Digital Commons Network^™

D-Methionine Improves Spatial Navigation And Attenuates Oxidative Stress And Amyloid Pathology In A Sex-Specific Manner., Mackenzie R Peck, Jenelle E Chapman, Tiarra Hill, Kathleen Quinn, Erol D Ikiz, Angel Lopez, Erin R Hascup, Chilman Bae, Kevin N Hascup

Articles

Background

Oxidative stress and maladaptive neuroimmune activation contribute to cognitive decline in Alzheimer's disease (AD) and represent therapeutic targets beyond amyloid-centered approaches.

Objective

To determine whether oral D-methionine (D-Met), a redox-active amino acid, reduces amyloid pathology and lipid peroxidation and confers disease-modifying benefits in AD models.

Methods

Male and female APP/PS1 and APP^NL−Fmice with advanced AD pathology received oral D-Met or vehicle. Behavioral assessments included locomotor activity and hippocampal-dependent spatial learning and memory. Amyloid burden, lipid peroxidation, peripheral metabolic, and inflammatory markers, and hippocampal microglial phenotypes were evaluated.

Results

D-Met did not alter locomotor or exploratory behavior but …

The Role Of Mitochondrial And Lysosomal Damage In Neurotoxicity From Parkinson 'S-Related Environmental Exposures, Neda Ilieva

ETDs from 2020-2029

Parkinson's disease (PD) is a progressive motor neurodegenerative disorder with a predominantly idiopathic etiology. More recently, however, the contribution of exogenous risk factors such as environmental contaminants has become of interest. Some endogenous genetic risk factors have been well characterized, but the mechanisms by which exogenous insults, such as environmental contaminants, drive dopaminergic neurodegeneration remain incompletely understood. This dissertation will address how environmental contaminants converge on mitochondrial and lysosomal dysfunction to activate parallel neurotoxic signaling pathways, with a focus on the LRRK2 kinase and the cGAS-STING innate immune pathway. Chapter 2 demonstrates that pharmacological inhibition of LRRK2 kinase activity protects …

Hla Allele And Haplotype Diversity In Central Anatolia: A Comparative Analysis Of Donors And Transplant Candidates Across Six Hla Loci (Hla-A, Hla-B, Hla-C, Hla-Drb1, Hla-Dqb1, And Hla-Dpb1), Emel Yantir, Eren Gündüz, Ertuğrul Çolak

Turkish Journal of Medical Sciences

Background/aim: Human leukocyte antigen (HLA) polymorphisms play a central role in immune recognition, disease susceptibility, and transplant success. The distribution of HLA alleles and haplotypes varies among ethnic and geographic populations. Despite several regional studies conducted in Türkiye, large-scale and comprehensive investigations comparing HLA profiles between healthy individuals and transplant candidates remain limited. The aim of this study was to compare the distribution of HLA profiles among donors, hematopoietic stem cell transplantation (HSCT) candidates, and solid organ transplant candidates.

Materials and methods: A total of 8472 individuals were included in the study, comprising 6422 donors and 2050 transplant candidates. HLA …

Impact Of Race-Based And Race-Free Ckd-Epi Equations On Estimated Glomerular Filtration Rate In A Multicenter Retrospective Cohort Of Autosomal Dominant Polycystic Kidney Disease, Özgür Akin Oto, Abdulmeci̇t Yildiz, İsmai̇l Koçyi̇ği̇t, Hali̇l Yazici, Sai̇de Eli̇f Güllülü Boz, Yi̇ği̇t Kurtuluş, Alparslan Demi̇ray, Müge Doksan, Vafa Suleymanova, Ece Ük, Alper Akin, Bahar Bastani, John C. Edwards, Krista Leigh Lentine, Yaşar Kerem Çalişkan

Turkish Journal of Medical Sciences

Background/aim: The 2021 revision of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, which eliminates race-based coefficients, may significantly influence disease staging and treatment in autosomal dominant polycystic kidney disease (ADPKD). This study was designed to evaluate the impact of the 2021 race-free CKD-EPI equation on estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) staging in a multi-ethnic ADPKD population.

