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Exploring The Potential Pathogenicity Of A Type 2 Diabetes Mellitus Associated Insr Missense Variant Of Uncertain Significance Through Daf-2 In The Caenorhabditis Elegans Model, Brittany White

Theses

Type 2 diabetes mellitus (T2DM) is hallmarked by insulin resistance, with the INSR gene identified as a key player in this condition in humans. This gene is known to harbor genetic variants with a wide range of clinical significance from pathogenic to variants of uncertain significance (VUS) to benign. This project investigates a VUS associated with T2DM identified through ClinVar. A gene mutational analysis, predictive amino acid substitution analysis, and protein modeling predict INSR c.1628C>T (p. Thr543Met) to be likely pathogenic or damaging. PolyPhen-2 predicts this variant to be probably damaging (HumDiv score of 1.000).

Evolutionary conservation of the …

Spring 2024, Office Of University Marketing And Communication

Bryant Magazine (1997-2019)(2024-present)

No abstract provided.

Prevalence Of Recess And Supportive Practices At A Nationwide Sample Of Public Elementary Schools In The United States, Marisa M. Tsai, Deborah A. Olarte, Erin R. Hager, Juliana F. W. Cohen, Lindsey Turner

University Author Recognition Bibliography: 2024

Background: Recess provides an important opportunity for children to be physically active during weekdays. Updated, nationally representative, prevalence estimates of elementary school recess practices in the United States are needed.

Methods: Surveys were sent to a nationally representative sample of 1010 public elementary schools in the 2019-2020 school year. Results were compared by region (Northeast, Midwest, South, West), urbanicity, size, racial and ethnic composition, and socioeconomic status (percent eligible for free/reduced-priced meals).

Results: A total of 559 responses were obtained. About 87.9% of schools provided at least 20 minutes of daily recess and 26.6% had trained recess supervisors. Most schools …

Gsl Researcher (Spring 2024)

GSL Researcher

GSL Researcher (Spring 2024)

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Publications and news

Food System Transformation: Farm To School, Dylan Upperman, Cameron Mahar

Undergraduate Scholarship

This project conducted with the Center for Resilient Communities at West Virginia University is focused on identifying and understanding barriers and opportunities present within the Farm to School program in West Virginia. Through this project, a producer survey was conducted to understand the production side of the program, a quantitative analysis was conducted of state and county level Farm to School purchasing data, and organizational sales through a local nonprofit were reviewed. Through this analysis, it was found that access to new markets and lack of knowledge and information posed a significant barrier for increased production from producers surveyed. It …

Nsu Kpcom Link - Spring 2024 - Volume 3.1, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

2024 Little International Agricultural Exposition Catalog, Little International Agricultural Exposition South Dakota State University

Little International "Little I" Agricultural Exposition Catalogs

This is the catalog for the 101st Little International 'Little I' Agricultural  Exposition, held on April 5th & 6th, 2024.

Is Asia On The Precipice Of A Currency Crisis? Exploring Regional Risks And Implications On The Global Economy, Hannah Deng

Independent Study Project (ISP) Collection

This paper examines the economic stability of Asia in the face of a potential currency crisis through drawing upon the historical context provided by the 1997 East Asian Financial Crisis. It systematically explores the characteristics and precursors of currency crises, analyzes the Asia-Pacific region’s response to past financial upheavals, and evaluates current macroeconomic vulnerabilities as well as policy frameworks. By juxtaposing the changes in Asia’s financial landscape from the late 20th century to the present, the study identifies persistent structural weaknesses and the region’s ongoing exposure to volatile global financial markets. It also considers the possibility of emerging markets establishing …

What Soil Is Worth: A Cost-Benefit Framework Analysis Of Syntropic Farming, Aubrey Kettley

Independent Study Project (ISP) Collection

Syntropic farming, a type of regenerative agriculture, models its farming system after a forest. This type of farming prioritizes soil health while also providing a varied yield of crops. Because it is a fairly new system globally, little research has been done on the economic impacts of syntropic farming, and therefore the feasibility of scaling up regenerative systems like this. This study aims to analyze the economic feasibility of this system through a literature review and a cost-benefit analysis framework. The results highlight the applicability, environmental advantage and economic feasibility of the system. Based on the presented framework, the short …

The Increase Of Allergies In Developed Countries: A Comparison Of The Quality Of Life And Psychosocial Burden Of Individuals With Food Allergies In Switzerland And The United States Of America, Adrienne Ell

