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2024

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The Lived Experiences Of Poverty Among Particularly Vulnerable Tribal Groups In A Rights-Based Anti-Poverty Programme In Jharkhand India, Monimala Sengupta Dec 2024

The Lived Experiences Of Poverty Among Particularly Vulnerable Tribal Groups In A Rights-Based Anti-Poverty Programme In Jharkhand India, Monimala Sengupta

Lingnan Theses (MPhil & PhD)

This research explores poverty and social exclusion among Primitive Tribal Groups (PVTGs) in India using T. H. Marshall's concept of social citizenship. With evidence showing a disproportionate burden of poverty in the Global South, indigenous groups are even overrepresented among the poor. India, home to one of the largest Indigenous populations, accounts for 70% of South Asia's impoverished, but the specific nature of poverty within these communities remain poorly understood.

Over the past two decades, India's national response to poverty has shifted towards rights-based, inclusive policies targeting marginalised communities such as Dalits, Scheduled Castes, and Scheduled Tribes, historically subjected to …


Climate Variability, Trends, And Impacts On The Yukon-Kuskokwim Delta With Insights Into Relationship-Building To Enhance Climate Science, Amy Sakura Hendricks Dec 2024

Climate Variability, Trends, And Impacts On The Yukon-Kuskokwim Delta With Insights Into Relationship-Building To Enhance Climate Science, Amy Sakura Hendricks

Atmospheric Sciences

Climate change impacts in the Arctic and Alaska vary widely, providing opportunities to study regional complexities. This thesis, guided by insights from Yup'ik Elders from the Yukon-Kuskokwim Delta, explores the significant impacts of climate change and examines four key topics: climate-vegetation connections, shifting hydroclimate regimes, the role of large-scale climate patterns in tundra wildfires, and fostering community relationships. The first paper investigates tundra vegetation productivity trends which have decreased in the Yukon-Kuskokwim Delta despite increasing temperatures during the growing season, contrasting with other Arctic tundra regions. Using available long-term climate datasets, a coherent multi-decadal pattern involving spring sea-ice concentration in …


Multimodal Assessment Battery And Heart Rate Variability Enhance Clinical Utility Of Buffalo Concussion Treadmill Test, Daniel Miner, Michael Shiraishi, Pamela Gibbons, Rahul Soangra, Brent Harper Dec 2024

Multimodal Assessment Battery And Heart Rate Variability Enhance Clinical Utility Of Buffalo Concussion Treadmill Test, Daniel Miner, Michael Shiraishi, Pamela Gibbons, Rahul Soangra, Brent Harper

Physical Therapy Faculty Articles and Research

Context: The Buffalo Concussion Treadmill Test (BCTT) for exercise intolerance following concussion may highlight underlying autonomic dysfunction. Autonomic function at rest and with exertion may be predictive of neurocognitive performance for individuals with sports-related concussion. The purpose of this study is to explore the feasibility and utility of combining multimodal assessments with heart rate variability (HRV) measures during the BCTT for individuals with a remote history of concussion. Design: Prospective cohort study design, pretest/posttest. Methods: Participants included 5 males and 5 females (N = 10, age: 25.2 [3.3] y old, height: 173.2 [11.2] cm, mass: 73.4 [13.7] …


Corynebacterium Minutissimum As A Rare Cause Of Tibial Osteomyelitis: A Case Report And Literature Review, Ayub Ansari, Dania Shoaib, Maher Asfour, Xiyue Wang, Pooja Sharma Dec 2024

Corynebacterium Minutissimum As A Rare Cause Of Tibial Osteomyelitis: A Case Report And Literature Review, Ayub Ansari, Dania Shoaib, Maher Asfour, Xiyue Wang, Pooja Sharma

Student Publications

Osteomyelitis is commonly caused by pathogens like Staphylococcus aureus, but rare organisms such as Corynebacterium minutissimum, typically associated with superficial skin infections, can also be implicated. Recognizing these atypical pathogens presents diagnostic and therapeutic challenges, especially in the presence of orthopedic hardware. We conducted a literature review yielding 25 studies and encompassing 797 patient cases, which highlights the emerging role of Corynebacterium species in osteomyelitis, particularly following trauma or surgical interventions. A 72-year-old man with a history of chronic right tibia and fibula fractures from a motor vehicle accident presented with progressively worsening leg pain over six months. …


Presence Of The Ade Multidrug Systems And Response To Triclosan Exposure In Acinetobacter Baumannii From Animal Origins, Sirawit Pagdepanichkit, Rungtip Chuanchuen Dec 2024

