Digital Commons Network^™

Synthesis And Characterization Of Titanium And Vanadium Nitride–Carbon Composites, Helia Magali Morales, David A. Sanchez, Elizabeth M. Fletes, Michael Odlyzko, Victoria Padilla, Mataz Alcoutlabi, Jason Parsons

Mechanical Engineering Faculty Publications

Titanium nitride and vanadium nitride–carbon-based composite systems, TiN/C and VN/C, were prepared using a new synthesis method based on the thermal decomposition of titanyl tetraphenyl porphyrin (TiOTPP) and vanadyl tetraphenyl porphyrin (VOTPP), respectively. The structure of the TiN/C and VN/C composite materials, as well as their precursors, were characterized using Fourier Transformed Infrared Spectroscopy, X-Ray diffraction (XRD), X-Ray energy dispersive (EDS) and X-Ray photoelectron spectroscopy (XPS). Morphologies of the TiN/C and VN/C composites were examined by means of scanning electron (SEM) and transmission electron (TEM) microscopy. The synthesis of the non-metalated tetraphenyl porphyrin, the titanium, and vanadium tetraphenyl porphyrin complexes …

Effects Of Surface Treatment On Adhesive Performance Of Composite-To-Composite And Composite-To-Metal Joints, Nikhil Paranjpe, Md. Nizam Uddin, Akm S. Rahman, Ramazan Asmatulu

Publications and Research

This study deals with the long-running challenge of joining similar and dissimilar materials using composite-to-composite and composite-to-metal joints. This research was conducted to evaluate the effects of surface morphology andsurfacetreatments onthemechanicalperformanceofadhesively bonded joints used for the aircraft industry. A two-segment, commercially available, toughened epoxy was chosen as the adhesive. Unidirectional carbon fiber prepreg and aluminum 2021-T3 alloys were chosen for the composite and metal panels, respectively. Surface treatment of the metal included corrosion elimination followed by a passive surface coating of Alodine®. A combination of surface treatment methods was used for the composite and metal specimens, including detergent cleaning, plasma …

Advanced Magnetic Sensing Technologies For Enhanced Biodetection And Healthcare Monitoring, Kee Young Hwang

USF Tampa Graduate Theses and Dissertations

The development of biosensing systems that leverage the unique properties of magnetic nanoparticles and the high sensitivity of magnetic sensors for detecting biomolecules and cancer cells has been an active area of research. However, challenges remain in detecting and differentiating the magnetic signals of biomarkers made from nanoparticles that have similar sizes but distinct magnetic properties. Additionally, overcoming the reduction in detection sensitivity caused by non-magnetic coatings on magnetic nanoparticles remains a key hurdle. Concurrently, there is a pressing need to develop advanced magnetic sensor technologies that can enhance existing healthcare monitoring systems and enable more precise, real-time diagnostics.This dissertation …

Optimal Management Of Patients With Moderate-To-Severe Inflammatory Bowel Disease, Tugrul Purnak, Atilla Ertan

Faculty, Staff and Student Publications

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and often debilitating condition requiring complex and individualized management. Over the past few decades, advancements in understanding IBD pathophysiology have led to a transformative shift in therapeutic approaches. This article provides a comprehensive overview of the evolution of IBD treatments, from early symptom-focused therapies to modern biologics, small molecule agents, and emerging treatment strategies. We discuss therapeutic goals centered on achieving clinical remission, endoscopic/mucosal healing, and enhancing patient quality of life. Additionally, we explore the rationale for the early and personalized use of biologic therapies …

Multi-Institutional Report Of Trastuzumab Deruxtecan And Stereotactic Radiosurgery For Her2 Positive And Her2-Low Breast Cancer Brain Metastases, Sreenija Yarlagadda, Reshma Mahtani, Manmeet Ahluwalia, Rupesh Kotecha

