Digital Commons Network^™

Landscape Character Analysis And Assesment At Local Scale, Eli̇f Önal, Serkan Özer

Turkish Journal of Agriculture and Forestry

​Landscape areas are one of the most important elements of human life all over the world. Varied landscape areas are a valuable natural resource and have high cultural value. The first step to ensure the effective landscape use is to identify these areas, analyze them in detail, and determine their characteristics. The northeastern Anatolia region in Türkiye has a rich diversity of landscapes because of varied geographic, climatic, and topographic features. The aim of this study was to identify the landscape character types in the Tortum district, located in the Tortum River basin in northeastern Türkiye, and to assess the …

Male Osteoporosis: Pathophysiology, Risk Assessment, And Evidence-Based Management, Seli̇n Teki̇n, Alper Gürlek

Turkish Journal of Medical Sciences

Osteoporosis in men is a common yet underrecognized condition associated with substantial fracture-related morbidity and excess mortality. Although men generally attain higher peak bone mass than women, age-related changes in bone microarchitecture, progressive cortical bone loss, declining sex steroid bioavailability, and a high prevalence of secondary causes contribute to a significant lifetime fracture risk. Importantly, a large proportion of fragility fractures in men occur at bone mineral density (BMD) values above the osteoporotic threshold, highlighting the limitations of BMD-based diagnosis alone. This review provides a comprehensive overview of the epidemiology, pathophysiology, and clinical characteristics of osteoporosis in men, with particular …

Direct Pars Repair Techniques For Lumbar Spondylolysis: A Comparative Literature Review ​, Kami̇l C. Kose, Moustafa Ibrahim, Ni̇cholas D. Haden, John Afolayan, Hanny Anwar

Turkish Journal of Medical Sciences

Background/aim: Lumbar spondylolysis, a pars interarticularis defect affecting approximately 3%–6% of the general population, presents a significant clinical challenge in young adults and athletes. When conservative management fails, direct pars repair offers an attractive alternative to spinal fusion by preserving segmental motion and reducing the risk of adjacent segment degeneration. This narrative review compares seven principal direct pars repair techniques—Buck’s technique, Scott’s wiring method, Morscher’s hook-screw system, pedicle screw-based constructs, the V-rod/U-rod (Gillet technique), the smiley face rod construct, and the dualstability construct (DSC)—evaluating their biomechanical properties, clinical outcomes, fusion rates, and complication profiles.

Materials and methods: A narrative literature …

Preserved Inflammatory Homeostasis During Emergency Transport: A Multibiomarker Assessment Of Neonatal Rds Transfers ​, Eyüp Sari, Şeri̇fe Suna Oğuz, Mehmet Semi̇h Demi̇rtaş, Bensu Bulut, Medi̇ne Akkan Öz, Murat Genç, Ayşenur Gür, Ümi̇t Alper Özcan, Hüseyi̇n Mutlu, Rami̇z Yazici

Turkish Journal of Medical Sciences

Background/aim: The aim was to compare the pre- and posttransport levels of systemic inflammatory markers in neonatal infants transported to a tertiary intensive care unit via emergency health services with a neonatal respiratory distress syndrome (nRDS) diagnosis and to assess the quality of transport.

Materials and methods: This retrospective study was conducted between January 2019 and December 2023. A total of 117 nRDS patients’ emergency transports were included in the study. Demographic data, transfer time, intubation, cold treatment, cardiopulmonary resuscitation (CPR), and pre- and posttransport laboratory parameters were obtained retrospectively. The statistical analysis was performed using IBM SPSS Statistics (Version …

Association Of Occupational Lead Exposure With Erythrocytic Parameters And Nitric Oxide–Related Metabolites: A Case-Control Study ​​, Meli̇h Gaffar Gözükara, Servet Bi̇rgi̇n İri̇taş, Deni̇z Özkan Vardar, Lütfi̇ye Tutkun, Özlem İri̇taş, Serdar Deni̇z, Vugar Ali̇ Türksoy, Engi̇n Tutkun

Turkish Journal of Medical Sciences

Background/aim: Occupational lead (Pb) exposure remains a significant public health concern due to its persistent presence in industrial environments and its cumulative toxic effects. Although the hematological and neurological consequences of Pb exposure are well documented, early vascular effects and the mechanisms associated with potential endothelial impairment remain unclear. This study aimed to investigate the associations between Pb exposure, erythrocytic parameters, and nitric oxide (NO)–related metabolites (asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA], arginine, homoarginine, and citrulline) to identify early biomarkers that may suggest impairment in NO-related pathways.

