clinical Characteristics And Survival Of Hepatocellular Carcinoma Patients With Or Without Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld), Theint Cho Zin Aung

Chulalongkorn University Theses and Dissertations (Chula ETD)

The influence of single-nucleotide polymorphisms (SNPs) on hepatocellular carcinoma (HCC) in terms of etiological factors remains to be explored. This study evaluated the distribution of PNPLA3 rs738409, TM6SF2 rs58542926, and HSD17B13 rs6834314 and overall survival of HCC patients with metabolic dysfunction-associated steatotic liver disease (MASLD-HCC) and viral-related HCC (VIRAL-HCC). In this study, 564 patients with HCC were included: 254 with MASLD-HCC and 310 with VIRAL-HCC. The SNPs were determined by real-time PCR using TaqMan assays. Results: The mean ages of patients with MASLD-HCC and VIRAL-HCC were 68.4 vs. 60.9 years (p < 0.001), with a significant difference between groups. The prevalence of PNPLA3 genotype GG in MASLD-HCC was significantly higher in MASLD-HCC than in VIRAL-HCC (24.0 % vs. 15.5%; OR = 1.86; 95% CI = 1.14–3.05; p = 0.009). Similarly, the prevalence of TM6SF2 genotype TT in MASLD-HCC and VIRAL-HCC was 7.1% vs. 2.6% (OR = 3.39; 95% CI = 1.36–9.21; p = 0.003), while HSD17B13 genotype GG in the corresponding groups was 7.1% vs. 12.6% (OR = 0.53; 95 % CI = 0.27–1.01; p = 0.039). The overall median survival of MASLD-HCC was significantly shorter than the VIRAL-HCC group (42 vs. 66 months; p = 0.035). In Cox regression hazard analysis, HSD17B13 GG genotype was significantly associated with a lower mortality rate in MASLD-HCC (HR = 0.38 ; 95% CI = 0.18–0.81; p = 0.011). In contrast, PNPLA3 and TM6SF2 were not associated with overall survival in patients with MASLD-HCC or VIRAL-HCC. Conclusions: These data demonstrated that the prevalence of the studied SNPs significantly differed between MASLD-HCC and VIRAL-HCC. The HSD176B13 GG genotype was also associated with a survival benefit in Thai patients with MASLD-HCC.

Crosstalk Between Cytokines And The Diverse Pattern Of Tumor Immune Microenvironment (Time) In Egfr Mutant Advanced Stage Non-Small Cell Lung Cancer Receiving Egfr Tyrosine Kinase Inhibitor, Sorawich Kuendee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Although EGFR-TKI therapy significantly improves outcomes in patients with EGFR-mutant advanced NSCLC, inter-individual variability in treatment response remains a major challenge. One potential contributing factor is the tumor immune microenvironment (TIME), which plays a critical role in tumor behavior and may influence therapeutic efficacy. However, the relationship between baseline cytokine profiles and TIME features in this patient population remains unclear. Methods: Prospective observational study involving patients with advanced EGFR-mutant NSCLC receiving first-line EGFR-TKI therapy. Baseline cytokine levels were measured using the Bio-Plex Pro™ Human 27-Plex Cytokine Assay. Immunohistochemistry was used to evaluate CD8⁺ TILs and PD-L1 expression. The primary …

Roles Of Mtor Complex 2 Signaling In The Sphingolipid Production Of Brain Cancer Cell Lines, Nuanwan Songcharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Gliomas, which include low- and high-grade types, represent a particularly aggressive form of primary brain tumor, especially glioblastoma (GBM). Metabolic reprogramming in lipid metabolism supports cell proliferation; alterations in the sphingolipid pathway, elevated glucosylceramide (GlcCer) levels through glucosylceramide synthase (GCS), promote the production of glycosphingolipids, which serve as building blocks for cancer cells. Furthermore, mTORC2, which is a kinase protein, contributes to lipid metabolism. Thus, the study aims to investigate the roles of mTORC2 signaling in lipid metabolism through lipid accumulation, which was reduced with AZD8055 treatment as the mTORC2 inhibitor. Additionally, p-AKT (S473), which is downstream of mTORC2, was …

Effect Of Task Constraints On Neurobiological Systems Involved In Postural Control In Individuals With And Without Chronic Ankle Instability, Yuki A. Sugimoto, Patrick O. Mckeon, Christopher K. Rhea, Carl G. Mattacola

Rehabilitation Sciences Faculty Publications

The purpose of this study is to investigate the effect of task constraints on the neurobiological systems while maintaining postural control under various sensory feedback manipulations in individuals with and without Chronic Ankle Instability (CAI). Forty-two physically active individuals, with and without CAI, were enrolled in a case-control study conducted at a biomechanics research laboratory. All participants underwent the Sensory Organization Test (SOT), which assesses individuals’ ability to integrate somatosensory, visual, and vestibular feedback to maintain postural control in double-, uninjured-, and injured-limb stances under six different conditions in which variations in the sway-referenced support surface (platform) and visual surroundings, …

