Digital Commons Network^™

Tumor-Infiltrating Mast Cells Confer Resistance To Immunotherapy In Pancreatic Cancer, Ying Ma, Xiangqin Zhao, Jingyan Feng, Suimin Qiu, Baoan Ji, Lu Huang, Patrick Hwu, Craig D Logsdon, Huamin Wang

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) exhibits an immunosuppressive tumor microenvironment (TME) contributing to its therapeutic resistance. Following our previous studies, we report that mast cells infiltrating the PDAC TME foster this immunosuppression and desmoplasia. Mast cell infiltration correlated with human PDAC progression, and genetic or pharmacological mast cell depletion reduced tumor growth and desmoplasia while enhancing survival in mouse PDAC models. Mechanistically, mast cell-derived IL-10 promoted PDAC progression. Strikingly, combining an agonistic anti-OX40 immunotherapy with mast cell blockade synergistically elicited durable anti-tumor immunity, marked by increased infiltration of CD8

Warrior Women And Trans Warriors: Performing Masculinities In Twentieth-Century Latin American Literature, Carolina Castellanos Gonella

Purdue Studies in Romance Literatures

Latin American literature has depicted warrior woman and trans warrior characters in armed conflicts, but literary critics have not paid much attention to their empowerment. They also have critiqued these characters using traditional gender binary concepts or have viewed their access to power as evil or abnormal. Warrior Women and Trans Warriors: Performing Masculinities in Twentieth-Century Latin American Literature introduces a new perspective by analyzing how one trans warrior and two warrior women from three canonical novels contest traditional codes of behavior and appearance. It examines Pintada in the Mexican novel Los de abajo (1915); doña Bárbara in the Venezuelan …

Powering Up Clinical Practice: Mastering Clinical Literature Search Techniques In Embase, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation titled "Powering Up Clinical Practice: Mastering Clinical Literature Search Techniques in EMBASE" is a workshop designed to enhance healthcare professionals' skills in conducting effective clinical literature searches. It covers navigating EMBASE, transforming clinical questions into search concepts, developing advanced search strategies using keywords and Emtree terms, and applying techniques to optimize and evaluate search results. The workshop aims to improve participants' ability to efficiently utilize EMBASE for clinical decision-making and research purposes.

Industrial Hemp Biomass Negatively Affected By Herbicide Drift From Corn And Soybean Herbicides, Milos Zaric, Bruno Canella Vieira, Barbara Houston, Guilherme Sousa Alves, Samuel E. Wortman, Julie A. Peterson, Greg R. Kruger

Department of Agronomy and Horticulture: Faculty Publications

The establishment of industrial hemp (Cannabis sativa L.) fields near row crops has raised concerns about the potential adverse effects of herbicide drift on hemp production. This study examined hemp susceptibility to drift of herbicides registered for use in corn and/or soybeans. Herbicide solutions (2,4-D, dicamba, glufosinate, glyphosate, imazethapyr, lactofen, mesotrione) were applied separately in the wind tunnel (3.6 m s⁻¹ airspeed), simulating drift scenarios, with conventional TP95015EVS (TP) and air inclusion AI95015EVS (AI) flat fan nozzles calibrated to deliver 140 L ha⁻¹ carrier volume at 230 kPa. Mylar cards and hemp plants (20–25 cm tall) were placed …

Identifying Hidden Factors Influencing Soil Olsen-P In An Alkaline Calcareous Soil Using Machine Learning And Geostatistical Techniques, Moussa Bouray, Mohammed Bayad, Adnane Beniaich, Ahmed G. El-Naggar, Rebecca Muenich, Kahlil El Mejahed, Abdallah Oukarroum, Mohamed El Gharous

Biological and Agricultural Engineering Faculty Publications and Presentations

Phosphorus (P) deficiency is one of the major constraints for sustainable crop production in calcareous soils. This study aimed to elucidate the key soil characteristics modulating the variability of soil Olsen P in these typical soils. A comprehensive soil sampling initiative (1.5 samples per hectare) was conducted on a 100-ha farm, considering 31 attributes that included soil physical and chemical properties, and geographic attributes. Three machine learning algorithms—partial least squares regression (PLSR), random forest (RF), and cubist regression (CR)—were employed to understand key variables controlling soil Olsen P. Furthermore, the same data set was used to spatially map the …

