Digital Commons Network^™

Neuroanatomical Variability And Substance Use Initiation In Late Childhood And Early Adolescence, Alex P Miller, David A A Baranger, Sarah E Paul, Hugh Garavan, Scott Mackey, Susan F Tapert, Kimberly H Leblanc, Arpana Agrawal, Ryan Bogdan

2020-Current year OA Pubs

IMPORTANCE: The extent to which neuroanatomical variability associated with early substance involvement, which is associated with subsequent risk for substance use disorder development, reflects preexisting risk and/or consequences of substance exposure remains poorly understood.

OBJECTIVE: To examine neuroanatomical features associated with early substance use initiation and to what extent associations may reflect preexisting vulnerability.

DESIGN, SETTING, AND PARTICIPANTS: Cohort study using data from baseline through 3-year follow-up assessments of the ongoing longitudinal Adolescent Brain Cognitive Development Study. Children aged 9 to 11 years at baseline were recruited from 22 sites across the US between June 1, 2016, and October 15, …

Functional Role Of Myosin-Binding Protein H In Thick Filaments Of Developing Vertebrate Fast-Twitch Skeletal Muscle, Andrew F Mead, Marilyn J Cipolla, Aaron N Johnson, Christina A Gurnett, Et Al.

2020-Current year OA Pubs

Myosin-binding protein H (MyBP-H) is a component of the vertebrate skeletal muscle sarcomere with sequence and domain homology to myosin-binding protein C (MyBP-C). Whereas skeletal muscle isoforms of MyBP-C (fMyBP-C, sMyBP-C) modulate muscle contractility via interactions with actin thin filaments and myosin motors within the muscle sarcomere "C-zone," MyBP-H has no known function. This is in part due to MyBP-H having limited expression in adult fast-twitch muscle and no known involvement in muscle disease. Quantitative proteomics reported here reveal that MyBP-H is highly expressed in prenatal rat fast-twitch muscles and larval zebrafish, suggesting a conserved role in muscle development and …

Secure Messaging Use And Wrong-Patient Ordering Errors Among Inpatient Clinicians, Sunny S Lou, Daphne Lew, Linlin Xia, Laura Baratta, Elise Eiden, Thomas Kannampallil

2020-Current year OA Pubs

IMPORTANCE: Use of secure messaging for clinician-to-clinician communication has increased exponentially over the past decade, but its association with clinician work is poorly understood.

OBJECTIVE: To investigate the association between secure messaging use and wrong-patient ordering errors.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study included inpatient attending physicians, trainee physicians, and advanced practice practitioners (APPs) from 14 academic and community hospitals. Secure messaging volume was assessed over a 3-month period (February 1 to April 30, 2023).

EXPOSURE: Secure messaging volume per clinician-day, measured as the count of secure messages sent and received by a clinician on a given clinician-day.

MAIN …

The Study Of The Epidemiology Of Pediatric Hypertension Registry (Superhero): Rationale And Methods, Andrew M South, Victoria C Giammattei, Kiri W Bagley, Christine Y Bakhoum, William H Beasley, Morgan B Bily, Shupti Biswas, Aaron M Bridges, Rushelle L Byfield, Jessica Fallon Campbell, Rahul Chanchlani, Ashton Chen, Lucy D'Agostino Mcgowan, Stephen M Downs, Gina M Fergeson, Jason H Greenberg, Taylor A Hill-Horowitz, Elizabeth T Jensen, Mahmoud Kallash, Margret Kamel, Stefan G Kiessling, David M Kline, John R Laisure, Gang Liu, Jackson Londeree, Caroline B Lucas, Sai Sudha Mannemuddhu, Kuo-Rei Mao, Jason M Misurac, Margaret O Murphy, James T Nugent, Elizabeth A Onugha, Ashna Pudupakkam, Kathy M Redmond, Sandeep Riar, Christine B Sethna, Sahar Siddiqui, Ashley L Thumann, Stephen R Uss, Carol L Vincent, Irina V Viviano, Michael J Walsh, Blanche D White, Robert P Woroniecki, Michael Wu, Ikuyo Yamaguchi, Emily Yun, Donald J Weaver