Perception, Awareness, And Practices Toward The Pm2.5 During The Air Pollution Episode Among Chinese Students In Bangkok And Vicinity, Thailand: A Cross-Sectional Study, Jiali Chen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Air pollution poses a significant public health threat to urban populations worldwide. Mobile groups such as international students face unique vulnerabilities, but their risk adaptation capacity remains understudied. This study assessed awareness, perception, and protective measures of PM2.5 among Chinese international students in Bangkok and its vicinity. This study used a validated scale to conduct a cross-sectional survey of 393 participants. The results revealed that while students exhibited a high level of risk perception regarding air pollution (mean score: 48.0 ± 7.6), their awareness was relatively low (mean score: 6.3 ± 2.9), with only 3.8% of respondents demonstrating "high awareness". …

Effects Of Water Chemistry On Interaction Between Organic Contaminants And Microplastics And Their Passage In Microfiltration Membrane, Chutiporn Inchana

Chulalongkorn University Theses and Dissertations (Chula ETD)

The agricultural activity is a critical source of organic contaminants and microplastics (MPs). Typically, the agricultural soil is contaminated by an abundance of MPs, leaching chemicals during weathering process, and pesticides, which subsequently end up in surface water through agricultural runoff. Polymers that are most frequently used in crop production and detected in surface water are PE and PET MPs. Bisphenol (A) and atrazine are frequently detected in surface water. Nevertheless, the fate and distribution of organic pollutants in water treatment as a consequent on MP-aided transport is constrained by little knowledge on photoaged PE and PET MPs. In this …

การพัฒนารูปแบบการเรียนรู้โมไบล์เลิร์นนิงแบบสืบสอบโดยใช้ปัญญาประดิษฐ์แบบรู้สร้างในการจับกลุ่มร่วมคิดเพื่อส่งเสริมการคิดอย่างมีวิจารณญาณของนักเรียนมัธยมศึกษาตอนปลาย, ธรรมทัศน์ สิงห์กา

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อ 1) ศึกษาสภาพความเป็นจริง สภาพที่คาดหวัง และความต้องการจำเป็นในการพัฒนารูปแบบการเรียนรู้โมไบล์เลิร์นนิงแบบสืบสอบโดยใช้ปัญญาประดิษฐ์แบบรู้สร้างในการ จับกลุ่มร่วมคิดเพื่อส่งเสริมการคิดอย่างมีวิจารณญาณของนักเรียนมัธยมศึกษาตอนปลาย จากครูผู้สอนในกลุ่มสาระวิทยาศาสตร์และเทคโนโลยี ระดับชั้นมัธยมศึกษาตอนปลาย จำนวน 390 คน 2) พัฒนารูปแบบการเรียนรู้ฯ โดยสัมภาษณ์ความคิดเห็นผู้เชี่ยวชาญ จำนวน 5 คน 3) ศึกษาผลการใช้รูปแบบการเรียนรู้ฯ กับนักเรียน ชั้นมัธยมศึกษาปีที่ 4 จำนวน 34 คน ผลการวิจัยพบว่า . 1) สภาพความเป็นจริงในการพัฒนารูปแบบการเรียนรู้ฯ อยู่ในระดับมาก ค่าเฉลี่ยสูงสุด คือ ผู้สอนมีการแสดงให้เห็นถึงการเอาใจใส่ ให้คำชมเชย และเสริมแรงให้กับผู้เรียน (x̄ = 4.17, SD = 0.72) สภาพที่คาดหวังอยู่ในระดับมากที่สุด ค่าเฉลี่ยสูงสุด คือ ผู้สอนนำอุปกรณ์ อิเล็กทรอนิกส์ เข้ามาใช้ในการจัดการเรียนการสอน และผู้สอนมอบหมายงานได้สอดคล้องกับเนื้อหาบทเรียน (x̄ = 4.67, SD = 0.54) และความต้องการจำเป็นในการพัฒนารูปแบบการเรียนรู้ฯ ลำดับที่ 1 คือ ด้านการจัดกิจกรรมการเรียนการสอน ผู้สอนมอบหมายให้ผู้เรียนศึกษาเนื้อหาผ่านสื่อวิดีโอนอกชั้นเรียนก่อนทำกิจกรรมการเรียนการสอนในชั้นเรียน (PNIModified = 0.23) 2) รูปแบบการเรียนรู้ฯ ประกอบไปด้วย 6 องค์ประกอบ คือ ระบบจัดการเรียนรู้ที่สนับสนุนการเรียนผ่านอุปกรณ์เคลื่อนที่ เทคโนโลยีสนับสนุน ผู้อำนวยการเรียนรู้ ผู้เรียน กิจกรรมการเรียนรู้สืบสอบร่วมด้วยปัญญาประดิษฐ์แบบรู้สร้าง และการประเมินผล โดยมี 5 ขั้นตอน คือ (1) กระตุ้นความสนใจร่วมกับกิจกรรมคิดเดี่ยว (2) สำรวจและค้นคว้าร่วมกับกิจกรรมคิดเป็นคู่ด้วยปัญญาประดิษฐ์แบบรู้สร้าง (3) อธิบายและลงข้อสรุปร่วมกับกิจกรรมคิดเป็นกลุ่มด้วยปัญญาประดิษฐ์แบบรู้สร้างและกิจกรรมแบ่งปัน (4) ขยายความรู้ร่วมกับปัญญาประดิษฐ์แบบรู้สร้าง (5) ประเมิน . 3) ผลการใช้รูปแบบการเรียนรู้โมไบล์เลิร์นนิงแบบสืบสอบโดยใช้ปัญญาประดิษฐ์แบบรู้สร้างในการจับกลุ่มร่วมคิดเพื่อส่งเสริมการคิดอย่างมีวิจารณญาณของนักเรียนมัธยมศึกษาตอนปลาย พบว่า คะแนนการคิดอย่างมีวิจารณญาณหลังเรียนสูงกว่าก่อนเรียนอย่างมีนัยสำคัญที่ระดับ .05. .