All Publications

Trastuzumab-deruxtecan (T-DXd) has demonstrated intracranial efficacy; however, safety and efficacy data remains limited with stereotactic radiosurgery (SRS). A multi-institutional review was performed with HER2+ or HER2-low metastatic breast cancer treated with T-DXd and SRS for active brain metastases. We identified 215 lesions treated over 48 SRS courses in 34 patients. Median follow up from T-DXd initiation was 13.9 months. The cumulative incidence of symptomatic radiation necrosis at 24 months per lesion was 2.1% and per patient 11%. The 12-month LC was 97%. HER2-low was associated with worse distant intracranial control (DIC) (adjusted HR 2.5, 95% CI 1.1-5.6, p = 0.03) …

Kenyon Collegian - November 21, 2024

The Kenyon Collegian

No abstract provided.

2024-11-21 Fall Fep Reviews, Morehead State University. Faculty Senate., Evaluation Committee.

Faculty Senate Records

Evaluation Committee FEP reviews report submitted to the Faculty Senate on November 21, 2024.

Dog Sniffing Biomechanic Responses In An Odor Detection Test Of Odorants With Differing Physical Properties, Lydia Burnett, Nicholas Hebdon, Pete A. Stevens, Monica Moljo, Lindsay D. Waldrop, Lauryn Degreeff

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Dogs are utilized in forensic science for their extensive scent detection capabilities. They are often considered the “gold standard” in field detection for targets such as illicit drugs and explosives. Despite their prevalence in the field, relatively little is known about how dogs interact with and transport volatile organic compounds through their olfactory system. In this study, two groups of dogs were utilized – Sport detection dogs (n=19) that participate in the National Association of Canine Scent Work and have achieved advanced standing through training and successful search competitions and law enforcement explosive detection dogs (n=8) which were included for …

Plasmodium Berghei Liver Stage Parasites Exploit Host Gabarap Proteins For Tfeb Activation, Jacqueline Schmuckli-Maurer, Annina F Bindschedler, Rahel Wacker, Oliver M Würgler, Ruth Rehmann, Timothy Lehmberg, Leon O Murphy, Thanh N Nguyen, Michael Lazarou, Jlenia Monfregola, Andrea Ballabio, Volker T Heussler

Duncan NRI Faculty and Staff Publications

Plasmodium, the causative agent of malaria, infects hepatocytes prior to establishing a symptomatic blood stage infection. During this liver stage development, parasites reside in a parasitophorous vacuole (PV), whose membrane acts as the critical interface between the parasite and the host cell. It is well-established that host cell autophagy-related processes significantly impact the development of Plasmodium liver stages. Expression of genes related to autophagy and lysosomal biogenesis is orchestrated by transcription factor EB (TFEB). In this study, we explored the activation of host cell TFEB in Plasmodium berghei-infected cells during the liver stage of the parasite. Our results …

Comparison Of The Bristol Stool Scale And Modified Version For Children: Use By Providers Vs Children, James Orozco, Mariella M Self, Sara Grisales, Bruno P Chumpitazi, Danita I Czyzewski, Meagan S Mcmullen, Rebecca Berger, Clarissa A Gonzalez, Amber L Cunha, Robert J Shulman

Faculty, Staff and Students Publications

Introduction: Accurate report of stool form is essential to diagnosis and assessment of treatment response. The modified Bristol Stool Form Scale for Children (mBSFS-C) classifies stool form into 5 types and is reliable and valid. However, a direct comparison of provider's and children's ratings using the mBSFS-C vs the traditional BSFS that uses 7 stool form types has not been done.