Faculty, Staff and Students Publications

Despite increasing prevalence of hypertension in youth and high adult cardiovascular mortality rates, the long-term consequences of youth-onset hypertension remain unknown. This is due to limitations of prior research, such as small sample sizes, reliance on manual record review, and limited analytic methods, that did not address major biases. The Study of the Epidemiology of Pediatric Hypertension (SUPERHERO) is a multisite, retrospective registry of youth evaluated by subspecialists for hypertension disorders. Sites obtain harmonized electronic health record data using standardized biomedical informatics scripts validated with randomized manual record review. Inclusion criteria are index visit for International Classification of Diseases, 10th …

Extreme Wrinkling Of The Nuclear Lamina Is A Morphological Marker Of Cancer, Ting-Ching Wang, Christina R Dollahon, Sneha Mishra, Hailee Patel, Samere Abolghasemzade, Ishita Singh, Vilmos Thomazy, Daniel G Rosen, Vlad C Sandulache, Saptarshi Chakraborty, Tanmay P Lele

Faculty, Staff and Students Publications

Nuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance. Whether this model is applicable to normal and cancer nuclei in human tissues is unclear. We image nuclear lamins in patient tissues and find: (a) nuclear laminar wrinkles are present in control and cancer tissue but are obscured in hematoxylin and eosin (H&E) images, (b) nuclei rarely have a smooth lamina, and (c) wrinkled nuclei assume diverse shapes. Deep learning reveals the presence …

Vps13b Is Localized At The Interface Between Golgi Cisternae And Is A Functional Partner Of Fam177a1, Berrak Ugur, Florian Schueder, Jimann Shin, Michael G Hanna, Yumei Wu, Marianna Leonzino, Maohan Su, Anthony R Mcadow, Catherine Wilson, John Postlethwait, Lilianna Solnica-Krezel, Joerg Bewersdorf, Pietro De Camilli

2020-Current year OA Pubs

Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between adjacent membranes, cause Cohen syndrome. VPS13B is known to be concentrated in the Golgi complex, but its precise location within this organelle and thus the site(s) where it achieves lipid transport remains unclear. Here, we show that VPS13B is localized at the interface between proximal and distal Golgi subcompartments and that Golgi complex reformation after Brefeldin A (BFA)-induced disruption is delayed in VPS13B KO cells. This delay is phenocopied by the loss of FAM177A1, a Golgi complex protein of unknown function reported to be a …

Major Depressive Disorder And Driving Behavior Among Older Adults, Ganesh M Babulal, Ling Chen, Jean-Francois Trani, David C Brown, David B Carr, Beau M Ances, Eric J Lenze, Drives Project

2020-Current year OA Pubs

IMPORTANCE: Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression.

OBJECTIVE: To examine differences in naturalistic driving behavior and safety between older adults with and without major depressive disorder (MDD).

DESIGN, SETTING, AND PARTICIPANTS: A prospective longitudinal cohort study was conducted among older adults (≥65 years) from the Driving Real-World In-Vehicle Evaluation System Project collected from July 1, 2021, to December 30, 2023. The sample included 85 participants with MDD and 310 participants without. Neurological, clinical, mood, and neuropsychological …

Heterozygous Btnl8 Variants In Individuals With Multisystem Inflammatory Syndrome In Children (Mis-C), Evangelos Bellos, Erica G Schmitt, Et Al.

2020-Current year OA Pubs

Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.2, 95% CI: 3.5-5.3, P < 10-6). BTNL8 encodes an intestinal epithelial regulator of Vγ4+γδ T cells implicated in regulating gut homeostasis. Enrichment was exclusive to MIS-C, being absent in patients with COVID-19 or bacterial disease. Using an available functional test for BTNL8, rare variants from a larger cohort of MIS-C patients (n = 835) were tested which identified eight variants in 18 patients (2.2%) with impaired engagement of Vγ4+γδ T cells. Most of these variants were in the B30.2 domain of BTNL8 implicated in sensing epithelial cell status. These findings were associated with altered intestinal permeability, suggesting a possible link between disrupted gut homeostasis and MIS-C-associated enteropathy triggered by SARS-CoV-2.