Presence Of The Ade Multidrug Systems And Response To Triclosan Exposure In Acinetobacter Baumannii From Animal Origins, Sirawit Pagdepanichkit, Rungtip Chuanchuen

The Thai Journal of Veterinary Medicine

Thirty Acinetobacter baumannii from animal origins were obtained from 210 animal carcasses submitted for post-mortem examination, including dogs (n=112), cats (n=45), rabbits (n=17), birds (n=15), pigs (n=7) and exotic animals (n=14). All the isolates were evaluated for antimicrobial susceptibility with absence and presence of efflux inhibitors i.e. reserpine and carbonyl cyanide m-chlorophenylhydrazone (CCCP) and expression profile of important six multidrug efflux systems (i.e. AdeABC, AdeDE, AdeFGH, AdeIJK, AbeM and AmvA). Fifteen isolates expressing different Ade multidrug efflux pumps were selected for determining transcription levels and regulatory mutations. A continuous in vitro exposure experiment with benzalkonium chloride, chlorhexidine and triclosan …


Exploring The Major Watershed Basins All Around The World: A Meta-Analysis For Basins Characteristics, Saad Mohammad Qurishi Dec 2024

Exploring The Major Watershed Basins All Around The World: A Meta-Analysis For Basins Characteristics, Saad Mohammad Qurishi

AUIQ Technical Engineering Science

Analysis of major watershed basins in a global vision provides a crucial information on sustainable management of water resource throughout the Earth. In this review, a globally significant watersheds were reviewed including the Murray-Darling Basin (Australia), Yangtze River basin (Asia), Volga River Basin (Europe), Nile River Basin (Africa), Hudson Bay Watershed & Mississippi Basin (Canada/North America), and the Amazon Basin (South America). A detailed overview was performed on emphasizing climate, agriculture, hydrology, groundwater, and ecological aspects of the watershed basins, providing holistic knowledge in terms of their environmental and socio-economic impacts. This review explores the challenges which are encountered by …


Development Of A Hybrid Intelligence Algorithm To Estimate The Derivative Weight Of Dawakin Tofa Clay For Heat Storage, Abubakar D. Maiwada, Abdullahi A. Adamu, Umar D. Maiwada, Sani I. Abba Dec 2024

Development Of A Hybrid Intelligence Algorithm To Estimate The Derivative Weight Of Dawakin Tofa Clay For Heat Storage, Abubakar D. Maiwada, Abdullahi A. Adamu, Umar D. Maiwada, Sani I. Abba

AUIQ Technical Engineering Science

The accurate prediction of thermogravimetric properties is critical for evaluating the suitability of natural materials like Dawakin Tofa clay for heat storage applications, but traditional linear models often fail to capture the complex, non-linear relationships inherent in such datasets. This study develops a hybrid intelligence framework integrating Bilateral Neural Network (BNN), Kernel Support Vector Machine (KSVM), Step-Wise Linear Regression (SWLR), and Robust Linear Regression (RLR) to predict the derivative weight of Dawakin Tofa clay based on 5,030 experimentally obtained instances. Comprehensive data preprocessing, including normalization, feature selection, and dataset splitting (80% training and 20% testing), ensured high-quality inputs for the …


Marine Microplastics Database, Andrew Allegra Dec 2024

Marine Microplastics Database, Andrew Allegra

Benefits of Ocean Observing Catalog (BOOC)

Global data about microplastics (less than 5 millimeters in length) have been provided by contributors from various research cruises and fieldwork around the globe for integration into this database. These data are difficult and expensive to obtain. All sources of data and information are needed in order to complete a comprehensive understanding of the challenges going forward.


“It’S Not Just Finding Them A Job”, (Re) Imagining Meaningful Employment And Economic Inclusion Among Forced Migrants: Narratives From Service Providers, Hanna Haran, Yesenia Alvarez Padilla, Jaclyn Kirsch, Arati Maleku Dec 2024

“It’S Not Just Finding Them A Job”, (Re) Imagining Meaningful Employment And Economic Inclusion Among Forced Migrants: Narratives From Service Providers, Hanna Haran, Yesenia Alvarez Padilla, Jaclyn Kirsch, Arati Maleku

