Digital Commons Network^™

Ribosome Hibernation Factor Induces Antibiotic Persisters Of Mycobacterium Tuberculosis In Neutrophil-Rich Lung Lesions, Jamie Corro

Electronic Theses & Dissertations (2024 - present)

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is a prescient global health threat and the leading cause of death by an infectious agent. Treatment of Mtb infection involves administering 2-4 antibiotics for a minimum of 6 months. This extended drug regimen is required to target a subpopulation of persistent bacilli. As their name implies, these bacteria can “persist” by acquiring nonhereditary and transient antibiotic tolerance. Although the precise mechanism is unknown, it’s often attributed to slowing cellular growth and metabolic processes. During zinc deprivation, bacteria can remodel their ribosomes by replacing their zinc-binding paralogues containing the CXXC motif (C+) …

Optimizing The Community Health Worker (Chw) Program In Belize And Understanding Its Unique Intermediary Position Within The Health System: Perspective From The World Health Organization (Who) Health Systems Approach, Andrei R. Chell

Electronic Theses & Dissertations (2024 - present)

Human resources for health (HRH) are the backbone of a well-functioning and resilient health system. Issues related to HRH recruitment, retention, planning, leadership and governance have been amplified by the coronavirus disease 2019 (COVID-19) pandemic and have posed additional and unprecedented challenges in many countries. Community health workers (CHWs) in particular, are uniquely positioned to be frontline health care workers (HCWs) that are considered a vital link between communities and the formal health system. Globally, the benefits of CHW programs have been well documented, and there is substantial evidence of the efficacy and effectiveness of these programs. However, countries are …

Regulator Preferences And Underinvestment In Drinking Water Infrastructure, Chunyu Guo

Electronic Theses & Dissertations (2024 - present)

The infrastructure of U.S. drinking water systems faces chronic issues of low quality and underinvestment. As the water utilities in the U.S. are typically managed and regulated at the local municipal level, investment levels depend on the municipal regulator's preferences. Drawing from a dynamic framework, I specify and estimate the local regulators' objective function over drinking water infrastructure investment. This framework highlights the tradeoff between profit and consumer surplus and reveals how regulator preferences can deviate from net surplus optimization, resulting in underinvestment. My findings provide significant evidence that the drinking water infrastructure is underinvested. I reveal that the regulator's …

The Effect Of Presenting Concerns On Providers’ Assessment Of Patients' Suicide Risk, Alexandria Brunkow

Electronic Theses & Dissertations (2024 - present)

Objective: Suicide is the 10^th leading cause of death in the U.S. with nearly 50,000 people per year dying by suicide. Public health approaches to suicide prevention focus on screening people in primary and mental health care settings and offering treatment to those who screen positive. Research shows that mental health providers may not recognize risk factors for suicide and miss opportunities to screen patients who may be at risk. Providers’ mental representations of suicide risk may be influencing their perception of patient risk and contributing to low screening rates. This study used an experimental vignette case design to …

Remedying Educational Opportunity Program Freshmen's Knowledge Of Fractions And Views Of Mathematics Learning With Serious Video Games, Yan Tian

Electronic Theses & Dissertations (2024 - present)

Well-designed serious video games have great potential in mathematics education. This study aims to enrich our understanding of Slice Fractions and Slice Fractions 2 as remedy tools for college freshmen in an educational opportunities program. Specifically, drawing on resources-based epistemic cognition theory and scheme theory, the study investigated fourteen participants’ perspectives and experiences of playing these games, the impacts of the gameplay on their fraction schemes/operations and explicit conceptions of fractions, practices in fraction problem-solving, and views of mathematics learning. With a quasi-experimental design, each participant finished a pre-game interview and assessment, played SF1 or SF2, and completed a post-game …

Stable Oxygen Isotope Variability As A Proxy For Large-Scale Dynamics Of The South American Summer Monsoon, Rebecca Orrison

Electronic Theses & Dissertations (2024 - present)

Terrestrial archives of oxygen isotope records are particularly important for the study of South American hydrology, where hydroclimate observations over the historical period are sparse and often not long enough to characterize multidecadal to centennial-scale changes. Knowledge of such low-frequency changes is critically important for interpreting and constraining projections of future change and detecting the emergence of forced change beyond the envelope of natural variability. This dissertation focuses on the past, present, and future of South American tropical and subtropical climate, with an emphasis on the mature phase of the monsoon season (December, January, and February; DJF) using oxygen isotopes …