Interpreting Neural Operators: How Nonlinear Waves Propagate In Non-Reciprocal Solids, Jonathan Colen, Alexis Poncet, Denis Bartolo, Vincenzo Vitelli

Data Science Faculty Publications

We present a data-driven pipeline for model building that combines interpretable machine learning, hydrodynamic theories, and microscopic models. The goal is to uncover the underlying processes governing nonlinear dynamics experiments. We exemplify our method with data from microfluidic experiments where crystals of streaming droplets support the propagation of nonlinear waves absent in passive crystals. By combining physics-inspired neural networks, known as neural operators, with symbolic regression tools, we generate the solution, as well as the mathematical form, of a nonlinear dynamical system that accurately models the experimental data. Finally, we interpret this continuum model from fundamental physics principles. Informed by …

Deep Transfer Learning-Based Bird Species Classification Using Mel Spectrogram Images, Mrinal Kanti Baowaly, Bisnu Chandra Sarkar, Md.Abul Ala Walid, Md. Martuza Ahamad, Bikash Chandra Singh, Eduardo Silva Alvarado, Imran Ashraf, Md. Abdus Samad

School of Cybersecurity Faculty Publications

The classification of bird species is of significant importance in the field of ornithology, as it plays an important role in assessing and monitoring environmental dynamics, including habitat modifications, migratory behaviors, levels of pollution, and disease occurrences. Traditional methods of bird classification, such as visual identification, were time-intensive and required a high level of expertise. However, audio-based bird species classification is a promising approach that can be used to automate bird species identification. This study aims to establish an audio-based bird species classification system for 264 Eastern African bird species employing modified deep transfer learning. In particular, the pre-trained EfficientNet …

Effect Of Alkaline Water In Controlling Oral Ph, Duc M. Nguyen

Dental Hygiene ETDs

This study was motivated by the widespread prevalence of dental caries, acknowledged as a global concern and often deemed a pandemic, coupled with the realization of limitations in existing caries prevention methods. The surge in the popularity of alkaline water for daily use, recognized for its health benefits, prompted an exploration of its potential role in averting dental caries. The central hypothesis, focusing on the remineralization benefits of alkaline water as a preventive method for dental caries, formed the basis of investigation. Structured with two phases and five steps, the study aimed to evaluate the impact of alkaline water on …

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2024, Michael Haederle, Claire Hannon, Nicole San Roman, Jett Loe, Sara Mota, Sarah Head

Research Annual Reports

Annual research report from the University of New Mexico Health Sciences Center.