Materials and methods: This case-control study included a strictly selected cohort of 125 …

Influenza, Covid-19, And Pneumococcal Vaccination Status Among Adults In Türkiye ​, Gamze Şanlidağ İşbi̇len, Serap Gençer, Hüsnü Pullukçu, Meltem Taşbakan, İftahar Köksal

Turkish Journal of Medical Sciences

Background/aim: Vaccines reduce morbidity and mortality caused by infectious diseases that threaten public health. Lifelong immunization programs are essential for the entire population. This study assessed adult vaccination uptake for influenza, pneumococcal, and coronavirus disease 2019 (COVID-19) vaccines in Türkiye and examined the barriers and factors influencing vaccination decisions.

Materials and methods: This cross-sectional survey was designed and conducted by the Immunization Working Group of the Turkish Society of Clinical Microbiology and Infectious Diseases. A 19-item questionnaire was administered to individuals aged 18 years or older to assess influenza, pneumococcal, and COVID-19 vaccination status. The questionnaire collected data on demographic …

Erratum To “Effects Of Colchicine On Sah-Induced Vascular Damage In An Experimental Subarachnoid Hemorrhage Model’’ [Turkish Journal Of Medical Sciences 56 (2) 2026 597-607] ​, Emi̇ne Demi̇r, Cumaali̇ Demi̇rtaş, Cansu Sönmez, Eray Meti̇n Güler, Sarper Kocaoğlu, Hakan Beyaztaş, Eyüp Çeti̇n

Turkish Journal of Medical Sciences

The original article can be accessed at https://doi.org/10.55730/1300-0144.6192.

Background/aim: Subarachnoid haemorrhage (SAH) is a severe cerebrovascular condition with high morbidity and mortality. Inflammation and oxidative stress are key factors in its pathophysiology, particularly in secondary vascular injury. This study aimed to evaluate the effects of colchicine on vascular integrity and biochemical markers following SAH in an experimental rat model.

Materials and methods: Eighteen female Sprague-Dawley rats were divided into three groups: Control (no SAH), SAH (induced without treatment), and SAH + Colchicine (1 mg/kg intraperitoneally at 1 h and 24 h). SAH was induced by autologous blood injection into …

The Lived Experiences Of Intimacy And Isolation In Single Mothers During Covid-19: An Eriksonian Perspective, Chante Renee Reeves

Walden Dissertations and Doctoral Studies

Single mothers were largely absent from the COVID-19 literature, despite being head of household in approximately 80% of single-parent homes. The purpose of this phenomenological qualitative research study was to gain insight into the lived experiences of single mothers during the COVID-19 pandemic. This study addressed how this group connected with family, friends, and others in meaningful ways despite government-imposed lockdowns and restrictions. This phenomenon was explored through Erik Erikson’s psychosocial development theory, with a focus on the intimacy versus isolation stage. An Eriksonian perspective on relationship building and maintenance in adulthood can help better understand and address the social …

Completion Outcomes And Predictive Characteristics In Mandated Inpatient Substance Use Treatment, Tina Marie Moyer

Walden Dissertations and Doctoral Studies

Treatment retention, specifically as it pertains to offenders who are mandated to receive substance use treatment rather than serve standard incarceration sentences, is receiving more scholarly attention. Although prior research indicates an association between substance use treatment and reduced criminal behavior, many studies have methodological limitations. The purpose of this quantitative non-experimental, comparative study was to compare treatment completion outcomes for mandated and non-mandated offenders and to examine individual predictors of treatment completion, thereby addressing gaps in the current research. Secondary data from adult offenders receiving treatment at an inpatient substance use rehabilitation facility were analyzed. The risk-needs-responsivity model was …

Daam2 Gene Variants P.(Asp165glu) And P.(Asn614thrfster2) In Pediatric Cryptorchidism: A Hypothesis-Generating Pilot Case-Control Study From The Eastern Black Sea Region Of Türkiye ​, Onur Yalçin, Çağri Doğan