Ionic Nanomedicines And Biocompatible Hydrogel: Synthesis, Characterization And Application In Cancer And Drug Delivery, Mujeebat Bashiru

Theses and Dissertations

This dissertation is focused on the development of novel class of ionic materials (IMs), and ionic nanomedicines (INMs) for cancer treatment. These IMs are composed of two therapeutics combined via electrostatic attraction. The impact of various counterions on the drug’s cytotoxic and photophysical properties are unveiled. Moreover, the mechanism of internalization, enhanced toxicity of these materials is investigated by determining their cellular uptake, subcellular localization, and cell death mechanism. Furthermore, the in vivo bioimaging capabilities of the drugs is investigated to validate their potential for clinical relevance. The second part of this dissertation is focused on the synthesis of biocompatible …

Moderating Effect Of Urban/Rural Status, State Of Residence, And Health Risk Factors On Maternal Mortality Among Different Races, Emmanuel Agubata

Walden Dissertations and Doctoral Studies

Maternal mortality in the United States is significantly higher than in most developed nations and has been increasing since 2000. Persistent between-group disparities among White, Black, and Hispanic women occur in terms of maternal mortality; however, the reason for this is largely unknown. Using the intersectionality theory, this quantitative study examined if racial groups predicted maternal mortality and to what extent relationships were moderated by geographic area and health risk factors. This nonexperimental correlational historical research design addressed three research questions. The Healthcare Cost and Utilization Project dataset was used for the analysis. The minimum sample size was 988 cases, …

Teaching Sbirt To Nurses In A Mental Health Setting For Improved Assessment And Management Of Patients With Substance Use Disorders, Kifle Gashie Jikamo

Walden Dissertations and Doctoral Studies

Addressing the knowledge gap is essential in nursing practice, as RNs are the first point of contact for patients in mental health settings where substance use significantly influences overall health and recovery. This Doctor of Nursing Practice project focused on the need for staff education in an inpatient mental health unit regarding the assessment and triage of patients with substance use disorders (SUDs). The guiding question for this project was: “In nurses working within an inpatient mental health setting, does the implementation of Screening, Brief Intervention, and Referral to Treatment (SBIRT) training improve knowledge in assessing, managing, and providing care …

Assessing Mechanical Agency During Apical Apoptotic Cell Extrusion, Sommer Anjum, Llaran Turner, Youmna Atieh, George T Eisenhoffer, Lance A Davidson

Faculty, Staff and Student Publications

Homeostasis is necessary for epithelia to maintain barrier function and prevent the accumulation of defective cells. Unfit, excess, and dying cells in the larval zebrafish tail fin epidermis are removed via controlled cell death and extrusion. Extrusion coincides with oscillations of cell area, both in the extruding cell and its neighbors. Here, we develop a biophysical model of this process to explore the role of autonomous and non-autonomous mechanics. We vary biophysical properties and oscillatory behaviors of extruding cells and their neighbors along with tissue-wide cell density and viscosity. We find that cell autonomous processes are major contributors to the …

Epigenome Reprogramming Through H3k27 And H3k4 Trimethylation As A Resistance Mechanism To Dna Methylation Inhibition In Brafv600e-Mutated Colorectal Cancer, Hey Min Lee, Ajay Kumar Saw, Van K Morris, Stefania Napolitano, Christopher Bristow, Sanjana Srinivasan, Micheal Peoples, Alexey Sorokin, Preeti Kanikarla Marie, Jonathan Schulz, Anand K Singh, Christopher Terranova, Oluwadara Coker, Abhinav Jain, Scott Kopetz, Kunal Rai

Faculty, Staff and Student Publications

Purpose: BRAFV600E-mutated colorectal cancer exhibits a strong correlation with DNA hypermethylation, suggesting that this subgroup of tumors presents unique epigenomic phenotypes. Nonetheless, 5-azacitidine, which inhibits DNA methyltransferase activity, is not efficacious in BRAFV600E colorectal cancer in vivo.

Experimental design: We randomized and treated mice implanted with patient-derived tumor xenografts harboring BRAFV600E mutation with control, 5-azacitidine, vemurafenib (BRAF inhibitor), or the combination. Comprehensive epigenomic profiling was conducted on control and 5-azacitidine-treated tumor samples, including DNA methylation, histone modifications, chromatin accessibility, and gene expression. Combinations of epigenetic agents were explored in preclinical BRAFV600E colorectal cancer models.