Artificial Intelligence (Ai)-Powered Bibliometric Analysis Of Global Trends In Mesenchymal Stem Cells (Mscs)-Derived Exosome Research: 2014-2023, Shih-Chang Tsai, Bing-Han Wan, Fuu-Jen Tsai, Jai-Sing Yang

BioMedicine

Introduction: In recent years, significant progress has been made in regenerative medicine, specifically in using mesenchymal stem cells (MSCs) due to their regenerative and differentiating abilities. An exciting development in this area is the utilization of exosomes derived from MSCs, which have shown promise in tissue restoration, immune system modulation, and cancer treatment.

Objectives: This study aims to analyze global research trends and the academic impact of MSCs-derived exosomes from 2014 to 2023, providing a comprehensive overview of this emerging field.

Materials and Methods: The Web of Science database selected 948 relevant publications from 2014 to 2023. Artificial intelligence …

Machine Learning-Guided Differential Gene Expression Analysis Identifies A Highly-Connected Seven-Gene Cluster In Triple-Negative Breast Cancer, Hany Ghazal, El-Sayed A. El-Absawy, Waleed Ead, Mohamed E. Hasan

BioMedicine

Background: One of the most challenging cancers is triple-negative breast cancer, which is subdivided into many molecular subtypes. Due to the high degree of heterogeneity, the role of precision medicine remains challenging. With the use of machine learning (ML)-guided gene selection, the differential gene expression analysis can be optimized, and eventually, the process of precision medicine can see great advancement through biomarker discovery.

Purpose: Enhancing precision medicine in the oncology field by identification of the most representative differentially-expressed genes to be used as biomarkers or as novel drug targets.

Methods: By utilizing data from the Gene Expression Omnibus (GEO) repository …

Integrating Natural Product Research Laboratory With Artificial Intelligence: Advancements And Breakthroughs In Traditional Medicine, Jai-Sing Yang, Shih-Chang Tsai, Yuan-Man Hsu, Da-Tian Bau, Chia-Wen Tsai, Wen-Shin Chang, Sheng-Chu Kuo, Sheng-Chu Kuo, Chien-Chih Yu, Yu-Jen Chiu, Fuu-Jen Tsai

BioMedicine

The Natural Product Research Laboratory (NPRL) of China Medical University Hospital (CMUH) was established in collaboration with CMUH and Professor Kuo-Hsiung Lee from the University of North Carolina at Chapel Hill. The laboratory collection features over 6,000 natural products worldwide, including pure compounds and semi-synthetic derivatives. This is the most comprehensive and fully operational natural product database in Taiwan. This review article explores the history and development of the NPRL of CMUH. We then provide an overview of the recent applications and impact of artificial intelligence (AI) in new drug discovery. Finally, we examine advanced powerful AI-tools and related software …

Transformative Interventions In Cell Biology: The Development And Use Of Instructor/Student-Interactive Demonstrations Of Key Cell Biology Concepts, Prashanth Rao, Ashok Upadhyaya, Meera Nanjundan

International Journal of Teaching and Learning in Higher Education

In Cell Biology, a sophomore/junior undergraduate-level high-enrollment core course, students are expected to develop a broad and detailed understanding of the functioning of eukaryotic cells. For example, some of the more challenging biological concepts include machinery involved in the replication and translational processes, protein trafficking/orientation in membranes, as well as both G protein-coupled receptor and receptor tyrosine kinase signal transduction pathways. In this instructional article, we describe prior published reports of the use of interactive demonstrations of several of these key biological concepts in the classroom. Furthermore, we narrate our efforts to integrate several of these disparate evidence-based techniques (EBTs) …

Flipped Teaching Eased The Transition To Online Learning Of College Students In Stem Courses During Covid-19, Sinan Onal, Carolyn Butts-Wilmsmeyer, Charles Serrano, Paige Dickey, Georgia Bracey, Sharon Locke, Julie Fickas, Chaya Gopalan

