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Preliminary Report Of The Hasp 2023 Field Season: Coring And Excavations At Efri-Ás, Laufskálaholt, Brekkukot, Grafarkot, Kálfsstaðir, Kjarvalsstaðir, Nautabú, Ingveldarstaðir, Skúfsstaðir, Garðakot, Hringver, Hólakot, And Viðvík In Hjaltadalur With Additional Geophysics At Skúfsstaðir, Guðný Zoëga, John M. Steinberg, Chiara M. Torrini, Trace J. Podder

Andrew Fiske Memorial Center for Archaeological Research Publications

This report outlines the 2023 work, including Geophysical survey, Coring, and Excavations at Efri-Ás, Laufskálaholt (on the Efri-Ás land of the Ásholt summer house), Brekkukot, Kálfsstaðir, Kjarvalsstaðir, Nautabú, Ingveldarstaðir, Skúfsstaðir, Garðakot (part of Víðines) Grafarkot (part of Víðines), Hringver, Hólakot (part of Viðvík), and Viðvík) in Hjaltadal as part of the Hjaltadalur Archaeological Survey Project (HASP). This is the third year of a scheduled three-year project. The purpose of the project is to outline the settlement sequence and regional development in Hólar and around Hjaltadal and compare them with similar studies that have been carried out in Skagafjörður. The 12 …

Racial Disparities In Snap Receipt For Eligible Asian Americans In Massachusetts, Sokha Eng, Weichun Yan, Brian Beauregard, Susan R. Crandall

Center for Social Policy Publications

Despite qualifying as income eligible, many Massachusetts families do not access SNAP (Supplemental Nutrition Assistance Program) benefits. Due to the sharp increase in the cost of living, especially the cost of housing and food expenses, more families are facing food insecurity. Thus, it is critical to ensure that families in need receive SNAP benefits. While previous studies have examined racial disparities, there is a limited focus on Asian American families. Even fewer studies disaggregate data to explore disparities among Asian American ethnic subgroups. Further, few studies have addressed disparities in SNAP receipt specifically for income eligible families.

The purpose of …

Incremental Value Of Radiomics Features Of Epicardial Adipose Tissue For Detecting The Severity Of Covid-19 Infection, Ni Yao, Yanhui Tian, Daniel Gama Das Neves, Chen Zhao, Claudio Tinoco Mesquita, Wolney De Andrade Martins, Weihua Zhou, Et. Al.

Michigan Tech Publications

Introduction. Epicardial adipose tissue (EAT) is known for its pro-inflammatory properties and association with Coronavirus Disease 2019 (COVID-19) severity. However, existing detection methods for COVID-19 severity assessment often lack consideration of organs and tissues other than the lungs, which limits the accuracy and reliability of these predictive models.

Material and methods. The retrospective study included data from 515 COVID-19 patients (Cohort 1, n=415; Cohort 2, n=100) from two centers (Shanghai Public Health Center and Brazil Niteroi Hospital) between January 2020 and July 2020. Firstly, a three-stage EAT segmentation method was proposed by combining object detection and segmentation networks. Lung …

Dynamics Of Cell Membrane Lesions And Adaptive Conductance Under The Electrical Stress, Mantas Silkunas, Olga N. Pakhomova, Giedre Silkuniene, Andrei G. Pakhomov

Bioelectrics Publications

Exceeding physiological limits of the cell membrane potential compromises structural integrity, enabling the passage of normally impermeant solutes and disrupting cell function. Electropermeabilization has been studied extensively at the cellular scale, but not at the individual membrane lesion level. We employed fast total internal reflection fluorescence (TIRF) imaging of Ca(2+) entry transients to discern individual lesions in a hyperpolarized cell membrane and characterize their focality, thresholds, electrical conductance, and the lifecycle. A diffuse and momentary membrane permeabilization without a distinct pore formation was observed already at a -100 mV threshold. Polarizing down to -200 mV created focal pores with a …

Careful Communication: A Confrontation Of Cartesian Mind/Body Dualism And Western Perceptions Of Intelligence In The Dance Classroom, Sarah Lunceford