Results: A profound reduction of DNA …

Optimization Processes Of Clinical Chelation-Based Radiopharmaceuticals For Pathway-Directed Targeted Radionuclide Therapy In Oncology, Katsumi Tomiyoshi, Lydia J. Wilson, Firas Mourtada, Jennifer Sims Mourtada, Yuta Namiki, Wataru Kamata, David J. Yang, Tomio Inoue

Department of Radiation Oncology Faculty Papers

Targeted radionuclide therapy (TRT) for internal pathway-directed treatment is a game changer for precision medicine. TRT improves tumor control while minimizing damage to healthy tissue and extends the survival for patients with cancer. The application of theranostic-paired TRT along with cellular phenotype and genotype correlative analysis has the potential for malignant disease management. Chelation chemistry is essential for the development of theranostic-paired radiopharmaceuticals for TRT. Among image-guided TRT,

Spatiotemporal Dynamics Of Coastal Nekton Metacommunities In The Western Atlantic, Jonathan A. Peake

USF Tampa Graduate Theses and Dissertations

The processes of diversification, selection, dispersal, and stochastic drift can combine in many ways to assemble ecological communities. A key focus in ecology is to describe and quantify the relative influences of these processes for different systems and explain the mechanisms by which these processes produce patterns of community structure. To accomplish this goal, ecologists have developed several frameworks that seek to integrate processes that occur locally andregionally. The metacommunity concept treats local communities as pieces of a broader landscape that are connected through dispersal of their constituent organisms. Empirical studies have generally lagged behind the development of metacommunity theory. …

Numerical Modelling Of Atoll Island Flooding And Implications For The Future: The 1 July 2022 Island Flooding Event, Southwest Huvadhoo Atoll, Maldives, Gerd Masselink

Faculty of Science and Engineering Datasets

Field data and numerical model data and model parameters

Association Of Clonal Hematopoiesis And Mosaic Chromosomal Alterations With Solid Malignancy Incidence And Mortality, Pinkal Desai, Ying Zhou, Justin Grenet, Samuel K Handelman, Cynthia M Crispino, Laura N Tarbay, Eric A Whitsel, Gail Roboz, Ana Barac, Michael Honigberg, Alexander Bick, Garnet Anderson, Jean Wactawski-Wende, Yasminka A Jakubek Swartzlander, Jason Bacon, Justin Wong, Xiaolong Ma, Paul Scheet, Zichan Li, Pashtoon Kasi, Ross Prentice, Paul Auer, Joann E Manson, Alexander Reiner, Michael Simon

Faculty, Staff and Student Publications

Background: Understanding the impact of clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) on solid tumor risk and mortality can shed light on novel cancer pathways.

Methods: The authors analyzed whole genome sequencing data from the Trans-Omics for Precision Medicine Women's Health Initiative study (n = 10,866). They investigated the presence of CHIP and mCA and their association with the development and mortality of breast, lung, and colorectal cancers.

Results: CHIP was associated with higher risk of breast (hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.03-1.64; p = .02) but not colorectal (p = .77) or …

Disease Site Specialization In The Academic Radiation Oncology Workforce: Evidence Of Gender Differences, Kelsey L Corrigan, Mikaela E Bankston, Emma B Holliday, Simona F Shaitelman, Anna Lee, Chelain R Goodman, C David Fuller, Fumiko L Chino, Charles R Thomas, Reshma Jagsi, Ethan B Ludmir

Faculty, Staff and Student Publications

Purpose: Because some stakeholders within medicine seek to diversify and attain greater workforce equity, it is critical to understand gender-based divisions within specialization. Radiation oncology (RO) has one of the smallest proportions of women representation of all specialties, and to our knowledge, no prior studies have investigated gender differences in all the disease site specializations within RO. Thus, we analyzed the relationship between gender and disease site(s) treated in academic RO (ARO).