International Journal of Teaching and Learning in Higher Education

Following COVID-19, teaching was abruptly shifted from a live to a virtual format, posing a challenge to both students and faculty. There is a need to employ alternatives, emphasizing targeting the factors that suit Generation Z students for effective learning while maintaining social distancing. Understanding students' perceptions about the educational environment plays a vital role in planning and implementing teaching strategies for the future. Flipped teaching (FT) has been a successful instructional method because it embeds active learning strategies and some remote learning for which students are responsible. This study examined the perceptions of science, technology, engineering, and math (STEM) …

Efficacy Of Online Laboratory Exercises In Achieving Undergraduate Learning Outcomes In Introductory Astronomy Classes, Kristen Miller, Shelli Carter

International Journal of Teaching and Learning in Higher Education

Fully online courses and degree programs are popular with students today. It is important that these courses provide the same rigor and value of a traditional learning experience in a face-to-face classroom in order to ensure mastery of concepts and learning objectives. Online classes typically have suffered due to a lack of hands-on experiences for the students. One remedy to this is to include simulated hands-on work in the course through online laboratory exercises. The belief is that these simulated labs allow students to actively engage in the learning process, thus providing a traditional learning component in the online classroom. …

Building And Employing The Music-Coaching-Improv (M-C-I) Framework To Aid New Instructors In Overcoming The Imposter Phenomenon, John Hinck, Steven B. Davis, Andrew Clayton, Stephanie Wilson, Melanie Leon

International Journal of Teaching and Learning in Higher Education

New instructors often face feeling like an imposter. This article explains an innovative contribution called the Music-Coaching-Improv (M-C-I) Framework of 15 skills that includes the top five ways to use music, five key coaching skills, and five core improv skills. The M-C-I Framework was the foundation for three improv exercises that were selected due to their effectiveness in training the overlapping skills of active listening, support, letting go of judgment, being in the moment, cocreation, and acceptance that supported instructors overcoming the imposter phenomenon. This article examines how music, coaching, and improv training in an instructor development program influenced participants …

“It’S Like Listening To An Audiobook”: University Of Botswana Students’ Lived Experiences And Views About Online Learning During The Covid-19 Pandemic, Boitumelo Ramoroka, Keokgale Basetsana Tlhobogang, Brigid Goitse Conteh, Beauty Boikanyo Ntereke

International Journal of Teaching and Learning in Higher Education

The abrupt shift to online teaching and learning during the COVID-19 pandemic put a strain on the education sector the world over. Using the social constructivist theory, this study postulates that faceto- face teaching and learning does not seamlessly translate to online instruction both in terms of pedagogical practice and learner experiences. This study explores students’ experiences with the quality of online learning during the pandemic. Data were collected through focus group discussions with undergraduate students across seven faculties. A thematic analysis of the responses reveals that participants mostly reported negative experiences with online learning arising from factors such as …

Active Learning Classrooms Vs Computer Labs: Student Learning, Emotion, And Classroom Settings, Megumi Kuwabara

International Journal of Teaching and Learning in Higher Education

Using undergraduate students in the research methods course in Child Development as participants and keeping the instructional approach consistent, this study examined two research questions. The first research question tested the effect of two classroom settings, active learning classrooms (ALCs) versus computer labs, on students’ learning. The results found that students in ALCs performed marginally better than computer labs for overall course grades and papers, but not for exams. The second research question tested the relationship between the reduction of negative feeling state and learning and investigated whether the relationship differed based on the classroom setting (ALCs vs computer lab). …

Promoting Innovation Via A University-Organized Online Hackathon, Arnon Hershkovitz, Orly Lahav