Online Journal for Workforce Education and Development

Refugees and other forced migrants encounter numerous obstacles in securing employment that match their skills and qualifications. Building upon existing migration literature that explores integration into the United States labor market, this study investigates economic inclusion and the challenges and opportunities newcomers face in obtaining meaningful employment and utilizing their past education and work experience. We collected data through one-on-one interviews with service providers and community leaders (N = 11) engaged in refugee and forced migrant employment support, with over half (54.4%) identifying as migrants themselves. Data was analyzed using grounded theory techniques. The analysis yielded five overarching themes: (1) …


Comprehensive Guide For Cte Teachers: Implementing Functional Behavioral Assessments And Individualized Behavior Support Plans For Students With Intellectual And Developmental Disabilities, Hannah Martinez-Davenport, Debra Heban, Dawn Sandt Dec 2024

Comprehensive Guide For Cte Teachers: Implementing Functional Behavioral Assessments And Individualized Behavior Support Plans For Students With Intellectual And Developmental Disabilities, Hannah Martinez-Davenport, Debra Heban, Dawn Sandt

Online Journal for Workforce Education and Development

The training and requirements for initial licensure of Career and Technical Education (CTE) teachers exhibit considerable variation across states, potentially resulting in a limited familiarity with high-impact special education practices among CTE educators. Two critical practices within this domain are the conduct of Functional Behavior Assessments (FBAs) and the design of Individualized Behavior Support Plans (IBSPs). The FBA process entails a thorough, team-based approach to data collection and analysis aimed at identifying the underlying causes of behaviors that impede a student with a disability from achieving academic, social, emotional, and vocational objectives. Based on the insights derived from the FBA, …


Book Review: Decentering Whiteness In Libraries: A Framework For Inclusive Collection Management, Andrea Jamison, Shala K. Howell Dec 2024

Book Review: Decentering Whiteness In Libraries: A Framework For Inclusive Collection Management, Andrea Jamison, Shala K. Howell

School of Information Student Research Journal

No abstract provided.


Book Review : The Digital Environment: How We Live, Learn, Work, And Play Now By Pablo J. Boczkowski And Eugenia Mitchelstein, Devi Swamy Dec 2024

Book Review : The Digital Environment: How We Live, Learn, Work, And Play Now By Pablo J. Boczkowski And Eugenia Mitchelstein, Devi Swamy

School of Information Student Research Journal

The Digital Environment: How We Live, Learn, Work, and Play Now by Pablo J. Boczkowski and Eugenia Mitchelstein examines how digital technologies shape modern life, presenting the digital environment as a distinct sphere alongside natural and urban environments. Drawing on expert interviews, the authors explore its defining features—totality, duality, conflict, and indeterminacy—and their impact on society. The book highlights both the potential of digital tools to perpetuate inequities and their capacity to promote equity, offering insights particularly valuable to library and information science professionals.


Book Review: Creating Inclusive Libraries By Applying Universal Design: A Guide By Carli Spina, Katrina Williams Dec 2024

Book Review: Creating Inclusive Libraries By Applying Universal Design: A Guide By Carli Spina, Katrina Williams

School of Information Student Research Journal

Creating Inclusive Libraries by Applying Universal Design: A Guide is a practical and useful resource for improving libraries so that they are accessible to the broadest range of people possible. The format is well organized, and the case studies illustrate principles in engaging and recognizable ways. A reader who starts with no knowledge of Universal Design would acquire a working knowledge and be able to assess their own spaces with the guidance provided through examples and checklists. Rather than focus on resources for disabled patrons, Spina encourages readers to adopt a reflective practice for considering the needs of all library …


Academic Librarians With Invisible Disabilities Carry An Invisible Workload That Limits Their Career Potential, Katrina Heiderich Williams Dec 2024

Academic Librarians With Invisible Disabilities Carry An Invisible Workload That Limits Their Career Potential, Katrina Heiderich Williams

School of Information Student Research Journal

No abstract provided.


Redefining Reference Services In The 21st Century, Johanna Tunon Dec 2024

Redefining Reference Services In The 21st Century, Johanna Tunon

School of Information Student Research Journal

The role of reference services in libraries has evolved significantly in the 21st century, driven by technological advancements and changing user needs. This paper explores how reference services have transitioned from traditional, desk-centric interactions to encompass a wide array of platforms and tools, including digital innovations and generative AI. The decline in reference transactions has prompted librarians to adapt, shifting focus towards more complex consultations and instructional roles, while also navigating the blurred boundaries between reference assistance and formal instruction. The paper also examines the updated definitions and limitations of reference services by the Reference and User Services Association (RUSA), …