Dance (MFA) Theses

Western perceptions of intelligence in correlation with Cartesian Mind/Body Dualism can have a detrimental impact on the way students receive and are affected by information. In collegiate settings where students participate in Western concert dance technique classrooms and dance academic courses, a student’s reputation for excelling in one area or another can influence the teacher’s perception of the student’s abilities. This can cause instructors to presume a generalized understanding of what a student is capable of and encourage an unbalanced engagement with the student’s abilities within one type of classroom versus another. This work considers the author's experience within dance …

Rhythms That {Bind}: Emerging Through Dissonance, Tessa Hailu

Dance (MFA) Theses

This thesis aims to interrogate systematic approaches to organization(s) and our innate desire for control to achieve a balanced “rhythmic” flow of life to ultimately preserve a sense of security. This investigation challenges the comforts of habits, routine, and order to push up against the binding effects of these predictable cycles that remain structured for reassurance. This research also considers what happens when one doesn’t have the choice to bind themselves TO safety but are otherwise bound BY rhythms of which they have no control. Taking into account our anatomical existence, the ecological systems in which we operate, and life’s …

Practicing Vulnerability: A Black Queer Dance That Is Never-Ending Due To The Faults Of Our American Society, Paris Ngai Gray

Dance (MFA) Theses

The performative nature of concert dance requires a profound awareness and understanding of the body and the mind. Formal dance training situates an environment where the investigation of the body is crucial, often leaving the responsibility of internal inquiry to the dancer. In my experience as a Black, Queer, and Trans/Non-Binary person assigned male at birth, this investigation has been incredibly difficult. This research explores not only the sub-cultural context that influenced my resistance to emotional maturity but also the places that shaped my connection to vulnerability and how I’ve been able to access it. The performance of Black hyper-masculinity …

"Hunter-Killer" Peptoid-Peptide Conjugate To Target And Eliminate Cancer Stem Cells, Breanne F. Mcelderry

Chemistry Theses

In the contemporary paradigm concerning the emergence of therapy-resistant recurrent cancer, recent studies posit the existence of a limited population of self-renewing malignant progenitors known as cancer stem cells (CSCs). The presence of CSCs explains why tumors often relapse despite clinical remission with initial therapeutic interventions. Consequently, the development of innovative therapeutic modalities specifically tailored to target and eliminate CSCs represents a highly promising strategy for eradicating cancer without the risk of recurrence. In previous research, we successfully developed a synthetic peptoid-based ligand CL-1-19-1 that selectively binds to CSC over non-CSC. However, CL-1-19-1 did not exhibit any significant inhibitory effect …

Cancer-Associated Mdm2 W329g Mutant Attenuates Ribosomal Stress-Mediated P53 Responses To Promote Cell Survival And Glycolysis, Sally Lien, Thomas P Whitbread, Shiva O Shastri, Jamie A Contreras, Ruiying Zhao, Yan Zhu

Faculty, Staff and Student Publications

Although amplification/overexpression is the predominant mechanism for the oncogenic properties of MDM2, an increasing number of MDM2 somatic missense mutations were identified in cancer patients with the recent advances in sequencing technology. Here, we characterized an MDM2 cancer-associated mutant variant W329G identified from a patient sample that contains a wild-type p53 gene. Trp329 is one of residues that were reported to be critical to MDM2's binding to ribosomal protein L11 (RPL11). We found that the MDM2 W329G mutant was resistant to the inhibitory effect of RPL11 on MDM2-mediated p53 ubiquitination and degradation, in line with its defect on RPL11 binding. …

Champagne Wishes And A Domestic Beer Budget: Assessing And Supporting Serials Access At A Carnegie R2, Chad E. Buckley, Julie Murphy, Rachel E. Scott, Cassie Thayer-Styes, Anne Shelley

Faculty and Staff Publications – Milner Library

As library budgets are cut or remain flat, librarians asked to do more with less are considering diverse data to investigate how best to invest limited funds. The data available to librarians are extensive but they may also be contradictory. In this presentation, we contextualize findings from interviews conducted with Illinois State University faculty with institutional and collections data. Using the words of faculty members across disciplines, we highlight some of the tensions around discovery and access to scholarly literature, perceptions of urgency, and engagement with open access. The interview results--triangulated with institutional usage and cost data—suggest a variety of …

Brief Of Amici Curiae Scholars For The Advancement Of Children’S Constitutional Rights In Support Of Defendants-Appellees: Constitutional Rights In Support Of Defendants-Appellees: St. Mary Catholic Parish V. Roy, Lauren Fontana, Tanya M. Washington, Catherine Smith, Robin Walker Sterling, Suzette Malveaux, Jeremiah Chin, Sara S. Hildebrand

Faculty Publications By Year

No abstract provided.

