Digital Commons Network^™

Apoptotic Extracellular Vesicles Carrying Mif Regulate Macrophage Recruitment And Compensatory Proliferation In Neighboring Epithelial Stem Cells During Tissue Maintenance, Safia A Essien, Ivanshi Ahuja, George T Eisenhoffer

Faculty, Staff and Student Publications

Apoptotic cells can signal to neighboring cells to stimulate proliferation and compensate for cell loss to maintain tissue homeostasis. While apoptotic cell-derived extracellular vesicles (AEVs) can transmit instructional cues to mediate communication with neighboring cells, the molecular mechanisms that induce cell division are not well understood. Here, we show that macrophage migration inhibitory factor (Mif)-containing AEVs regulate compensatory proliferation via ERK signaling in epithelial stem cells of larval zebrafish. Time-lapse imaging showed efferocytosis of AEVs from dying epithelial stem cells by healthy neighboring stem cells. Proteomic and ultrastructure analysis of purified AEVs identified Mif localization on the AEV surface. Pharmacological …

Enriched G4 Forming Repeats In The Human Genome Are Associated With Robust Well-Coordinated Transcription And Reduced Cancer Transcriptome Variation, Ruth B De-Paula, Albino Bacolla, Aleem Syed, John A Tainer

Faculty, Staff and Student Publications

Non-B DNA G-quadruplex (G4) structures with guanine (G) runs of 2 to 4 repeats can trigger opposing experimental transcriptional impacts. Here, we used bioinformatic algorithms to comprehensively assess correlations of steady-state RNA transcript levels with all putative G4 sequence (pG4) locations genome-wide in three mammalian genomes and in normal and tumor human tissues. The human pG4-containing gene set displays higher expression levels than the set without pG4, supporting and extending some prior observations. pG4 enrichment at transcription start sites (TSSs) in human, but not chimpanzee and mouse genomes, suggests possible positive selection pressure for pG4 at human TSS, potentially driving …

Molecular Profiling Of Braf-V600e-Mutant Metastatic Colorectal Cancer In The Phase 3 Beacon Crc Trial, Scott Kopetz, Danielle A Murphy, Jie Pu, Fortunato Ciardiello, Jayesh Desai, Eric Van Cutsem, Harpreet Singh Wasan, Takayuki Yoshino, Hedieh Saffari, Xiaosong Zhang, Phineas Hamilton, Tao Xie, Rona Yaeger, Josep Tabernero

Faculty, Staff and Student Publications

The BEACON CRC study demonstrated that encorafenib (Enco)+cetuximab (Cetux)±binimetinib (Bini) significantly improved overall survival (OS) versus Cetux + chemotherapy in previously treated patients with BRAF-V600E-mutant mCRC, providing the basis for the approval of the Enco+Cetux regimen in the United States and the European Union. A greater understanding of biomarkers predictive of response to Enco+Cetux±Bini treatment is of clinical relevance. In this prespecified, exploratory biomarker analysis of the BEACON CRC study, we characterize genomic and transcriptomic correlates of clinical outcomes and acquired resistance mechanisms through integrated clinical and molecular analysis, including whole-exome and -transcriptome tissue sequencing and circulating tumor DNA genomic …

Mature Microrna-Binding Protein Qki Suppresses Extracellular Microrna Let-7b Release, Kyung-Won Min, Kyoung-Min Choi, Hyejin Mun, Seungbeom Ko, Ji Won Lee, Cari A Sagum, Mark T Bedford, Young-Kook Kim, Joe R Delaney, Jung-Hyun Cho, Ted M Dawson, Valina L Dawson, Waleed Twal, Dong-Chan Kim, Clarisse H Panganiban, Hainan Lang, Xin Zhou, Seula Shin, Jian Hu, Tilman Heise, Sang-Ho Kwon, Dongsan Kim, Young Hwa Kim, Sung-Ung Kang, Kyungmin Kim, Sydney Lewis, Ahmet Eroglu, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Junyang Jung, Je-Hyun Yoon