The Importance Of Graduate-Student-Led Academic Journals Within Library And Information Science, Odin Halvorson Dec 2024

The Importance Of Graduate-Student-Led Academic Journals Within Library And Information Science, Odin Halvorson

School of Information Student Research Journal

Graduate-student-led academic journals play a crucial role in fostering early career researchers' engagement with scholarly discourse within the field of Library and Information Science (LIS). This paper highlights the significance of these journals by examining their contributions to professional development, peer review practices, and inclusivity. Through a case study of the Student Research Journal (SRJ) at San Jose State University’s iSchool, I demonstrate how student-led journals provide invaluable experiential learning opportunities in leadership, organization, and research skills. The SRJ exemplifies these benefits by achieving international recognition with minimal resources, showcasing its impact-to-cost ratio. This paper also discusses the journal's role …


Ischool Student Research Journal, Vol.14, Iss.2 Dec 2024

Ischool Student Research Journal, Vol.14, Iss.2

School of Information Student Research Journal

Article citations within.


Book Review: The Sociology Of Cardi B: A Trap Feminist Approach, Dominique Dillard Dec 2024

Book Review: The Sociology Of Cardi B: A Trap Feminist Approach, Dominique Dillard

Journal of Critical Race and Ethnic Studies

No abstract provided.


Creating Spaces To Shift The Power Dynamics: Counter-Storytelling Through The Voices Of Empowerment Conference, Jordan González, Yolanda Sealey-Ruiz, Lonice Eversley, Aliya Holmes, Natalie Byfield Dec 2024

Creating Spaces To Shift The Power Dynamics: Counter-Storytelling Through The Voices Of Empowerment Conference, Jordan González, Yolanda Sealey-Ruiz, Lonice Eversley, Aliya Holmes, Natalie Byfield

Journal of Critical Race and Ethnic Studies

This qualitative study explores the transformative potential of counterstory as a method for promoting educational equity through the lens of racial literacy and the "Archeology of Self" framework. Rooted in critical race theory, counterstory enables marginalized voices to challenge and reshape dominant narratives within educational research and practice (Delgado & Stefancic, 1996; Delgado, Stefancic, & Harris, 2012; Ladson-Billings, 2013; Ladson-Billings, 2021; Martinez, 2020). The community-based study using a counter-storytelling approach draws on data from a focus group held during the 2024 Voices of Empowerment Conference, part of the Institute for Critical Race and Ethnic Studies (CRES) at St. John's University. …


Should We Clear The Cobwebs In Our Minds Or Dismantle Racial Structures? Reflections On The Lack Of Critical Thinking Of Higher Education Staff In The Uk, Chrissie Da Costa Dec 2024

Should We Clear The Cobwebs In Our Minds Or Dismantle Racial Structures? Reflections On The Lack Of Critical Thinking Of Higher Education Staff In The Uk, Chrissie Da Costa

Journal of Critical Race and Ethnic Studies

Higher education in the UK constantly emphasises  critical thinking for students. However, analysis of comments made about *Black students and staff indicate that some academic staff fail to critically analyse their thoughts, words, and deeds. This paper sets out to analyse these utterances of HE staff and to investigate whether they actively reproduce and are intended to reproduce racist practices in HE, which could affect the experience, performance, and confidence of some of these students and staff who identify as Black and Global Majorities.  Applying critical race theory and socio-ideological analysis of language (Bakhtin 1981 and Voloshinov 1973) to analyse …


Breaking News: The Presence Of The White Racial Frame In Partisan Cable News Networks’ Coverage Of Officers Killing Black Victims, Andrea C. Smith, Jonathan M. Cox Dec 2024

Breaking News: The Presence Of The White Racial Frame In Partisan Cable News Networks’ Coverage Of Officers Killing Black Victims, Andrea C. Smith, Jonathan M. Cox

Journal of Critical Race and Ethnic Studies

This study analyzes how two of the most popular and partisan cable news networks in the U.S., FOX and MSNBC, framed victims and officers in their coverage of cases where officers kill Black men. In addition, this work investigates how these networks discuss systemic racism. Using Feagin's white racial frame as a framework and critical discourse analysis as an analytical tool, the findings show that both networks exhibited anti-Black and pro-White framing within their reports. However, how these frames manifested differed across the networks, displaying differing similarities. Most notably, when counter-framing was present on MSNBC, they still perpetuated the anti-Black …


The Sound Of Change: Afrobeats And The Deconstruction Of African Stereotypes, Ibrahim Yusif Dec 2024