International Journal of Teaching and Learning in Higher Education

This article presents a study of a full-day, university-organized, online hackathon that aimed at designing solutions to problems raised in remote learning and teaching. The event, with about 80 participants, was carried out during the COVID-19 pandemic when many schools were closed and shifted to emergency remote teaching. The hackathon participants were challenged to design innovative solutions to authentic problems that have been raised during this situation. Using an online questionnaire, to which 28 of the hackathon participants responded, we quantitatively and qualitatively examined how the event had affected them. Findings suggest that participating in the hackathon mostly contributed to …

Epistemological And Ontological Beliefs Of Educational Psychology Doctoral Students, Lia Daniels, Lauren Alston

International Journal of Teaching and Learning in Higher Education

As a discipline, educational psychology is somewhat idiosyncratic in terms of content and methodologies. Such idiosyncrasies are likely rooted in the philosophical history of the discipline which involves both the empirical tradition of Thorndike and the contextualized pragmatics of James and Dewey. Despite this, there is little teaching about epistemological and ontological beliefs in most educational psychology doctoral programs. The purpose of this research was to (a) describe educational psychology doctoral students’ epistemological and ontological beliefs and (b) determine the effectiveness of a four-part activity in supporting students’ learning about epistemology and ontology. This study represents scholarship of teaching and …

Promoting Innovation Via A University-Organized Online Hackathon, Arnon Hershkovitz, Orly Lahav

International Journal of Teaching and Learning in Higher Education

This article presents a study of a full-day, university-organized, online hackathon that aimed at designing solutions to problems raised in remote learning and teaching. The event, with about 80 participants, was carried out during the COVID-19 pandemic when many schools were closed and shifted to emergency remote teaching. The hackathon participants were challenged to design innovative solutions to authentic problems that have been raised during this situation. Using an online questionnaire, to which 28 of the hackathon participants responded, we quantitatively and qualitatively examined how the event had affected them. Findings suggest that participating in the hackathon mostly contributed to …

Aligning Artificial Intelligence With Climate Change Adaptation In Egypt, Lara Mohamed Abdelrazik Ms.

Future Journal of Social Science

Abstract:

One of the frequently witnessed barriers to accelerating action on climate change is related to the construction of data bases, variables, and models as well as data extraction. According to the Grantham Research Institute on climate change and the environment, several subfields of Artificial Intelligence identify patterns to support the completion of specific tasks towards combating climate change such as; gathering, completing, and interpreting large, and complete datasets by making it possible to enhance data-driven decision-making for climate action. However, the negative side of AI was also recognized.

Learning algorithms to understand how AI’s climate impact goes beyond its …

Examining The Relationship Between Textbook Formats, Students’ Self-Efficacy And Academic Performance In Higher Education, Anthony Eya

Dissertations

Ideally, educators would have sufficient data to understand how textbook formats (Ebook and Pbook) can transform negative student behaviors resulting from low self-efficacy to improve their academic performance (Alegre, 2014; Masa’deh et al., 2022). The problem driving this study is the lack of empirical data on the relationship between textbook format, student self-efficacy, academic performance, and behavioral factors that undermine student success in a self-regulated learning environment (Masa’deh et al., 2022). Also, there is a need for data that could inform strategies for solutions to poor student self-efficacy regarding textbook type and low academic performance (Alegre, 2014). This study used …

High-Severity Wildfires Alter Ant (Hymenoptera: Formicidae) Foraging Assemblage Structure In Montane Coniferous Forests And Grasslands In The Jemez Mountains, New Mexico, Usa, Jonathan Knudsen, Robert Parmenter, Theodore Sumnicht, Robin M. Verble

Biological Sciences Faculty Research & Creative Works

High-severity wildfires create heterogeneous patterns of vegetation across burned landscapes. While these spatial patterns are well-documented, less is known about the short- and long-term effects of large-scale high-severity wildfires on insect community assemblages and dynamics. Ants are bottom-up indicators of ecosystem health and function that are sensitive to disturbance and fill a variety of roles in their ecosystems, including altering soil chemistry, dispersing seeds, and serving as a key food resource for many species, including the federally endangered Jemez Mountain salamander (Plethodon neomexicanus). We examined the post-fire effects of the 2011 Las Conchas Wildfire on ant communities in the Valles …