Turkish Journal of Medical Sciences

Background/aim: Cryptorchidism is the most common congenital anomaly of the male genitourinary system, characterized by a multifactorial etiology. The disheveled-associated activator of morphogenesis 2 (DAAM2) gene regulates androgen receptor (AR)- dependent transcription; its variants are associated with partial androgen insensitivity. Since the inguinoscrotal phase of testicular descent is androgen-dependent, we hypothesized that DAAM2 variants contribute to cryptorchidism susceptibility. This pilot study, designed to generate hypotheses rather than to establish association, investigated the frequency of two functionally characterized DAAM2 variants, p.(Asp165Glu) and p.(Asn614ThrfsTer2), in pediatric cryptorchidism.

Materials and methods: This prospective case-control study included 40 male pediatric cryptorchidism patients and 39 …

Thyroid Function In Children With Attention-Deficit/Hyperactivity Disorder And Specific Learning Disorder: A Retrospective Comparative Study, Gül Trabzon, Seda Aybüke Sari, Servet Yüce, Şeyma Demi̇ray Güllü

Turkish Journal of Medical Sciences

Background/aim: This study analyzes thyroid function parameters (free T₃, free T₄, TSH) in children with attention-deficit/hyperactivity disorder (ADHD), ADHD with specific learning disorder, and healthy controls, to determine whether subtle thyroid dysregulation contributes to the phenotypic heterogeneity of ADHD.

Materials and methods: This retrospective, cross-sectional study included 135 children aged 6–18 years: 62 diagnosed with ADHD (38 isolated ADHD and 24 ADHD+SLD) and 73 healthy controls. Demographic, anthropometric, and thyroid function data (free T₃, free T₄, TSH) were extracted from medical records. Group comparisons were conducted using independent samples t-tests, ANOVA, and ANCOVA adjusted for age, sex, and treatment status. …

Sarcopenia Risk In Women With Postmenopausal Osteoporosis: A Sarc-F-Based Assessment ​, Burak Kami̇l Turan, Ayşe Adi̇le Küçükdeveci̇, Zafer Günendi̇, Ayşegül Yaman, Oya Özdemi̇r, Jale Meray, Fatma Yeşi̇m Gökçe Kutsal

Turkish Journal of Medical Sciences

Background/aim: Osteoporosis and sarcopenia are diseases of bone and muscle tissue, respectively. Studies reported that these disorders were interrelated. However, this relation was explored in older adults and/or with certain comorbidities, and information about nonelderly postmenopausal women is scarce. This study’s objectives were to investigate the relationship between osteoporosis and SARC-F-defined sarcopenia risk in postmenopausal women aged ≤70 years and to examine the effect of other factors on this risk.

Materials and methods: This multicenter case-control study included postmenopausal women aged 45–70 years. Dual-energy X-ray absorptiometry was utilized to diagnose osteoporosis. Sociodemographic and clinical variables, sarcopenia risk (SARC-F), muscle strength …

Can Hydrolyzed Silk Fibroin Derived From Bombyx Hatayensis And Ozonized Gel Modulate Inflammatory And Angiogenic Responses In A Corneal Alkali Burn Model? ​​, Şule Barman Kaki̇l, Hamdullah Suphi̇ Bayraktar, Okan Soylu, İshak Gökçek, Meryem İlkay Karagül, Zehra Demi̇ray Asoğlu

Turkish Journal of Medical Sciences

Background/aim: The therapeutic effects of hydrolyzed silk fibroin derived from Bombyx hatayensis and a commercially available ozonized gel, administered individually and in combination, were evaluated in a rat model of corneal alkali burn.

Materials and methods: A standardized corneal alkali burn was induced in the right eyes of Wistar albino rats using 1 N sodium hydroxide (NaOH). Animals were randomly assigned to six groups: negative control, positive control (PC), hydrolyzed silk fibroin (SF), ozonized gel (O), combined treatment (SF + O), and antibiotic treatment. Topical treatments were administered for 21 consecutive days. Clinical evaluation included assessments of corneal opacity, neovascularization, …

Repurposing Diclofenac For Combination Therapy: Targeting The Warburg Effect To Enhance Breast Cancer Treatment ​, Gonca Tuna, Eli̇f Ertürk, Ayşen Sağnak, Ferda Ari

Turkish Journal of Medical Sciences

Background/aim: Diclofenac (Diclo), a widely used nonsteroidal antiinflammatory drug, has emerged as a potential candidate for drug repurposing in oncology, with reported anticancer effects extending beyond cyclooxygenase (COX) inhibition, including modulation of tumor metabolism. This study investigated the antiproliferative and glycolysis-associated effects of Diclo in MCF-7 breast cancer cells, alone and in combination with docetaxel (Doc) or 5-fluorouracil (5-FU).