Understanding How Laypeople Perceive Sexual Harassment Claims From "Non-Typical" Claimants, Jennifer Mezzapelle

Electronic Theses & Dissertations (2024 - present)

Over the past four decades, scholars have generated a wealth of knowledge on the topic of sexual harassment. However, in much of this research, findings may have resulted from participants assuming that the target in question was a “typical” sexual harassment victim (i.e., a White, straight, cisgender woman who is traditionally feminine and conventionally attractive; Kaiser et al., 2022). As a result, the generalizability of this research is inherently limited, as it may not accurately reflect how sexual harassment is perceived when it is aimed at a person who does not possess the attributes typically associated with sexual harassment targets. …

A Foundation For Transformative Learning Practices In Higher Education, Michelle Meyer

Electronic Theses & Dissertations (2024 - present)

Higher education institutions in the United States have an ongoing rhetoric of claiming that they offer students educational experiences that build skills and prepare them for a career. However, reports from employers and students indicate that many schools are struggling to do so, and research imperative skills like critical thinking have wide construct definitions that can be difficult for institutions to work with. Transformative learning theory (TLT) is a theoretical practice and pedagogy that could support institutions by providing both a pedagogical foundation of what should occur in a classroom and a series of steps for what transformative learning looks …

Chemical Reduction Of Curved Molecular Nanographenes: Metal Intercalation And Core Transformation, Yikun Zhu

Electronic Theses & Dissertations (2024 - present)

The promising lithium storage capacity and fast charge transport rate make graphene a great candidate for energy storage applications. However, the harsh synthetic conditions lead to uneven size distribution and poor solubility, posing limitations on further applications and modifications of graphene and its derivatives. Molecular nanographenes, as graphene cutouts, possess outstanding chemical and physical properties stemming from their parent graphene but also demonstrate such unique features as controllable synthetic conditions, defined molecular structures, uniform size, and relatively good solubility. The improved solubility enables the use of solution chemistry methods for design modifications of molecular nanographenes and for systematical investigation of …

The Effect Of Learning Environment And Student Groupings On Math Skill Mastery, Erin Marr

Electronic Theses & Dissertations (2024 - present)

This study was designed to evaluate the impact of instructional group size and composition on student progress within a classwide math intervention. In terms of group size, groupings of greater than and less than 10 students were compared. In terms of group composition, homogeneous and heterogeneous groups were compared, defined by grouping the classes with standard deviations of student performance within the upper quartile (heterogeneous) and lower quartile (homogeneous) on a pre-intervention measure. The outcome measure used to evaluate student progress was the number of trials required for students to reach mastery on a specific skill within the 16-skill intervention …

Implications Of 5-Methylcytosine (M5c) And N4-Actylcytidine (Ac4c) In Epithelial To Mesenchymal Transition (Emt) In Human Breast Cancer, Manuel A. Pazos Ii

Electronic Theses & Dissertations (2024 - present)

Breast cancer is a complex disease that continues to haunt women and their loved ones around the world. It is currently the leading cause of cancer-related mortality among women. While most breast cancer patients can catch the disease before progression, others are less fortunate. The prognosis of those whose disease has advanced to metastatic or invasive breast cancer (IBC) is grim. Metastasis occurs when cancer cells undergo epithelial to mesenchymal transition (EMT), migrate to distant body tissues, then form new tumors. It is imperative to better understand the process of EMT to develop superior ways to detect breast cancer before …

Evaluating The Impact Of Instruction Mode And Experience On Meditation Intentions And Outcomes In Self-Taught Meditators And Mindfulness-Based Stress Reduction Completers, Leah Howard

Electronic Theses & Dissertations (2024 - present)

Objectives: The widespread availability of mindfulness-based practices has led to growing concern about the potential for misuse, namely the use of such practices as a control-based strategy rather than in an acceptance-based manner consistent with research. Thus, the present study aimed to elucidate factors (e.g., mode of instruction, meditation experience, psychological [in]flexibility [PF/PI]) that may relate to intentions guiding meditation use. Methods: Self-taught (ST) and Mindfulness-Based Stress Reduction (MBSR) meditators (N = 122, Mage = 46.54, SDage = 16.49, 65.6% Female) completed a battery of measures assessing meditation intentions (control- or acceptance-based), meditation experience (in months), PF/PI, psychological distress, …

Building Engaged Audiences: The Influence Of Multimedia-Inclusive Posts On Online Engagement Breadth And Depth For Arts And Culture Nonprofit Organizations, Sabrina Jeffcoat

