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2024

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Role Of Vitamin E And Vitamin A On Severity Of Oral Mucositis Caused By Chemotherapy - A Randomized Double-Blind Cross-Over Clinical Trial, Hossein Gholami, Tahereh Ahrari Roodi, Mohamad Amir Mohamadifard, Leili Alizadeh Dec 2024

Role Of Vitamin E And Vitamin A On Severity Of Oral Mucositis Caused By Chemotherapy - A Randomized Double-Blind Cross-Over Clinical Trial, Hossein Gholami, Tahereh Ahrari Roodi, Mohamad Amir Mohamadifard, Leili Alizadeh

Journal of Dentistry Indonesia

Objective: This study aimed to evaluate the efficacy of these vitamins in reducing chemotherapy-induced oral mucositis through a randomized, double-blind, cross-over clinical trial. Methods: This study involved 20 participants, primarily female (70%), with an average age of 52.2 years. Participants first received oral vitamin E and A with chemotherapy, followed by a placebo. The severity of mucositis and pain responses were assessed at the start of the study and at 7-, 14-, and 21-day post-treatment initiation. Data analysis was performed using SPSS software with a significance level of 0.05. Results: Twenty patients,14 (70%) females, with a mean …


Treatment Of Odontogenic Cysts Using A Minimally Invasive Approach: A Case Series From Vietnam, Minh Hang Luong, Vo Truong Nhu Ngoc, Tien Dat Cung, Hau Bau Tran, Quang Minh Luu, Huu Huynh Nguyen, Thao Phuong Tran Dec 2024

Treatment Of Odontogenic Cysts Using A Minimally Invasive Approach: A Case Series From Vietnam, Minh Hang Luong, Vo Truong Nhu Ngoc, Tien Dat Cung, Hau Bau Tran, Quang Minh Luu, Huu Huynh Nguyen, Thao Phuong Tran

Journal of Dentistry Indonesia

This study aims to evaluate the effectiveness of decompression as a treatment approach for radicular cysts in five pediatric patients. Case report: 5 pediatric patients with five cystic lesions from 6 to 11 years old diagnosed with radicular cysts were treated by decompression. Clinical and radiograph data from pre- and post-surgery were collected and analyzed. Complete resolution of all cystic lesions and simultaneous eruption of impacted teeth within the cyst were managed. The mean follow-up time is 25.6 months, and no recurrences were observed. Conclusion: Decompression should be considered a preferred treatment for cystic lesions in children, as it has …


Directed Evolution Of Hedgehog Protein Autoprocessing Activity: Combined Experimental & Computational Approach, Ted Kuke Dec 2024

Directed Evolution Of Hedgehog Protein Autoprocessing Activity: Combined Experimental & Computational Approach, Ted Kuke

Undergraduate Honors Theses

Sonic hedgehog protein is vital for embryonic development while also being linked to multiple cancers and holoprosencephaly. The native reaction of hedgehog is a sterolysis reaction whereby cholesterol binds to the HhC catalytic domain and attacks the HhN signaling domain, resulting in a covalent HhN-cholesterol signaling product. The structure of the sterol recognition region (SRR) of Sonic Hedgehog, where cholesterol binds, is currently unknown. In this thesis, I used directed evolution to select a triple mutant of Hedgehog’s catalytic HhC domain, (D46H, Q150H, A196T), which is over 5000 times more catalytically efficient at reacting with epicoprostanol (ECP), a non-native substrate …


Understanding The Transitional Needs Of Servicemembers To Veterans: A Focus On Mental, Social, And Behavioral Health, Marieann C. Raguso Dec 2024

Understanding The Transitional Needs Of Servicemembers To Veterans: A Focus On Mental, Social, And Behavioral Health, Marieann C. Raguso

Theses and Dissertations

This applied dissertation was designed to fill the gaps on the transitional American veterans’ lived experience using their own voice. The reconstruction of an American Veteran’s identity after transitioning back into civilian life is a process with many challenges. Transitional practices often fail to help veterans to acculturate back into the civilian world. This includes the formulation of identities and associations. There is a lack of consistency in military transitional practices leading to identity loss and the formulation of mental and behavioral disorders. The aim of this study is to examine the lived experiences of veterans who have transitioned back …


