Digital Commons Network^™

Ethical Risks Of Frontier Science And Technology: An Escalating Threat, Xiao Lu, Huihui Liu, Rui Li, Jiaofeng Pan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Science and technology (S&T) are not only powerful tools for development, but also a source of risk. The new round of scientific and technological revolution and industrial transformation are accelerating in current times. It deeply influences and fundamentally reshapes human production and life, which can raise a range of known and unknown ethical risks, involving individual rights and interests, social stability, national security, as well as sustainable development of mankind. This study summarizes the characteristics of ethical risks in frontier S&T, including the dependence on related fields, high uncertainty, social reconstruction, and ultimate challenge. Considering the risks in various fields, …

Optimization For Qinghai-Xizang Plateau Ecological Security Barrier System, Bojie Fu, Yanxu Liu, Wenwu Zhao, Xiaoming Feng, Shiliang Liu, Chiyuan Miao, Xuhui Wang, Chunyang He, Changjia Li, Aizhong Ye, Zhongmin Hu, Zhifeng Liu, Dingyang Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

The ecological security barrier system is a composite system to maintain ecological security and sustainable development within and outside the region. This system enables the maintenance of the structure and function of the ecosystem in the ecological security barrier region relatively shielded from or minimally impacted by external environmental threats, so that forms a multilevel and orderly stable pattern. Over the period from 2000 to 2020, the ecosystem water conservation function was on the rise, and the soil conservation function, net ecosystem productivity, and habitat quality were generally stable in the Qinghai-Xizang Plateau. Comparing the previous three national parks and …

2024-11-20 Flipped Classes Or Flipped Learning?, Dylan Berman

The Spectator Online

No abstract provided.

The Ensemble Code As A Constructed Working Memory, Jacob Zepp

USF Tampa Graduate Theses and Dissertations

This dissertation formalizes and refines a new theory of ensemble coding: the Non-Selective Transfer Model. Within this theory, ensemble codes and subsequent summary judgments are the result of representations constructed over a subset of information that is encoded into working memory. The work begins with a brief review of current ideas present within the ensemble coding literature, followed by a set of formalized descriptions of ensemble coding theories that have been proposed. A discussion of relevant theories present in the working memory literature is also provided to motivate the structure of the subsequent model. The Non-Selective Transfer Model 2 is …

Foundations Of Music Education: Creativity, Curriculum, And Terminal Degrees, Charles Edwin Patterson Iii

USF Tampa Graduate Theses and Dissertations

This collection of articles includes three concepts centered on critical areas within music education: (1) creativity and the creative personality, (2) curriculum development with a focus on orchestral string teaching, and (3) the historical evolution and current status of doctoral programs in music education in the United States. These three articles are correlated through their shared focus on enhancing the field of music education by examining the essential elements that shape practices by students, teachers, mentors, etc. Together, they explore how creativity, curriculum approaches, and advanced training programs in music education contribute to a holistic and adaptive music education framework …

Construction And Evaluation Of A New Rat Reference Genome Assembly, Grcr8, From Long Reads And Long-Range Scaffolding, Kai Li, Melissa L Smith, J Chris Blazier, Kelli J Kochan, Jonathan M D Wood, Kerstin Howe, Anne E Kwitek, Melinda R Dwinell, Hao Chen, Julia L Ciosek, Patrick Masterson, Terence D Murphy, Theodore S Kalbfleisch, Peter A Doris

Faculty, Staff and Student Publications

We report the construction and analysis of a new reference genome assembly for Rattus norvegicus, the laboratory rat, a widely used experimental animal model organism. The assembly has been adopted as the rat reference assembly by the Genome Reference Consortium and is named GRCr8. The assembly has employed 40× Pacific Biosciences (PacBio) HiFi sequencing coverage and scaffolding using optical mapping and Hi-C. We used genomic DNA from a male BN/NHsdMcwi (BN) rat of the same strain and from the same colony as the prior reference assembly, mRatBN7.2. The assembly is at chromosome level with 98.7% of the sequence assigned …