Enhancement Of Antitumor Effects Of Berberine Chloride With A Copper(Ii) Complex Against Human Triple Negative Breast Cancer: In Vitro Studies, Duaa R. Alajroush, Brittney F. Anderson, Janae A. Bruce, Christian I. Lartey, Dazonte A. Mathurin, Sean T. Washington, Tanaya S. Washington, Sidy Diawara, Sakariyau A. Waheed, Kaylin L. Thomas, Stephen J. Beebe, Alvin A. Holder

Chemistry & Biochemistry Faculty Publications

In this study, the copper(II) complex [Cu(chromoneTSC)Cl₂]•0.5H₂O•0.0625C₂H₅OH (where chromoneTSC = (E)-N-Ethyl-2-((4-oxo-4H-chromen-3-yl)methylene)-hydrazinecarbothioamide) was synthesized and characterized; then used to carry out in vitro studies in combination with berberine chloride (BBC). The ligand and complex were characterized by elemental analysis, FTIR and NMR (¹H and ¹³C) spectroscopy, and conductivity measurements. The cytotoxic effect was analyzed by using the CCK-8 viability assay in cancer MDA-MB-231 VIM RFP and non-cancer MCF-10A cell lines. The IC₅₀ values for the complex and BBC were 21.2 ± 1.6 and 48.3 ± 2.4 μM, respectively at 24 h incubation, while the IC₅₀ value of the combination treatment …

The Impact Of Iron Supplementation On The Preterm Neonatal Gut Microbiome: A Pilot Study, Matthew Van Ormer, Maranda Thompson, Melissa Thoene, Jean-Jack Riethoven, Sathish Kumar Natarajan, Corrine K. Hanson, Ann Anderson-Berry

Journal Articles: Pediatrics

OBJECTIVE: The gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurodevelopment. However, excess colonic iron exhibits potent oxidation capacity and alters the gut microbiome-potentially facilitating the proliferation of pathological bacterial strains. Breastfed preterm infants routinely receive iron supplementation starting 14 days after delivery and are highly vulnerable to morbidities associated with gastrointestinal dysbiosis. Therefore, we set out to determine if routine iron supplementation alters the preterm gut …

The Intersection Of Special Education And Family Law: Thoughts For Family Law Attorneys In Divorce And Custody Cases, Richard D. Marsico

Articles & Chapters

The Individuals with Disabilities Education Act (IDEA) requires participating states to provide a free appropriate public education (FAPE) to children with disabilities. The IDEA gives parents of children with disabilities significant rights and major responsibilities in developing and maintaining their child’s education. Getting the most out of the IDEA for their children requires parents to commit substantial time and financial resources that are difficult to provide in the best circumstances. When parents are having marital difficulties, separated, undergoing a divorce, or negotiating child custody, these difficulties can be exacerbated as parents navigate the intersection of the federal IDEA and state …

Sound Marks, Deborah R. Gerhardt, Jon J. Lee

Faculty Publications

A lion roars just before a film rolls. A doughboy giggles. A giant green man laughs a hearty, "Ho, Ho, Ho." These iconic sounds are all federally registered as trademarks. They identify specific brands and distinguish their products and services from the competition. Human brains treat sounds like these as categorization tools and cognitive shortcuts—ideal trademark symbols. But what about the sounds your favorite toys or electronic devices make? Or those made by a fictional character in the latest blockbuster?

This Article tackles these issues and others. We push back against the widely-held belief that all unconventional trademarks—product designs, colors, …

Legal Gender Recognition In Nepal And Comparative Context, Holning S. Lau, Mara Malagodi

Faculty Publications

The Supreme Court of Nepal was a groundbreaker when it ruled in Pant v. Nepal (2007) that people have the right to change their gender on identity documents based on “self-feelings” and “self-determination” rather than medical or other criteria; at the time, no other national apex court or government had so clearly prioritized self-determination for gender identity. Pant, however, centered “third gender” persons (neither male nor female), and now the Court is considering the case of a transgender woman, Ms. Kapali, who seeks to be identified as female on her documents and is challenging authorities that rejected her requests. …

Choline Chloride – Oxalic Acid Dihydrate Deep Eutectic Solvent Pretreatment Of Barley Straw For Production Of Cellulose Nanofibers, Dileswar Pradhan, Swarna Jaiswal, Brijesh K. Tiwari, Amit K. Jaiswal

Articles

This study investigates the production of cellulose nanofibers (CNF) from Barley straw using ultrasound-assisted deep eutectic solvent (US-DES) treatment for biomass fractionation and subsequent high-intensity ultrasonication (HIUS) for nano-fibrillation. Two deep eutectic solvents (DES), synthesized from choline chloride (ChCl) and oxalic acid dihydrate (OAD) at 1:1 and 2:1 M ratio, achieved solubilisation of over 80 % of lignin and hemicellulose under optimal conditions. The purification of these DES-treated materials resulted in cellulose with a purity >88 %. CNFs, characterized by a size of <100 nm, a polydispersity index under 0.5, and a zeta potential lower than −30 mV, were successfully isolated through a combination of wet grinding and HIUS treatment. SEM and XRD results showed the formation of a network of interconnected fibres with a Type I cellulose structure. This research highlights Barley straw's potential as a sustainable source of high-value CNF from agricultural waste.