Materials and methods: Cell viability was assessed using the sulforhodamine B (SRB) assay. To evaluate metabolic alterations, glucose uptake and lactate release were quantified following treatment. In addition, Triosephosphate Isomerase (TPI) protein levels and Lactate Dehydrogenase (LDH) activity were measured to …

Antiobesity, Antidiabetic, And Antioxidant Activities Of Selected Rubia Species (Rubiaceae) And Lc–Ms/Ms-Based Chemical Profiling ​, Semi̇h Bulut, Ahmet Kahraman, Ayşenur Işik, Mustafa Abdullah Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Rubia species (Rubiaceae) are recognized as medicinal and industrial plants exhibiting diverse biological activities. This study was conducted to evaluate the antioxidant, antidiabetic, and antiobesity potential of extracts prepared from Rubia davisiana Ehrend. (an endemic species), R. peregrina L., and R. rotundifolia Banks & Sol., which grow naturally in Türkiye.

Materials and methods: The antioxidant activity of 80% ethanol extracts prepared from the aerial parts was evaluated using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, ferric reducing power, metal chelating capacity, and total antioxidant capacity assays. Inhibition assays for α-glucosidase and α-amylase were performed to evaluate antidiabetic activity, …

In Re: Lipitor Antitrust Litigation

2026 Decisions

USDC for the District of New Jersey

Posttraumatic Stress In Newly Diagnosed Epilepsy: Associations With Early Maladaptive Schemas, Anxiety, And Quality Of Life In A 6-Month Prospective Study ​, Mehmet Öztürk, Pinar Öztürk, Fügen Sönmez Çeti̇nkaya, İlker Özdemi̇r

Turkish Journal of Medical Sciences

Background/aim: Epilepsy is a chronic neurological disorder that significantly affects psychosocial functioning, self-perception, and quality of life. Emerging evidence suggests that posttraumatic stress (PTS) symptoms may be more prevalent in individuals with epilepsy than previously recognized, particularly following seizure-related experiences perceived as traumatic. The aim of this study was to evaluate short- and long-term PTS levels in individuals with newly diagnosed epilepsy and examine their associations with anxiety, depression, early maladaptive schemas, and quality of life.

Materials and methods: In this prospective study, 31 individuals with newly diagnosed epilepsy were enrolled. Participants completed a sociodemographic data form, the Post-Traumatic Stress …

Long-Term Effects Of Harvesting Disturbance And Site Preparation On Soil Properties And Tree Growth In A Loblolly Pine (Pinus Taeda) Forest, Kyle M. Caccamesi

LSU Master's Theses

Productivity decline between rotations has long been a concern in intensively managed forest plantations. Research done over the last century has provided greater clarity on why this phenomenon occurs. The objective of this research was to observe long-term soil and tree growth characteristics that are likely to be influenced by operational harvesting activities. The experiment was conducted in Washington Parish, Louisiana on a site dominated by Ruston soil series, a well-drained, fine loamy, siliceous and thermic typic Paleudult. A randomized complete block design with 2 x 2 x 2 factorial treatments was used. The treatment factors were harvesting method, fertilization, …

Multi-Ion Permeation And Dynamic Conductance Modulation In Connexin Gap Junction Channels, Bassam G. Haddad, Daniel M. Zuckerman, Steve L. Reichow

Chemistry Faculty Publications and Presentations

Gap junction channels formed by connexins mediate direct intercellular communication and are essential for electrical signaling and tissue homeostasis. Despite their large, solvent-accessible pores, connexin channels exhibit distinct conductance, selectivity, and rectification properties, but the molecular mechanisms underlying these behaviors remain incompletely understood. Here, we performed ~67 μs of all-atom computational electrophysiology simulations of connexin-46 (Cx46), connexin-50 (Cx50), and heterotypic Cx46/50 gap junction channels based on high-resolution open-state structures, enabling characterization of both ion permeation and long-timescale channel dynamics. Simulations reveal a multi-ion, multi-pathway permeation mechanism governed by isoform-specific energetic barriers and transient ion coordination sites that shape conductance and …

The Current - Volume 37 Issue 01, Nova Southeastern University

Student Newspapers

No abstract provided.