Faculty, Staff and Student Publications

Argonaute (AGO), a component of RNA-induced silencing complexes (RISCs), is a representative RNA-binding protein (RBP) known to bind with mature microRNAs (miRNAs) and is directly involved in post-transcriptional gene silencing. However, despite the biological significance of miRNAs, the roles of other miRNA-binding proteins (miRBPs) remain unclear in the regulation of miRNA loading, dissociation from RISCs and extracellular release. In this study, we performed protein arrays to profile miRBPs and identify 118 RBPs that directly bind to miRNAs. Among those proteins, the RBP quaking (QKI) inhibits extracellular release of the mature microRNA let-7b by controlling the loading of let-7b into extracellular …

Mechanisms Of Resistance To Oncogenic Kras Inhibition In Pancreatic Cancer, Julien Dilly, Megan T Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Brendan D Parent, Connor J Hennessey, Alexander C Jordan, Micaela Morgado, Shatavisha Dasgupta, Giselle A Uribe, Annan Yang, Kevin S Kapner, Felix P Hambitzer, Li Qiang, Hanrong Feng, Jacob Geisberg, Junning Wang, Kyle E Evans, Hengyu Lyu, Aislyn Schalck, Ningping Feng, Anastasia M Lopez, Christopher A Bristow, Michael P Kim, Kimal I Rajapakshe, Vahid Bahrambeigi, Jennifer A Roth, Kavita Garg, Paola A Guerrero, Ben Z Stanger, Simona Cristea, Scott W Lowe, Timour Baslan, Eliezer M Van Allen, Joseph D Mancias, Emily Chan, Abraham Anderson, Yuliya V Katlinskaya, Alex K Shalek, David S Hong, Shubham Pant, Jill Hallin, Kenna Anderes, Peter Olson, Timothy P Heffernan, Seema Chugh, James G Christensen, Anirban Maitra, Brian M Wolpin, Srivatsan Raghavan, Jonathan A Nowak, Peter S Winter, Stephanie K Dougan, Andrew J Aguirre

Faculty, Staff and Student Publications

KRAS inhibitors demonstrate clinical efficacy in pancreatic ductal adenocarcinoma (PDAC); however, resistance is common. Among patients with KRASG12C-mutant PDAC treated with adagrasib or sotorasib, mutations in PIK3CA and KRAS, and amplifications of KRASG12C, MYC, MET, EGFR, and CDK6 emerged at acquired resistance. In PDAC cell lines and organoid models treated with the KRASG12D inhibitor MRTX1133, epithelial-to-mesenchymal transition and PI3K-AKT-mTOR signaling associate with resistance to therapy. MRTX1133 treatment of the KrasLSL-G12D/+; Trp53LSL-R172H/+; p48-Cre (KPC) mouse model yielded deep tumor regressions, but drug resistance ultimately emerged, accompanied by amplifications of Kras, Yap1, Myc, Cdk6, and Abcb1a/b, and co-evolution of drug-resistant transcriptional programs. …

Health Literacy And Perceived Control: Intermediary Factors In The Relationship Between Race And Cardiovascular Disease Risk In Incarcerated Men In The United States, Jennifer L. Miller, Misook L. Chung, Lovoria B. Williams, Alison R. Connell, Zyad T. Saleh, Abdullah S. Alhurani, Alison L. Bailey, Mary Kay Rayens, Debra K. Moser

UK CARES Faculty Publications

Background: Black race, inadequate health literacy, and poor perceived control are predictors of increased cardiovascular disease (CVD) risk. The purpose of this study was to explore the relationships among race, health literacy, perceived control, and CVD risk while controlling for known risk factors in incarcerated men. Methods: We included data from 349 incarcerated men to examine race and CVD risk (Framingham Risk Score) using a serial mediation model with health literacy and perceived control using 95% confidence intervals (CIs) from 5000 bootstrap samples. Results: Of the participants (age, 36 ± 10; education, 12 ± 2; body mass index, 28.3 ± …

Celebrating Professor Rita Mcgrath: Winner Of The Ck Prahalad Outstanding Scholar / Practitioner Award, Strategic Management Society, Us 2022: A Conversation With Howard Thomas, Rita Mcgrath, Howard Thomas

Research Collection Lee Kong Chian School Of Business

This article highlights Rita McGrath’s extraordinary career and contributions to management thinking, particularly at the intersection of strategy and innovation. Raised in a science-oriented family, McGrath’s academic journey began with a PhD at Wharton and continued at Columbia Business School. She pioneered concepts like “Discovery-Driven Planning” and the idea of “transient competitive advantage,” reshaping how organisations navigate uncertainty and innovation. Her works, including The End of Competitive Advantage and Seeing Around Corners, blend rigorous research with practical insights. A tireless advocate for diversity in academia, McGrath’s achievements bridge academic excellence and real-world impact, serving as an inspiration for future leaders.

