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Advancements In Autophagy Modulation For The Management Of Oral Disease: A Focus On Drug Targets And Therapeutics, Md Ataur Rahman, Mushfiq Hassan Shaikh, Rajat Das Gupta, Nazeeba Siddika, Muhammad Saad Shaikh, Muhammad Sohail Zafar, Bonglee Kim, Ehsanul Hoque Apu

School of Medicine Publications

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, and thereby cell survival. Oral health is an essential component of integrated well-being, and it is critical for developing therapeutic interventions to understand the molecular mechanisms underlying the maintenance of oral homeostasis. However, because of the complex dynamic relationship between autophagy and oral health, associated treatment modalities have not yet been well elucidated. Determining how autophagy affects oral health at the molecular level may enhance the understanding of prevention and treatment of targeted oral diseases. At the molecular level, hard and soft oral tissues …

Jaha At Scientific Sessions 2023: Moving Toward Social Justice In Cardiovascular Health In The United States, Carissa M. Baker-Smith, Salina P. Waddy, Sara Hassani, Mahasin Mujahid, Tochi Okwuosa, Emmanuel Peprah, Bernadette Boden-Albala

Department of Medicine Faculty Papers

Attention to social justice is essential to improving cardiovascular health outcomes. In the absence of social justice, equitable cardiovascular health is impossible. This viewpoint provides a brief synopsis of the 2023 Journal of the American Heart Association (JAHA)–sponsored session titled “Moving Towards Social Justice in Cardiovascular Health.” We define social justice and summarize the burden of cardiovascular disease inequity in the United States. We also highlight strategies for achieving social justice, including addressing workforce diversity, integrating social determinants into cardiovascular research, designing cardiovascular interventions to close the equity gap, and improving inclusivity in cardiovascular disease trials.

Il-37 Suppresses Cns Autoimmunity By Increasing The Frequency Of Treg Cells And Reducing Cd4 + T Cell-Derived Il-10 Production, Reza Yazdani, Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Mozhde Askari, Amir Moghadam-Ahmadi, Jaya Aseervatham, Guang-Xian Zhang, Mohamad Rostami

Department of Neurology Faculty Papers

BACKGROUND: Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased serum levels of IL-37. However, it is unknown whether IL-37 has an inhibitory effect on ongoing autoimmune neuroinflammation, thus offering a potential MS therapy.

AIM: Here, we examined the effect of IL-37 in an experimental autoimmune encephalomyelitis (EAE) model after disease onset to determine if it was protective.

FINDINGS: IL-37-treated mice developed a less severe disease than control mice, with reduced demyelination as determined by increased expression of myelin basic protein. …

Predicting Severe Covid-19 Using Readily Available Admission Indicators: Spo2/Fio2 Ratio, Comorbidity Index, And Gender, Luan D. Vu, Rebecca C. Christofferson, Hollis R. O’Neal, Diana Hamer, Anh T.Q. Phan, Katie M. Vance, E. A. Turner, Avinash Kumar, Ibrahim Musa Yola, Natalie Lim, Beverly Ogden, Stephania A. Cormier

School of Medicine Faculty Publications

The focus of this study was to identify risk factors for severe and critical COVID-19, evaluate local respiratory immune responses to SARS-CoV-2 infection, and develop a prognostic tool for COVID-19 severity using accessible early indicators. Using nasopharyngeal swab samples from hospitalized patients with COVID-19 of varying severity during the first wave of the pandemic from March to May 2020 in Louisiana, we evaluated the association between COVID-19 severity and viral load, respiratory immune mediators, and demographic/clinical factors. We found that the SpO2/FiO2 ratio at triage, total comorbidity burden (represented by Charlson Comorbidity Index), and gender were significantly associated with COVID-19 …

Cas Connections- 2024 Fall Term - November, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.

Factors That Influence Colostrum Yield: Environmental Temperature And Photoperiod, Peter S. Erickson

UNH Cooperative Extension

No abstract provided.