Methods and materials: Faculty gender and disease site(s) treated by faculty from ARO departments were collected via publicly available department websites in January 2020. X2 analyses were conducted …

Low-Molecular Weight Cyclin E Confers A Vulnerability To Pkmyt1 Inhibition In Triple-Negative Breast Cancer, Mi Li, Amriti R Lulla, Yan Wang, Spyros Tsavaschidis, Fuchenchu Wang, Cansu Karakas, Tuyen D T Nguyen, Tuyen N Bui, Marc A Pina, Mei-Kuang Chen, Sofia Mastoraki, Asha S Multani, Natalie W Fowlkes, Aysegul Sahin, C Gary Marshall, Kelly K Hunt, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin E is a regulatory subunit of CDK2 that mediates S phase entry and progression. The cleavage of full-length cyclin E (FL-cycE) to low-molecular weight isoforms (LMW-E) dramatically alters substrate specificity, promoting G1-S cell cycle transition and accelerating mitotic exit. Approximately 70% of triple-negative breast cancers (TNBC) express LMW-E, which correlates with poor prognosis. PKMYT1 also plays an important role in mitosis by inhibiting CDK1 to block premature mitotic entry, suggesting it could be a therapeutic target in TNBC expressing LMW-E. In this study, analysis of tumor samples of patients with TNBC revealed that coexpression of LMW-E and PKMYT1-catalyzed CDK1 …

Personalized Composite Dosimetric Score-Based Machine Learning Model Of Severe Radiation-Induced Lymphopenia Among Patients With Esophageal Cancer, Yan Chu, Cong Zhu, Brian P Hobbs, Yiqing Chen, Peter S N Van Rossum, Clemens Grassberger, Degui Zhi, Steven H Lin, Radhe Mohan

Faculty, Staff and Student Publications

Purpose: Radiation-induced lymphopenia (RIL) is common among patients undergoing radiation therapy (RT)' Severe RIL has been linked to adverse outcomes. The severity and risk of RIL can be predicted from baseline clinical characteristics and dosimetric parameters. However, dosimetric parameters, e.g. dose-volume (DV) indices, are highly correlated with one another and are only weakly associated with RIL. Here we introduce the novel concept of "composite dosimetric score" (CDS) as the index that condenses the dose distribution in immune tissues of interest to study the dosimetric dependence of RIL. We derived an improved multivariate classification scheme for risk of grade 4 RIL …

Biological Control For One Health, Urs Schaffner, George E. Heimpel, Nicholas J. Mills, Beatrice W. Muriithi, Matthew B. Thomas, Yubak D. Gc, Kris A.G. Wyckhuys

All Peer-Reviewed Publications

Biological control has been effectively exploited by mankind since 300 CE. By promoting the natural regulation of pests, weeds, and diseases, it produces societal benefits at the food-environment-health nexus. Here we scrutinize biological control endeavours and their social-ecological outcomes through a holistic ‘One-Health’ lens, recognizing that the health of humans, animals, plants, and the wider environment are linked and interdependent. Evidence shows that biological control generates desirable outcomes within all One Health dimensions, mitigating global change issues such as chemical pollution, biocide resistance, biodiversity loss, and habitat destruction. Yet, its cross-disciplinary achievements remain underappreciated. To remedy this, we advocate a …

Clonal Hematopoiesis And Solid Tumor Risk: New Insights From The Women's Health Initiative, Nehali Shah, Koichi Takahashi

Faculty, Staff and Student Publications

No abstract provided.

Numerical Taxonomic Study Of Some Cultivars Species Of The Genus Bougainvillea Comm. Ex Juss. Cultivated In Nineveh Governorate / Iraq, Raad Hamad Mahmood Al-Badrany

Baghdad Science Journal

The current study included the numerical taxonomy cultivars species of the genus Bougainvillea Comm. ex Juss. Cultivated in Nineveh/Iraq, consists of the cultivars of B. glabra Choisy species: (‘Formosa’, ‘Lesser’, ‘Royal purple’, ‘Sanderiana’) and the cultivar ‘Mary palmer’ of the B. spectibilis Willd species, ‘Thimma’ cultivar of B. peraviana Hum. and Bon species., ‘California gold’ and ‘Cherry blossom’ cultivars of B. X buttiana species using the morphological characteristics. 12 qualitative morphological traits were selected to draw the polygonal diagrams for all cultivars under study and 27 morphological traits 7 quantitative and 20 qualitative were compared for cultivars species of the …