Genetic And Mechanistic Dissection Of Missing-Self Killing By Natural Killer Cells, Jeesang Yoon

Arts & Sciences Graduate Student Theses and Dissertations

Natural killer (NK) cells eliminate transformed and infected cells through activating receptor-mediated cytotoxicity and through recognition of cells that have lost major histocompatibility complex class I (MHC-I) expression, a process termed missing-self recognition. Although missing-self recognition is a central principle of NK-cell biology, the mechanisms that execute missing-self killing remain incompletely understood. In this dissertation, we used complementary genetic and functional approaches to investigate the molecular basis of missing-self killing. We first implemented a CRISPR–Cas9 ribonucleoprotein electroporation platform for efficient genetic manipulation of primary murine NK cells, providing a versatile approach for functional studies of NK-cell biology. To identify determinants …

Ancestors And Tiger From Elsewhere: Emerging Forms Of Human-Tiger Socio-Natural Relations In Cosmopolitical Frontiers Of Sumatra, Imam Ardhianto, Febri Sastiviani Putri Cantika, Matahari Jingga, Dimas Iqbal Romadhon

Forest and Society

How are the moral relations between communities and the Sumatran tiger (Panthera tigris sumatrae) being reconfigured as forests fragment and land-use change accelerates across Sumatra's conservation landscape? This article addresses that question ethnographically, drawing on forty semi-structured interviews conducted in Agam and Pasaman Regencies (West Sumatra) between April and June 2026 and interviews with Yayasan SINTAS Indonesia. The article documents the three animistic category of the tiger, comprising Datuk/ancestor, harimau jadi-jadian, and harimau tandang, and traces how it is being reshaped by habitat fragmentation, commodity-driven land expansion, generational interruption of customary authority, and state translocation …

The Freedom Myth: How Ski Culture's Hidden Conformity Reveals The Unconscious Power Of Brand Belonging, Isabel R. Phillips

University Honors Theses

Purpose: Ski culture sells freedom and enforces conformity. This review asks what unconscious behavioral patterns hold that contradiction in place, and how brands capitalize on it to manufacture belonging.

Design/Methodology/Approach: A narrative literature review across consumer psychology, behavioral neuroscience, sociology, and ski industry research. No primary data were collected. Four accounts of consistency-seeking are synthesized into one framework, then applied to three ski industry cases at ascending scales and tested against a comparative case from Spanish football.

Findings: Belonging is a conditioned response, and conditioning requires a stable stimulus. Consistency is therefore the precondition of belonging rather than a constraint …

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

Crispr-Cas9: An Emerging And Precise Genome Editing System For Crops To Combat Food Insecurity, Muhammad Faran Tahi̇r, Muhammad Hamzah Saleem, Sidra Aslam, Emi̇ne Orhan, Hayat Topçu, Tauqeer Ahmed Qadri, Khalid Ali Khan, Muhammad Anas

Turkish Journal of Agriculture and Forestry

Genome editing has emerged as a transformative tool to improve crop productivity, resilience, and nutritional quality, helping address global food insecurity. Among gene-editing platforms, clustered regularly interspaced short palindromic repeats (CRISPR)/ Cas systems (notably CRISPR-Cas9) offer simple, efficient, and scalable methods for targeted modifications, including knockouts, base edits, and precise “search-and-replace” prime edits. In plants, recent advances such as improved base editors, optimized prime-editing platforms, and DNA-free delivery methods have expanded the scope of edits achievable while reducing off-target effects and regulatory concerns. This review summarizes CRISPR principles, highlights technical breakthroughs and crop applications that mitigate biotic and abiotic stresses, …

Cultivar, Canopy Architecture, And Harvest Stage Shape The Chemical Profile Of Plum (Prunus Domestica) Fruit, Jelisaveta Seka Cvijanović, Milica Sredojević, Dragana Dabić Zagorac, Maja Natić, Geza Bujdoso, Miljan Cvetković