Honeybee Biodiversity Based On Five Mitochondrial Genes And New Evidence For Differentsublineages In Türkiye, Meral Kekeçoğlu, Songül Bi̇r, Merve Kambur Acar, Rustem Ilyasov Dec 2024

Honeybee Biodiversity Based On Five Mitochondrial Genes And New Evidence For Differentsublineages In Türkiye, Meral Kekeçoğlu, Songül Bi̇r, Merve Kambur Acar, Rustem Ilyasov

Turkish Journal of Veterinary & Animal Sciences

In this study, the genetic structure of honey bee populations in Türkiye was analyzed using eleven restriction endonuclease enzymes targeting the COI-COII, COI, 16S rDNA, ND5, and CYT B genes. A total of 553 worker honey bee samples were collected from 43 different districts across Türkiye, as well as from Greece, Bulgaria, and Georgia, neighboring countries of Türkiye. Analysis of the COI region using the HinfI restriction enzyme revealed the presence of two mitotypes. Type 1 was the predominant type in Türkiye, while Type 2 was detected exclusively in Hatay, a province in the southern part of the country. Notably, …


Phenotypic And Molecular Characterization And Antimicrobial Susceptibility Pattern Of Pasteurella And Mannheimia Species Obtained From Cattle And Sheep With Pneumonia, Eli̇f Karadeni̇z Pütür, Fati̇h Büyük, Yaren Ersoy Dec 2024

Phenotypic And Molecular Characterization And Antimicrobial Susceptibility Pattern Of Pasteurella And Mannheimia Species Obtained From Cattle And Sheep With Pneumonia, Eli̇f Karadeni̇z Pütür, Fati̇h Büyük, Yaren Ersoy

Turkish Journal of Veterinary & Animal Sciences

Among the heterogeneous Pasteurellaceae family, Pasteurella multocida and Mannheimia haemolytica are the pathogenic species that cause enzootic pneumonia in cattle and sheep. This study aimed to characterise Pasteurella and Mannheimia species obtained from pneumonia cases in cattle and sheep. 100 cattle and 100 sheep lungs diagnosed with infectious pneumonia as a result of histopathological examination were analyzed for Pasteurellaceae members by phenotypic methods, VITEK 2 Compact system and PCR. Antibiotic susceptibilities and phylogenetic analysis of the isolates were done by VITEK 2 Compact System and 16S rRNA-PCR, respectively. Seven Pasteurella multocida and 9 Mannheimia haemolytica were identified. All strains were …


Nanotechnology And Nonmaterial Applications In Oil Industries In Recent Years: A Review, Fatma Ehssan, Tabarak Haider, Thamer A. Abdullah, Mustafa Hathal, Viola Somogyi, Khalida Al-Azawi Dec 2024

Nanotechnology And Nonmaterial Applications In Oil Industries In Recent Years: A Review, Fatma Ehssan, Tabarak Haider, Thamer A. Abdullah, Mustafa Hathal, Viola Somogyi, Khalida Al-Azawi

Journal of Applied Sciences and Nanotechnology

Several disciplines recognize nanotechnology's revolutionary potential, including nanoelectronics, nanobiomedicine, and nanodevices. Surprisingly, the oil and gas industry's upstream exploration and production sector has shown limited enthusiasm. Increased oil recovery and the use of unconventional resources are vital for success, but recessions, particularly during low crude oil prices in the 19th century, pose additional challenges. In response, significant attention has turned to applying nanotechnology to overcome these industrial barriers. Recently, government agencies and the global oil sector have boosted investments in exploration, drilling, production, treatment, and wastewater management. Notably, nanosensors provide precise reservoir monitoring, while nanofluids with advanced nanoparticles significantly enhance …


Micrornas: Where Brilliance, Perseverance, And Ambition Converged, Rares Drula, George A Calin Dec 2024

Micrornas: Where Brilliance, Perseverance, And Ambition Converged, Rares Drula, George A Calin

