Digital Commons Network^™

Make America Healthy: Reducing High Pharmaceutical Prices Without Reducing Innovation, Srividhya Ragavan

Faculty Scholarship

Cost of medication in the United States has historically remained one of the highest in the world. The conundrum that the United States has faced in balancing innovation with affordability of life-saving medications is palpable, especially when faced with the reality of patent monopolies conflicting with healthcare obligations. The result is an overflow of issues, which emphasize the need to delineate limits on innovation to balance pharmaceutical novelty with robust public health within the United States. This has increasingly shifted the focus of patent law into the realm of healthcare issues. Naturally, it leads to an inquiry about how best …

China, The Trips Waiver, And The Global Pandemic Response, Peter K. Yu

Faculty Scholarship

This chapter identifies three distinct reasons why China took a middle-of-the-road position in the debate on the COVID-19 TRIPS waiver at the WTO. It also recounts the country’s more assertive position in the run-up to the adoption of the Ministerial Decision on the waiver. Drawing eight lessons from the international debate on the waiver and the subsequent Ministerial Decision, the chapter offers insights into the future role China can or will play in future international policy debates at the intersection of intellectual property and public health, including during the next pandemic.

Characterization Of An Acetogenin-Carrying Nanosuspension And Its Effect On Bacteria Of Interest In The Poultry Industry, Brandon A. Lopez-Romero, Gabriela Aguilar-Hernandez, Billy M. Hargis, Maria De Lourdes Garcia-Magana, Ulises M. Lopez-Garcia, Rosa I. Ortiz-Basurto, Adalberto Zamudio-Ojeda, Juan D. Latorre, Efigenia Montalvo-Gonzalez

Poultry Science Faculty Publications and Presentations

This work aimed to develop a nanosuspension (NSps) as an acetogenin (ACGs) carrier, using soy lecithin (SL) and hydroxypropyl-β-cyclodextrin (βCD) named NSps-βCDSL-ACGs. It was characterized by various spectroscopic techniques (DLS, FTIR, UV-vis diffuse reflectance). Moreover, the NSps morphology was observed by transmission electron microscopy (TEM). Also, the antibacterial activity of NSps-βCDSL-ACGs was evaluated against strains of interest in the poultry sector. NSps-βCDSL-ACGs presented nanometric size (207–239 nm), acceptable polydispersity index (PDI) values (0.13–0.17) and a high Z potential value (−47.17–50.36 mV), demonstrating high stability. The presence of ACGs in NSps-βCDSL-ACGs was confirmed by FTIR analysis. The nanoparticles had a spherical …

Ai Regulation Has Its Own Alignment Problem: The Technical And Institutional Feasibility Of Disclosure, Registration, Licensing, And Auditing, Neel Guha, Christie M. Lawrence, Lindsey A. Gailmard, Kit T. Rodolfa, Faiz Surani, Rishi Bommasani, Inioluwa Deborah Raji, Mariano-Florentino Cuéllar, Colleen Honigsberg, Percy Liang, Daniel E. Ho

Faculty Scholarship

Calls for regulating artificial intelligence (“AI”) are widespread, but there remains little consensus on both the specific harms that regulation can and should address and the appropriate regulatory actions to take. Computer scientists propose technical solutions that may be infeasible or illegal; lawyers propose regulation that may be technically impossible; and commentators propose policies that may backfire. AI regulation, in that sense, has its own alignment problem, in which proposed interventions are often misaligned with societal values.This Article assesses the alignment and technical and institutional feasibility of four dominant proposals for AI regulation in the United States: disclosure, registration, licensing, …

Rice Response To Struvite And Other Phosphorus Fertilizers In A Phosphorus-Deficient Soil Under Simulated Furrow-Irrigation, Jonathan B. Brye, Diego Della Lunga, Kristofor R. Brye