Human Studies Of The Efficacy And Safety Of Stem Cells In The Treatment Of Diabetic Peripheral Neuropathy: A Systematic Review And Meta-Analysis, Seyed Danial Alizadeh, Shima Jahani, Mohammad Rezaei Zadeh Rukerd, Reza Tabrizi, Rasoul Masoomi, Seyedeh Zahra Banihashemian, Mahgol Sadat Hassan Zadeh Tabatabaei, Zahra Ghodsi, Ahmad Pour-Rashidi, James Harrop, Vafa Rahimi-Movaghar

Department of Neurosurgery Faculty Papers

OBJECTIVE: To assess the efficacy and safety of stem cell therapy in human studies for diabetic peripheral neuropathy (DPN).

METHODS: A comprehensive literature review was performed across multiple databases, including Ovid MEDLINE ALL, Embase via Ovid SP, Scopus, Web of Science Core Collection, and Cochrane CENTRAL, up to January 31, 2024. Keywords and controlled vocabularies related to diabetic neuropathy and stem cell therapy were used. Inclusion criteria encompassed all controlled trials examining stem cell therapy for DPN, excluding animal or in vitro studies, review papers, conference abstracts, and editor letters. Data extraction and risk of bias assessment were independently performed …

Initial Reactions: Rethinking The Efficacy Of Current Contractual Practies For Consumer Protection, Sarah E. Wellard

College of Science and Health Theses and Dissertations

To protect consumers from unfair contracts, legislatures have implemented measures requiring consumers to signal specific agreement to crucial clauses. One such common practice is requiring consumers to initial specific provisions within contracts. This dissertation investigates the efficacy of initialing and other secondary tasks in promoting consumer understanding and memory of contractual information. Through a series of three experimental studies, participants engaged in tasks involving initialing, semantic processing, or irrelevant letter-classification tasks while processing contract information. Contrary to predictions, the findings failed to show that initialing or other secondary tasks significantly improved consumer’s reported memory or understanding of contract terms, compared …

Adjuvant Radiation Therapy In Desmoplastic Melanoma: A Scoping Review, Christina Setareh Sharafi, B Ashleigh Guadagnolo, Kelly C Nelson, Devarati Mitra

Faculty, Staff and Student Publications

Desmoplastic melanoma (DM) is an uncommon subtype of cutaneous melanoma that presents distinct diagnostic and treatment challenges. This review aims to explore the role of adjuvant radiation therapy (RT) in managing DM. To evaluate this question, we reviewed relevant published reports on DM and its treatment and synthesized these findings. It was found that the clinical behavior of DM varies significantly based on its classification as either "pure" DM (pDM, ≥90% desmoplastic features) or mixed DM (mDM, ≤90% desmoplastic features). Patients with pDM have a uniquely high risk of local recurrence but a relatively lower likelihood of nodal disease. Recent …

The George-Anne, Georgia Southern University

The George-Anne

• Donald Trump Wins 2024 Presidential Race
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• Hidden Gems: The Flowergirl
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• GS Current Athletic Director Accepts New Position at Auburn, New Athletic Director Announced
• Armstrong students react to Trump's return to office
• Armstrong's Fang-tastic Halloween Costumes
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• Armstrong Knows How to Celebrate
• The Artsy Girl

Can The Effluent From Wastewater Stabilization Ponds Be Effectively Managed For Health And Nutrient Recovery?, Michael Glass

USF Tampa Graduate Theses and Dissertations

Wastewater stabilization ponds, such as facultative and maturation lagoons, have been shown to be effective processes to manage conventional water quality parameters found in domestic wastewater. The main goal of this thesis is to explore whether wastewater stabilization ponds can simultaneously reduce pathogens to safe levels while supporting agricultural activities through nutrient recovery. A large dataset for water quality of wastewater lagoon effluent in the U.S. was obtained at the state level and combined into regional southern and northern locations. Analysis of data showed there was significant difference in lagoon effluent concentration between northern and southern states for the water …

Beyond The Mask: Veterans Challenging The Strong Black Woman Trope In Their Journey To Heal In The South, Meya J. Hemphill-Hodges

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation is to emphasize notions of citizenship and accessibility as experienced by Black women Veterans. By expanding our worldview of Veteran identity, the ethnographic data demonstrate issues of displacement, alienation, and longing that contribute to the dissonance Black women Veterans rooted in the U.S. South may experience. To forge belonging through place-making, Black women Veterans may seek sisterhood by building sites of resistance in person or online. Findings are based on in-depth interviews with Black women Veterans and participant observation with community partners who service Veteran needs. Black women Veterans construct their identities often in oppressive …