Analyzing The Efficacy Of Dupilumab On Skin Clearance In Pediatric Patients With Atopic Dermatitis, Naomy Procopoi, Jason Brumitt

Doctor of Medical Science (DMSc)

Severe atopic dermatitis significantly impairs the quality of life for infants and young children, along with their family members and caregivers. Atopic dermatitis is a chronic inflammatory disease of the skin. It is characterized by pruritic, erythematous, and xerotic skin. The prevalence of atopic dermatitis in the pediatric population is much greater than in adults; it is estimated that approximately 15-20% of children worldwide are affected by this condition. Although the majority of these children achieve spontaneous remission in adulthood, mild to moderate disease may often be debilitating and lead to a lower quality of life.

Previously, the only approved …

Re: Proteomic Exploration Of Potential Blood Biomarkers In Haemophilic Arthropathy, Quang D La, David F Lo, Don D Shamilov

Rowan-Virtua School of Osteopathic Medicine Departmental Research

We wish to convey our reflections on the scholarly article titled “Proteomic exploration of potential blood biomarkers in haemophilic arthropathy” [1]. This investigation elucidates significant results concerning the plasma proteome of individuals afflicted with hemophilic arthropathy (HA) across a spectrum of severities, accentuating pivotal variations in protein expression correlated with disease severity and emphasizing the intricate nature of HA pathophysiology.

Going With The Flow: How Direct And Indirect Alterations To Streamflow Influence Headwater Fish Communities In The Southeast, Langston Haden

Dissertations

Streamflow has been deemed the “master variable” regulating riverine communities as it can influence the chemical, physical, and biological components of river systems. Anthropogenic changes have and will continue to alter streamflow through direct (e.g. road culverts) and indirect (e.g. climate change) processes. Understanding how these alterations impact riverine communities is essential for maintaining and restoring ecosystem properties like biodiversity. Our objective is to integrate ecological theory and conservation approaches to understand how direct and indirect alterations to streamflow influence freshwater fish communities within the biodiverse headwater streams of the southeastern U.S. In a test of a standardized barrier protocol …

2024 December, Cleveland State University College Of Law

2020s

No abstract provided.

Reaction Of A Chiral Platinum Triamine Compound With Key Amino Acid And Guanine Analog, Onu Emmanuel Chukwu

Masters Theses & Specialist Projects

Platinum compounds can exhibit cytotoxic activity through reaction with DNA; however, interaction with proteins and DNA bases, especially with methionine residues and Guanine analogs, is another common biological reaction. Our lab has synthesized Chloro[2-(4-Methyl-1,4- diazepan-1-yl) ethanamine]platinum(II) chloride ([Pt(L)Cl]Cl), which has a tridentate binding mode for the amine ligand. This study focused on the reaction of the chiral platinum triamine with key amino acids (methionine and 2-hydroxybutyric acid) and guanine analogs under different pH and temperature conditions. The mass spectrometry of N-AcMet Interaction with [Pt(L)Cl]+ showed a m/z of 542 and 579 for reactions at pH 4. The m/z of 542 …

Aquila And Predator: The Failure And Momentum Of Drone Technologies In The U.S., 1970-2015, Michael Rasak

Masters Theses & Specialist Projects

This article examines the technological and intellectual histories of unmanned aircraft systems (UAS) development in the U.S. from the 1970s until 2015. Borrowing from the field of science and technology studies, the author argues that although early drone development demonstrated a significant degree of heterogeneity (i.e., interpretive flexibility), the spectacular failure in 1987 of one program in particular—the Aquila Remotely Piloted Vehicle—thereafter contributed to a significant restricting of UAS potentialities. Aquila’s demise prompted a Congressional directive in 1988 to consolidate the disparate UAS development efforts within the U.S. Department of Defense (DoD) under one joint program, ushering in a means …

Exploring The Relationship Between Adverse Childhood Experiences (Aces) And Social Determinants Of Health (Sd0h), Amiyah Thomas, Drew Buggs

MSW Capstone Conference

No abstract provided.