Materials and methods: In this multicenter, retrospective cohort study, 597 ADPKD patients were evaluated, including 515 self-identified as Caucasian and 82 as African-American. eGFR values at baseline and final follow-up were calculated using both the 2009 and 2021 …

Association Of Vitamin D, Oxidative Stress Markers, And Hormonal Factors With Male Infertility: A Case-Control Study In Pakistan, Muhammad Tayyab Ihsan, Ayesha Ali Malick, Sher Khan, Sher Khan, Muhammad Tahir Khan, Haq Nawaz Khan, Rehana Rehman

Turkish Journal of Medical Sciences

Background/aim: Infertility impacts around 15% of couples worldwide, with male factors accounting for approximately 50% of cases. Despite this significant share, male infertility remains understudied, particularly in developing nations such as Pakistan. The present study explores the association between male infertility and seminal plasma concentrations of oxidative stress markers, inhibin B, and vitamin D, along with their relationship with sperm parameters.

Materials and methods: The dataset of the study consisted of seminal plasma levels from 30 fertile and 60 infertile males. Total antioxidant capacity (TAC), Vitamin D, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), lipid peroxide (LPO), superoxide dismutase (SOD), and inhibin B …

Preliminary Population Genetic Analysis Of 12 X-Str Loci In A Sample From Türkiye: Allele Frequencies, Haplotype Diversity, And Linkage Disequilibrium​, Hizir Asliyüksek, Esra Güzel Tanoğlu, Abdulkadi̇r Can, Muhammed Fevzi̇ Esen, Yusuf Atan

Turkish Journal of Medical Sciences

Background/aim: X-chromosomal short tandem repeats (X-STRs) are informative genetic markers in kinship testing and specific forensic contexts, particularly when standard autosomal approaches are less informative. This study aimed to provide preliminary allele frequency, haplotype diversity, and linkage disequilibrium (LD) data for 12 X-STR loci in a sample from Türkiye.

Materials and methods: A total of 136 unrelated individuals from Türkiye were genotyped for 12 X-STR loci. Inferential analyses of X-linked loci require diploid genotypes; therefore, allele frequencies, Hardy–Weinberg equilibrium (HWE), LD, and regional comparisons were based primarily on female samples (n = 115), whereas male haplotypes (n = 21) were …

In Silico Evaluation Of The Role Of Pea3 Subfamily Ets Transcription Factors In Chemoresistance In Ovarian Cancer, Fevzi̇ Coşkun Sökmen, Lai̇ka Kardana, Hi̇kmet Yilmaz, Ahmet Çağlar Özketen, Aynur Karadağ Gürel, Özge Atay, Hasan Hüseyi̇n Kazan

Turkish Journal of Medical Sciences

Background/aim: The E26 transformation-specific family of transcription factors regulates the cell cycle and apoptosis that are crucial for carcinogenesis. More specifically, the PEA3 subfamily—comprising ETS variant (ETV) transcription factors ETV1, ETV4, and ETV5—has been implicated in multiple oncogenic signaling pathways and chemotherapy resistance. While cisplatin is still a widely used chemotherapeutic treatment for ovarian cancer, its therapeutic efficacy is sometimes limited by the induction of resistance mechanisms. The present study investigates the potential role of PEA3 subfamily genes in cisplatin resistance in ovarian cancer through comprehensive in silico analyses.

Materials and methods: Cisplatin response data for ovarian cancer were obtained …

Omega-3–Rich Fish Oil Lipid Emulsions Significantly Prevent Sepsis-Driven Mesenteric Hypoperfusion And Multi-Organ Injury In Murine Models, Gökşen Öz, Esi̇n Özçelebi̇, Ayşe Yeşi̇m Göçmen, Cenk Sükmensüer, Selma Yildirim, Arzu Topeli̇, Alper Bektaş İski̇t

Turkish Journal of Medical Sciences

Background/aim: Parenteral feeding is used in critically ill patients when enteral nutrition is inadequate or intolerable, and the gastrointestinal tract is not functioning properly. Lipid emulsions play a major role in parenteral nutrition because they supply necessary fatty acids and a high-calorie density. We investigated the effects of parenteral lipid emulsions on mesenteric perfusion, inflammation-induced oxidation, and organ damage in lipopolysaccharide-induced mice endotoxemia model.