Methods: Pediatric gastroenterology providers and children rated the same 35 stool photographs, reflecting diverse stool forms, using both scales. The order of photograph presentation and scale use were randomized. For each photograph, the most common rating (modal rating) was …

Insights Into Human Norovirus Cultivation In Human Intestinal Enteroids, Khalil Ettayebi, Gurpreet Kaur, Ketki Patil, Janam Dave, B Vijayalakshmi Ayyar, Victoria R Tenge, Frederick H Neill, Xi-Lei Zeng, Allison L Speer, Sara C Di Rienzi, Robert A Britton, Sarah E Blutt, Sue E Crawford, Sasirekha Ramani, Robert L Atmar, Mary K Estes

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century. This barrier was overcome with our successful cultivation of multiple HuNoV strains in human intestinal enteroids (HIEs), which has significantly advanced HuNoV research. We optimized culture media conditions and generated genetically modified HIE cultures to enhance HuNoV replication in HIEs. Building upon these achievements, we now present new insights into this culture system, which involve testing different media, unique HIE lines, and additional virus strains. HuNoV infectivity …

Genotype-Specific Effects Of Elamipretide In Patients With Primary Mitochondrial Myopathy: A Post Hoc Analysis Of The Mmpower-3 Trial, Amel Karaa, Enrico Bertini, Valerio Carelli, Bruce Cohen, Gregory M Ennes, Marni J Falk, Amy Goldstein, Gráinne Gorman, Richard Haas, Michio Hirano, Thomas Klopstock, Mary Kay Koenig, Cornelia Kornblum, Costanza Lamperti, Anna Lehman, Nicola Longo, Maria Judit Molnar, Sumit Parikh, Han Phan, Robert D S Pitceathly, Russekk Saneto, Fernando Scaglia, Serenella Servidei, Mark Tarnopolsky, Antonio Toscano, Johan L K Van Hove, John Vissing, Jerry Vockley, Jeffrey S Finman, Anthony Abbruscato, David A Brown, Alana Sullivan, James A Shiffer, Michelango Mancuso, Mmpower-3 Trial Investigators

Faculty, Staff and Students Publications

BACKGROUND: As previously published, the MMPOWER-3 clinical trial did not demonstrate a significant benefit of elamipretide treatment in a genotypically diverse population of adults with primary mitochondrial myopathy (PMM). However, the prespecified subgroup of subjects with disease-causing nuclear DNA (nDNA) pathogenic variants receiving elamipretide experienced an improvement in the six-minute walk test (6MWT), while the cohort of subjects with mitochondrial DNA (mtDNA) pathogenic variants showed no difference versus placebo. These published findings prompted additional genotype-specific post hoc analyses of the MMPOWER-3 trial. Here, we present these analyses to further investigate the findings and to seek trends and commonalities among those …

Experience Of Stress And Coping Among Male Police Officers In Trinidad And Tobago, Coryse Penco

Walden Dissertations and Doctoral Studies

Police officers in Trinidad and Tobago face highly stressful environments due to increasing violent crimes and threats to their lives. Organizational stress contributes to emotional exhaustion, highlighting the need for research on stress and coping among these officers. The purpose of this basic qualitative study was to explore job-related stressors and coping strategies that male police officers in Trinidad and Tobago use to deal with their everyday job demands. Han Selye’s theory of stress and Lazarus’ transactional model of stress and coping were used as theoretical frameworks for this study. Semi-structured interviews were conducted with 12 male police officers from …

Does Muscle Pain Induce Alterations In The Pelvic Floor Motor Unit Activity Properties In Interstitial Cystitis/Bladder Pain Syndrome? A High-Density Semg-Based Study, Monica Albaladejo-Belmonte, Michael Houston, Nicholas Dias, Theresa Spitznagle, Henry Lai, Yingchun Zhang, Javier Garcia-Casado

2020-Current year OA Pubs

Several studies have shown interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic condition that poses challenges in both diagnosis and treatment, is associated with painful pelvic floor muscles (PFM) and altered neural drive to these muscles. However, its pathophysiology could also involve other alterations in the electrical activity of PFM motor units (MUs). Studying these alterations could provide novel insights into IC/BPS and help its clinical management. This study aimed to characterize PFM activity at the MU level in women with IC/BPS and pelvic floor myalgia using high-density surface electromyography (HD-sEMG). Signals were recorded from 15 patients and 15 healthy controls …