State Of The Fisheries: Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2023/24, Stephen J. Newman, Jenny Moore, Daniel J. Gaughan

Status Reports of the Fisheries and Aquatic Resources

This edition of the “State of the fisheries” continues the tradition of annually reporting on the status of exploited fish and their habitats in Western Australia. Critically, the reports provide overviews of the science outcomes that underpin management of fishing across the state.

Scientifically assessing the status of fish resources and potential impacts on ecosystems is inherently challenging; I acknowledge and thank the dedicated fisheries science teams and various support staff for again producing outstanding, robust scientific results that are summarised herein. I similarly acknowledge (i) the fisheries management team who use the science outcomes in policy development and to …

Therapeutic Targeting Of Hypoxia Inducible Factor In Acute Respiratory Distress Syndrome, Thu T Tran, Holger K Eltzschig, Xiaoyi Yuan

Faculty, Staff and Student Publications

Acute respiratory distress syndrome (ARDS) is characterized by bilateral chest infiltration and acute hypoxic respiratory failure. ARDS carries significant morbidity and mortality despite advancements in medical management, calling for the development of novel therapeutic targets. Hypoxia-inducible factor (HIF) is a heterodimeric protein involved in various essential pathways, including metabolic reprogramming, immune modulation, angiogenesis and cell cycle regulation. HIF is routinely degraded in homeostasis conditions via the prolyl hydroxylase domain/von Hippel-Lindau protein pathway. However, HIF is stabilized in ARDS via various mechanisms (oxygen-dependent and independent) as an endogenous protective pathway and plays multifaceted roles in different cell populations. This review focuses …

Calcineurin Inhibition Enhances Caenorhabditis Elegans Lifespan By Defecation Defects-Mediated Calorie Restriction And Nuclear Hormone Signaling, Priyanka Das, Alejandro Aballay, Jogender Singh

Faculty, Staff and Student Publications

Calcineurin is a highly conserved calcium/calmodulin-dependent serine/threonine protein phosphatase with diverse functions. Inhibition of calcineurin is known to enhance the lifespan of Caenorhabditis elegans through multiple signaling pathways. Aiming to study the role of calcineurin in regulating innate immunity, we discover that calcineurin is required for the rhythmic defecation motor program (DMP) in C. elegans. Calcineurin inhibition leads to defects in the DMP, resulting in intestinal bloating, rapid colonization of the gut by bacteria, and increased susceptibility to bacterial infection. We demonstrate that intestinal bloating caused by calcineurin inhibition mimics the effects of calorie restriction, resulting in enhanced lifespan. …

The Novel Estrogen Receptor Beta Agonist Egx358 And Apoe Genotype Influence Memory, Vasomotor, And Anxiety Outcomes In An Alzheimer’S Mouse Model, M. R. Schwabe, A. W. Fleischer, R. K. Kuehn, S. Chaudhury, J. M. York, D. S. Sem, William A. Donaldson, M. J. Ladu, K. M. Frick

Chemistry Faculty Research and Publications

Introduction: Alzheimer’s disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and anxiety, and can reduce dementia risk, it is associated with increased risks of breast and uterine cancer due to estrogen receptor alpha (ERα)-mediated increases in cancer cell proliferation. Because ERβ activation reduces this cell proliferation, selective targeting of ERβ may provide a safer method of improving memory and reducing hot flashes in menopausal women, including those with AD. APOE genotype influences the response to ET, although it is …

Localized Intratumoral Delivery Of Immunomodulators For Oral Cancer And Oral Potentially Malignant Disorders, Nourhan I Hussein, Andrea H Molina, Gemalene M Sunga, Moran Amit, Yu Leo Lei, Xiao Zhao, Jeffrey D Hartgerink, Andrew G Sikora, Simon Young

Faculty, Staff and Student Publications

Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.