Faculty, Staff and Student Publications

Victor Ambros at the University of Massachusetts Medical School and Gary Ruvkun at Harvard University were awarded the 2024 Nobel Prize in Medicine and Physiology for the discovery of microRNAs. This “groundbreaking discovery revealed a completely new principle of gene regulation that turned out to be essential for multicellular organisms, including humans” (1). This is a well-deserved and highly anticipated recognition for a seminal discovery published 31 years ago in back-to-back Cell publications (2, 3). This landmark finding changed the way we understand gene expression regulation among most multicellular organisms (4) and had …


An Empirical Model Of Carbon-Ion Relative Biological Effectiveness Based On The Linear Correlation Between Radiosensitivity To Photons And Carbon Ions, David B Flint, Scott J Bright, Conor Mcfadden, Teruaki Konishi, David K J Martinus, Mandira Manandhar, Mariam Ben Kacem, Lawrence Bronk, Gabriel O Sawakuchi Dec 2024

An Empirical Model Of Carbon-Ion Relative Biological Effectiveness Based On The Linear Correlation Between Radiosensitivity To Photons And Carbon Ions, David B Flint, Scott J Bright, Conor Mcfadden, Teruaki Konishi, David K J Martinus, Mandira Manandhar, Mariam Ben Kacem, Lawrence Bronk, Gabriel O Sawakuchi

Faculty, Staff and Student Publications

Objective.To develop an empirical model to predict carbon ion (C-ion) relative biological effectiveness (RBE).Approach.We used published cell survival data comprising 360 cell line/energy combinations to characterize the linear energy transfer (LET) dependence of cell radiosensitivity parameters describing the dose required to achieve a given survival level, e.g. 5% (D5%), which are linearly correlated between photon and C-ion radiations. Based on the LET response of the metrics D5%and D37%, we constructed a model containing four free parameters that predicts cells' linear quadratic model (LQM) survival curve parameters for C-ions,αCandβC, from the reference LQM parameters …


Current Status And The Significance Of Local Wisdom Biofertilizer In Enhancing Soil Health And Crop Productivity For Sustainable Agriculture: A Systematic Literature Review, Irwandhi, Fiqriah Hanum Khumairah, Emma Trinurani Sofyan, Nadia Nuraniya Kamaluddin, Anne Nurbaity, Diyan Herdiyantoro, Tualar Simarmata Dec 2024

Current Status And The Significance Of Local Wisdom Biofertilizer In Enhancing Soil Health And Crop Productivity For Sustainable Agriculture: A Systematic Literature Review, Irwandhi, Fiqriah Hanum Khumairah, Emma Trinurani Sofyan, Nadia Nuraniya Kamaluddin, Anne Nurbaity, Diyan Herdiyantoro, Tualar Simarmata

Jurnal Kultivasi

Soil fertility is recognized as a crucial factor in supporting plant growth and productivity. The utilization of biofertilizers as environmentally friendly fertilizers is aimed at enhancing soil fertility and plant productivity. This study aims to explore the potential of local material for developing local wisdom biofertilizers (LWB) for achieving sustainable agriculture. A systematic literature review was conducted using bibliometric analysis, Preferred Reporting Items for Systematic Reviews, and Meta-Analyses (PRISMA) method, employing the Scopus search engine with the keywords "local AND wisdom AND biofertilizer" OR "biofertilizer" OR "local AND microorganism" OR "soil AND health OR crop AND productivity OR sustainable agriculture". …


Carbon Stocks In Marine Habitats Across Jersey's Territorial Waters, Bede Ffinian Rowe Davies, Samantha Blampied, Francis Binney, Graham Epstein, Paul Chambers, Emma V. Sheehan Dec 2024

Carbon Stocks In Marine Habitats Across Jersey's Territorial Waters, Bede Ffinian Rowe Davies, Samantha Blampied, Francis Binney, Graham Epstein, Paul Chambers, Emma V. Sheehan

School of Biological and Marine Sciences

Marine areas have been shown to store varying amounts of carbon. The densities of these stores varies considerably across environmental settings, including the biotic and physical habitat type, the productivity of these habitats, the ephemeral or permanent nature of the habitats as well as the hydrological energy of the area, its depth and its exposure to anthropogenic activities. To appropriately incorporate carbon storage into management plans, baseline information on the carbon held within marine areas is required. Here, an inventory of carbon was carried out for marine habitats found within the territorial waters of Jersey, one of the Channel Islands …