Vol. 10, No. 3, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Why Share A Language Or Tradition? Gadamer And Davidson In Dispute, Bart Vandenabeele

Budhi: A Journal of Ideas and Culture

That the ideal way to communicate and reach understanding is by speaking the same language, is a widespread view: it is rarely questioned in debates concerning language, (intercultural) communication, and interpretation. I shall argue that Hans-Georg Gadamer, too, suffers from this common language “syndrome.” Donald Davidson is one of the few philosophers who explicitly uttered qualms about the necessity of a common language. Davidson critiques Gadamer’s common language idea, and rightly claims that a common language is not needed for communication and understanding. I show that Davidson has been unable to develop this insight fruitfully and underestimates the importance of …

Exploring Pcat3 Expression In Arthritis: Proinflammatory Marker Patterns And P53 Involvement, Aida H. Alobaidi, Entkhab M. A. Alanisi, Khalid A. Alyodawi

AUIQ Complementary Biological System

This study investigated the role of long non-coding RNA (lncRNA) PCAT3 in arthritis, focusing on its impact on proinflammatory markers. Researchers analyzed both mRNA and protein levels of various proinflammatory markers (TNF-α, IL-1β, IL-4, IL-6, IL-8, IL-10, and IL-13) in arthritis patients and compared them to healthy controls. Additionally, PCAT3 expression was assessed in both patient groups and further investigated using siRNA knockdown in the human synovial cell line SW982. Results revealed distinct expression patterns of proinflammatory markers in arthritis patients, with TNF-α and IL-6 showing the highest levels. PCAT3 expression was significantly elevated in arthritis patients compared to controls. …

Accessibility Of National Parks And Other Natural Protected Areas For People With Disabilities: A Scoping Review Of The Academic Literature, Mark Weiler, Alison Whiting, Waqas Sajid, Neha Dewan, Tilak Dutta

Library Publications

National parks and protected wilderness areas provide benefits through leisure activities to many. Yet, many people with disabilities are unable to experience these benefits because of barriers. Therefore, it is important to understand how to improve access to these spaces for people with disabilities. The objective of this study is to identify barriers and facilitators to accessibility in national parks and protected natural areas. Using a scoping review methodology, we searched eighteen academic databases and found 44 sources meeting our eligibility criteria. Our findings include tables that map the literature by publication year, types of disabilities, specific national parks, park …

Payment Disrupters And Opportunities: Key Trends That Impacted Pharmacy In 2024, Craig Kimble, Thomas Pile, Alberto Coustasse

Management Faculty Research

In 2023, the United States experienced the most significant increase in prescription drug spending (13.6%), totaling $89 billion.1 This was driven by higher utilization and the introduction of new, expensive specialty and biotech drugs. In 2024, other factors continue to drive costs and disrupt the pharmacy landscape, including the implementation of new business models, pharmacy benefit manager (PBM) practices, the rebate system, regulatory changes, advancements in provider status, and potential Federal Trade Commission (FTC) interventions.

November 20, 2024, Faculty, Illinois Wesleyan University

2024-2025

No abstract provided.

The Family History Of Whitten B. O’Neal, Whitten O'Neal

Your Family in History: HIST 550/700

The Family History of

Whitten B. O’Neal

19 September 2024

Whitten O’Neal authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Fall 2024 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The Family History Of Elijah R. Clymer, Elijah Clymer

Your Family in History: HIST 550/700

Mr. Elijah Clymer authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Fall 2024 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]

Motivational Dysregulation With Melanocortin 4 Receptor Haploinsufficiency, Alex M. Steiner, Robert F. Roscoe, Rosemarie M. Booze, Charles F. Mactutus

Faculty Publications

Obesity, by any standard, is a global health crisis. Both genetic and dietary contributions to the development and maintenance of obesity were integral factors of our experimental design. As mutations of the melanocortin 4 receptors (MC4R) are the leading monogenetic cause of obesity, MC4R haploinsufficient rats were fed a range of dietary fat (0–12 %) in a longitudinal design. Physiological and motivational assessments were performed using a locomotor task, a 5-choice sucrose preference task, an operant task with fixed and progressive ratios, as well as a distraction operant task. Dendritic spine morphology of medium spiny neurons (MSNs) of the nucleus …

Fall 2024 Student Showcase For Research And Creative Inquiry Program, Office Of Student Research, Longwood University

Fall Showcase for Research and Creative Inquiry

No abstract provided.