Investigation Of The Relationships Between Hydraulic, Physical, And Biological Soil Parameters At A Vineyard In Saint James, Missouri, Lyndsey Bennett

Masters Theses

"Soil is a living, dynamic system that performs vital functions such as crop production, organic matter decomposition, and the flow and transport of water. Given the pressures of food and in some locales water security, climate change, and sustainability, farmers, scientists, and other related specialists and stakeholders must have access to understandable soil health indicators as well as the soil hydraulic function parameters to maximize crop growth while maintaining soil health. Although biological and physical soil parameters are different, we aim to evaluate their relationship at the field scale. Hydraulic conductivity in the vadose zone may be especially important, as …

Development Of A Novel Bioink For Human Vascularized Organoids, Bradley Allen Bromet

Masters Theses

"There is a need for a model to better mimic human physiology in the clinic, so the objective was to develop a novel bioink for a 3D tissue model to study human disease and development in a dynamic 3D environment. The results from each corresponding study helped in developing a novel bioink for use in a bio printed human vascularized organoid. The bioink composed of alginate with other natural hydrogels to function as extracellular matrix and with the addition of borophosphate bioactive glasses (BPBGs) to replace growth factors, can be used with multiple cell types to bio print the proposed …

Environmental Health And Impact Of Workload On Errors For Wildland Fire Personnel, Michael Bryan Held

Masters Theses

"This thesis offers an analysis of how environmental health and workload affect wildland fire dispatchers and firefighters, combining results from two studies. The first study, "Environmental Health of Wildland Firefighters: A Scoping Review," performs a scoping review of scientific literature that examines the unique environmental health challenges wildland firefighters face. The review points out the increased risks to safety, health, and well-being from more exposure to natural hazards, identifying key research gaps and priorities. It stresses the need to broaden the geographic and demographic scope of studies, improve analytical methods, and increase research funding and focus for wildland firefighters.

The …

Ontogenetically Driven Changes In The Endocranial Anatomy Of Maiasaura Peeblesorum And Its Implications For Sensory Functions, Emma Puetz

Masters Theses

"Hadrosaurids exhibited extreme morphological diversity and behavioral characteristics that can be compared with other, closely related members of Dinosauria – particularly through the study of neuroanatomy. X-ray CT generated endocrania of the Late Cretaceous saurolophine hadrosaur Maiasaura peeblesorum, known as the “good mother” dinosaur, offers a unique opportunity to compare complex ecological behaviors between non-avian dinosaurs and their modern archosaur relatives. The 3D reconstruction software ORS Dragonfly provided linear and volumetric measurements taken from the digital cranial endocast and endosseous labyrinths of three ontogenetically varied M. peeblesorum specimens from the Two Medicine Formation in Montana that were used to …

Summer Research Fellowship Project Descriptions 2024, Clark Science Center's Summer Research Fellows Program

SURF Abstracts (Women in Science)

A summary of research done by Smith College’s 2024 Summer Research Fellowship (SURF) Program participants. Ever since its 1967 start, SURF has been a cornerstone of Smith’s science education. Supervised by faculty mentor-advisors drawn from the Clark Science Center and connected to its eighteen science, mathematics, and engineering departments and programs and associated centers and units. At summer’s end, SURF participants were asked to summarize their research experiences for this publication.

Fluorotelomer Carboxylic Acid Degradation: Implications For Septic Systems, Alexis Marie Eaton

Honors Theses and Capstones

Per- and polyfluoroalkyl substances, or PFAS, are a group of manmade organic chemicals that have been widely used since the 1940’s due to their resistance to heat, water, and oil. These compounds are associated with negative health outcomes including poor thyroid function, reproductive toxicity, and carcinogenicity. Because products with PFAS are widely used in residential settings, and because many PFAS do not completely degrade during wastewater treatment/handling, septic systems may be an important non-point source of PFAS to groundwater. Many homes that have septic systems, which discharge wastewater effluent to the subsurface, also use groundwater as a drinking water source; …

Comparing Calcium, Vitamin D, And Calorie Intakes Among Unh Army Rotc Cadets With Low And Normal Bone Mineral Status, Ava Gaudette

Honors Theses and Capstones

No abstract provided.