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Wastewater-recovered phosphorus (P), in the form of the mineral struvite (MgNH₄PO₄⋅6H₂O), may provide a sustainable alternative to decreasing rock-phosphate reserves. Struvite can be generated via precipitation methods, potentially reducing the amount of P runoff to aquatic ecosystems. The objective of this greenhouse tub study was to evaluate the effects of chemically- and electrochemically precipitated struvite (CPST and ECST, respectively) on above- and belowground plant response in a hybrid rice (Oryza sativa) cultivar grown using furrow-irrigation compared to other common fertilizer-P sources [i.e., triple super phosphate (TSP) and diammonium phosphate (DAP)]. Rice was …

Low Intensity Mechanical Signals Promote Proliferation In A Cell-Specific Manner: Tailoring A Non-Drug Strategy To Enhance Biomanufacturing Yields, M Ete Chan, Christopher Ashdown, Lia Strait, Sishir Pasumarthy, Abdullah Hassan, Steven Crimarco, Chanpreet Singh, Vihitaben S Patel, Gabriel Pagnotti, Omor Khan, Gunes Uzer, Clinton T Rubin

Faculty, Staff and Student Publications

Biomanufacturing relies on living cells to produce biotechnology-based therapeutics, tissue engineering constructs, vaccines, and a vast range of agricultural and industrial products. With the escalating demand for these bio-based products, any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the discipline. While these goals are primarily achieved using biological or chemical strategies, harnessing cell mechanosensitivity represents a promising - albeit less studied - physical pathway to promote bioprocessing endpoints, yet identifying which mechanical parameters influence cell activities has remained elusive. We tested the hypothesis that mechanical signals, delivered non-invasively …

Healthcare Disparities, Screening, And Molecular Testing In The Changing Landscape Of Non-Small Cell Lung Cancer In The United States: A Review, Razelle Kurzrock, Aadel A Chaudhuri, David Feller-Kopman, Narjust Florez, Jed Gorden, Ignacio I Wistuba

Faculty, Staff and Student Publications

Inequitable access to care continues to hinder improvements in diagnosis and treatment of lung cancer. This review describes healthcare disparities in the changing landscape of non-small cell lung cancer (NSCLC) in the United States, focusing on racial, ethnic, sex-based, and socioeconomic trends. Furthermore, strategies to address disparities, overcome challenges, and improve patient outcomes are proposed. Barriers exist across lung cancer screening, diagnosis, and treatment regimens, varying by sex, age, race and ethnicity, geography, and socioeconomic status. Incidence and mortality rates of lung cancer are higher among Black men than White men, and incidences in young women are substantially greater than …

Aging-Associated Mechanisms Of Atrial Fibrillation Progression And Their Therapeutic Potential, Shuai Zhao, Aaron M Johnston, Chi Him Kendrick Yiu, Lucia M Moreira, Svetlana Reilly, Xander H T Wehrens

Faculty, Staff and Students Publications

Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart contribute to an increased AF susceptibility. This work critically reviews the key molecular mechanisms that may underpin the complex association between aging and AF. Moreover, we identify emerging novel opportunities for therapeutic intervention that may be able to prevent and/or improve the current treatment paradigms for age-related AF. This review contributes to a holistic understanding of the intricate relationship between aging and AF.

Environmental Transport And Sorting Of Glass Retroreflective Microbeads And Their Potential As Proxies For Road Marking Paints, Andrew Turner, Adam Bridgwater, Emily Marshall

School of Geography, Earth and Environmental Sciences

Road marking paints are a potentially important contributor to the global microplastic pool but very little reliable information is available on their erosion or environmental distributions. As potential carriers of or proxies for road paints, we determine the concentrations and sorting of retroreflective glass microbeads in marking materials and in fractionated (< 5 mm) local dusts, soils and sediments. As an aid to our investigation, we also determine the concentrations of metals of geochemical significance or components of road paint pigments in markings and geosolids. Concentrations of beads up to 92,800 kg⁻¹ were observed in street dusts, with a median diameter (350 μm) greater than that in road marking samples (270 μm). Few beads were found in adjacent (< 5 m) or more remote soils (six beads in ten 50-g samples) and none were detected in replicates of a sample of roof dust, suggesting that aeolian transport is limited. Concentrations up to 3700 kg⁻¹ were found in estuarine sediments close to bridges or stormwater runoff effluents, and with increasing sediment depth concentrations and …