Turkish Journal of Agriculture and Forestry

Plum (Prunus domestica L.) is a nutritionally valuable fruit with significant commercial importance, yet consumer acceptance is often constrained by inconsistent fruit quality. This study investigated the effects of cultivar, training system, and harvest stage on the chemical composition of plum fruit, focusing on polyphenols, organic acids, sugars, and sugar alcohols. Three cultivars (Čačanska lepotica, Stanley, and Empress) were evaluated under different canopy architectures, including plum spindle as a control and novel 2-dimensional systems (Bi axe and upright fruiting offshoot), across multiple ripening stages. The results showed that genotype and canopy structure significantly influenced the accumulation of primary and secondary …

A Dosimetric Comparison Of 6-Mv Flattening Filter And Flattening Filter-Free Photon Beams For Stereotactic Body Radiation Therapy Of Adrenal Tumors, Sarah Mcintosh

Masters Projects

Purpose: This study aimed to compare dosimetric characteristics and treatment delivery efficiency between 6-MV Flattening Filter (FF) and Flattening Filter-Free (FFF) photon beams for adrenal Stereotactic Body Radiation Therapy (SBRT). While FFF beams have demonstrated dosimetric and efficiency advantages at other SBRT sites, there is limited data about their use in adrenal SBRT.

Methods and Materials: A retrospective dosimetric comparison was performed using 10 patients previously treated with adrenal SBRT. For each patient, two Volumetric Modulated Arc Therapy (VMAT) plans were generated in Eclipse: one using 6-MV FF beams and one using 6-MV FFF beams, resulting in 20 total treatment …

Topology-Aware Graph Neural Network With Spatiotemporal Encoding And Contrastive Learning For Scalable Dynamic Network Representation, Wassan S. Hayale, Rasha S. Ali, Raghda Abd Ul Rab Abd Ul Hasan, Lateef Abd Zaid Qudr, Safwan Nadwe, Nitin S. Solke, Ravi Sekhar, Pritesh Shah, Reyad Omran Essa

Mesopotamian Journal of Big Data

Recently, Dynamic Graph Neural Networks (DGNNs) have become a potent candidate to model time-changing graphs, although other solutions, including Temporal Graph Networks (TGN), Evolving Graph Convolutional Networks (EvolveGCN), and Dynamic Self-Attention Networks (DySAT), still have significant barriers to scalability, computational efficiency, and temporal embedding drift. To overcome these drawbacks, this paper presents a Topology-Aware Graph Neural Network (TAGNN) model capable of incorporating graph-topology encoding and the spatiotemporal memory mechanisms into the learning process of dynamic node representation. The proposed framework includes three key components: (i) returns global and local structural data such as graph Laplacian-based feature transformations and position encodings, …

Deciphering The Rules Of Odor-Driven Learning In The Fruit Fly Olfactory System, Cole B. Hanan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Odorant identity is encoded by patterns of activity across olfactory receptor neurons (ORNs) and their corresponding glomeruli in the antennal lobe (AL). An odorant's valence can be modified by experience, allowing animals to associate previously neutral odors with appetitive or aversive outcomes. However, some odors appear resistant to such reassignment, and the factors determining whether an odor can acquire learned valence and whether that association generalizes to chemically related odors remain poorly understood. This thesis uses Drosophila melanogaster to address this question using a fully automated proboscis extension reflex (PER) conditioning assay. Odorants are presented via a computer-controlled olfactometer, reward …

A Functional Ultrasound Imaging (Fusi) Pipeline For Investigating Brain-Wide Hemodynamics During Torpor-Like Hypothermia, Owen J. Culver

McKelvey School of Engineering Graduate Student Theses & Dissertations

Torpor is a regulated state of reduced metabolic demand that enables animals to conserve energy under unfavorable environmental conditions. The controlled induction of a similar state, termed synthetic torpor, has potential applications in ischemic protection, organ preservation, cancer treatment, radiation protection, and long-term spaceflight. Although neuronal populations within the preoptic hypothalamus have been shown to initiate hypothermic and hypometabolic states, the distributed cerebral hemodynamic dynamics accompanying their induction and maintenance remain poorly understood. In this thesis, we developed an accessible functional ultrasound imaging (fUSI) acquisition and analysis pipeline and applied it to investigate cerebral hemodynamics during chemogenetic activation of the …