Simple Improvements In Vector Design Afford Substantial Gains In Aav Delivery Of Aggregation-Slowing Aβ Variants, Ella Borgenheimer, Cameron Trueblood, Bryan L Nguyen, William R Lagor, Joanna L Jankowsky Dec 2024

Simple Improvements In Vector Design Afford Substantial Gains In Aav Delivery Of Aggregation-Slowing Aβ Variants, Ella Borgenheimer, Cameron Trueblood, Bryan L Nguyen, William R Lagor, Joanna L Jankowsky

Faculty, Staff and Students Publications

Adeno-associated virus (AAV) gene therapy for neurological disease has gained traction due to stunning advances in capsid evolution for CNS targeting. With AAV brain delivery now in focus, conventional improvements in viral expression vectors offer a complementary route for optimizing gene delivery. We previously introduced a novel AAV gene therapy to slow amyloid aggregation in the brain based on neuronal release of an Aβ sequence variant that inhibited fibrilization of wild-type Aβ. Here we explore three coding elements of the virally delivered DNA plasmid in an effort to maximize the production of therapeutic peptide in the brain. We demonstrate that …


A Rare Case Of A Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance And A Review Of Literature, Mokhtar H Abdelhammed, Hanna Siatecka, A Hafeez Diwan, Christie J Finch, Angela D Haskins, David J Hernandez, Ya Xu Dec 2024

A Rare Case Of A Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance And A Review Of Literature, Mokhtar H Abdelhammed, Hanna Siatecka, A Hafeez Diwan, Christie J Finch, Angela D Haskins, David J Hernandez, Ya Xu

Faculty, Staff and Students Publications

Malignant proliferating trichilemmal tumors (MPTTs), arising from the external root sheath of hair follicles, are exceptionally rare, with limited documentation of their genetic alterations. We present a case of a 64-year-old African American woman who initially presented with a gradually enlarging nodule on her posterior scalp. An initial biopsy at an outside hospital suggested metastatic adenocarcinoma or squamous cell carcinoma (SCC) of an uncertain origin. A subsequent wide local excision revealed a 2.0 cm tumor demonstrating characteristic trichilemmal keratinization, characterized by an abrupt transition from the nucleated epithelium to a laminated keratinized layer, confirming MPTT. Immunohistochemistry demonstrated diffuse p53 expression, …


Imlunestrant, An Oral Selective Estrogen Receptor Degrader, As Monotherapy And In Combination With Targeted Therapy In Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Phase Ia/Ib Ember Study, Komal L Jhaveri, Cynthia X Ma, Et Al. Dec 2024

Imlunestrant, An Oral Selective Estrogen Receptor Degrader, As Monotherapy And In Combination With Targeted Therapy In Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Phase Ia/Ib Ember Study, Komal L Jhaveri, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

PURPOSE: Imlunestrant is a next-generation oral selective estrogen receptor (ER) degrader designed to deliver continuous ER target inhibition, including in

METHODS: An i3+3 dose-escalation design was used, followed by dose expansions of imlunestrant as monotherapy or in combination with abemaciclib with or without aromatase inhibitor (AI), everolimus, or alpelisib. Imlunestrant was administered orally once daily and with the combination partner per label.

RESULTS: Overall, 262 patients with ER+/HER2- ABC were treated (phase Ia, n = 74; phase Ib, n = 188). Among patients who received imlunestrant monotherapy (n = 114), no dose-limiting toxicities or discontinuations occurred. At the RP2D (400 …


Prenatal Social Disadvantage Is Associated With Alterations In Functional Networks At Birth, Ashley N Nielsen, Regina L Triplett, Lourdes M Bernardez, Ursula A Tooley, Max P Herzberg, Rachel E Lean, Sydney Kaplan, Dominique Meyer, Jeanette K Kenley, Dimitrios Alexopoulos, David Losielle, Aidan Latham, Tara A Smyser, Arpana Agrawal, Josh S Shimony, Joshua J Jackson, J Philip Miller, Marcus E Raichle, Barbara B Warner, Cynthia E Rogers, Chad M Sylvester, Deanna M Barch, Joan L Luby, Christopher D Smyser Dec 2024