Demystifying Research Paradigms: Navigating Ontology, Epistemology, And Axiology In Research, Lynette Pretorius

The Qualitative Report

A sound understanding of research paradigms is crucial for developing coherent and philosophically grounded research designs, particularly in the humanities and social sciences. This paper offers an accessible overview of the most common research paradigms: positivism, post-positivism, constructivism, social constructionism, interpretivism, pragmatism, and critical realism. These paradigms differ in their approaches to ontology (the nature of reality), epistemology (the nature of knowledge), and axiology (the role of values in research). The paper also discusses the methodological and ethical implications of these paradigms. Reflexivity and ethical responsibility are emphasised, where researchers must account for how their own biases and values influence …

Anthocyanin Extraction Methods: Synthesis Of Morpho-Anatomical Knowledge For Decision-Making Based On Decision-Tree, Gabriel Laquete De Barros, F.T.S. Silva, R.S. Teixeira, J.G. Wagner, C.V. Rombaldi, M. Vizzotto, A. Ubeyitogullari, L. Nora

Biological and Agricultural Engineering Faculty Publications and Presentations

Efficient anthocyanin extraction from emerging food matrices is essential in food technology and requires a precise, consistent, and clear extraction method. This study aimed to develop a decision-tree tool for selecting the optimal anthocyanin extraction technique. A comprehensive data synthesis covering the years 2018 to 2023 was conducted using leading academic databases, including Web of Science, Scopus, Medline, and SciELO. A combination of systematic and non-systematic approaches was employed to guide the decision-making process. The keywords used included “anthocyanin extraction methods,” and studies with more than 10 citations were prioritized, along with recent and relevant publications. Thirty-six articles were analyzed …

Rate Coefficients For Rotational State-To-State Transitions In H2O + H2 Collisions As Predicted By Mixed Quantum–Classical Theory, Carolin Joy, Dulat Bostan, Bikramaditya Mandal, Dmitri Babikov

Chemistry Faculty Research and Publications

Aims. A new dataset of collisional rate coefficients for transitions between the rotational states of H₂O collided with H₂ background gas is developed. The goal is to expand over the other existing datasets in terms of the rotational states of water (200 states are included here) and the rotational states of hydrogen (10 states). All four symmetries of ortho- and para-water combined with ortho- and para-hydrogen are considered.

Methods. The mixed quantum–classical theory of inelastic scattering implemented in the code MQCT was employed. A detailed comparison with previous datasets was conducted to ensure that this …

Relative Muscular Effort In The Older Adults During The Sit-To-Stand Task: Monitoring Neuromuscular Reserve And Movement Limitations, Nayun Ahn, Michael H. Haischer, Cara L. Lewis, Kristof Kipp

Exercise Science Faculty Research and Publications

Background

Due to lower maximum strength, older adults purportedly need to exert greater muscular effort to stand up from a chair. This study investigated joint-specific muscular effort during a sit-to-stand by calculating relative-muscular-effort and investigating differences between healthy older and young adults.

Methods

Fifteen older (age: 69.9 ± 3.5 years) and 15 young (age: 22.2 ± 2.6 years) adults performed five self-paced sit-to-stand trials. Kinematic and kinetic data were collected and used to calculate inverse dynamics net joint moment. Peak isometric knee and hip extensor torques were measured and used as inputs to regression models that predicted angle- and velocity-dependent …

Intellectual Property, Global Inequality, And Subnational Policy Variations, Peter K. Yu