Delta-Like Ligand 3 (Dll3) Landscape In Pulmonary And Extra-Pulmonary Neuroendocrine Neoplasms, Alejandra G Serrano, Pedro Rocha, Cibelle Freitas Lima, Allison Stewart, Bingnan Zhang, Lixia Diao, Junya Fujimoto, Robert J Cardnell, Wei Lu, Khaja Khan, Beate Sable, Aaron R Ellison, Ignacio I Wistuba, Kyle F Concannon, Daniel M Halperin, Czerniak Bogdan, Kanishka Sircar, Miao Zhang, Kasey Cargill, Qi Wang, Ana Aparicio, Alexander Lazar, Sharia Hernandez, Jeannelyn Estrella, Preetha Ramalingam, Adel El-Naggar, Neda Kalhor, Carl M Gay, Lauren Averett Byers, Luisa M Solis Soto

Faculty, Staff and Student Publications

Delta-like Ligand 3 (DLL3) targeting therapies are promising in small cell lung cancer (SCLC) treatment. However, DLL3 expression in SCLC and other neuroendocrine neoplasms (NEN) is heterogeneous and not well characterized. We describe the landscape of DLL3 at the mRNA and protein levels across SCLC, large cell neuroendocrine carcinoma (LCNEC), and non-small cell lung cancer. Additionally, we explore its expression in extra-pulmonary NEN (EP-NEN) using a standardized DLL3 IHC assay. DLL3 expression is enriched in SCLC, LCNEC along with combined histology lung cancers. Moreover, we find a wide range of DLL3 expression in high-grade EP-NEN. We describe heterogenous DLL3 expression …

The Recreational Value Of Birding And Crane Abundance, Richard T. Melstrom, Alex Nielsen, Carson Reeling

Department of Agricultural Economics Faculty Publications

We estimate the economic value of birding, which is an important ecosystem service produced by bird populations in recreation areas. Our research identifies the link between values and species richness as well as the abundance of the sandhill crane (Grus canadensis), which migrates each year through our study area. Sandhill crane stopovers at state and federal wildlife areas can attract many birders. We estimate this nonmarket value using the zonal travel cost method and data from the eBird project on wildlife areas in Indiana. We compare crane counts based on eBird with those from the Indiana Department of Natural Resources …

Prevalent Atherosclerotic Cardiovascular Disease Among Veterans By Sexual Orientation, Carl G. Streed, Meredith S. Duncan, Kory R. Heier, T. Elizabeth Workman, Lauren B. Beach, Billy A. Caceres, John R. O’Leary, Melissa Skanderson, Joseph L. Goulet

Biostatistics Faculty Publications

BACKGROUND: Seven million lesbian, gay, and bisexual (LGB) adults will be aged >50 years by 2030; assessing and addressing their risk for cardiovascular disease is critical. METHODS AND RESULTS: We analyzed a nationwide cohort using the Veterans Health Administration data. Sexual orientation (SO) was classified via a validated natural language processing algorithm. Prevalent atherosclerotic cardiovascular disease (ASCVD) (history of acute myocardial infarction, ischemic stroke, or revascularization) was identified via International Classification of Diseases, Ninth and Tenth Revision (ICD-9 and ICD-10) codes. The index date was the date of the first primary care appointment on or after October 1, 2009. We …

Are Biobased Microfibers Less Harmful Than Conventional Plastic Microfibers: Evidence From Earthworms, W. Courtene-Jones, F. De Falco, F. Burgevin, R. D. Handy, R. C. Thompson

School of Geography, Earth and Environmental Sciences

Biobased plastics are sometimes promoted as “environmentally friendly” compared to their conventional petrochemical-based counterparts, but their ecotoxicity is only partially understood. Biobased fibers are widely used in clothing and wet wipes and can accumulate in soils through the application of biosolid fertilizers. This study examined the lethal thresholds and sublethal toxicity of chemically characterized, additive-free, biobased (viscose and lyocell) compared to petrochemical-based (polyester) fibers on the key ecosystem engineer, Esenia fetida. Viscose and lyocell had LC₂₀ values of 14.00 and 22.66 mg·L^-1, respectively, and no observed effect concentrations (NOEC) of 0-2.8 mg·L^-1 (72 h, OECD TG207 …

Factors That Influence Colostrum Yield: Hormones, Peter S. Erickson

UNH Cooperative Extension

No abstract provided.