Electronic Theses & Dissertations (2024 - present)

In recent years, broad access to digital communication tools provided by the “tech boom” has forced arts and culture nonprofit organizations (ACNPO) to transition to social media and mobile applications to engage audiences. While various approaches focus on building breadth (i.e. recirculation of content) and depth (i.e. replies) of engagement, ACNPO use multimedia to spur discussion and dissemination of their mission. Dependent on individual donors who generally give in small amounts, ACNPO are reliant on effective and visual social media campaigns to drive virality and broaden marketing appeal. Yet questions remain whether the presence of multimedia-inclusive posts (MIP) generates broader …

Advancements In Forensic Analysis: Development Of Mass Spectrometric And Chemometric Approaches For The Identification Of Synthetic New Psychoactive Substances And Plant Materials, Mónica Ventura

Electronic Theses & Dissertations (2024 - present)

While forensic science is a well-established discipline, a number of federal agencies have highlighted challenges that continue to plague the field and the extent to which these challenges remain unaddressed. Examples are the illegal trade of wildlife timber and the drug epidemic. Characterization of these materials requires nuanced method development for compound determination, matrix material-specific protocols, and heavy use of expensive consumables. The application of a technique such as direct analysis in real time – high-resolution mass spectrometry (DART-HRMS) provides the opportunity to circumvent many of the challenges presented by conventional methods. In general, little to no sample preparation is …

Molecular-Level Design Of Heterometallic Precursors For Rechargeable Battery Cathode Materials, Yuxuan Zhang

Electronic Theses & Dissertations (2024 - present)

The synthetic methods for rechargeable battery cathodes are rapidly evolving along with the continuous advancement of the materials themselves. Utilizing precursors for the synthesis of Li- and Na-ion cathode materials are known to ensure a phase-pure product with isotropic element distribution, thereby further enhancing the electrochemical properties of the cathode material. As more cathode materials with complex compositions continue to emerge, the strategies for designing the corresponding precursors are also getting diversified. One of the most promising directions is the employment of single-source precursors (SSPs), defined as molecules that contain all necessary elements in the proper ratio and decomposable under …

Assessment Of Spatial Distribution Patterns And Infestation Risk Over Time Of Spotted Lanterfly (Lycorma Delicatula) In New York State, Alanna Richman

Electronic Theses & Dissertations (2024 - present)

Spotted Lanternfly (Lycorma delicatula) is an invasive treehopper native to Asia. It was first introduced to Pennsylvania in 2014, and as of 2020 it has expanded to New York state. Their preferred host tree is the invasive tree of heaven (Ailanthus altissima), but they will feed on over 173 different plants worldwide. Preferred host species in New York state include agricultural vegetation such as grape vines and fruit trees. Positive Spotted Lanternfly site data collected by the New York Department of Agriculture and Markets and iMapInvasives were analyzed using ArcGIS Pro to assess spatial distribution patterns. …

A Descriptive Analysis Of Depressive Symptoms And Body Image By Race/Ethnicity And Nativity Status Among Adolescents, Radhika Prasad

Electronic Theses & Dissertations (2024 - present)

Previous research on the immigrant health paradox among children and adolescents show a mental health advantage yet it is unclear if this applies in a similar magnitude to females (Fillion et al., 2018; Zarei et al., 2023). Immigrants may be exposed to stressors related to immigration and acculturation. Some research suggests that females respond more to stress through internalizing symptoms relative to males (Hall-Lande et al., 2007; Adkins et al., 2009). Given these gender differences in stress response, female immigrants may be particularly vulnerable to the psychological consequences of immigration related stressors. The immigrant health paradox has also overlooked subjective …

"Not Trans Enough": A Qualitative Inquiry Of Non-Binary Individuals' Experiences Of Transphobia Within The Lgbtq+ Community, Alyssa Lombardi

Electronic Theses & Dissertations (2024 - present)

Transphobia has been well-documented to have detrimental impacts on the lives of transgender individuals. However, research typically has not focused on the experience of non-binary individuals, and particularly even less so on their experiences of within-group discrimination. This study used Interpretative Phenomenological Analysis to understand both the experience and expression of transphobia toward non-binary people from within the LGBTQ+ community. Twelve interviews were conducted with six non-binary individuals ranging in age from 23 to 33. Each interview was analyzed and coded, resulting in four superordinate themes: The Experience of Enbyphobia, The Impact of Enbyphobia, The Expression of Enbyphobia, and The …