Materials and methods: In septic mice, organ damage induced by lipopolysaccharide was assessed by histopathology and biochemical examination. Additionally, an ultrasonic blood flowmeter was used to measure the impact of lipid emulsions on mesenteric blood flow. …

Trophic Transfer Of Fluorescent Polyethylene Microplastics In A Simplified Artemia–Oreochromis Aquatic Food Chain, Dativa J. Shilla

Tanzania Journal of Science

Microplastics (MPs) are pervasive contaminants in aquatic ecosystems, yet experimental evidence of their trophic transfer within tropical African food webs remains scarce. This study provides experimental evidence of indirect trophic transfer of microplastics from Artemia salina to Oreochromis urolepis, a cichlid species of ecological and economic importance in African inland and coastal waters. A simplified two-level food chain was established by exposing A. salina nauplii to fluorescent polyethylene microplastics (10–20 µm; 1, 10, and 100 mg L⁻¹) and subsequently feeding them to juvenile O. urolepis under controlled laboratory conditions. These concentrations were selected to represent a range of exposure levels …

The Helminthic Status Of Selected Tanzanian Subterranean Rodents, The Root-Rats (Spalacidae: Tachyoryctes Splendens) And Emini Silvery Mole-Rats (Bathyergidae: Heliophobius Argenteocinereus Emini), Jestina V. Katandukila

Tanzania Journal of Science

Root-rats (Tachyoryctes splendens) and emini silvery mole-rats (Heliophobius argenteocinereus emini) are common subterranean rodents that are essential component of the ecosystem. They serve as prey for small to medium-sized carnivores and birds of prey but their role as hosts to parasites is limited. The present study, explored the Gastrointestinal Tract (GIT) contents of 40 rodents (20 T. splendens and 20 H. a. emini, respectively) to acquire information on parasites diversity of these mammals. The GIT contents from subterranean rodents in a sex ratio of 1:1 were examined under a compound microscope to isolate helminths. The isolated helminths belonged to the …

Applying Theory Of Planned Behavior To Examine Adolescent Female Athletes’ Intentions Of Continued Sport Participation, Chris Hopkins, Casey S. Hopkins

Open Access Fund Publications

Introduction: Adolescent females discontinue sports at higher rates than males, which contributes to their lower overall physical activity during this important period of development. Potentially useful for understanding this disparity, the Theory of Planned Behavior (TPB) provides a framework to study one's intentions through their attitudes, subjective norms, and perceived behavioral control. This study examined whether TPB constructs predict female adolescents’ intentions to continue participating in sports and remain physically active.

Methods: This cross-sectional study used an online questionnaire to collect data from 271 female adolescents who recently participated in organized sports. Structural equation modeling was used to test TPB's …

Engagement With Tailored Physical Activity Interventions Among Women In Midlife With Elevated Risk For Cardiovascular Disease, Kiri Baga

Theses and Dissertations

Women in midlife (ages 40-65) with risk factors for cardiovascular disease (CVD) need physical activity (PA) interventions that are informed by and address their daily challenges and life circumstances, to reduce their chances of premature mortality from CVD. Sustaining engagement with PA interventions remains a substantial challenge for women in midlife. The aims of the proposed study were to describe participants’ PA-relevant characteristics and intervention preferences and to identify their patterns of engagement with different PA support tools (tailored PA website, intervention involving pairing women as PA partners). With respect to engagement, there was limited between-person stability in engagement outcomes …