Density Dependent Calling Behavior In North Pacific Humpback Whales, Lucas J. Anderson

Honors Theses and Capstones

Animal density can define factors such as mating success, food acquisition, and communication. Inferring animal density from vocal rates is an important tool for estimating abundance and space use in difficult-to-study species like marine mammals and requires an understanding of the relationship between social context and calling rates. The goal of this project was to investigate the relationship between animal density and call rate in Southeast Alaskan humpback whales (Megaptera novaeangliae). Passive acoustic monitoring data were collected along with visual observations gathered near Frederick Sound and Stephen’s Passage, Southeast Alaska, over two summers (2019, 2022). Observers watched whales …

Assessment Of Open Top Chambers To Simulate Effects Of Climate Change On Soil Temperature And Cover Crop Response In Agricultural Systems, Gretchen Bahmueller

Honors Theses and Capstones

Climate change is expected to yield warmer winters that have the potential to place additional stress on our already stressed agricultural systems. Understanding how agricultural systems may respond to these changes is essential to creating crop and land management plans that ensure food security for future generations. To better understand how warming winters can/will affect air and soil temperatures and cover crop performance, open top chambers (OTCs) were deployed post cover crop seeding in a field experiment at the UNH Kingman Research Farm in Madbury, NH. The experiment consisted of four cover crop treatments sown into or after corn: an …

The Inflation Reduction Act’S Role In Shaping Pharmaceutical Investment Strategies, Grace Harbour

Honors Theses and Capstones

The impact of the Inflation Reduction Act of 2022 on the financial strategies of pharmaceutical companies is the focus of this study, emphasizing research and development and capital expenditures. The act introduces a significant change in U.S. healthcare policy by enabling Medicare to directly negotiate the prices of select drugs. Employing a difference-in-differences analysis framework, this study analyzes data from both treated and control firms from Q1 2020 to Q4 2023 to evaluate the immediate financial responses of pharmaceutical companies to this significant legislative change.

Distribution Of Tick Species On Free-Ranging Ungulates In Northern New England, Karisa Graham

Honors Theses and Capstones

In Northern New England, ungulates are often parasitized by ticks, which is one of the leading causes for the decline in population. Ungulates are a good host for ticks, specifically deer ticks and winter ticks, and these ticks cause many tick-borne diseases in humans as well. The purpose of this study was to assess passive sampling from harvested animals as a means of tick surveillance in Vermont and New Hampshire. Ticks were collected from deer and moose and mapped throughout the two states by ArcGIS to visualize the trends in distribution. Relative abundance was greater in southeastern Vermont, with no …

Supply And Consumption Of Dissolved Organic Phosphorus Across The Subtropical Indian Ocean, Corinne Richard

Honors Theses and Capstones

The Indian Ocean is an understudied region for marine phosphorus (P) biogeochemistry. Emerging evidence indicates marine phytoplankton can adapt to decreasing supplies of inorganic P, a required nutrient for growth, by alternatively utilizing organic forms of P. Here we investigate the dissolved organic phosphorus concentration ([DOP]) distribution across the southern Indian Ocean using observations collected on the I05 US GO-SHIP Cruise (2023) across ~33ºS latitude. We quantify the longitudinal variability of [DOP] in the upper 350 m of the Indian Ocean and infer its rate of biological consumption from surface waters, contributing as an organic nutrient to sustain marine autotrophs …

Investigating The Relationship Between Politics And Education, Alaina M. Winrow

Honors Theses and Capstones

This paper looks into how politics plays a role in the public K-12 education system in the United States, specifically looking at the state of New Hampshire. Federal, state, and local governments provide important resources through funding to schools and create the laws that govern them. However, educational politics can be controversial at times. Within the past several years, there have been more tense school board meetings and divisive laws being passed or considered around the nation. Overall, the divisive political climate has influenced much of the discussion surrounding education and has created more stress for educators, administrators, school staff, …