Phase I Dose Escalation Study Of Io-108, An Anti-Lilrb2 Antibody, In Patients With Advanced Solid Tumors, Matthew H Taylor, Aung Naing, John Powderly, Paul Woodard, Luke Chung, Wen Hong Lin, Hongyu Tian, Nathan Siemers, Hong Xiang, Rong Deng, Kyu Hong, Donna Valencia, Tao Huang, Ying Zhu, X Charlene Liao, Xiao Min Schebye, Manish R Patel

Faculty, Staff and Student Publications

Purpose: In this first-in-human dose escalation study, the safety and efficacy of IO-108, a fully human monoclonal antibody targeting leukocyte immunoglobulin-like receptor B2 (LILRB2), was investigated in patients with advanced solid tumors as monotherapy and in combination with pembrolizumab, an anti-programmed cell death protein 1 (PD-1) antibody.

Methods: The study included patients with histologically or cytologically confirmed advanced and relapsed solid tumors, with measurable disease by Response Evaluation Criteria In Solid Tumors (RECIST) V.1.1. Patients were treated with escalating doses of IO-108 every 3 weeks (Q3W) as monotherapy and in combination with pembrolizumab. Safety and tolerability were the primary objectives. …

Cladribine-Based Therapy For Acute Myeloid Leukemia In Child, Adolescent, And Early Young Adult Patients: The Md Anderson Cancer Center Experience, David Mccall, Shaikha Alqahtani, Moriah Budak, Irtiza Sheikh, Aaron E Fan, Ramya Ramakrishnan, Cesar Nunez, Michael Roth, Miriam B Garcia, Amber Gibson, Naval Daver, Sofia Garces, Nicholas J Short, Ghayas C Issa, Farhad Ravandi, Courtney D Dinardo, Guillermo Montalban Bravo, Guillermo Garcia-Manero, Branko Cuglievan, Tapan Kadia

Faculty, Staff and Student Publications

Background: Cladribine-based combination chemotherapy has demonstrated promising efficacy in patients with relapsed/refractory adult acute myeloid leukemia (AML), prompting its increased utilization in the frontline; in pediatrics, it has been typically reserved for relapsed or refractory cases. While fludarabine has been used more commonly as a purine analog in intensive regimens, cladribine may be an important alternative.

Methods: We performed a retrospective study at MD Anderson Cancer Center from January 2015 to July 2023, which included patients aged 1-21 years with refractory or relapsed AML who received cladribine outside of a transplant conditioning.

Results: A total of 30 patients were included, …

Mean Field Control Of Droplet Dynamics With High-Order Finite-Element Computations, Guosheng Fu, Hangjie Ji, Will Pazner, Wuchen Li

Mathematics and Statistics Faculty Publications and Presentations

Liquid droplet dynamics are widely used in biological and engineering applications, which contain complex interfacial instabilities and pattern formation such as droplet merging, splitting, and transport. This paper studies a class of mean field control formulations for these droplet dynamics, which can be used to control and manipulate droplets in applications. We first formulate the droplet dynamics as gradient flows of free energies in modified optimal transport metrics with nonlinear mobilities. We then design an optimal control problem for these gradient flows. As an example, a lubrication equation for a thin volatile liquid film laden with an active suspension is …

Multi-Generational Dispersal And Dynamic Patch Occupancy Reveals Spatial And Temporal Stability Of Seascapes, Charlotte Clubley, Tiago A M Silva, Louisa E Wood, Louise Firth, David T Bilton, Edna O'Dea, Antony Knights