Bridging The Gap Towards Sustainable Development: A Systematic Literature Review On Orang Asli Communities In Peninsular Malaysia, Nurfatiha Akmal Fawwazah Abdullah-Fauzi, Nursyuhada Othman, Hidayah Haris, Nur Hartini Sariyati, Farah Farhana Ramli, Kaviarasu Munian, Mohd Faudzir Najmuddin, Mohd Tajuddin Abdullah, Muhammad Abu Bakar Abdul-Latiff

Forest and Society

Orang Asli communities in Peninsular Malaysia have a complex history marked by challenges related to land rights, environmental degradation, and cultural preservation. Despite ongoing efforts to address these challenges, significant obstacles persist, particularly in healthcare access and outcomes, education, language preservation, dietary practices, religious beliefs, and policy frameworks. This systematic literature review aims to provide a comprehensive analysis of past and current research on various aspects of Orang Asli communities in Peninsular Malaysia. The primary goal is to uncover the trends of challenges and unique characteristics of the Orang Asli communities while offering valuable recommendations for improvement. The Preferred Reporting …

Extraction Of High-Quality Cashew Nutshell Liquid Using Carbon Dioxide-Expanded Hexane, Frank N. Jacob, Neema Msuya, Joseph Y.N Philip, Kando Khalifa Janga

Tanzania Journal of Science

Cashew nutshell liquid (CNSL) is a by–product from cashew processing industries containing four naturally occurring phenolic compounds. This study investigated an extraction approach using CO2–expanded hexane. The central composite design (CCD) was employed in experimental design to investigate the effects and interaction of CO 2 mole fractions and extraction temperature on the CNSL yield and quality (Colour) from Steamed CNSL. The dissolution power of the CO2–expanded hexane was assessed by determining the solubility of CNSL during the initial stages of extraction at different extraction conditions. Findings indicated that higher CO2 mole fractions reduced CNSL solubility, while higher temperatures enhanced it. …

Development And Standardization Of Teds Actuator Templates Under Ieee 1451 Framework, Jim Kang

Theses and Dissertations

The IEEE 1451 standard is a family of standards that defines a framework for smart transducers, including both sensors and actuators, to support consistent, interoperable, and cost-effective integration across diverse applications. However, the current IEEE 1451.4 standard templates only define the method for encoding Transducer Electronic Data Sheet (TEDS) information for a broad range of sensor types and applications; they do not address actuator TEDS. Specific types of sensors and actuators are being developed to assess underground environmental conditions in cold regions with widespread permafrost. Evaluating subsurface conditions before construction can help prevent high construction expenses for structures built on …

Topological Tools For The Analysis Of Complex Networks And Higher-Order Networks, Jason P. Laruez

Theses

This dissertation investigates the intersection of topological data analysis and network science, applying and extending persistent homology, Betti numbers, and simpliciality measures to study temporal, evolving, and coevolving networked systems. We introduce a multi-layer zigzag persistent homology framework for analyzing temporal hypergraphs across multiple timescales simultaneously, and validate it on the DARPA Operationally Transparent Cyber dataset, where it produces topological signatures that distinguish malicious from benign network activity by source IP. We then apply topological tools to classical generative network models and their hypergraph extensions, characterizing how Betti numbers, filling efficiencies, and simpliciality measures evolve as these models grow or …

Pinnlab: An Interactive Dashboard For Teaching Data-Driven Parameter Estimation In Differential Equations Using Physics-Informed Neural Networks, Mohan J. Parthasarathy, Padmanabhan Seshaiyer

CODEE Journal

Undergraduate instruction in ordinary differential equations (ODEs) is typically organized around the forward problem: finding solution trajectories when the governing equation and its parameters are known. In scientific practice, however, inverse problems are often more relevant, requiring unknown parameters to be inferred from noisy observations while assessing whether a proposed model is consistent with the data. We introduce PINNLab, an open-source MATLAB dashboard designed to help undergraduate students explore inverse modeling through physics-informed neural networks (PINNs). PINNLab presents PINNs as a complementary data-driven framework that connects differential equations, optimization, empirical data, and scientific machine learning. The instructional sequence is organized …