The Sound Of Change: Afrobeats And The Deconstruction Of African Stereotypes, Ibrahim Yusif

Journal of Critical Race and Ethnic Studies

This essay investigates how Afrobeats, a genre rooted in the dynamic cultural traditions of West Africa, serves as a strategic medium to counter the pervasive negative stereotypes about Africa perpetuated in Western media narratives. Often depicted through reductive portrayals of poverty, conflict, and disease, Africa’s representation in Western discourse starkly contrasts with the themes of vitality, resilience, and modernity inherent in Afrobeats music. I analyze the works of artists such as Rema, Davido, Burna Boy, and Tiwa Savage, highlighting how their music celebrates African pride, historical depth, and the empowerment of African women. Additionally, I examine the role of digital …


Intersectionality And The Framing Of News: A Discourse Analysis Of Black Press And Mainstream Coverage About Vice President Kamala Harris, Rockia K. Harris, Shaniece B. Bickham, Jinx C. Broussard Dec 2024

Intersectionality And The Framing Of News: A Discourse Analysis Of Black Press And Mainstream Coverage About Vice President Kamala Harris, Rockia K. Harris, Shaniece B. Bickham, Jinx C. Broussard

Journal of Critical Race and Ethnic Studies

Vice President Kamala Harris made history in 2020 by becoming the first woman, and first Black and Asian descent to earn this coveted role for any party (Clark & Adams, 2021). During her 2020 campaign, VP Harris showed how significant identity is to her autonomy as a first-generation American who openly supports historically black colleges and universities (HBCUs), as a Howard University alumna and sorority member under the National Pan-Hellenic Council (NPHC) (Zeleny et al., 2020). Thus, Harris' identity and storyline became a personified view of inclusivity, further emphasizing her culturally and historically significant election. As the 2024 U.S. presidential …


Closing The Literacy Gap: Correlation Of Chronic Illnesses On Reading Fluency, Nicolette Falvo Dec 2024

Closing The Literacy Gap: Correlation Of Chronic Illnesses On Reading Fluency, Nicolette Falvo

Education Theses

The purpose of this study is to investigate the impact of chronic physical health issues on literacy fluency among students spanning Pre-Kindergarten through eighth grade. Chronic illnesses, such as asthma, diabetes, and sickle cell disease, can significantly hinder academic performance, particularly in literacy. This research seeks to explore how specific literacy interventions can improve reading fluency for students managing health-related challenges. Utilizing a single-subject design, the study will examine individual cases to determine the effectiveness of tailored literacy strategies. The methodology includes both a baseline assessment phase and an intervention phase. Baseline assessments revealed that students with chronic health conditions …


Investigating The Expression Of C-Myc And Birc5 In Trail And Pbox-15 Treated Metastatic Prostate Cancer Cells, Corinne Kai Leng Chew, Hannah O'Toole, Daniela M. Zisterer, Seema M. Nathwani, Jade K. Pollock Dec 2024

Investigating The Expression Of C-Myc And Birc5 In Trail And Pbox-15 Treated Metastatic Prostate Cancer Cells, Corinne Kai Leng Chew, Hannah O'Toole, Daniela M. Zisterer, Seema M. Nathwani, Jade K. Pollock

SURE Journal: Science Undergraduate Research Experience Journal

Purpose Metastatic prostate cancer is associated with poor survival rate and limited treatment options. Overexpression of c-Myc and BIRC5 has been reported in prostate cancer cells which contribute to the development of the tumour environment. The specific tumour receptor mechanism of the death ligand TRAIL (tumour necrosis factor related apoptosis inducing ligand) has attracted remarkable therapeutic interest. However, many cancer cells are resistant to TRAIL monotherapy. A novel microtubule-targeting agent, PBOX-15 is known to exhibit anti-tumour activity in cancer cell lines including those with multi-drug resistance. Previous studies demonstrated that PBOX-15 is capable in sensitising cancer cells to TRAIL-mediated cell …


Comparing Multivalent Cross-Linked Sodium Alginate/ Montmorillonite Beads Containing Curcumin Or Cayenne Pepper As Drug Carriers And Their Antimicrobial Resistance, Shionainn Traynor, Shubham Sharma Dec 2024

Comparing Multivalent Cross-Linked Sodium Alginate/ Montmorillonite Beads Containing Curcumin Or Cayenne Pepper As Drug Carriers And Their Antimicrobial Resistance, Shionainn Traynor, Shubham Sharma