November 20, 2024 Nagpra And Tribal Relations Committee Meeting Minutes, Bryan Morey

University NAGPRA and Tribal Relations Committee

Minutes from the November 20, 2024 meeting of Western Kentucky University's NAGPRA and Tribal Relations Committee. The meeting was conducted via Zoom.

Limosilactobacillus Reuteri Ameliorates Maternal Separation Stress In Newborn Mice And Alters Subsequent Adult Behaviour, Z. M. Saleh, B. Okeugo, V. R. Venna, F. W. Blixt, V. A. Quaicoe, E. S. Park, S. Giorgberidze, Meng Luo, Christopher M. Taylor, J. M. Rhoads, Y. Liu

School of Medicine Faculty Publications

Maternal separation (MS) in mice results in behavioral deficits and gut microbiota dysbiosis that all persist into adulthood. Limosilactobacillus reuteri DSM 17938 modulates gut microbiota, alters systemic metabolites, and facilitates immune regulation. To assess the effect of DSM 17938 on biochemical and behavioural stress-associated changes, newborn mice were exposed to unpredictable MS (MSU) daily from day 7 to day 20 of life, with intragastric administration of DSM 17938 or PBS as control. Body weight, brain levels of cholecystokinin (CCK), glial fibrillary acidic protein (GFAP), corticosterone, and stool microbiota were assessed at day 21. Behaviour tests including Y-maze (YMT), Tail Suspension …

Red Harvester Ants Pogonomyrmex Barbatus (Smith, 1858) (Hymenoptera: Formicidae) Do Not Distinguish Between Sorghum Head Mold Symptomatic And Asymptomatic Seeds, Lilly Victoria Elliott-Vidaurri, Hannah J. Penn, Robin A. Choudhury

School of Earth, Environmental, & Marine Sciences Faculty Publications

Red harvester ants, Pogonomyrmex barbatus (Smith, 1858) (Hymenoptera: Formicidae), common in the Lower Rio Grande Valley of Texas, are known to gather seeds from areas around their nests and store the seeds inside their nests for later consumption. As these ants often nest in and near agricultural fields, some of these seeds may be from crops and may also be infected with fungal plant pathogens. These pathogens can degrade seed coats and may cause the seeds to rot within the ant nests, decreasing storage time and potentially spreading the pathogen to other stored seeds. We studied how head mold, a …

The Bg News November 20, 2024, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 20, 2024. Volume 104-Issue 12.

Immune Responses Drive Chorioretinitis And Retinal Pathology After Neonatal Cmv Infection, Jessica L. Mccord, John Y.S. Han, Ross E. Staudt, Nancy J. Philp Phd, Christopher M. Snyder

Department of Microbiology and Immunology Faculty Papers

Human cytomegalovirus (CMV) causes a common congenital infection leading to long-term neurological impairments including brain, cochlear, and ocular pathology. Infection of newborn mice with murine (M)CMV is an established model of neuropathology caused by congenital CMV infection, with recent work suggesting that brain pathology may be driven by immune responses. In the eye, however, CMV retinitis is thought to result from virus-driven necrosis in the absence of T cell responses. We found that MCMV infection of newborn mice recapitulates human eye disease after congenital CMV infection, including focal chorioretinitis, inflamed vasculature, and disrupted blood-retinal barriers. Moreover, infection drove extensive T …

No. 108 An Order To Conserve The Duck River Watershed, Bill Lee

Executive Orders

No abstract provided.