Learning To See Lesions, Not Skin Tone: Counterfactual Multimodal Learning For Fair, Trustworthy, And Text-Free Dermatology Ai, Shivam Jangid

Master’s Dissertations

Recent advances in deep learning have significantly improved the performance of automated skin lesion classification systems, enabling accurate detection of various dermatological conditions from medical images. Despite these achievements, concerns regarding fairness and generalization remain a major challenge for the deployment of such systems in real-world clinical settings. A key factor contributing to these challenges is the presence of bias in training datasets, particularly with respect to skin-tone representation. Most publicly available skin lesion datasets contain a disproportionate number of samples from individuals with lighter skin tones. As a result, deep learning models trained on these datasets often learn representations …

Deep Reinforcement Learning With Directed Asymmetry And Kolmogorov-Arnold Networks For Dismantling Interdependent Multiplex Networks, Soumyajit Dev

Master’s Dissertations

Identifying the minimum-cost node-removal sequence that fragments a complex network - the network dismantling problem is NP-hard and central to infrastructure resilience. In interdependent multiplex networks, this difficulty is compounded by cascading cross-layer failures. While deep reinforcement learning (DRL) agents utilizing graph neural network (GNN) encoders achieve near-optimal dismantling, current state-of-the-art architectures suffer from two critical limitations. Topologically, existing agents strictly assume undirected edges, rendering them inapplicable to directed systems - such as supply chains or gene regulatory cascades - where failure propagation is fundamentally asymmetric. To resolve this, we propose Disassembling Directed Interdependent Networks (DDIN). DDIN introduces an asymmetric …

Antioxidant Potential Of A Non-Heme Iron Complex: Mitigating H2O2-Induced Cellular Damage, Magy A. Mekhail, David M. Freire, Cameron Bowers, Grant Elam, Nora Del Bosque, Hannah K. Pyle, Sarah K. Dunn, Spencer Lanyon, Timothy J. Hubin, Giridhar Akkaraju, Kayla N. Green

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Iron complexes with antioxidant activity have garnered significant interest for both general and medical applications, yet few studies have yielded functional nonheme iron-based mimics for H₂O₂ mitigation in aqueous environments. Here, we investigate water-soluble nonheme iron complexes derived from 12-membered pyridinophanes (^CF₃PyN₃, PyN₃, ^NMe₂PyN₃, and Py₂N₂) to evaluate the impact of ligand scaffolds on H₂O₂ decomposition activity both in vitro and in a cellular model. Speciation and kinetic analyses reveal that both electronic and geometric modulation of the macrocyclic …

Analytical Eigenmode Framework For Triplet-Mediated Fluorescence Dynamics Under Pulsed Excitation, Bariş Demi̇rbay

Turkish Journal of Physics

An exact analytical solution to a three-state photophysical model is presented to explicitly map the time-resolved fluorescence dynamics of a fluorophore under pulsed excitation. As distinct from earlier analytical treatments that primarily focused on transient absorption and total ground-state depletion, the proposed eigenvalue-eigenvector framework captures both transient and steady-state emission responses. The photophysical model accounts for electronic transitions between the singlet ground state, the excited singlet state and a long-lived triplet state, enabling a treatment of excitation, radiative decay, intersystem crossing, together with triplet-state relaxation. By diagonalizing the rate matrix consisting of phenomenological transition rates, closed-form expressions for the time-dependent …

Comprehensive Geriatric Assessment Identifies Multidimensional Vulnerabilities In Older Adults With Heart Failure, Ci̇han Kiliç, Rengi̇n Demi̇r, Özlem Yilmaz Aykent, Zerri̇n Yi̇ği̇t, Pinar Küçükdağli, Banu Özulu Türkmen, Güli̇stan Bahat, Mehmet Aki̇f Karan

Turkish Journal of Medical Sciences

Background/aim: Heart failure (HF) in older adults is frequently accompanied by geriatric syndromes that remain unrecognized in conventional cardiac evaluations. The vulnerabilities of older adults with and without HF in terms of muscle strength, physical performance, functional capacity, frailty, nutritional status, cognition, mood, anxiety, polypharmacy, and comorbidity were investigated using comprehensive geriatric assessment (CGA).