School of Biological and Marine Sciences

The success of non-native species (NNS) invasions depends on patterns of dispersal and connectivity, which underpin genetic diversity, population establishment and growth. In the marine environment, both global environmental change and increasing anthropogenic activity can alter hydrodynamic patterns, leading to significant inter-annual variability in dispersal pathways. Despite this, multi-generational dispersal is rarely explicitly considered in attempts to understand NNS spread or in the design of management interventions. Here, we present a novel approach to quantifying species spread that considers range expansion and network formation across time using the non-native Pacific oyster, Magallana gigas (Thunberg 1793), as a model. We combined …

Can Eggshells Indicate Stressor Exposure In Free-Range Laying Hens?, Helen E. Gray, Emma L. Malcolm, Katherine Herborn, David Armstrong, Jessica E. Martin, Lucy Asher

School of Biological and Marine Sciences

Finding effective ways to monitor laying hen welfare is challenging as UK flock sizes can reach 16,000 birds. Eggs provide potential for welfare monitoring, as they are a daily output with previous evidence of links to stress. We explored the associations between stressors and eggs using two complementary studies. In Study 1, hens experienced social or heat stressors and eggs were scored daily for defects in shell characteristics. All eggs were scored on a three-point scale: 1 (no defect); 2 (minor defects); or 3 (unsuitable for whole egg sale in the UK). Texture defects were higher after stress treatments and …

Predictors Of Long-Term Variability In Ne Atlantic Plankton Communities, Matthew M. Holland, Angus Atkinson, Mike Best, Eileen Bresnan, Michelle Devlin, Eric Goberville, Pierre Hélaouët, Margarita Machairopoulou, Matthew Faith, Murray S.A. Thompson, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

Anthropogenic pressures such as climate change and nutrient pollution are causing rapid changes in the marine environment. The relative influence of drivers of change on the plankton community remains uncertain, and this uncertainty is limiting our understanding of sustainable levels of human pressures. Plankton are the primary energy resource in marine food webs and respond rapidly to environmental changes, representing useful indicators of shifts in ecosystem structure and function. Categorising plankton into broad groups with similar characteristics, known as “lifeforms”, can be useful for understanding ecological patterns related to environmental change and for assessing the state of pelagic habitats in …

Leveraging The T2t Assembly To Resolve Rare And Pathogenic Inversions In Reference Genome Gaps, Kristine Bilgrav Saether, Jesper Eisfeldt, Jesse D Bengtsson, Ming Yin Lun, Christopher M Grochowski, Medhat Mahmoud, Hsiao-Tuan Chao, Jill A Rosenfeld, Pengfei Liu, Marlene Ek, Jakob Schuy, Adam Ameur, Hongzheng Dai, Undiagnosed Diseases Network, James Paul Hwang, Fritz J Sedlazeck, Weimin Bi, Ronit Marom, Josephine Wincent, Ann Nordgren, Claudia M B Carvalho, Anna Lindstrand

Faculty, Staff and Students Publications

Chromosomal inversions (INVs) are particularly challenging to detect due to their copy-number neutral state and association with repetitive regions. Inversions represent about 1/20 of all balanced structural chromosome aberrations and can lead to disease by gene disruption or altering regulatory regions of dosage-sensitive genes in cis. Short-read genome sequencing (srGS) can only resolve ∼70% of cytogenetically visible inversions referred to clinical diagnostic laboratories, likely due to breakpoints in repetitive regions. Here, we study 12 inversions by long-read genome sequencing (lrGS) (n = 9) or srGS (n = 3) and resolve nine of them. In four cases, the …