Association Analysis Of Mitochondrial Dna Heteroplasmic Variants: Methods And Application, Xianbang Sun, Katia Bulekova, Jian Yang, Meng Lai, Achilleas N Pitsillides, Xue Liu, Yuankai Zhang, Xiuqing Guo, Qian Yong, Laura M Raffield, Jerome I Rotter, Stephen S Rich, Goncalo Abecasis, April P Carson, Ramachandran S Vasan, Joshua C Bis, Bruce M Psaty, Eric Boerwinkle, Annette L Fitzpatrick, Claudia L Satizabal, Dan E Arking, Jun Ding, Daniel Levy, Chunyu Liu

Faculty, Staff and Student Publications

We rigorously assessed a comprehensive association testing framework for heteroplasmy, employing both simulated and real-world data. This framework employed a variant allele fraction (VAF) threshold and harnessed multiple gene-based tests for robust identification and association testing of heteroplasmy. Our simulation studies demonstrated that gene-based tests maintained an appropriate type I error rate at α = 0.001. Notably, when 5 % or more heteroplasmic variants within a target region were linked to an outcome, burden-extension tests (including the adaptive burden test, variable threshold burden test, and z-score weighting burden test) outperformed the sequence kernel association test (SKAT) and the original burden …

Surgical Predictors Of Clinical Outcome 6 Years After Revision Acl Reconstruction, Rick W Wright, Laura J Huston, Amanda K Haas, Jacquelyn S Pennings, Christina R Allen, Daniel E Cooper, Thomas M Deberardino, Warren R Dunn, Brett Brick A Lantz, Kurt P Spindler, Michael J Stuart, Annunziato Ned Amendola, Christopher C Annunziata, Robert A Arciero, Bernard R Bach, Champ L Baker, Arthur R Bartolozzi, Keith M Baumgarten, Jeffrey H Berg, Geoffrey A Bernas, Stephen F Brockmeier, Robert H Brophy, Charles A Bush-Joseph, J Brad Butler, James L Carey, James E Carpenter, Brian J Cole, Jonathan M Cooper, Charles L Cox, R Alexander Creighton, Tal S David, David C Flanigan, Robert W Frederick, Theodore J Ganley, Charles J Gatt, Steven R Gecha, James Robert Giffin, Sharon L Hame, Jo A Hannafin, Christopher D Harner, Norman Lindsay Harris, Keith S Hechtman, Elliott B Hershman, Rudolf G Hoellrich, David C Johnson, Timothy S Johnson, Morgan H Jones, Christopher C Kaeding, Ganesh V Kamath, Thomas E Klootwyk, Bruce A Levy, C Benjamin Ma, G Peter Maiers, Robert G Marx, Matthew J Matava, Gregory M Mathien, David R Mcallister, Eric C Mccarty, Robert G Mccormack, Bruce S Miller, Carl W Nissen, Daniel F O'Neill, Brett D Owens, Richard D Parker, Mark L Purnell, Arun J Ramappa, Michael A Rauh, Arthur C Rettig, Jon K Sekiya, Kevin G Shea, Orrin H Sherman, James R Slauterbeck, Matthew V Smith, Jeffrey T Spang, Steven J Svoboda, Timothy N Taft, Joachim J Tenuta, Edwin M Tingstad, Armando F Vidal, Darius G Viskontas, Richard A White, James S Williams, Michelle L Wolcott, Brian R Wolf, James J York

Faculty, Staff and Student Publications

Background: Revision anterior cruciate ligament (ACL) reconstruction has been documented to have inferior outcomes compared with primary ACL reconstruction. The reasons why remain unknown.

Purpose: To determine whether surgical factors performed at the time of revision ACL reconstruction can influence a patient's outcome at 6-year follow-up.

Study design: Cohort study; Level of evidence, 2.

Methods: Patients who underwent revision ACL reconstruction were identified and prospectively enrolled between 2006 and 2011. Data collected included baseline patient characteristics, surgical technique and pathology, and a series of validated patient-reported outcome instruments: Knee injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) …

Uterine-Conserving Treatment Options For Atypical Endometrial Hyperplasia And Early Endometrial Cancer, Naomi N Adjei, Mikayla Borthwick Bowen, Roni Nitecki Wilke, Melinda S Yates, Shannon N Westin

Faculty, Staff and Student Publications

Purpose of review: This review aims to synthesize available literature on uterine-conserving treatment options for atypical endometrial hyperplasia and grade 1 endometrial carcinoma while highlighting remaining unanswered questions.