Are Ai Tools Better Than Traditional Tools In Literature Searching? Evidence From E-Commerce Research, Maria Petrescu, Przemysław Tomczyk, Philipp Brüggemann, Niklas Mergner

Publications

This article examines the potential implications of Artificial Intelligence (AI) for literature search, comparing AI-based tools to conventional research methods. It also addresses the scarcity of academic literature on specific AI tools for research writing, posing four critical questions regarding accuracy, quality, uniqueness, and qualified uniqueness. Employing Algorithmic Theory and Data Dependency Theory, this project scrutinizes AI performance in algorithms, machine learning models, and data quality. Testing nine e-commerce topics using Scopus, Web of Science, Elicit, and SciSpace, the authors conclude that while conventional methods excel in accuracy and quality, AI tools show promise in uniqueness, complementing literature reviews. The …

Restorative Function Of Offshore Longline Mussel Farms With Ecological Benefits For Commercial Crustacean Species, Thomas Stamp, Simon J. Pittman, Luke A. Holmes, Adam Rees, Benjamin J. Ciotti, Harry Thatcher, Peter Davies, Alice Hall, Georgia Wells, Anna Olczak, Emma V. Sheehan

School of Biological and Marine Sciences

Offshore ocean aquaculture is expanding globally to meet the growing demand for sustainable food production. At the United Kingdom's largest longline mussel farm, we assessed the potential for the farm to improve the habitat suitability for commercially important crustaceans. Modelled distribution patterns (GAM & GLM) predicted the low complexity seabed beneath the mussel farm was 34–94 % less suitable for European lobster (Homarus gammarus) and brown crab (Cancer pagurus) than nearby rocky reefs. The mussel farm operations, however, contributed large amounts of living mussels and shell material to the seabed. Acoustic telemetry revealed that H.gammarus remained within the farm for …

Factors That Influence Colostrum Yield: Dry Period Length, Peter S. Erickson

UNH Cooperative Extension

No abstract provided.

Issues And Challenges Of Exporting Malaysia Musang King Durian To China, Swee Keong Goh, Jamalludin Helmi Hashim, Shirley Sie Ling Tan

Jesselton Journal of Educators and Scholars

This project paper is to analyse and understand Musang King Durian (MSKD) for its fruit, plantation, and market, especially its export to the China market. A comparison is also made with Thailand’s Monthong durian. Research findings are used to recommend solutions to the identified challenges. Porter’s Five Forces model and SCCMT are applied to provide in-depth figures supporting the proposed recommendations. The study includes a projection of China’s durian market size in 2030, identifying that Malaysia’s MSKD is capable of achieving 10 percent of China’s market share. This achievement is significant for Malaysia’s MSKD plantation industry. The research aims to …

An Investigation Into Consumers’ Perceptions Of Electronic Payment In Malaysia, Hao Fung Zhun, Javan Elfe Ginajil, Hong Tat Teh

Jesselton Journal of Educators and Scholars

The purpose of this study is to examine how consumers view electronic payment systems. The researcher has chosen to examine five factors that might affect consumers’ perception towards electronic payment: benefit, ease of use, self-efficacy, trust, and security. This study has advanced knowledge as it provides information on the current state of e-payment acceptance and use, particularly among Malaysians. The significant factors identified are beneficial to policymakers, banking institutions, online transaction facilities providers, and software developers as they develop strategies aimed at increasing e-payment acceptance and use.

Vertical Arrays Of Artificial Rockpools On A Seawall Provide Refugia Across Tidal Levels For Intertidal Species In The Uk, Jessica R. Bone, Rick Stafford, Alice E. Hall, Roger J.H. Herbert

School of Biological and Marine Sciences

Eco-engineering of coastal infrastructure aims to address the insufficient intertidal habitat provided by coastal development and flood defence. There are numerous ways to enhance coastal infrastructure with habitat features, but a common method involves retrofitting artificial rockpools. Often these are ‘bolt-on’ units that are fixed to existing coastal infrastructure but there is a paucity of literature on how to optimise their arrangement for biodiversity. In this study, 24 artificial rockpools were installed at three levels between High Water Neaps and Mean Tide Level on a vertical concrete seawall on the south coast of the UK. The species abundance of the …