SURE Journal: Science Undergraduate Research Experience Journal

The aim of the following work was to investigate and compare curcumin and cayenne pepper in microbeads composed of sodium alginate (SA) crosslinked with montmorillonite (MMT) to act as drug carriers and their antimicrobial resistance. The microbeads were prepared through ion-exchange in multivalent solutions of CaCl2, MgCl2 and AlCl3. The microbeads were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX) and the time required for intercalation of curcumin and cayenne pepper with MMT. Simulated intestinal fluid (pH 7.3) and gastric fluid (pH 1.2) at 37°C were used for comparison in swelling studies. …


Association Between Body Mass Index, Abdominal Obesity And Menopause-Related Symptoms In Postmenopausal Women, Brianna A. Rice, Patricia Heavey Dec 2024

Association Between Body Mass Index, Abdominal Obesity And Menopause-Related Symptoms In Postmenopausal Women, Brianna A. Rice, Patricia Heavey

SURE Journal: Science Undergraduate Research Experience Journal

Abstract: Existing research demonstrates a lack of data on the relationship between body mass index (BMI) and menopause-related symptoms in postmenopausal women, particularly in Ireland. This study aimed to determine whether there is an association between BMI, general abdominal obesity and menopause-related symptoms in postmenopausal women. This should help bridge the data gap regarding postmenopausal women living in Ireland and their symptoms. Introduction: Menopause is defined as the permanent cessation of a woman's menstrual cycle. This is caused by a reduction of the secretion of oestrogen and progesterone, leading to reduced ovarian function. These changes have been attributed …


Reframing The Management Of Irritable Bowel Syndrome: Investigating The Efficacy Of A Modified Low Fodmap Diet Approach On Symptom Response, Tara Howley, Lorraine Cooney, Suzanne L. Doyle Dec 2024

Reframing The Management Of Irritable Bowel Syndrome: Investigating The Efficacy Of A Modified Low Fodmap Diet Approach On Symptom Response, Tara Howley, Lorraine Cooney, Suzanne L. Doyle

SURE Journal: Science Undergraduate Research Experience Journal

Background/ Objectives: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction with a multi-faceted pathogenesis. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), known as a low FODMAP diet (LFD), is an effective management option for many, however, it is complex, costly, and restrictive. A milder, modified low FODMAP diet (MLFD) is one suggested alternative, however, data on this approach is lacking. This study aimed to explore the efficacy of a MLFD versus a LFD on symptom improvement in IBS.

Subjects/ Methods: Routine clinical data collected on individuals with a Rome IV IBS diagnosis between August …


Tension Recordings From Primary Bronchi In Acta2-Gcamp8.1-Mvermilion Transgenic Mice, Qais Khalaf, Srijit Ghosh, Keith Thornbury Dec 2024

Tension Recordings From Primary Bronchi In Acta2-Gcamp8.1-Mvermilion Transgenic Mice, Qais Khalaf, Srijit Ghosh, Keith Thornbury

SURE Journal: Science Undergraduate Research Experience Journal

Contractions in smooth muscle cells are initiated by elevation of cytosolic Ca2+. It is of interest to measure Ca2+ signals in these cells. Transgenic Acta2-GCaMP8.1-mVermilion (GCaMP) mice express a genetically encoded intracellular fluorescent Ca2+ indicator in smooth muscle cells, have been developed to facilitate the study of Ca2+. However, there is a concern that the GCaMP Ca2+ indicator might buffer Ca2+ and interfere with the signals it is designed to measure. Therefore, the aim of this study was to compare tension responses in GCaMP and wild type (WT) mice to determine if …


Review: Cell Mechanisms In The Control Of Inflammatory Foundations Of Obesity And Secondary Metabolic Disorders, Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham Dec 2024

Review: Cell Mechanisms In The Control Of Inflammatory Foundations Of Obesity And Secondary Metabolic Disorders, Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Review: Obesity is a global threat to human health that is precipitating epidemically, with almost 2 billion adults categorised as overweight or obese in 2016. Ireland has one of the highest reports of obesity in Europe with 60% of Irish adults reported as overweight or obese. Inflammation plays an integral role in disease pathogenesis and is a major hallmark of obesity and obesity-related secondary co-morbidities. Obesity-related inflammation can precipitate several diseases, such breast cancer, insulin resistance, type II diabetes and cardiovascular issues. As obesity puts human health at inherent risk, the regulation of obesity-related inflammation is therefore a necessary component …