Independent Study Project (ISP) Collection

The Hygiene Hypothesis suggests that as societies become increasingly sterile and there is less exposure to microorganisms early in life; consequently, there is an increase in inflammatory autoimmune disorders and allergies due to a maladapted immune system to the new sterile environment. This hypothesis can offer a possible explanation for the observed increase in allergies, specifically food allergies, in developed countries. To explore the psychosocial burden of allergies and evaluate the quality of life this paper will explore the food allergen labeling policies for prepackaged foods, the regulation of allergen information for non-prepackaged foods, and the psychosocial burden food allergies …

Nutri-Score, Warning Signs, And Facts Up Front – In Theory And In Practice A Comparative Analysis Of The Effectiveness Of Front-Of-Package Labeling Systems, Muskaan Makkar

Independent Study Project (ISP) Collection

Suboptimal diets contribute significantly to poor health and chronic diseases, with excessive sodium intake and low consumption of whole grains, fruits, and vegetables being major risk factors. To address this global nutrition burden, various countries have implemented front-of-package labeling (FOPL) systems such as the Nutri-Score, Warning Signs, and Facts Up Front.

This paper aims to analyze the effectiveness of these systems – which vary in development, design, content, and implementation – in both theory and practice. The methodology involves a comparative analysis of three FOPL systems, assessing their theoretical effectiveness with international guidelines and practical effectiveness through expert interviews and …

The Role Of Geomorphological Context In Vegetative Succession Within The Breiðamerkurjökull Glacial Foreland, Lucas Nerbonne

Independent Study Project (ISP) Collection

As glaciers retreat worldwide at an accelerating pace, understanding primary succession in these newly exposed landscapes becomes increasingly critical. This study examines the initial vegetative colonization patterns in glacial forelands, focusing on the influence of geomorphological formations of resulting plant communities. By analyzing vegetative communities in glaciofluvial and push moraine deposits, this study highlights how the more varied, channelized morphologies of fluvial deposits create potential microclimates better conducive to heterogenous plant colonization than the homogenous terrain of the nearby push moraine. Vegetative coverage, sediment size, and species abundance was collected at 480 sites across 6 different historical glacial extents across …

In And Through The Body: A Quantitative Exploration Of Embodiment In Eating Disorders, Lauren Zaniboni

PsyD Program in Clinical Psychology Doctoral Dissertations (New England)

The field of clinical psychology has long privileged cognitive and affective experience and information over that which is stored in, and communicated by, the body (Caldwell, 2018; Young, 2006). Despite the profound and complex web of interactions between mind and body in EDs, this subspecialty has been no exception. The need for improvements in eating disorder (ED) treatment outcomes is well documented and transtheoretically accepted. Current practice guidelines for the treatment of adult EDs recommend the utilization of cognitive, behavioral, and interpersonal strategies to target problematic thinking and deficits in emotion regulation that are thought to fuel ED behaviors (American …

Obesity: The Effects On Health And Healthcare, Nadia Abdulbaki

Posters - 2024

▪ In 2022, 1 in 8 people in the world were living with obesity.

▪ 2.8 million people die each year due to being overweight and obese.

▪ Obesity is a medical disease that raises the likelihood of developing various conditions and diseases that increase the chances of mortality for affected individuals.

▪ Obesity can be caused by several influences, whether behavioral, socioeconomic, environmental, hormonal, or genetic; however, the primary cause of obesity is mostly attributed to lifestyle. Specifically, it is the consumption of a high amount of calories in conjunction with a low amount of calories expended. This is …

A Deeper Dive Into Literature Published About Pinnipeds And Cetaceans Using The Five Domain Model, Aqsa Khan, Pedro Beltran

Posters - 2024

Research was conducted on cetaceans (whales and dolphins) (Figure 1) and pinnipeds (seals and sea lions) (Figure 2), focusing on five domains: nutrition, environment, health, behavior, and mental state. The goal was to identify the most discussed domain in existing literature. Specifically examining researchers' opinions on assessing the well-being of these marine mammals. After analyzing articles, hypotheses were formed suggesting that environmental factors are prominent for cetaceans, while behavior is the prominent domain for pinnipeds. To test these hypotheses, peer-reviewed articles were coded, providing both qualitative insights and quantitative representations of each domain's prevalence. The research uncovered the focal domains …

Improve Mentorship Through Meaningful Feedback And Coaching, Molly Montavon

Master's Theses & Capstone Projects

Mentoring within a school setting has been formalized and researched; however, there is minimal research surrounding mentoring in early childhood education settings. Students attending a community college for early childhood education are sent to centers that do not offer mentoring training to support the students through their education journey. This results in the students having inconsistent experiences that could lead to them exiting the program and field. The lack of formalized mentor training catalyzes this school improvement plan for a local community college. The mentors have experience and education while presenting best practices within early childhood education. This plan will …

Otterbein Towers Spring 2024, Otterbein University

Towers Magazine

A Healing Foundation; Teaching Excellence Spotlighted; FAQs for the Common Good; Outstanding Seniors; Serving Up a New Dining Experience for Students; Philanthropy; Alumni Matters, and Class Notes.