Prenatal Social Disadvantage Is Associated With Alterations In Functional Networks At Birth, Ashley N Nielsen, Regina L Triplett, Lourdes M Bernardez, Ursula A Tooley, Max P Herzberg, Rachel E Lean, Sydney Kaplan, Dominique Meyer, Jeanette K Kenley, Dimitrios Alexopoulos, David Losielle, Aidan Latham, Tara A Smyser, Arpana Agrawal, Josh S Shimony, Joshua J Jackson, J Philip Miller, Marcus E Raichle, Barbara B Warner, Cynthia E Rogers, Chad M Sylvester, Deanna M Barch, Joan L Luby, Christopher D Smyser

2020-Current year OA Pubs

Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that contribute to risk trajectories. Yet, given the limited social mobility in the United States and other countries, childhood social disadvantage is frequently preceded by maternal social disadvantage during pregnancy, potentially altering fetal brain development during a period of high neuroplasticity through hormonal, microbiome, epigenetic, and immune factors that cross the placenta and fetal blood-brain barrier. The current study examines prenatal social disadvantage to determine whether these exposures in utero are associated …


Impact Of Prior Inotuzumab Ozogamicin Treatment On Brexucabtagene Autoleucel Outcomes In Adults With B-Cell All, Ibrahim Aldoss, Gregory W Roloff, Rawan Faramand, Noam E Kopmar, Chenyu Lin, Anjali S Advani, Simone E Dekker, Vishal K Gupta, Timothy E O'Connor, Nikeshan Jeyakumar, Ibrahim N Muhsen, Yannis Valtis, Amy Zhang, Katharine Miller, Katherine Sutherland, Kaitlyn C Dykes, Mohamed Ahmed, Evan Chen, Hector Zambrano, Danielle Bradshaw, Santiago Mercadal, Marc Schwartz, Sean Tracy, Bhagirathbhai Dholaria, Michal Kubiak, Akash Mukherjee, Navneet Majhail, Minoo Battiwalla, Luke Mountjoy, Shahbaz A Malik, John Mathews, Paul Shaughnessy, Aaron C Logan, Abdullah Ladha, Maryann Stefan, Caitlin Guzowski, Rasmus T Hoeg, Talal Hilal, Jozal Moore, Matthew Connor, Kristen M O'Dwyer, Laquisa C Hill, Stephanie B Tsai, Joshua Sasine, Melhem M Solh, Catherine J Lee, Vamsi K Kota, Divya Koura, Muthu Veeraputhiran, Betsy Blunk, Caspian Oliai, Jessica T Leonard, Noelle V Frey, Jae H Park, Marlise R Luskin, Veronika Bachanova, Ahmed Galal, Michael R Bishop, Wendy Stock, Ryan D Cassaday, Vinod Pullarkat, Bijal D Shah, Lori S Muffly Dec 2024

Impact Of Prior Inotuzumab Ozogamicin Treatment On Brexucabtagene Autoleucel Outcomes In Adults With B-Cell All, Ibrahim Aldoss, Gregory W Roloff, Rawan Faramand, Noam E Kopmar, Chenyu Lin, Anjali S Advani, Simone E Dekker, Vishal K Gupta, Timothy E O'Connor, Nikeshan Jeyakumar, Ibrahim N Muhsen, Yannis Valtis, Amy Zhang, Katharine Miller, Katherine Sutherland, Kaitlyn C Dykes, Mohamed Ahmed, Evan Chen, Hector Zambrano, Danielle Bradshaw, Santiago Mercadal, Marc Schwartz, Sean Tracy, Bhagirathbhai Dholaria, Michal Kubiak, Akash Mukherjee, Navneet Majhail, Minoo Battiwalla, Luke Mountjoy, Shahbaz A Malik, John Mathews, Paul Shaughnessy, Aaron C Logan, Abdullah Ladha, Maryann Stefan, Caitlin Guzowski, Rasmus T Hoeg, Talal Hilal, Jozal Moore, Matthew Connor, Kristen M O'Dwyer, Laquisa C Hill, Stephanie B Tsai, Joshua Sasine, Melhem M Solh, Catherine J Lee, Vamsi K Kota, Divya Koura, Muthu Veeraputhiran, Betsy Blunk, Caspian Oliai, Jessica T Leonard, Noelle V Frey, Jae H Park, Marlise R Luskin, Veronika Bachanova, Ahmed Galal, Michael R Bishop, Wendy Stock, Ryan D Cassaday, Vinod Pullarkat, Bijal D Shah, Lori S Muffly