Faculty Scholarship

This chapter criticizes the oversimplification of the binary North–South debate on intellectual property, innovation, and global inequality and highlights the wide geographic, sectoral, and income inequalities within middle-income countries. It begins by explaining why the arrival of these countries has called into question the North–South debate. The chapter then moves from the widely studied subject of global inequality to the underexplored topic of national inequality. Focusing on the intellectual property context, the discussion highlights the considerable subnational variations in the economic and technological conditions of middle-income countries. To combat national inequality, this chapter concludes by recommending interventions in three areas: …

Reframing A Data Sharing Mechanism For The Riparian Nations Of Helmand River Basin: Theory Of Planned Behavior Is Revisited, Najibullah Loodin, Gabriel Eckstein, Vijay P. Singh, Rosario Sanchez

Faculty Scholarship

Data and information exchange plays a crucial role in fostering water cooperation between the riparian nations of a shared watercourse. Taking an integrated approach combining Discourse Analysis and Document Analysis, this research aims at elucidating the challenges and the potential opportunities of data and information exchange on the Helmand River, a drought-stricken river basin shared between upstream Afghanistan and downstream Iran. Drawing on the Theory of Planned Behavior (TPB), we offer nuanced perspectives on the data exchange model developed by Wehn. We argue that there are other underlying and essential elements that hinder the meaningful engagement of the riparian nations …

Reducing Dna Extraction Costs Through Factorial Design For The Dnadvance Kit, Carson J. Neal, Zachery D. Zbinden, Michael E. Douglas, Marlis R. Douglas

Biological Sciences Faculty Publications and Presentations

Objective

Extracting DNA is essential in wildlife genetic studies, and numerous methods are available. However, the process is costly and time-consuming for non-model organisms, including most wildlife species. Therefore, we optimized a cost-efficient protocol to extract DNA from the muscle tissue of White-tailed Deer using the DNAdvance kit (Beckman Coulter), a magnetic-bead-based approach. We devised a 3 × 3 factorial design using combinations of tissue mass (10 mg, 50 mg, or 100 mg) and reaction volume (25%, 33%, and 50% of the manufacturer's recommended volumes). DNA was extracted for N = 81 tissue sub-samples (9 replicates/treatment).

Results

Our target yield …

Mesoporous Silica Administration As A New Strategy In The Management Of Warfarin Toxicity: An In-Vitro And In-Vivo Study, Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose:

Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. Warfarin overdose, whether intentional or unintentional, can cause life-threatening bleeding. Here, we present a novel warfarin adsorbent based on mesoporous silica that could serve as an antidote to warfarin toxicity.

Methods:

Amino-functionalized mesoporous silica (MS-NH2) was synthesized based on the co-condensation method through a soft template technique followed by template removal. The prepared structure and functional group were studied by Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) checked the morphology. The …

The Effects Of Wildfires On Predation Risk, Perch Selection, And Background-Matching In Western Fence Lizards, Elmer Ernesto Gutierrez

Electronic Theses, Projects, and Dissertations

Fires are a naturally occurring phenomenon, driving a range of behavioral, reproductive, and morphological adaptations in wildlife. However, we are now living in a new geological epoch—the Pyrocene—characterized by human-induced extreme fire behavior. This shift results in a need to understand how animals survive and adapt in post-fire environments. In this study, we investigated the following questions: (1) Does predation risk increase in burned habitats after a fire? (2) How does dorsal darkness morphology vary between burned and unburned habitats? and (3) Do animals select perches that enhance their background-matching in post-fire environments? We used the Western Fence Lizard ( …

Exploring The Impact Of Leaders’ Emotional Intelligence On Employee Retention And Job Satisfaction: An Employee-Centric Perspective, Stacia Mccambridge

Electronic Theses, Projects, and Dissertations

Employee retention and job satisfaction are crucial for the success of higher education institutions, as turnover incurs high costs and disrupts operations. This qualitative phenomenological study explored how leaders’ emotional intelligence, as defined by self-awareness, self-management, social awareness, and relationship management emotional intelligence, impacts employee satisfaction and retention in university settings in Southern California. The theoretical framework used for this study was the emotional intelligence theoretical framework of Goleman et al. (2002), which includes self-awareness, self-management, social awareness, and relationship management competencies to conduct surveys and interviews. The two research questions that guided this study of how employees described, based …