Radiological And Elemental Composition Of Cryoconite And Glacier Mice From Vatnajökull, Iceland, Emma Smith, Caroline Clason, Geoff Millward, Alex Taylor, Ralph Fyfe

School of Geography, Earth and Environmental Sciences

Cryoconite has been demonstrated to be an efficient accumulator of some classes of contaminants on glaciers in both mountain and polar environments, however the accumulation of contaminants in cryoconite in Iceland has received very little attention to date. To understand the spatial variability of natural and anthropogenic fallout radionuclides and metals on glaciers in Iceland, we present the first study of this region including both cryoconite from three glaciers: Virkisjökull; Skaftafellsjökull; and Falljökull, together with moss balls (‘glacier mice’) from Falljökull. The cryoconite samples and glacier mice were analysed using XRF spectrometry to assess their elemental composition and gamma spectrometry …

Update On Recommendations For Cancer Screening And Surveillance In Children With Genomic Instability Disorders, Yoshiko Nakano, Roland P Kuiper, Kim E Nichols, Christopher C Porter, Harry Lesmana, Julia Meade, Christian P Kratz, Lucy A Godley, Luke D Maese, Maria Isabel Achatz, Payal P Khincha, Sharon A Savage, Andrea S Doria, Mary-Louise C Greer, Vivian Y Chang, Lisa L Wang, Sharon E Plon, Michael F Walsh

Center for Medical Ethics and Health Policy Staff Publications

Genomic instability disorders are characterized by DNA or chromosomal instability, resulting in various clinical manifestations, including developmental anomalies, immunodeficiency, and increased risk of developing cancers beginning in childhood. Many of these genomic instability disorders also present with exquisite sensitivity to anticancer treatments such as ionizing radiation and chemotherapy, which may further increase the risk of second cancers. In July 2023, the American Association for Cancer Research held the second Childhood Cancer Predisposition Workshop, where multidisciplinary international experts discussed, reviewed, and updated recommendations for children with cancer predisposition syndromes. This article discusses childhood cancer risks and surveillance recommendations for the group …

Therapeutic Effect Of Recombinant Echinococcus Granulosus Antigen B Subunit 2 Protein On Sepsis In A Mouse Model, Ya-Yun Qian, Fei-Fei Huang, Si-Yu Chen, Wei-Xiao Zhang, Yin Wang, Peng-Fei Du, Gen Li, Wen-Bo Ding, Lei Qian, Bin Zhan, Liang Chu, Dong-Hui Jiang, Xiao-Di Yang, Rui Zhou

Faculty, Staff and Students Publications

BACKGROUND: Sepsis is a potentially fatal systemic inflammatory response syndrome (SIRS) that threatens millions of lives worldwide. Echinococcus granulosus antigen B (EgAgB) is a protein released by the larvae of the tapeworm. This protein has been shown to play an important role in modulating host immune response. In this study we expressed EgAgB as soluble recombinant protein in E. coli (rEgAgB) and explored its protective effect on sepsis.

METHODS: The sepsis model was established by cecal ligation and puncture (CLP) procedure in BALB/c mice. The therapeutic effect of rEgAgB on sepsis was performed by interperitoneally injecting 5 µg rEgAgB in …

Lung Tissue Multilayer Network Analysis Uncovers The Molecular Heterogeneity Of Chronic Obstructive Pulmonary Disease, Nuria Olvera, Jon Sánchez-Valle, Iker Núñez-Carpintero, Joselyn Rojas-Quintero, Guillaume Noell, Sandra Casas-Recasens, Alen Faiz, Philip Hansbro, Angela Guirao, Rosalba Lepore, Davide Cirillo, Alvar Agustí, Francesca Polverino, Alfonso Valencia, Rosa Faner

Faculty, Staff and Students Publications

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition. Objectives: We hypothesized that the unbiased integration of different COPD lung omics using a novel multilayer approach might unravel mechanisms associated with clinical characteristics.

Methods: We profiled mRNA, microRNA and methylome in lung tissue samples from 135 former smokers with COPD. For each omic (layer), we built a patient network on the basis of molecular similarity. The three networks were used to build a multilayer network, and optimization of multiplex modularity was used to identify patient communities across the three distinct layers. Uncovered communities were related to clinical features.

Measurements …