The Exceptionalist-Normalist Continuum: Contents, Correlates, And Consequences Of Beliefs About The Psychological (A)Typicality Of Perpetrators Of Mass Atrocities, Dylan Campbell

Electronic Theses & Dissertations (2024 - present)

A consensus view within the literature on perpetrator behavior in mass atrocities holds that perpetrators tend to be psychologically typical rather than atypical and thus, that even “ordinary” people are capable of extreme acts of violence against civilians when the right combination of social-psychological forces is at work. Whereas much prior research speaks in some way to this claim’s validity, no prior study of which I am aware has directly investigated laypeople’s beliefs regarding the truth of this proposition. Here, I report findings from four preregistered studies (total N = 1,256) investigating the contents, correlates, and consequences of lay theories …

Advancing Small Molecule Therapies For Myotonic Dystrophy Type 1, Sawyer M. Hicks

Electronic Theses & Dissertations (2024 - present)

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by the expression of expanded CUG (CUG^exp) repeat RNA from the myotonic dystrophy protein kinase (DMPK) gene. This CUG^exp repeat RNA’s gain-of-function mechanism leads to the sequestration of muscleblind-like (MBNL) proteins, resulting in widespread alternative splicing dysregulation across tissues. Despite significant research, there are currently no approved therapeutics targeting the underlying causes of DM1. This dissertation explores the development and optimization of a novel class of small molecules, Modified Polycyclic Compounds (MPCs), designed to address splicing dysregulation in DM1. MPCs were designed from previously published …

Dishes Of Yesteryear: Memories, Stories, And Representations Of The Past Within Food Media, Diana Willis Bottomley

Electronic Theses & Dissertations (2024 - present)

In 1963, Julia Child revolutionized cooking television. Child’s The French Chef, which ran for ten years on the Boston public television station, WGBH, changed how American’s viewed, produced, and consumed food. And in the sixty years since Child’s debut, food media has grown in scope and popularity, increasingly altering how we communicate identity in and through food and foodways. In this dissertation, I examine the relation between food, media, and memory, with particular attention to: how the past moderates the connection between food and identity; how food media produce a sense of place integral to identity; and how food …

A Study Of Mercury Speciation Analysis Of Blood Using Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry For Human Biomonitoring And Clinical Applications, Emily Jean Pacer

Electronic Theses & Dissertations (2024 - present)

Mercury (Hg) exposure from environmental sources and consumer products presents a significant public health concern. The toxicity of methylmercury (MeHg) differs considerably from inorganic mercury (iHg), such that their separation and quantification in whole blood is helpful in identifying sources and possible pathways of exposure. Speciation methods provide a more detailed picture regarding human exposure to toxic mercury species and their effects on human health. This dissertation focuses on advanced analytical techniques for human biomonitoring and clinical diagnosis of Hg exposure. The primary aim of this research is to address important knowledge gaps and analytical challenges in studies of Hg …

Bias-Aware Gaze Uniformity Assessment In Group Images, Omkar Kulkarni

Electronic Theses & Dissertations (2024 - present)

Today, more than 5 billion photos are captured every day, with smartphones generating over 94\% of these images. However, despite advancements in technology, achieving aesthetically pleasing group photos remains challenging, especially when it comes to aligning the direction of everyone’s gaze. While current methods focus on facial features, they often fail to ensure consistent gaze direction. The introduction of the iPhone's Live mode, which captures a 1.5-second video snippet along with still images, complicates the selection of the best key photo due to its subjective nature and a lack of publicly available data, especially during the pandemic.

To address these …

Body Image Development And Eating Disorder Risk In Young Children: What Do Parents Want To Know?, Anna Atchison

Electronic Theses & Dissertations (2024 - present)

Background: Body image concerns and other risk factors for disordered eating can emerge in early childhood, but no interventions specifically target these early risk factors to mitigate future eating disorder risk. This study sought to quantify parents' knowledge of factors influencing eating disorder risk in young children, their concerns about their children’s eating behaviors, and perceived need and preferences for a parent education intervention addressing these topics. Methods: Parents (52 mothers, 55 fathers) of children aged 2-6 completed measures of parental eating disorder symptoms and internalized weight bias and child eating behaviors. Open-ended questions explored parents’ concerns about their children’s …

Public - Private In Vietnamese Universities: Exploring Sectoral Distinctiveness In Program Offerings, Lan Hoang