Precision And Efficacy Of Rna-Guided Dna Integration In High-Expressing Muscle Loci, Made Harumi Padmaswari, Gabrielle Bulliard, Shilpi Agrawal, Mary S. Jia, Sabin Khadgi, Kevin A. Murach, Christopher E. Nelson

Biomedical Engineering Faculty Publications and Presentations

Gene replacement therapies primarily rely on adeno-associated virus (AAV) vectors for transgene expression. However, episomal expression can decline over time due to vector loss or epigenetic silencing. CRISPR-based integration methods offer promise for long-term transgene insertion. While the development of transgene integration methods has made substantial progress, identifying optimal insertion loci remains challenging. Skeletal muscle is a promising tissue for gene replacement owing to low invasiveness of intramuscular injections, relative proportion of body mass, the multinucleated nature of muscle, and the potential for reduced adverse effects. Leveraging endogenous promoters in skeletal muscle, we evaluated two highly expressing loci using homology-independent …

Introduction To Intellectual Property, Innovation And Economic Inequality, Daniel Benoliel, Peter K. Yu

Faculty Scholarship

This chapter provides an introduction to Intellectual Property, Innovation and Economic Inequality. It begins by discussing the problem of economic inequality, including the scale of that problem, types of economic inequality, and extant research on such inequality. The chapter then outlines the structure of this volume, which is divided into three parts: (1) theoretical, empirical, and policy issues; (2) intellectual property and national inequality; and (3) intellectual property and global inequality.

Intellectual Property, Innovation And Economic Inequality, Daniel Benoliel, Peter K. Yu, Francis Gurry, Keun Lee

Faculty Scholarship

While growing disparities in wealth and income are well-documented across the globe, the role of intellectual property rights is often overlooked. This volume brings together leading commentators from around the world to interrogate the interrelationship between intellectual property and economic inequality. Interdisciplinary and globally oriented by design, the book features economists, legal scholars, policy analysts, and other experts. Chapters address the impact of intellectual property rights on economic inequality, the effect of economic inequality on the protection and enforcement of these rights, and the potential use of innovation law and policy to help reduce economic inequality. The volume also tackles …

Occupational Performance With Formstack: Academic Fieldwork Coordinator's Perceptions And Experiences, Sara Clark

Dissertations

This multiple descriptive case-study explored the perceptions and experiences of eight occupational therapy program academic fieldwork coordinators (AFWCs), regarding their usage of Formstack, as an online fieldwork data collection system. Previous survey research revealed that AFWCs had positive feelings about the new AOTA Fieldwork Performance Evaluation (AOTA, 2020) housed within Formstack (Sanders & Carpenter, 2024), but the AOTA AFWC national list-serve suggests frustration with the online platform itself. Past research by Sanders and Carpenter (2024) also recommended further investigation into the usability of Formstack. To this end, this inquiry focused on two research questions: (a) How do AFWCs at multiple …

Integrated Transcriptomics And Proteomics Study Of Starvation Selected Drosophila Melanogaster, Aavash Adhikari

UNLV Theses, Dissertations, Professional Papers, and Capstones

Drosophila melanogaster, selected for starvation resistance exhibits phenotypic traits such as increased body size, slower development, reduced fecundity and obesity like characteristics including higher lipid reserves and cardiac dysfunction. While prior studies have explored the metabolic and biochemical changes in these flies, the underlying genetic and molecular mechanisms remain unclear. This study aims to investigate the gene expression and protein abundance in starvation-selected Drosophila through RNAseq, proteomics, and integrating both datasets using the MixOmics package in R. I found differential gene expression in the fat body at the third instar larval stage, particularly in pathways related to lipid metabolism, calcium …