Factors Affecting Colostrum Yield: Mastitis, Calf Size, And Udder Size, Peter S. Erickson

UNH Cooperative Extension

No abstract provided.

Things To Do When A Calf Is Born, Peter S. Erickson

UNH Cooperative Extension

No abstract provided.

Network-Based Biomarkers In Background Electroencephalography In Childhood Epilepsies – A Scoping Review And Narrative Synthesis, Rohit Shankar, John Terry

Peninsula Medical School

BackgroundBrain network analysis is an emerging field of research that could lead to the development, testing and validation of novel biomarkers for epilepsy. This could shorten the diagnostic uncertainty period, improve treatment, decrease seizure risk and lead to better management. This scoping review summarises the current state of electroencephalogram (EEG)-based network abnormalities for childhood epilepsies. The review assesses the overall robustness, potential generalisability, strengths, and limitations of the methodological frameworks of the identified research studies.Reporting MethodsPRISMA guidelines for Scoping Reviews and the PICO framework was used to guide this review. Studies that evaluated candidate network-based features from EEG in children …

What Influences Women's Participation In The Private Sector Workforce In Oman?, Rakesh Belwal, Shweta Belwal, Suhaila Alhashemi

Plymouth Business School

Purpose: Women’s employment has been a contentious issue in the Arab world. However, in today’s changing work conditions, workplaces, and the growth in education, women have increasingly occupied higher-level roles, and their presence in diverse industries has expanded. The study takes a holistic approach to female labor force participation (FLFP) in Oman, encompassing various theories and factors influencing women’s engagement in private sector jobs. Design/methodology/approach: The research employed an exploratory design followed by a qualitative analysis based on a constructivist grounded theory approach. The study involved 170 semi-structured face-to-face interviews with women workers in Oman’s private sector. It explored work–family …

Strategies To Alleviate Flickering: Bayesian And Smoothing Methods For Deep Learning Classification In Video, Noah Miller, Glen Ryan Drumm, Lance Champagne, Bruce A. Cox, Trevor Bihl

Faculty Publications

Excerpt: Increasing reliance on autonomous systems requires confidence in the accuracies produced from computer vision classification algorithms. Computer vision (CV) for video classification provides phenomenal abilities, but it often suffers from “flickering” of results. Flickering occurs when the CV algorithm switches between declared classes over successive frames. Such behavior causes a loss of trust and confidence in their operations.

Disordered Proteins Interact With The Chemical Environment To Tune Their Protective Function During Drying, Shraddha Kc, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Paulette Sofia Romero-Perez, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby

2020-Current year OA Pubs

The conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins, combined with the exposure of their residues, accounts for this sensitivity. One context in which IDPs play important roles that are concomitant with massive changes to the intracellular environment is during desiccation (extreme drying). The ability of organisms to survive desiccation has long been linked to the accumulation of high levels of cosolutes such as trehalose or sucrose as well as the enrichment of IDPs, such as late embryogenesis abundant (LEA) proteins or cytoplasmic abundant heat-soluble (CAHS) proteins. …

Discovery Of Highly Potent And Alk2/Alk1 Selective Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Ravikumar Jimmidi, Diana Monsivais, Hai Minh Ta, Kiran L Sharma, Kurt M Bohren, Srinivas Chamakuri, Zian Liao, Feng Li, John M Hakenjos, Jian-Yuan Li, Yuji Mishina, Haichun Pan, Xuan Qin, Matthew B Robers, Banumathi Sankaran, Zhi Tan, Suni Tang, Yasmin M Vasquez, Jennifer Wilkinson, Damian W Young, Stephen S Palmer, Kevin R Mackenzie, Choel Kim, Martin M Matzuk

Faculty, Staff and Students Publications

Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate extracellular signals of bone morphogenic proteins (BMPs) and activins into Mothers Against Decapentaplegic homolog 1/5 (SMAD1/SMAD5) signaling complexes. Several activating mutations in ALK2 are implicated in fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine gliomas, and ependymomas. The ALK2 R206H mutation is also present in a subset of endometrial tumors, melanomas, non–small lung cancers, and colorectal cancers, and ALK2 expression is elevated in pancreatic cancer. Using DNA-encoded chemistry technology, we screened 3.94 billion unique compounds from our diverse …