Recent findings: The need for uterine-conserving treatment options for atypical endometrial hyperplasia and grade 1 endometrial carcinoma is growing with the increasing number of cases in younger patients or those who cannot undergo surgery. We reviewed the oncological and reproductive outcomes associated with endocrine therapies used for atypical endometrial hyperplasia and grade 1 endometrial carcinoma. The rising prevalence of delayed childbearing, obesity, and diabetes in reproductive-age individuals and of medical comorbidities associated …

Privacy Law's Incumbency Problem, Peter Ormerod

Faculty Publications

Policymakers and scholars concerned with the power of informational platforms are questioning how traditional doctrinal silos like privacy law and antitrust law interact in digital markets. Their interaction has taken on new urgency in recent years as states have enacted a flurry of consent-based privacy laws and as digital markets have become increasingly dominated by the same few firms

Contemporary debates about the interaction of competition and privacy tend to ask what role, if any, privacy should play in the antitrust analysis. Little has been written about how new privacy laws shape the competitive landscape. This Article argues that consent-based …

Ad Fontes: Divergence-Time Estimation And The Age Of Angiosperms, Stephen A. Smith, Jeremy M. Beaulieu

Biological Sciences Faculty Publications and Presentations

Accurate divergence times are essential for interpreting and understanding the context in which lineages have evolved. Over the past several decades, debates have surrounded the discrepancies between the inferred molecular ages of crown angiosperms, often estimated from the Late Jurassic into the Permian, and the fossil record, placing angiosperms in the Early Cretaceous. That crown angiosperms could have emerged as early as the Permian or even the Triassic would have major implications for the paleoecological context of the origin of one of the most consequential clades in the tree of life. Here, we argue, and demonstrate through simulations, that the …

The Divergent Responses Of Salinity Generalists To Hyposaline Stress Provide Insights Into The Colonisation Of Freshwaters By Diatoms, Kathryn J. Judy, Eveline Pinseel, Kala M. Downey, Jeffrey A. Lewis, Andrew J. Alverson

Biological Sciences Faculty Publications and Presentations

Environmental transitions, such as the salinity divide separating marine and fresh waters, shape biodiversity over both shallow and deep timescales, opening up new niches and creating opportunities for accelerated speciation and adaptive radiation. Understanding the genetics of environmental adaptation is central to understanding how organisms colonise and subsequently diversify in new habitats. We used time-resolved transcriptomics to contrast the hyposalinity stress responses of two diatoms. Skeletonema marinoi has deep marine ancestry but has recently invaded brackish waters. Cyclotella cryptica has deep freshwater ancestry and can withstand a much broader salinity range. Skeletonema marinoi is less adept at mitigating even mild …

Mouse Mammary Tumor Virus (Mmtv) Genomic Rna (Grna) Packaging: Selective Grna Encapsidation Is Facilitated By Long-Range Interactions (Lris) That Facilitate Specific Gag Binding, Suresha G. Prabhu

Dissertations

Mouse mammary tumor virus (MMTV) is a betaretrovirus that induces breast cancer and sporadically, T-cell lymphomas in mice. MMTV serves as a pertinent model for elucidating the mechanism(s) of oncogenesis and the genetics associated with the development of mammary tumors. Being a rodent retrovirus, MMTV is phylogenetically distant from human and other primate retroviruses; thus, positioning it ideally as a potential vector of choice for human gene therapy. This may circumvent safety concerns such as recombination with other related endogenous human retroviruses. In addition, MMTV is distinct from most other retroviruses, but similar to lentiviruses, in that it has the …

Perceptions Of Substance Use Among The Latino Community In Massachusetts: A Qualitative Analysis, Fabián Torres-Ardila, Mariana Beu Rae, Germán Chiriboga, Kathryn G. Bateman, Daniela Bravo, Astha Lama, Leandra Vallejo

Gastón Institute Publications

The Mauricio Gastón Institute is a part of the Collaborative of Asian American, Native American, and Latino and African American Institutes (CANALA), linking institutes at the University of Massachusetts Boston that are dedicated to serving communities of color.1 In collaboration with CANALA, the Gastón Institute took part in a project that aims to help the Massachusetts Bureau of Substance Addiction Services (BSAS) better understand how Latino, Black, and Asian American communities in Massachusetts perceive and experience the opioid crisis. The Gastón Institute’s study focused on the Latino community and aimed to answer the following questions: 1. To what extent, and …