Do Duckweeds Adapt To Water And Microbes?, Ava M. Rose

Honors Theses and Capstones

Organisms in their home environment sometimes outperform transplanted individuals native to other areas, in a phenomenon termed local adaptation. While local adaptation is traditionally considered to be driven by the abiotic factors of an environment, scientists have recently increased consideration of biotic factors. Specifically, of interest to many is host-associated microbiomes, which can alter host trait expression. As the desire to commercialize microbiome treatments for agriculture and medicine grows, it is important to analyze the potential value of local microbiomes, which may be adapted to their hosts, or to which local hosts may have adapted. Using Lemna minor (duckweed) as …

Artificial Intelligence And The Entertainment Industry, Caroline Rae Mccarthy

Honors Theses and Capstones

Artificial intelligence is a fast-growing technology that is quickly taking over many industries, such as the entertainment industry. Artificial intelligence has the capability to replicate voices, create fake videos and photos, called deepfakes, of just about anything, and can practically bring people back to life. This technology, as it stands now, is similar to the wild west because in the vast majority of places, it’s lawless. Artificial intelligence is growing so rapidly that lawmakers haven’t had a chance to keep up. This paper explains more of what AI does in everyday life, and how its abilities can impact the entertainment …

Investigating The Function Of Protein S-Acyltransferase 2 In Arabidopsis Thaliana Using Crispr Mutants, Nicole Benjamin

Honors Theses and Capstones

Arabidopsis thaliana contains 24 Protein Acyl Transferases (PATs). These enzymes are responsible for catalyzing the addition of a palmitate to a target substrate (palmitoylation). However, beyond its broad enzymatic function, it is unknown how PATs interact on a cellular level. This research focuses on identifying the function of PAT2. CRISPR-Cas9 was used to create deletion mutations that would result in a non-functional PAT. Two plants homozygous for a pat2 deletion were identified: pat2-5 and pat2-6. Preliminary results suggest that pollen grains in both pat2 mutants are larger in both length and width. Additionally, it appears that mutant pollen tends to …

An Updated Outline For Clearing And Staining Of Preserved Specimens, Sadie E. Smith

Honors Theses and Capstones

This protocol outlines a enhanced clearing and staining procedure for persevered specimens, focusing on the visualization of cartilage and bone in small taxa. With origins from O. Shultze's diaphonization methodology in 1897, the process of clearing and staining improves the clarity and contrast of intricate tissues. It is essential for studies in developmental biology, histology and anatomy. This protocol covers the key steps of the process while detailing the materials, solutions and estimated timeline for each step pertaining to specific taxa. The aim of the protocol is to standardize and provide guidance for procedures in the Biological Sciences department at …

Designing A Use-Error Robust Machine Learning Model For Quantitative Analysis Of Diffuse Reflectance Spectra, Allison Scarbrough, Keke Chen, Bing Yu

Biomedical Engineering Faculty Research and Publications

Significance

Machine learning (ML)-enabled diffuse reflectance spectroscopy (DRS) is increasingly used as an alternative to the computation-intensive inverse Monte Carlo (MCI) simulation to predict tissue’s optical properties, including the absorption coefficient,μaand reduced scattering coefficient, μs′.

Aim

We aim to develop a use-error-robust ML algorithm for optical property prediction from DRS spectra.

Approach

We developed a wavelength-independent regressor (WIR) to predict optical properties from DRS data. For validation, we generated 1520 simulated DRS spectra with the forward Monte Carlo model, where μa=0.44 to 2.45cm−1, and μs′=6.53 to 9.58cm−1. We introduced common use-errors, such as wavelength miscalibrations and intensity fluctuations. Finally, we …

In Situ High Temperature Fiber-Optic Raman Sensor For Industrial Applications, Bohong Zhang

Doctoral Dissertations

"Continuous casting in steel production uses specially developed oxyfluoride glasses (mold fluxes) to lubricate a mold and control the solidification of the steel in the mold. The composition of the flux impacts properties, including basicity, viscosity, and crystallization rate, all of which affect the stability of the casting process and the quality of the solidified steel. However, mold fluxes interact with steel during the casting process, resulting in flux chemistry changes that must be considered in the flux design. Currently, the chemical composition of mold flux must be determined by extracting flux samples from the mold during casting and then …