Materials and methods: A cross-sectional study was conducted in two academic outpatient clinics, enrolling 420 adults aged ≥60 years, including 92 (21.9%) with HF. Data included sociodemographic characteristics, anthropometric measurements, and CGA parameters: handgrip strength, the Five-Times Sit-to-Stand Test (FTSST), the Short Physical Performance Battery (SPPB), …

Clinical, Hormonal, And Treatment Outcomes In 247 Patients With Acromegaly: A Single Tertiary Center Experience, Ümran Gül, Beki̇r Uçan, Hayri̇ Bostan, Hakan Düğer, Hayri̇ Kertmen, Caner Ünlüer, Hali̇l Durantaş, Oğulcan Boz, Ceren Karaçalik Ünver, Burak Menekşe, Sema Hepşen, İlknur Öztürk Ünsal, Mustafa Özbek, Erman Çakal, Muhammed Kizilgül

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the demographic, clinical, and hormonal characteristics; comorbidities; surgical pathology; treatment modalities; and long-term clinical outcomes of patients diagnosed with and managed for acromegaly at our tertiary referral center over a 15-year period.

Materials and methods: Between 2010 and 2024, 247 patients with acromegaly were evaluated. Diagnosis and biochemical remission were determined according to the 2024 Acromegaly Consensus Criteria.

Results: The median follow-up duration was 8 years (IQR: 3–14). At the time of diagnosis, the most frequent pituitary hormone deficiency was secondary adrenal insufficiency, present in 17.8% of patients. The most common comorbidities were hypertension …

Bridging The Methodological Gap In Multitrauma Literature: A Competency-Based Educational Framework And Clinical Appraisal Filter, Şaki̇r Hakan Aksu, Burcu Doğan, Merve Yazla

Turkish Journal of Medical Sciences

Background/aim: The statistical complexity of contemporary multitrauma literature has increased considerably in recent years, which may pose challenges for clinicians seeking to interpret high-impact research and apply evidence-based practices. Characterizing this methodological landscape and exploring education-oriented approaches may help to improve the interpretability of the literature and support informed clinical decision-making.

Materials and methods: A cross-sectional analysis was conducted on the 100 most-cited multitrauma studies published in Science Citation Index Expanded journals indexed in the Web of Science database between January 2018 and November 2025. The statistical methods used in each article were categorized into the three competency levels of …

Postoperative Normocalcemic Hyperparathyroidism: A Comprehensive Analysis Of 510 Cases, Alparslan Ertenli̇ce, İbrahi̇m Kilinç, Mustafa Oruç

Turkish Journal of Medical Sciences

Background/aim: Postoperative normocalcemic hyperparathyroidism (NC-HPT) is defined as elevated parathyroid hormone (PTH) levels despite normal calcium levels after parathyroidectomy for primary hyperparathyroidism (PHPT). This study investigates the demographic, biochemical, and histopathological factors associated with NC-HPT in a large patient cohort and presents the follow-up outcomes.

Materials and methods: The initial study sample included 571 patients who underwent surgery for PHPT between January 2018 and January 2024, 510 of whom were analyzed retrospectively after the application of the exclusion criteria. Preoperative and postoperative biochemical parameters, bone mineral density, pathological findings, and follow-up data were evaluated. NC-HPT was defined as postoperative PTH …

Alterations In Gut Microbiota Composition In Adult Patients With Familial Mediterranean Fever: A Pilot Case–Control Study, Nazi̇fe Şule Yaşar Bi̇lge, Vicente Pérez Brocal, Ti̇muçi̇n Kaşi̇foğlu, Uğur Bi̇lge, Ni̇lgün Kaşi̇foğlu, Andres Moya, Ener Çağri Di̇nleyi̇ci̇

Turkish Journal of Medical Sciences

Background/aim: Although familial Mediterranean fever (FMF) is a monogenic disease, recent evidence suggests that the gut microbiota may play a role in its pathogenesis or phenotypic expression. We conducted a pilot exploratory study to evaluate the intestinal microbiota composition in patients with FMF and compare it to that of healthy controls.