Yeast Diversity In Honey Produced By Wild Honeybees At Different Elevations, Medhina Magdalena, Candra Rahmani Priyambada, Donny Widianto, Sri Wedhastri, Irfan Dwidya Prijambada

Baghdad Science Journal

Yeasts inhabit diverse natural environments, including the honeycombs of wild honeybee colonies residing at different elevations. This study investigates yeast populations in honeycombs located at two sampling sites, Bligo and Sukomulyo, Central Java Province, Indonesia, situated in a montane region at elevations of 131.1 and 676 meters above sea level, respectively. Out of the 40 yeast isolates collected, 12 distinct fingerprints were identified, representing ten strains across four species. Debaryomyces hansenii emerged as the predominant species, accounting for seven of the total strains, and being found at both sampling sites. The remaining species included Priceomyces melissophilus, Cystobasidium minutum, and Meyerozyma …

Conceptions Of Latinos And Latinas About The Grieving Process And Associate Concepts Of Dying, Death, Bereavement, And Loss: A Covid-19-Post-Pandemic Case Study, Rosario Garcia Ortiz

Dissertations

The purpose of this study was to recognize the grieving process and the related concepts of Latinos who lost a loved one to the COVID-19 pandemic. Death and dying have been studied in the United States, with limited studies focusing on the Latino culture. The COVID-19 pandemic was a devastating experience for the world and continues to be studied for understanding and lessons in the aftermath. This research included four participants from the Latino culture who lost a loved one during the COVID-19 pandemic. An inductive approach and data analysis were used to form theoretical constructs. Three main categories were …

Utilization Of Localized Surface Plasmon Resonance Of Silver Nanoparticles For ‎The Spectrophotometric Estimation Of Amlodipine And Hydrochlorothiazide, Rasul Jameel Ali, Lazeeza Sattar Omer, Nagham Nadhim Habeeb, Asmaa Ghanim Dawood

Baghdad Science Journal

A potent long-acting calcium channel blockers is amlodipine. Patient with high blood pressure can take it to treat high blood pressure, angina pectoris, and reduce the risk of stroke. Hydrochlorothiazide, a diuretic, is used to treat edema and hypertension. Additionally, it is used to treat certain types of diabetes, hyperglycemia and hypokalemia. These drugs are widely available in the market and are commonly used orally. Therefore, a rapid, accurate, and inexpensive method for the determination of amlodipine and hydrochlorothiazide was developed and validated. This method is based on the ability of these drugs to reduce Ag +1 to Ag 0 …

Effect Of Graphene And Fe3o4 On The Protection Efficiency Of Polyeugenol Conducted Coating For Stainless Steel 316l In Nacl Solution, Ayat Monther Alqudsi, Khulood Abid Saleh

Baghdad Science Journal

Corrosion is the term for the surface disintegration of metals and alloys in a specific environment. Corrosion processes change a metal alloy's chemical properties as well as its mechanical behaviors. To stop rusting, a novel strategy based on an original material has been applied. By electrochemically synthesizing polyEugenol(PE)/nanocomposite (Grapgene,Fe3O4) on stainless steel 316L (SS316L), which serves as the working electrode, using the electropolymerization approach, conducting polymer-composites are material types that show promise for anticorrosion. The atomic force microscopy images (AFM) and Fourier transform-infrared spectroscopy analyses were used to evaluate the produced coated polymer. The results showed that, in comparison to …

Eeg Eye Blink Artifacts Removal With Wavelet Denoising And Bandpass Filtering, Ebtesam N. Alshemmary, Bushra K. Hilal, Azmi Sh. Abdulbaqi, Mohammed A. Ahmed, Zhentai Lu

Baghdad Science Journal

Many data sources can be analyzed using Wavelet Transforms (WT), a mathematical technique frequently used for extracting information from them. Although WT was effective at Blind Source Separation (BSS), it had some limitations, such as signal loss. The problem has been addressed with the introduction of a joint algorithm that combines WT with Frequency Domain Filtering (BPF). Wavelet Denoising Technique (WDT) and Band-Pass Filtering (BPF) are employed in this research to propose an innovative algorithm for combining advanced wavelet transform methods. Combining these two techniques helps reduce eye flutter in electroencephalograms (EEGs).FP1 signals produced by eye movement are filtered out …