Discovery Of Highly Potent And Alk2/Alk1 Selective Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Ravikumar Jimmidi, Diana Monsivais, Hai Minh Ta, Kiran L Sharma, Kurt M Bohren, Srinivas Chamakuri, Zian Liao, Feng Li, John M Hakenjos, Jian-Yuan Li, Yuji Mishina, Haichun Pan, Xuan Qin, Matthew B Robers, Banumathi Sankaran, Zhi Tan, Suni Tang, Yasmin M Vasquez, Jennifer Wilkinson, Damian W Young, Stephen S Palmer, Kevin R Mackenzie, Choel Kim, Martin M Matzuk

Faculty, Staff and Students Publications

Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate extracellular signals of bone morphogenic proteins (BMPs) and activins into Mothers Against Decapentaplegic homolog 1/5 (SMAD1/SMAD5) signaling complexes. Several activating mutations in ALK2 are implicated in fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine gliomas, and ependymomas. The ALK2 R206H mutation is also present in a subset of endometrial tumors, melanomas, non-small lung cancers, and colorectal cancers, and ALK2 expression is elevated in pancreatic cancer. Using DNA-encoded chemistry technology, we screened 3.94 billion unique compounds from our diverse …

Sound Innovations For Biofabrication And Tissue Engineering, Mengxi Wu, Zhiteng Ma, Zhenhua Tian, Joseph Rich, Xin He, Jianping Xia, Ye He, Kaichun Yang, Shujie Yang, Kam W. Leong, Luke P. Lee, Tony Jun Huang

Faculty Publications

Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional (3D) models for disease modeling and drug screening. While various biofabrication techniques have recently been widely reviewed in the literature, acoustics-based technologies still need to be explored. The rapidly increasing number of publications in the past two decades exploring the application of acoustic technologies highlights the tremendous potential of these technologies. In this review, we contend that acoustics-based methods can address many limitations inherent in other biofabrication techniques due to their unique advantages: noncontact manipulation, biocompatibility, deep tissue penetrability, versatility, precision …

Samd7 Represses Short-Wavelength Cone Genes To Preserve Long-Wavelength Cone And Rod Photoreceptor Identity, Leo I Volkov, Yohey Ogawa, Ramiz Somjee, Hannah E Vedder, Hannah E Powell, Deepak Poria, Sam Meiselman, Vladimir J Kefalov, Joseph C Corbo

2020-Current year OA Pubs

The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge of the cell-type-specific function of transcriptional cofactors remains incomplete. Here, we show that the transcriptional corepressor

Archeologically Speaking For Texas, Marvin Glasgow

North Texas Archeological Society Records

A archeological dictionary with common words in Texas archeology, dated for 2003.

Dehydration And Traumatic Brain Injury: A Pilot Study Of A Translational Rodent Model Of Conditions In Professional Combat Sports, Alexander S. Martinie, Corey Peacock, Chris Algeri, Bill Kochen

Journal for Sports Neuroscience

Traumatic brain injuries are a widespread public health issue, with athletes being at an increased risk of traumatic brain injury, especially in contact sports. Dehydration and rehydration prior to use of a weight drop served as a model for conditions experienced by professional boxers in a rodent model of traumatic brain injury. Following dehydration, rehydration, and traumatic brain injury procedures, subjects’ symptoms were assessed using the novel object recognition task, sucrose preference test, open field maze, and elevated zero maze. There were significant effects of both dehydration and TBI on time to righting, and there was a significant interaction between …

New Ichnofossil Discovery In Mallorcan Caves: Linking Ancient And Moden Bat-Ectoparasites Coporolites., Antonio Merino Juncadella, Joan J. Fornós, Antoni Mulet, Joaquin Gines

International Journal of Speleology

Bat ectoparasitic ichnofossils can be useful to elucidate microbial mediation in mineralization processes of organic material, supplying valuable information on ancient parasitology and palaeoecology, among other topics. Rod-shaped features found in Cova des Pas de Vallgornera (Mallorca, Spain) are described for the first time. They are related to an ancient bat colony inhabiting the cave in the Early Pleistocene. These micro-morphologies are cylindrical in shape with sizes of a few hundred microns in length and less than one hundred microns in diameter. They are composed by a mash of microscopic calcite particles of different sizes and shapes, lying on deposits …