Materials and methods: In this prospective cohort study, 10 adult patients with FMF receiving colchicine and 10 age- and sex-matched healthy controls were enrolled. Fecal samples were collected and stored at –80 °C until DNA extraction. The V3–V4 region of the 16S rRNA gene was amplified and sequencing was …

Vnotes High Uterosacral Ligament Suspension Versus Laparoscopic Lateral Suspension In The Management Of Vaginal Vault Prolapse: Initial Experience In A Single Tertiary Center, Ramazan Adan, Fati̇h Şahi̇n, Ulya Üskent, Mehmet Gökhan Çulha, Arzu Bi̇lge Teki̇n

Turkish Journal of Medical Sciences

Background/aim: The optimal technique for vaginal vault prolapse correction has yet to be identified. This study aimed to evaluate the anatomic and functional outcomes of women who underwent vaginal natural orifice transluminal endoscopic high uterosacral ligament suspension (vNOTES HUSLS) or laparoscopic lateral suspension (LLS).

Materials and methods: This retrospective study included symptomatic women with stage ≥2 vault prolapse who underwent vNOTES HUSLS or LLS between January 2019 and June 2022 at a tertiary center. The surgical efficacy, postoperative outcomes, complication rates, and recurrence frequencies of these procedures were compared. The primary outcomes of the study included anatomical success, patient-reported (subjective) …

Innovation Hubs In Mountain West Cities, 2025, Cason Noll, Sean Curry, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet presents data on 20 innovation-dense Mountain West cities across Arizona, Colorado, Nevada, New Mexico, and Utah. The CommercialCafe report, “Santa Clara, Berkeley & Tempe Lead Among Western Innovation Hubs,”  uses 15 indicators to rank 63 western cities for innovation hub activity across three categories: employment and talent, education, and business activity.

A Caveat Regarding The Unfolding Argument: Implications Of Plasticity, Viknas N. O'Reilly-Shah, Alessandro Maria Selvitella, Aaron Schurger

Psychology Faculty Articles and Research

The unfolding argument in the neuroscience of consciousness posits that causal structure cannot account for consciousness because any recurrent neural network (RNN) can be “unfolded” into a functionally equivalent feedforward neural network (FNN) with identical input–output behavior. Subsequent debate has focused on dynamical properties and philosophy of science critiques. We examine a boundary condition on the unfolding argument for RNN systems with rapid plasticity in their connection weights. We demonstrate through rigorous mathematical proofs that rapid plasticity negates the functional equivalence between the RNN and the FNN. Our proofs address history-dependent plasticity, dynamical systems analysis, information-theoretic considerations, perturbational stability, complexity …

Hp1bp3 Loss Links Chromatin Reorganization To Metabolic Vulnerability In Glioma, Brittney Lozzi, Taylor A Gatesman, Pushan Dasgupta, Debosmita Sardar, Yeunjung Ko, Chenyu Mao, Hsiao-Chi Chen, Rachel N Curry, Dongjoo Choi, Carrie A Mohila, Melissa L Bondy, Ganesh Rao, Marco Gallo, Sameer Agnihotri, Benjamin Deneen

Duncan NRI Faculty and Staff Publications

High-grade gliomas (HGGs) are aggressive brain tumors with poor prognosis, driven in part by metabolic and epigenetic adaptations. Methionine metabolism supports HGG growth by supplying S-adenosylmethionine for methylation reactions, yet how nutrient availability influences chromatin organization in HGG remains incompletely understood. Using an immunocompetent mouse model of HGG, we found that dietary methionine restriction reduced tumor proliferation, extended survival, and induced partial nuclear inversion. We identified Hp1bp3 as a key regulator of tumor growth that functions by interacting with nuclear tethering proteins to mediate chromatin reorganization. Loss of Hp1bp3 results in the upregulation of histone demethylases leading to selective depletion …