The Role Of Gut Hormonal Aspect In Iraqi Patients Subjected To Sleeve Gastrectomy, Rafida M. Al-Amiri, Hanaa S. Kadhum, Falih M. Ali

Baghdad Science Journal

There are a variety of obesity surgeries and procedures in which obese individuals undergo. Primarily, they alter satiety and hunger hormone levels in the gut. Moreover, standard method of such procedures can result in long-term weight loss. Ghrelin (Ghr) is a gut hormone that regulates food intake. Laparoscopic Sleeve gastrectomy (LSG) is one method for treating morbid obesity (MO), which could modulate its secretion. The aim of the present study was to demonstrate the effect of sleeve gastrectomy on gut hormones. This study was conducted at Al-Basrah metabolic and Bariatric Surgery Center, Iraq, from December 2021 to March 2022, on …

Synthesis And Identification Of Triorganotin (Iv)-Tyrosine Complexes And Study Their Applications As Antioxidant By Dpph And Cuprac Methods., Rafid Ryyis Arraq, Angham G. Hadi

Baghdad Science Journal

Abstract Through condensation reactions between tyrosine (ligand) and triorganotin (IV) chloride salts in the presence of sodium hydroxide, three triorganotin (IV)-tyrosine complexes were successfully synthesized. All the components were dissolved in methanol and refluxed for five hours. The produced complexes were characterized by elemental analysis (CHN), Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy (1H, 13C and 119Sn-NMR). Based on spectrum measurements, trigonal bipyramidal geometries for the complexes produced in yields of 85–97% were assigned. Using the DPPH and CUPRAC methods, this study examined the antioxidant activity of tri organotin (IV)-tyrosine complexes. Due to the metal moiety, organotin (IV) …

Deep Learning Based Models For Drug-Target Interactions, Ali K. Abdul Raheem, Ban N. Dhannoon

Baghdad Science Journal

The typical drug development approach is slow, costly, and fraught with failure - scientists examine millions of compounds, but only a few make it to preclinical or clinical testing. Machine learning (ML), a subset of AI, is a fast-expanding subject many pharmaceutical businesses increasingly utilize. Incorporating machine learning technologies into the drug development process can aid in automating repetitive data processing and analysis processes. ML techniques may be used at several stages of drug development, including drug property prediction, drug-target interaction (DTI) prediction, and De Novo drug design. DTIs are a critical component of the drug development process. When a …

Phytochemical Analysis Of The Ethanol Extract Of Binahong (Anredera Cordifolia (Ten.) Steenis) Leaves By Uv-Vis Spectroscopy, Rusdiana Rusdiana, Tri Widyawati, Dina Keumala Sari, Sry Suryani Widjaja

Baghdad Science Journal

Binahong (Anredera cordifolia) leaves contain chemical compounds that can be used to promote anti-obesity. This study aimed to examine the phytochemical and anti-obesity properties of the ethanol extract of binahong leaves. The binahong extract was obtained by maceration of the leaves, followed by ethanol extraction. Phytochemical analysis was performed by UV-Vis spectroscopy to identify and determine the levels of flavonoids, phenolic compounds, alkaloids, and tannins in the extract, using quercetin as a standard for calibration. Absorbance was measured at a wavelength of 430 nm. The flavonoid, glycoside, tannin, saponin, and steroid/terpenoid contents were determined, but alkaloid compounds were not found. …

Synthesis Catalyst Of Loading Nano Platinum On Graphene Nanosheets And Photodegradation Of Bromophenol Blue In Ultra-Violet Light., Sanaa Tareq, Souad A Mousa, Eman A Muhammed

Baghdad Science Journal

Nano Platinum was used as a new photocatalyst, which was loaded onto graphene for an effective photocatalyst under UV light used in dye photodegradation applications of dye as a common pollutant for water. Thus, platinum loaded on graphene (Pt/ GNS) catalyst was prepared by the sol immobilization method. The morphology of the synthetic photocatalyst has been characterized and investigated using a High-resolution Transmission electron microscope (HRTEM) and Energy Dispersive X-ray spectroscopy (EDX) attached to FESEM. By measuring the adsorption/adsorption N2 using a Micrometrics surface analyzer, the Brunauer−Emmett−Teller (BET) surface areas of the photocatalysts were determined. The photocatalyst's crystalline structure was …