High-Coverage Nanopore Sequencing Of Samples From The 1000 Genomes Project To Build A Comprehensive Catalog Of Human Genetic Variation, Jonas A Gustafson, Sophia B Gibson, Nikhita Damaraju, Miranda P G Zalusky, Kendra Hoekzema, David Twesigomwe, Lei Yang, Anthony A Snead, Phillip A Richmond, Wouter De Coster, Nathan D Olson, Andrea Guarracino, Qiuhui Li, Angela L Miller, Joy Goffena, Zachary B Anderson, Sophie H R Storz, Sydney A Ward, Maisha Sinha, Claudia Gonzaga-Jauregui, Wayne E Clarke, Anna O Basile, André Corvelo, Catherine Reeves, Adrienne Helland, Rajeeva Lochan Musunuri, Mahler Revsine, Karynne E Patterson, Cate R Paschal, Christina Zakarian, Sara Goodwin, Tanner D Jensen, Esther Robb, 1000 Genomes Ont Sequencing Consortium, University Of Washington Center For Rare Disease Research (Uw-Crdr), Genomics Research To Elucidate The Genetics Of Rare Diseases (Gregor) Consortium, William Richard Mccombie, Fritz J Sedlazeck, Justin M Zook, Stephen B Montgomery, Erik Garrison, Mikhail Kolmogorov, Michael C Schatz, Richard N Mclaughlin, Harriet Dashnow, Michael C Zody, Matt Loose, Miten Jain, Evan E Eichler, Danny E Miller

Faculty, Staff and Students Publications

Fewer than half of individuals with a suspected Mendelian or monogenic condition receive a precise molecular diagnosis after comprehensive clinical genetic testing. Improvements in data quality and costs have heightened interest in using long-read sequencing (LRS) to streamline clinical genomic testing, but the absence of control data sets for variant filtering and prioritization has made tertiary analysis of LRS data challenging. To address this, the 1000 Genomes Project (1KGP) Oxford Nanopore Technologies Sequencing Consortium aims to generate LRS data from at least 800 of the 1KGP samples. Our goal is to use LRS to identify a broader spectrum of variation …

Evolution Of International Collaboration In China’S Biomedical Technology And Policy Implications, Xinyu Liu, Fang Wang, Liang Xi

Bulletin of Chinese Academy of Sciences (Chinese Version)

In light of the rapid advancement of biomedical technologies and intensifying geopolitical competition over technological dominance, international cooperation in this field has garnered significant attention among scholars, policymakers, and industry leaders. This study employs comprehensive patent data spanning from 2002 to 2023 across the global biomedical landscape to systematically investigate the characteristics and evolution patterns of both global and Chinese biomedical inventions. Employing econometric analysis of patents and social network analysis, the research examines three key dimensions: patent output, technological pathways, and collaboration networks. Three research findings are derived. Firstly, China has transitioned from a “catch-up collaborator” to a critical …

Gmc-4190 Cellnucleirag - Smart Search Tool For Cell Nuclei Research, Sai Chandana Koganti

C-Day Computing Showcase

CellNucleiRAG is a specialized tool developed to address a significant challenge in medical research: the rapid retrieval and synthesis of detailed information on cell nuclei. Understanding cell nuclei characteristics is crucial in fields like pathology, oncology, and diagnostics, where detailed cell analysis can guide disease identification and treatment planning. However, accessing relevant, organized information on specific cell nuclei types, datasets, models, and methods is often time-consuming, requiring manual searches through multiple, disparate sources. CellNucleiRAG solves this problem by acting as a smart search engine, designed specifically for cell nuclei research, combining traditional retrieval methods with advanced AI capabilities. Built with …

Uc-133 Biomedical Deep Learning - A Staged Approach Using Trustworthy Deep Learning For Multi-Omics Data Classification, Yongbo An, Tianze Liu

C-Day Computing Showcase

Genetic data such as mRNA, miRNA, and DNA methylation offer precious insights into the underlying causes variant diseases. These types of data provide various layers of information, simultaneously enhancing our understanding of the disease and improving diagnostic accuracy. Combining mRNA, miRNA, and DNA methylation data allows for a multi-dimensional approach to identifying biomarkers, potentially leading to earlier and more accurate diagnosis. However, integrating all modalities is not practical. The clinical cost increases significantly with every modality incorporated. In contrast to previous methods, our model uses partial modalities when possible. We will use subjective logic and trustworthy deep learning under the …