Electronic Theses & Dissertations (2024 - present)

The public-private issues in higher education have been a longstanding important topic of academic and policy interest, especially in the context of the public - private duality in most higher education systems. With PHE’s impressive growth over the past few decades, now enrolling one third of global HE enrollments, the study of PHE has also been expanded, with several national case studies and world/regional edited books yet being mostly ad hoc with minimal synthesis or comparative analysis (Levy, 2024). The current case study of Vietnam, employing Levy’s double distinctiveness approach in sectoral distinctiveness analysis with the intrasectoral dissection on the …

Outcome-Based Patient-Therapist Matching Implementation: A Study Of Clinician Beliefs And Attitudes, Ashleigh Smith

Electronic Theses & Dissertations (2024 - present)

Background. Implementation science aims to identify methods that support the adoption of evidence-based practices (EBPs), including measurement-based care (MBC) and MBC-informed patient-therapist matching. Examining clinician attitudes can elucidate potential barriers to implementing EBPs, and attitudinal differences may exist across groups of therapists. In the context of a patient-therapist matching implementation project, this multi-method study investigated the relationship between clinician characteristics, attitudes toward EBPs/MBC, and implementation climate. Method. A sample of N = 72 therapists completed measures of demographic and clinical characteristics, attitudes toward EBPs, perceptions of implementation climate, and attitudes toward monitoring and feedback. A subset of N …

Enhancing A Computer Model To Evaluate Rainwater Harvesting And Reuse Strategies For Landscape Irrigation Under Current And Future Climate Conditions, Siyu Li

Electronic Theses & Dissertations (2024 - present)

Urbanization and climate change have detrimental impacts on water quantity and quality. Rainwater harvesting/reuse for landscape irrigation with rain barrels/cisterns, which can assist urban hydrological/water quality restoration and provide a beneficial resource for irrigating landscape, holds significant potentials in urban areas under current and future climates. However, the impacts of rainwater harvesting/reuse strategies for landscape irrigation under a changing climate need to be comprehensively evaluated to assist decision-making. In addition, a comprehensive tool is needed to help stakeholders develop efficient strategies to harvest rainwater for landscape irrigation with rain barrels/cisterns.

To address the needs, the simulation of the sub-daily hydrological …

Everyone’S A Critic: Processes Of Legitimation In The Video Essay Genre On Youtube, Kendall Nagi

Electronic Theses & Dissertations (2024 - present)

The rise of video essays as a popular genre on YouTube is a notable development in the media criticism and intellectual work in online spaces. Theorization on criticism as intellectual work and the performance of expertise and credibility is well developed within sociology (Alexander 2004; Jacobs & Townsley 2017) but esearch on YouTube specifically is quite limited within the social sciences. Most existing research on the video essay genre comes from media studies and communications scholarship (McWhirter 2022; Smarandache 2021; Sylvia & Moody 2022). This study seeks to understand how creators working in the video essay genre, and more specifically, …

Investigating The Uncertainties Of Forecasting Ne Cold Season Precipitation In Numerical Weather Prediction Models, Yanna Chen

Electronic Theses & Dissertations (2024 - present)

A major winter storm on March 2, 2018, posed significant challenges in predicting precipitation type (P-type) in the northeast U.S., particularly the Hudson Valley. While National Weather Service (NWS) forecasts predicted a mix of rain and snow, observations showed predominantly snow, with errors in snow depth forecasts of 8-12 inches near Albany.

This study used the Weather Research and Forecasting (WRF) model to investigate how model physics (microphysics, cumulus, boundary layer, and radiation schemes) and domain configuration influenced snow depth predictions. Results revealed significant sensitivities to cumulus and radiation schemes, as well as the vertical resolution in the middle troposphere. …

Protecting Foreign Victims Of Trafficking In Iceland: An Interpretive Analysis Of Policy Efforts, Hlin Saethorsdottir

Electronic Theses & Dissertations (2024 - present)

Social justice and human rights are fundamental principles of social work. Today’s globalized world requires social workers to expand their local perspectives and to be alert to the negative sides of globalization, such as trafficking in person (TIP), which affects all countries around the world. TIP is a severe form of exploitation and a grave human rights violation (Jones et al., 2007). Iceland has been categorized as a transit and destination country for foreign victims who are mainly trafficked for sexual and labor exploitation (U.S. Department of State, 2016b).

Although much has been written on TIP, some scholars have pointed …