A Quality Improvement Project To Promote Awareness And Knowledge Of Nutrition As An Adjunctive Treatment Option For Chronic Insomnia, Sara J. Weelborg

Doctor of Nursing Practice Projects

Background

Insomnia is difficult to treat resulting in adverse outcomes. Traditional treatments are not always safe or accessible. Evidence, not readily available to providers, supports the adjunctive use of nutrition to ease symptoms.

Problem

Literature recommends the Mediterranean Diet for insomnia. A nutrition education module for psychiatric nurse practitioners (n=4) was created by a multidisciplinary committee to increase knowledge and comfort. Pre-post Likert-scale tool, multiple choice test, and interview questions were used to measure educational benefits.

Outcomes

All participants demonstrated knowledge acquisition (range 11% to 100%), increased intention to use information (range 9% to 43%), and positive feedback about nutrition …

Inadequate Choice In School Choice: An Analysis Of South Carolina's House Bill 3843 And The Implications For Public School Students And Rural Schools, J. Meadows Welch

South Carolina Law Review

No abstract provided.

Unlocking The Therapeutic Potential Of Ellagic Acid For Non-Alcoholic Fatty Liver Disease And Non-Alcoholic Steatohepatitis, Tharani Senavirathna, Armaghan Shafaei, Ricky Lareu, Lois Balmer

Research outputs 2022 to 2026

Obesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic steatohepatitis (NASH), which can progress to severe fibrosis, through to hepatocellular carcinoma. There currently exists no treatment for the long-term management of NAFLD/NASH, however, dietary interventions have been investigated for the treatment of NASH, including several polyphenolic compounds. Ellagic acid is one such polyphenolic compound. Nutraceutical food abundant in ellagic acid undergoes initial hydrolysis to free ellagic acid within the stomach and small intestine. …

April 2024 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Detection Of Some Virulence Factors Among Candida Albicans Isolated From Patients And Prevalence Of Candidalysin Gene Ece1, Safaa A. S. Al-Qaysi, Sokayna R. M. Al-Rubaie Al-Rubaie

Baghdad Science Journal

Candida albicans is a common cause of respiratory infection and oral candidiasis in people; it is an opportunistic yeast pathogen and a major cause of morbidity and mortality in the immunocompromised persons and causes superficial infections of mucosal surfaces which affect millions of people throughout world. The main goal of this study was investigating the prevalence of some virulence factors which has the ability to configure biofilm formation, proteinase, hemolysin production among C.albicans isolates that include prevalence of candidalysin gene Eec1. Samples were collected during the period May and August of 2022 from 280 samples (swabs) of different ages and …

Maternal Prebiotic Supplementation During Pregnancy And Lactation Modifies The Microbiome And Short Chain Fatty Acid Profile Of Both Mother And Infant, Jacquelyn M. Jones, Stacey N. Reinke, Mahsa Mousavi-Derazmahalleh, Johan Garssen, Maria C. Jenmalm, Ravisha Srinivasjois, Desiree Silva, Jeffrey Keelan, Susan L. Prescott, Debra J. Palmer, Claus T. Christophersen