Faculty, Staff and Students Publications

The effect of prior inotuzumab ozogamicin (InO) treatment on brexucabtagene autoleucel (brexu-cel) outcomes remains unclear in adults with acute lymphoblastic leukemia (ALL). We conducted a retrospective multicenter analysis of 189 patients with relapsed/refractory ALL treated with brexu-cel. Over half of the patients received InO before brexu-cel (InO exposed). InO-exposed patients were more heavily pretreated (P = .02) and frequently had active marrow disease before apheresis (P = .03). Response rate and toxicity profile after brexu-cel were comparable for InO-exposed and InO-naïve patients; however, consolidation therapy after brexu-cel response was used at a higher rate in InO-naïve patients (P = .005). …


Oligosaccharides, Onion Peel, And Essential Oils As Feed Additives In The Diet Of Dairycattle: In Vitro Fermentation, Greenhouse Gases, Ruminal Nutrient Degradability, Andvolatile Fatty Acid Production, Kelechi A. Ike, Oludotun O. Adelusi, Joel O. Alabi, Lydia K. Olagunju, Michael Wuaku, Chika C. Anotaenwere, Deborah O. Okedoyin, Oluteru E. Orimaye, Deandrea Gray, Peter A. Dele, Kiran Subedi, Ahmed E. Kholif, Uchenna Y. Anele Dec 2024

Oligosaccharides, Onion Peel, And Essential Oils As Feed Additives In The Diet Of Dairycattle: In Vitro Fermentation, Greenhouse Gases, Ruminal Nutrient Degradability, Andvolatile Fatty Acid Production, Kelechi A. Ike, Oludotun O. Adelusi, Joel O. Alabi, Lydia K. Olagunju, Michael Wuaku, Chika C. Anotaenwere, Deborah O. Okedoyin, Oluteru E. Orimaye, Deandrea Gray, Peter A. Dele, Kiran Subedi, Ahmed E. Kholif, Uchenna Y. Anele

Turkish Journal of Veterinary & Animal Sciences

This study investigated the effect of inclusion of dietary oligosaccharides, onion peel, and an essential oil blend (EOB; containing anise, clove, oregano, cedarwood, and ginger in the ratio 4:2:2:1:1) individually and in combinations in the total mixed ration of dairy cattle on in vitro gas production (GP), dry matter disappearance (DMD), fiber fraction disappearance, and total and individual volatile fatty acid (VFA) production. EOB was used at 200 μL g–1 of feed while the other additives were administered at 3% of the feed on a dry matter basis. The in vitro batch culture technique was used for this experiment and …


Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan Dec 2024

Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan

Turkish Journal of Medical Sciences

Background/aim: Mucinous breast carcinoma (MC) is thought to be a favorable-differentiated form of invasive breast cancer and is rarely preferred for neoadjuvant chemotherapy (NAC). The study aimed to define the response of MCs to NAC.Materials and methods: The study reviewed the demographic, clinicopathologic characteristics, management, and follow-up data of 70 patients diagnosed with MC between May 2010 to December 2020 by examining patients’ historical files and oncology records.Results: The median age, tumor size, and follow-up period of patients were respectively 52.9 (range 32 to 87) years, 25.8 (range 8 to 88) mm, and 61.5 (range 18 to 143) months. Out …


The Relationship Between Drug Induced Immunogenicity And Hypersensitivity Reactions And Skin Tests Related To Infliximab, Etanercept And Adalimumab In Patients With Rheumatoid Arthritis And Ankylosing Spondylitis, Alper Doğanci, Şebnem Ataman, Ali̇ Özdemi̇rel, Recep Seçki̇n, Ayşe Yalçin, Sevi̇m Bavbek Dec 2024