Biological Reduction Of Mixed Oxyanions In Wastewater Brine, Katherine J. Earp

UNLV Theses, Dissertations, Professional Papers, and Capstones

Treatment of contaminated brine water is an area of active research spurred by the use of advanced treatment technologies, such as membrane separation, reverse osmosis, ion exchange, etc. for water reuse and recycling, which has become critical due to the impact of climate change on water resources throughout the globe. Biological reduction of harmful organic and inorganic pollutants in water has been demonstrated as an effective method for water and wastewater treatment and would be a potential technology for brine treatment. However, biodegradation of contaminants in high salinity waters is challenging because most microbial communities cannot survive brine environments. The …

Understanding Levels Of Perceived Racism And Discrimination When Utilizing Perinatal Care, Alexandria S. Evans

UNLV Theses, Dissertations, Professional Papers, and Capstones

Social and structural determinants of health, grounded in historical racism and discrimination, significantly influence maternal health outcomes. Because of this, communities of color experience a higher burden of maternal health disparities. In the last several decades, there has been an increased awareness of the need to integrate critical race theory into public health research to address maternal health disparities in the context of perinatal care delivery, policy, and funding decisions.

This three-manuscript dissertation utilized mixed methods to examine the ways in which systemic racism and discrimination are perceived and how it impacts the utilization of perinatal care services in historically …

Uptake Of Contaminants Of Emerging Concerns (Cecs) By Plants Irrigated With Recycled Waters, Abid Hussain

UNLV Theses, Dissertations, Professional Papers, and Capstones

The increasing demand for water in arid and semi-arid regions necessitates the use of recycled water (RW) for irrigation. RW is a viable alternative to conventional irrigation water at most locations, but it can be a major route for contaminants of emerging concerns (CECs) to be taken up by the tissues of food crops, thereby leading to their subsequent entry into the food chain. CECs include pharmaceuticals, personal care products, and industrial chemicals that are generally present at low concentrations in environmental waters, hence their common designation as trace organic compounds (TOrCs), and CECs also include microbiological constituents such as …

Physiology And Genomics At The Bottom Of The World: Genome To Phenome, Amy Christine Klink

UNLV Theses, Dissertations, Professional Papers, and Capstones

Mammals are exposed to a suite of physiological challenges based on the environment in which they inhabit. Animal individuals can overcome challenges associated with the dynamic nature of their habitat through variation in phenotypic traits. The plasticity of a phenotype relies on an individual’s genome and the transcription factors that act on regulatory elements. Species living in Antarctica display physiological specializations to withstand harsh conditions, such as severe cold temperatures, shifts in available ice habitat, and annual fluctuations in daylight. To explore the connections between an individual’s genome and its phenotype, we investigated two physiologies of the Antarctic Weddell seal …

Using Neighborhood Information To Improve Fiber Direction Estimation From Neuroimaging Data, Anjan Mandal

UNLV Theses, Dissertations, Professional Papers, and Capstones

Accurately estimating neuronal fiber directions is crucial in neuroimaging analysis. The Ball-and-Stick Model (BSM), introduced by Behrens et al. (2003), and widely used in software tools like FSL, remains one of the most popular models for this purpose. BSM analyzes each voxel individually, based solely on its signal information.In this dissertation, we propose modifications to BSM, that incorporate signal information from neighboring voxels in the estimation process, potentially improving the accuracy of the estimates. Additionally, within the estimation process, we introduce two novel proposal distributions to enhance the efficiency of the Markov chain Monte Carlo sampling procedure on the simplex …

Self-Regulated Learning Through Self-Concordant Goals, Social Modeling And Sustainability Focus, Oana Mandrutiu-Iancu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research has shown that when students spend time reflecting and autonomously selecting their college goals, they show high intrinsic motivation, low extrinsic motivation and improvement in emotional and social adjustment over the first several months of college. Despite of this, it is estimated that 77% of first- and second-year students are undecided on their major and many remain undecided as they transition into their junior and senior year. Moreover, in education settings the primary emphasis is on academic success, but focusing solely on academic goals is limiting. As learning is inherently social, academic and social domains cannot be separated, while …