Research outputs 2022 to 2026

Background & aims: Improving maternal gut health in pregnancy and lactation is a potential strategy to improve immune and metabolic health in offspring and curtail the rising rates of inflammatory diseases linked to alterations in gut microbiota. Here, we investigate the effects of a maternal prebiotic supplement (galacto-oligosaccharides and fructo-oligosaccharides), ingested daily from < 21 weeks' gestation to six months’ post-partum, in a double-blinded, randomised placebo-controlled trial. Methods: Stool samples were collected at multiple timepoints from 74 mother–infant pairs as part of a larger, double-blinded, randomised controlled allergy intervention trial. The participants were randomised to one of two groups; with one group receiving 14.2 g per day of prebiotic powder (galacto-oligosaccharides GOS and fructo-oligosaccharides FOS in ratio 9:1), and the other receiving a placebo powder consisting of 8.7 g per day of maltodextrin. The faecal microbiota of both mother and infants were assessed based on the analysis of bacterial 16S rRNA gene (V4 region) sequences, and short chain fatty acid (SCFA) concentrations in stool. Results: Significant differences in the maternal microbiota profiles between baseline and either 28-weeks’ or 36-weeks’ gestation were found in the prebiotic supplemented women. Infant microbial beta-diversity also significantly differed between prebiotic and placebo groups at 12-months of age. Supplementation was associated with increased abundance of commensal Bifidobacteria in the maternal microbiota, and a reduction in the abundance of Negativicutes in both maternal and infant microbiota. There were also changes in SCFA concentrations with maternal prebiotics supplementation, including significant differences in acetic acid concentration between intervention and control groups from 20 to 28-weeks’ gestation. Conclusion: Maternal prebiotic supplementation of 14.2 g per day GOS/FOS was found to favourably modify both the maternal and the developing infant gut microbiome. These results build on our understanding of the importance of maternal diet during pregnancy, and indicate that it is possible to intervene and modify the development of the infant microbiome by dietary modulation of the maternal gut microbiome.

The Role Of Pfkfb3 In Ampk-Activated Glut4 Translocation, Katherine Renee Bosch

Senior Honors Theses

Type 2 diabetes is a chronic, potentially deadly disease that impacts millions of Americans’ lives. Type 2 diabetes is characterized by increased blood glucose levels caused by insulin resistance. The normal insulin signaling pathway leads to glucose uptake by GLUT4 through activation of the IRS-1-PI3K-Akt pathway, as well as the insulin-independent pathway that utilizes AMPK. Additionally, PFKFB3 may play a role in insulin signaling and glucose uptake. PFKFB3 is an enzyme that plays an important role in activating PFK-1, which is a rate-limiting enzyme in glycolysis. PFKFB3 is frequently studied for its role in cancer due to its role in …

Nursing Care Regarding Social Determinants Of Health For Breastfeeding In Mothers And Infants, Natalie Jefson

Senior Honors Theses

Breastfeeding is incredibly important to the health and well-being of the mother-infant dyad. Because of this, there are both world-wide and national recommendations and guidelines for breastfeeding in the United States. Although many women choose to initiate breastfeeding, the percentage of women who continue breastfeeding for the recommended duration does not meet the Healthy People goal for the United States. Many factors influence this early breastfeeding cessation, including physical and socioeconomic barriers. Certain populations face increased barriers to reaching these goals related to social determinants of health which can and should be addressed by nurses through preventive measures and education.

Clinical Experiences Of Rn To Bscn Nursing Students In Kenyan Universities, Gladys Mbuthia, Gisela Rensburg Rensburg, Sheila Shaibu

School of Nursing & Midwifery, East Africa

Introduction and objective: Clinical learning environments play a great role in nursing training as they allow nursing students to develop their clinical skills by combining cognitive, psychomotor and affective skills. Consequently, clinical learning environments enable nursing students to bridge the theory-practice gap. Fewer studies have examined the clinical experiences of RN to BScN students in Kenya. This paper is part of analytical memo of a larger PhD study that sought to explore and describe the support needs of RN to BScN students in Kenyan universities. The paper focuses on clinical experiences of RN to BScN students.

Methods: Using a qualitative …

The Feasibility And Acceptability Of A Diabetes Survival Skills Intervention For Persons Transitioning From Prison To The Community, Louise Reagan, Rick A. Laguerre, Sarah Todd, Colleen Gallagher

Management Faculty Research and Publications

Community evidenced-based diabetes self-management education (DSME) models have not been examined for feasibility, acceptability, or effectiveness among persons transitioning from prison to the community to independent diabetes self-management (DSM). In a non-equivalent control group design with repeated measures, we examined the feasibility, acceptability, and preliminary effect of a 6-week, 1-h per week Diabetes Survival Skills (DSS) intervention on diabetes knowledge, distress, self-efficacy, and outcome expectancy for transitioning incarcerated males. Of the 92 participants (84% T2D, 83% using insulin, 40% Black, 20% White, 30% Latino, 66% high school or less, mean age 47.3 years, 84% length of incarceration ≤4 years ), …

Predicting Antibiotic Resistance In Recreational Areas, Daniela Azevedo

Honors Capstones

No abstract provided.

Identification Of Possible Regeneration Enhancer Sequences In Polypterus Senegalus By Atac Sequencing, Miles Casey-Flores

Honors Capstones

No abstract provided.

Bistro Mélange Business Plan, Cade Acosta

Honors Capstones

No abstract provided.