The Relationship Between Drug Induced Immunogenicity And Hypersensitivity Reactions And Skin Tests Related To Infliximab, Etanercept And Adalimumab In Patients With Rheumatoid Arthritis And Ankylosing Spondylitis, Alper Doğanci, Şebnem Ataman, Ali̇ Özdemi̇rel, Recep Seçki̇n, Ayşe Yalçin, Sevi̇m Bavbek

Turkish Journal of Medical Sciences

Background and aim: We aimed to investigate the relationship between serum anti-drug antibody (ADAb), hypersensitivity reactions (HSRs) to anti-tumor necrosis factors (anti-TNFs) drugs and to detect the role of skin tests in the diagnosis of HSRs against anti-TNFs.Material and methods: 69 ankylosing spondilitis (AS) and 46 rheumatoid artritis (RA) patients using infliximab, adalimumab, and etanercept were enrolled. Disease activity scores for AS and RA patients were assessed. Serum levels of anti-TNFs and ADAb to these agents were measured with the ELISA.These blood samples were taken 24 hours before the next drug dose.The patients with anti-TNF-associated HSRs were evaluated with a …


High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz Dec 2024

High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz

Turkish Journal of Medical Sciences

Background/aim: Syndesmophyte formation appears to be site specific in Ankylosing spondylitis(AS),and new bone formation seems to occur in regions of micro-trauma that are prone to tensile forces.Pelvic and spinal parameters are unique for individuals. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance. After puberty, the sacral slope shapes the lumbar lordosis, whereas the pelvic incidence is set to an individual constant. This study aims to analyze the properties of pelvic parameters in AS patients with and without syndesmophyte formation in the spine after 15years of disease duration.Materials and methods:Whole spine …


Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz Dec 2024

Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz

Turkish Journal of Medical Sciences

Background/aim:Menopause is often accompanied by neurological symptoms, including cognitive difficulties, especially with memory and attention. In the present study, the purpose was to examine the relationship between the timing of menopause and the cognitive performance of menopausal patients who applied to our neurology clinic with complaints of forgetfulness.Materials and methods: The data of 538 women who applied to the neurology clinic with complaints of forgetfulness between January 2018 and January 2024and underwent neuropsychological evaluations were scanned retrospectively. A total of 96 patients who applied to neurology and menopause clinics were included in the study.Results: In the present study, attention orientation, …


Happiness At Work – How Workplace Spirituality Contributes To Employee Wellbeing, Amarendra Nath Misra, Mohammad Israrul Haque, Gaurav Tripathi Dec 2024

Happiness At Work – How Workplace Spirituality Contributes To Employee Wellbeing, Amarendra Nath Misra, Mohammad Israrul Haque, Gaurav Tripathi

Management Dynamics

Workplace spirituality is associated with employees looking for meaning, self-transcendence, inclusion, values, ethics, and protection of one's religious beliefs. The study aimed to review literature about Spirituality in the workplace and employee wellbeing, find definitions of both constructs and enumerate studies that have shown the connection between the two constructs. The findings of the research paper suggest a strong connection between the workplace and employee wellbeing, which benefits employees, enhances organisational performance, and improves employee wellbeing and, thereby, the quality of their lives. The paper introduces workplace spirituality, provides a sense of purpose and meaning at work, and suggests that …


Transgender And Gender-Queer People Belong In Jesuit Higher Education, Morgan Keating, Konstantin Platonov Dec 2024

Transgender And Gender-Queer People Belong In Jesuit Higher Education, Morgan Keating, Konstantin Platonov

Jesuit Higher Education: A Journal

This paper explores the intersection of Jesuit values and the experiences of transgender and gender-queer campus community members in Jesuit higher education institutions. Despite the adoption of inclusive policies, campus climates often lack the support of minorities, leading to discrimination and deterioration of their mental health. The core Jesuit values—cura personalis, magis, discernment and reflection, service rooted in justice and love, and solidarity and kinship—are examined as the principles that should drive more active inclusion and support. The paper also suggests practical steps to align institutional practices with these values better. By embracing these measures, …