Ritualized Engrossment: Portraits Of Early-Career Faculty Practicing Renewal, Samantha Goss, Libba Willcox

International Journal of Lifelong Learning in Art Education

In higher education, the demands on early-career faculty often lead to mental health challenges and time poverty. This article explores two major issues that negatively impact faculty well-being: the disconnect between doctoral socialization and tenure-track realities, and the struggle to balance unrealistic expectations with sustainable practices. To address the dissonance we felt as early career faculty, we developed a renewal practice called ritualized engrossment, characterized by connection, collaboration, care, and commitment. Grounded in aesthetic approaches and using methods from portraiture and collaborative autoethnography, we present two narrative portraits illustrating the impact of this practice on our well-being. Our portraits illustrate …

Sex Education Policy Compared In Denmark And The United States

The Dialogue

Mary Katherine Shoemaker and Kathleen Strauss compare sex education policies in Denmark and the U.S., focusing on their impact on teenage birth rates. The paper highlights Denmark's comprehensive education model, which contrasts with abstinence-focused programs prevalent in the U.S., and discusses how these differences contribute to disparities in teenage pregnancy rates

Rizal And Science: A Struggle For Faith, Reason, And Knowledge, Michael L. Tan

Budhi: A Journal of Ideas and Culture

Much of what has been written about Jose Rizal focuses on his political thinking, with side references to his numerous accomplishments in the arts and letters, in science, technology, and medicine. in this essay, i choose to focus on Rizal the scientist, both in the sense of someone searching for knowledge as well as someone employing scientific methods to the study of society. i use Rizal’s writings, including correspondence with family and friends and a former Jesuit mentor, Father Pablo Pastells; his “letter to the Women of Malolos”; his essay “indolence of the Filipinos”; and his novel Noli Me Tangere …

An Unusual Histopathological Presentation Of Mandibular Osteosarcoma, *Saja A. Alramadhan, Rutvi Vyas, Indraneel Bhattacharyya, Mohammed N. Islam, John D. Reith

Oral-Maxillofacial Surgery and Pathology Publications

Jaw osteosarcoma (JOS) is a rare, distinct variant that differ from long bone osteosarcoma (LBOS) in several aspects. JOS typically appears about twenty years later than LBOS, displays a lower propensity for metastasis to other organs, and exhibits better survival rates. The dissimilarities in clinical and biological behavior between JOS and LBOS are likely due, at least in part, to variations in their respective microenvironments. In this report, we present a case of OS affecting the mandible in a young patient. This case displayed classic radiographic features but a unique histopathological presentation, posing a diagnostic challenge for pathologists, especially if …

University Libraries Advances Campus Partnerships, Lisa Deluca

SHU Libraries News

No abstract provided.

The Effects Of Covid-19 On Parenting, Nicole S. Berger

ETD Collection

This study examined effects of the COVID-19 pandemic on parenting behaviors. Parent Development Theory (PDT) (Mowder, 2005) suggests the greater social-cultural environment can influence how parents perceive their role in relation to their child. The PDT parenting behaviors can be conceptualized as bonding, discipline, education, general welfare and protection, responsivity, sensitivity and negativity (Mowder, 2018). Changes in society during the pandemic may have influenced parenting behaviors and overall family dynamics. To address this question, participants completed demographic questions, the Parent Behavior Importance Questionnaire–3 (PBIQ–3) (Mowder, 2018), and an open-ended survey. Results from the PBIQ–3 were compared to previously collected parent …

E.Pathdash, Pathway Activation Analysis Of Publicly Available Pathogen Gene Expression Data., Lily Taub, Thomas H Hampton, Sharanya Sarkar, Georgia Doing, Samuel L Neff, Carson E Finger, Kiyoshi Ferreira Fukutani, Bruce A Stanton

Faculty Research 2024

UNLABELLED: E.PathDash facilitates re-analysis of gene expression data from pathogens clinically relevant to chronic respiratory diseases, including a total of 48 studies, 548 samples, and 404 unique treatment comparisons. The application enables users to assess broad biological stress responses at the KEGG pathway or gene ontology level and also provides data for individual genes. E.PathDash reduces the time required to gain access to data from multiple hours per data set to seconds. Users can download high-quality images such as volcano plots and boxplots, differential gene expression results, and raw count data, making it fully interoperable with other tools. Importantly, users …

Uab Biologist To Co-Lead A Five-Year Nih Grant To Investigate Social Impacts On Lifespan, Staff

Browse All News

No abstract provided.

Compositions And Methods Relating To Novel Sulfono-Gamma-Aa Peptides, Chuanhai Cao, Jianfeng Cai

USF Patents

Provided herein are compounds, compositions, pharmaceutical compositions, kits, and methods relating to novel sulfono-γ-AA peptides. Novel sulfono-γ-AA peptides as described herein can have the structure according to Formula 1: In embodiments according to the present disclosure, novel sulfono-γ-AA peptides as described herein have minimal toxicity, can repair neuronal damage, inhibit Amyloid beta aggregation, and promote cellular growth and viability.

Systems And Methods For Classifying Mosquitoes Based On Extracted Masks Of Anatomical Components From Images, Sriram Chellappan, Mona Minakshi, Pratool Bharti, Ryan M Carney

USF Patents

Images of an insect are subjected to at least a first convolutional neural network to develop feature maps based on anatomical pixels at corresponding image locations in the respective feature maps. The anatomical pixels correspond to a body part of the insect. A computer calculates an outer product of the first feature map and the second feature map to form an integrated feature map. Extracting fully connected layers from respective sets of integrated feature maps and applying the fully connected layers to a classification network for identifying the genus and the species of the insect.

Computing 2-Body Statistics On Graphics Processing Units (Gpus), Yicheng Tu, Napath Pitaksirianan

USF Patents

Disclosed are various embodiments for computing 2-body statistics on graphics processing units (GPUs). Various types of two-body statistics (2-BS) are regarded as essential components of data analysis in many scientific and computing domains. However, the quadratic complexity of these computations hinders timely processing of data. According, various embodiments of the present disclosure involve parallel algorithms for 2-BS computation on Graphics Processing Units (GPUs). Although the typical 2-BS problems can be summarized into a straightforward parallel computing pattern, traditional wisdom from (general) parallel computing often falls short in delivering the best possible performance. Therefore, various embodiments of the present disclosure involve …

Methods For Sampling Into An Atmospheric Pressure Inlet Mass Spectrometer, Theresa Evans-Nguyen, Linxia Song, Yi You

USF Patents

Provided herein are systems and methods for sampling analytes into an atmospheric pressure inlet mass spectrometer using ultrasonic nebulization-assisted atmospheric pressure chemical ionization. The systems can include a mass spectrometer having an input and an ultrasonic nebulizer chip. The ultrasonic nebulizer chip can be operatively coupled to the mass spectrometer, such that when the ultrasonic nebulizer chip nebulizes the analyte to provide a nebulized analyte, at least some of the nebulized analyte enters the input of the mass spectrometer.

Plasma Derived From Human Umbilical Cord Blood For The Treatment Of Neurodegenerative Disorders, Svitlana Garbuzova-Davis, Jared Carl Ehrhart, Paul R. Sanberg

USF Patents

A method of treating neurodegenerative diseases using hUCB plasma is presented herein. hUCB plasma attenuated the hyperactive response (Group III) and potentiated the normal response in Group I ALS patients, but did not alter that of the non-responders to PHA (Group II). The elevated activity of caspase 3/7 observed in the MNCs from ALS patients was significantly reduced by hUCB plasma treatment. The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggest that the use of hUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients. hUCB plasma …