Course Registration Practices At A Jesuit University: Practicing Critical Hope To Address Barriers To Access And Belonging, Corey Knadler, Laura Diaz Martinez, Annmarie Caño, Kirk R. Anders, Yolanda Gallardo, Nancy L. Staub Dec 2024

Course Registration Practices At A Jesuit University: Practicing Critical Hope To Address Barriers To Access And Belonging, Corey Knadler, Laura Diaz Martinez, Annmarie Caño, Kirk R. Anders, Yolanda Gallardo, Nancy L. Staub

Jesuit Higher Education: A Journal

Solidarity and critical hope support faculty and staff who wish to accompany students, read the current reality of their experience, and imagine new practices that can rectify injustices and promote access and belonging. Here, we describe an example of this praxis by responding to student concerns about injustices in a course registration process. With some exceptions, undergraduates at this institution register for classes according to their earned college credits. At first glance, this meritocratic system shows care to students by recognizing their hard work. However, our analysis shows that it also discriminates against underserved groups of students. Using 10 years …


Teaching Ettingerian Matrixial Theory, R. Michael Fisher Dec 2024

Teaching Ettingerian Matrixial Theory, R. Michael Fisher

Artizein: Arts and Teaching Journal

Utilizing an adapted scoping review of the literature on Bracha L. Ettinger and Education (2008-2024), the author reveals the specific ways that Ettingerian Matrixial Theory (EMT) and its pedagogies are taught and can be taught in the future. EMT is argued to be a new branch of Critical Theory. The current literature shows there is mostly engagement with EMT in academic settings. As well, the literature reviewed shows EMT is used readily in arts and with artists as teachers and teachings for adults. However, the author unveils diverse other possibilities of teaching EMT. A few major themes from the literature …


Her (Ettinger’S) Diotima, His (Levinas’) Diotima: On The Vitalness Of Eros In Education, Shiran Greenberg Dec 2024

Her (Ettinger’S) Diotima, His (Levinas’) Diotima: On The Vitalness Of Eros In Education, Shiran Greenberg

Artizein: Arts and Teaching Journal

No abstract provided.


Examining The Role Of Teacher Beliefs In Evolution Education, Tyler Bayes Dec 2024

Examining The Role Of Teacher Beliefs In Evolution Education, Tyler Bayes

Undergraduate Research and Engagement Symposium

The effectiveness of evolution education depends on limiting teacher discretion when it conflicts with scientific standards. Schools could mitigate creationist influences by promoting standardized, evidence-based science education while encouraging teachers to adopt neutral stances on non-scientific beliefs in their classrooms.


Ud Mathematicians Awarded $275k For ‘Pure’ Math Research, Student Mentoring, Dave Larsen Dec 2024

Ud Mathematicians Awarded $275k For ‘Pure’ Math Research, Student Mentoring, Dave Larsen

College of Arts and Sciences Newsroom

The projects explore abstract concepts and theoretical frameworks that could contribute to biology, physics and engineering applications.


The Physical And Psychological Impacts Of Exercise On Hypermobile Ehlers-Danlos Syndrome: A Case Study, Savannah Posey Dec 2024

The Physical And Psychological Impacts Of Exercise On Hypermobile Ehlers-Danlos Syndrome: A Case Study, Savannah Posey

Honors Projects

Hypermobile Ehlers-Danlos Syndrome (hEDS) is a subtype of a series of connective tissue disorders identified by joint hypermobility and multisystemic symptoms. It is caused by a lack of collagen production affecting the body’s ability to support important structures such as muscle, bone skin, and other connective tissues. To study the physical and psychological impacts of exercise on hypermobile Ehlers-Danlos Syndrome, a seven-week, phased exercise intervention program was implemented for a nineteen-year-old male with the disease. The program consisted of three phases focused on the strengthening of the surrounding musculature of the glenohumeral joint, along with improving muscular endurance and proprioception. …


Ada News - 12/09/2024, American Dental Association, Publishing Division Dec 2024

Ada News - 12/09/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.